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PMC:548520 / 18846-31548 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
15676071-7207866-12933281 864-866 7207866 denotes 36
15676071-9020854-12933282 885-887 9020854 denotes 29
15676071-6715580-12933283 1431-1433 6715580 denotes 30
15676071-2144827-12933284 1651-1653 2144827 denotes 37
15676071-6771304-12933285 1892-1894 6771304 denotes 38
15676071-8943002-12933286 2116-2118 8943002 denotes 39
15676071-9020854-12933287 2119-2121 9020854 denotes 29
15676071-10802659-12933288 2193-2195 10802659 denotes 40
15676071-10581037-12933289 2424-2426 10581037 denotes 34
15676071-10744971-12933290 2442-2444 10744971 denotes 10
15676071-11733058-12933291 2494-2496 11733058 denotes 35
15676071-1418997-12933292 2830-2832 1418997 denotes 41
15676071-8575336-12933293 3213-3215 8575336 denotes 42
15676071-9020854-12933294 3269-3271 9020854 denotes 29
15676071-9245510-12933295 3316-3318 9245510 denotes 43
15676071-9570804-12933296 4110-4112 9570804 denotes 44
15676071-8575625-12933297 4614-4616 8575625 denotes 45
15676071-11733058-12933298 4877-4879 11733058 denotes 35
15676071-15324661-12933299 5602-5604 15324661 denotes 46
15676071-11850625-12933300 5701-5703 11850625 denotes 47
15676071-12915475-12933301 5844-5846 12915475 denotes 48
15676071-6715580-12933302 6368-6370 6715580 denotes 30
15676071-15161873-12933303 6542-6544 15161873 denotes 49
15676071-6055897-12933304 7193-7195 6055897 denotes 50
15676071-563768-12933305 7196-7198 563768 denotes 51
15676071-11733058-12933306 7973-7975 11733058 denotes 35
15676071-10329014-12933307 8664-8666 10329014 denotes 33
15676071-10531444-12933308 9366-9368 10531444 denotes 52
15676071-11748842-12933309 10475-10477 11748842 denotes 53
15676071-8512479-12933310 10661-10663 8512479 denotes 54
15676071-8541873-12933311 10768-10770 8541873 denotes 55
15676071-11733058-12933312 10958-10960 11733058 denotes 35
15676071-15231395-12933313 11449-11451 15231395 denotes 17
15676071-4051853-12933314 11452-11454 4051853 denotes 56
15676071-14730587-12933315 11938-11940 14730587 denotes 57
15676071-12124981-12933316 12099-12101 12124981 denotes 24

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3987 57-60 PR_EXT:000005904 denotes Crx
T3988 60-61 SO_EXT:sequence_nullness_or_absence denotes -
T3989 62-63 SO_EXT:sequence_nullness_or_absence denotes -
T3990 64-78 CL:0000210 denotes photoreceptors
T3991 99-102 PR_EXT:000005904 denotes Crx
T3992 103-112 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3993 308-311 PR_EXT:000005904 denotes Crx
T3994 311-312 SO_EXT:sequence_nullness_or_absence denotes -
T3995 313-314 SO_EXT:sequence_nullness_or_absence denotes -
T3996 315-321 UBERON:0000966 denotes retina
T3997 348-361 GO:0001750 denotes outer segment
T3998 362-375 GO:0009653 denotes morphogenesis
T3999 438-451 GO:0001750 denotes outer segment
T4000 467-470 PR_EXT:000005904 denotes Crx
T4001 470-471 SO_EXT:sequence_nullness_or_absence denotes -
T4002 472-473 SO_EXT:sequence_nullness_or_absence denotes -
T4003 474-488 CL:0000210 denotes photoreceptors
T4004 524-531 GO:0045202 denotes synapse
T4005 524-541 GO:0007416 denotes synapse formation
T4006 581-595 GO:0007416 denotes synaptogenesis
T4007 609-615 NCBITaxon:33208 denotes animal
T4469 631-634 PR_EXT:000005904 denotes Crx
T4470 634-635 SO_EXT:sequence_nullness_or_absence denotes -
T4471 636-637 SO_EXT:sequence_nullness_or_absence denotes -
T4472 638-652 CL:0000210 denotes photoreceptors
T4473 669-682 GO:0001750 denotes outer segment
T4474 683-696 GO:0009653 denotes morphogenesis
T4475 697-706 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T4476 710-713 PR_EXT:000005904 denotes Crx
T4477 747-751 SO_EXT:0000704 denotes gene
T4478 752-761 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T4479 778-791 GO:0001750 denotes outer segment
T4480 821-825 SO_EXT:sequence_nullness denotes null
T4481 826-835 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T4482 843-853 PR_EXT:peripherin denotes peripherin
T4483 854-857 PR_EXT:000013290 denotes RDS
T4484 858-862 SO_EXT:0000704 denotes gene
T4485 874-883 PR_EXT:000001245 denotes rhodopsin
T4486 910-923 GO:0001750 denotes outer segment
T4487 951-961 PR_EXT:peripherin denotes peripherin
T4488 961-962 SO_EXT:sequence_nullness_or_absence denotes -
T4489 963-964 SO_EXT:sequence_nullness_or_absence denotes -
T4490 969-972 PR_EXT:000005904 denotes Crx
T4491 972-973 SO_EXT:sequence_nullness_or_absence denotes -
T4492 974-975 SO_EXT:sequence_nullness_or_absence denotes -
T4493 976-989 CL:0000210 denotes photoreceptor
T4494 976-1003 GO:0008594 denotes photoreceptor morphogenesis
T4495 1035-1044 GO:0031982 denotes Vesicular
T4496 1059-1062 PR_EXT:000005904 denotes Crx
T4497 1062-1063 SO_EXT:sequence_nullness_or_absence denotes -
T4498 1064-1065 SO_EXT:sequence_nullness_or_absence denotes -
T4499 1066-1080 CL:0000210 denotes photoreceptors
T4500 1146-1149 PR_EXT:000013290 denotes rds
T4501 1150-1160 PR_EXT:peripherin denotes peripherin
T4502 1160-1161 SO_EXT:sequence_nullness_or_absence denotes -
T4503 1162-1163 SO_EXT:sequence_nullness_or_absence denotes -
T4504 1164-1169 NCBITaxon:10088 denotes mouse
T4505 1208-1216 GO:0031982 denotes vesicles
T4506 1233-1245 _FRAGMENT denotes breakdown of
T4507 1260-1269 GO:0030397 denotes membranes
T4508 1246-1269 GO:0042622 denotes outer segment membranes
T4509 1293-1302 GO_EXT:biological_recruitment denotes recruited
T4510 1310-1324 GO:0001750 denotes outer segments
T4511 1343-1353 PR_EXT:peripherin denotes peripherin
T4512 1403-1413 GO:0005902 denotes microvilli
T4513 1417-1429 CL:0000636 denotes Müller cells
T4514 1424-1429 CL_GO_EXT:cell denotes cells
T4515 1554-1563 PR_EXT:000001245 denotes rhodopsin
T4516 1564-1571 CHEBI_PR_EXT:protein denotes protein
T4517 1581-1589 GO:0031982 denotes vesicles
T4518 1632-1641 PR_EXT:000001245 denotes rhodopsin
T4519 1642-1649 CHEBI_SO_EXT:epitope denotes epitope
T4520 1684-1692 GO:0031982 denotes vesicles
T4521 1716-1730 GO:0001917 denotes inner segments
T4522 1757-1771 CL:0000210 denotes photoreceptors
T4523 1790-1796 GO_EXT:biological_growth_entity_or_process denotes growth
T4524 1824-1837 GO:0001750 denotes outer segment
T4525 1868-1885 GO:0032391 denotes connecting cilium
T4526 1921-1931 PR_EXT:peripherin denotes Peripherin
T4527 1932-1935 PR_EXT:000013290 denotes RDS
T4528 1940-1945 PR_EXT:000014157 denotes ROM-1
T4529 1946-1954 CHEBI_PR_EXT:protein denotes proteins
T4530 1956-1965 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4531 1988-1993 PR_EXT:000001119 denotes opsin
T4532 1994-2002 CHEBI_PR_EXT:protein denotes proteins
T4533 2004-2013 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4534 2095-2109 GO:0001750 denotes outer segments
T4535 2125-2130 PR_EXT:000014157 denotes ROM-1
T4536 2130-2131 SO_EXT:sequence_nullness_or_absence denotes -
T4537 2132-2133 SO_EXT:sequence_nullness_or_absence denotes -
T4538 2134-2138 NCBITaxon:10088 denotes mice
T4539 2160-2174 GO:0001750 denotes outer segments
T4540 2198-2201 PR_EXT:000005904 denotes Crx
T4541 2224-2237 GO_EXT:transcription denotes transcription
T4542 2224-2244 GO_EXT:transcription_factor denotes transcription factor
T4543 2257-2265 GO:0065007 denotes controls
T4544 2266-2271 SO_EXT:0000704 denotes genes
T4545 2341-2354 GO:0001750 denotes outer segment
T4546 2376-2385 PR_EXT:000001245 denotes rhodopsin
T4547 2390-2400 PR_EXT:peripherin denotes peripherin
T4548 2470-2474 SO_EXT:0000704 denotes gene
T4549 2470-2485 GO:0010467 denotes gene expression
T4550 2533-2538 SO_EXT:0000704 denotes genes
T4551 2565-2575 GO:0010467 denotes expression
T4552 2585-2588 PR_EXT:000005904 denotes Crx
T4553 2588-2589 SO_EXT:sequence_nullness_or_absence denotes -
T4554 2590-2591 SO_EXT:sequence_nullness_or_absence denotes -
T4555 2592-2596 NCBITaxon:10088 denotes mice
T4556 2612-2621 PR_EXT:000001245 denotes rhodopsin
T4557 2622-2632 GO:0010467 denotes expression
T4558 2660-2663 PR_EXT:000005904 denotes Crx
T4559 2663-2664 SO_EXT:sequence_nullness_or_absence denotes -
T4560 2665-2666 SO_EXT:sequence_nullness_or_absence denotes -
T4561 2667-2674 NCBITaxon:33208 denotes animals
T4562 2680-2690 PR_EXT:peripherin denotes peripherin
T4563 2691-2695 CHEBI_SO_EXT:mRNA denotes mRNA
T4564 2730-2740 SO_EXT:transgenic_entity denotes Transgenic
T4565 2741-2745 NCBITaxon:10088 denotes mice
T4566 2770-2780 GO:0010467 denotes expression
T4567 2784-2793 SO_EXT:wild_type_entity_or_quality denotes wild type
T4568 2794-2803 PR_EXT:000001245 denotes rhodopsin
T4569 2812-2815 CL:0000604 denotes rod
T4570 2877-2886 PR_EXT:000001245 denotes rhodopsin
T4571 2887-2897 GO:0010467 denotes expression
T4572 2926-2935 PR_EXT:000001245 denotes rhodopsin
T4573 2936-2946 GO:0010467 denotes expression
T4574 2997-3007 NCBITaxon:7215 denotes Drosophila
T4575 3012-3022 NCBITaxon:7215 denotes Drosophila
T4576 3024-3033 PR_EXT:000001245 denotes rhodopsin
T4577 3035-3040 PR_EXT:P06002 denotes ninaE
T4578 3045-3054 GO:0010467 denotes expressed
T4579 3058-3075 CL:0000687 denotes photoreceptors R1
T4580 3058-3072 _FRAGMENT denotes photoreceptors
T4581 3076-3078 CL:0000705 denotes R6
T4582 3083-3088 PR_EXT:P06002 denotes ninaE
T4583 3089-3093 SO_EXT:sequence_nullness denotes null
T4584 3094-3101 SO_EXT:sequence_altered_entity denotes mutants
T4585 3107-3117 GO:0016028 denotes rhabdomere
T4586 3144-3154 NCBITaxon:7742 denotes vertebrate
T4587 3155-3169 GO:0001750 denotes outer segments
T4588 3191-3193 _FRAGMENT denotes R1
T4589 3197-3211 CL:0000687 denotes photoreceptors
T4590 3194-3211 CL:0000705 denotes R6 photoreceptors
T4591 3250-3259 PR_EXT:000001245 denotes rhodopsin
T4592 3259-3260 SO_EXT:sequence_nullness_or_absence denotes -
T4593 3261-3262 SO_EXT:sequence_nullness_or_absence denotes -
T4594 3263-3267 NCBITaxon:10088 denotes mice
T4595 3360-3369 PR_EXT:000001245 denotes rhodopsin
T4596 3370-3380 GO:0010467 denotes expression
T4597 3388-3398 GO:0016028 denotes rhabdomere
T4598 3388-3410 GO:0042052 denotes rhabdomere development
T4599 3415-3420 PR_EXT:P06002 denotes ninaE
T4600 3421-3425 SO_EXT:sequence_nullness denotes null
T4601 3426-3431 NCBITaxon:7147 denotes flies
T4602 3435-3440 PR_EXT:P06002 denotes ninaE
T4603 3441-3450 SO_EXT:0000902 denotes transgene
T4604 3461-3468 GO:0065007 denotes control
T4605 3485-3493 SO_EXT:0000167 denotes promoter
T4606 3595-3604 PR_EXT:000001245 denotes rhodopsin
T4607 3652-3658 SO_EXT:sequence_rescue_process denotes rescue
T4608 3662-3675 CL:0000210 denotes photoreceptor
T4609 3700-3706 SO_EXT:sequence_rescue_process denotes rescue
T4610 3710-3723 CL:0000210 denotes photoreceptor
T4611 3724-3734 GO_PATO_EXT:physiological_process_or_quality denotes physiology
T4612 3745-3755 GO:0010467 denotes expression
T4613 3811-3817 SO_EXT:sequence_rescue_process denotes rescue
T4614 3835-3844 PR_EXT:000001245 denotes rhodopsin
T4615 3845-3855 GO:0010467 denotes expression
T4616 3928-3938 GO:0016028 denotes rhabdomere
T4617 3928-3952 GO:0061541 denotes rhabdomere morphogenesis
T4618 4005-4008 NCBITaxon:10114 denotes rat
T4619 4017-4026 PR_EXT:000001245 denotes rhodopsin
T4620 4096-4100 CL:0000604 denotes rods
T4621 4133-4143 GO:0065007 denotes regulation
T4622 4147-4156 PR_EXT:000001245 denotes rhodopsin
T4623 4184-4191 GO:0065007 denotes control
T4624 4215-4228 GO_EXT:positive_regulation denotes up-regulation
T4625 4232-4241 PR_EXT:000001245 denotes rhodopsin
T4626 4265-4268 PR_EXT:000005904 denotes Crx
T4627 4276-4286 GO:0065007 denotes regulating
T4628 4287-4300 GO:0001750 denotes outer segment
T4629 4301-4314 GO:0009653 denotes morphogenesis
T4630 4391-4394 PR_EXT:000005904 denotes Crx
T4631 4407-4417 NCBITaxon:7215 denotes Drosophila
T4632 4421-4424 PR_EXT:P22810 denotes Otd
T4633 4471-4476 SO_EXT:0000704 denotes genes
T4634 4486-4489 PR_EXT:000005904 denotes Crx
T4635 4533-4539 SO_EXT:0001023 denotes allele
T4636 4543-4553 NCBITaxon:7215 denotes Drosophila
T4637 4554-4557 PR_EXT:P22810 denotes otd
T4638 4559-4562 PR_EXT:P22810 denotes otd
T4639 4567-4580 CL:0000210 denotes photoreceptor
T4640 4567-4594 GO:0008594 denotes photoreceptor morphogenesis
T4641 4654-4659 SO_EXT:0000704 denotes genes
T4642 4684-4687 PR_EXT:000005904 denotes Crx
T4643 4704-4713 GO:0010467 denotes expressed
T4644 4738-4741 PR_EXT:000005904 denotes Crx
T4645 4741-4742 SO_EXT:sequence_nullness_or_absence denotes -
T4646 4743-4744 SO_EXT:sequence_nullness_or_absence denotes -
T4647 4745-4751 UBERON:0000966 denotes retina
T4648 4761-4770 PR_EXT:000001245 denotes rhodopsin
T4649 4775-4785 PR_EXT:peripherin denotes peripherin
T4650 4841-4855 CL:0000210 denotes photoreceptors
T4651 4865-4875 GO:0010467 denotes expression
T4652 4895-4902 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T4653 4925-4930 CHEBI:18059 denotes lipid
T4654 4925-4941 GO:0006629 denotes lipid metabolism
T4655 4943-4950 CHEBI_PR_EXT:protein denotes protein
T4656 4943-4958 GO:0006457 denotes protein folding
T4657 4963-4972 GO_EXT:biological_routing_or_transport denotes transport
T4658 5083-5096 GO:0001750 denotes outer segment
T4659 5106-5119 GO:0097617 denotes hybridization
T4660 5126-5132 CHEBI_SO_EXT:molecular_probe denotes probes
T4661 5157-5162 SO_EXT:0000704 denotes genes
T4662 5205-5208 CHEBI_SO_EXT:RNA denotes RNA
T4663 5209-5218 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4664 5226-5239 GO:0001917 denotes inner segment
T4665 5263-5271 CHEBI_PR_EXT:protein denotes proteins
T4666 5272-5280 GO_EXT:biological_routing_or_transport denotes targeted
T4667 5288-5301 GO:0001750 denotes outer segment
T4668 5344-5349 SO_EXT:0000704 denotes genes
T4669 5377-5390 GO:0001750 denotes outer segment
T4670 5391-5401 GO_EXT:biogenesis_or_biosynthesis denotes biogenesis
T4671 5428-5442 CL:0000210 denotes photoreceptors
T4672 5482-5494 GO:0042384 denotes ciliogenesis
T4673 5508-5512 SO_EXT:0000704 denotes gene
T4674 5514-5518 PR_EXT:000005848 denotes CRB1
T4675 5534-5538 SO_EXT:0000704 denotes gene
T4676 5539-5543 PR_EXT:000005850 denotes CRB3
T4677 5569-5581 GO:0042384 denotes ciliogenesis
T4678 5611-5621 NCBITaxon:7215 denotes Drosophila
T4679 5622-5631 SO_EXT:0000853 denotes homologue
T4680 5635-5639 PR_EXT:000005848 denotes CRB1
T4681 5641-5647 PR_EXT:P10040 denotes Crumbs
T4682 5672-5685 CL:0000210 denotes photoreceptor
T4683 5672-5699 GO:0008594 denotes photoreceptor morphogenesis
T4684 5743-5748 NCBITaxon:10088 denotes mouse
T4685 5749-5755 SO_EXT:sequence_altered_entity denotes mutant
T4686 5759-5763 PR_EXT:000005848 denotes CRB1
T4687 5773-5778 NCBITaxon:10088 denotes mouse
T4688 5799-5813 GO:0001750 denotes outer segments
T4689 5865-5878 CL:0000210 denotes photoreceptor
T4690 5896-5910 GO:0007416 denotes synaptogenesis
T4691 5930-5936 SO_EXT:sequence_altered_entity denotes mutant
T4692 5944-5948 PR_EXT:000005848 denotes CRB1
T4693 5953-5956 PR_EXT:000005904 denotes Crx
T4694 6057-6064 UBERON:0000966 denotes retinal
T4695 6057-6076 GO:0060041 denotes retinal development
T5991 6079-6093 GO:0007416 denotes Synaptogenesis
T5992 6110-6113 PR_EXT:000005904 denotes Crx
T5993 6113-6114 SO_EXT:sequence_nullness_or_absence denotes -
T5994 6115-6116 SO_EXT:sequence_nullness_or_absence denotes -
T5995 6117-6131 CL:0000210 denotes photoreceptors
T5996 6136-6139 PR_EXT:000005904 denotes Crx
T5997 6139-6140 SO_EXT:sequence_nullness_or_absence denotes -
T5998 6141-6142 SO_EXT:sequence_nullness_or_absence denotes -
T5999 6143-6148 NCBITaxon:10088 denotes mouse
T6000 6193-6206 CL:0000210 denotes photoreceptor
T6001 6207-6215 GO:0045202 denotes synapses
T6002 6238-6248 PR_EXT:peripherin denotes peripherin
T6003 6248-6249 SO_EXT:sequence_nullness_or_absence denotes -
T6004 6250-6251 SO_EXT:sequence_nullness_or_absence denotes -
T6005 6252-6257 NCBITaxon:10088 denotes mouse
T6006 6290-6303 CL:0000210 denotes photoreceptor
T6007 6304-6313 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6008 6343-6357 CL:0000210 denotes photoreceptors
T6009 6392-6401 PR_EXT:000001245 denotes rhodopsin
T6010 6403-6406 PR_EXT:000001245 denotes Rho
T6011 6412-6429 CHEBI:23447 denotes cyclic nucleotide
T6012 6412-6452 PR_EXT:000000696 denotes cyclic nucleotide-gated channel, alpha-3
T6013 6430-6443 GO_EXT:0022836 denotes gated channel
T6014 6454-6459 PR_EXT:000000696 denotes CNGA3
T6015 6477-6481 NCBITaxon:10088 denotes mice
T6016 6483-6486 PR_EXT:000001245 denotes Rho
T6017 6486-6487 SO_EXT:sequence_nullness_or_absence denotes -
T6018 6488-6489 SO_EXT:sequence_nullness_or_absence denotes -
T6019 6491-6496 PR_EXT:000000696 denotes CNGA3
T6020 6496-6497 SO_EXT:sequence_nullness_or_absence denotes -
T6021 6498-6499 SO_EXT:sequence_nullness_or_absence denotes -
T6022 6502-6510 GO:0045202 denotes synapses
T6023 6583-6596 CL:0000210 denotes photoreceptor
T6024 6597-6611 GO:0007416 denotes synaptogenesis
T6025 6640-6653 GO:0001750 denotes outer segment
T6026 6761-6771 PR_EXT:peripherin denotes peripherin
T6027 6771-6772 SO_EXT:sequence_nullness_or_absence denotes -
T6028 6773-6774 SO_EXT:sequence_nullness_or_absence denotes -
T6029 6775-6779 NCBITaxon:10088 denotes mice
T6030 6805-6822 GO:0007602 denotes phototransduction
T6031 6843-6847 NCBITaxon:10088 denotes mice
T6032 6881-6894 CL:0000210 denotes photoreceptor
T6033 6895-6902 GO:0045202 denotes synapse
T6034 6929-6945 GO:0044456 denotes synapse elements
T6035 6982-6995 GO:0001750 denotes outer segment
T6036 7060-7073 CL:0000210 denotes photoreceptor
T6037 7119-7136 GO:0007602 denotes phototransduction
T6038 7141-7148 GO:0045202 denotes synapse
T6039 7141-7158 GO:0007416 denotes synapse formation
T6040 7248-7251 PR_EXT:000005904 denotes Crx
T6041 7251-7252 SO_EXT:sequence_nullness_or_absence denotes -
T6042 7253-7254 SO_EXT:sequence_nullness_or_absence denotes -
T6043 7255-7269 CL:0000210 denotes photoreceptors
T6044 7289-7297 GO:0045202 denotes synaptic
T6045 7298-7305 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T6046 7330-7343 GO:0001750 denotes outer segment
T6047 7389-7392 PR_EXT:000005904 denotes Crx
T6048 7409-7422 CL:0000210 denotes photoreceptor
T6049 7423-7430 GO:0045202 denotes synapse
T6050 7423-7440 GO:0007416 denotes synapse formation
T6051 7453-7463 GO:0065007 denotes regulating
T6052 7499-7504 SO_EXT:0000704 denotes genes
T6053 7566-7576 GO:0010467 denotes expression
T6054 7587-7599 GO:0098793 denotes pre-synaptic
T6055 7600-7608 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6056 7609-7617 CHEBI_PR_EXT:protein denotes proteins
T6057 7629-7634 PR_EXT:000009311 denotes KIF3a
T6058 7636-7639 PR_EXT:000015849 denotes SV2
T6059 7645-7658 PR_EXT:000015890 denotes synaptophysin
T6060 7719-7722 PR_EXT:000005904 denotes Crx
T6061 7722-7723 SO_EXT:sequence_nullness_or_absence denotes -
T6062 7724-7725 SO_EXT:sequence_nullness_or_absence denotes -
T6063 7738-7744 UBERON:0000479 denotes tissue
T6064 7791-7794 CHEBI_SO_EXT:RNA denotes RNA
T6065 7853-7858 SO_EXT:0000704 denotes genes
T6066 7876-7880 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes tags
T6067 7907-7912 SO_EXT:0000704 denotes genes
T6068 7938-7941 CHEBI_SO_EXT:RNA denotes RNA
T6069 7999-8004 SO_EXT:0000704 denotes genes
T6070 8005-8014 GO:0010467 denotes expressed
T6071 8018-8032 CL:0000210 denotes photoreceptors
T6072 8069-8079 GO:0010467 denotes expression
T6073 8093-8096 PR_EXT:000005904 denotes Crx
T6074 8096-8097 SO_EXT:sequence_nullness_or_absence denotes -
T6075 8098-8099 SO_EXT:sequence_nullness_or_absence denotes -
T6076 8100-8105 NCBITaxon:10088 denotes mouse
T6077 8161-8174 CL:0000210 denotes photoreceptor
T6078 8161-8188 GO:0008594 denotes photoreceptor morphogenesis
T6079 8190-8194 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes Tags
T6080 8206-8211 SO_EXT:0000704 denotes genes
T6081 8217-8225 CHEBI_PR_EXT:protein denotes proteins
T6082 8226-8235 GO:0010467 denotes expressed
T6083 8239-8252 CL:0000210 denotes photoreceptor
T6084 8253-8262 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6085 8341-8380 PR_EXT:000008536 denotes HGF-regulated tyrosine kinase substrate
T6086 8345-8354 GO:0065007 denotes regulated
T6087 8355-8363 CHEBI_SO_EXT:tyrosine denotes tyrosine
T6088 8355-8370 GO_EXT:0004713 denotes tyrosine kinase
T6089 8386-8391 PR_EXT:000005877 denotes CRIPT
T6090 8392-8399 CHEBI_PR_EXT:protein denotes protein
T6091 8405-8420 PR_EXT:000015894 denotes synaptotagmin 1
T6092 8478-8482 SO_EXT:0000704 denotes gene
T6093 8509-8512 PR_EXT:000005904 denotes Crx
T6094 8512-8513 SO_EXT:sequence_nullness_or_absence denotes -
T6095 8514-8515 SO_EXT:sequence_nullness_or_absence denotes -
T6096 8516-8522 UBERON:0000966 denotes retina
T6097 8526-8530 PR_EXT:000017084 denotes HRG4
T6098 8534-8543 SO_EXT:0000853 denotes homologue
T6099 8551-8561 NCBITaxon:6239 denotes C. elegans
T6100 8562-8568 PR_EXT:Q10658 denotes Unc119
T6101 8569-8573 SO_EXT:0000704 denotes gene
T6102 8621-8628 SO_EXT:sequence_coding_function denotes encodes
T6103 8648-8662 GO:0097470 denotes ribbon synapse
T6104 8689-8700 GO_EXT:positive_regulation denotes upregulated
T6105 8718-8726 GO_EXT:reaction_or_response denotes response
T6106 8749-8757 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6107 8784-8789 SO_EXT:0000704 denotes genes
T6108 8790-8798 SO_EXT:sequence_coding_function denotes encoding
T6109 8808-8829 GO:0044430 denotes cytoskeletal elements
T6110 8856-8867 GO:0005874 denotes microtubule
T6111 8856-8888 PR_EXT:000010142 denotes microtubule associated protein 4
T6112 8879-8886 CHEBI_PR_EXT:protein denotes protein
T6113 8909-8918 PR_EXT:000005385 denotes cofilin 1
T6114 8927-8930 PR_EXT:000005904 denotes Crx
T6115 8930-8931 SO_EXT:sequence_nullness_or_absence denotes -
T6116 8932-8933 SO_EXT:sequence_nullness_or_absence denotes -
T6117 8934-8940 UBERON:0000966 denotes retina
T6118 9003-9008 SO_EXT:0000704 denotes genes
T6119 9037-9047 GO:0065007 denotes regulating
T6120 9048-9056 GO:0045202 denotes synaptic
T6121 9086-9091 SO_EXT:0000704 denotes genes
T6122 9209-9223 GO:0097470 denotes ribbon synapse
T6123 9234-9247 CL:0000210 denotes photoreceptor
T6124 9248-9256 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6125 9302-9309 UBERON:0000966 denotes retinal
T6126 9302-9321 GO:0060041 denotes retinal development
T6127 9329-9348 PR_EXT:000009655 denotes laminin beta2 chain
T6128 9359-9364 NCBITaxon:10088 denotes mouse
T6129 9411-9415 NCBITaxon:10088 denotes mice
T6130 9424-9443 PR_EXT:000009655 denotes laminin beta2 chain
T6131 9454-9458 NCBITaxon:10088 denotes mice
T6132 9478-9491 GO:0001750 denotes outer segment
T6133 9547-9550 PR_EXT:000005904 denotes Crx
T6134 9550-9551 SO_EXT:sequence_nullness_or_absence denotes -
T6135 9552-9553 SO_EXT:sequence_nullness_or_absence denotes -
T6136 9554-9558 NCBITaxon:10088 denotes mice
T6137 9564-9578 GO:0001750 denotes outer segments
T6138 9615-9628 CL:0000210 denotes photoreceptor
T6139 9629-9638 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6140 9657-9670 PR_EXT:000009655 denotes laminin beta2
T6141 9671-9678 SO_EXT:sequence_altered_entity denotes mutants
T6142 9733-9736 PR_EXT:000005904 denotes Crx
T6143 9736-9737 SO_EXT:sequence_nullness_or_absence denotes -
T6144 9738-9739 SO_EXT:sequence_nullness_or_absence denotes -
T6145 9740-9744 NCBITaxon:10088 denotes mice
T6146 9750-9774 _FRAGMENT denotes outer plexiform layer of
T6147 9795-9802 UBERON:0001790 denotes retinas
T6148 9779-9784 PR_EXT:000009655 denotes beta2
T6149 9844-9852 GO:0045202 denotes synapses
T6150 9918-9926 GO:0045202 denotes synaptic
T6151 9992-10001 CHEBI:36357 denotes molecules
T6152 10014-10027 CL:0000210 denotes photoreceptor
T6153 10014-10041 GO:0008594 denotes photoreceptor morphogenesis
T6154 10066-10070 CHEBI_SO_EXT:mRNA denotes mRNA
T6155 10075-10088 PR_EXT:000009655 denotes laminin beta2
T6156 10140-10143 CHEBI_SO_EXT:RNA denotes RNA
T6157 10154-10157 PR_EXT:000005904 denotes Crx
T6158 10157-10158 SO_EXT:sequence_nullness_or_absence denotes -
T6159 10159-10160 SO_EXT:sequence_nullness_or_absence denotes -
T6160 10165-10168 PR_EXT:000005904 denotes Crx
T6161 10168-10169 SO_EXT:normal_or_wild_type_or_present denotes +
T6162 10170-10171 SO_EXT:normal_or_wild_type_or_present denotes +
T6163 10224-10227 CHEBI_SO_EXT:RNA denotes RNA
T6164 10232-10245 PR_EXT:000009655 denotes laminin beta2
T7081 10261-10264 PR_EXT:000005904 denotes Crx
T7082 10264-10265 SO_EXT:sequence_nullness_or_absence denotes -
T7083 10266-10267 SO_EXT:sequence_nullness_or_absence denotes -
T7084 10268-10272 NCBITaxon:10088 denotes mice
T7085 10293-10296 PR_EXT:000005904 denotes Crx
T7086 10326-10339 CL:0000210 denotes photoreceptor
T7087 10364-10369 NCBITaxon:9606 denotes human
T7088 10381-10385 CL:0000573 denotes cone
T7089 10386-10389 CL:0000604 denotes rod
T7090 10485-10489 CL:0000573 denotes cone
T7091 10490-10493 CL:0000604 denotes rod
T7092 10542-10546 CL:0000573 denotes cone
T7093 10556-10562 GO:0007601 denotes vision
T7094 10586-10590 UBERON:0000104 denotes life
T7095 10640-10643 CL:0000604 denotes rod
T7096 10653-10659 GO:0007601 denotes vision
T7097 10712-10715 CL:0000604 denotes rod
T7098 10746-10750 CL:0000573 denotes cone
T7099 10760-10766 GO:0007601 denotes vision
T7100 10795-10800 SO_EXT:0000704 denotes genes
T7101 10817-10822 NCBITaxon:9606 denotes human
T7102 10823-10830 SO_EXT:0000704 denotes genetic
T7103 10842-10848 SO_EXT:sequence_coding_function denotes encode
T7104 10849-10857 CHEBI_PR_EXT:protein denotes proteins
T7105 10858-10867 GO:0010467 denotes expressed
T7106 10907-10921 CL:0000210 denotes photoreceptors
T7107 10943-10956 GO:0001750 denotes outer segment
T7108 10977-10985 CHEBI_PR_EXT:protein denotes proteins
T7109 11003-11020 GO:0007602 denotes phototransduction
T7110 11024-11037 GO:0001750 denotes outer segment
T7111 11072-11081 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7112 11085-11088 CL:0000604 denotes rod
