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PMC:548520 / 24978-28070 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
15676071-6715580-12933302 236-238 6715580 denotes 30
15676071-15161873-12933303 410-412 15161873 denotes 49
15676071-6055897-12933304 1061-1063 6055897 denotes 50
15676071-563768-12933305 1064-1066 563768 denotes 51
15676071-11733058-12933306 1841-1843 11733058 denotes 35
15676071-10329014-12933307 2532-2534 10329014 denotes 33

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5996 4-7 PR_EXT:000005904 denotes Crx
T5997 7-8 SO_EXT:sequence_nullness_or_absence denotes -
T5998 9-10 SO_EXT:sequence_nullness_or_absence denotes -
T5999 11-16 NCBITaxon:10088 denotes mouse
T6000 61-74 CL:0000210 denotes photoreceptor
T6001 75-83 GO:0045202 denotes synapses
T6002 106-116 PR_EXT:peripherin denotes peripherin
T6003 116-117 SO_EXT:sequence_nullness_or_absence denotes -
T6004 118-119 SO_EXT:sequence_nullness_or_absence denotes -
T6005 120-125 NCBITaxon:10088 denotes mouse
T6006 158-171 CL:0000210 denotes photoreceptor
T6007 172-181 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6008 211-225 CL:0000210 denotes photoreceptors
T6009 260-269 PR_EXT:000001245 denotes rhodopsin
T6010 271-274 PR_EXT:000001245 denotes Rho
T6011 280-297 CHEBI:23447 denotes cyclic nucleotide
T6012 280-320 PR_EXT:000000696 denotes cyclic nucleotide-gated channel, alpha-3
T6013 298-311 GO_EXT:0022836 denotes gated channel
T6014 322-327 PR_EXT:000000696 denotes CNGA3
T6015 345-349 NCBITaxon:10088 denotes mice
T6016 351-354 PR_EXT:000001245 denotes Rho
T6017 354-355 SO_EXT:sequence_nullness_or_absence denotes -
T6018 356-357 SO_EXT:sequence_nullness_or_absence denotes -
T6019 359-364 PR_EXT:000000696 denotes CNGA3
T6020 364-365 SO_EXT:sequence_nullness_or_absence denotes -
T6021 366-367 SO_EXT:sequence_nullness_or_absence denotes -
T6022 370-378 GO:0045202 denotes synapses
T6023 451-464 CL:0000210 denotes photoreceptor
T6024 465-479 GO:0007416 denotes synaptogenesis
T6025 508-521 GO:0001750 denotes outer segment
T6026 629-639 PR_EXT:peripherin denotes peripherin
T6027 639-640 SO_EXT:sequence_nullness_or_absence denotes -
T6028 641-642 SO_EXT:sequence_nullness_or_absence denotes -
T6029 643-647 NCBITaxon:10088 denotes mice
T6030 673-690 GO:0007602 denotes phototransduction
T6031 711-715 NCBITaxon:10088 denotes mice
T6032 749-762 CL:0000210 denotes photoreceptor
T6033 763-770 GO:0045202 denotes synapse
T6034 797-813 GO:0044456 denotes synapse elements
T6035 850-863 GO:0001750 denotes outer segment
T6036 928-941 CL:0000210 denotes photoreceptor
T6037 987-1004 GO:0007602 denotes phototransduction
T6038 1009-1016 GO:0045202 denotes synapse
T6039 1009-1026 GO:0007416 denotes synapse formation
T6040 1116-1119 PR_EXT:000005904 denotes Crx
T6041 1119-1120 SO_EXT:sequence_nullness_or_absence denotes -
T6042 1121-1122 SO_EXT:sequence_nullness_or_absence denotes -
T6043 1123-1137 CL:0000210 denotes photoreceptors
T6044 1157-1165 GO:0045202 denotes synaptic
T6045 1166-1173 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T6046 1198-1211 GO:0001750 denotes outer segment
T6047 1257-1260 PR_EXT:000005904 denotes Crx
T6048 1277-1290 CL:0000210 denotes photoreceptor
T6049 1291-1298 GO:0045202 denotes synapse
T6050 1291-1308 GO:0007416 denotes synapse formation
T6051 1321-1331 GO:0065007 denotes regulating
T6052 1367-1372 SO_EXT:0000704 denotes genes
T6053 1434-1444 GO:0010467 denotes expression
T6054 1455-1467 GO:0098793 denotes pre-synaptic
T6055 1468-1476 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6056 1477-1485 CHEBI_PR_EXT:protein denotes proteins
T6057 1497-1502 PR_EXT:000009311 denotes KIF3a
T6058 1504-1507 PR_EXT:000015849 denotes SV2
T6059 1513-1526 PR_EXT:000015890 denotes synaptophysin
T6060 1587-1590 PR_EXT:000005904 denotes Crx
T6061 1590-1591 SO_EXT:sequence_nullness_or_absence denotes -
T6062 1592-1593 SO_EXT:sequence_nullness_or_absence denotes -
T6063 1606-1612 UBERON:0000479 denotes tissue
T6064 1659-1662 CHEBI_SO_EXT:RNA denotes RNA
T6065 1721-1726 SO_EXT:0000704 denotes genes
T6066 1744-1748 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes tags
T6067 1775-1780 SO_EXT:0000704 denotes genes
T6068 1806-1809 CHEBI_SO_EXT:RNA denotes RNA
T6069 1867-1872 SO_EXT:0000704 denotes genes
T6070 1873-1882 GO:0010467 denotes expressed
T6071 1886-1900 CL:0000210 denotes photoreceptors
T6072 1937-1947 GO:0010467 denotes expression
T6073 1961-1964 PR_EXT:000005904 denotes Crx
T6074 1964-1965 SO_EXT:sequence_nullness_or_absence denotes -
T6075 1966-1967 SO_EXT:sequence_nullness_or_absence denotes -
T6076 1968-1973 NCBITaxon:10088 denotes mouse
T6077 2029-2042 CL:0000210 denotes photoreceptor
T6078 2029-2056 GO:0008594 denotes photoreceptor morphogenesis
T6079 2058-2062 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes Tags
T6080 2074-2079 SO_EXT:0000704 denotes genes
T6081 2085-2093 CHEBI_PR_EXT:protein denotes proteins
T6082 2094-2103 GO:0010467 denotes expressed
T6083 2107-2120 CL:0000210 denotes photoreceptor
T6084 2121-2130 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6085 2209-2248 PR_EXT:000008536 denotes HGF-regulated tyrosine kinase substrate
T6086 2213-2222 GO:0065007 denotes regulated
T6087 2223-2231 CHEBI_SO_EXT:tyrosine denotes tyrosine
T6088 2223-2238 GO_EXT:0004713 denotes tyrosine kinase
T6089 2254-2259 PR_EXT:000005877 denotes CRIPT
T6090 2260-2267 CHEBI_PR_EXT:protein denotes protein
T6091 2273-2288 PR_EXT:000015894 denotes synaptotagmin 1
T6092 2346-2350 SO_EXT:0000704 denotes gene
T6093 2377-2380 PR_EXT:000005904 denotes Crx
T6094 2380-2381 SO_EXT:sequence_nullness_or_absence denotes -
T6095 2382-2383 SO_EXT:sequence_nullness_or_absence denotes -
T6096 2384-2390 UBERON:0000966 denotes retina
T6097 2394-2398 PR_EXT:000017084 denotes HRG4
T6098 2402-2411 SO_EXT:0000853 denotes homologue
T6099 2419-2429 NCBITaxon:6239 denotes C. elegans
T6100 2430-2436 PR_EXT:Q10658 denotes Unc119
T6101 2437-2441 SO_EXT:0000704 denotes gene
T6102 2489-2496 SO_EXT:sequence_coding_function denotes encodes
T6103 2516-2530 GO:0097470 denotes ribbon synapse
T6104 2557-2568 GO_EXT:positive_regulation denotes upregulated
T6105 2586-2594 GO_EXT:reaction_or_response denotes response
T6106 2617-2625 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6107 2652-2657 SO_EXT:0000704 denotes genes
T6108 2658-2666 SO_EXT:sequence_coding_function denotes encoding
T6109 2676-2697 GO:0044430 denotes cytoskeletal elements
T6110 2724-2735 GO:0005874 denotes microtubule
T6111 2724-2756 PR_EXT:000010142 denotes microtubule associated protein 4
T6112 2747-2754 CHEBI_PR_EXT:protein denotes protein
T6113 2777-2786 PR_EXT:000005385 denotes cofilin 1
T6114 2795-2798 PR_EXT:000005904 denotes Crx
T6115 2798-2799 SO_EXT:sequence_nullness_or_absence denotes -
T6116 2800-2801 SO_EXT:sequence_nullness_or_absence denotes -
T6117 2802-2808 UBERON:0000966 denotes retina
T6118 2871-2876 SO_EXT:0000704 denotes genes
T6119 2905-2915 GO:0065007 denotes regulating
T6120 2916-2924 GO:0045202 denotes synaptic
T6121 2954-2959 SO_EXT:0000704 denotes genes
T6122 3077-3091 GO:0097470 denotes ribbon synapse