T7113 11098-11103 SO_EXT:0000704 denotes genes
T7114 11113-11122 PR_EXT:000001245 denotes rhodopsin
T7115 11143-11147 CL:0000573 denotes cone
T7116 11183-11192 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T7117 11196-11199 PR_EXT:000005904 denotes Crx
T7118 11258-11271 GO_EXT:transcription denotes transcription
T7119 11258-11278 GO_EXT:transcription_factor denotes transcription factor
T7120 11279-11287 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T7121 11299-11312 CL:0000210 denotes photoreceptor
T7122 11370-11383 CL:0000210 denotes photoreceptor
T7123 11473-11476 PR_EXT:000005904 denotes Crx
T7124 11476-11477 SO_EXT:sequence_nullness_or_absence denotes -
T7125 11478-11479 SO_EXT:sequence_nullness_or_absence denotes -
T7126 11480-11485 NCBITaxon:10088 denotes mouse
T7127 11604-11607 PR_EXT:000005904 denotes Crx
T7128 11608-11617 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7129 11689-11694 NCBITaxon:9606 denotes human
T7130 11695-11701 UBERON:0000479 denotes tissue
T7131 11725-11730 UBERON:0007023 denotes adult
T7132 11809-11815 NCBITaxon:33208 denotes animal
T7133 11909-11921 _FRAGMENT denotes formation of
T7134 11930-11936 GO:0009888 denotes tissue
T7135 11922-11929 UBERON:0000966 denotes retinal
T7136 11930-11936 UBERON:0000479 denotes tissue
T7137 11961-11966 NCBITaxon:9606 denotes human
T7138 11967-11973 UBERON:0000479 denotes tissue
T7139 11989-11994 NCBITaxon:9606 denotes human
T7140 12003-12009 UBERON:0000966 denotes retina
T7141 12024-12029 PR_EXT:000014179 denotes RPE65
T7142 12030-12039 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7143 12070-12077 UBERON:0000966 denotes retinae
T7144 12125-12129 CL_GO_EXT:cell denotes cell
T7145 12162-12175 CL:0000210 denotes photoreceptor
T7146 12162-12181 UBERON:0001787 denotes photoreceptor layer
T7147 12241-12249 GO:0045202 denotes synaptic
T7148 12260-12267 UBERON:0000966 denotes retinal
T7149 12312-12325 CL:0000210 denotes photoreceptor
T7150 12326-12334 GO:0045202 denotes synapses
T7151 12433-12438 NCBITaxon:9606 denotes human
T7152 12439-12445 UBERON:0000479 denotes tissue
T7153 12513-12519 NCBITaxon:33208 denotes animal
T7154 12598-12611 GO:0001750 denotes outer segment
T7155 12612-12625 GO:0009653 denotes morphogenesis
T7156 12627-12641 GO:0007416 denotes synaptogenesis
R2521 T4507 T4506 _lexicallyChainedTo membranes,breakdown of
R2522 T4581 T4580 _lexicallyChainedTo R6,photoreceptors
R2523 T4589 T4588 _lexicallyChainedTo photoreceptors,R1
R3491 T6147 T6146 _lexicallyChainedTo retinas,outer plexiform layer of
R4245 T7134 T7133 _lexicallyChainedTo tissue,formation of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3973 57-60 PR:000005904 denotes Crx
T3974 64-78 CL:0000210 denotes photoreceptors
T3975 99-102 PR:000005904 denotes Crx
T3976 308-311 PR:000005904 denotes Crx
T3977 315-321 UBERON:0000966 denotes retina
T3978 348-361 GO:0001750 denotes outer segment
T3979 362-375 GO:0009653 denotes morphogenesis
T3980 438-451 GO:0001750 denotes outer segment
T3981 467-470 PR:000005904 denotes Crx
T3982 474-488 CL:0000210 denotes photoreceptors
T3983 524-531 GO:0045202 denotes synapse
T3984 524-541 GO:0007416 denotes synapse formation
T3985 581-595 GO:0007416 denotes synaptogenesis
T3986 609-615 NCBITaxon:33208 denotes animal
T4307 631-634 PR:000005904 denotes Crx
T4308 638-652 CL:0000210 denotes photoreceptors
T4309 669-682 GO:0001750 denotes outer segment
T4310 683-696 GO:0009653 denotes morphogenesis
T4311 710-713 PR:000005904 denotes Crx
T4312 747-751 SO:0000704 denotes gene
T4313 778-791 GO:0001750 denotes outer segment
T4314 854-857 PR:000013290 denotes RDS
T4315 858-862 SO:0000704 denotes gene
T4316 874-883 PR:000001245 denotes rhodopsin
T4317 910-923 GO:0001750 denotes outer segment
T4318 969-972 PR:000005904 denotes Crx
T4319 976-989 CL:0000210 denotes photoreceptor
T4320 976-1003 GO:0008594 denotes photoreceptor morphogenesis
T4321 1035-1044 GO:0031982 denotes Vesicular
T4322 1059-1062 PR:000005904 denotes Crx
T4323 1066-1080 CL:0000210 denotes photoreceptors
T4324 1146-1149 PR:000013290 denotes rds
T4325 1164-1169 NCBITaxon:10088 denotes mouse
T4326 1208-1216 GO:0031982 denotes vesicles
T4327 1233-1245 _FRAGMENT denotes breakdown of
T4328 1260-1269 GO:0030397 denotes membranes
T4329 1246-1269 GO:0042622 denotes outer segment membranes
T4330 1310-1324 GO:0001750 denotes outer segments
T4331 1403-1413 GO:0005902 denotes microvilli
T4332 1417-1429 CL:0000636 denotes Müller cells
T4333 1554-1563 PR:000001245 denotes rhodopsin
T4334 1581-1589 GO:0031982 denotes vesicles
T4335 1632-1641 PR:000001245 denotes rhodopsin
T4336 1684-1692 GO:0031982 denotes vesicles
T4337 1716-1730 GO:0001917 denotes inner segments
T4338 1757-1771 CL:0000210 denotes photoreceptors
T4339 1824-1837 GO:0001750 denotes outer segment
T4340 1868-1885 GO:0032391 denotes connecting cilium
T4341 1932-1935 PR:000013290 denotes RDS
T4342 1940-1945 PR:000014157 denotes ROM-1
T4343 1988-1993 PR:000001119 denotes opsin
T4344 2095-2109 GO:0001750 denotes outer segments
T4345 2125-2130 PR:000014157 denotes ROM-1
T4346 2134-2138 NCBITaxon:10088 denotes mice
T4347 2160-2174 GO:0001750 denotes outer segments
T4348 2198-2201 PR:000005904 denotes Crx
T4349 2257-2265 GO:0065007 denotes controls
T4350 2266-2271 SO:0000704 denotes genes
T4351 2341-2354 GO:0001750 denotes outer segment
T4352 2376-2385 PR:000001245 denotes rhodopsin
T4353 2470-2474 SO:0000704 denotes gene
T4354 2470-2485 GO:0010467 denotes gene expression
T4355 2533-2538 SO:0000704 denotes genes
T4356 2565-2575 GO:0010467 denotes expression
T4357 2585-2588 PR:000005904 denotes Crx
T4358 2592-2596 NCBITaxon:10088 denotes mice
T4359 2612-2621 PR:000001245 denotes rhodopsin
T4360 2622-2632 GO:0010467 denotes expression
T4361 2660-2663 PR:000005904 denotes Crx
T4362 2667-2674 NCBITaxon:33208 denotes animals
T4363 2741-2745 NCBITaxon:10088 denotes mice
T4364 2770-2780 GO:0010467 denotes expression
T4365 2794-2803 PR:000001245 denotes rhodopsin
T4366 2812-2815 CL:0000604 denotes rod
T4367 2877-2886 PR:000001245 denotes rhodopsin
T4368 2887-2897 GO:0010467 denotes expression
T4369 2926-2935 PR:000001245 denotes rhodopsin
T4370 2936-2946 GO:0010467 denotes expression
T4371 2997-3007 NCBITaxon:7215 denotes Drosophila
T4372 3012-3022 NCBITaxon:7215 denotes Drosophila
T4373 3024-3033 PR:000001245 denotes rhodopsin
T4374 3035-3040 PR:P06002 denotes ninaE
T4375 3045-3054 GO:0010467 denotes expressed
T4376 3058-3075 CL:0000687 denotes photoreceptors R1
T4377 3058-3072 _FRAGMENT denotes photoreceptors
T4378 3076-3078 CL:0000705 denotes R6
T4379 3083-3088 PR:P06002 denotes ninaE
T4380 3107-3117 GO:0016028 denotes rhabdomere
T4381 3144-3154 NCBITaxon:7742 denotes vertebrate
T4382 3155-3169 GO:0001750 denotes outer segments
T4383 3191-3193 _FRAGMENT denotes R1
T4384 3197-3211 CL:0000687 denotes photoreceptors
T4385 3194-3211 CL:0000705 denotes R6 photoreceptors
T4386 3250-3259 PR:000001245 denotes rhodopsin
T4387 3263-3267 NCBITaxon:10088 denotes mice
T4388 3360-3369 PR:000001245 denotes rhodopsin
T4389 3370-3380 GO:0010467 denotes expression
T4390 3388-3398 GO:0016028 denotes rhabdomere
T4391 3388-3410 GO:0042052 denotes rhabdomere development
T4392 3415-3420 PR:P06002 denotes ninaE
T4393 3426-3431 NCBITaxon:7147 denotes flies
T4394 3435-3440 PR:P06002 denotes ninaE
T4395 3441-3450 SO:0000902 denotes transgene
T4396 3461-3468 GO:0065007 denotes control
T4397 3485-3493 SO:0000167 denotes promoter
T4398 3595-3604 PR:000001245 denotes rhodopsin
T4399 3662-3675 CL:0000210 denotes photoreceptor
T4400 3710-3723 CL:0000210 denotes photoreceptor
T4401 3745-3755 GO:0010467 denotes expression
T4402 3835-3844 PR:000001245 denotes rhodopsin
T4403 3845-3855 GO:0010467 denotes expression
T4404 3928-3938 GO:0016028 denotes rhabdomere
T4405 3928-3952 GO:0061541 denotes rhabdomere morphogenesis
T4406 4005-4008 NCBITaxon:10114 denotes rat
T4407 4017-4026 PR:000001245 denotes rhodopsin
T4408 4096-4100 CL:0000604 denotes rods
T4409 4133-4143 GO:0065007 denotes regulation
T4410 4147-4156 PR:000001245 denotes rhodopsin
T4411 4184-4191 GO:0065007 denotes control
T4412 4232-4241 PR:000001245 denotes rhodopsin
T4413 4265-4268 PR:000005904 denotes Crx
T4414 4276-4286 GO:0065007 denotes regulating
T4415 4287-4300 GO:0001750 denotes outer segment
T4416 4301-4314 GO:0009653 denotes morphogenesis
T4417 4391-4394 PR:000005904 denotes Crx
T4418 4407-4417 NCBITaxon:7215 denotes Drosophila
T4419 4421-4424 PR:P22810 denotes Otd
T4420 4471-4476 SO:0000704 denotes genes
T4421 4486-4489 PR:000005904 denotes Crx
T4422 4533-4539 SO:0001023 denotes allele
T4423 4543-4553 NCBITaxon:7215 denotes Drosophila
T4424 4554-4557 PR:P22810 denotes otd
T4425 4559-4562 PR:P22810 denotes otd
T4426 4567-4580 CL:0000210 denotes photoreceptor
T4427 4567-4594 GO:0008594 denotes photoreceptor morphogenesis
T4428 4654-4659 SO:0000704 denotes genes
T4429 4684-4687 PR:000005904 denotes Crx
T4430 4704-4713 GO:0010467 denotes expressed
T4431 4738-4741 PR:000005904 denotes Crx
T4432 4745-4751 UBERON:0000966 denotes retina
T4433 4761-4770 PR:000001245 denotes rhodopsin
T4434 4841-4855 CL:0000210 denotes photoreceptors
T4435 4865-4875 GO:0010467 denotes expression
T4436 4925-4930 CHEBI:18059 denotes lipid
T4437 4925-4941 GO:0006629 denotes lipid metabolism
T4438 4943-4958 GO:0006457 denotes protein folding
T4439 5083-5096 GO:0001750 denotes outer segment
T4440 5106-5119 GO:0097617 denotes hybridization
T4441 5157-5162 SO:0000704 denotes genes
T4442 5226-5239 GO:0001917 denotes inner segment
T4443 5288-5301 GO:0001750 denotes outer segment
T4444 5344-5349 SO:0000704 denotes genes
T4445 5377-5390 GO:0001750 denotes outer segment
T4446 5428-5442 CL:0000210 denotes photoreceptors
T4447 5482-5494 GO:0042384 denotes ciliogenesis
T4448 5508-5512 SO:0000704 denotes gene
T4449 5514-5518 PR:000005848 denotes CRB1
T4450 5534-5538 SO:0000704 denotes gene
T4451 5539-5543 PR:000005850 denotes CRB3
T4452 5569-5581 GO:0042384 denotes ciliogenesis
T4453 5611-5621 NCBITaxon:7215 denotes Drosophila
T4454 5622-5631 SO:0000853 denotes homologue
T4455 5635-5639 PR:000005848 denotes CRB1
T4456 5641-5647 PR:P10040 denotes Crumbs
T4457 5672-5685 CL:0000210 denotes photoreceptor
T4458 5672-5699 GO:0008594 denotes photoreceptor morphogenesis
T4459 5743-5748 NCBITaxon:10088 denotes mouse
T4460 5759-5763 PR:000005848 denotes CRB1
T4461 5773-5778 NCBITaxon:10088 denotes mouse
T4462 5799-5813 GO:0001750 denotes outer segments
T4463 5865-5878 CL:0000210 denotes photoreceptor
T4464 5896-5910 GO:0007416 denotes synaptogenesis
T4465 5944-5948 PR:000005848 denotes CRB1
T4466 5953-5956 PR:000005904 denotes Crx
T4467 6057-6064 UBERON:0000966 denotes retinal
T4468 6057-6076 GO:0060041 denotes retinal development
T5875 6079-6093 GO:0007416 denotes Synaptogenesis
T5876 6110-6113 PR:000005904 denotes Crx
T5877 6117-6131 CL:0000210 denotes photoreceptors
T5878 6136-6139 PR:000005904 denotes Crx
T5879 6143-6148 NCBITaxon:10088 denotes mouse
T5880 6193-6206 CL:0000210 denotes photoreceptor
T5881 6207-6215 GO:0045202 denotes synapses
T5882 6252-6257 NCBITaxon:10088 denotes mouse
T5883 6290-6303 CL:0000210 denotes photoreceptor
T5884 6343-6357 CL:0000210 denotes photoreceptors
T5885 6392-6401 PR:000001245 denotes rhodopsin
T5886 6403-6406 PR:000001245 denotes Rho
T5887 6412-6429 CHEBI:23447 denotes cyclic nucleotide
T5888 6412-6452 PR:000000696 denotes cyclic nucleotide-gated channel, alpha-3
T5889 6454-6459 PR:000000696 denotes CNGA3
T5890 6477-6481 NCBITaxon:10088 denotes mice
T5891 6483-6486 PR:000001245 denotes Rho
T5892 6491-6496 PR:000000696 denotes CNGA3
T5893 6502-6510 GO:0045202 denotes synapses
T5894 6583-6596 CL:0000210 denotes photoreceptor
T5895 6597-6611 GO:0007416 denotes synaptogenesis
T5896 6640-6653 GO:0001750 denotes outer segment
T5897 6775-6779 NCBITaxon:10088 denotes mice
T5898 6805-6822 GO:0007602 denotes phototransduction
T5899 6843-6847 NCBITaxon:10088 denotes mice
T5900 6881-6894 CL:0000210 denotes photoreceptor
T5901 6895-6902 GO:0045202 denotes synapse
T5902 6929-6945 GO:0044456 denotes synapse elements
T5903 6982-6995 GO:0001750 denotes outer segment
T5904 7060-7073 CL:0000210 denotes photoreceptor
T5905 7119-7136 GO:0007602 denotes phototransduction
T5906 7141-7148 GO:0045202 denotes synapse
T5907 7141-7158 GO:0007416 denotes synapse formation
T5908 7248-7251 PR:000005904 denotes Crx
T5909 7255-7269 CL:0000210 denotes photoreceptors
T5910 7289-7297 GO:0045202 denotes synaptic
T5911 7330-7343 GO:0001750 denotes outer segment
T5912 7389-7392 PR:000005904 denotes Crx
T5913 7409-7422 CL:0000210 denotes photoreceptor
T5914 7423-7430 GO:0045202 denotes synapse
T5915 7423-7440 GO:0007416 denotes synapse formation
T5916 7453-7463 GO:0065007 denotes regulating
T5917 7499-7504 SO:0000704 denotes genes
T5918 7566-7576 GO:0010467 denotes expression
T5919 7587-7599 GO:0098793 denotes pre-synaptic
T5920 7629-7634 PR:000009311 denotes KIF3a
T5921 7636-7639 PR:000015849 denotes SV2
T5922 7645-7658 PR:000015890 denotes synaptophysin
T5923 7719-7722 PR:000005904 denotes Crx
T5924 7738-7744 UBERON:0000479 denotes tissue
T5925 7853-7858 SO:0000704 denotes genes
T5926 7907-7912 SO:0000704 denotes genes
T5927 7999-8004 SO:0000704 denotes genes
T5928 8005-8014 GO:0010467 denotes expressed
T5929 8018-8032 CL:0000210 denotes photoreceptors
T5930 8069-8079 GO:0010467 denotes expression
T5931 8093-8096 PR:000005904 denotes Crx
T5932 8100-8105 NCBITaxon:10088 denotes mouse
T5933 8161-8174 CL:0000210 denotes photoreceptor
T5934 8161-8188 GO:0008594 denotes photoreceptor morphogenesis
T5935 8206-8211 SO:0000704 denotes genes
T5936 8226-8235 GO:0010467 denotes expressed
T5937 8239-8252 CL:0000210 denotes photoreceptor
T5938 8341-8380 PR:000008536 denotes HGF-regulated tyrosine kinase substrate
T5939 8345-8354 GO:0065007 denotes regulated
T5940 8386-8391 PR:000005877 denotes CRIPT
T5941 8405-8420 PR:000015894 denotes synaptotagmin 1
T5942 8478-8482 SO:0000704 denotes gene
T5943 8509-8512 PR:000005904 denotes Crx
T5944 8516-8522 UBERON:0000966 denotes retina
T5945 8526-8530 PR:000017084 denotes HRG4
T5946 8534-8543 SO:0000853 denotes homologue
T5947 8551-8561 NCBITaxon:6239 denotes C. elegans
T5948 8562-8568 PR:Q10658 denotes Unc119
T5949 8569-8573 SO:0000704 denotes gene
T5950 8648-8662 GO:0097470 denotes ribbon synapse
T5951 8784-8789 SO:0000704 denotes genes
T5952 8808-8829 GO:0044430 denotes cytoskeletal elements
T5953 8856-8867 GO:0005874 denotes microtubule
T5954 8856-8888 PR:000010142 denotes microtubule associated protein 4
T5955 8909-8918 PR:000005385 denotes cofilin 1
T5956 8927-8930 PR:000005904 denotes Crx
T5957 8934-8940 UBERON:0000966 denotes retina
T5958 9003-9008 SO:0000704 denotes genes
T5959 9037-9047 GO:0065007 denotes regulating
T5960 9048-9056 GO:0045202 denotes synaptic
T5961 9086-9091 SO:0000704 denotes genes
T5962 9209-9223 GO:0097470 denotes ribbon synapse
T5963 9234-9247 CL:0000210 denotes photoreceptor
T5964 9302-9309 UBERON:0000966 denotes retinal
T5965 9302-9321 GO:0060041 denotes retinal development
T5966 9329-9348 PR:000009655 denotes laminin beta2 chain
T5967 9359-9364 NCBITaxon:10088 denotes mouse
T5968 9411-9415 NCBITaxon:10088 denotes mice
T5969 9424-9443 PR:000009655 denotes laminin beta2 chain
T5970 9454-9458 NCBITaxon:10088 denotes mice
T5971 9478-9491 GO:0001750 denotes outer segment
T5972 9547-9550 PR:000005904 denotes Crx
T5973 9554-9558 NCBITaxon:10088 denotes mice
T5974 9564-9578 GO:0001750 denotes outer segments
T5975 9615-9628 CL:0000210 denotes photoreceptor
T5976 9657-9670 PR:000009655 denotes laminin beta2
T5977 9733-9736 PR:000005904 denotes Crx
T5978 9740-9744 NCBITaxon:10088 denotes mice
T5979 9750-9774 _FRAGMENT denotes outer plexiform layer of
T5980 9795-9802 UBERON:0001790 denotes retinas
T5981 9779-9784 PR:000009655 denotes beta2
T5982 9844-9852 GO:0045202 denotes synapses
T5983 9918-9926 GO:0045202 denotes synaptic
T5984 9992-10001 CHEBI:36357 denotes molecules
T5985 10014-10027 CL:0000210 denotes photoreceptor
T5986 10014-10041 GO:0008594 denotes photoreceptor morphogenesis
T5987 10075-10088 PR:000009655 denotes laminin beta2
T5988 10154-10157 PR:000005904 denotes Crx
T5989 10165-10168 PR:000005904 denotes Crx
T5990 10232-10245 PR:000009655 denotes laminin beta2
T7020 10261-10264 PR:000005904 denotes Crx
T7021 10268-10272 NCBITaxon:10088 denotes mice
T7022 10293-10296 PR:000005904 denotes Crx
T7023 10326-10339 CL:0000210 denotes photoreceptor
T7024 10364-10369 NCBITaxon:9606 denotes human
T7025 10381-10385 CL:0000573 denotes cone
T7026 10386-10389 CL:0000604 denotes rod
T7027 10485-10489 CL:0000573 denotes cone
T7028 10490-10493 CL:0000604 denotes rod
T7029 10542-10546 CL:0000573 denotes cone
T7030 10556-10562 GO:0007601 denotes vision
T7031 10586-10590 UBERON:0000104 denotes life
T7032 10640-10643 CL:0000604 denotes rod
T7033 10653-10659 GO:0007601 denotes vision
T7034 10712-10715 CL:0000604 denotes rod
T7035 10746-10750 CL:0000573 denotes cone
T7036 10760-10766 GO:0007601 denotes vision
T7037 10795-10800 SO:0000704 denotes genes
T7038 10817-10822 NCBITaxon:9606 denotes human
T7039 10823-10830 SO:0000704 denotes genetic
T7040 10858-10867 GO:0010467 denotes expressed
T7041 10907-10921 CL:0000210 denotes photoreceptors
T7042 10943-10956 GO:0001750 denotes outer segment
T7043 11003-11020 GO:0007602 denotes phototransduction
T7044 11024-11037 GO:0001750 denotes outer segment
T7045 11085-11088 CL:0000604 denotes rod
T7046 11098-11103 SO:0000704 denotes genes
T7047 11113-11122 PR:000001245 denotes rhodopsin
T7048 11143-11147 CL:0000573 denotes cone
T7049 11196-11199 PR:000005904 denotes Crx
T7050 11299-11312 CL:0000210 denotes photoreceptor
T7051 11370-11383 CL:0000210 denotes photoreceptor
T7052 11473-11476 PR:000005904 denotes Crx
T7053 11480-11485 NCBITaxon:10088 denotes mouse
T7054 11604-11607 PR:000005904 denotes Crx
T7055 11689-11694 NCBITaxon:9606 denotes human
T7056 11695-11701 UBERON:0000479 denotes tissue
T7057 11725-11730 UBERON:0007023 denotes adult
T7058 11809-11815 NCBITaxon:33208 denotes animal
T7059 11909-11921 _FRAGMENT denotes formation of
T7060 11930-11936 GO:0009888 denotes tissue
T7061 11922-11929 UBERON:0000966 denotes retinal
T7062 11930-11936 UBERON:0000479 denotes tissue
T7063 11961-11966 NCBITaxon:9606 denotes human
T7064 11967-11973 UBERON:0000479 denotes tissue
T7065 11989-11994 NCBITaxon:9606 denotes human
T7066 12003-12009 UBERON:0000966 denotes retina
T7067 12024-12029 PR:000014179 denotes RPE65
T7068 12070-12077 UBERON:0000966 denotes retinae
T7069 12162-12175 CL:0000210 denotes photoreceptor
T7070 12162-12181 UBERON:0001787 denotes photoreceptor layer
T7071 12241-12249 GO:0045202 denotes synaptic
T7072 12260-12267 UBERON:0000966 denotes retinal
T7073 12312-12325 CL:0000210 denotes photoreceptor
T7074 12326-12334 GO:0045202 denotes synapses
T7075 12433-12438 NCBITaxon:9606 denotes human
T7076 12439-12445 UBERON:0000479 denotes tissue
T7077 12513-12519 NCBITaxon:33208 denotes animal
T7078 12598-12611 GO:0001750 denotes outer segment
T7079 12612-12625 GO:0009653 denotes morphogenesis
T7080 12627-12641 GO:0007416 denotes synaptogenesis
R2518 T4328 T4327 _lexicallyChainedTo membranes,breakdown of
R2519 T4378 T4377 _lexicallyChainedTo R6,photoreceptors
R2520 T4384 T4383 _lexicallyChainedTo photoreceptors,R1
R3490 T5980 T5979 _lexicallyChainedTo retinas,outer plexiform layer of
R4244 T7060 T7059 _lexicallyChainedTo tissue,formation of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T4008 11-13 IN denotes In
T4009 83-90 VBN denotes carried
T4010 14-18 DT denotes this
T4011 19-24 NN denotes study
T4012 24-26 , denotes ,
T4013 26-28 DT denotes an
T4014 45-53 NN denotes analysis
T4015 29-44 JJ denotes ultrastructural
T4016 54-56 IN denotes of
T4017 57-60 NN denotes Crx
T4018 64-78 NNS denotes photoreceptors
T4019 60-61 SYM denotes -
T4020 61-62 HYPH denotes /
T4021 62-63 SYM denotes -
T4022 79-82 VBD denotes was
T4023 91-94 RP denotes out
T4024 94-95 . denotes .
T4025 95-255 sentence denotes As Crx mutations have been associated with Leber's congenital amaurosis, the findings in this study broaden our understanding of the pathology of this disease.
T4026 96-98 IN denotes As
T4027 123-133 VBN denotes associated
T4028 99-102 NN denotes Crx
T4029 103-112 NNS denotes mutations
T4030 113-117 VBP denotes have
T4031 118-122 VBN denotes been
T4032 196-203 VBD denotes broaden
T4033 134-138 IN denotes with
T4034 139-144 NNP denotes Leber
T4035 158-167 NN denotes amaurosis
T4036 144-146 POS denotes 's
T4037 147-157 JJ denotes congenital
T4038 167-169 , denotes ,
T4039 169-172 DT denotes the
T4040 173-181 NNS denotes findings
T4041 182-184 IN denotes in
T4042 185-189 DT denotes this
T4043 190-195 NN denotes study
T4044 204-207 PRP$ denotes our
T4045 208-221 NN denotes understanding
T4046 222-224 IN denotes of
T4047 225-228 DT denotes the
T4048 229-238 NN denotes pathology
T4049 239-241 IN denotes of
T4050 242-246 DT denotes this
T4051 247-254 NN denotes disease
T4052 254-255 . denotes .
T4053 255-542 sentence denotes Two prominent pathologies were characterized in the Crx-/- retina: (1) An absolute block in outer segment morphogenesis was noted, with the block occuring at the elongation stage of outer segment formation; (2) Crx-/- photoreceptors exhibited a severe perturbation in synapse formation.
T4054 256-259 CD denotes Two
T4055 270-281 NNS denotes pathologies
T4056 260-269 JJ denotes prominent
T4057 287-300 VBN denotes characterized
T4058 282-286 VBD denotes were
T4059 489-498 VBD denotes exhibited
T4060 301-303 IN denotes in
T4061 304-307 DT denotes the
T4062 315-321 NN denotes retina
T4063 308-311 NN denotes Crx
T4064 311-312 SYM denotes -
T4065 312-313 HYPH denotes /
T4066 313-314 SYM denotes -
T4067 321-323 : denotes :
T4068 323-324 -LRB- denotes (
T4069 324-325 LS denotes 1
T4070 380-385 VBN denotes noted
T4071 325-326 -RRB- denotes )
T4072 327-329 DT denotes An
T4073 339-344 NN denotes block
T4074 330-338 JJ denotes absolute
T4075 345-347 IN denotes in
T4076 348-353 JJ denotes outer
T4077 354-361 NN denotes segment
T4078 362-375 NN denotes morphogenesis
T4079 376-379 VBD denotes was
T4080 385-387 , denotes ,
T4081 387-391 IN denotes with
T4082 392-395 DT denotes the
T4083 396-401 NN denotes block
T4084 402-410 VBG denotes occuring
T4085 411-413 IN denotes at
T4086 414-417 DT denotes the
T4087 429-434 NN denotes stage
T4088 418-428 NN denotes elongation
T4089 435-437 IN denotes of
T4090 438-443 JJ denotes outer
T4091 444-451 NN denotes segment
T4092 452-461 NN denotes formation
T4093 461-462 : denotes ;
T4094 463-464 -LRB- denotes (
T4095 464-465 LS denotes 2
T4096 465-466 -RRB- denotes )
T4097 467-470 NN denotes Crx
T4098 474-488 NNS denotes photoreceptors
T4099 470-471 SYM denotes -
T4100 471-472 HYPH denotes /
T4101 472-473 SYM denotes -
T4102 499-500 DT denotes a
T4103 508-520 NN denotes perturbation
T4104 501-507 JJ denotes severe
T4105 521-523 IN denotes in
T4106 524-531 NN denotes synapse
T4107 532-541 NN denotes formation
T4108 541-542 . denotes .
T4109 542-629 sentence denotes This represents the first report of a synaptogenesis defect in an animal model of LCA.
T4110 543-547 DT denotes This
T4111 548-558 VBZ denotes represents
T4112 559-562 DT denotes the
T4113 569-575 NN denotes report
T4114 563-568 JJ denotes first
T4115 576-578 IN denotes of
T4116 579-580 DT denotes a
T4117 596-602 NN denotes defect
T4118 581-595 NN denotes synaptogenesis
T4119 603-605 IN denotes in
T4120 606-608 DT denotes an
T4121 616-621 NN denotes model
T4122 609-615 NN denotes animal
T4123 622-624 IN denotes of
T4124 625-628 NN denotes LCA
T4125 628-629 . denotes .
T4696 631-634 NN denotes Crx
T4697 638-652 NNS denotes photoreceptors
T4698 634-635 SYM denotes -
T4699 635-636 HYPH denotes /
T4700 636-637 SYM denotes -
T4701 660-668 VB denotes complete
T4702 653-656 MD denotes can
T4703 656-659 RB denotes not
T4704 669-674 JJ denotes outer
T4705 675-682 NN denotes segment
T4706 683-696 NN denotes morphogenesis
T4707 696-809 sentence denotes Mutations in Crx represent one of a collection of gene mutations that lead to an outer segment formation defect.
T4708 697-706 NNS denotes Mutations
T4709 714-723 VBP denotes represent
T4710 707-709 IN denotes in
T4711 710-713 NN denotes Crx
T4712 724-727 CD denotes one
T4713 728-730 IN denotes of
T4714 731-732 DT denotes a
T4715 733-743 NN denotes collection
T4716 744-746 IN denotes of
T4717 747-751 NN denotes gene
T4718 752-761 NNS denotes mutations
T4719 762-766 WDT denotes that
T4720 767-771 VBP denotes lead
T4721 772-774 IN denotes to
T4722 775-777 DT denotes an
T4723 802-808 NN denotes defect
T4724 778-783 JJ denotes outer
T4725 784-791 NN denotes segment
T4726 792-801 NN denotes formation
T4727 808-809 . denotes .
T4728 809-934 sentence denotes Homozygous null mutations in the peripherin/RDS gene [36] or in rhodopsin [29] lead to a failure of outer segment formation.
T4729 810-820 JJ denotes Homozygous
T4730 826-835 NNS denotes mutations
T4731 821-825 JJ denotes null
T4732 889-893 VBP denotes lead
T4733 836-838 IN denotes in
T4734 839-842 DT denotes the
T4735 858-862 NN denotes gene
T4736 843-853 NN denotes peripherin
T4737 854-857 NN denotes RDS
T4738 853-854 HYPH denotes /
T4739 863-864 -LRB- denotes [
T4740 864-866 CD denotes 36
T4741 866-867 -RRB- denotes ]
T4742 868-870 CC denotes or
T4743 871-873 IN denotes in
T4744 874-883 NN denotes rhodopsin
T4745 884-885 -LRB- denotes [
T4746 885-887 CD denotes 29
T4747 887-888 -RRB- denotes ]
T4748 894-896 IN denotes to
T4749 897-898 DT denotes a
T4750 899-906 NN denotes failure
T4751 907-909 IN denotes of
T4752 910-915 JJ denotes outer
T4753 916-923 NN denotes segment
T4754 924-933 NN denotes formation
T4755 933-934 . denotes .
T4756 934-1034 sentence denotes The deficits in peripherin-/- and Crx-/- photoreceptor morphogenesis were found to be very similar.
T4757 935-938 DT denotes The
T4758 939-947 NNS denotes deficits
T4759 1009-1014 VBN denotes found
T4760 948-950 IN denotes in
T4761 951-961 NN denotes peripherin
T4762 990-1003 NN denotes morphogenesis
T4763 961-962 SYM denotes -
T4764 962-963 HYPH denotes /
T4765 963-964 SYM denotes -
T4766 965-968 CC denotes and
T4767 969-972 NN denotes Crx
T4768 972-973 SYM denotes -
T4769 973-974 HYPH denotes /
T4770 974-975 SYM denotes -
T4771 976-989 NN denotes photoreceptor
T4772 1004-1008 VBD denotes were
T4773 1015-1017 TO denotes to
T4774 1018-1020 VB denotes be
T4775 1021-1025 RB denotes very
T4776 1026-1033 JJ denotes similar
T4777 1033-1034 . denotes .
T4778 1034-1170 sentence denotes Vesicular structures in Crx-/- photoreceptors were observed that were similar to those previously noted in the rds/peripherin-/- mouse.
T4779 1035-1044 JJ denotes Vesicular
T4780 1045-1055 NNS denotes structures
T4781 1086-1094 VBN denotes observed
T4782 1056-1058 IN denotes in
T4783 1059-1062 NN denotes Crx
T4784 1066-1080 NNS denotes photoreceptors
T4785 1062-1063 SYM denotes -
T4786 1063-1064 HYPH denotes /
T4787 1064-1065 SYM denotes -
T4788 1081-1085 VBD denotes were
T4789 1095-1099 WDT denotes that
T4790 1100-1104 VBD denotes were
T4791 1105-1112 JJ denotes similar
T4792 1113-1115 IN denotes to
T4793 1116-1121 DT denotes those
T4794 1122-1132 RB denotes previously
T4795 1133-1138 VBN denotes noted
T4796 1139-1141 IN denotes in
T4797 1142-1145 DT denotes the
T4798 1164-1169 NN denotes mouse
T4799 1146-1149 NN denotes rds
T4800 1150-1160 NN denotes peripherin
T4801 1149-1150 HYPH denotes /
T4802 1160-1161 SYM denotes -
T4803 1161-1162 HYPH denotes /
T4804 1162-1163 SYM denotes -
T4805 1169-1170 . denotes .
T4806 1170-1435 sentence denotes It was initially proposed that these vesicles were due to the breakdown of outer segment membranes that were not properly recruited to the outer segments in the absence of peripherin, or were from the result of the breakdown of the microvilli of Müller cells [30].
T4807 1171-1173 PRP denotes It
T4808 1188-1196 VBN denotes proposed
T4809 1174-1177 VBD denotes was
T4810 1178-1187 RB denotes initially
T4811 1197-1201 IN denotes that
T4812 1217-1221 VBD denotes were
T4813 1202-1207 DT denotes these
T4814 1208-1216 NNS denotes vesicles
T4815 1222-1225 IN denotes due
T4816 1226-1228 IN denotes to
T4817 1229-1232 DT denotes the
T4818 1233-1242 NN denotes breakdown
T4819 1243-1245 IN denotes of
T4820 1246-1251 JJ denotes outer
T4821 1252-1259 NN denotes segment
T4822 1260-1269 NNS denotes membranes
T4823 1270-1274 WDT denotes that
T4824 1293-1302 VBN denotes recruited
T4825 1275-1279 VBD denotes were
T4826 1280-1283 RB denotes not
T4827 1284-1292 RB denotes properly
T4828 1303-1305 IN denotes to
T4829 1306-1309 DT denotes the
T4830 1316-1324 NNS denotes segments
T4831 1310-1315 JJ denotes outer
T4832 1325-1327 IN denotes in
T4833 1328-1331 DT denotes the
T4834 1332-1339 NN denotes absence
T4835 1340-1342 IN denotes of
T4836 1343-1353 NN denotes peripherin
T4837 1353-1355 , denotes ,
T4838 1355-1357 CC denotes or
T4839 1358-1362 VBD denotes were
T4840 1363-1367 IN denotes from
T4841 1368-1371 DT denotes the
T4842 1372-1378 NN denotes result
T4843 1379-1381 IN denotes of
T4844 1382-1385 DT denotes the
T4845 1386-1395 NN denotes breakdown
T4846 1396-1398 IN denotes of
T4847 1399-1402 DT denotes the
T4848 1403-1413 NNS denotes microvilli
T4849 1414-1416 IN denotes of
T4850 1417-1423 NN denotes Müller
T4851 1424-1429 NNS denotes cells
T4852 1430-1431 -LRB- denotes [
T4853 1431-1433 CD denotes 30
T4854 1433-1434 -RRB- denotes ]
T4855 1434-1435 . denotes .
T4856 1435-1655 sentence denotes Strong support in favor of the former explanation was provided by Nir and colleagues who demonstrated the presence of rhodopsin protein in these vesicles using immunoelectron microscopy against a rhodopsin epitope [37].
T4857 1436-1442 JJ denotes Strong
T4858 1443-1450 NN denotes support
T4859 1490-1498 VBN denotes provided
T4860 1451-1453 IN denotes in
T4861 1454-1459 NN denotes favor
T4862 1460-1462 IN denotes of
T4863 1463-1466 DT denotes the
T4864 1474-1485 NN denotes explanation
T4865 1467-1473 JJ denotes former
T4866 1486-1489 VBD denotes was
T4867 1499-1501 IN denotes by
T4868 1502-1505 NN denotes Nir
T4869 1506-1509 CC denotes and
T4870 1510-1520 NNS denotes colleagues
T4871 1521-1524 WP denotes who
T4872 1525-1537 VBD denotes demonstrated
T4873 1538-1541 DT denotes the
T4874 1542-1550 NN denotes presence
T4875 1551-1553 IN denotes of
T4876 1554-1563 NN denotes rhodopsin
T4877 1564-1571 NN denotes protein
T4878 1572-1574 IN denotes in
T4879 1575-1580 DT denotes these
T4880 1581-1589 NNS denotes vesicles
T4881 1590-1595 VBG denotes using
T4882 1596-1610 NN denotes immunoelectron
T4883 1611-1621 NN denotes microscopy
T4884 1622-1629 IN denotes against
T4885 1630-1631 DT denotes a
T4886 1642-1649 NN denotes epitope
T4887 1632-1641 NN denotes rhodopsin
T4888 1650-1651 -LRB- denotes [
T4889 1651-1653 CD denotes 37
T4890 1653-1654 -RRB- denotes ]
T4891 1654-1655 . denotes .
T4892 1655-1742 sentence denotes Further, as shown here, the vesicles appear to bud from the inner segments themselves.
T4893 1656-1663 RB denotes Further
T4894 1693-1699 VBP denotes appear
T4895 1663-1665 , denotes ,
T4896 1665-1667 IN denotes as
T4897 1668-1673 VBN denotes shown
T4898 1674-1678 RB denotes here
T4899 1678-1680 , denotes ,
T4900 1680-1683 DT denotes the
T4901 1684-1692 NNS denotes vesicles
T4902 1700-1702 TO denotes to
T4903 1703-1706 VB denotes bud
T4904 1707-1711 IN denotes from
T4905 1712-1715 DT denotes the
T4906 1722-1730 NNS denotes segments
T4907 1716-1721 JJ denotes inner
T4908 1731-1741 PRP denotes themselves
T4909 1741-1742 . denotes .
T4910 1742-1920 sentence denotes In developing photoreceptors, an extraordinary growth process occurs whereby the outer segment is generated from the nascent connecting cilium (see [38] and references therein).
T4911 1743-1745 IN denotes In
T4912 1805-1811 VBZ denotes occurs
T4913 1746-1756 VBG denotes developing
T4914 1757-1771 NNS denotes photoreceptors
T4915 1771-1773 , denotes ,
T4916 1773-1775 DT denotes an
T4917 1797-1804 NN denotes process
T4918 1776-1789 JJ denotes extraordinary
T4919 1790-1796 NN denotes growth
T4920 1812-1819 WRB denotes whereby
T4921 1841-1850 VBN denotes generated
T4922 1820-1823 DT denotes the
T4923 1830-1837 NN denotes segment
T4924 1824-1829 JJ denotes outer
T4925 1838-1840 VBZ denotes is
T4926 1851-1855 IN denotes from
T4927 1856-1859 DT denotes the
T4928 1879-1885 NN denotes cilium
T4929 1860-1867 JJ denotes nascent
T4930 1868-1878 VBG denotes connecting
T4931 1886-1887 -LRB- denotes (
T4932 1887-1890 VB denotes see
T4933 1891-1892 -LRB- denotes [
T4934 1892-1894 CD denotes 38
T4935 1894-1895 -RRB- denotes ]
T4936 1896-1899 CC denotes and
T4937 1900-1910 NNS denotes references
T4938 1911-1918 RB denotes therein
T4939 1918-1919 -RRB- denotes )
T4940 1919-1920 . denotes .
T4941 1920-2124 sentence denotes Peripherin/RDS and ROM-1 proteins (localized in disc rims) and the opsin proteins (localized throughout the discs) have important roles in the structural integrity of mature outer segments (see [39,29]).
T4942 1921-1931 NN denotes Peripherin
T4943 1932-1935 NN denotes RDS
T4944 1931-1932 HYPH denotes /
T4945 1946-1954 NN denotes proteins
T4946 1936-1939 CC denotes and
T4947 1940-1943 NN denotes ROM
T4948 1943-1944 HYPH denotes -
T4949 1944-1945 CD denotes 1
T4950 2036-2040 VBP denotes have
T4951 1955-1956 -LRB- denotes (
T4952 1956-1965 VBN denotes localized
T4953 1966-1968 IN denotes in
T4954 1969-1973 NN denotes disc
T4955 1974-1978 NNS denotes rims
T4956 1978-1979 -RRB- denotes )
T4957 1980-1983 CC denotes and
T4958 1984-1987 DT denotes the
T4959 1994-2002 NN denotes proteins
T4960 1988-1993 NN denotes opsin
T4961 2003-2004 -LRB- denotes (
T4962 2004-2013 VBN denotes localized
T4963 2014-2024 IN denotes throughout
T4964 2025-2028 DT denotes the
T4965 2029-2034 NNS denotes discs
T4966 2034-2035 -RRB- denotes )
T4967 2041-2050 JJ denotes important
T4968 2051-2056 NNS denotes roles
T4969 2057-2059 IN denotes in
T4970 2060-2063 DT denotes the
T4971 2075-2084 NN denotes integrity
T4972 2064-2074 JJ denotes structural
T4973 2085-2087 IN denotes of
T4974 2088-2094 JJ denotes mature
T4975 2101-2109 NNS denotes segments
T4976 2095-2100 JJ denotes outer
T4977 2110-2111 -LRB- denotes (
T4978 2111-2114 VB denotes see
T4979 2115-2116 -LRB- denotes [
T4980 2116-2118 CD denotes 39
T4981 2119-2121 CD denotes 29
T4982 2118-2119 , denotes ,
T4983 2121-2122 -RRB- denotes ]
T4984 2122-2123 -RRB- denotes )
T4985 2123-2124 . denotes .
T4986 2124-2197 sentence denotes ROM-1-/- mice produce disorganized outer segments with large disks [40].
T4987 2125-2128 NN denotes ROM
T4988 2134-2138 NNS denotes mice
T4989 2128-2129 HYPH denotes -
T4990 2129-2130 CD denotes 1
T4991 2130-2131 SYM denotes -
T4992 2131-2132 HYPH denotes /
T4993 2132-2133 SYM denotes -
T4994 2139-2146 VBP denotes produce
T4995 2147-2159 VBN denotes disorganized
T4996 2166-2174 NNS denotes segments
T4997 2160-2165 JJ denotes outer
T4998 2175-2179 IN denotes with
T4999 2180-2185 JJ denotes large
T5000 2186-2191 NNS denotes disks
T5001 2192-2193 -LRB- denotes [
T5002 2193-2195 CD denotes 40
T5003 2195-2196 -RRB- denotes ]
T5004 2196-2197 . denotes .
T5005 2197-2401 sentence denotes Crx, by virtue of being a transcription factor, presumably controls genes that are responsible for the building and perhaps maintenance of the outer segment structure, including rhodopsin and peripherin.
T5006 2198-2201 NN denotes Crx
T5007 2257-2265 VBZ denotes controls
T5008 2201-2203 , denotes ,
T5009 2203-2205 IN denotes by
T5010 2206-2212 NN denotes virtue
T5011 2213-2215 IN denotes of
T5012 2216-2221 VBG denotes being
T5013 2222-2223 DT denotes a
T5014 2238-2244 NN denotes factor
T5015 2224-2237 NN denotes transcription
T5016 2244-2246 , denotes ,
T5017 2246-2256 RB denotes presumably
T5018 2266-2271 NNS denotes genes
T5019 2272-2276 WDT denotes that
T5020 2277-2280 VBP denotes are
T5021 2281-2292 JJ denotes responsible
T5022 2293-2296 IN denotes for
T5023 2297-2300 DT denotes the
T5024 2301-2309 NN denotes building
T5025 2310-2313 CC denotes and
T5026 2314-2321 RB denotes perhaps
T5027 2322-2333 NN denotes maintenance
T5028 2334-2336 IN denotes of
T5029 2337-2340 DT denotes the
T5030 2355-2364 NN denotes structure
T5031 2341-2346 JJ denotes outer
T5032 2347-2354 NN denotes segment
T5033 2364-2366 , denotes ,
T5034 2366-2375 VBG denotes including
T5035 2376-2385 NN denotes rhodopsin
T5036 2386-2389 CC denotes and
T5037 2390-2400 NN denotes peripherin
T5038 2400-2401 . denotes .
T5039 2401-2597 sentence denotes Using northern blots [34], microarrays [10], and serial analysis of gene expression (SAGE) [35], we have defined a large number of genes that are altered in their expression level in Crx-/- mice.
T5040 2402-2407 VBG denotes Using
T5041 2507-2514 VBN denotes defined
T5042 2408-2416 NNP denotes northern
T5043 2417-2422 NNS denotes blots
T5044 2423-2424 -LRB- denotes [
T5045 2424-2426 CD denotes 34
T5046 2426-2427 -RRB- denotes ]
T5047 2427-2429 , denotes ,
T5048 2429-2440 NNS denotes microarrays
T5049 2441-2442 -LRB- denotes [
T5050 2442-2444 CD denotes 10
T5051 2444-2445 -RRB- denotes ]
T5052 2445-2447 , denotes ,
T5053 2447-2450 CC denotes and
T5054 2451-2457 JJ denotes serial
T5055 2458-2466 NN denotes analysis
T5056 2467-2469 IN denotes of
T5057 2470-2474 NN denotes gene
T5058 2475-2485 NN denotes expression
T5059 2486-2487 -LRB- denotes (
T5060 2487-2491 NN denotes SAGE
T5061 2491-2492 -RRB- denotes )
T5062 2493-2494 -LRB- denotes [
T5063 2494-2496 CD denotes 35
T5064 2496-2497 -RRB- denotes ]
T5065 2497-2499 , denotes ,
T5066 2499-2501 PRP denotes we
T5067 2502-2506 VBP denotes have
T5068 2515-2516 DT denotes a
T5069 2523-2529 NN denotes number
T5070 2517-2522 JJ denotes large
T5071 2530-2532 IN denotes of
T5072 2533-2538 NNS denotes genes
T5073 2539-2543 WDT denotes that
T5074 2548-2555 VBN denotes altered
T5075 2544-2547 VBP denotes are
T5076 2556-2558 IN denotes in
T5077 2559-2564 PRP$ denotes their
T5078 2576-2581 NN denotes level
T5079 2565-2575 NN denotes expression
T5080 2582-2584 IN denotes in
T5081 2585-2588 NN denotes Crx
T5082 2592-2596 NNS denotes mice
T5083 2588-2589 SYM denotes -
T5084 2589-2590 HYPH denotes /
T5085 2590-2591 SYM denotes -
T5086 2596-2597 . denotes .
T5087 2597-2729 sentence denotes We found that rhodopsin expression was severely diminished in Crx-/- animals, and peripherin mRNA was reduced by approximately 30%.
T5088 2598-2600 PRP denotes We
T5089 2601-2606 VBD denotes found
T5090 2607-2611 IN denotes that
T5091 2646-2656 VBN denotes diminished
T5092 2612-2621 NN denotes rhodopsin
T5093 2622-2632 NN denotes expression
T5094 2633-2636 VBD denotes was
T5095 2637-2645 RB denotes severely
T5096 2657-2659 IN denotes in
T5097 2660-2663 NN denotes Crx
T5098 2667-2674 NNS denotes animals
T5099 2663-2664 SYM denotes -
T5100 2664-2665 HYPH denotes /
T5101 2665-2666 SYM denotes -
T5102 2674-2676 , denotes ,
T5103 2676-2679 CC denotes and
T5104 2680-2690 NN denotes peripherin
T5105 2691-2695 NN denotes mRNA
T5106 2700-2707 VBN denotes reduced
T5107 2696-2699 VBD denotes was
T5108 2708-2710 IN denotes by
T5109 2711-2724 RB denotes approximately
T5110 2725-2727 CD denotes 30
T5111 2727-2728 NN denotes %
T5112 2728-2729 . denotes .
T5113 2729-2898 sentence denotes Transgenic mice with variable levels of expression of wild type rhodopsin exhibit rod degeneration [41], indicating the importance of the level of rhodopsin expression.
T5114 2730-2740 JJ denotes Transgenic
T5115 2741-2745 NNS denotes mice
T5116 2804-2811 VBP denotes exhibit
T5117 2746-2750 IN denotes with
T5118 2751-2759 JJ denotes variable
T5119 2760-2766 NNS denotes levels
T5120 2767-2769 IN denotes of
T5121 2770-2780 NN denotes expression
T5122 2781-2783 IN denotes of
T5123 2784-2788 JJ denotes wild
T5124 2789-2793 NN denotes type
T5125 2794-2803 NN denotes rhodopsin
T5126 2812-2815 NN denotes rod
T5127 2816-2828 NN denotes degeneration
T5128 2829-2830 -LRB- denotes [
T5129 2830-2832 CD denotes 41
T5130 2832-2833 -RRB- denotes ]
T5131 2833-2835 , denotes ,
T5132 2835-2845 VBG denotes indicating
T5133 2846-2849 DT denotes the
T5134 2850-2860 NN denotes importance
T5135 2861-2863 IN denotes of
T5136 2864-2867 DT denotes the
T5137 2868-2873 NN denotes level
T5138 2874-2876 IN denotes of
T5139 2877-2886 NN denotes rhodopsin
T5140 2887-2897 NN denotes expression
T5141 2897-2898 . denotes .
T5142 2898-3008 sentence denotes In addition, the timing of rhodopsin expression may be very important, as indicated by studies in Drosophila.
T5143 2899-2901 IN denotes In
T5144 2951-2953 VB denotes be
T5145 2902-2910 NN denotes addition
T5146 2910-2912 , denotes ,
T5147 2912-2915 DT denotes the
T5148 2916-2922 NN denotes timing
T5149 2923-2925 IN denotes of
T5150 2926-2935 NN denotes rhodopsin
T5151 2936-2946 NN denotes expression
T5152 2947-2950 MD denotes may
T5153 2954-2958 RB denotes very
T5154 2959-2968 JJ denotes important
T5155 2968-2970 , denotes ,
T5156 2970-2972 IN denotes as
T5157 2973-2982 VBN denotes indicated
T5158 2983-2985 IN denotes by
T5159 2986-2993 NNS denotes studies
T5160 2994-2996 IN denotes in
T5161 2997-3007 NNP denotes Drosophila
T5162 3007-3008 . denotes .
T5163 3008-3079 sentence denotes In Drosophila, rhodopsin (ninaE) is expressed in photoreceptors R1–R6.
T5164 3009-3011 IN denotes In
T5165 3045-3054 VBN denotes expressed
T5166 3012-3022 NNP denotes Drosophila
T5167 3022-3024 , denotes ,
T5168 3024-3033 NN denotes rhodopsin
T5169 3034-3035 -LRB- denotes (
T5170 3035-3040 NN denotes ninaE
T5171 3040-3041 -RRB- denotes )
T5172 3042-3044 VBZ denotes is
T5173 3055-3057 IN denotes in
T5174 3058-3072 NNS denotes photoreceptors
T5175 3073-3075 NN denotes R1
T5176 3075-3076 SYM denotes –
T5177 3076-3078 NN denotes R6
T5178 3078-3079 . denotes .
T5179 3079-3273 sentence denotes In ninaE null mutants, the rhabdomere, a structure analogous to vertebrate outer segments, fails to develop in R1–R6 photoreceptors [42], reminiscent of the situation in rhodopsin-/- mice [29].
T5180 3080-3082 IN denotes In
T5181 3171-3176 VBZ denotes fails
T5182 3083-3088 NN denotes ninaE
T5183 3089-3093 JJ denotes null
T5184 3094-3101 NNS denotes mutants
T5185 3101-3103 , denotes ,
T5186 3103-3106 DT denotes the
T5187 3107-3117 NN denotes rhabdomere
T5188 3117-3119 , denotes ,
T5189 3119-3120 DT denotes a
T5190 3121-3130 NN denotes structure
T5191 3131-3140 JJ denotes analogous
T5192 3141-3143 IN denotes to
T5193 3144-3154 NN denotes vertebrate
T5194 3161-3169 NNS denotes segments
T5195 3155-3160 JJ denotes outer
T5196 3169-3171 , denotes ,
T5197 3177-3179 TO denotes to
T5198 3180-3187 VB denotes develop
T5199 3188-3190 IN denotes in
T5200 3191-3193 NN denotes R1
T5201 3197-3211 NNS denotes photoreceptors
T5202 3193-3194 SYM denotes –
T5203 3194-3196 NN denotes R6
T5204 3212-3213 -LRB- denotes [
T5205 3213-3215 CD denotes 42
T5206 3215-3216 -RRB- denotes ]
T5207 3216-3218 , denotes ,
T5208 3218-3229 JJ denotes reminiscent
T5209 3230-3232 IN denotes of
T5210 3233-3236 DT denotes the
T5211 3237-3246 NN denotes situation
T5212 3247-3249 IN denotes in
T5213 3250-3259 NN denotes rhodopsin
T5214 3263-3267 NNS denotes mice
T5215 3259-3260 SYM denotes -
T5216 3260-3261 HYPH denotes /
T5217 3261-3262 SYM denotes -
T5218 3268-3269 -LRB- denotes [
T5219 3269-3271 CD denotes 29
T5220 3271-3272 -RRB- denotes ]
T5221 3272-3273 . denotes .
T5222 3273-3411 sentence denotes An intriguing experiment by Kumar et al. [43] demonstrated a temporal requirement for rhodopsin expression during rhabdomere development.
T5223 3274-3276 DT denotes An
T5224 3288-3298 NN denotes experiment
T5225 3277-3287 JJ denotes intriguing
T5226 3320-3332 VBD denotes demonstrated
T5227 3299-3301 IN denotes by
T5228 3302-3307 NNP denotes Kumar
T5229 3308-3310 FW denotes et
T5230 3311-3314 FW denotes al.
T5231 3315-3316 -LRB- denotes [
T5232 3316-3318 CD denotes 43
T5233 3318-3319 -RRB- denotes ]
T5234 3333-3334 DT denotes a
T5235 3344-3355 NN denotes requirement
T5236 3335-3343 JJ denotes temporal
T5237 3356-3359 IN denotes for
T5238 3360-3369 NN denotes rhodopsin
T5239 3370-3380 NN denotes expression
T5240 3381-3387 IN denotes during
T5241 3388-3398 NN denotes rhabdomere
T5242 3399-3410 NN denotes development
T5243 3410-3411 . denotes .
T5244 3411-3557 sentence denotes In ninaE null flies, a ninaE transgene under the control of a heat shock promoter was subjected to various temperature shifts during development.
T5245 3412-3414 IN denotes In
T5246 3498-3507 VBN denotes subjected
T5247 3415-3420 NN denotes ninaE
T5248 3421-3425 JJ denotes null
T5249 3426-3431 NNS denotes flies
T5250 3431-3433 , denotes ,
T5251 3433-3434 DT denotes a
T5252 3441-3450 NN denotes transgene
T5253 3435-3440 NN denotes ninaE
T5254 3451-3456 IN denotes under
T5255 3457-3460 DT denotes the
T5256 3461-3468 NN denotes control
T5257 3469-3471 IN denotes of
T5258 3472-3473 DT denotes a
T5259 3485-3493 NN denotes promoter
T5260 3474-3478 NN denotes heat
T5261 3479-3484 NN denotes shock
T5262 3494-3497 VBD denotes was
T5263 3508-3510 IN denotes to
T5264 3511-3518 JJ denotes various
T5265 3531-3537 NNS denotes shifts
T5266 3519-3530 NN denotes temperature
T5267 3538-3544 IN denotes during
T5268 3545-3556 NN denotes development
T5269 3556-3557 . denotes .
T5270 3557-3735 sentence denotes Heat shock during the normal time of rhodopsin onset resulted in substantial and long-lasting rescue of photoreceptor structure and transient rescue of photoreceptor physiology.
T5271 3558-3562 NN denotes Heat
T5272 3563-3568 NN denotes shock
T5273 3611-3619 VBD denotes resulted
T5274 3569-3575 IN denotes during
T5275 3576-3579 DT denotes the
T5276 3587-3591 NN denotes time
T5277 3580-3586 JJ denotes normal
T5278 3592-3594 IN denotes of
T5279 3595-3604 NN denotes rhodopsin
T5280 3605-3610 NN denotes onset
T5281 3620-3622 IN denotes in
T5282 3623-3634 JJ denotes substantial
T5283 3652-3658 NN denotes rescue
T5284 3635-3638 CC denotes and
T5285 3639-3643 RB denotes long
T5286 3644-3651 VBG denotes lasting
T5287 3643-3644 HYPH denotes -
T5288 3659-3661 IN denotes of
T5289 3662-3675 NN denotes photoreceptor
T5290 3676-3685 NN denotes structure
T5291 3686-3689 CC denotes and
T5292 3690-3699 JJ denotes transient
T5293 3700-3706 NN denotes rescue
T5294 3707-3709 IN denotes of
T5295 3710-3723 NN denotes photoreceptor
T5296 3724-3734 NN denotes physiology
T5297 3734-3735 . denotes .
T5298 3735-3953 sentence denotes However, expression shortly before or after this critical period failed to rescue, suggesting that rhodopsin expression during a discrete window of time in development is essential for proper rhabdomere morphogenesis.
T5299 3736-3743 RB denotes However
T5300 3801-3807 VBD denotes failed
T5301 3743-3745 , denotes ,
T5302 3745-3755 NN denotes expression
T5303 3756-3763 RB denotes shortly
T5304 3764-3770 IN denotes before
T5305 3771-3773 CC denotes or
T5306 3774-3779 IN denotes after
T5307 3780-3784 DT denotes this
T5308 3794-3800 NN denotes period
T5309 3785-3793 JJ denotes critical
T5310 3808-3810 TO denotes to
T5311 3811-3817 VB denotes rescue
T5312 3817-3819 , denotes ,
T5313 3819-3829 VBG denotes suggesting
T5314 3830-3834 IN denotes that
T5315 3904-3906 VBZ denotes is
T5316 3835-3844 NN denotes rhodopsin
T5317 3845-3855 NN denotes expression
T5318 3856-3862 IN denotes during
T5319 3863-3864 DT denotes a
T5320 3874-3880 NN denotes window
T5321 3865-3873 JJ denotes discrete
T5322 3881-3883 IN denotes of
T5323 3884-3888 NN denotes time
T5324 3889-3891 IN denotes in
T5325 3892-3903 NN denotes development
T5326 3907-3916 JJ denotes essential
T5327 3917-3920 IN denotes for
T5328 3921-3927 JJ denotes proper
T5329 3939-3952 NN denotes morphogenesis
T5330 3928-3938 JJ denotes rhabdomere
T5331 3952-3953 . denotes .
T5332 3953-4114 sentence denotes This result is consistent with observations in the rat wherein rhodopsin onset occurs with strict timing in the developmental history of most rods in vivo [44].
T5333 3954-3958 DT denotes This
T5334 3959-3965 NN denotes result
T5335 3966-3968 VBZ denotes is
T5336 3969-3979 JJ denotes consistent
T5337 3980-3984 IN denotes with
T5338 3985-3997 NNS denotes observations
T5339 3998-4000 IN denotes in
T5340 4001-4004 DT denotes the
T5341 4005-4008 NN denotes rat
T5342 4009-4016 IN denotes wherein
T5343 4033-4039 VBZ denotes occurs
T5344 4017-4026 NN denotes rhodopsin
T5345 4027-4032 NN denotes onset
T5346 4040-4044 IN denotes with
T5347 4045-4051 JJ denotes strict
T5348 4052-4058 NN denotes timing
T5349 4059-4061 IN denotes in
T5350 4062-4065 DT denotes the
T5351 4080-4087 NN denotes history
T5352 4066-4079 JJ denotes developmental
T5353 4088-4090 IN denotes of
T5354 4091-4095 JJS denotes most
T5355 4096-4100 NNS denotes rods
T5356 4101-4103 FW denotes in
T5357 4104-4108 FW denotes vivo
T5358 4109-4110 -LRB- denotes [
T5359 4110-4112 CD denotes 44
T5360 4112-4113 -RRB- denotes ]
T5361 4113-4114 . denotes .
T5362 4114-4315 sentence denotes Thus, through its regulation of rhodopsin levels, or perhaps through control of the kinetics of the up-regulation of rhodopsin beginning at about P6, Crx may be regulating outer segment morphogenesis.
T5363 4115-4119 RB denotes Thus
T5364 4276-4286 VBG denotes regulating
T5365 4119-4121 , denotes ,
T5366 4121-4128 IN denotes through
T5367 4129-4132 PRP$ denotes its
T5368 4133-4143 NN denotes regulation
T5369 4144-4146 IN denotes of
T5370 4147-4156 NN denotes rhodopsin
T5371 4157-4163 NNS denotes levels
T5372 4163-4165 , denotes ,
T5373 4165-4167 CC denotes or
T5374 4168-4175 RB denotes perhaps
T5375 4176-4183 IN denotes through
T5376 4184-4191 NN denotes control
T5377 4192-4194 IN denotes of
T5378 4195-4198 DT denotes the
T5379 4199-4207 NN denotes kinetics
T5380 4208-4210 IN denotes of
T5381 4211-4214 DT denotes the
T5382 4218-4228 NN denotes regulation
T5383 4215-4217 JJ denotes up
T5384 4217-4218 HYPH denotes -
T5385 4229-4231 IN denotes of
T5386 4232-4241 NN denotes rhodopsin
T5387 4242-4251 VBG denotes beginning
T5388 4252-4254 IN denotes at
T5389 4255-4260 RB denotes about
T5390 4261-4263 NN denotes P6
T5391 4263-4265 , denotes ,
T5392 4265-4268 NN denotes Crx
T5393 4269-4272 MD denotes may
T5394 4273-4275 VB denotes be
T5395 4287-4292 JJ denotes outer
T5396 4293-4300 NN denotes segment
T5397 4301-4314 NN denotes morphogenesis
T5398 4314-4315 . denotes .
T5399 4315-4366 sentence denotes The similarty of the two cases may extend further.
T5400 4316-4319 DT denotes The
T5401 4320-4329 NN denotes similarty
T5402 4351-4357 VB denotes extend
T5403 4330-4332 IN denotes of
T5404 4333-4336 DT denotes the
T5405 4341-4346 NNS denotes cases
T5406 4337-4340 CD denotes two
T5407 4347-4350 MD denotes may
T5408 4358-4365 RB denotes further
T5409 4365-4366 . denotes .
T5410 4366-4498 sentence denotes At present, the closest Crx relative in Drosophila is Otd, the founding member of the class of homeobox genes to which Crx belongs.