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5878 4-7 PR:000005904 denotes Crx
T5879 11-16 NCBITaxon:10088 denotes mouse
T5880 61-74 CL:0000210 denotes photoreceptor
T5881 75-83 GO:0045202 denotes synapses
T5882 120-125 NCBITaxon:10088 denotes mouse
T5883 158-171 CL:0000210 denotes photoreceptor
T5884 211-225 CL:0000210 denotes photoreceptors
T5885 260-269 PR:000001245 denotes rhodopsin
T5886 271-274 PR:000001245 denotes Rho
T5887 280-297 CHEBI:23447 denotes cyclic nucleotide
T5888 280-320 PR:000000696 denotes cyclic nucleotide-gated channel, alpha-3
T5889 322-327 PR:000000696 denotes CNGA3
T5890 345-349 NCBITaxon:10088 denotes mice
T5891 351-354 PR:000001245 denotes Rho
T5892 359-364 PR:000000696 denotes CNGA3
T5893 370-378 GO:0045202 denotes synapses
T5894 451-464 CL:0000210 denotes photoreceptor
T5895 465-479 GO:0007416 denotes synaptogenesis
T5896 508-521 GO:0001750 denotes outer segment
T5897 643-647 NCBITaxon:10088 denotes mice
T5898 673-690 GO:0007602 denotes phototransduction
T5899 711-715 NCBITaxon:10088 denotes mice
T5900 749-762 CL:0000210 denotes photoreceptor
T5901 763-770 GO:0045202 denotes synapse
T5902 797-813 GO:0044456 denotes synapse elements
T5903 850-863 GO:0001750 denotes outer segment
T5904 928-941 CL:0000210 denotes photoreceptor
T5905 987-1004 GO:0007602 denotes phototransduction
T5906 1009-1016 GO:0045202 denotes synapse
T5907 1009-1026 GO:0007416 denotes synapse formation
T5908 1116-1119 PR:000005904 denotes Crx
T5909 1123-1137 CL:0000210 denotes photoreceptors
T5910 1157-1165 GO:0045202 denotes synaptic
T5911 1198-1211 GO:0001750 denotes outer segment
T5912 1257-1260 PR:000005904 denotes Crx
T5913 1277-1290 CL:0000210 denotes photoreceptor
T5914 1291-1298 GO:0045202 denotes synapse
T5915 1291-1308 GO:0007416 denotes synapse formation
T5916 1321-1331 GO:0065007 denotes regulating
T5917 1367-1372 SO:0000704 denotes genes
T5918 1434-1444 GO:0010467 denotes expression
T5919 1455-1467 GO:0098793 denotes pre-synaptic
T5920 1497-1502 PR:000009311 denotes KIF3a
T5921 1504-1507 PR:000015849 denotes SV2
T5922 1513-1526 PR:000015890 denotes synaptophysin
T5923 1587-1590 PR:000005904 denotes Crx
T5924 1606-1612 UBERON:0000479 denotes tissue
T5925 1721-1726 SO:0000704 denotes genes
T5926 1775-1780 SO:0000704 denotes genes
T5927 1867-1872 SO:0000704 denotes genes
T5928 1873-1882 GO:0010467 denotes expressed
T5929 1886-1900 CL:0000210 denotes photoreceptors
T5930 1937-1947 GO:0010467 denotes expression
T5931 1961-1964 PR:000005904 denotes Crx
T5932 1968-1973 NCBITaxon:10088 denotes mouse
T5933 2029-2042 CL:0000210 denotes photoreceptor
T5934 2029-2056 GO:0008594 denotes photoreceptor morphogenesis
T5935 2074-2079 SO:0000704 denotes genes
T5936 2094-2103 GO:0010467 denotes expressed
T5937 2107-2120 CL:0000210 denotes photoreceptor
T5938 2209-2248 PR:000008536 denotes HGF-regulated tyrosine kinase substrate
T5939 2213-2222 GO:0065007 denotes regulated
T5940 2254-2259 PR:000005877 denotes CRIPT
T5941 2273-2288 PR:000015894 denotes synaptotagmin 1
T5942 2346-2350 SO:0000704 denotes gene
T5943 2377-2380 PR:000005904 denotes Crx
T5944 2384-2390 UBERON:0000966 denotes retina
T5945 2394-2398 PR:000017084 denotes HRG4
T5946 2402-2411 SO:0000853 denotes homologue
T5947 2419-2429 NCBITaxon:6239 denotes C. elegans
T5948 2430-2436 PR:Q10658 denotes Unc119
T5949 2437-2441 SO:0000704 denotes gene
T5950 2516-2530 GO:0097470 denotes ribbon synapse
T5951 2652-2657 SO:0000704 denotes genes
T5952 2676-2697 GO:0044430 denotes cytoskeletal elements
T5953 2724-2735 GO:0005874 denotes microtubule
T5954 2724-2756 PR:000010142 denotes microtubule associated protein 4
T5955 2777-2786 PR:000005385 denotes cofilin 1
T5956 2795-2798 PR:000005904 denotes Crx
T5957 2802-2808 UBERON:0000966 denotes retina
T5958 2871-2876 SO:0000704 denotes genes
T5959 2905-2915 GO:0065007 denotes regulating
T5960 2916-2924 GO:0045202 denotes synaptic
T5961 2954-2959 SO:0000704 denotes genes
T5962 3077-3091 GO:0097470 denotes ribbon synapse

craft-sa-dev

Id Subject Object Predicate Lexical cue
T6175 0-3 DT denotes The
T6176 11-16 NN denotes mouse
T6177 4-7 NN denotes Crx
T6178 7-8 SYM denotes -
T6179 8-9 HYPH denotes /
T6180 9-10 SYM denotes -
T6181 17-29 VBZ denotes demonstrates
T6182 30-33 DT denotes the
T6183 46-57 NN denotes abnormality
T6184 34-38 RBS denotes most
T6185 39-45 JJ denotes severe
T6186 58-60 IN denotes of
T6187 61-74 NN denotes photoreceptor
T6188 75-83 NNS denotes synapses
T6189 84-92 VBN denotes reported
T6190 93-95 IN denotes to
T6191 96-100 NN denotes date
T6192 100-101 . denotes .
T6193 101-240 sentence denotes The peripherin-/- mouse develops a normal complement of photoreceptor terminals which then degenerate as the photoreceptors are lost [30].
T6194 102-105 DT denotes The
T6195 120-125 NN denotes mouse
T6196 106-116 NN denotes peripherin
T6197 116-117 SYM denotes -
T6198 117-118 HYPH denotes /
T6199 118-119 SYM denotes -
T6200 126-134 VBZ denotes develops
T6201 135-136 DT denotes a
T6202 144-154 NN denotes complement
T6203 137-143 JJ denotes normal
T6204 155-157 IN denotes of
T6205 158-171 NN denotes photoreceptor
T6206 172-181 NNS denotes terminals
T6207 182-187 WDT denotes which
T6208 193-203 VBP denotes degenerate
T6209 188-192 RB denotes then
T6210 204-206 IN denotes as
T6211 230-234 VBN denotes lost
T6212 207-210 DT denotes the
T6213 211-225 NNS denotes photoreceptors
T6214 226-229 VBP denotes are
T6215 235-236 -LRB- denotes [
T6216 236-238 CD denotes 30
T6217 238-239 -RRB- denotes ]
T6218 239-240 . denotes .
T6219 240-414 sentence denotes Also, similarly in rhodopsin (Rho) and cyclic nucleotide-gated channel, alpha-3 (CNGA3) double knockout mice (Rho-/-, CNGA3-/-), synapses are reported to form normally [49].
T6220 241-245 RB denotes Also
T6221 383-391 VBN denotes reported
T6222 245-247 , denotes ,
T6223 247-256 RB denotes similarly
T6224 257-259 IN denotes in
T6225 260-269 NN denotes rhodopsin
T6226 270-271 -LRB- denotes (
T6227 271-274 NN denotes Rho
T6228 274-275 -RRB- denotes )
T6229 276-279 CC denotes and
T6230 280-286 JJ denotes cyclic
T6231 304-311 NN denotes channel
T6232 287-297 NN denotes nucleotide
T6233 298-303 VBN denotes gated
T6234 297-298 HYPH denotes -
T6235 313-318 NN denotes alpha
T6236 311-313 , denotes ,
T6237 345-349 NNS denotes mice
T6238 318-319 HYPH denotes -
T6239 319-320 CD denotes 3
T6240 321-322 -LRB- denotes (
T6241 322-327 NN denotes CNGA3
T6242 327-328 -RRB- denotes )
T6243 329-335 JJ denotes double
T6244 336-344 NN denotes knockout
T6245 350-351 -LRB- denotes (
T6246 351-354 NN denotes Rho
T6247 354-355 SYM denotes -
T6248 355-356 HYPH denotes /
T6249 356-357 SYM denotes -
T6250 357-359 , denotes ,
T6251 359-364 NN denotes CNGA3
T6252 364-365 SYM denotes -
T6253 365-366 HYPH denotes /
T6254 366-367 SYM denotes -
T6255 367-368 -RRB- denotes )
T6256 368-370 , denotes ,
T6257 370-378 NNS denotes synapses
T6258 379-382 VBP denotes are
T6259 392-394 TO denotes to
T6260 395-399 VB denotes form
T6261 400-408 RB denotes normally
T6262 409-410 -LRB- denotes [
T6263 410-412 CD denotes 49
T6264 412-413 -RRB- denotes ]
T6265 413-414 . denotes .