T5411 4367-4369 IN denotes At
T5412 4418-4420 VBZ denotes is
T5413 4370-4377 JJ denotes present
T5414 4377-4379 , denotes ,
T5415 4379-4382 DT denotes the
T5416 4391-4394 NN denotes Crx
T5417 4383-4390 JJS denotes closest
T5418 4395-4403 JJ denotes relative
T5419 4404-4406 IN denotes in
T5420 4407-4417 NNP denotes Drosophila
T5421 4421-4424 NN denotes Otd
T5422 4424-4426 , denotes ,
T5423 4426-4429 DT denotes the
T5424 4439-4445 NN denotes member
T5425 4430-4438 JJ denotes founding
T5426 4446-4448 IN denotes of
T5427 4449-4452 DT denotes the
T5428 4453-4458 NN denotes class
T5429 4459-4461 IN denotes of
T5430 4462-4470 NN denotes homeobox
T5431 4471-4476 NNS denotes genes
T5432 4477-4479 IN denotes to
T5433 4490-4497 VBZ denotes belongs
T5434 4480-4485 WDT denotes which
T5435 4486-4489 NN denotes Crx
T5436 4497-4498 . denotes .
T5437 4498-4618 sentence denotes Interestingly, in one hypomorphic allele of Drosophila otd, otduvi, photoreceptor morphogenesis is also disrupted [45].
T5438 4499-4512 RB denotes Interestingly
T5439 4603-4612 VBN denotes disrupted
T5440 4512-4514 , denotes ,
T5441 4514-4516 IN denotes in
T5442 4517-4520 CD denotes one
T5443 4533-4539 NN denotes allele
T5444 4521-4532 JJ denotes hypomorphic
T5445 4540-4542 IN denotes of
T5446 4543-4553 NNP denotes Drosophila
T5447 4554-4557 NN denotes otd
T5448 4557-4559 , denotes ,
T5449 4559-4565 NN denotes otduvi
T5450 4565-4567 , denotes ,
T5451 4567-4580 NN denotes photoreceptor
T5452 4581-4594 NN denotes morphogenesis
T5453 4595-4597 VBZ denotes is
T5454 4598-4602 RB denotes also
T5455 4613-4614 -LRB- denotes [
T5456 4614-4616 CD denotes 45
T5457 4616-4617 -RRB- denotes ]
T5458 4617-4618 . denotes .
T5459 4618-4688 sentence denotes We found that there are many other genes that are dependent upon Crx.
T5460 4619-4621 PRP denotes We
T5461 4622-4627 VBD denotes found
T5462 4628-4632 IN denotes that
T5463 4639-4642 VBP denotes are
T5464 4633-4638 EX denotes there
T5465 4643-4647 JJ denotes many
T5466 4654-4659 NNS denotes genes
T5467 4648-4653 JJ denotes other
T5468 4660-4664 WDT denotes that
T5469 4665-4668 VBP denotes are
T5470 4669-4678 JJ denotes dependent
T5471 4679-4683 IN denotes upon
T5472 4684-4687 NN denotes Crx
T5473 4687-4688 . denotes .
T5474 4688-4881 sentence denotes Those that are expressed at a lower level in the Crx-/- retina, such as rhodopsin and peripherin, comprise many that are either enriched or specific to photoreceptors in their expression [35].
T5475 4689-4694 DT denotes Those
T5476 4787-4795 VBP denotes comprise
T5477 4695-4699 WDT denotes that
T5478 4704-4713 VBN denotes expressed
T5479 4700-4703 VBP denotes are
T5480 4714-4716 IN denotes at
T5481 4717-4718 DT denotes a
T5482 4725-4730 NN denotes level
T5483 4719-4724 JJR denotes lower
T5484 4731-4733 IN denotes in
T5485 4734-4737 DT denotes the
T5486 4745-4751 NN denotes retina
T5487 4738-4741 NN denotes Crx
T5488 4741-4742 SYM denotes -
T5489 4742-4743 HYPH denotes /
T5490 4743-4744 SYM denotes -
T5491 4751-4753 , denotes ,
T5492 4753-4757 JJ denotes such
T5493 4758-4760 IN denotes as
T5494 4761-4770 NN denotes rhodopsin
T5495 4771-4774 CC denotes and
T5496 4775-4785 NN denotes peripherin
T5497 4785-4787 , denotes ,
T5498 4796-4800 JJ denotes many
T5499 4801-4805 WDT denotes that
T5500 4806-4809 VBP denotes are
T5501 4810-4816 RB denotes either
T5502 4817-4825 VBN denotes enriched
T5503 4826-4828 CC denotes or
T5504 4829-4837 JJ denotes specific
T5505 4838-4840 IN denotes to
T5506 4841-4855 NNS denotes photoreceptors
T5507 4856-4858 IN denotes in
T5508 4859-4864 PRP$ denotes their
T5509 4865-4875 NN denotes expression
T5510 4876-4877 -LRB- denotes [
T5511 4877-4879 CD denotes 35
T5512 4879-4880 -RRB- denotes ]
T5513 4880-4881 . denotes .
T5514 4881-5097 sentence denotes They include enzymes that are important in lipid metabolism, protein folding and transport, as well as in other processes that one might envision would be important in building a structure such as the outer segment.
T5515 4882-4886 PRP denotes They
T5516 4887-4894 VBP denotes include
T5517 4895-4902 NNS denotes enzymes
T5518 4903-4907 WDT denotes that
T5519 4908-4911 VBP denotes are
T5520 4912-4921 JJ denotes important
T5521 4922-4924 IN denotes in
T5522 4925-4930 NN denotes lipid
T5523 4931-4941 NN denotes metabolism
T5524 4941-4943 , denotes ,
T5525 4943-4950 NN denotes protein
T5526 4951-4958 NN denotes folding
T5527 4959-4962 CC denotes and
T5528 4963-4972 NN denotes transport
T5529 4972-4974 , denotes ,
T5530 4974-4976 RB denotes as
T5531 4982-4984 IN denotes as
T5532 4977-4981 RB denotes well
T5533 4985-4987 IN denotes in
T5534 4988-4993 JJ denotes other
T5535 4994-5003 NNS denotes processes
T5536 5004-5008 WDT denotes that
T5537 5019-5027 VB denotes envision
T5538 5009-5012 PRP denotes one
T5539 5013-5018 MD denotes might
T5540 5028-5033 MD denotes would
T5541 5034-5036 VB denotes be
T5542 5037-5046 JJ denotes important
T5543 5047-5049 IN denotes in
T5544 5050-5058 VBG denotes building
T5545 5059-5060 DT denotes a
T5546 5061-5070 NN denotes structure
T5547 5071-5075 JJ denotes such
T5548 5076-5078 IN denotes as
T5549 5079-5082 DT denotes the
T5550 5089-5096 NN denotes segment
T5551 5083-5088 JJ denotes outer
T5552 5096-5097 . denotes .
T5553 5097-5302 sentence denotes In situ hybridization using probes from this collection of genes has revealed that some of them have their RNA localized to the inner segment, a finding typical for proteins targeted to the outer segment.
T5554 5098-5100 FW denotes In
T5555 5101-5105 FW denotes situ
T5556 5106-5119 NN denotes hybridization
T5557 5167-5175 VBN denotes revealed
T5558 5120-5125 VBG denotes using
T5559 5126-5132 NNS denotes probes
T5560 5133-5137 IN denotes from
T5561 5138-5142 DT denotes this
T5562 5143-5153 NN denotes collection
T5563 5154-5156 IN denotes of
T5564 5157-5162 NNS denotes genes
T5565 5163-5166 VBZ denotes has
T5566 5176-5180 IN denotes that
T5567 5194-5198 VBP denotes have
T5568 5181-5185 DT denotes some
T5569 5186-5188 IN denotes of
T5570 5189-5193 PRP denotes them
T5571 5199-5204 PRP$ denotes their
T5572 5205-5208 NN denotes RNA
T5573 5209-5218 VBN denotes localized
T5574 5219-5221 IN denotes to
T5575 5222-5225 DT denotes the
T5576 5232-5239 NN denotes segment
T5577 5226-5231 JJ denotes inner
T5578 5239-5241 , denotes ,
T5579 5241-5242 DT denotes a
T5580 5243-5250 NN denotes finding
T5581 5251-5258 JJ denotes typical
T5582 5259-5262 IN denotes for
T5583 5263-5271 NN denotes proteins
T5584 5272-5280 VBN denotes targeted
T5585 5281-5283 IN denotes to
T5586 5284-5287 DT denotes the
T5587 5294-5301 NN denotes segment
T5588 5288-5293 JJ denotes outer
T5589 5301-5302 . denotes .
T5590 5302-5402 sentence denotes Future analyses of the function of these genes might reveal their role in outer segment biogenesis.
T5591 5303-5309 JJ denotes Future
T5592 5310-5318 NNS denotes analyses
T5593 5356-5362 VB denotes reveal
T5594 5319-5321 IN denotes of
T5595 5322-5325 DT denotes the
T5596 5326-5334 NN denotes function
T5597 5335-5337 IN denotes of
T5598 5338-5343 DT denotes these
T5599 5344-5349 NNS denotes genes
T5600 5350-5355 MD denotes might
T5601 5363-5368 PRP$ denotes their
T5602 5369-5373 NN denotes role
T5603 5374-5376 IN denotes in
T5604 5377-5382 JJ denotes outer
T5605 5383-5390 NN denotes segment
T5606 5391-5401 NN denotes biogenesis
T5607 5401-5402 . denotes .
T5608 5402-5495 sentence denotes Finally, polarization of photoreceptors was found to be largely intact, as was ciliogenesis.
T5609 5403-5410 RB denotes Finally
T5610 5447-5452 VBN denotes found
T5611 5410-5412 , denotes ,
T5612 5412-5424 NN denotes polarization
T5613 5425-5427 IN denotes of
T5614 5428-5442 NNS denotes photoreceptors
T5615 5443-5446 VBD denotes was
T5616 5453-5455 TO denotes to
T5617 5456-5458 VB denotes be
T5618 5459-5466 RB denotes largely
T5619 5467-5473 JJ denotes intact
T5620 5473-5475 , denotes ,
T5621 5475-5477 IN denotes as
T5622 5478-5481 VBD denotes was
T5623 5482-5494 NN denotes ciliogenesis
T5624 5494-5495 . denotes .
T5625 5495-5606 sentence denotes Another LCA gene, CRB1, and a related gene CRB3, have been implicated in ciliogenesis in in vitro models [46].
T5626 5496-5503 DT denotes Another
T5627 5508-5512 NN denotes gene
T5628 5504-5507 NN denotes LCA
T5629 5555-5565 VBN denotes implicated
T5630 5512-5514 , denotes ,
T5631 5514-5518 NN denotes CRB1
T5632 5518-5520 , denotes ,
T5633 5520-5523 CC denotes and
T5634 5524-5525 DT denotes a
T5635 5534-5538 NN denotes gene
T5636 5526-5533 JJ denotes related
T5637 5539-5543 NN denotes CRB3
T5638 5543-5545 , denotes ,
T5639 5545-5549 VBP denotes have
T5640 5550-5554 VBN denotes been
T5641 5566-5568 IN denotes in
T5642 5569-5581 NN denotes ciliogenesis
T5643 5582-5584 IN denotes in
T5644 5585-5587 FW denotes in
T5645 5588-5593 FW denotes vitro
T5646 5594-5600 NNS denotes models
T5647 5601-5602 -LRB- denotes [
T5648 5602-5604 CD denotes 46
T5649 5604-5605 -RRB- denotes ]
T5650 5605-5606 . denotes .
T5651 5606-5705 sentence denotes The Drosophila homologue of CRB1, Crumbs, has been implicated in photoreceptor morphogenesis [47].
T5652 5607-5610 DT denotes The
T5653 5622-5631 NN denotes homologue
T5654 5611-5621 NNP denotes Drosophila
T5655 5658-5668 VBN denotes implicated
T5656 5632-5634 IN denotes of
T5657 5635-5639 NN denotes CRB1
T5658 5639-5641 , denotes ,
T5659 5641-5647 NNP denotes Crumbs
T5660 5647-5649 , denotes ,
T5661 5649-5652 VBZ denotes has
T5662 5653-5657 VBN denotes been
T5663 5669-5671 IN denotes in
T5664 5672-5685 NN denotes photoreceptor
T5665 5686-5699 NN denotes morphogenesis
T5666 5700-5701 -LRB- denotes [
T5667 5701-5703 CD denotes 47
T5668 5703-5704 -RRB- denotes ]
T5669 5704-5705 . denotes .
T5670 5705-5937 sentence denotes However, the spontaneously occurring mouse mutant in CRB1, the Rd8 mouse, develops shortened outer segments that subsequently degenerate [48], suggesting that photoreceptor polarization and synaptogenesis are intact in this mutant.
T5671 5706-5713 RB denotes However
T5672 5780-5788 VBZ denotes develops
T5673 5713-5715 , denotes ,
T5674 5715-5718 DT denotes the
T5675 5749-5755 NN denotes mutant
T5676 5719-5732 RB denotes spontaneously
T5677 5733-5742 VBG denotes occurring
T5678 5743-5748 NN denotes mouse
T5679 5756-5758 IN denotes in
T5680 5759-5763 NN denotes CRB1
T5681 5763-5765 , denotes ,
T5682 5765-5768 DT denotes the
T5683 5773-5778 NN denotes mouse
T5684 5769-5772 NN denotes Rd8
T5685 5778-5780 , denotes ,
T5686 5789-5798 VBN denotes shortened
T5687 5805-5813 NNS denotes segments
T5688 5799-5804 JJ denotes outer
T5689 5814-5818 WDT denotes that
T5690 5832-5842 VBP denotes degenerate
T5691 5819-5831 RB denotes subsequently
T5692 5843-5844 -LRB- denotes [
T5693 5844-5846 CD denotes 48
T5694 5846-5847 -RRB- denotes ]
T5695 5847-5849 , denotes ,
T5696 5849-5859 VBG denotes suggesting
T5697 5860-5864 IN denotes that
T5698 5911-5914 VBP denotes are
T5699 5865-5878 NN denotes photoreceptor
T5700 5879-5891 NN denotes polarization
T5701 5892-5895 CC denotes and
T5702 5896-5910 NN denotes synaptogenesis
T5703 5915-5921 JJ denotes intact
T5704 5922-5924 IN denotes in
T5705 5925-5929 DT denotes this
T5706 5930-5936 NN denotes mutant
T5707 5936-5937 . denotes .
T5708 5937-6077 sentence denotes While CRB1 and Crx have been both linked to LCA, further work is necessary to determine if their function is linked in retinal development.
T5709 5938-5943 IN denotes While
T5710 5972-5978 VBN denotes linked
T5711 5944-5948 NN denotes CRB1
T5712 5949-5952 CC denotes and
T5713 5953-5956 NN denotes Crx
T5714 5957-5961 VBP denotes have
T5715 5962-5966 VBN denotes been
T5716 5967-5971 RB denotes both
T5717 6000-6002 VBZ denotes is
T5718 5979-5981 IN denotes to
T5719 5982-5985 NN denotes LCA
T5720 5985-5987 , denotes ,
T5721 5987-5994 JJ denotes further
T5722 5995-5999 NN denotes work
T5723 6003-6012 JJ denotes necessary
T5724 6013-6015 TO denotes to
T5725 6016-6025 VB denotes determine
T5726 6026-6028 IN denotes if
T5727 6047-6053 VBN denotes linked
T5728 6029-6034 PRP$ denotes their
T5729 6035-6043 NN denotes function
T5730 6044-6046 VBZ denotes is
T5731 6054-6056 IN denotes in
T5732 6057-6064 JJ denotes retinal
T5733 6065-6076 NN denotes development
T5734 6076-6077 . denotes .
T6165 6079-6093 NN denotes Synaptogenesis
T6166 6097-6106 VBN denotes perturbed
T6167 6094-6096 VBZ denotes is
T6168 6107-6109 IN denotes in
T6169 6110-6113 NN denotes Crx
T6170 6117-6131 NNS denotes photoreceptors
T6171 6113-6114 SYM denotes -
T6172 6114-6115 HYPH denotes /
T6173 6115-6116 SYM denotes -
T6174 6131-6233 sentence denotes The Crx-/- mouse demonstrates the most severe abnormality of photoreceptor synapses reported to date.
T6175 6132-6135 DT denotes The
T6176 6143-6148 NN denotes mouse
T6177 6136-6139 NN denotes Crx
T6178 6139-6140 SYM denotes -
T6179 6140-6141 HYPH denotes /
T6180 6141-6142 SYM denotes -
T6181 6149-6161 VBZ denotes demonstrates
T6182 6162-6165 DT denotes the
T6183 6178-6189 NN denotes abnormality
T6184 6166-6170 RBS denotes most
T6185 6171-6177 JJ denotes severe
T6186 6190-6192 IN denotes of
T6187 6193-6206 NN denotes photoreceptor
T6188 6207-6215 NNS denotes synapses
T6189 6216-6224 VBN denotes reported
T6190 6225-6227 IN denotes to
T6191 6228-6232 NN denotes date
T6192 6232-6233 . denotes .
T6193 6233-6372 sentence denotes The peripherin-/- mouse develops a normal complement of photoreceptor terminals which then degenerate as the photoreceptors are lost [30].
T6194 6234-6237 DT denotes The
T6195 6252-6257 NN denotes mouse
T6196 6238-6248 NN denotes peripherin
T6197 6248-6249 SYM denotes -
T6198 6249-6250 HYPH denotes /
T6199 6250-6251 SYM denotes -
T6200 6258-6266 VBZ denotes develops
T6201 6267-6268 DT denotes a
T6202 6276-6286 NN denotes complement
T6203 6269-6275 JJ denotes normal
T6204 6287-6289 IN denotes of
T6205 6290-6303 NN denotes photoreceptor
T6206 6304-6313 NNS denotes terminals
T6207 6314-6319 WDT denotes which
T6208 6325-6335 VBP denotes degenerate
T6209 6320-6324 RB denotes then
T6210 6336-6338 IN denotes as
T6211 6362-6366 VBN denotes lost
T6212 6339-6342 DT denotes the
T6213 6343-6357 NNS denotes photoreceptors
T6214 6358-6361 VBP denotes are
T6215 6367-6368 -LRB- denotes [
T6216 6368-6370 CD denotes 30
T6217 6370-6371 -RRB- denotes ]
T6218 6371-6372 . denotes .
T6219 6372-6546 sentence denotes Also, similarly in rhodopsin (Rho) and cyclic nucleotide-gated channel, alpha-3 (CNGA3) double knockout mice (Rho-/-, CNGA3-/-), synapses are reported to form normally [49].
T6220 6373-6377 RB denotes Also
T6221 6515-6523 VBN denotes reported
T6222 6377-6379 , denotes ,
T6223 6379-6388 RB denotes similarly
T6224 6389-6391 IN denotes in
T6225 6392-6401 NN denotes rhodopsin
T6226 6402-6403 -LRB- denotes (
T6227 6403-6406 NN denotes Rho
T6228 6406-6407 -RRB- denotes )
T6229 6408-6411 CC denotes and
T6230 6412-6418 JJ denotes cyclic
T6231 6436-6443 NN denotes channel
T6232 6419-6429 NN denotes nucleotide
T6233 6430-6435 VBN denotes gated
T6234 6429-6430 HYPH denotes -
T6235 6445-6450 NN denotes alpha
T6236 6443-6445 , denotes ,
T6237 6477-6481 NNS denotes mice
T6238 6450-6451 HYPH denotes -
T6239 6451-6452 CD denotes 3
T6240 6453-6454 -LRB- denotes (
T6241 6454-6459 NN denotes CNGA3
T6242 6459-6460 -RRB- denotes )
T6243 6461-6467 JJ denotes double
T6244 6468-6476 NN denotes knockout
T6245 6482-6483 -LRB- denotes (
T6246 6483-6486 NN denotes Rho
T6247 6486-6487 SYM denotes -
T6248 6487-6488 HYPH denotes /
T6249 6488-6489 SYM denotes -
T6250 6489-6491 , denotes ,
T6251 6491-6496 NN denotes CNGA3
T6252 6496-6497 SYM denotes -
T6253 6497-6498 HYPH denotes /
T6254 6498-6499 SYM denotes -
T6255 6499-6500 -RRB- denotes )
T6256 6500-6502 , denotes ,
T6257 6502-6510 NNS denotes synapses
T6258 6511-6514 VBP denotes are
T6259 6524-6526 TO denotes to
T6260 6527-6531 VB denotes form
T6261 6532-6540 RB denotes normally
T6262 6541-6542 -LRB- denotes [
T6263 6542-6544 CD denotes 49
T6264 6544-6545 -RRB- denotes ]
T6265 6545-6546 . denotes .
T6266 6546-6664 sentence denotes These observations demonstrate that photoreceptor synaptogenesis can occur in the absence of outer segment formation.
T6267 6547-6552 DT denotes These
T6268 6553-6565 NNS denotes observations
T6269 6566-6577 VBP denotes demonstrate
T6270 6578-6582 IN denotes that
T6271 6616-6621 VB denotes occur
T6272 6583-6596 NN denotes photoreceptor
T6273 6597-6611 NN denotes synaptogenesis
T6274 6612-6615 MD denotes can
T6275 6622-6624 IN denotes in
T6276 6625-6628 DT denotes the
T6277 6629-6636 NN denotes absence
T6278 6637-6639 IN denotes of
T6279 6640-6645 JJ denotes outer
T6280 6646-6653 NN denotes segment
T6281 6654-6663 NN denotes formation
T6282 6663-6664 . denotes .
T6283 6664-6903 sentence denotes In keeping with this observation is the fact that some electroretinogram activity is present in peripherin-/- mice, suggesting that minimal phototransduction is present in these mice, enough to drive activity at the photoreceptor synapse.
T6284 6665-6667 IN denotes In
T6285 6698-6700 VBZ denotes is
T6286 6668-6675 VBG denotes keeping
T6287 6676-6680 IN denotes with
T6288 6681-6685 DT denotes this
T6289 6686-6697 NN denotes observation
T6290 6701-6704 DT denotes the
T6291 6705-6709 NN denotes fact
T6292 6710-6714 IN denotes that
T6293 6747-6749 VBZ denotes is
T6294 6715-6719 DT denotes some
T6295 6738-6746 NN denotes activity
T6296 6720-6737 NN denotes electroretinogram
T6297 6750-6757 JJ denotes present
T6298 6758-6760 IN denotes in
T6299 6761-6771 NN denotes peripherin
T6300 6775-6779 NNS denotes mice
T6301 6771-6772 SYM denotes -
T6302 6772-6773 HYPH denotes /
T6303 6773-6774 SYM denotes -
T6304 6779-6781 , denotes ,
T6305 6781-6791 VBG denotes suggesting
T6306 6792-6796 IN denotes that
T6307 6823-6825 VBZ denotes is
T6308 6797-6804 JJ denotes minimal
T6309 6805-6822 NN denotes phototransduction
T6310 6826-6833 JJ denotes present
T6311 6834-6836 IN denotes in
T6312 6837-6842 DT denotes these
T6313 6843-6847 NNS denotes mice
T6314 6847-6849 , denotes ,
T6315 6849-6855 RB denotes enough
T6316 6856-6858 TO denotes to
T6317 6859-6864 VB denotes drive
T6318 6865-6873 NN denotes activity
T6319 6874-6876 IN denotes at
T6320 6877-6880 DT denotes the
T6321 6895-6902 NN denotes synapse
T6322 6881-6894 NN denotes photoreceptor
T6323 6902-6903 . denotes .
T6324 6903-7200 sentence denotes In vitro studies wherein synapse elements are formed in the absence of proper outer segment development and, therefore, possible absence of light-dependent photoreceptor activity, have indicated the independence of phototransduction and synapse formation, at least for the initial stages [50,51].
T6325 6904-6906 FW denotes In
T6326 6907-6912 FW denotes vitro
T6327 6913-6920 NNS denotes studies
T6328 7089-7098 VBN denotes indicated
T6329 6921-6928 IN denotes wherein
T6330 6950-6956 VBN denotes formed
T6331 6929-6936 NN denotes synapse
T6332 6937-6945 NNS denotes elements
T6333 6946-6949 VBP denotes are
T6334 6957-6959 IN denotes in
T6335 6960-6963 DT denotes the
T6336 6964-6971 NN denotes absence
T6337 6972-6974 IN denotes of
T6338 6975-6981 JJ denotes proper
T6339 6996-7007 NN denotes development
T6340 6982-6987 JJ denotes outer
T6341 6988-6995 NN denotes segment
T6342 7008-7011 CC denotes and
T6343 7011-7013 , denotes ,
T6344 7013-7022 RB denotes therefore
T6345 7033-7040 NN denotes absence
T6346 7022-7024 , denotes ,
T6347 7024-7032 JJ denotes possible
T6348 7041-7043 IN denotes of
T6349 7044-7049 NN denotes light
T6350 7050-7059 JJ denotes dependent
T6351 7049-7050 HYPH denotes -
T6352 7074-7082 NN denotes activity
T6353 7060-7073 NN denotes photoreceptor
T6354 7082-7084 , denotes ,
T6355 7084-7088 VBP denotes have
T6356 7099-7102 DT denotes the
T6357 7103-7115 NN denotes independence
T6358 7116-7118 IN denotes of
T6359 7119-7136 NN denotes phototransduction
T6360 7137-7140 CC denotes and
T6361 7141-7148 NN denotes synapse
T6362 7149-7158 NN denotes formation
T6363 7158-7160 , denotes ,
T6364 7160-7162 RB denotes at
T6365 7163-7168 RBS denotes least
T6366 7169-7172 IN denotes for
T6367 7173-7176 DT denotes the
T6368 7185-7191 NNS denotes stages
T6369 7177-7184 JJ denotes initial
T6370 7192-7193 -LRB- denotes [
T6371 7196-7198 CD denotes 51
T6372 7193-7195 CD denotes 50
T6373 7195-7196 , denotes ,
T6374 7198-7199 -RRB- denotes ]
T6375 7199-7200 . denotes .
T6376 7200-7354 sentence denotes These data then suggest that the fact that the Crx-/- photoreceptors do not have proper synaptic endings is not due to a lack of outer segment formation.
T6377 7201-7206 DT denotes These
T6378 7207-7211 NNS denotes data
T6379 7217-7224 VBP denotes suggest
T6380 7212-7216 RB denotes then
T6381 7225-7229 IN denotes that
T6382 7306-7308 VBZ denotes is
T6383 7230-7233 DT denotes the
T6384 7234-7238 NN denotes fact
T6385 7239-7243 IN denotes that
T6386 7277-7281 VB denotes have
T6387 7244-7247 DT denotes the
T6388 7255-7269 NNS denotes photoreceptors
T6389 7248-7251 NN denotes Crx
T6390 7251-7252 SYM denotes -
T6391 7252-7253 HYPH denotes /
T6392 7253-7254 SYM denotes -
T6393 7270-7272 VBP denotes do
T6394 7273-7276 RB denotes not
T6395 7282-7288 JJ denotes proper
T6396 7298-7305 NNS denotes endings
T6397 7289-7297 JJ denotes synaptic
T6398 7309-7312 RB denotes not
T6399 7313-7316 IN denotes due
T6400 7317-7319 IN denotes to
T6401 7320-7321 DT denotes a
T6402 7322-7326 NN denotes lack
T6403 7327-7329 IN denotes of
T6404 7330-7335 JJ denotes outer
T6405 7336-7343 NN denotes segment
T6406 7344-7353 NN denotes formation
T6407 7353-7354 . denotes .
T6408 7354-7521 sentence denotes A more likely explanation is that Crx plays a role in photoreceptor synapse formation, perhaps by regulating directly, or indirectly, important genes in this process.
T6409 7355-7356 DT denotes A
T6410 7369-7380 NN denotes explanation
T6411 7357-7361 RBR denotes more
T6412 7362-7368 JJ denotes likely
T6413 7381-7383 VBZ denotes is
T6414 7384-7388 IN denotes that
T6415 7393-7398 VBZ denotes plays
T6416 7389-7392 NN denotes Crx
T6417 7399-7400 DT denotes a
T6418 7401-7405 NN denotes role
T6419 7406-7408 IN denotes in
T6420 7409-7422 NN denotes photoreceptor
T6421 7423-7430 NN denotes synapse
T6422 7431-7440 NN denotes formation
T6423 7440-7442 , denotes ,
T6424 7442-7449 RB denotes perhaps
T6425 7450-7452 IN denotes by
T6426 7453-7463 VBG denotes regulating
T6427 7464-7472 RB denotes directly
T6428 7472-7474 , denotes ,
T6429 7474-7476 CC denotes or
T6430 7477-7487 RB denotes indirectly
T6431 7487-7489 , denotes ,
T6432 7489-7498 JJ denotes important
T6433 7499-7504 NNS denotes genes
T6434 7505-7507 IN denotes in
T6435 7508-7512 DT denotes this
T6436 7513-7520 NN denotes process
T6437 7520-7521 . denotes .
T6438 7521-7769 sentence denotes Using immunohistochemistry, we examined the expression of common pre-synaptic terminal proteins, including KIF3a, SV2, and synaptophysin, and were unable to observe qualitative differences between Crx-/- and control tissue at P14 (data not shown).
T6439 7522-7527 VBG denotes Using
T6440 7553-7561 VBD denotes examined
T6441 7528-7548 NN denotes immunohistochemistry
T6442 7548-7550 , denotes ,
T6443 7550-7552 PRP denotes we
T6444 7562-7565 DT denotes the
T6445 7566-7576 NN denotes expression
T6446 7577-7579 IN denotes of
T6447 7580-7586 JJ denotes common
T6448 7609-7617 NN denotes proteins
T6449 7587-7599 JJ denotes pre-synaptic
T6450 7600-7608 JJ denotes terminal
T6451 7617-7619 , denotes ,
T6452 7619-7628 VBG denotes including
T6453 7629-7634 NN denotes KIF3a
T6454 7634-7636 , denotes ,
T6455 7636-7639 NN denotes SV2
T6456 7639-7641 , denotes ,
T6457 7641-7644 CC denotes and
T6458 7645-7658 NN denotes synaptophysin
T6459 7658-7660 , denotes ,
T6460 7660-7663 CC denotes and
T6461 7664-7668 VBD denotes were
T6462 7669-7675 JJ denotes unable
T6463 7676-7678 TO denotes to
T6464 7679-7686 VB denotes observe
T6465 7687-7698 JJ denotes qualitative
T6466 7699-7710 NNS denotes differences
T6467 7711-7718 IN denotes between
T6468 7719-7722 NN denotes Crx
T6469 7738-7744 NN denotes tissue
T6470 7722-7723 SYM denotes -
T6471 7723-7724 HYPH denotes /
T6472 7724-7725 SYM denotes -
T6473 7726-7729 CC denotes and
T6474 7730-7737 NN denotes control
T6475 7745-7747 IN denotes at
T6476 7748-7751 NN denotes P14
T6477 7752-7753 -LRB- denotes (
T6478 7762-7767 VBN denotes shown
T6479 7753-7757 NNS denotes data
T6480 7758-7761 RB denotes not
T6481 7767-7768 -RRB- denotes )
T6482 7768-7769 . denotes .
T6483 7769-7977 sentence denotes Examination of their RNA levels by SAGE showed no significant difference for all 3 genes, though very few tags were recovered from these genes and thus the analysis of RNA levels may not be significant [35].
T6484 7770-7781 NN denotes Examination
T6485 7810-7816 VBD denotes showed
T6486 7782-7784 IN denotes of
T6487 7785-7790 PRP$ denotes their
T6488 7795-7801 NNS denotes levels
T6489 7791-7794 NN denotes RNA
T6490 7802-7804 IN denotes by
T6491 7805-7809 NN denotes SAGE
T6492 7817-7819 DT denotes no
T6493 7832-7842 NN denotes difference
T6494 7820-7831 JJ denotes significant
T6495 7843-7846 IN denotes for
T6496 7847-7850 DT denotes all
T6497 7853-7858 NNS denotes genes
T6498 7851-7852 CD denotes 3
T6499 7858-7860 , denotes ,
T6500 7860-7866 IN denotes though
T6501 7886-7895 VBN denotes recovered
T6502 7867-7871 RB denotes very
T6503 7872-7875 JJ denotes few
T6504 7876-7880 NNS denotes tags
T6505 7881-7885 VBD denotes were
T6506 7896-7900 IN denotes from
T6507 7901-7906 DT denotes these
T6508 7907-7912 NNS denotes genes
T6509 7913-7916 CC denotes and
T6510 7917-7921 RB denotes thus
T6511 7957-7959 VB denotes be
T6512 7922-7925 DT denotes the
T6513 7926-7934 NN denotes analysis
T6514 7935-7937 IN denotes of
T6515 7938-7941 NN denotes RNA
T6516 7942-7948 NNS denotes levels
T6517 7949-7952 MD denotes may
T6518 7953-7956 RB denotes not
T6519 7960-7971 JJ denotes significant
T6520 7972-7973 -LRB- denotes [
T6521 7973-7975 CD denotes 35
T6522 7975-7976 -RRB- denotes ]
T6523 7976-7977 . denotes .
T6524 7977-8189 sentence denotes However, since other genes expressed in photoreceptors were significantly altered in their expression level in the Crx-/- mouse, there are many candidates that could be important for photoreceptor morphogenesis.