T6266 414-532 sentence denotes These observations demonstrate that photoreceptor synaptogenesis can occur in the absence of outer segment formation.
T6267 415-420 DT denotes These
T6268 421-433 NNS denotes observations
T6269 434-445 VBP denotes demonstrate
T6270 446-450 IN denotes that
T6271 484-489 VB denotes occur
T6272 451-464 NN denotes photoreceptor
T6273 465-479 NN denotes synaptogenesis
T6274 480-483 MD denotes can
T6275 490-492 IN denotes in
T6276 493-496 DT denotes the
T6277 497-504 NN denotes absence
T6278 505-507 IN denotes of
T6279 508-513 JJ denotes outer
T6280 514-521 NN denotes segment
T6281 522-531 NN denotes formation
T6282 531-532 . denotes .
T6283 532-771 sentence denotes In keeping with this observation is the fact that some electroretinogram activity is present in peripherin-/- mice, suggesting that minimal phototransduction is present in these mice, enough to drive activity at the photoreceptor synapse.
T6284 533-535 IN denotes In
T6285 566-568 VBZ denotes is
T6286 536-543 VBG denotes keeping
T6287 544-548 IN denotes with
T6288 549-553 DT denotes this
T6289 554-565 NN denotes observation
T6290 569-572 DT denotes the
T6291 573-577 NN denotes fact
T6292 578-582 IN denotes that
T6293 615-617 VBZ denotes is
T6294 583-587 DT denotes some
T6295 606-614 NN denotes activity
T6296 588-605 NN denotes electroretinogram
T6297 618-625 JJ denotes present
T6298 626-628 IN denotes in
T6299 629-639 NN denotes peripherin
T6300 643-647 NNS denotes mice
T6301 639-640 SYM denotes -
T6302 640-641 HYPH denotes /
T6303 641-642 SYM denotes -
T6304 647-649 , denotes ,
T6305 649-659 VBG denotes suggesting
T6306 660-664 IN denotes that
T6307 691-693 VBZ denotes is
T6308 665-672 JJ denotes minimal
T6309 673-690 NN denotes phototransduction
T6310 694-701 JJ denotes present
T6311 702-704 IN denotes in
T6312 705-710 DT denotes these
T6313 711-715 NNS denotes mice
T6314 715-717 , denotes ,
T6315 717-723 RB denotes enough
T6316 724-726 TO denotes to
T6317 727-732 VB denotes drive
T6318 733-741 NN denotes activity
T6319 742-744 IN denotes at
T6320 745-748 DT denotes the
T6321 763-770 NN denotes synapse
T6322 749-762 NN denotes photoreceptor
T6323 770-771 . denotes .
T6324 771-1068 sentence denotes In vitro studies wherein synapse elements are formed in the absence of proper outer segment development and, therefore, possible absence of light-dependent photoreceptor activity, have indicated the independence of phototransduction and synapse formation, at least for the initial stages [50,51].
T6325 772-774 FW denotes In
T6326 775-780 FW denotes vitro
T6327 781-788 NNS denotes studies
T6328 957-966 VBN denotes indicated
T6329 789-796 IN denotes wherein
T6330 818-824 VBN denotes formed
T6331 797-804 NN denotes synapse
T6332 805-813 NNS denotes elements
T6333 814-817 VBP denotes are
T6334 825-827 IN denotes in
T6335 828-831 DT denotes the
T6336 832-839 NN denotes absence
T6337 840-842 IN denotes of
T6338 843-849 JJ denotes proper
T6339 864-875 NN denotes development
T6340 850-855 JJ denotes outer
T6341 856-863 NN denotes segment
T6342 876-879 CC denotes and
T6343 879-881 , denotes ,
T6344 881-890 RB denotes therefore
T6345 901-908 NN denotes absence
T6346 890-892 , denotes ,
T6347 892-900 JJ denotes possible
T6348 909-911 IN denotes of
T6349 912-917 NN denotes light
T6350 918-927 JJ denotes dependent
T6351 917-918 HYPH denotes -
T6352 942-950 NN denotes activity
T6353 928-941 NN denotes photoreceptor
T6354 950-952 , denotes ,
T6355 952-956 VBP denotes have
T6356 967-970 DT denotes the
T6357 971-983 NN denotes independence
T6358 984-986 IN denotes of
T6359 987-1004 NN denotes phototransduction
T6360 1005-1008 CC denotes and
T6361 1009-1016 NN denotes synapse
T6362 1017-1026 NN denotes formation
T6363 1026-1028 , denotes ,
T6364 1028-1030 RB denotes at
T6365 1031-1036 RBS denotes least
T6366 1037-1040 IN denotes for
T6367 1041-1044 DT denotes the
T6368 1053-1059 NNS denotes stages
T6369 1045-1052 JJ denotes initial
T6370 1060-1061 -LRB- denotes [
T6371 1064-1066 CD denotes 51
T6372 1061-1063 CD denotes 50
T6373 1063-1064 , denotes ,
T6374 1066-1067 -RRB- denotes ]
T6375 1067-1068 . denotes .
T6376 1068-1222 sentence denotes These data then suggest that the fact that the Crx-/- photoreceptors do not have proper synaptic endings is not due to a lack of outer segment formation.
T6377 1069-1074 DT denotes These
T6378 1075-1079 NNS denotes data
T6379 1085-1092 VBP denotes suggest
T6380 1080-1084 RB denotes then
T6381 1093-1097 IN denotes that
T6382 1174-1176 VBZ denotes is
T6383 1098-1101 DT denotes the
T6384 1102-1106 NN denotes fact
T6385 1107-1111 IN denotes that
T6386 1145-1149 VB denotes have
T6387 1112-1115 DT denotes the
T6388 1123-1137 NNS denotes photoreceptors
T6389 1116-1119 NN denotes Crx
T6390 1119-1120 SYM denotes -
T6391 1120-1121 HYPH denotes /
T6392 1121-1122 SYM denotes -
T6393 1138-1140 VBP denotes do
T6394 1141-1144 RB denotes not
T6395 1150-1156 JJ denotes proper
T6396 1166-1173 NNS denotes endings
T6397 1157-1165 JJ denotes synaptic
T6398 1177-1180 RB denotes not
T6399 1181-1184 IN denotes due
T6400 1185-1187 IN denotes to
T6401 1188-1189 DT denotes a
T6402 1190-1194 NN denotes lack
T6403 1195-1197 IN denotes of
T6404 1198-1203 JJ denotes outer
T6405 1204-1211 NN denotes segment
T6406 1212-1221 NN denotes formation
T6407 1221-1222 . denotes .
T6408 1222-1389 sentence denotes A more likely explanation is that Crx plays a role in photoreceptor synapse formation, perhaps by regulating directly, or indirectly, important genes in this process.
T6409 1223-1224 DT denotes A
T6410 1237-1248 NN denotes explanation
T6411 1225-1229 RBR denotes more
T6412 1230-1236 JJ denotes likely
T6413 1249-1251 VBZ denotes is
T6414 1252-1256 IN denotes that
T6415 1261-1266 VBZ denotes plays
T6416 1257-1260 NN denotes Crx
T6417 1267-1268 DT denotes a
T6418 1269-1273 NN denotes role
T6419 1274-1276 IN denotes in
T6420 1277-1290 NN denotes photoreceptor
T6421 1291-1298 NN denotes synapse
T6422 1299-1308 NN denotes formation
T6423 1308-1310 , denotes ,
T6424 1310-1317 RB denotes perhaps
T6425 1318-1320 IN denotes by
T6426 1321-1331 VBG denotes regulating
T6427 1332-1340 RB denotes directly
T6428 1340-1342 , denotes ,
T6429 1342-1344 CC denotes or
T6430 1345-1355 RB denotes indirectly
T6431 1355-1357 , denotes ,
T6432 1357-1366 JJ denotes important
T6433 1367-1372 NNS denotes genes
T6434 1373-1375 IN denotes in
T6435 1376-1380 DT denotes this
T6436 1381-1388 NN denotes process
T6437 1388-1389 . denotes .
T6438 1389-1637 sentence denotes Using immunohistochemistry, we examined the expression of common pre-synaptic terminal proteins, including KIF3a, SV2, and synaptophysin, and were unable to observe qualitative differences between Crx-/- and control tissue at P14 (data not shown).
T6439 1390-1395 VBG denotes Using
T6440 1421-1429 VBD denotes examined
T6441 1396-1416 NN denotes immunohistochemistry
T6442 1416-1418 , denotes ,
T6443 1418-1420 PRP denotes we
T6444 1430-1433 DT denotes the
T6445 1434-1444 NN denotes expression
T6446 1445-1447 IN denotes of
T6447 1448-1454 JJ denotes common
T6448 1477-1485 NN denotes proteins
T6449 1455-1467 JJ denotes pre-synaptic
T6450 1468-1476 JJ denotes terminal
T6451 1485-1487 , denotes ,
T6452 1487-1496 VBG denotes including
T6453 1497-1502 NN denotes KIF3a
T6454 1502-1504 , denotes ,
T6455 1504-1507 NN denotes SV2
T6456 1507-1509 , denotes ,
T6457 1509-1512 CC denotes and
T6458 1513-1526 NN denotes synaptophysin
T6459 1526-1528 , denotes ,
T6460 1528-1531 CC denotes and
T6461 1532-1536 VBD denotes were
T6462 1537-1543 JJ denotes unable
T6463 1544-1546 TO denotes to
T6464 1547-1554 VB denotes observe
T6465 1555-1566 JJ denotes qualitative
T6466 1567-1578 NNS denotes differences
T6467 1579-1586 IN denotes between
T6468 1587-1590 NN denotes Crx
T6469 1606-1612 NN denotes tissue
T6470 1590-1591 SYM denotes -
T6471 1591-1592 HYPH denotes /
T6472 1592-1593 SYM denotes -
T6473 1594-1597 CC denotes and
T6474 1598-1605 NN denotes control
T6475 1613-1615 IN denotes at
T6476 1616-1619 NN denotes P14
T6477 1620-1621 -LRB- denotes (
T6478 1630-1635 VBN denotes shown
T6479 1621-1625 NNS denotes data
T6480 1626-1629 RB denotes not
T6481 1635-1636 -RRB- denotes )
T6482 1636-1637 . denotes .
T6483 1637-1845 sentence denotes Examination of their RNA levels by SAGE showed no significant difference for all 3 genes, though very few tags were recovered from these genes and thus the analysis of RNA levels may not be significant [35].
T6484 1638-1649 NN denotes Examination
T6485 1678-1684 VBD denotes showed
T6486 1650-1652 IN denotes of
T6487 1653-1658 PRP$ denotes their
T6488 1663-1669 NNS denotes levels
T6489 1659-1662 NN denotes RNA
T6490 1670-1672 IN denotes by
T6491 1673-1677 NN denotes SAGE
T6492 1685-1687 DT denotes no
T6493 1700-1710 NN denotes difference
T6494 1688-1699 JJ denotes significant
T6495 1711-1714 IN denotes for
T6496 1715-1718 DT denotes all
T6497 1721-1726 NNS denotes genes
T6498 1719-1720 CD denotes 3
T6499 1726-1728 , denotes ,
T6500 1728-1734 IN denotes though
T6501 1754-1763 VBN denotes recovered
T6502 1735-1739 RB denotes very
T6503 1740-1743 JJ denotes few
T6504 1744-1748 NNS denotes tags
T6505 1749-1753 VBD denotes were
T6506 1764-1768 IN denotes from
T6507 1769-1774 DT denotes these
T6508 1775-1780 NNS denotes genes
T6509 1781-1784 CC denotes and
T6510 1785-1789 RB denotes thus
T6511 1825-1827 VB denotes be
T6512 1790-1793 DT denotes the
T6513 1794-1802 NN denotes analysis
T6514 1803-1805 IN denotes of
T6515 1806-1809 NN denotes RNA
T6516 1810-1816 NNS denotes levels
T6517 1817-1820 MD denotes may
T6518 1821-1824 RB denotes not
T6519 1828-1839 JJ denotes significant
T6520 1840-1841 -LRB- denotes [
T6521 1841-1843 CD denotes 35
T6522 1843-1844 -RRB- denotes ]
T6523 1844-1845 . denotes .
T6524 1845-2057 sentence denotes However, since other genes expressed in photoreceptors were significantly altered in their expression level in the Crx-/- mouse, there are many candidates that could be important for photoreceptor morphogenesis.
T6525 1846-1853 RB denotes However
T6526 1981-1984 VBP denotes are
T6527 1853-1855 , denotes ,
T6528 1855-1860 IN denotes since
T6529 1920-1927 VBN denotes altered
T6530 1861-1866 JJ denotes other
T6531 1867-1872 NNS denotes genes
T6532 1873-1882 VBN denotes expressed
T6533 1883-1885 IN denotes in
T6534 1886-1900 NNS denotes photoreceptors
T6535 1901-1905 VBD denotes were
T6536 1906-1919 RB denotes significantly
T6537 1928-1930 IN denotes in
T6538 1931-1936 PRP$ denotes their
T6539 1948-1953 NN denotes level
T6540 1937-1947 NN denotes expression
T6541 1954-1956 IN denotes in
T6542 1957-1960 DT denotes the
T6543 1968-1973 NN denotes mouse
T6544 1961-1964 NN denotes Crx
T6545 1964-1965 SYM denotes -
T6546 1965-1966 HYPH denotes /
T6547 1966-1967 SYM denotes -
T6548 1973-1975 , denotes ,
T6549 1975-1980 EX denotes there
T6550 1985-1989 JJ denotes many
T6551 1990-2000 NNS denotes candidates
T6552 2001-2005 WDT denotes that
T6553 2012-2014 VB denotes be
T6554 2006-2011 MD denotes could
T6555 2015-2024 JJ denotes important
T6556 2025-2028 IN denotes for
T6557 2029-2042 NN denotes photoreceptor
T6558 2043-2056 NN denotes morphogenesis
T6559 2056-2057 . denotes .
T6560 2057-2329 sentence denotes Tags from three genes from proteins expressed in photoreceptor terminals were found to be decreased in a statistically significant fashion, namely the HGF-regulated tyrosine kinase substrate, the CRIPT protein, and synaptotagmin 1 (Blackshaw and Cepko, unpublished data).
T6561 2058-2062 NNS denotes Tags
T6562 2136-2141 VBN denotes found
T6563 2063-2067 IN denotes from
T6564 2068-2073 CD denotes three
T6565 2074-2079 NNS denotes genes
T6566 2080-2084 IN denotes from
T6567 2085-2093 NN denotes proteins
T6568 2094-2103 VBN denotes expressed
T6569 2104-2106 IN denotes in
T6570 2107-2120 NN denotes photoreceptor
T6571 2121-2130 NNS denotes terminals
T6572 2131-2135 VBD denotes were
T6573 2142-2144 TO denotes to
T6574 2148-2157 VBN denotes decreased
T6575 2145-2147 VB denotes be
T6576 2158-2160 IN denotes in
T6577 2161-2162 DT denotes a
T6578 2189-2196 NN denotes fashion
T6579 2163-2176 RB denotes statistically
T6580 2177-2188 JJ denotes significant
T6581 2196-2198 , denotes ,
T6582 2198-2204 RB denotes namely
T6583 2239-2248 NN denotes substrate
T6584 2205-2208 DT denotes the
T6585 2209-2212 NN denotes HGF
T6586 2213-2222 VBN denotes regulated
T6587 2212-2213 HYPH denotes -
T6588 2223-2231 NN denotes tyrosine
T6589 2232-2238 NN denotes kinase
T6590 2248-2250 , denotes ,
T6591 2250-2253 DT denotes the
T6592 2260-2267 NN denotes protein
T6593 2254-2259 NN denotes CRIPT
T6594 2267-2269 , denotes ,
T6595 2269-2272 CC denotes and
T6596 2273-2286 NN denotes synaptotagmin
T6597 2287-2288 CD denotes 1
T6598 2289-2290 -LRB- denotes (
T6599 2290-2299 NNP denotes Blackshaw
T6600 2300-2303 CC denotes and
T6601 2304-2309 NNP denotes Cepko
T6602 2309-2311 , denotes ,
T6603 2311-2322 JJ denotes unpublished
T6604 2323-2327 NNS denotes data
T6605 2327-2328 -RRB- denotes )
T6606 2328-2329 . denotes .
T6607 2329-2536 sentence denotes An example of a gene that was increased in the Crx-/- retina is HRG4 (a homologue of the C. elegans Unc119 gene) (Blackshaw and Cepko, unpublished data) which encodes a component of the ribbon synapse [33].