T6525 7978-7985 RB denotes However
T6526 8113-8116 VBP denotes are
T6527 7985-7987 , denotes ,
T6528 7987-7992 IN denotes since
T6529 8052-8059 VBN denotes altered
T6530 7993-7998 JJ denotes other
T6531 7999-8004 NNS denotes genes
T6532 8005-8014 VBN denotes expressed
T6533 8015-8017 IN denotes in
T6534 8018-8032 NNS denotes photoreceptors
T6535 8033-8037 VBD denotes were
T6536 8038-8051 RB denotes significantly
T6537 8060-8062 IN denotes in
T6538 8063-8068 PRP$ denotes their
T6539 8080-8085 NN denotes level
T6540 8069-8079 NN denotes expression
T6541 8086-8088 IN denotes in
T6542 8089-8092 DT denotes the
T6543 8100-8105 NN denotes mouse
T6544 8093-8096 NN denotes Crx
T6545 8096-8097 SYM denotes -
T6546 8097-8098 HYPH denotes /
T6547 8098-8099 SYM denotes -
T6548 8105-8107 , denotes ,
T6549 8107-8112 EX denotes there
T6550 8117-8121 JJ denotes many
T6551 8122-8132 NNS denotes candidates
T6552 8133-8137 WDT denotes that
T6553 8144-8146 VB denotes be
T6554 8138-8143 MD denotes could
T6555 8147-8156 JJ denotes important
T6556 8157-8160 IN denotes for
T6557 8161-8174 NN denotes photoreceptor
T6558 8175-8188 NN denotes morphogenesis
T6559 8188-8189 . denotes .
T6560 8189-8461 sentence denotes Tags from three genes from proteins expressed in photoreceptor terminals were found to be decreased in a statistically significant fashion, namely the HGF-regulated tyrosine kinase substrate, the CRIPT protein, and synaptotagmin 1 (Blackshaw and Cepko, unpublished data).
T6561 8190-8194 NNS denotes Tags
T6562 8268-8273 VBN denotes found
T6563 8195-8199 IN denotes from
T6564 8200-8205 CD denotes three
T6565 8206-8211 NNS denotes genes
T6566 8212-8216 IN denotes from
T6567 8217-8225 NN denotes proteins
T6568 8226-8235 VBN denotes expressed
T6569 8236-8238 IN denotes in
T6570 8239-8252 NN denotes photoreceptor
T6571 8253-8262 NNS denotes terminals
T6572 8263-8267 VBD denotes were
T6573 8274-8276 TO denotes to
T6574 8280-8289 VBN denotes decreased
T6575 8277-8279 VB denotes be
T6576 8290-8292 IN denotes in
T6577 8293-8294 DT denotes a
T6578 8321-8328 NN denotes fashion
T6579 8295-8308 RB denotes statistically
T6580 8309-8320 JJ denotes significant
T6581 8328-8330 , denotes ,
T6582 8330-8336 RB denotes namely
T6583 8371-8380 NN denotes substrate
T6584 8337-8340 DT denotes the
T6585 8341-8344 NN denotes HGF
T6586 8345-8354 VBN denotes regulated
T6587 8344-8345 HYPH denotes -
T6588 8355-8363 NN denotes tyrosine
T6589 8364-8370 NN denotes kinase
T6590 8380-8382 , denotes ,
T6591 8382-8385 DT denotes the
T6592 8392-8399 NN denotes protein
T6593 8386-8391 NN denotes CRIPT
T6594 8399-8401 , denotes ,
T6595 8401-8404 CC denotes and
T6596 8405-8418 NN denotes synaptotagmin
T6597 8419-8420 CD denotes 1
T6598 8421-8422 -LRB- denotes (
T6599 8422-8431 NNP denotes Blackshaw
T6600 8432-8435 CC denotes and
T6601 8436-8441 NNP denotes Cepko
T6602 8441-8443 , denotes ,
T6603 8443-8454 JJ denotes unpublished
T6604 8455-8459 NNS denotes data
T6605 8459-8460 -RRB- denotes )
T6606 8460-8461 . denotes .
T6607 8461-8668 sentence denotes An example of a gene that was increased in the Crx-/- retina is HRG4 (a homologue of the C. elegans Unc119 gene) (Blackshaw and Cepko, unpublished data) which encodes a component of the ribbon synapse [33].
T6608 8462-8464 DT denotes An
T6609 8465-8472 NN denotes example
T6610 8523-8525 VBZ denotes is
T6611 8473-8475 IN denotes of
T6612 8476-8477 DT denotes a
T6613 8478-8482 NN denotes gene
T6614 8483-8487 WDT denotes that
T6615 8492-8501 VBN denotes increased
T6616 8488-8491 VBD denotes was
T6617 8502-8504 IN denotes in
T6618 8505-8508 DT denotes the
T6619 8516-8522 NN denotes retina
T6620 8509-8512 NN denotes Crx
T6621 8512-8513 SYM denotes -
T6622 8513-8514 HYPH denotes /
T6623 8514-8515 SYM denotes -
T6624 8526-8530 NN denotes HRG4
T6625 8531-8532 -LRB- denotes (
T6626 8532-8533 DT denotes a
T6627 8534-8543 NN denotes homologue
T6628 8544-8546 IN denotes of
T6629 8547-8550 DT denotes the
T6630 8569-8573 NN denotes gene
T6631 8551-8553 NNP denotes C.
T6632 8554-8561 NNP denotes elegans
T6633 8562-8568 NN denotes Unc119
T6634 8573-8574 -RRB- denotes )
T6635 8575-8576 -LRB- denotes (
T6636 8576-8585 NNP denotes Blackshaw
T6637 8586-8589 CC denotes and
T6638 8590-8595 NNP denotes Cepko
T6639 8595-8597 , denotes ,
T6640 8597-8608 JJ denotes unpublished
T6641 8609-8613 NNS denotes data
T6642 8613-8614 -RRB- denotes )
T6643 8615-8620 WDT denotes which
T6644 8621-8628 VBZ denotes encodes
T6645 8629-8630 DT denotes a
T6646 8631-8640 NN denotes component
T6647 8641-8643 IN denotes of
T6648 8644-8647 DT denotes the
T6649 8655-8662 NN denotes synapse
T6650 8648-8654 NN denotes ribbon
T6651 8663-8664 -LRB- denotes [
T6652 8664-8666 CD denotes 33
T6653 8666-8667 -RRB- denotes ]
T6654 8667-8668 . denotes .
T6655 8668-8769 sentence denotes The fact that it is upregulated might indicate a response to the lack of proper terminal structures.
T6656 8669-8672 DT denotes The
T6657 8673-8677 NN denotes fact
T6658 8707-8715 VB denotes indicate
T6659 8678-8682 IN denotes that
T6660 8689-8700 VBN denotes upregulated
T6661 8683-8685 PRP denotes it
T6662 8686-8688 VBZ denotes is
T6663 8701-8706 MD denotes might
T6664 8716-8717 DT denotes a
T6665 8718-8726 NN denotes response
T6666 8727-8729 IN denotes to
T6667 8730-8733 DT denotes the
T6668 8734-8738 NN denotes lack
T6669 8739-8741 IN denotes of
T6670 8742-8748 JJ denotes proper
T6671 8758-8768 NNS denotes structures
T6672 8749-8757 JJ denotes terminal
T6673 8768-8769 . denotes .
T6674 8769-8965 sentence denotes Several other genes encoding putative cytoskeletal elements also were increased (e.g. microtubule associated protein 4) or decreased (e.g. cofilin 1) in the Crx-/- retina, with P values of <.005.
T6675 8770-8777 JJ denotes Several
T6676 8784-8789 NNS denotes genes
T6677 8778-8783 JJ denotes other
T6678 8840-8849 VBN denotes increased
T6679 8790-8798 VBG denotes encoding
T6680 8799-8807 JJ denotes putative
T6681 8821-8829 NNS denotes elements
T6682 8808-8820 JJ denotes cytoskeletal
T6683 8830-8834 RB denotes also
T6684 8835-8839 VBD denotes were
T6685 8850-8851 -LRB- denotes (
T6686 8879-8886 NN denotes protein
T6687 8851-8855 FW denotes e.g.
T6688 8856-8867 NN denotes microtubule
T6689 8868-8878 VBN denotes associated
T6690 8887-8888 CD denotes 4
T6691 8888-8889 -RRB- denotes )
T6692 8890-8892 CC denotes or
T6693 8893-8902 VBN denotes decreased
T6694 8903-8904 -LRB- denotes (
T6695 8909-8916 NN denotes cofilin
T6696 8904-8908 FW denotes e.g.
T6697 8917-8918 CD denotes 1
T6698 8918-8919 -RRB- denotes )
T6699 8920-8922 IN denotes in
T6700 8923-8926 DT denotes the
T6701 8934-8940 NN denotes retina
T6702 8927-8930 NN denotes Crx
T6703 8930-8931 SYM denotes -
T6704 8931-8932 HYPH denotes /
T6705 8932-8933 SYM denotes -
T6706 8940-8942 , denotes ,
T6707 8942-8946 IN denotes with
T6708 8947-8948 NN denotes P
T6709 8949-8955 NNS denotes values
T6710 8956-8958 IN denotes of
T6711 8959-8960 SYM denotes <
T6712 8960-8964 CD denotes .005
T6713 8964-8965 . denotes .
T6714 8965-9224 sentence denotes It is not known whether any of these genes are involved in building or regulating synaptic structures, but they are now genes that might lead to a better understanding of the construction and function of the relatively unique structure of the ribbon synapse.
T6715 8966-8968 PRP denotes It
T6716 8976-8981 VBN denotes known
T6717 8969-8971 VBZ denotes is
T6718 8972-8975 RB denotes not
T6719 8982-8989 IN denotes whether
T6720 9013-9021 VBN denotes involved
T6721 8990-8993 DT denotes any
T6722 8994-8996 IN denotes of
T6723 8997-9002 DT denotes these
T6724 9003-9008 NNS denotes genes
T6725 9009-9012 VBP denotes are
T6726 9022-9024 IN denotes in
T6727 9025-9033 VBG denotes building
T6728 9034-9036 CC denotes or
T6729 9037-9047 VBG denotes regulating
T6730 9048-9056 JJ denotes synaptic
T6731 9057-9067 NNS denotes structures
T6732 9067-9069 , denotes ,
T6733 9069-9072 CC denotes but
T6734 9073-9077 PRP denotes they
T6735 9078-9081 VBP denotes are
T6736 9082-9085 RB denotes now
T6737 9086-9091 NNS denotes genes
T6738 9092-9096 WDT denotes that
T6739 9103-9107 VB denotes lead
T6740 9097-9102 MD denotes might
T6741 9108-9110 IN denotes to
T6742 9111-9112 DT denotes a
T6743 9120-9133 NN denotes understanding
T6744 9113-9119 JJR denotes better
T6745 9134-9136 IN denotes of
T6746 9137-9140 DT denotes the
T6747 9141-9153 NN denotes construction
T6748 9154-9157 CC denotes and
T6749 9158-9166 NN denotes function
T6750 9167-9169 IN denotes of
T6751 9170-9173 DT denotes the
T6752 9192-9201 NN denotes structure
T6753 9174-9184 RB denotes relatively
T6754 9185-9191 JJ denotes unique
T6755 9202-9204 IN denotes of
T6756 9205-9208 DT denotes the
T6757 9216-9223 NN denotes synapse
T6758 9209-9215 NN denotes ribbon
T6759 9223-9224 . denotes .
T6760 9224-9370 sentence denotes Abnormal photoreceptor terminal formation was noted in a study that examined retinal development in the laminin beta2 chain-deficient mouse [52].
T6761 9225-9233 JJ denotes Abnormal
T6762 9257-9266 NN denotes formation
T6763 9234-9247 NN denotes photoreceptor
T6764 9248-9256 NN denotes terminal
T6765 9271-9276 VBN denotes noted
T6766 9267-9270 VBD denotes was
T6767 9277-9279 IN denotes in
T6768 9280-9281 DT denotes a
T6769 9282-9287 NN denotes study
T6770 9288-9292 WDT denotes that
T6771 9293-9301 VBD denotes examined
T6772 9302-9309 JJ denotes retinal
T6773 9310-9321 NN denotes development
T6774 9322-9324 IN denotes in
T6775 9325-9328 DT denotes the
T6776 9359-9364 NN denotes mouse
T6777 9329-9336 NN denotes laminin
T6778 9343-9348 NN denotes chain
T6779 9337-9342 NN denotes beta2
T6780 9349-9358 JJ denotes deficient
T6781 9348-9349 HYPH denotes -
T6782 9365-9366 -LRB- denotes [
T6783 9366-9368 CD denotes 52
T6784 9368-9369 -RRB- denotes ]
T6785 9369-9370 . denotes .
T6786 9370-9416 sentence denotes Several pathologies were noted in these mice.
T6787 9371-9378 JJ denotes Several
T6788 9379-9390 NNS denotes pathologies
T6789 9396-9401 VBN denotes noted
T6790 9391-9395 VBD denotes were
T6791 9402-9404 IN denotes in
T6792 9405-9410 DT denotes these
T6793 9411-9415 NNS denotes mice
T6794 9415-9416 . denotes .
T6795 9416-9609 sentence denotes First, laminin beta2 chain-deficient mice displayed abnormal outer segment elongation, but a more mild phenotype than that of the Crx-/- mice; the outer segments were reduced by 50% in length.
T6796 9417-9422 RB denotes First
T6797 9459-9468 VBD denotes displayed
T6798 9422-9424 , denotes ,
T6799 9424-9431 NN denotes laminin
T6800 9438-9443 NN denotes chain
T6801 9432-9437 NN denotes beta2
T6802 9444-9453 JJ denotes deficient
T6803 9443-9444 HYPH denotes -
T6804 9454-9458 NNS denotes mice
T6805 9584-9591 VBN denotes reduced
T6806 9469-9477 JJ denotes abnormal
T6807 9492-9502 NN denotes elongation
T6808 9478-9483 JJ denotes outer
T6809 9484-9491 NN denotes segment
T6810 9502-9504 , denotes ,
T6811 9504-9507 CC denotes but
T6812 9508-9509 DT denotes a
T6813 9520-9529 NN denotes phenotype
T6814 9510-9514 RBR denotes more
T6815 9515-9519 JJ denotes mild
T6816 9530-9534 IN denotes than
T6817 9535-9539 DT denotes that
T6818 9540-9542 IN denotes of
T6819 9543-9546 DT denotes the
T6820 9554-9558 NNS denotes mice
T6821 9547-9550 NN denotes Crx
T6822 9550-9551 SYM denotes -
T6823 9551-9552 HYPH denotes /
T6824 9552-9553 SYM denotes -
T6825 9558-9559 : denotes ;
T6826 9560-9563 DT denotes the
T6827 9570-9578 NNS denotes segments
T6828 9564-9569 JJ denotes outer
T6829 9579-9583 VBD denotes were
T6830 9592-9594 IN denotes by
T6831 9595-9597 CD denotes 50
T6832 9597-9598 NN denotes %
T6833 9599-9601 IN denotes in
T6834 9602-9608 NN denotes length
T6835 9608-9609 . denotes .
T6836 9609-9745 sentence denotes Also photoreceptor terminals were perturbed in laminin beta2 mutants, but again the phenotype was more subtle then that of Crx-/- mice.
T6837 9610-9614 RB denotes Also
T6838 9644-9653 VBN denotes perturbed
T6839 9615-9628 NN denotes photoreceptor
T6840 9629-9638 NNS denotes terminals
T6841 9639-9643 VBD denotes were
T6842 9654-9656 IN denotes in
T6843 9657-9664 NN denotes laminin
T6844 9665-9670 NN denotes beta2
T6845 9671-9678 NNS denotes mutants
T6846 9678-9680 , denotes ,
T6847 9680-9683 CC denotes but
T6848 9684-9689 RB denotes again
T6849 9704-9707 VBD denotes was
T6850 9690-9693 DT denotes the
T6851 9694-9703 NN denotes phenotype
T6852 9708-9712 RBR denotes more
T6853 9713-9719 JJ denotes subtle
T6854 9720-9724 IN denotes then
T6855 9725-9729 DT denotes that
T6856 9730-9732 IN denotes of
T6857 9733-9736 NN denotes Crx
T6858 9740-9744 NNS denotes mice
T6859 9736-9737 SYM denotes -
T6860 9737-9738 HYPH denotes /
T6861 9738-9739 SYM denotes -
T6862 9744-9745 . denotes .
T6863 9745-9949 sentence denotes The outer plexiform layer of the beta2-deficient retinas demonstrated only 7% normal invaginating synapses, while the remainder had various pathologies, including floating synaptic ribbons, as seen here.
T6864 9746-9749 DT denotes The
T6865 9766-9771 NN denotes layer
T6866 9750-9755 JJ denotes outer
T6867 9756-9765 NN denotes plexiform
T6868 9803-9815 VBD denotes demonstrated
T6869 9772-9774 IN denotes of
T6870 9775-9778 DT denotes the
T6871 9795-9802 NNS denotes retinas
T6872 9779-9784 NN denotes beta2
T6873 9785-9794 JJ denotes deficient
T6874 9784-9785 HYPH denotes -
T6875 9816-9820 RB denotes only
T6876 9821-9822 CD denotes 7
T6877 9822-9823 NN denotes %
T6878 9844-9852 NNS denotes synapses
T6879 9824-9830 JJ denotes normal
T6880 9831-9843 VBG denotes invaginating
T6881 9852-9854 , denotes ,
T6882 9854-9859 IN denotes while
T6883 9874-9877 VBD denotes had
T6884 9860-9863 DT denotes the
T6885 9864-9873 NN denotes remainder
T6886 9878-9885 JJ denotes various
T6887 9886-9897 NNS denotes pathologies
T6888 9897-9899 , denotes ,
T6889 9899-9908 VBG denotes including
T6890 9909-9917 VBG denotes floating
T6891 9927-9934 NNS denotes ribbons
T6892 9918-9926 JJ denotes synaptic
T6893 9934-9936 , denotes ,
T6894 9936-9938 IN denotes as
T6895 9939-9943 VBN denotes seen
T6896 9944-9948 RB denotes here
T6897 9948-9949 . denotes .
T6898 9949-10061 sentence denotes The mechanistic relationship of these two molecules, if any, in photoreceptor morphogenesis is unknown to date.
T6899 9950-9953 DT denotes The
T6900 9966-9978 NN denotes relationship
T6901 9954-9965 JJ denotes mechanistic
T6902 10042-10044 VBZ denotes is
T6903 9979-9981 IN denotes of
T6904 9982-9987 DT denotes these
T6905 9992-10001 NNS denotes molecules
T6906 9988-9991 CD denotes two
T6907 10001-10003 , denotes ,
T6908 10006-10009 DT denotes any
T6909 10003-10005 IN denotes if
T6910 10009-10011 , denotes ,
T6911 10011-10013 IN denotes in
T6912 10014-10027 NN denotes photoreceptor
T6913 10028-10041 NN denotes morphogenesis
T6914 10045-10052 JJ denotes unknown
T6915 10053-10055 IN denotes to
T6916 10056-10060 NN denotes date
T6917 10060-10061 . denotes .
T6918 10061-10259 sentence denotes The mRNA for laminin beta2 was not detected in the SAGE study of the relative RNA levels in Crx-/- and Crx+/+ and thus we cannot comment on whether the levels of RNA for laminin beta2 were altered.
T6919 10062-10065 DT denotes The
T6920 10066-10070 NN denotes mRNA
T6921 10097-10105 VBN denotes detected
T6922 10071-10074 IN denotes for
T6923 10075-10082 NN denotes laminin
T6924 10083-10088 NN denotes beta2
T6925 10089-10092 VBD denotes was
T6926 10093-10096 RB denotes not
T6927 10106-10108 IN denotes in
T6928 10109-10112 DT denotes the
T6929 10118-10123 NN denotes study
T6930 10113-10117 NN denotes SAGE
T6931 10124-10126 IN denotes of
T6932 10127-10130 DT denotes the
T6933 10144-10150 NNS denotes levels
T6934 10131-10139 JJ denotes relative
T6935 10140-10143 NN denotes RNA
T6936 10151-10153 IN denotes in
T6937 10154-10157 NN denotes Crx
T6938 10157-10158 SYM denotes -
T6939 10158-10159 HYPH denotes /
T6940 10159-10160 SYM denotes -
T6941 10161-10164 CC denotes and
T6942 10165-10168 NN denotes Crx
T6943 10168-10169 SYM denotes +
T6944 10169-10170 HYPH denotes /
T6945 10170-10171 SYM denotes +
T6946 10172-10175 CC denotes and
T6947 10176-10180 RB denotes thus
T6948 10191-10198 VB denotes comment
T6949 10181-10183 PRP denotes we
T6950 10184-10187 MD denotes can
T6951 10187-10190 RB denotes not
T6952 10199-10201 IN denotes on
T6953 10202-10209 IN denotes whether
T6954 10251-10258 VBN denotes altered
T6955 10210-10213 DT denotes the
T6956 10214-10220 NNS denotes levels
T6957 10221-10223 IN denotes of
T6958 10224-10227 NN denotes RNA
T6959 10228-10231 IN denotes for
T6960 10232-10239 NN denotes laminin
T6961 10240-10245 NN denotes beta2
T6962 10246-10250 VBD denotes were
T6963 10258-10259 . denotes .
T7157 10261-10264 NN denotes Crx
T7158 10268-10272 NNS denotes mice
T7159 10264-10265 SYM denotes -
T7160 10265-10266 HYPH denotes /
T7161 10266-10267 SYM denotes -
T7162 10273-10276 VBP denotes are
T7163 10277-10278 DT denotes a
T7164 10279-10284 NN denotes model
T7165 10285-10288 IN denotes for
T7166 10289-10292 NN denotes LCA
T7167 10292-10480 sentence denotes Crx has been implicated in three photoreceptor diseases that result in human blindness, cone-rod dystrophy2, Leber's congenital amaurosis, and retinitis pigmentosa (for review, see [53]).
T7168 10293-10296 NN denotes Crx
T7169 10306-10316 VBN denotes implicated
T7170 10297-10300 VBZ denotes has
T7171 10301-10305 VBN denotes been
T7172 10317-10319 IN denotes in
T7173 10320-10325 CD denotes three
T7174 10340-10348 NNS denotes diseases
T7175 10326-10339 NN denotes photoreceptor
T7176 10349-10353 WDT denotes that
T7177 10354-10360 VBP denotes result
T7178 10361-10363 IN denotes in
T7179 10364-10369 JJ denotes human
T7180 10370-10379 NN denotes blindness
T7181 10379-10381 , denotes ,
T7182 10381-10385 NN denotes cone
T7183 10386-10389 NN denotes rod
T7184 10385-10386 HYPH denotes -
T7185 10390-10400 NN denotes dystrophy2
T7186 10400-10402 , denotes ,
T7187 10402-10407 NNP denotes Leber
T7188 10421-10430 NN denotes amaurosis
T7189 10407-10409 POS denotes 's
T7190 10410-10420 JJ denotes congenital
T7191 10430-10432 , denotes ,
T7192 10432-10435 CC denotes and
T7193 10436-10445 NN denotes retinitis
T7194 10446-10456 NN denotes pigmentosa
T7195 10457-10458 -LRB- denotes (
T7196 10470-10473 VB denotes see
T7197 10458-10461 IN denotes for
T7198 10462-10468 NN denotes review
T7199 10468-10470 , denotes ,
T7200 10474-10475 -LRB- denotes [
T7201 10475-10477 CD denotes 53
T7202 10477-10478 -RRB- denotes ]
T7203 10478-10479 -RRB- denotes )
T7204 10479-10480 . denotes .
T7205 10480-10665 sentence denotes The cone-rod dystrophies (CRDs) are characterized by loss of cone-mediated vision in the first decade of life or later, with concomitant or subsequent loss of rod-mediated vision [54].
T7206 10481-10484 DT denotes The
T7207 10494-10505 NNS denotes dystrophies
T7208 10485-10489 NN denotes cone
T7209 10490-10493 NN denotes rod
T7210 10489-10490 HYPH denotes -
T7211 10517-10530 VBN denotes characterized
T7212 10506-10507 -LRB- denotes (
T7213 10507-10511 NNS denotes CRDs
T7214 10511-10512 -RRB- denotes )
T7215 10513-10516 VBP denotes are
T7216 10531-10533 IN denotes by
T7217 10534-10538 NN denotes loss
T7218 10539-10541 IN denotes of
T7219 10542-10546 NN denotes cone
T7220 10547-10555 VBN denotes mediated
T7221 10546-10547 HYPH denotes -
T7222 10556-10562 NN denotes vision
T7223 10563-10565 IN denotes in
T7224 10566-10569 DT denotes the
T7225 10576-10582 NN denotes decade
T7226 10570-10575 JJ denotes first
T7227 10583-10585 IN denotes of
T7228 10586-10590 NN denotes life
T7229 10591-10593 CC denotes or
T7230 10594-10599 RB denotes later
T7231 10601-10605 IN denotes with
T7232 10599-10601 , denotes ,
T7233 10606-10617 JJ denotes concomitant
T7234 10632-10636 NN denotes loss
T7235 10618-10620 CC denotes or
T7236 10621-10631 JJ denotes subsequent
T7237 10637-10639 IN denotes of
T7238 10640-10643 NN denotes rod
T7239 10644-10652 VBN denotes mediated
T7240 10643-10644 HYPH denotes -
T7241 10653-10659 NN denotes vision
T7242 10660-10661 -LRB- denotes [
T7243 10661-10663 CD denotes 54
T7244 10663-10664 -RRB- denotes ]
T7245 10664-10665 . denotes .
T7246 10665-10772 sentence denotes Conversely, RP is notable for initial loss of rod function, followed by loss of cone-mediated vision [55].
T7247 10666-10676 RB denotes Conversely
T7248 10681-10683 VBZ denotes is
T7249 10676-10678 , denotes ,
T7250 10678-10680 NN denotes RP
T7251 10684-10691 JJ denotes notable
T7252 10692-10695 IN denotes for
T7253 10696-10703 JJ denotes initial
T7254 10704-10708 NN denotes loss
T7255 10709-10711 IN denotes of
T7256 10712-10715 NN denotes rod
T7257 10716-10724 NN denotes function
T7258 10724-10726 , denotes ,
T7259 10726-10734 VBN denotes followed
T7260 10735-10737 IN denotes by
T7261 10738-10742 NN denotes loss
T7262 10743-10745 IN denotes of
T7263 10746-10750 NN denotes cone
T7264 10751-10759 VBN denotes mediated
T7265 10750-10751 HYPH denotes -
T7266 10760-10766 NN denotes vision
T7267 10767-10768 -LRB- denotes [
T7268 10768-10770 CD denotes 55
T7269 10770-10771 -RRB- denotes ]
T7270 10771-10772 . denotes .
T7271 10772-10962 sentence denotes The majority of known genes responsible for human genetic blindness, encode proteins expressed almost exclusively, or exclusively, in photoreceptors, particularly in the outer segment [35].
T7272 10773-10776 DT denotes The
T7273 10777-10785 NN denotes majority
T7274 10842-10848 VBP denotes encode
T7275 10786-10788 IN denotes of
T7276 10789-10794 JJ denotes known
T7277 10795-10800 NNS denotes genes
T7278 10801-10812 JJ denotes responsible
T7279 10813-10816 IN denotes for
T7280 10817-10822 JJ denotes human
T7281 10831-10840 NN denotes blindness
T7282 10823-10830 JJ denotes genetic
T7283 10840-10842 , denotes ,
T7284 10849-10857 NN denotes proteins
T7285 10858-10867 VBN denotes expressed
T7286 10868-10874 RB denotes almost
T7287 10875-10886 RB denotes exclusively
T7288 10904-10906 IN denotes in
T7289 10886-10888 , denotes ,
T7290 10888-10890 CC denotes or
T7291 10891-10902 RB denotes exclusively
T7292 10902-10904 , denotes ,
T7293 10907-10921 NNS denotes photoreceptors
T7294 10921-10923 , denotes ,
T7295 10923-10935 RB denotes particularly
T7296 10936-10938 IN denotes in
T7297 10939-10942 DT denotes the
T7298 10949-10956 NN denotes segment
T7299 10943-10948 JJ denotes outer
T7300 10957-10958 -LRB- denotes [
T7301 10958-10960 CD denotes 35
T7302 10960-10961 -RRB- denotes ]
T7303 10961-10962 . denotes .
T7304 10962-11048 sentence denotes Many of these proteins are required for phototransduction or outer segment structure.
T7305 10963-10967 JJ denotes Many
T7306 10990-10998 VBN denotes required
T7307 10968-10970 IN denotes of
T7308 10971-10976 DT denotes these
T7309 10977-10985 NN denotes proteins
T7310 10986-10989 VBP denotes are
T7311 10999-11002 IN denotes for
T7312 11003-11020 NN denotes phototransduction
T7313 11021-11023 CC denotes or
T7314 11024-11029 JJ denotes outer
T7315 11030-11037 NN denotes segment
T7316 11038-11047 NN denotes structure
T7317 11047-11048 . denotes .
T7318 11048-11182 sentence denotes The mechanisms whereby mutations in rod-specific genes, such as rhodopsin, lead eventually to cone degeneration in RP remain obscure.
T7319 11049-11052 DT denotes The
T7320 11053-11063 NNS denotes mechanisms
T7321 11167-11173 VBP denotes remain
T7322 11064-11071 WRB denotes whereby
T7323 11124-11128 VBP denotes lead
T7324 11072-11081 NNS denotes mutations
T7325 11082-11084 IN denotes in
T7326 11085-11088 NN denotes rod
T7327 11089-11097 JJ denotes specific
T7328 11088-11089 HYPH denotes -
T7329 11098-11103 NNS denotes genes
T7330 11103-11105 , denotes ,
T7331 11105-11109 JJ denotes such
T7332 11110-11112 IN denotes as
T7333 11113-11122 NN denotes rhodopsin
T7334 11122-11124 , denotes ,
T7335 11129-11139 RB denotes eventually
T7336 11140-11142 IN denotes to
T7337 11143-11147 NN denotes cone
T7338 11148-11160 NN denotes degeneration
T7339 11161-11163 IN denotes in
T7340 11164-11166 NN denotes RP
T7341 11174-11181 JJ denotes obscure
T7342 11181-11182 . denotes .
T7343 11182-11321 sentence denotes Mutations in Crx were the first, and still one of a very few examples of a transcription factor mutation leading to photoreceptor disease.
T7344 11183-11192 NNS denotes Mutations
T7345 11200-11204 VBD denotes were
T7346 11193-11195 IN denotes in
T7347 11196-11199 NN denotes Crx
T7348 11205-11208 DT denotes the
T7349 11209-11214 JJ denotes first
T7350 11214-11216 , denotes ,
T7351 11216-11219 CC denotes and
T7352 11220-11225 RB denotes still
T7353 11226-11229 CD denotes one
T7354 11244-11252 NNS denotes examples
T7355 11230-11232 IN denotes of
T7356 11233-11234 DT denotes a
T7357 11240-11243 JJ denotes few
T7358 11235-11239 RB denotes very
T7359 11253-11255 IN denotes of
T7360 11256-11257 DT denotes a
T7361 11279-11287 NN denotes mutation
T7362 11258-11271 NN denotes transcription
T7363 11272-11278 NN denotes factor
T7364 11288-11295 VBG denotes leading
T7365 11296-11298 IN denotes to
T7366 11299-11312 NN denotes photoreceptor
T7367 11313-11320 NN denotes disease
T7368 11320-11321 . denotes .
T7369 11321-11468 sentence denotes LCA is a disease in which there is little or no photoreceptor function in infancy; thereby, likely developmental in etiology ([17,56] for review).
T7370 11322-11325 NN denotes LCA
T7371 11326-11328 VBZ denotes is
T7372 11329-11330 DT denotes a
T7373 11331-11338 NN denotes disease
T7374 11339-11341 IN denotes in
T7375 11354-11356 VBZ denotes is
T7376 11342-11347 WDT denotes which
T7377 11348-11353 EX denotes there
T7378 11357-11363 JJ denotes little
T7379 11384-11392 NN denotes function
T7380 11364-11366 CC denotes or
T7381 11367-11369 DT denotes no
T7382 11370-11383 NN denotes photoreceptor
T7383 11393-11395 IN denotes in
T7384 11396-11403 NN denotes infancy
T7385 11403-11404 : denotes ;
T7386 11405-11412 RB denotes thereby
T7387 11421-11434 JJ denotes developmental
T7388 11412-11414 , denotes ,
T7389 11414-11420 RB denotes likely
T7390 11435-11437 IN denotes in
T7391 11438-11446 NN denotes etiology
T7392 11447-11448 -LRB- denotes (
T7393 11452-11454 CD denotes 56
T7394 11448-11449 -LRB- denotes [
T7395 11449-11451 CD denotes 17
T7396 11451-11452 , denotes ,
T7397 11454-11455 -RRB- denotes ]
T7398 11456-11459 IN denotes for
T7399 11460-11466 NN denotes review
T7400 11466-11467 -RRB- denotes )
T7401 11467-11468 . denotes .
T7402 11468-11631 sentence denotes The Crx-/- mouse may be an excellent model for studying the pathology of this disorder, particularly the subtype of the disorder where Crx mutations are involved.
T7403 11469-11472 DT denotes The
T7404 11480-11485 NN denotes mouse
T7405 11473-11476 NN denotes Crx
T7406 11476-11477 SYM denotes -
T7407 11477-11478 HYPH denotes /
T7408 11478-11479 SYM denotes -
T7409 11490-11492 VB denotes be
T7410 11486-11489 MD denotes may
T7411 11493-11495 DT denotes an
T7412 11506-11511 NN denotes model
T7413 11496-11505 JJ denotes excellent
T7414 11512-11515 IN denotes for
T7415 11516-11524 VBG denotes studying
T7416 11525-11528 DT denotes the
T7417 11529-11538 NN denotes pathology
T7418 11539-11541 IN denotes of
T7419 11542-11546 DT denotes this
T7420 11547-11555 NN denotes disorder
T7421 11555-11557 , denotes ,
T7422 11557-11569 RB denotes particularly
T7423 11574-11581 NN denotes subtype
T7424 11570-11573 DT denotes the
T7425 11582-11584 IN denotes of
T7426 11585-11588 DT denotes the
T7427 11589-11597 NN denotes disorder
T7428 11598-11603 WRB denotes where
T7429 11622-11630 VBN denotes involved
T7430 11604-11607 NN denotes Crx
T7431 11608-11617 NNS denotes mutations
T7432 11618-11621 VBP denotes are
T7433 11630-11631 . denotes .
T7434 11631-11798 sentence denotes The vast majority of histopathological studies of LCA in human tissue have been derived from adult patients with LCA where secondary changes are likely to be present.
T7435 11632-11635 DT denotes The
T7436 11641-11649 NN denotes majority
T7437 11636-11640 JJ denotes vast
T7438 11712-11719 VBN denotes derived
T7439 11650-11652 IN denotes of
T7440 11653-11670 JJ denotes histopathological
T7441 11671-11678 NNS denotes studies
T7442 11679-11681 IN denotes of
T7443 11682-11685 NN denotes LCA
T7444 11686-11688 IN denotes in
T7445 11689-11694 JJ denotes human
T7446 11695-11701 NN denotes tissue
T7447 11702-11706 VBP denotes have
T7448 11707-11711 VBN denotes been
T7449 11720-11724 IN denotes from
T7450 11725-11730 JJ denotes adult
T7451 11731-11739 NNS denotes patients
T7452 11740-11744 IN denotes with
T7453 11745-11748 NN denotes LCA
T7454 11749-11754 WRB denotes where
T7455 11773-11776 VBP denotes are
T7456 11755-11764 JJ denotes secondary
T7457 11765-11772 NNS denotes changes
T7458 11777-11783 JJ denotes likely
T7459 11784-11786 TO denotes to
T7460 11787-11789 VB denotes be
T7461 11790-11797 JJ denotes present
T7462 11797-11798 . denotes .
T7463 11798-11942 sentence denotes Indeed in animal models of LCA, secondary reactive and/or degenerative changes occur early after the abnormal formation of retinal tissue [57].
T7464 11799-11805 RB denotes Indeed
T7465 11878-11883 VBP denotes occur
T7466 11806-11808 IN denotes in
T7467 11809-11815 NN denotes animal
T7468 11816-11822 NNS denotes models
T7469 11823-11825 IN denotes of
T7470 11826-11829 NN denotes LCA
T7471 11829-11831 , denotes ,
T7472 11831-11840 JJ denotes secondary
T7473 11870-11877 NNS denotes changes
T7474 11841-11849 JJ denotes reactive
T7475 11850-11853 CC denotes and
T7476 11853-11854 HYPH denotes /
T7477 11854-11856 CC denotes or
T7478 11857-11869 JJ denotes degenerative
T7479 11884-11889 RB denotes early
T7480 11890-11895 IN denotes after
T7481 11896-11899 DT denotes the
T7482 11909-11918 NN denotes formation
T7483 11900-11908 JJ denotes abnormal
T7484 11919-11921 IN denotes of
T7485 11922-11929 JJ denotes retinal
T7486 11930-11936 NN denotes tissue
T7487 11937-11938 -LRB- denotes [
T7488 11938-11940 CD denotes 57
T7489 11940-11941 -RRB- denotes ]
T7490 11941-11942 . denotes .
T7491 11942-12103 sentence denotes The only study in human tissue derived from a human 33-week retina with proposed RPE65 mutations was reported to have abnormal retinae at this early stage [24].
T7492 11943-11946 DT denotes The
T7493 11952-11957 NN denotes study
T7494 11947-11951 JJ denotes only
T7495 12044-12052 VBN denotes reported
T7496 11958-11960 IN denotes in
T7497 11961-11966 JJ denotes human
T7498 11967-11973 NN denotes tissue
T7499 11974-11981 VBN denotes derived
T7500 11982-11986 IN denotes from
T7501 11987-11988 DT denotes a
T7502 12003-12009 NN denotes retina
T7503 11989-11994 JJ denotes human
T7504 11995-11997 CD denotes 33
T7505 11998-12002 NN denotes week
T7506 11997-11998 HYPH denotes -
T7507 12010-12014 IN denotes with
T7508 12015-12023 VBN denotes proposed
T7509 12030-12039 NNS denotes mutations
T7510 12024-12029 NN denotes RPE65
T7511 12040-12043 VBD denotes was
T7512 12053-12055 TO denotes to
T7513 12056-12060 VB denotes have
T7514 12061-12069 JJ denotes abnormal
T7515 12070-12077 NNS denotes retinae
T7516 12078-12080 IN denotes at
T7517 12081-12085 DT denotes this
T7518 12092-12097 NN denotes stage
T7519 12086-12091 JJ denotes early
T7520 12098-12099 -LRB- denotes [
T7521 12099-12101 CD denotes 24
T7522 12101-12102 -RRB- denotes ]
T7523 12102-12103 . denotes .
T7524 12103-12182 sentence denotes These authors report cell loss, including thinning of the photoreceptor layer.
T7525 12104-12109 DT denotes These
T7526 12110-12117 NNS denotes authors
T7527 12118-12124 VBP denotes report
T7528 12125-12129 NN denotes cell
T7529 12130-12134 NN denotes loss
T7530 12134-12136 , denotes ,
T7531 12136-12145 VBG denotes including
T7532 12146-12154 NN denotes thinning
T7533 12155-12157 IN denotes of
T7534 12158-12161 DT denotes the
T7535 12176-12181 NN denotes layer
T7536 12162-12175 NN denotes photoreceptor
T7537 12181-12182 . denotes .
T7538 12182-12400 sentence denotes In addition, they claim in the text to have seen aberrant synaptic and inner retinal organization, although their examination of photoreceptor synapses unfortunately are not presented in the data section of the paper.
T7539 12183-12185 IN denotes In
T7540 12201-12206 VBP denotes claim
T7541 12186-12194 NN denotes addition
T7542 12194-12196 , denotes ,
T7543 12196-12200 PRP denotes they
T7544 12207-12209 IN denotes in
T7545 12210-12213 DT denotes the
T7546 12214-12218 NN denotes text
T7547 12219-12221 TO denotes to
T7548 12227-12231 VBN denotes seen
T7549 12222-12226 VB denotes have
T7550 12232-12240 JJ denotes aberrant
T7551 12268-12280 NN denotes organization
T7552 12241-12249 JJ denotes synaptic
T7553 12250-12253 CC denotes and
T7554 12254-12259 JJ denotes inner
T7555 12260-12267 JJ denotes retinal
T7556 12280-12282 , denotes ,
T7557 12282-12290 IN denotes although
T7558 12357-12366 VBN denotes presented
T7559 12291-12296 PRP$ denotes their
T7560 12297-12308 NN denotes examination
T7561 12309-12311 IN denotes of
T7562 12312-12325 NN denotes photoreceptor
T7563 12326-12334 NNS denotes synapses
T7564 12335-12348 RB denotes unfortunately
T7565 12349-12352 VBP denotes are
T7566 12353-12356 RB denotes not
T7567 12367-12369 IN denotes in
T7568 12370-12373 DT denotes the
T7569 12379-12386 NN denotes section
T7570 12374-12378 NNS denotes data
T7571 12387-12389 IN denotes of
T7572 12390-12393 DT denotes the
T7573 12394-12399 NN denotes paper
T7574 12399-12400 . denotes .
T7575 12400-12527 sentence denotes Given the scarcity of available human tissue, the characterization of the primary pathology of LCA will require animal models.
T7576 12401-12406 VBN denotes Given
T7577 12505-12512 VB denotes require
T7578 12407-12410 DT denotes the
T7579 12411-12419 NN denotes scarcity
T7580 12420-12422 IN denotes of
T7581 12423-12432 JJ denotes available
T7582 12439-12445 NN denotes tissue
T7583 12433-12438 JJ denotes human
T7584 12445-12447 , denotes ,
T7585 12447-12450 DT denotes the
T7586 12451-12467 NN denotes characterization
T7587 12468-12470 IN denotes of
T7588 12471-12474 DT denotes the
T7589 12483-12492 NN denotes pathology
T7590 12475-12482 JJ denotes primary
T7591 12493-12495 IN denotes of
T7592 12496-12499 NN denotes LCA
T7593 12500-12504 MD denotes will
T7594 12513-12519 NN denotes animal
T7595 12520-12526 NNS denotes models
T7596 12526-12527 . denotes .
T7597 12527-12702 sentence denotes In the current study, we present data that argue that, in addition to outer segment morphogenesis, synaptogenesis may also be critically impaired in at least a subset of LCA.
T7598 12528-12530 IN denotes In
T7599 12553-12560 VBP denotes present
T7600 12531-12534 DT denotes the
T7601 12543-12548 NN denotes study
T7602 12535-12542 JJ denotes current
T7603 12548-12550 , denotes ,
T7604 12550-12552 PRP denotes we
T7605 12561-12565 NNS denotes data
T7606 12566-12570 WDT denotes that
T7607 12571-12576 VBP denotes argue
T7608 12577-12581 IN denotes that
T7609 12651-12653 VB denotes be
T7610 12581-12583 , denotes ,
T7611 12583-12585 IN denotes in
T7612 12586-12594 NN denotes addition
T7613 12595-12597 IN denotes to
T7614 12598-12603 JJ denotes outer
T7615 12604-12611 NN denotes segment
T7616 12612-12625 NN denotes morphogenesis
T7617 12625-12627 , denotes ,
T7618 12627-12641 NN denotes synaptogenesis
T7619 12642-12645 MD denotes may
T7620 12646-12650 RB denotes also
T7621 12654-12664 RB denotes critically
T7622 12665-12673 JJ denotes impaired
T7623 12674-12676 IN denotes in
T7624 12677-12679 RB denotes at
T7625 12686-12687 DT denotes a
T7626 12680-12685 RBS denotes least
T7627 12688-12694 NN denotes subset
T7628 12695-12697 IN denotes of
T7629 12698-12701 NN denotes LCA
T7630 12701-12702 . denotes .
R2407 T4008 T4009 prep In,carried
R2408 T4010 T4011 det this,study
R2409 T4011 T4008 pobj study,In
R2410 T4012 T4009 punct ", ",carried
R2411 T4013 T4014 det an,analysis
R2412 T4014 T4009 nsubjpass analysis,carried
R2413 T4015 T4014 amod ultrastructural,analysis
R2414 T4016 T4014 prep of,analysis
R2415 T4017 T4018 nmod Crx,photoreceptors
R2416 T4018 T4016 pobj photoreceptors,of
R2417 T4019 T4017 punct -,Crx
R2418 T4020 T4017 punct /,Crx
R2419 T4021 T4017 punct -,Crx
R2420 T4022 T4009 auxpass was,carried
R2421 T4023 T4009 prt out,carried
R2422 T4024 T4009 punct .,carried
R2423 T4026 T4027 mark As,associated
R2424 T4027 T4032 advcl associated,broaden
R2425 T4028 T4029 compound Crx,mutations
R2426 T4029 T4027 nsubjpass mutations,associated
R2427 T4030 T4027 aux have,associated
R2428 T4031 T4027 auxpass been,associated
R2429 T4033 T4027 prep with,associated
R2430 T4034 T4035 poss Leber,amaurosis
R2431 T4035 T4033 pobj amaurosis,with
R2432 T4036 T4034 case 's,Leber
R2433 T4037 T4035 amod congenital,amaurosis
R2434 T4038 T4032 punct ", ",broaden
R2435 T4039 T4040 det the,findings
R2436 T4040 T4032 nsubj findings,broaden
R2437 T4041 T4040 prep in,findings
R2438 T4042 T4043 det this,study
R2439 T4043 T4041 pobj study,in
R2440 T4044 T4045 poss our,understanding
R2441 T4045 T4032 dobj understanding,broaden
R2442 T4046 T4045 prep of,understanding
R2443 T4047 T4048 det the,pathology
R2444 T4048 T4046 pobj pathology,of
R2445 T4049 T4048 prep of,pathology
R2446 T4050 T4051 det this,disease
R2447 T4051 T4049 pobj disease,of
R2448 T4052 T4032 punct .,broaden
R2449 T4054 T4055 nummod Two,pathologies
R2450 T4055 T4057 nsubjpass pathologies,characterized
R2451 T4056 T4055 amod prominent,pathologies
R2452 T4057 T4059 ccomp characterized,exhibited
R2453 T4058 T4057 auxpass were,characterized
R2454 T4060 T4057 prep in,characterized
R2455 T4061 T4062 det the,retina
R2456 T4062 T4060 pobj retina,in
R2457 T4063 T4062 nmod Crx,retina
R2458 T4064 T4063 punct -,Crx
R2459 T4065 T4063 punct /,Crx
R2460 T4066 T4063 punct -,Crx
R2461 T4067 T4059 punct : ,exhibited
R2462 T4068 T4069 punct (,1
R2463 T4069 T4070 meta 1,noted
R2464 T4070 T4059 ccomp noted,exhibited
R2465 T4071 T4069 punct ),1
R2466 T4072 T4073 det An,block
R2467 T4073 T4070 nsubjpass block,noted
R2468 T4074 T4073 amod absolute,block
R2469 T4075 T4073 prep in,block
R2470 T4076 T4077 amod outer,segment
R2471 T4077 T4078 compound segment,morphogenesis
R2472 T4078 T4075 pobj morphogenesis,in
R2473 T4079 T4070 auxpass was,noted
R2474 T4080 T4070 punct ", ",noted
R2475 T4081 T4070 prep with,noted
R2476 T4082 T4083 det the,block
R2477 T4083 T4084 nsubj block,occuring
R2478 T4084 T4081 pcomp occuring,with
R2479 T4085 T4084 prep at,occuring
R2480 T4086 T4087 det the,stage
R2481 T4087 T4085 pobj stage,at
R2482 T4088 T4087 compound elongation,stage
R2483 T4089 T4087 prep of,stage
R2484 T4090 T4091 amod outer,segment
R2485 T4091 T4092 compound segment,formation
R2486 T4092 T4089 pobj formation,of
R2487 T4093 T4059 punct ;,exhibited
R2488 T4094 T4095 punct (,2
R2489 T4095 T4059 meta 2,exhibited
R2490 T4096 T4095 punct ),2
R2491 T4097 T4098 nmod Crx,photoreceptors
R2492 T4098 T4059 nsubj photoreceptors,exhibited
R2493 T4099 T4097 punct -,Crx
R2494 T4100 T4097 punct /,Crx
R2495 T4101 T4097 punct -,Crx
R2496 T4102 T4103 det a,perturbation
R2497 T4103 T4059 dobj perturbation,exhibited
R2498 T4104 T4103 amod severe,perturbation
R2499 T4105 T4103 prep in,perturbation
R2500 T4106 T4107 compound synapse,formation
R2501 T4107 T4105 pobj formation,in
R2502 T4108 T4059 punct .,exhibited
R2503 T4110 T4111 nsubj This,represents
R2504 T4112 T4113 det the,report
R2505 T4113 T4111 dobj report,represents
R2506 T4114 T4113 amod first,report
R2507 T4115 T4113 prep of,report
R2508 T4116 T4117 det a,defect
R2509 T4117 T4115 pobj defect,of
R2510 T4118 T4117 compound synaptogenesis,defect
R2511 T4119 T4117 prep in,defect
R2512 T4120 T4121 det an,model
R2513 T4121 T4119 pobj model,in
R2514 T4122 T4121 compound animal,model
R2515 T4123 T4121 prep of,model
R2516 T4124 T4123 pobj LCA,of
R2517 T4125 T4111 punct .,represents
R2524 T4696 T4697 nmod Crx,photoreceptors
R2525 T4697 T4701 nsubj photoreceptors,complete
R2526 T4698 T4696 punct -,Crx
R2527 T4699 T4696 punct /,Crx
R2528 T4700 T4696 punct -,Crx
R2529 T4702 T4701 aux can,complete
R2530 T4703 T4701 neg not,complete
R2531 T4704 T4705 amod outer,segment
R2532 T4705 T4706 compound segment,morphogenesis
R2533 T4706 T4701 dobj morphogenesis,complete
R2534 T4708 T4709 nsubj Mutations,represent
R2535 T4710 T4708 prep in,Mutations
R2536 T4711 T4710 pobj Crx,in
R2537 T4712 T4709 dobj one,represent
R2538 T4713 T4712 prep of,one
R2539 T4714 T4715 det a,collection
R2540 T4715 T4713 pobj collection,of
R2541 T4716 T4715 prep of,collection
R2542 T4717 T4718 compound gene,mutations
R2543 T4718 T4716 pobj mutations,of
R2544 T4719 T4720 dep that,lead
R2545 T4720 T4718 relcl lead,mutations
R2546 T4721 T4720 prep to,lead
R2547 T4722 T4723 det an,defect
R2548 T4723 T4721 pobj defect,to
R2549 T4724 T4725 amod outer,segment
R2550 T4725 T4723 compound segment,defect
R2551 T4726 T4723 compound formation,defect
R2552 T4727 T4709 punct .,represent
R2553 T4729 T4730 amod Homozygous,mutations
R2554 T4730 T4732 nsubj mutations,lead
R2555 T4731 T4730 amod null,mutations
R2556 T4733 T4730 prep in,mutations
R2557 T4734 T4735 det the,gene
R2558 T4735 T4733 pobj gene,in
R2559 T4736 T4737 compound peripherin,RDS
R2560 T4737 T4735 compound RDS,gene
R2561 T4738 T4737 punct /,RDS
R2562 T4739 T4740 punct [,36
R2563 T4740 T4735 parataxis 36,gene
R2564 T4741 T4740 punct ],36
R2565 T4742 T4733 cc or,in
R2566 T4743 T4733 conj in,in
R2567 T4744 T4743 pobj rhodopsin,in
R2568 T4745 T4746 punct [,29
R2569 T4746 T4744 parataxis 29,rhodopsin
R2570 T4747 T4746 punct ],29
R2571 T4748 T4732 prep to,lead
R2572 T4749 T4750 det a,failure
R2573 T4750 T4748 pobj failure,to
R2574 T4751 T4750 prep of,failure
R2575 T4752 T4753 amod outer,segment
R2576 T4753 T4754 compound segment,formation
R2577 T4754 T4751 pobj formation,of
R2578 T4755 T4732 punct .,lead
R2579 T4757 T4758 det The,deficits
R2580 T4758 T4759 nsubjpass deficits,found
R2581 T4760 T4758 prep in,deficits
R2582 T4761 T4762 nmod peripherin,morphogenesis
R2583 T4762 T4760 pobj morphogenesis,in
R2584 T4763 T4761 punct -,peripherin
R2585 T4764 T4761 punct /,peripherin
R2586 T4765 T4761 punct -,peripherin
R2587 T4766 T4761 cc and,peripherin
R2588 T4767 T4761 conj Crx,peripherin
R2589 T4768 T4767 punct -,Crx
R2590 T4769 T4767 punct /,Crx
R2591 T4770 T4767 punct -,Crx
R2592 T4771 T4762 compound photoreceptor,morphogenesis
R2593 T4772 T4759 auxpass were,found
R2594 T4773 T4774 aux to,be
R2595 T4774 T4759 xcomp be,found
R2596 T4775 T4776 advmod very,similar
R2597 T4776 T4774 acomp similar,be
R2598 T4777 T4759 punct .,found
R2599 T4779 T4780 amod Vesicular,structures
R2600 T4780 T4781 nsubjpass structures,observed
R2601 T4782 T4780 prep in,structures
R2602 T4783 T4784 nmod Crx,photoreceptors
R2603 T4784 T4782 pobj photoreceptors,in
R2604 T4785 T4783 punct -,Crx
R2605 T4786 T4783 punct /,Crx
R2606 T4787 T4783 punct -,Crx
R2607 T4788 T4781 auxpass were,observed
R2608 T4789 T4790 dep that,were
R2609 T4790 T4781 ccomp were,observed
R2610 T4791 T4790 acomp similar,were
R2611 T4792 T4791 prep to,similar
R2612 T4793 T4792 pobj those,to
R2613 T4794 T4795 advmod previously,noted
R2614 T4795 T4793 acl noted,those
R2615 T4796 T4795 prep in,noted
R2616 T4797 T4798 det the,mouse
R2617 T4798 T4796 pobj mouse,in
R2618 T4799 T4800 nmod rds,peripherin
R2619 T4800 T4798 nmod peripherin,mouse
R2620 T4801 T4800 punct /,peripherin
R2621 T4802 T4800 punct -,peripherin
R2622 T4803 T4800 punct /,peripherin
R2623 T4804 T4800 punct -,peripherin
R2624 T4805 T4781 punct .,observed
R2625 T4807 T4808 nsubjpass It,proposed
R2626 T4809 T4808 auxpass was,proposed
R2627 T4810 T4808 advmod initially,proposed
R2628 T4811 T4812 mark that,were
R2629 T4812 T4808 ccomp were,proposed
R2630 T4813 T4814 det these,vesicles
R2631 T4814 T4812 nsubj vesicles,were
R2632 T4815 T4812 prep due,were
R2633 T4816 T4815 pcomp to,due
R2634 T4817 T4818 det the,breakdown
R2635 T4818 T4815 pobj breakdown,due
R2636 T4819 T4818 prep of,breakdown
R2637 T4820 T4821 amod outer,segment
R2638 T4821 T4822 compound segment,membranes
R2639 T4822 T4819 pobj membranes,of
R2640 T4823 T4824 dep that,recruited
R2641 T4824 T4822 relcl recruited,membranes
R2642 T4825 T4824 auxpass were,recruited
R2643 T4826 T4824 neg not,recruited
R2644 T4827 T4824 advmod properly,recruited
R2645 T4828 T4824 prep to,recruited
R2646 T4829 T4830 det the,segments
R2647 T4830 T4828 pobj segments,to
R2648 T4831 T4830 amod outer,segments
R2649 T4832 T4824 prep in,recruited
R2650 T4833 T4834 det the,absence
R2651 T4834 T4832 pobj absence,in
R2652 T4835 T4834 prep of,absence
R2653 T4836 T4835 pobj peripherin,of
R2654 T4837 T4812 punct ", ",were
R2655 T4838 T4812 cc or,were
R2656 T4839 T4812 conj were,were
R2657 T4840 T4839 prep from,were
R2658 T4841 T4842 det the,result
R2659 T4842 T4840 pobj result,from
R2660 T4843 T4842 prep of,result
R2661 T4844 T4845 det the,breakdown
R2662 T4845 T4843 pobj breakdown,of
R2663 T4846 T4845 prep of,breakdown
R2664 T4847 T4848 det the,microvilli
R2665 T4848 T4846 pobj microvilli,of
R2666 T4849 T4848 prep of,microvilli
R2667 T4850 T4851 compound Müller,cells
R2668 T4851 T4849 pobj cells,of
R2669 T4852 T4853 punct [,30
R2670 T4853 T4839 parataxis 30,were
R2671 T4854 T4853 punct ],30
R2672 T4855 T4808 punct .,proposed
R2673 T4857 T4858 amod Strong,support
R2674 T4858 T4859 nsubjpass support,provided
R2675 T4860 T4858 prep in,support
R2676 T4861 T4860 pobj favor,in
R2677 T4862 T4861 prep of,favor
R2678 T4863 T4864 det the,explanation
R2679 T4864 T4862 pobj explanation,of
R2680 T4865 T4864 amod former,explanation
R2681 T4866 T4859 auxpass was,provided
R2682 T4867 T4859 agent by,provided
R2683 T4868 T4867 pobj Nir,by
R2684 T4869 T4868 cc and,Nir
R2685 T4870 T4868 conj colleagues,Nir
R2686 T4871 T4872 dep who,demonstrated
R2687 T4872 T4868 relcl demonstrated,Nir
R2688 T4873 T4874 det the,presence
R2689 T4874 T4872 dobj presence,demonstrated
R2690 T4875 T4874 prep of,presence
R2691 T4876 T4877 compound rhodopsin,protein
R2692 T4877 T4875 pobj protein,of
R2693 T4878 T4874 prep in,presence
R2694 T4879 T4880 det these,vesicles
R2695 T4880 T4878 pobj vesicles,in
R2696 T4881 T4872 advcl using,demonstrated
R2697 T4882 T4883 compound immunoelectron,microscopy
R2698 T4883 T4881 dobj microscopy,using
R2699 T4884 T4881 prep against,using
R2700 T4885 T4886 det a,epitope
R2701 T4886 T4884 pobj epitope,against
R2702 T4887 T4886 compound rhodopsin,epitope
R2703 T4888 T4889 punct [,37
R2704 T4889 T4872 parataxis 37,demonstrated
R2705 T4890 T4889 punct ],37
R2706 T4891 T4859 punct .,provided
R2707 T4893 T4894 advmod Further,appear
R2708 T4895 T4894 punct ", ",appear
R2709 T4896 T4897 mark as,shown
R2710 T4897 T4894 advcl shown,appear
R2711 T4898 T4897 advmod here,shown
R2712 T4899 T4894 punct ", ",appear
R2713 T4900 T4901 det the,vesicles
R2714 T4901 T4894 nsubj vesicles,appear
R2715 T4902 T4903 aux to,bud
R2716 T4903 T4894 xcomp bud,appear
R2717 T4904 T4903 prep from,bud
R2718 T4905 T4906 det the,segments
R2719 T4906 T4904 pobj segments,from
R2720 T4907 T4906 amod inner,segments
R2721 T4908 T4906 appos themselves,segments
R2722 T4909 T4894 punct .,appear
R2723 T4911 T4912 prep In,occurs
R2724 T4913 T4914 amod developing,photoreceptors
R2725 T4914 T4911 pobj photoreceptors,In
R2726 T4915 T4912 punct ", ",occurs
R2727 T4916 T4917 det an,process
R2728 T4917 T4912 nsubj process,occurs
R2729 T4918 T4917 amod extraordinary,process
R2730 T4919 T4917 compound growth,process
R2731 T4920 T4921 advmod whereby,generated
R2732 T4921 T4912 ccomp generated,occurs
R2733 T4922 T4923 det the,segment
R2734 T4923 T4921 nsubjpass segment,generated
R2735 T4924 T4923 amod outer,segment
R2736 T4925 T4921 auxpass is,generated
R2737 T4926 T4921 prep from,generated
R2738 T4927 T4928 det the,cilium
R2739 T4928 T4926 pobj cilium,from
R2740 T4929 T4928 amod nascent,cilium
R2741 T4930 T4928 amod connecting,cilium
R2742 T4931 T4932 punct (,see
R2743 T4932 T4912 parataxis see,occurs
R2744 T4933 T4934 punct [,38
R2745 T4934 T4932 dobj 38,see
R2746 T4935 T4934 punct ],38
R2747 T4936 T4934 cc and,38
R2748 T4937 T4934 conj references,38
R2749 T4938 T4937 advmod therein,references
R2750 T4939 T4932 punct ),see
R2751 T4940 T4912 punct .,occurs
R2752 T4942 T4943 nmod Peripherin,RDS
R2753 T4943 T4945 nmod RDS,proteins
R2754 T4944 T4943 punct /,RDS
R2755 T4945 T4950 nsubj proteins,have
R2756 T4946 T4943 cc and,RDS
R2757 T4947 T4943 conj ROM,RDS
R2758 T4948 T4947 punct -,ROM
R2759 T4949 T4947 nummod 1,ROM
R2760 T4951 T4945 punct (,proteins
R2761 T4952 T4945 acl localized,proteins
R2762 T4953 T4952 prep in,localized
R2763 T4954 T4955 compound disc,rims
R2764 T4955 T4953 pobj rims,in
R2765 T4956 T4945 punct ),proteins
R2766 T4957 T4945 cc and,proteins
R2767 T4958 T4959 det the,proteins
R2768 T4959 T4945 conj proteins,proteins
R2769 T4960 T4959 compound opsin,proteins
R2770 T4961 T4959 punct (,proteins
R2771 T4962 T4959 acl localized,proteins
R2772 T4963 T4962 prep throughout,localized
R2773 T4964 T4965 det the,discs
R2774 T4965 T4963 pobj discs,throughout
R2775 T4966 T4950 punct ),have
R2776 T4967 T4968 amod important,roles
R2777 T4968 T4950 dobj roles,have
R2778 T4969 T4968 prep in,roles
R2779 T4970 T4971 det the,integrity
R2780 T4971 T4969 pobj integrity,in
R2781 T4972 T4971 amod structural,integrity
R2782 T4973 T4971 prep of,integrity
R2783 T4974 T4975 amod mature,segments
R2784 T4975 T4973 pobj segments,of
R2785 T4976 T4975 amod outer,segments
R2786 T4977 T4978 punct (,see
R2787 T4978 T4950 parataxis see,have
R2788 T4979 T4978 punct [,see
R2789 T4980 T4981 nummod 39,29
R2790 T4981 T4978 dobj 29,see
R2791 T4982 T4981 punct ",",29
R2792 T4983 T4978 punct ],see
R2793 T4984 T4978 punct ),see
R2794 T4985 T4950 punct .,have
R2795 T4987 T4988 nmod ROM,mice
R2796 T4988 T4994 nsubj mice,produce
R2797 T4989 T4987 punct -,ROM
R2798 T4990 T4987 nummod 1,ROM
R2799 T4991 T4987 punct -,ROM
R2800 T4992 T4987 punct /,ROM
R2801 T4993 T4987 punct -,ROM
R2802 T4995 T4996 amod disorganized,segments
R2803 T4996 T4994 dobj segments,produce
R2804 T4997 T4996 amod outer,segments
R2805 T4998 T4996 prep with,segments
R2806 T4999 T5000 amod large,disks
R2807 T5000 T4998 pobj disks,with
R2808 T5001 T5002 punct [,40
R2809 T5002 T4994 parataxis 40,produce
R2810 T5003 T5002 punct ],40
R2811 T5004 T4994 punct .,produce
R2812 T5006 T5007 nsubj Crx,controls
R2813 T5008 T5007 punct ", ",controls
R2814 T5009 T5007 prep by,controls
R2815 T5010 T5009 pobj virtue,by
R2816 T5011 T5010 prep of,virtue
R2817 T5012 T5011 pcomp being,of
R2818 T5013 T5014 det a,factor
R2819 T5014 T5012 attr factor,being
R2820 T5015 T5014 compound transcription,factor
R2821 T5016 T5007 punct ", ",controls
R2822 T5017 T5007 advmod presumably,controls
R2823 T5018 T5007 dobj genes,controls
R2824 T5019 T5020 dep that,are
R2825 T5020 T5018 relcl are,genes
R2826 T5021 T5020 acomp responsible,are
R2827 T5022 T5021 prep for,responsible
R2828 T5023 T5024 det the,building
R2829 T5024 T5022 pobj building,for
R2830 T5025 T5024 cc and,building
R2831 T5026 T5027 advmod perhaps,maintenance
R2832 T5027 T5024 conj maintenance,building
R2833 T5028 T5024 prep of,building
R2834 T5029 T5030 det the,structure
R2835 T5030 T5028 pobj structure,of
R2836 T5031 T5032 amod outer,segment
R2837 T5032 T5030 compound segment,structure
R2838 T5033 T5018 punct ", ",genes
R2839 T5034 T5018 prep including,genes
R2840 T5035 T5034 pobj rhodopsin,including
R2841 T5036 T5035 cc and,rhodopsin
R2842 T5037 T5035 conj peripherin,rhodopsin
R2843 T5038 T5007 punct .,controls
R2844 T5040 T5041 advcl Using,defined
R2845 T5042 T5043 compound northern,blots
R2846 T5043 T5040 dobj blots,Using
R2847 T5044 T5045 punct [,34
R2848 T5045 T5043 parataxis 34,blots
R2849 T5046 T5045 punct ],34
R2850 T5047 T5043 punct ", ",blots
R2851 T5048 T5043 conj microarrays,blots
R2852 T5049 T5050 punct [,10
R2853 T5050 T5048 parataxis 10,microarrays
R2854 T5051 T5050 punct ],10
R2855 T5052 T5048 punct ", ",microarrays
R2856 T5053 T5048 cc and,microarrays
R2857 T5054 T5055 amod serial,analysis
R2858 T5055 T5048 conj analysis,microarrays
R2859 T5056 T5055 prep of,analysis
R2860 T5057 T5058 compound gene,expression
R2861 T5058 T5056 pobj expression,of
R2862 T5059 T5055 punct (,analysis
R2863 T5060 T5055 appos SAGE,analysis
R2864 T5061 T5055 punct ),analysis
R2865 T5062 T5063 punct [,35
R2866 T5063 T5055 parataxis 35,analysis
R2867 T5064 T5063 punct ],35
R2868 T5065 T5041 punct ", ",defined
R2869 T5066 T5041 nsubj we,defined
R2870 T5067 T5041 aux have,defined
R2871 T5068 T5069 det a,number
R2872 T5069 T5041 dobj number,defined
R2873 T5070 T5069 amod large,number
R2874 T5071 T5069 prep of,number
R2875 T5072 T5071 pobj genes,of
R2876 T5073 T5074 dep that,altered
R2877 T5074 T5072 relcl altered,genes
R2878 T5075 T5074 auxpass are,altered
R2879 T5076 T5074 prep in,altered
R2880 T5077 T5078 poss their,level
R2881 T5078 T5076 pobj level,in
R2882 T5079 T5078 compound expression,level
R2883 T5080 T5074 prep in,altered
R2884 T5081 T5082 nmod Crx,mice
R2885 T5082 T5080 pobj mice,in
R2886 T5083 T5081 punct -,Crx
R2887 T5084 T5081 punct /,Crx
R2888 T5085 T5081 punct -,Crx
R2889 T5086 T5041 punct .,defined
R2890 T5088 T5089 nsubj We,found
R2891 T5090 T5091 mark that,diminished
R2892 T5091 T5089 ccomp diminished,found
R2893 T5092 T5093 compound rhodopsin,expression
R2894 T5093 T5091 nsubjpass expression,diminished
R2895 T5094 T5091 auxpass was,diminished
R2896 T5095 T5091 advmod severely,diminished
R2897 T5096 T5091 prep in,diminished
R2898 T5097 T5098 nmod Crx,animals
R2899 T5098 T5096 pobj animals,in
R2900 T5099 T5097 punct -,Crx
R2901 T5100 T5097 punct /,Crx
R2902 T5101 T5097 punct -,Crx
R2903 T5102 T5091 punct ", ",diminished
R2904 T5103 T5091 cc and,diminished
R2905 T5104 T5105 compound peripherin,mRNA
R2906 T5105 T5106 nsubjpass mRNA,reduced
R2907 T5106 T5091 conj reduced,diminished
R2908 T5107 T5106 auxpass was,reduced
R2909 T5108 T5106 prep by,reduced
R2910 T5109 T5110 advmod approximately,30
R2911 T5110 T5111 nummod 30,%
R2912 T5111 T5108 pobj %,by
R2913 T5112 T5089 punct .,found
R2914 T5114 T5115 amod Transgenic,mice
R2915 T5115 T5116 nsubj mice,exhibit
R2916 T5117 T5115 prep with,mice
R2917 T5118 T5119 amod variable,levels
R2918 T5119 T5117 pobj levels,with
R2919 T5120 T5119 prep of,levels
R2920 T5121 T5120 pobj expression,of
R2921 T5122 T5121 prep of,expression
R2922 T5123 T5124 amod wild,type
R2923 T5124 T5125 compound type,rhodopsin
R2924 T5125 T5122 pobj rhodopsin,of
R2925 T5126 T5127 compound rod,degeneration
R2926 T5127 T5116 dobj degeneration,exhibit
R2927 T5128 T5129 punct [,41
R2928 T5129 T5116 parataxis 41,exhibit
R2929 T5130 T5129 punct ],41
R2930 T5131 T5116 punct ", ",exhibit
R2931 T5132 T5116 advcl indicating,exhibit
R2932 T5133 T5134 det the,importance
R2933 T5134 T5132 dobj importance,indicating
R2934 T5135 T5134 prep of,importance
R2935 T5136 T5137 det the,level
R2936 T5137 T5135 pobj level,of
R2937 T5138 T5137 prep of,level
R2938 T5139 T5140 compound rhodopsin,expression
R2939 T5140 T5138 pobj expression,of
R2940 T5141 T5116 punct .,exhibit
R2941 T5143 T5144 prep In,be
R2942 T5145 T5143 pobj addition,In
R2943 T5146 T5144 punct ", ",be
R2944 T5147 T5148 det the,timing
R2945 T5148 T5144 nsubj timing,be
R2946 T5149 T5148 prep of,timing
R2947 T5150 T5151 compound rhodopsin,expression
R2948 T5151 T5149 pobj expression,of
R2949 T5152 T5144 aux may,be
R2950 T5153 T5154 advmod very,important
R2951 T5154 T5144 acomp important,be
R2952 T5155 T5144 punct ", ",be
R2953 T5156 T5157 mark as,indicated
R2954 T5157 T5144 advcl indicated,be
R2955 T5158 T5157 agent by,indicated
R2956 T5159 T5158 pobj studies,by
R2957 T5160 T5159 prep in,studies
R2958 T5161 T5160 pobj Drosophila,in
R2959 T5162 T5144 punct .,be
R2960 T5164 T5165 prep In,expressed
R2961 T5166 T5164 pobj Drosophila,In
R2962 T5167 T5165 punct ", ",expressed
R2963 T5168 T5165 nsubjpass rhodopsin,expressed
R2964 T5169 T5170 punct (,ninaE
R2965 T5170 T5168 parataxis ninaE,rhodopsin
R2966 T5171 T5170 punct ),ninaE
R2967 T5172 T5165 auxpass is,expressed
R2968 T5173 T5165 prep in,expressed
R2969 T5174 T5175 compound photoreceptors,R1
R2970 T5175 T5173 pobj R1,in
R2971 T5176 T5177 punct –,R6
R2972 T5177 T5175 prep R6,R1
R2973 T5178 T5165 punct .,expressed
R2974 T5180 T5181 prep In,fails
R2975 T5182 T5183 npadvmod ninaE,null
R2976 T5183 T5184 amod null,mutants
R2977 T5184 T5180 pobj mutants,In
R2978 T5185 T5181 punct ", ",fails
R2979 T5186 T5187 det the,rhabdomere
R2980 T5187 T5181 nsubj rhabdomere,fails
R2981 T5188 T5187 punct ", ",rhabdomere
R2982 T5189 T5190 det a,structure
R2983 T5190 T5187 appos structure,rhabdomere
R2984 T5191 T5190 amod analogous,structure
R2985 T5192 T5191 prep to,analogous
R2986 T5193 T5194 nmod vertebrate,segments
R2987 T5194 T5192 pobj segments,to
R2988 T5195 T5194 amod outer,segments
R2989 T5196 T5181 punct ", ",fails
R2990 T5197 T5198 aux to,develop
R2991 T5198 T5181 xcomp develop,fails
R2992 T5199 T5198 prep in,develop
R2993 T5200 T5201 nmod R1,photoreceptors
R2994 T5201 T5199 pobj photoreceptors,in
R2995 T5202 T5203 punct –,R6
R2996 T5203 T5200 prep R6,R1
R2997 T5204 T5205 punct [,42
R2998 T5205 T5198 parataxis 42,develop
R2999 T5206 T5205 punct ],42
R3000 T5207 T5198 punct ", ",develop
R3001 T5208 T5198 advcl reminiscent,develop
R3002 T5209 T5208 prep of,reminiscent
R3003 T5210 T5211 det the,situation
R3004 T5211 T5209 pobj situation,of
R3005 T5212 T5211 prep in,situation
R3006 T5213 T5214 nmod rhodopsin,mice
R3007 T5214 T5212 pobj mice,in
R3008 T5215 T5213 punct -,rhodopsin
R3009 T5216 T5213 punct /,rhodopsin
R3010 T5217 T5213 punct -,rhodopsin
R3011 T5218 T5219 punct [,29
R3012 T5219 T5208 parataxis 29,reminiscent
R3013 T5220 T5219 punct ],29
R3014 T5221 T5181 punct .,fails
R3015 T5223 T5224 det An,experiment
R3016 T5224 T5226 nsubj experiment,demonstrated
R3017 T5225 T5224 amod intriguing,experiment
R3018 T5227 T5224 prep by,experiment
R3019 T5228 T5227 pobj Kumar,by
R3020 T5229 T5230 advmod et,al.