T6608 2330-2332 DT denotes An
T6609 2333-2340 NN denotes example
T6610 2391-2393 VBZ denotes is
T6611 2341-2343 IN denotes of
T6612 2344-2345 DT denotes a
T6613 2346-2350 NN denotes gene
T6614 2351-2355 WDT denotes that
T6615 2360-2369 VBN denotes increased
T6616 2356-2359 VBD denotes was
T6617 2370-2372 IN denotes in
T6618 2373-2376 DT denotes the
T6619 2384-2390 NN denotes retina
T6620 2377-2380 NN denotes Crx
T6621 2380-2381 SYM denotes -
T6622 2381-2382 HYPH denotes /
T6623 2382-2383 SYM denotes -
T6624 2394-2398 NN denotes HRG4
T6625 2399-2400 -LRB- denotes (
T6626 2400-2401 DT denotes a
T6627 2402-2411 NN denotes homologue
T6628 2412-2414 IN denotes of
T6629 2415-2418 DT denotes the
T6630 2437-2441 NN denotes gene
T6631 2419-2421 NNP denotes C.
T6632 2422-2429 NNP denotes elegans
T6633 2430-2436 NN denotes Unc119
T6634 2441-2442 -RRB- denotes )
T6635 2443-2444 -LRB- denotes (
T6636 2444-2453 NNP denotes Blackshaw
T6637 2454-2457 CC denotes and
T6638 2458-2463 NNP denotes Cepko
T6639 2463-2465 , denotes ,
T6640 2465-2476 JJ denotes unpublished
T6641 2477-2481 NNS denotes data
T6642 2481-2482 -RRB- denotes )
T6643 2483-2488 WDT denotes which
T6644 2489-2496 VBZ denotes encodes
T6645 2497-2498 DT denotes a
T6646 2499-2508 NN denotes component
T6647 2509-2511 IN denotes of
T6648 2512-2515 DT denotes the
T6649 2523-2530 NN denotes synapse
T6650 2516-2522 NN denotes ribbon
T6651 2531-2532 -LRB- denotes [
T6652 2532-2534 CD denotes 33
T6653 2534-2535 -RRB- denotes ]
T6654 2535-2536 . denotes .
T6655 2536-2637 sentence denotes The fact that it is upregulated might indicate a response to the lack of proper terminal structures.
T6656 2537-2540 DT denotes The
T6657 2541-2545 NN denotes fact
T6658 2575-2583 VB denotes indicate
T6659 2546-2550 IN denotes that
T6660 2557-2568 VBN denotes upregulated
T6661 2551-2553 PRP denotes it
T6662 2554-2556 VBZ denotes is
T6663 2569-2574 MD denotes might
T6664 2584-2585 DT denotes a
T6665 2586-2594 NN denotes response
T6666 2595-2597 IN denotes to
T6667 2598-2601 DT denotes the
T6668 2602-2606 NN denotes lack
T6669 2607-2609 IN denotes of
T6670 2610-2616 JJ denotes proper
T6671 2626-2636 NNS denotes structures
T6672 2617-2625 JJ denotes terminal
T6673 2636-2637 . denotes .
T6674 2637-2833 sentence denotes Several other genes encoding putative cytoskeletal elements also were increased (e.g. microtubule associated protein 4) or decreased (e.g. cofilin 1) in the Crx-/- retina, with P values of <.005.
T6675 2638-2645 JJ denotes Several
T6676 2652-2657 NNS denotes genes
T6677 2646-2651 JJ denotes other
T6678 2708-2717 VBN denotes increased
T6679 2658-2666 VBG denotes encoding
T6680 2667-2675 JJ denotes putative
T6681 2689-2697 NNS denotes elements
T6682 2676-2688 JJ denotes cytoskeletal
T6683 2698-2702 RB denotes also
T6684 2703-2707 VBD denotes were
T6685 2718-2719 -LRB- denotes (
T6686 2747-2754 NN denotes protein
T6687 2719-2723 FW denotes e.g.
T6688 2724-2735 NN denotes microtubule
T6689 2736-2746 VBN denotes associated
T6690 2755-2756 CD denotes 4
T6691 2756-2757 -RRB- denotes )
T6692 2758-2760 CC denotes or
T6693 2761-2770 VBN denotes decreased
T6694 2771-2772 -LRB- denotes (
T6695 2777-2784 NN denotes cofilin
T6696 2772-2776 FW denotes e.g.
T6697 2785-2786 CD denotes 1
T6698 2786-2787 -RRB- denotes )
T6699 2788-2790 IN denotes in
T6700 2791-2794 DT denotes the
T6701 2802-2808 NN denotes retina
T6702 2795-2798 NN denotes Crx
T6703 2798-2799 SYM denotes -
T6704 2799-2800 HYPH denotes /
T6705 2800-2801 SYM denotes -
T6706 2808-2810 , denotes ,
T6707 2810-2814 IN denotes with
T6708 2815-2816 NN denotes P
T6709 2817-2823 NNS denotes values
T6710 2824-2826 IN denotes of
T6711 2827-2828 SYM denotes <
T6712 2828-2832 CD denotes .005
T6713 2832-2833 . denotes .
T6714 2833-3092 sentence denotes It is not known whether any of these genes are involved in building or regulating synaptic structures, but they are now genes that might lead to a better understanding of the construction and function of the relatively unique structure of the ribbon synapse.
T6715 2834-2836 PRP denotes It
T6716 2844-2849 VBN denotes known
T6717 2837-2839 VBZ denotes is
T6718 2840-2843 RB denotes not
T6719 2850-2857 IN denotes whether
T6720 2881-2889 VBN denotes involved
T6721 2858-2861 DT denotes any
T6722 2862-2864 IN denotes of
T6723 2865-2870 DT denotes these
T6724 2871-2876 NNS denotes genes
T6725 2877-2880 VBP denotes are
T6726 2890-2892 IN denotes in
T6727 2893-2901 VBG denotes building
T6728 2902-2904 CC denotes or
T6729 2905-2915 VBG denotes regulating
T6730 2916-2924 JJ denotes synaptic
T6731 2925-2935 NNS denotes structures
T6732 2935-2937 , denotes ,
T6733 2937-2940 CC denotes but
T6734 2941-2945 PRP denotes they
T6735 2946-2949 VBP denotes are
T6736 2950-2953 RB denotes now
T6737 2954-2959 NNS denotes genes
T6738 2960-2964 WDT denotes that
T6739 2971-2975 VB denotes lead
T6740 2965-2970 MD denotes might
T6741 2976-2978 IN denotes to
T6742 2979-2980 DT denotes a
T6743 2988-3001 NN denotes understanding
T6744 2981-2987 JJR denotes better
T6745 3002-3004 IN denotes of
T6746 3005-3008 DT denotes the
T6747 3009-3021 NN denotes construction
T6748 3022-3025 CC denotes and
T6749 3026-3034 NN denotes function
T6750 3035-3037 IN denotes of
T6751 3038-3041 DT denotes the
T6752 3060-3069 NN denotes structure
T6753 3042-3052 RB denotes relatively
T6754 3053-3059 JJ denotes unique
T6755 3070-3072 IN denotes of
T6756 3073-3076 DT denotes the
T6757 3084-3091 NN denotes synapse
T6758 3077-3083 NN denotes ribbon
T6759 3091-3092 . denotes .
R3500 T6175 T6176 det The,mouse
R3501 T6176 T6181 nsubj mouse,demonstrates
R3502 T6177 T6176 nmod Crx,mouse
R3503 T6178 T6177 punct -,Crx
R3504 T6179 T6177 punct /,Crx
R3505 T6180 T6177 punct -,Crx
R3506 T6182 T6183 det the,abnormality
R3507 T6183 T6181 dobj abnormality,demonstrates
R3508 T6184 T6185 advmod most,severe
R3509 T6185 T6183 amod severe,abnormality
R3510 T6186 T6183 prep of,abnormality
R3511 T6187 T6188 compound photoreceptor,synapses
R3512 T6188 T6186 pobj synapses,of
R3513 T6189 T6183 acl reported,abnormality
R3514 T6190 T6189 prep to,reported
R3515 T6191 T6190 pobj date,to
R3516 T6192 T6181 punct .,demonstrates
R3517 T6194 T6195 det The,mouse
R3518 T6195 T6200 nsubj mouse,develops
R3519 T6196 T6195 nmod peripherin,mouse
R3520 T6197 T6196 punct -,peripherin
R3521 T6198 T6196 punct /,peripherin
R3522 T6199 T6196 punct -,peripherin
R3523 T6201 T6202 det a,complement
R3524 T6202 T6200 dobj complement,develops
R3525 T6203 T6202 amod normal,complement
R3526 T6204 T6202 prep of,complement
R3527 T6205 T6206 compound photoreceptor,terminals
R3528 T6206 T6204 pobj terminals,of
R3529 T6207 T6208 dep which,degenerate
R3530 T6208 T6202 relcl degenerate,complement
R3531 T6209 T6208 advmod then,degenerate
R3532 T6210 T6211 mark as,lost
R3533 T6211 T6208 advcl lost,degenerate
R3534 T6212 T6213 det the,photoreceptors
R3535 T6213 T6211 nsubjpass photoreceptors,lost
R3536 T6214 T6211 auxpass are,lost
R3537 T6215 T6216 punct [,30
R3538 T6216 T6200 parataxis 30,develops
R3539 T6217 T6216 punct ],30
R3540 T6218 T6200 punct .,develops
R3541 T6220 T6221 advmod Also,reported
R3542 T6222 T6221 punct ", ",reported
R3543 T6223 T6221 advmod similarly,reported
R3544 T6224 T6221 prep in,reported
R3545 T6225 T6224 pobj rhodopsin,in
R3546 T6226 T6225 punct (,rhodopsin
R3547 T6227 T6225 appos Rho,rhodopsin
R3548 T6228 T6225 punct ),rhodopsin
R3549 T6229 T6225 cc and,rhodopsin
R3550 T6230 T6231 amod cyclic,channel
R3551 T6231 T6235 nmod channel,alpha
R3552 T6232 T6233 npadvmod nucleotide,gated
R3553 T6233 T6231 amod gated,channel
R3554 T6234 T6233 punct -,gated
R3555 T6235 T6237 nmod alpha,mice
R3556 T6236 T6235 punct ", ",alpha
R3557 T6237 T6225 conj mice,rhodopsin
R3558 T6238 T6235 punct -,alpha
R3559 T6239 T6235 nummod 3,alpha
R3560 T6240 T6235 punct (,alpha
R3561 T6241 T6235 appos CNGA3,alpha
R3562 T6242 T6237 punct ),mice
R3563 T6243 T6244 amod double,knockout
R3564 T6244 T6237 compound knockout,mice
R3565 T6245 T6237 punct (,mice
R3566 T6246 T6237 appos Rho,mice
R3567 T6247 T6246 punct -,Rho
R3568 T6248 T6246 punct /,Rho
R3569 T6249 T6246 punct -,Rho
R3570 T6250 T6246 punct ", ",Rho
R3571 T6251 T6246 appos CNGA3,Rho
R3572 T6252 T6251 punct -,CNGA3
R3573 T6253 T6251 punct /,CNGA3
R3574 T6254 T6251 punct -,CNGA3
R3575 T6255 T6221 punct ),reported
R3576 T6256 T6221 punct ", ",reported
R3577 T6257 T6221 nsubjpass synapses,reported
R3578 T6258 T6221 auxpass are,reported
R3579 T6259 T6260 aux to,form
R3580 T6260 T6221 xcomp form,reported
R3581 T6261 T6260 advmod normally,form
R3582 T6262 T6263 punct [,49
R3583 T6263 T6221 parataxis 49,reported
R3584 T6264 T6263 punct ],49
R3585 T6265 T6221 punct .,reported
R3586 T6267 T6268 det These,observations
R3587 T6268 T6269 nsubj observations,demonstrate
R3588 T6270 T6271 mark that,occur
R3589 T6271 T6269 ccomp occur,demonstrate
R3590 T6272 T6273 compound photoreceptor,synaptogenesis
R3591 T6273 T6271 nsubj synaptogenesis,occur
R3592 T6274 T6271 aux can,occur
R3593 T6275 T6271 prep in,occur
R3594 T6276 T6277 det the,absence
R3595 T6277 T6275 pobj absence,in
R3596 T6278 T6277 prep of,absence
R3597 T6279 T6280 amod outer,segment
R3598 T6280 T6281 compound segment,formation
R3599 T6281 T6278 pobj formation,of
R3600 T6282 T6269 punct .,demonstrate
R3601 T6284 T6285 prep In,is
R3602 T6286 T6284 pcomp keeping,In
R3603 T6287 T6286 prep with,keeping
R3604 T6288 T6289 det this,observation
R3605 T6289 T6287 pobj observation,with
R3606 T6290 T6291 det the,fact
R3607 T6291 T6285 nsubj fact,is
R3608 T6292 T6293 mark that,is
R3609 T6293 T6291 acl is,fact
R3610 T6294 T6295 det some,activity
R3611 T6295 T6293 nsubj activity,is
R3612 T6296 T6295 compound electroretinogram,activity
R3613 T6297 T6293 acomp present,is
R3614 T6298 T6293 prep in,is
R3615 T6299 T6300 nmod peripherin,mice
R3616 T6300 T6298 pobj mice,in
R3617 T6301 T6299 punct -,peripherin
R3618 T6302 T6299 punct /,peripherin
R3619 T6303 T6299 punct -,peripherin
R3620 T6304 T6293 punct ", ",is
R3621 T6305 T6293 advcl suggesting,is
R3622 T6306 T6307 mark that,is
R3623 T6307 T6305 ccomp is,suggesting
R3624 T6308 T6309 amod minimal,phototransduction
R3625 T6309 T6307 nsubj phototransduction,is
R3626 T6310 T6307 acomp present,is
R3627 T6311 T6307 prep in,is
R3628 T6312 T6313 det these,mice
R3629 T6313 T6311 pobj mice,in
R3630 T6314 T6307 punct ", ",is
R3631 T6315 T6307 advmod enough,is
R3632 T6316 T6317 aux to,drive
R3633 T6317 T6315 xcomp drive,enough
R3634 T6318 T6317 dobj activity,drive
R3635 T6319 T6317 prep at,drive
R3636 T6320 T6321 det the,synapse
R3637 T6321 T6319 pobj synapse,at
R3638 T6322 T6321 compound photoreceptor,synapse
R3639 T6323 T6285 punct .,is
R3640 T6325 T6326 advmod In,vitro
R3641 T6326 T6327 amod vitro,studies
R3642 T6327 T6328 nsubj studies,indicated
R3643 T6329 T6330 prep wherein,formed
R3644 T6330 T6327 relcl formed,studies
R3645 T6331 T6332 compound synapse,elements
R3646 T6332 T6330 nsubjpass elements,formed
R3647 T6333 T6330 auxpass are,formed
R3648 T6334 T6330 prep in,formed
R3649 T6335 T6336 det the,absence
R3650 T6336 T6334 pobj absence,in
R3651 T6337 T6336 prep of,absence
R3652 T6338 T6339 amod proper,development
R3653 T6339 T6337 pobj development,of
R3654 T6340 T6341 amod outer,segment
R3655 T6341 T6339 compound segment,development
R3656 T6342 T6336 cc and,absence
R3657 T6343 T6336 punct ", ",absence
R3658 T6344 T6345 advmod therefore,absence
R3659 T6345 T6336 conj absence,absence
R3660 T6346 T6345 punct ", ",absence
R3661 T6347 T6345 amod possible,absence
R3662 T6348 T6345 prep of,absence
R3663 T6349 T6350 npadvmod light,dependent
R3664 T6350 T6352 amod dependent,activity
R3665 T6351 T6350 punct -,dependent
R3666 T6352 T6348 pobj activity,of
R3667 T6353 T6352 compound photoreceptor,activity
R3668 T6354 T6328 punct ", ",indicated
R3669 T6355 T6328 aux have,indicated
R3670 T6356 T6357 det the,independence
R3671 T6357 T6328 dobj independence,indicated
R3672 T6358 T6357 prep of,independence
R3673 T6359 T6358 pobj phototransduction,of
R3674 T6360 T6359 cc and,phototransduction
R3675 T6361 T6362 compound synapse,formation
R3676 T6362 T6359 conj formation,phototransduction
R3677 T6363 T6328 punct ", ",indicated
R3678 T6364 T6365 advmod at,least
R3679 T6365 T6366 advmod least,for
R3680 T6366 T6328 prep for,indicated