R3021 T5230 T5228 advmod al.,Kumar
R3022 T5231 T5232 punct [,43
R3023 T5232 T5228 parataxis 43,Kumar
R3024 T5233 T5232 punct ],43
R3025 T5234 T5235 det a,requirement
R3026 T5235 T5226 dobj requirement,demonstrated
R3027 T5236 T5235 amod temporal,requirement
R3028 T5237 T5235 prep for,requirement
R3029 T5238 T5239 compound rhodopsin,expression
R3030 T5239 T5237 pobj expression,for
R3031 T5240 T5235 prep during,requirement
R3032 T5241 T5242 compound rhabdomere,development
R3033 T5242 T5240 pobj development,during
R3034 T5243 T5226 punct .,demonstrated
R3035 T5245 T5246 prep In,subjected
R3036 T5247 T5248 npadvmod ninaE,null
R3037 T5248 T5249 amod null,flies
R3038 T5249 T5245 pobj flies,In
R3039 T5250 T5246 punct ", ",subjected
R3040 T5251 T5252 det a,transgene
R3041 T5252 T5246 nsubjpass transgene,subjected
R3042 T5253 T5252 compound ninaE,transgene
R3043 T5254 T5252 prep under,transgene
R3044 T5255 T5256 det the,control
R3045 T5256 T5254 pobj control,under
R3046 T5257 T5256 prep of,control
R3047 T5258 T5259 det a,promoter
R3048 T5259 T5257 pobj promoter,of
R3049 T5260 T5261 compound heat,shock
R3050 T5261 T5259 compound shock,promoter
R3051 T5262 T5246 auxpass was,subjected
R3052 T5263 T5246 prep to,subjected
R3053 T5264 T5265 amod various,shifts
R3054 T5265 T5263 pobj shifts,to
R3055 T5266 T5265 compound temperature,shifts
R3056 T5267 T5246 prep during,subjected
R3057 T5268 T5267 pobj development,during
R3058 T5269 T5246 punct .,subjected
R3059 T5271 T5272 compound Heat,shock
R3060 T5272 T5273 nsubj shock,resulted
R3061 T5274 T5272 prep during,shock
R3062 T5275 T5276 det the,time
R3063 T5276 T5274 pobj time,during
R3064 T5277 T5276 amod normal,time
R3065 T5278 T5276 prep of,time
R3066 T5279 T5280 compound rhodopsin,onset
R3067 T5280 T5278 pobj onset,of
R3068 T5281 T5273 prep in,resulted
R3069 T5282 T5283 amod substantial,rescue
R3070 T5283 T5281 pobj rescue,in
R3071 T5284 T5282 cc and,substantial
R3072 T5285 T5286 advmod long,lasting
R3073 T5286 T5282 conj lasting,substantial
R3074 T5287 T5286 punct -,lasting
R3075 T5288 T5283 prep of,rescue
R3076 T5289 T5290 compound photoreceptor,structure
R3077 T5290 T5288 pobj structure,of
R3078 T5291 T5283 cc and,rescue
R3079 T5292 T5293 amod transient,rescue
R3080 T5293 T5283 conj rescue,rescue
R3081 T5294 T5293 prep of,rescue
R3082 T5295 T5296 compound photoreceptor,physiology
R3083 T5296 T5294 pobj physiology,of
R3084 T5297 T5273 punct .,resulted
R3085 T5299 T5300 advmod However,failed
R3086 T5301 T5300 punct ", ",failed
R3087 T5302 T5300 nsubj expression,failed
R3088 T5303 T5304 advmod shortly,before
R3089 T5304 T5302 prep before,expression
R3090 T5305 T5304 cc or,before
R3091 T5306 T5304 conj after,before
R3092 T5307 T5308 det this,period
R3093 T5308 T5306 pobj period,after
R3094 T5309 T5308 amod critical,period
R3095 T5310 T5311 aux to,rescue
R3096 T5311 T5300 xcomp rescue,failed
R3097 T5312 T5300 punct ", ",failed
R3098 T5313 T5300 advcl suggesting,failed
R3099 T5314 T5315 mark that,is
R3100 T5315 T5313 ccomp is,suggesting
R3101 T5316 T5317 compound rhodopsin,expression
R3102 T5317 T5315 nsubj expression,is
R3103 T5318 T5317 prep during,expression
R3104 T5319 T5320 det a,window
R3105 T5320 T5318 pobj window,during
R3106 T5321 T5320 amod discrete,window
R3107 T5322 T5320 prep of,window
R3108 T5323 T5322 pobj time,of
R3109 T5324 T5320 prep in,window
R3110 T5325 T5324 pobj development,in
R3111 T5326 T5315 acomp essential,is
R3112 T5327 T5326 prep for,essential
R3113 T5328 T5329 amod proper,morphogenesis
R3114 T5329 T5327 pobj morphogenesis,for
R3115 T5330 T5329 amod rhabdomere,morphogenesis
R3116 T5331 T5300 punct .,failed
R3117 T5333 T5334 det This,result
R3118 T5334 T5335 nsubj result,is
R3119 T5336 T5335 acomp consistent,is
R3120 T5337 T5336 prep with,consistent
R3121 T5338 T5337 pobj observations,with
R3122 T5339 T5338 prep in,observations
R3123 T5340 T5341 det the,rat
R3124 T5341 T5339 pobj rat,in
R3125 T5342 T5343 prep wherein,occurs
R3126 T5343 T5338 relcl occurs,observations
R3127 T5344 T5345 compound rhodopsin,onset
R3128 T5345 T5343 nsubj onset,occurs
R3129 T5346 T5343 prep with,occurs
R3130 T5347 T5348 amod strict,timing
R3131 T5348 T5346 pobj timing,with
R3132 T5349 T5343 prep in,occurs
R3133 T5350 T5351 det the,history
R3134 T5351 T5349 pobj history,in
R3135 T5352 T5351 amod developmental,history
R3136 T5353 T5351 prep of,history
R3137 T5354 T5355 amod most,rods
R3138 T5355 T5353 pobj rods,of
R3139 T5356 T5357 advmod in,vivo
R3140 T5357 T5343 advmod vivo,occurs
R3141 T5358 T5359 punct [,44
R3142 T5359 T5338 parataxis 44,observations
R3143 T5360 T5359 punct ],44
R3144 T5361 T5335 punct .,is
R3145 T5363 T5364 advmod Thus,regulating
R3146 T5365 T5364 punct ", ",regulating
R3147 T5366 T5364 prep through,regulating
R3148 T5367 T5368 poss its,regulation
R3149 T5368 T5366 pobj regulation,through
R3150 T5369 T5368 prep of,regulation
R3151 T5370 T5371 compound rhodopsin,levels
R3152 T5371 T5369 pobj levels,of
R3153 T5372 T5366 punct ", ",through
R3154 T5373 T5366 cc or,through
R3155 T5374 T5375 advmod perhaps,through
R3156 T5375 T5366 conj through,through
R3157 T5376 T5375 pobj control,through
R3158 T5377 T5376 prep of,control
R3159 T5378 T5379 det the,kinetics
R3160 T5379 T5377 pobj kinetics,of
R3161 T5380 T5379 prep of,kinetics
R3162 T5381 T5382 det the,regulation
R3163 T5382 T5380 pobj regulation,of
R3164 T5383 T5382 amod up,regulation
R3165 T5384 T5382 punct -,regulation
R3166 T5385 T5382 prep of,regulation
R3167 T5386 T5385 pobj rhodopsin,of
R3168 T5387 T5382 acl beginning,regulation
R3169 T5388 T5387 prep at,beginning
R3170 T5389 T5390 advmod about,P6
R3171 T5390 T5388 pobj P6,at
R3172 T5391 T5364 punct ", ",regulating
R3173 T5392 T5364 nsubj Crx,regulating
R3174 T5393 T5364 aux may,regulating
R3175 T5394 T5364 aux be,regulating
R3176 T5395 T5396 amod outer,segment
R3177 T5396 T5397 compound segment,morphogenesis
R3178 T5397 T5364 dobj morphogenesis,regulating
R3179 T5398 T5364 punct .,regulating
R3180 T5400 T5401 det The,similarty
R3181 T5401 T5402 nsubj similarty,extend
R3182 T5403 T5401 prep of,similarty
R3183 T5404 T5405 det the,cases
R3184 T5405 T5403 pobj cases,of
R3185 T5406 T5405 nummod two,cases
R3186 T5407 T5402 aux may,extend
R3187 T5408 T5402 advmod further,extend
R3188 T5409 T5402 punct .,extend
R3189 T5411 T5412 prep At,is
R3190 T5413 T5411 amod present,At
R3191 T5414 T5412 punct ", ",is
R3192 T5415 T5416 det the,Crx
R3193 T5416 T5412 nsubj Crx,is
R3194 T5417 T5416 amod closest,Crx
R3195 T5418 T5416 amod relative,Crx
R3196 T5419 T5416 prep in,Crx
R3197 T5420 T5419 pobj Drosophila,in
R3198 T5421 T5412 attr Otd,is
R3199 T5422 T5421 punct ", ",Otd
R3200 T5423 T5424 det the,member
R3201 T5424 T5421 appos member,Otd
R3202 T5425 T5424 amod founding,member
R3203 T5426 T5424 prep of,member
R3204 T5427 T5428 det the,class
R3205 T5428 T5426 pobj class,of
R3206 T5429 T5428 prep of,class
R3207 T5430 T5431 compound homeobox,genes
R3208 T5431 T5429 pobj genes,of
R3209 T5432 T5433 prep to,belongs
R3210 T5433 T5431 relcl belongs,genes
R3211 T5434 T5432 pobj which,to
R3212 T5435 T5433 nsubj Crx,belongs
R3213 T5436 T5412 punct .,is
R3214 T5438 T5439 advmod Interestingly,disrupted
R3215 T5440 T5439 punct ", ",disrupted
R3216 T5441 T5439 prep in,disrupted
R3217 T5442 T5443 nummod one,allele
R3218 T5443 T5441 pobj allele,in
R3219 T5444 T5443 amod hypomorphic,allele
R3220 T5445 T5443 prep of,allele
R3221 T5446 T5447 compound Drosophila,otd
R3222 T5447 T5445 pobj otd,of
R3223 T5448 T5443 punct ", ",allele
R3224 T5449 T5443 appos otduvi,allele
R3225 T5450 T5439 punct ", ",disrupted
R3226 T5451 T5452 compound photoreceptor,morphogenesis
R3227 T5452 T5439 nsubjpass morphogenesis,disrupted
R3228 T5453 T5439 auxpass is,disrupted
R3229 T5454 T5439 advmod also,disrupted
R3230 T5455 T5456 punct [,45
R3231 T5456 T5439 parataxis 45,disrupted
R3232 T5457 T5456 punct ],45
R3233 T5458 T5439 punct .,disrupted
R3234 T5460 T5461 nsubj We,found
R3235 T5462 T5463 mark that,are
R3236 T5463 T5461 ccomp are,found
R3237 T5464 T5463 expl there,are
R3238 T5465 T5466 amod many,genes
R3239 T5466 T5463 attr genes,are
R3240 T5467 T5466 amod other,genes
R3241 T5468 T5469 dep that,are
R3242 T5469 T5466 relcl are,genes
R3243 T5470 T5469 acomp dependent,are
R3244 T5471 T5470 prep upon,dependent
R3245 T5472 T5471 pobj Crx,upon
R3246 T5473 T5461 punct .,found
R3247 T5475 T5476 nsubj Those,comprise
R3248 T5477 T5478 dep that,expressed
R3249 T5478 T5475 relcl expressed,Those
R3250 T5479 T5478 auxpass are,expressed
R3251 T5480 T5478 prep at,expressed
R3252 T5481 T5482 det a,level
R3253 T5482 T5480 pobj level,at
R3254 T5483 T5482 amod lower,level
R3255 T5484 T5478 prep in,expressed
R3256 T5485 T5486 det the,retina
R3257 T5486 T5484 pobj retina,in
R3258 T5487 T5486 nmod Crx,retina
R3259 T5488 T5487 punct -,Crx
R3260 T5489 T5487 punct /,Crx
R3261 T5490 T5487 punct -,Crx
R3262 T5491 T5475 punct ", ",Those
R3263 T5492 T5493 amod such,as
R3264 T5493 T5475 prep as,Those
R3265 T5494 T5493 pobj rhodopsin,as
R3266 T5495 T5494 cc and,rhodopsin
R3267 T5496 T5494 conj peripherin,rhodopsin
R3268 T5497 T5476 punct ", ",comprise
R3269 T5498 T5476 dobj many,comprise
R3270 T5499 T5500 dep that,are
R3271 T5500 T5498 relcl are,many
R3272 T5501 T5502 advmod either,enriched
R3273 T5502 T5500 acomp enriched,are
R3274 T5503 T5502 cc or,enriched
R3275 T5504 T5502 conj specific,enriched
R3276 T5505 T5504 prep to,specific
R3277 T5506 T5505 pobj photoreceptors,to
R3278 T5507 T5500 prep in,are
R3279 T5508 T5509 poss their,expression
R3280 T5509 T5507 pobj expression,in
R3281 T5510 T5511 punct [,35
R3282 T5511 T5476 parataxis 35,comprise
R3283 T5512 T5511 punct ],35
R3284 T5513 T5476 punct .,comprise
R3285 T5515 T5516 nsubj They,include
R3286 T5517 T5516 dobj enzymes,include
R3287 T5518 T5519 dep that,are
R3288 T5519 T5517 relcl are,enzymes
R3289 T5520 T5519 acomp important,are
R3290 T5521 T5520 prep in,important
R3291 T5522 T5523 compound lipid,metabolism
R3292 T5523 T5521 pobj metabolism,in
R3293 T5524 T5523 punct ", ",metabolism
R3294 T5525 T5526 compound protein,folding
R3295 T5526 T5523 appos folding,metabolism
R3296 T5527 T5526 cc and,folding
R3297 T5528 T5526 conj transport,folding
R3298 T5529 T5521 punct ", ",in
R3299 T5530 T5531 advmod as,as
R3300 T5531 T5521 cc as,in
R3301 T5532 T5531 advmod well,as
R3302 T5533 T5521 conj in,in
R3303 T5534 T5535 amod other,processes
R3304 T5535 T5533 pobj processes,in
R3305 T5536 T5537 dep that,envision
R3306 T5537 T5535 relcl envision,processes
R3307 T5538 T5537 nsubj one,envision
R3308 T5539 T5537 aux might,envision
R3309 T5540 T5541 aux would,be
R3310 T5541 T5537 xcomp be,envision
R3311 T5542 T5541 acomp important,be
R3312 T5543 T5541 prep in,be
R3313 T5544 T5543 pcomp building,in
R3314 T5545 T5546 det a,structure
R3315 T5546 T5544 dobj structure,building
R3316 T5547 T5548 amod such,as
R3317 T5548 T5546 prep as,structure
R3318 T5549 T5550 det the,segment
R3319 T5550 T5548 pobj segment,as
R3320 T5551 T5550 amod outer,segment
R3321 T5552 T5516 punct .,include
R3322 T5554 T5555 advmod In,situ
R3323 T5555 T5556 amod situ,hybridization
R3324 T5556 T5557 nsubj hybridization,revealed
R3325 T5558 T5556 acl using,hybridization
R3326 T5559 T5558 dobj probes,using
R3327 T5560 T5559 prep from,probes
R3328 T5561 T5562 det this,collection
R3329 T5562 T5560 pobj collection,from
R3330 T5563 T5562 prep of,collection
R3331 T5564 T5563 pobj genes,of
R3332 T5565 T5557 aux has,revealed
R3333 T5566 T5567 mark that,have
R3334 T5567 T5557 ccomp have,revealed
R3335 T5568 T5567 nsubj some,have
R3336 T5569 T5568 prep of,some
R3337 T5570 T5569 pobj them,of
R3338 T5571 T5572 poss their,RNA
R3339 T5572 T5573 nsubj RNA,localized
R3340 T5573 T5567 ccomp localized,have
R3341 T5574 T5573 prep to,localized
R3342 T5575 T5576 det the,segment
R3343 T5576 T5574 pobj segment,to
R3344 T5577 T5576 amod inner,segment
R3345 T5578 T5557 punct ", ",revealed
R3346 T5579 T5580 det a,finding
R3347 T5580 T5557 npadvmod finding,revealed
R3348 T5581 T5580 amod typical,finding
R3349 T5582 T5581 prep for,typical
R3350 T5583 T5582 pobj proteins,for
R3351 T5584 T5583 acl targeted,proteins
R3352 T5585 T5584 prep to,targeted
R3353 T5586 T5587 det the,segment
R3354 T5587 T5585 pobj segment,to
R3355 T5588 T5587 amod outer,segment
R3356 T5589 T5557 punct .,revealed
R3357 T5591 T5592 amod Future,analyses
R3358 T5592 T5593 nsubj analyses,reveal
R3359 T5594 T5592 prep of,analyses
R3360 T5595 T5596 det the,function
R3361 T5596 T5594 pobj function,of
R3362 T5597 T5596 prep of,function
R3363 T5598 T5599 det these,genes
R3364 T5599 T5597 pobj genes,of
R3365 T5600 T5593 aux might,reveal
R3366 T5601 T5602 poss their,role
R3367 T5602 T5593 dobj role,reveal
R3368 T5603 T5602 prep in,role
R3369 T5604 T5605 amod outer,segment
R3370 T5605 T5606 compound segment,biogenesis
R3371 T5606 T5603 pobj biogenesis,in
R3372 T5607 T5593 punct .,reveal
R3373 T5609 T5610 advmod Finally,found
R3374 T5611 T5610 punct ", ",found
R3375 T5612 T5610 nsubjpass polarization,found
R3376 T5613 T5612 prep of,polarization
R3377 T5614 T5613 pobj photoreceptors,of
R3378 T5615 T5610 auxpass was,found
R3379 T5616 T5617 aux to,be
R3380 T5617 T5610 xcomp be,found
R3381 T5618 T5619 advmod largely,intact
R3382 T5619 T5617 acomp intact,be
R3383 T5620 T5617 punct ", ",be
R3384 T5621 T5622 mark as,was
R3385 T5622 T5617 advcl was,be
R3386 T5623 T5622 nsubj ciliogenesis,was
R3387 T5624 T5610 punct .,found
R3388 T5626 T5627 det Another,gene
R3389 T5627 T5629 nsubjpass gene,implicated
R3390 T5628 T5627 compound LCA,gene
R3391 T5630 T5627 punct ", ",gene
R3392 T5631 T5627 appos CRB1,gene
R3393 T5632 T5627 punct ", ",gene
R3394 T5633 T5627 cc and,gene
R3395 T5634 T5635 det a,gene
R3396 T5635 T5627 conj gene,gene
R3397 T5636 T5635 amod related,gene
R3398 T5637 T5635 appos CRB3,gene
R3399 T5638 T5629 punct ", ",implicated
R3400 T5639 T5629 aux have,implicated
R3401 T5640 T5629 auxpass been,implicated
R3402 T5641 T5629 prep in,implicated
R3403 T5642 T5641 pobj ciliogenesis,in
R3404 T5643 T5629 prep in,implicated
R3405 T5644 T5645 advmod in,vitro
R3406 T5645 T5646 amod vitro,models
R3407 T5646 T5643 pobj models,in
R3408 T5647 T5648 punct [,46
R3409 T5648 T5629 parataxis 46,implicated
R3410 T5649 T5648 punct ],46
R3411 T5650 T5629 punct .,implicated
R3412 T5652 T5653 det The,homologue
R3413 T5653 T5655 nsubjpass homologue,implicated
R3414 T5654 T5653 compound Drosophila,homologue
R3415 T5656 T5653 prep of,homologue
R3416 T5657 T5656 pobj CRB1,of
R3417 T5658 T5653 punct ", ",homologue
R3418 T5659 T5653 appos Crumbs,homologue
R3419 T5660 T5655 punct ", ",implicated
R3420 T5661 T5655 aux has,implicated
R3421 T5662 T5655 auxpass been,implicated
R3422 T5663 T5655 prep in,implicated
R3423 T5664 T5665 compound photoreceptor,morphogenesis
R3424 T5665 T5663 pobj morphogenesis,in
R3425 T5666 T5667 punct [,47
R3426 T5667 T5655 parataxis 47,implicated
R3427 T5668 T5667 punct ],47
R3428 T5669 T5655 punct .,implicated
R3429 T5671 T5672 advmod However,develops
R3430 T5673 T5672 punct ", ",develops
R3431 T5674 T5675 det the,mutant
R3432 T5675 T5672 nsubj mutant,develops
R3433 T5676 T5677 advmod spontaneously,occurring
R3434 T5677 T5675 amod occurring,mutant
R3435 T5678 T5675 compound mouse,mutant
R3436 T5679 T5675 prep in,mutant
R3437 T5680 T5679 pobj CRB1,in
R3438 T5681 T5675 punct ", ",mutant
R3439 T5682 T5683 det the,mouse
R3440 T5683 T5675 appos mouse,mutant
R3441 T5684 T5683 compound Rd8,mouse
R3442 T5685 T5672 punct ", ",develops
R3443 T5686 T5687 amod shortened,segments
R3444 T5687 T5672 dobj segments,develops
R3445 T5688 T5687 amod outer,segments
R3446 T5689 T5690 dep that,degenerate
R3447 T5690 T5687 relcl degenerate,segments
R3448 T5691 T5690 advmod subsequently,degenerate
R3449 T5692 T5693 punct [,48
R3450 T5693 T5672 parataxis 48,develops
R3451 T5694 T5693 punct ],48
R3452 T5695 T5672 punct ", ",develops
R3453 T5696 T5672 advcl suggesting,develops
R3454 T5697 T5698 mark that,are
R3455 T5698 T5696 ccomp are,suggesting
R3456 T5699 T5700 compound photoreceptor,polarization
R3457 T5700 T5698 nsubj polarization,are
R3458 T5701 T5700 cc and,polarization
R3459 T5702 T5700 conj synaptogenesis,polarization
R3460 T5703 T5698 acomp intact,are
R3461 T5704 T5698 prep in,are
R3462 T5705 T5706 det this,mutant
R3463 T5706 T5704 pobj mutant,in
R3464 T5707 T5672 punct .,develops
R3465 T5709 T5710 mark While,linked
R3466 T5710 T5717 advcl linked,is
R3467 T5711 T5710 nsubjpass CRB1,linked
R3468 T5712 T5711 cc and,CRB1
R3469 T5713 T5711 conj Crx,CRB1
R3470 T5714 T5710 aux have,linked
R3471 T5715 T5710 auxpass been,linked
R3472 T5716 T5710 advmod both,linked
R3473 T5718 T5710 prep to,linked
R3474 T5719 T5718 pobj LCA,to
R3475 T5720 T5717 punct ", ",is
R3476 T5721 T5722 amod further,work
R3477 T5722 T5717 nsubj work,is
R3478 T5723 T5717 acomp necessary,is
R3479 T5724 T5725 aux to,determine
R3480 T5725 T5723 xcomp determine,necessary
R3481 T5726 T5727 mark if,linked
R3482 T5727 T5725 ccomp linked,determine
R3483 T5728 T5729 poss their,function
R3484 T5729 T5727 nsubjpass function,linked
R3485 T5730 T5727 auxpass is,linked
R3486 T5731 T5727 prep in,linked
R3487 T5732 T5733 amod retinal,development
R3488 T5733 T5731 pobj development,in
R3489 T5734 T5717 punct .,is
R3492 T6165 T6166 nsubjpass Synaptogenesis,perturbed
R3493 T6167 T6166 auxpass is,perturbed
R3494 T6168 T6166 prep in,perturbed
R3495 T6169 T6170 nmod Crx,photoreceptors
R3496 T6170 T6168 pobj photoreceptors,in
R3497 T6171 T6169 punct -,Crx
R3498 T6172 T6169 punct /,Crx
R3499 T6173 T6169 punct -,Crx
R3500 T6175 T6176 det The,mouse
R3501 T6176 T6181 nsubj mouse,demonstrates
R3502 T6177 T6176 nmod Crx,mouse
R3503 T6178 T6177 punct -,Crx
R3504 T6179 T6177 punct /,Crx
R3505 T6180 T6177 punct -,Crx
R3506 T6182 T6183 det the,abnormality
R3507 T6183 T6181 dobj abnormality,demonstrates
R3508 T6184 T6185 advmod most,severe
R3509 T6185 T6183 amod severe,abnormality
R3510 T6186 T6183 prep of,abnormality
R3511 T6187 T6188 compound photoreceptor,synapses
R3512 T6188 T6186 pobj synapses,of
R3513 T6189 T6183 acl reported,abnormality
R3514 T6190 T6189 prep to,reported
R3515 T6191 T6190 pobj date,to
R3516 T6192 T6181 punct .,demonstrates
R3517 T6194 T6195 det The,mouse
R3518 T6195 T6200 nsubj mouse,develops
R3519 T6196 T6195 nmod peripherin,mouse
R3520 T6197 T6196 punct -,peripherin
R3521 T6198 T6196 punct /,peripherin
R3522 T6199 T6196 punct -,peripherin
R3523 T6201 T6202 det a,complement
R3524 T6202 T6200 dobj complement,develops
R3525 T6203 T6202 amod normal,complement
R3526 T6204 T6202 prep of,complement
R3527 T6205 T6206 compound photoreceptor,terminals
R3528 T6206 T6204 pobj terminals,of
R3529 T6207 T6208 dep which,degenerate
R3530 T6208 T6202 relcl degenerate,complement
R3531 T6209 T6208 advmod then,degenerate
R3532 T6210 T6211 mark as,lost
R3533 T6211 T6208 advcl lost,degenerate
R3534 T6212 T6213 det the,photoreceptors
R3535 T6213 T6211 nsubjpass photoreceptors,lost
R3536 T6214 T6211 auxpass are,lost
R3537 T6215 T6216 punct [,30
R3538 T6216 T6200 parataxis 30,develops
R3539 T6217 T6216 punct ],30
R3540 T6218 T6200 punct .,develops
R3541 T6220 T6221 advmod Also,reported
R3542 T6222 T6221 punct ", ",reported
R3543 T6223 T6221 advmod similarly,reported
R3544 T6224 T6221 prep in,reported
R3545 T6225 T6224 pobj rhodopsin,in
R3546 T6226 T6225 punct (,rhodopsin
R3547 T6227 T6225 appos Rho,rhodopsin
R3548 T6228 T6225 punct ),rhodopsin
R3549 T6229 T6225 cc and,rhodopsin
R3550 T6230 T6231 amod cyclic,channel
R3551 T6231 T6235 nmod channel,alpha
R3552 T6232 T6233 npadvmod nucleotide,gated
R3553 T6233 T6231 amod gated,channel
R3554 T6234 T6233 punct -,gated
R3555 T6235 T6237 nmod alpha,mice
R3556 T6236 T6235 punct ", ",alpha
R3557 T6237 T6225 conj mice,rhodopsin
R3558 T6238 T6235 punct -,alpha
R3559 T6239 T6235 nummod 3,alpha
R3560 T6240 T6235 punct (,alpha
R3561 T6241 T6235 appos CNGA3,alpha
R3562 T6242 T6237 punct ),mice
R3563 T6243 T6244 amod double,knockout
R3564 T6244 T6237 compound knockout,mice
R3565 T6245 T6237 punct (,mice
R3566 T6246 T6237 appos Rho,mice
R3567 T6247 T6246 punct -,Rho
R3568 T6248 T6246 punct /,Rho
R3569 T6249 T6246 punct -,Rho
R3570 T6250 T6246 punct ", ",Rho
R3571 T6251 T6246 appos CNGA3,Rho
R3572 T6252 T6251 punct -,CNGA3
R3573 T6253 T6251 punct /,CNGA3
R3574 T6254 T6251 punct -,CNGA3
R3575 T6255 T6221 punct ),reported
R3576 T6256 T6221 punct ", ",reported
R3577 T6257 T6221 nsubjpass synapses,reported
R3578 T6258 T6221 auxpass are,reported
R3579 T6259 T6260 aux to,form
R3580 T6260 T6221 xcomp form,reported
R3581 T6261 T6260 advmod normally,form
R3582 T6262 T6263 punct [,49
R3583 T6263 T6221 parataxis 49,reported
R3584 T6264 T6263 punct ],49
R3585 T6265 T6221 punct .,reported
R3586 T6267 T6268 det These,observations
R3587 T6268 T6269 nsubj observations,demonstrate
R3588 T6270 T6271 mark that,occur
R3589 T6271 T6269 ccomp occur,demonstrate
R3590 T6272 T6273 compound photoreceptor,synaptogenesis
R3591 T6273 T6271 nsubj synaptogenesis,occur