R3681 T6367 T6368 det the,stages
R3682 T6368 T6366 pobj stages,for
R3683 T6369 T6368 amod initial,stages
R3684 T6370 T6371 punct [,51
R3685 T6371 T6328 parataxis 51,indicated
R3686 T6372 T6371 nummod 50,51
R3687 T6373 T6371 punct ",",51
R3688 T6374 T6371 punct ],51
R3689 T6375 T6328 punct .,indicated
R3690 T6377 T6378 det These,data
R3691 T6378 T6379 nsubj data,suggest
R3692 T6380 T6379 advmod then,suggest
R3693 T6381 T6382 mark that,is
R3694 T6382 T6379 ccomp is,suggest
R3695 T6383 T6384 det the,fact
R3696 T6384 T6382 nsubj fact,is
R3697 T6385 T6386 mark that,have
R3698 T6386 T6384 acl have,fact
R3699 T6387 T6388 det the,photoreceptors
R3700 T6388 T6386 nsubj photoreceptors,have
R3701 T6389 T6388 nmod Crx,photoreceptors
R3702 T6390 T6389 punct -,Crx
R3703 T6391 T6389 punct /,Crx
R3704 T6392 T6389 punct -,Crx
R3705 T6393 T6386 aux do,have
R3706 T6394 T6386 neg not,have
R3707 T6395 T6396 amod proper,endings
R3708 T6396 T6386 dobj endings,have
R3709 T6397 T6396 amod synaptic,endings
R3710 T6398 T6382 neg not,is
R3711 T6399 T6382 prep due,is
R3712 T6400 T6399 pcomp to,due
R3713 T6401 T6402 det a,lack
R3714 T6402 T6399 pobj lack,due
R3715 T6403 T6402 prep of,lack
R3716 T6404 T6405 amod outer,segment
R3717 T6405 T6406 compound segment,formation
R3718 T6406 T6403 pobj formation,of
R3719 T6407 T6379 punct .,suggest
R3720 T6409 T6410 det A,explanation
R3721 T6410 T6413 nsubj explanation,is
R3722 T6411 T6412 advmod more,likely
R3723 T6412 T6410 amod likely,explanation
R3724 T6414 T6415 mark that,plays
R3725 T6415 T6413 ccomp plays,is
R3726 T6416 T6415 nsubj Crx,plays
R3727 T6417 T6418 det a,role
R3728 T6418 T6415 dobj role,plays
R3729 T6419 T6415 prep in,plays
R3730 T6420 T6421 compound photoreceptor,synapse
R3731 T6421 T6422 compound synapse,formation
R3732 T6422 T6419 pobj formation,in
R3733 T6423 T6415 punct ", ",plays
R3734 T6424 T6425 advmod perhaps,by
R3735 T6425 T6415 prep by,plays
R3736 T6426 T6425 pcomp regulating,by
R3737 T6427 T6426 advmod directly,regulating
R3738 T6428 T6427 punct ", ",directly
R3739 T6429 T6427 cc or,directly
R3740 T6430 T6427 conj indirectly,directly
R3741 T6431 T6426 punct ", ",regulating
R3742 T6432 T6433 amod important,genes
R3743 T6433 T6426 dobj genes,regulating
R3744 T6434 T6433 prep in,genes
R3745 T6435 T6436 det this,process
R3746 T6436 T6434 pobj process,in
R3747 T6437 T6413 punct .,is
R3748 T6439 T6440 advcl Using,examined
R3749 T6441 T6439 dobj immunohistochemistry,Using
R3750 T6442 T6440 punct ", ",examined
R3751 T6443 T6440 nsubj we,examined
R3752 T6444 T6445 det the,expression
R3753 T6445 T6440 dobj expression,examined
R3754 T6446 T6440 prep of,examined
R3755 T6447 T6448 amod common,proteins
R3756 T6448 T6446 pobj proteins,of
R3757 T6449 T6448 amod pre-synaptic,proteins
R3758 T6450 T6448 amod terminal,proteins
R3759 T6451 T6448 punct ", ",proteins
R3760 T6452 T6448 prep including,proteins
R3761 T6453 T6452 pobj KIF3a,including
R3762 T6454 T6453 punct ", ",KIF3a
R3763 T6455 T6453 conj SV2,KIF3a
R3764 T6456 T6455 punct ", ",SV2
R3765 T6457 T6455 cc and,SV2
R3766 T6458 T6455 conj synaptophysin,SV2
R3767 T6459 T6440 punct ", ",examined
R3768 T6460 T6440 cc and,examined
R3769 T6461 T6440 conj were,examined
R3770 T6462 T6461 acomp unable,were
R3771 T6463 T6464 aux to,observe
R3772 T6464 T6462 xcomp observe,unable
R3773 T6465 T6466 amod qualitative,differences
R3774 T6466 T6464 dobj differences,observe
R3775 T6467 T6466 prep between,differences
R3776 T6468 T6469 nmod Crx,tissue
R3777 T6469 T6467 pobj tissue,between
R3778 T6470 T6468 punct -,Crx
R3779 T6471 T6468 punct /,Crx
R3780 T6472 T6468 punct -,Crx
R3781 T6473 T6468 cc and,Crx
R3782 T6474 T6468 conj control,Crx
R3783 T6475 T6464 prep at,observe
R3784 T6476 T6475 pobj P14,at
R3785 T6477 T6478 punct (,shown
R3786 T6478 T6464 parataxis shown,observe
R3787 T6479 T6478 nsubj data,shown
R3788 T6480 T6478 neg not,shown
R3789 T6481 T6478 punct ),shown
R3790 T6482 T6440 punct .,examined
R3791 T6484 T6485 nsubj Examination,showed
R3792 T6486 T6484 prep of,Examination
R3793 T6487 T6488 poss their,levels
R3794 T6488 T6486 pobj levels,of
R3795 T6489 T6488 compound RNA,levels
R3796 T6490 T6484 prep by,Examination
R3797 T6491 T6490 pobj SAGE,by
R3798 T6492 T6493 det no,difference
R3799 T6493 T6485 dobj difference,showed
R3800 T6494 T6493 amod significant,difference
R3801 T6495 T6485 prep for,showed
R3802 T6496 T6497 det all,genes
R3803 T6497 T6495 pobj genes,for
R3804 T6498 T6497 nummod 3,genes
R3805 T6499 T6485 punct ", ",showed
R3806 T6500 T6501 mark though,recovered
R3807 T6501 T6485 advcl recovered,showed
R3808 T6502 T6503 advmod very,few
R3809 T6503 T6504 amod few,tags
R3810 T6504 T6501 nsubjpass tags,recovered
R3811 T6505 T6501 auxpass were,recovered
R3812 T6506 T6501 prep from,recovered
R3813 T6507 T6508 det these,genes
R3814 T6508 T6506 pobj genes,from
R3815 T6509 T6501 cc and,recovered
R3816 T6510 T6511 advmod thus,be
R3817 T6511 T6501 conj be,recovered
R3818 T6512 T6513 det the,analysis
R3819 T6513 T6511 nsubj analysis,be
R3820 T6514 T6513 prep of,analysis
R3821 T6515 T6516 compound RNA,levels
R3822 T6516 T6514 pobj levels,of
R3823 T6517 T6511 aux may,be
R3824 T6518 T6511 neg not,be
R3825 T6519 T6511 acomp significant,be
R3826 T6520 T6521 punct [,35
R3827 T6521 T6511 parataxis 35,be
R3828 T6522 T6521 punct ],35
R3829 T6523 T6485 punct .,showed
R3830 T6525 T6526 advmod However,are
R3831 T6527 T6526 punct ", ",are
R3832 T6528 T6529 mark since,altered
R3833 T6529 T6526 advcl altered,are
R3834 T6530 T6531 amod other,genes
R3835 T6531 T6529 nsubjpass genes,altered
R3836 T6532 T6531 acl expressed,genes
R3837 T6533 T6532 prep in,expressed
R3838 T6534 T6533 pobj photoreceptors,in
R3839 T6535 T6529 auxpass were,altered
R3840 T6536 T6529 advmod significantly,altered
R3841 T6537 T6529 prep in,altered
R3842 T6538 T6539 poss their,level
R3843 T6539 T6537 pobj level,in
R3844 T6540 T6539 compound expression,level
R3845 T6541 T6529 prep in,altered
R3846 T6542 T6543 det the,mouse
R3847 T6543 T6541 pobj mouse,in
R3848 T6544 T6543 nmod Crx,mouse
R3849 T6545 T6544 punct -,Crx
R3850 T6546 T6544 punct /,Crx
R3851 T6547 T6544 punct -,Crx
R3852 T6548 T6526 punct ", ",are
R3853 T6549 T6526 expl there,are
R3854 T6550 T6551 amod many,candidates
R3855 T6551 T6526 attr candidates,are
R3856 T6552 T6553 dep that,be
R3857 T6553 T6551 relcl be,candidates
R3858 T6554 T6553 aux could,be
R3859 T6555 T6553 acomp important,be
R3860 T6556 T6555 prep for,important
R3861 T6557 T6558 compound photoreceptor,morphogenesis
R3862 T6558 T6556 pobj morphogenesis,for
R3863 T6559 T6526 punct .,are
R3864 T6561 T6562 nsubjpass Tags,found
R3865 T6563 T6561 prep from,Tags
R3866 T6564 T6565 nummod three,genes
R3867 T6565 T6563 pobj genes,from
R3868 T6566 T6565 prep from,genes
R3869 T6567 T6566 pobj proteins,from
R3870 T6568 T6567 acl expressed,proteins
R3871 T6569 T6568 prep in,expressed
R3872 T6570 T6571 compound photoreceptor,terminals
R3873 T6571 T6569 pobj terminals,in
R3874 T6572 T6562 auxpass were,found
R3875 T6573 T6574 aux to,decreased
R3876 T6574 T6562 xcomp decreased,found
R3877 T6575 T6574 auxpass be,decreased
R3878 T6576 T6574 prep in,decreased
R3879 T6577 T6578 det a,fashion
R3880 T6578 T6576 pobj fashion,in
R3881 T6579 T6580 advmod statistically,significant
R3882 T6580 T6578 amod significant,fashion
R3883 T6581 T6562 punct ", ",found
R3884 T6582 T6583 advmod namely,substrate
R3885 T6583 T6562 dobj substrate,found
R3886 T6584 T6583 det the,substrate
R3887 T6585 T6586 npadvmod HGF,regulated
R3888 T6586 T6583 amod regulated,substrate
R3889 T6587 T6586 punct -,regulated
R3890 T6588 T6589 compound tyrosine,kinase
R3891 T6589 T6583 compound kinase,substrate
R3892 T6590 T6583 punct ", ",substrate
R3893 T6591 T6592 det the,protein
R3894 T6592 T6583 conj protein,substrate
R3895 T6593 T6592 compound CRIPT,protein
R3896 T6594 T6592 punct ", ",protein
R3897 T6595 T6592 cc and,protein
R3898 T6596 T6592 conj synaptotagmin,protein
R3899 T6597 T6596 nummod 1,synaptotagmin
R3900 T6598 T6599 punct (,Blackshaw
R3901 T6599 T6562 meta Blackshaw,found
R3902 T6600 T6599 cc and,Blackshaw
R3903 T6601 T6599 conj Cepko,Blackshaw
R3904 T6602 T6601 punct ", ",Cepko
R3905 T6603 T6604 amod unpublished,data
R3906 T6604 T6601 conj data,Cepko
R3907 T6605 T6604 punct ),data
R3908 T6606 T6562 punct .,found
R3909 T6608 T6609 det An,example
R3910 T6609 T6610 nsubj example,is
R3911 T6611 T6609 prep of,example
R3912 T6612 T6613 det a,gene
R3913 T6613 T6611 pobj gene,of
R3914 T6614 T6615 dep that,increased
R3915 T6615 T6613 relcl increased,gene
R3916 T6616 T6615 auxpass was,increased
R3917 T6617 T6615 prep in,increased
R3918 T6618 T6619 det the,retina
R3919 T6619 T6617 pobj retina,in
R3920 T6620 T6619 nmod Crx,retina
R3921 T6621 T6620 punct -,Crx
R3922 T6622 T6620 punct /,Crx
R3923 T6623 T6620 punct -,Crx
R3924 T6624 T6610 attr HRG4,is
R3925 T6625 T6624 punct (,HRG4
R3926 T6626 T6627 det a,homologue
R3927 T6627 T6624 appos homologue,HRG4
R3928 T6628 T6627 prep of,homologue
R3929 T6629 T6630 det the,gene
R3930 T6630 T6628 pobj gene,of
R3931 T6631 T6632 compound C.,elegans
R3932 T6632 T6630 compound elegans,gene
R3933 T6633 T6630 compound Unc119,gene
R3934 T6634 T6624 punct ),HRG4
R3935 T6635 T6636 punct (,Blackshaw
R3936 T6636 T6624 meta Blackshaw,HRG4
R3937 T6637 T6636 cc and,Blackshaw
R3938 T6638 T6636 conj Cepko,Blackshaw
R3939 T6639 T6638 punct ", ",Cepko
R3940 T6640 T6641 amod unpublished,data
R3941 T6641 T6638 conj data,Cepko
R3942 T6642 T6641 punct ),data
R3943 T6643 T6644 dep which,encodes
R3944 T6644 T6624 relcl encodes,HRG4
R3945 T6645 T6646 det a,component
R3946 T6646 T6644 dobj component,encodes
R3947 T6647 T6646 prep of,component
R3948 T6648 T6649 det the,synapse
R3949 T6649 T6647 pobj synapse,of
R3950 T6650 T6649 compound ribbon,synapse
R3951 T6651 T6652 punct [,33
R3952 T6652 T6610 parataxis 33,is
R3953 T6653 T6652 punct ],33
R3954 T6654 T6610 punct .,is
R3955 T6656 T6657 det The,fact
R3956 T6657 T6658 nsubj fact,indicate
R3957 T6659 T6660 mark that,upregulated
R3958 T6660 T6657 acl upregulated,fact
R3959 T6661 T6660 nsubjpass it,upregulated
R3960 T6662 T6660 auxpass is,upregulated
R3961 T6663 T6658 aux might,indicate
R3962 T6664 T6665 det a,response
R3963 T6665 T6658 dobj response,indicate
R3964 T6666 T6665 prep to,response
R3965 T6667 T6668 det the,lack
R3966 T6668 T6666 pobj lack,to
R3967 T6669 T6668 prep of,lack
R3968 T6670 T6671 amod proper,structures
R3969 T6671 T6669 pobj structures,of
R3970 T6672 T6671 amod terminal,structures
R3971 T6673 T6658 punct .,indicate
R3972 T6675 T6676 amod Several,genes
R3973 T6676 T6678 nsubj genes,increased
R3974 T6677 T6676 amod other,genes
R3975 T6679 T6676 acl encoding,genes
R3976 T6680 T6681 amod putative,elements
R3977 T6681 T6679 dobj elements,encoding
R3978 T6682 T6681 amod cytoskeletal,elements
R3979 T6683 T6678 advmod also,increased
R3980 T6684 T6678 aux were,increased
R3981 T6685 T6686 punct (,protein
R3982 T6686 T6678 parataxis protein,increased
R3983 T6687 T6686 advmod e.g.,protein
R3984 T6688 T6689 npadvmod microtubule,associated
R3985 T6689 T6686 amod associated,protein
R3986 T6690 T6686 nummod 4,protein
R3987 T6691 T6686 punct ),protein
R3988 T6692 T6678 cc or,increased
R3989 T6693 T6678 conj decreased,increased
R3990 T6694 T6695 punct (,cofilin
R3991 T6695 T6693 parataxis cofilin,decreased
R3992 T6696 T6695 advmod e.g.,cofilin
R3993 T6697 T6695 nummod 1,cofilin
R3994 T6698 T6695 punct ),cofilin
R3995 T6699 T6678 prep in,increased
R3996 T6700 T6701 det the,retina
R3997 T6701 T6699 pobj retina,in
R3998 T6702 T6701 nmod Crx,retina
R3999 T6703 T6702 punct -,Crx
R4000 T6704 T6702 punct /,Crx
R4001 T6705 T6702 punct -,Crx
R4002 T6706 T6678 punct ", ",increased
R4003 T6707 T6678 prep with,increased
R4004 T6708 T6709 compound P,values
R4005 T6709 T6707 pobj values,with
R4006 T6710 T6709 prep of,values
R4007 T6711 T6712 punct <,.005
R4008 T6712 T6710 pobj .005,of
R4009 T6713 T6678 punct .,increased
R4010 T6715 T6716 nsubjpass It,known
R4011 T6717 T6716 auxpass is,known
R4012 T6718 T6716 neg not,known
R4013 T6719 T6720 mark whether,involved
R4014 T6720 T6716 ccomp involved,known
R4015 T6721 T6720 nsubjpass any,involved
R4016 T6722 T6721 prep of,any
R4017 T6723 T6724 det these,genes
R4018 T6724 T6722 pobj genes,of
R4019 T6725 T6720 auxpass are,involved
R4020 T6726 T6720 prep in,involved
R4021 T6727 T6726 pcomp building,in
R4022 T6728 T6727 cc or,building
R4023 T6729 T6727 conj regulating,building
R4024 T6730 T6731 amod synaptic,structures
R4025 T6731 T6729 dobj structures,regulating
R4026 T6732 T6716 punct ", ",known
R4027 T6733 T6716 cc but,known
R4028 T6734 T6735 nsubj they,are
R4029 T6735 T6716 conj are,known
R4030 T6736 T6735 advmod now,are
R4031 T6737 T6735 attr genes,are
R4032 T6738 T6739 dep that,lead
R4033 T6739 T6737 relcl lead,genes
R4034 T6740 T6739 aux might,lead
R4035 T6741 T6739 prep to,lead
R4036 T6742 T6743 det a,understanding
R4037 T6743 T6741 pobj understanding,to
R4038 T6744 T6743 amod better,understanding
R4039 T6745 T6743 prep of,understanding
R4040 T6746 T6747 det the,construction
R4041 T6747 T6745 pobj construction,of
R4042 T6748 T6747 cc and,construction
R4043 T6749 T6747 conj function,construction
R4044 T6750 T6747 prep of,construction
R4045 T6751 T6752 det the,structure
R4046 T6752 T6750 pobj structure,of
R4047 T6753 T6754 advmod relatively,unique
R4048 T6754 T6752 amod unique,structure
R4049 T6755 T6752 prep of,structure
R4050 T6756 T6757 det the,synapse
R4051 T6757 T6755 pobj synapse,of
R4052 T6758 T6757 compound ribbon,synapse
R4053 T6759 T6735 punct .,are