R3592 T6274 T6271 aux can,occur
R3593 T6275 T6271 prep in,occur
R3594 T6276 T6277 det the,absence
R3595 T6277 T6275 pobj absence,in
R3596 T6278 T6277 prep of,absence
R3597 T6279 T6280 amod outer,segment
R3598 T6280 T6281 compound segment,formation
R3599 T6281 T6278 pobj formation,of
R3600 T6282 T6269 punct .,demonstrate
R3601 T6284 T6285 prep In,is
R3602 T6286 T6284 pcomp keeping,In
R3603 T6287 T6286 prep with,keeping
R3604 T6288 T6289 det this,observation
R3605 T6289 T6287 pobj observation,with
R3606 T6290 T6291 det the,fact
R3607 T6291 T6285 nsubj fact,is
R3608 T6292 T6293 mark that,is
R3609 T6293 T6291 acl is,fact
R3610 T6294 T6295 det some,activity
R3611 T6295 T6293 nsubj activity,is
R3612 T6296 T6295 compound electroretinogram,activity
R3613 T6297 T6293 acomp present,is
R3614 T6298 T6293 prep in,is
R3615 T6299 T6300 nmod peripherin,mice
R3616 T6300 T6298 pobj mice,in
R3617 T6301 T6299 punct -,peripherin
R3618 T6302 T6299 punct /,peripherin
R3619 T6303 T6299 punct -,peripherin
R3620 T6304 T6293 punct ", ",is
R3621 T6305 T6293 advcl suggesting,is
R3622 T6306 T6307 mark that,is
R3623 T6307 T6305 ccomp is,suggesting
R3624 T6308 T6309 amod minimal,phototransduction
R3625 T6309 T6307 nsubj phototransduction,is
R3626 T6310 T6307 acomp present,is
R3627 T6311 T6307 prep in,is
R3628 T6312 T6313 det these,mice
R3629 T6313 T6311 pobj mice,in
R3630 T6314 T6307 punct ", ",is
R3631 T6315 T6307 advmod enough,is
R3632 T6316 T6317 aux to,drive
R3633 T6317 T6315 xcomp drive,enough
R3634 T6318 T6317 dobj activity,drive
R3635 T6319 T6317 prep at,drive
R3636 T6320 T6321 det the,synapse
R3637 T6321 T6319 pobj synapse,at
R3638 T6322 T6321 compound photoreceptor,synapse
R3639 T6323 T6285 punct .,is
R3640 T6325 T6326 advmod In,vitro
R3641 T6326 T6327 amod vitro,studies
R3642 T6327 T6328 nsubj studies,indicated
R3643 T6329 T6330 prep wherein,formed
R3644 T6330 T6327 relcl formed,studies
R3645 T6331 T6332 compound synapse,elements
R3646 T6332 T6330 nsubjpass elements,formed
R3647 T6333 T6330 auxpass are,formed
R3648 T6334 T6330 prep in,formed
R3649 T6335 T6336 det the,absence
R3650 T6336 T6334 pobj absence,in
R3651 T6337 T6336 prep of,absence
R3652 T6338 T6339 amod proper,development
R3653 T6339 T6337 pobj development,of
R3654 T6340 T6341 amod outer,segment
R3655 T6341 T6339 compound segment,development
R3656 T6342 T6336 cc and,absence
R3657 T6343 T6336 punct ", ",absence
R3658 T6344 T6345 advmod therefore,absence
R3659 T6345 T6336 conj absence,absence
R3660 T6346 T6345 punct ", ",absence
R3661 T6347 T6345 amod possible,absence
R3662 T6348 T6345 prep of,absence
R3663 T6349 T6350 npadvmod light,dependent
R3664 T6350 T6352 amod dependent,activity
R3665 T6351 T6350 punct -,dependent
R3666 T6352 T6348 pobj activity,of
R3667 T6353 T6352 compound photoreceptor,activity
R3668 T6354 T6328 punct ", ",indicated
R3669 T6355 T6328 aux have,indicated
R3670 T6356 T6357 det the,independence
R3671 T6357 T6328 dobj independence,indicated
R3672 T6358 T6357 prep of,independence
R3673 T6359 T6358 pobj phototransduction,of
R3674 T6360 T6359 cc and,phototransduction
R3675 T6361 T6362 compound synapse,formation
R3676 T6362 T6359 conj formation,phototransduction
R3677 T6363 T6328 punct ", ",indicated
R3678 T6364 T6365 advmod at,least
R3679 T6365 T6366 advmod least,for
R3680 T6366 T6328 prep for,indicated
R3681 T6367 T6368 det the,stages
R3682 T6368 T6366 pobj stages,for
R3683 T6369 T6368 amod initial,stages
R3684 T6370 T6371 punct [,51
R3685 T6371 T6328 parataxis 51,indicated
R3686 T6372 T6371 nummod 50,51
R3687 T6373 T6371 punct ",",51
R3688 T6374 T6371 punct ],51
R3689 T6375 T6328 punct .,indicated
R3690 T6377 T6378 det These,data
R3691 T6378 T6379 nsubj data,suggest
R3692 T6380 T6379 advmod then,suggest
R3693 T6381 T6382 mark that,is
R3694 T6382 T6379 ccomp is,suggest
R3695 T6383 T6384 det the,fact
R3696 T6384 T6382 nsubj fact,is
R3697 T6385 T6386 mark that,have
R3698 T6386 T6384 acl have,fact
R3699 T6387 T6388 det the,photoreceptors
R3700 T6388 T6386 nsubj photoreceptors,have
R3701 T6389 T6388 nmod Crx,photoreceptors
R3702 T6390 T6389 punct -,Crx
R3703 T6391 T6389 punct /,Crx
R3704 T6392 T6389 punct -,Crx
R3705 T6393 T6386 aux do,have
R3706 T6394 T6386 neg not,have
R3707 T6395 T6396 amod proper,endings
R3708 T6396 T6386 dobj endings,have
R3709 T6397 T6396 amod synaptic,endings
R3710 T6398 T6382 neg not,is
R3711 T6399 T6382 prep due,is
R3712 T6400 T6399 pcomp to,due
R3713 T6401 T6402 det a,lack
R3714 T6402 T6399 pobj lack,due
R3715 T6403 T6402 prep of,lack
R3716 T6404 T6405 amod outer,segment
R3717 T6405 T6406 compound segment,formation
R3718 T6406 T6403 pobj formation,of
R3719 T6407 T6379 punct .,suggest
R3720 T6409 T6410 det A,explanation
R3721 T6410 T6413 nsubj explanation,is
R3722 T6411 T6412 advmod more,likely
R3723 T6412 T6410 amod likely,explanation
R3724 T6414 T6415 mark that,plays
R3725 T6415 T6413 ccomp plays,is
R3726 T6416 T6415 nsubj Crx,plays
R3727 T6417 T6418 det a,role
R3728 T6418 T6415 dobj role,plays
R3729 T6419 T6415 prep in,plays
R3730 T6420 T6421 compound photoreceptor,synapse
R3731 T6421 T6422 compound synapse,formation
R3732 T6422 T6419 pobj formation,in
R3733 T6423 T6415 punct ", ",plays
R3734 T6424 T6425 advmod perhaps,by
R3735 T6425 T6415 prep by,plays
R3736 T6426 T6425 pcomp regulating,by
R3737 T6427 T6426 advmod directly,regulating
R3738 T6428 T6427 punct ", ",directly
R3739 T6429 T6427 cc or,directly
R3740 T6430 T6427 conj indirectly,directly
R3741 T6431 T6426 punct ", ",regulating
R3742 T6432 T6433 amod important,genes
R3743 T6433 T6426 dobj genes,regulating
R3744 T6434 T6433 prep in,genes
R3745 T6435 T6436 det this,process
R3746 T6436 T6434 pobj process,in
R3747 T6437 T6413 punct .,is
R3748 T6439 T6440 advcl Using,examined
R3749 T6441 T6439 dobj immunohistochemistry,Using
R3750 T6442 T6440 punct ", ",examined
R3751 T6443 T6440 nsubj we,examined
R3752 T6444 T6445 det the,expression
R3753 T6445 T6440 dobj expression,examined
R3754 T6446 T6440 prep of,examined
R3755 T6447 T6448 amod common,proteins
R3756 T6448 T6446 pobj proteins,of
R3757 T6449 T6448 amod pre-synaptic,proteins
R3758 T6450 T6448 amod terminal,proteins
R3759 T6451 T6448 punct ", ",proteins
R3760 T6452 T6448 prep including,proteins
R3761 T6453 T6452 pobj KIF3a,including
R3762 T6454 T6453 punct ", ",KIF3a
R3763 T6455 T6453 conj SV2,KIF3a
R3764 T6456 T6455 punct ", ",SV2
R3765 T6457 T6455 cc and,SV2
R3766 T6458 T6455 conj synaptophysin,SV2
R3767 T6459 T6440 punct ", ",examined
R3768 T6460 T6440 cc and,examined
R3769 T6461 T6440 conj were,examined
R3770 T6462 T6461 acomp unable,were
R3771 T6463 T6464 aux to,observe
R3772 T6464 T6462 xcomp observe,unable
R3773 T6465 T6466 amod qualitative,differences
R3774 T6466 T6464 dobj differences,observe
R3775 T6467 T6466 prep between,differences
R3776 T6468 T6469 nmod Crx,tissue
R3777 T6469 T6467 pobj tissue,between
R3778 T6470 T6468 punct -,Crx
R3779 T6471 T6468 punct /,Crx
R3780 T6472 T6468 punct -,Crx
R3781 T6473 T6468 cc and,Crx
R3782 T6474 T6468 conj control,Crx
R3783 T6475 T6464 prep at,observe
R3784 T6476 T6475 pobj P14,at
R3785 T6477 T6478 punct (,shown
R3786 T6478 T6464 parataxis shown,observe
R3787 T6479 T6478 nsubj data,shown
R3788 T6480 T6478 neg not,shown
R3789 T6481 T6478 punct ),shown
R3790 T6482 T6440 punct .,examined
R3791 T6484 T6485 nsubj Examination,showed
R3792 T6486 T6484 prep of,Examination
R3793 T6487 T6488 poss their,levels
R3794 T6488 T6486 pobj levels,of
R3795 T6489 T6488 compound RNA,levels
R3796 T6490 T6484 prep by,Examination
R3797 T6491 T6490 pobj SAGE,by
R3798 T6492 T6493 det no,difference
R3799 T6493 T6485 dobj difference,showed
R3800 T6494 T6493 amod significant,difference
R3801 T6495 T6485 prep for,showed
R3802 T6496 T6497 det all,genes
R3803 T6497 T6495 pobj genes,for
R3804 T6498 T6497 nummod 3,genes
R3805 T6499 T6485 punct ", ",showed
R3806 T6500 T6501 mark though,recovered
R3807 T6501 T6485 advcl recovered,showed
R3808 T6502 T6503 advmod very,few
R3809 T6503 T6504 amod few,tags
R3810 T6504 T6501 nsubjpass tags,recovered
R3811 T6505 T6501 auxpass were,recovered
R3812 T6506 T6501 prep from,recovered
R3813 T6507 T6508 det these,genes
R3814 T6508 T6506 pobj genes,from
R3815 T6509 T6501 cc and,recovered
R3816 T6510 T6511 advmod thus,be
R3817 T6511 T6501 conj be,recovered
R3818 T6512 T6513 det the,analysis
R3819 T6513 T6511 nsubj analysis,be
R3820 T6514 T6513 prep of,analysis
R3821 T6515 T6516 compound RNA,levels
R3822 T6516 T6514 pobj levels,of
R3823 T6517 T6511 aux may,be
R3824 T6518 T6511 neg not,be
R3825 T6519 T6511 acomp significant,be
R3826 T6520 T6521 punct [,35
R3827 T6521 T6511 parataxis 35,be
R3828 T6522 T6521 punct ],35
R3829 T6523 T6485 punct .,showed
R3830 T6525 T6526 advmod However,are
R3831 T6527 T6526 punct ", ",are
R3832 T6528 T6529 mark since,altered
R3833 T6529 T6526 advcl altered,are
R3834 T6530 T6531 amod other,genes
R3835 T6531 T6529 nsubjpass genes,altered
R3836 T6532 T6531 acl expressed,genes
R3837 T6533 T6532 prep in,expressed
R3838 T6534 T6533 pobj photoreceptors,in
R3839 T6535 T6529 auxpass were,altered
R3840 T6536 T6529 advmod significantly,altered
R3841 T6537 T6529 prep in,altered
R3842 T6538 T6539 poss their,level
R3843 T6539 T6537 pobj level,in
R3844 T6540 T6539 compound expression,level
R3845 T6541 T6529 prep in,altered
R3846 T6542 T6543 det the,mouse
R3847 T6543 T6541 pobj mouse,in
R3848 T6544 T6543 nmod Crx,mouse
R3849 T6545 T6544 punct -,Crx
R3850 T6546 T6544 punct /,Crx
R3851 T6547 T6544 punct -,Crx
R3852 T6548 T6526 punct ", ",are
R3853 T6549 T6526 expl there,are
R3854 T6550 T6551 amod many,candidates
R3855 T6551 T6526 attr candidates,are
R3856 T6552 T6553 dep that,be
R3857 T6553 T6551 relcl be,candidates
R3858 T6554 T6553 aux could,be
R3859 T6555 T6553 acomp important,be
R3860 T6556 T6555 prep for,important
R3861 T6557 T6558 compound photoreceptor,morphogenesis
R3862 T6558 T6556 pobj morphogenesis,for
R3863 T6559 T6526 punct .,are
R3864 T6561 T6562 nsubjpass Tags,found
R3865 T6563 T6561 prep from,Tags
R3866 T6564 T6565 nummod three,genes
R3867 T6565 T6563 pobj genes,from
R3868 T6566 T6565 prep from,genes
R3869 T6567 T6566 pobj proteins,from
R3870 T6568 T6567 acl expressed,proteins
R3871 T6569 T6568 prep in,expressed
R3872 T6570 T6571 compound photoreceptor,terminals
R3873 T6571 T6569 pobj terminals,in
R3874 T6572 T6562 auxpass were,found
R3875 T6573 T6574 aux to,decreased
R3876 T6574 T6562 xcomp decreased,found
R3877 T6575 T6574 auxpass be,decreased
R3878 T6576 T6574 prep in,decreased
R3879 T6577 T6578 det a,fashion
R3880 T6578 T6576 pobj fashion,in
R3881 T6579 T6580 advmod statistically,significant
R3882 T6580 T6578 amod significant,fashion
R3883 T6581 T6562 punct ", ",found
R3884 T6582 T6583 advmod namely,substrate
R3885 T6583 T6562 dobj substrate,found
R3886 T6584 T6583 det the,substrate
R3887 T6585 T6586 npadvmod HGF,regulated
R3888 T6586 T6583 amod regulated,substrate
R3889 T6587 T6586 punct -,regulated
R3890 T6588 T6589 compound tyrosine,kinase
R3891 T6589 T6583 compound kinase,substrate
R3892 T6590 T6583 punct ", ",substrate
R3893 T6591 T6592 det the,protein
R3894 T6592 T6583 conj protein,substrate
R3895 T6593 T6592 compound CRIPT,protein
R3896 T6594 T6592 punct ", ",protein
R3897 T6595 T6592 cc and,protein
R3898 T6596 T6592 conj synaptotagmin,protein
R3899 T6597 T6596 nummod 1,synaptotagmin
R3900 T6598 T6599 punct (,Blackshaw
R3901 T6599 T6562 meta Blackshaw,found
R3902 T6600 T6599 cc and,Blackshaw
R3903 T6601 T6599 conj Cepko,Blackshaw
R3904 T6602 T6601 punct ", ",Cepko
R3905 T6603 T6604 amod unpublished,data
R3906 T6604 T6601 conj data,Cepko
R3907 T6605 T6604 punct ),data
R3908 T6606 T6562 punct .,found
R3909 T6608 T6609 det An,example
R3910 T6609 T6610 nsubj example,is
R3911 T6611 T6609 prep of,example
R3912 T6612 T6613 det a,gene
R3913 T6613 T6611 pobj gene,of
R3914 T6614 T6615 dep that,increased
R3915 T6615 T6613 relcl increased,gene
R3916 T6616 T6615 auxpass was,increased
R3917 T6617 T6615 prep in,increased
R3918 T6618 T6619 det the,retina
R3919 T6619 T6617 pobj retina,in
R3920 T6620 T6619 nmod Crx,retina
R3921 T6621 T6620 punct -,Crx
R3922 T6622 T6620 punct /,Crx
R3923 T6623 T6620 punct -,Crx
R3924 T6624 T6610 attr HRG4,is
R3925 T6625 T6624 punct (,HRG4
R3926 T6626 T6627 det a,homologue
R3927 T6627 T6624 appos homologue,HRG4
R3928 T6628 T6627 prep of,homologue
R3929 T6629 T6630 det the,gene
R3930 T6630 T6628 pobj gene,of
R3931 T6631 T6632 compound C.,elegans
R3932 T6632 T6630 compound elegans,gene
R3933 T6633 T6630 compound Unc119,gene
R3934 T6634 T6624 punct ),HRG4
R3935 T6635 T6636 punct (,Blackshaw
R3936 T6636 T6624 meta Blackshaw,HRG4
R3937 T6637 T6636 cc and,Blackshaw
R3938 T6638 T6636 conj Cepko,Blackshaw
R3939 T6639 T6638 punct ", ",Cepko
R3940 T6640 T6641 amod unpublished,data
R3941 T6641 T6638 conj data,Cepko
R3942 T6642 T6641 punct ),data
R3943 T6643 T6644 dep which,encodes
R3944 T6644 T6624 relcl encodes,HRG4
R3945 T6645 T6646 det a,component
R3946 T6646 T6644 dobj component,encodes
R3947 T6647 T6646 prep of,component
R3948 T6648 T6649 det the,synapse
R3949 T6649 T6647 pobj synapse,of
R3950 T6650 T6649 compound ribbon,synapse
R3951 T6651 T6652 punct [,33
R3952 T6652 T6610 parataxis 33,is
R3953 T6653 T6652 punct ],33
R3954 T6654 T6610 punct .,is
R3955 T6656 T6657 det The,fact
R3956 T6657 T6658 nsubj fact,indicate
R3957 T6659 T6660 mark that,upregulated
R3958 T6660 T6657 acl upregulated,fact
R3959 T6661 T6660 nsubjpass it,upregulated
R3960 T6662 T6660 auxpass is,upregulated
R3961 T6663 T6658 aux might,indicate
R3962 T6664 T6665 det a,response
R3963 T6665 T6658 dobj response,indicate
R3964 T6666 T6665 prep to,response
R3965 T6667 T6668 det the,lack
R3966 T6668 T6666 pobj lack,to
R3967 T6669 T6668 prep of,lack
R3968 T6670 T6671 amod proper,structures
R3969 T6671 T6669 pobj structures,of
R3970 T6672 T6671 amod terminal,structures
R3971 T6673 T6658 punct .,indicate
R3972 T6675 T6676 amod Several,genes
R3973 T6676 T6678 nsubj genes,increased
R3974 T6677 T6676 amod other,genes
R3975 T6679 T6676 acl encoding,genes
R3976 T6680 T6681 amod putative,elements
R3977 T6681 T6679 dobj elements,encoding
R3978 T6682 T6681 amod cytoskeletal,elements
R3979 T6683 T6678 advmod also,increased
R3980 T6684 T6678 aux were,increased
R3981 T6685 T6686 punct (,protein
R3982 T6686 T6678 parataxis protein,increased
R3983 T6687 T6686 advmod e.g.,protein
R3984 T6688 T6689 npadvmod microtubule,associated
R3985 T6689 T6686 amod associated,protein
R3986 T6690 T6686 nummod 4,protein
R3987 T6691 T6686 punct ),protein
R3988 T6692 T6678 cc or,increased
R3989 T6693 T6678 conj decreased,increased
R3990 T6694 T6695 punct (,cofilin
R3991 T6695 T6693 parataxis cofilin,decreased
R3992 T6696 T6695 advmod e.g.,cofilin
R3993 T6697 T6695 nummod 1,cofilin
R3994 T6698 T6695 punct ),cofilin
R3995 T6699 T6678 prep in,increased
R3996 T6700 T6701 det the,retina
R3997 T6701 T6699 pobj retina,in
R3998 T6702 T6701 nmod Crx,retina
R3999 T6703 T6702 punct -,Crx
R4000 T6704 T6702 punct /,Crx
R4001 T6705 T6702 punct -,Crx
R4002 T6706 T6678 punct ", ",increased
R4003 T6707 T6678 prep with,increased
R4004 T6708 T6709 compound P,values
R4005 T6709 T6707 pobj values,with
R4006 T6710 T6709 prep of,values
R4007 T6711 T6712 punct <,.005
R4008 T6712 T6710 pobj .005,of
R4009 T6713 T6678 punct .,increased
R4010 T6715 T6716 nsubjpass It,known
R4011 T6717 T6716 auxpass is,known
R4012 T6718 T6716 neg not,known
R4013 T6719 T6720 mark whether,involved
R4014 T6720 T6716 ccomp involved,known
R4015 T6721 T6720 nsubjpass any,involved
R4016 T6722 T6721 prep of,any
R4017 T6723 T6724 det these,genes
R4018 T6724 T6722 pobj genes,of
R4019 T6725 T6720 auxpass are,involved
R4020 T6726 T6720 prep in,involved
R4021 T6727 T6726 pcomp building,in
R4022 T6728 T6727 cc or,building
R4023 T6729 T6727 conj regulating,building
R4024 T6730 T6731 amod synaptic,structures
R4025 T6731 T6729 dobj structures,regulating
R4026 T6732 T6716 punct ", ",known
R4027 T6733 T6716 cc but,known
R4028 T6734 T6735 nsubj they,are
R4029 T6735 T6716 conj are,known
R4030 T6736 T6735 advmod now,are
R4031 T6737 T6735 attr genes,are
R4032 T6738 T6739 dep that,lead
R4033 T6739 T6737 relcl lead,genes
R4034 T6740 T6739 aux might,lead
R4035 T6741 T6739 prep to,lead
R4036 T6742 T6743 det a,understanding
R4037 T6743 T6741 pobj understanding,to
R4038 T6744 T6743 amod better,understanding
R4039 T6745 T6743 prep of,understanding
R4040 T6746 T6747 det the,construction
R4041 T6747 T6745 pobj construction,of
R4042 T6748 T6747 cc and,construction
R4043 T6749 T6747 conj function,construction
R4044 T6750 T6747 prep of,construction
R4045 T6751 T6752 det the,structure
R4046 T6752 T6750 pobj structure,of
R4047 T6753 T6754 advmod relatively,unique
R4048 T6754 T6752 amod unique,structure
R4049 T6755 T6752 prep of,structure
R4050 T6756 T6757 det the,synapse
R4051 T6757 T6755 pobj synapse,of
R4052 T6758 T6757 compound ribbon,synapse
R4053 T6759 T6735 punct .,are
R4054 T6761 T6762 amod Abnormal,formation
R4055 T6762 T6765 nsubjpass formation,noted
R4056 T6763 T6764 compound photoreceptor,terminal
R4057 T6764 T6762 compound terminal,formation
R4058 T6766 T6765 auxpass was,noted
R4059 T6767 T6765 prep in,noted
R4060 T6768 T6769 det a,study
R4061 T6769 T6767 pobj study,in
R4062 T6770 T6771 dep that,examined
R4063 T6771 T6769 relcl examined,study
R4064 T6772 T6773 amod retinal,development
R4065 T6773 T6771 dobj development,examined
R4066 T6774 T6771 prep in,examined
R4067 T6775 T6776 det the,mouse
R4068 T6776 T6774 pobj mouse,in
R4069 T6777 T6778 compound laminin,chain
R4070 T6778 T6780 npadvmod chain,deficient
R4071 T6779 T6778 compound beta2,chain
R4072 T6780 T6776 amod deficient,mouse
R4073 T6781 T6780 punct -,deficient
R4074 T6782 T6783 punct [,52
R4075 T6783 T6765 parataxis 52,noted
R4076 T6784 T6783 punct ],52
R4077 T6785 T6765 punct .,noted
R4078 T6787 T6788 amod Several,pathologies
R4079 T6788 T6789 nsubjpass pathologies,noted
R4080 T6790 T6789 auxpass were,noted
R4081 T6791 T6789 prep in,noted
R4082 T6792 T6793 det these,mice
R4083 T6793 T6791 pobj mice,in
R4084 T6794 T6789 punct .,noted
R4085 T6796 T6797 advmod First,displayed
R4086 T6797 T6805 ccomp displayed,reduced
R4087 T6798 T6797 punct ", ",displayed
R4088 T6799 T6800 compound laminin,chain
R4089 T6800 T6802 npadvmod chain,deficient
R4090 T6801 T6800 compound beta2,chain
R4091 T6802 T6804 amod deficient,mice
R4092 T6803 T6802 punct -,deficient
R4093 T6804 T6797 nsubj mice,displayed
R4094 T6806 T6807 amod abnormal,elongation
R4095 T6807 T6797 dobj elongation,displayed
R4096 T6808 T6809 amod outer,segment
R4097 T6809 T6807 compound segment,elongation
R4098 T6810 T6807 punct ", ",elongation
R4099 T6811 T6807 cc but,elongation
R4100 T6812 T6813 det a,phenotype
R4101 T6813 T6807 conj phenotype,elongation
R4102 T6814 T6815 advmod more,mild
R4103 T6815 T6813 nmod mild,phenotype
R4104 T6816 T6813 prep than,phenotype
R4105 T6817 T6816 pobj that,than
R4106 T6818 T6817 prep of,that
R4107 T6819 T6820 det the,mice
R4108 T6820 T6818 pobj mice,of
R4109 T6821 T6820 nmod Crx,mice
R4110 T6822 T6821 punct -,Crx
R4111 T6823 T6821 punct /,Crx
R4112 T6824 T6821 punct -,Crx
R4113 T6825 T6805 punct ;,reduced
R4114 T6826 T6827 det the,segments
R4115 T6827 T6805 nsubjpass segments,reduced
R4116 T6828 T6827 amod outer,segments
R4117 T6829 T6805 auxpass were,reduced
R4118 T6830 T6805 prep by,reduced
R4119 T6831 T6832 nummod 50,%
R4120 T6832 T6830 pobj %,by
R4121 T6833 T6805 prep in,reduced
R4122 T6834 T6833 pobj length,in
R4123 T6835 T6805 punct .,reduced
R4124 T6837 T6838 advmod Also,perturbed
R4125 T6839 T6840 compound photoreceptor,terminals
R4126 T6840 T6838 nsubjpass terminals,perturbed
R4127 T6841 T6838 auxpass were,perturbed
R4128 T6842 T6838 prep in,perturbed
R4129 T6843 T6844 compound laminin,beta2
R4130 T6844 T6845 compound beta2,mutants
R4131 T6845 T6842 pobj mutants,in
R4132 T6846 T6838 punct ", ",perturbed
R4133 T6847 T6838 cc but,perturbed
R4134 T6848 T6849 advmod again,was
R4135 T6849 T6838 conj was,perturbed
R4136 T6850 T6851 det the,phenotype
R4137 T6851 T6849 nsubj phenotype,was
R4138 T6852 T6853 advmod more,subtle
R4139 T6853 T6849 acomp subtle,was
R4140 T6854 T6853 prep then,subtle
R4141 T6855 T6854 pobj that,then
R4142 T6856 T6855 prep of,that
R4143 T6857 T6858 nmod Crx,mice
R4144 T6858 T6856 pobj mice,of
R4145 T6859 T6857 punct -,Crx
R4146 T6860 T6857 punct /,Crx
R4147 T6861 T6857 punct -,Crx
R4148 T6862 T6849 punct .,was
R4149 T6864 T6865 det The,layer
R4150 T6865 T6868 nsubj layer,demonstrated
R4151 T6866 T6867 amod outer,plexiform
R4152 T6867 T6865 compound plexiform,layer
R4153 T6869 T6865 prep of,layer
R4154 T6870 T6871 det the,retinas
R4155 T6871 T6869 pobj retinas,of
R4156 T6872 T6873 npadvmod beta2,deficient
R4157 T6873 T6871 amod deficient,retinas
R4158 T6874 T6873 punct -,deficient
R4159 T6875 T6876 advmod only,7
R4160 T6876 T6877 nummod 7,%
R4161 T6877 T6878 nmod %,synapses
R4162 T6878 T6868 dobj synapses,demonstrated
R4163 T6879 T6878 amod normal,synapses
R4164 T6880 T6878 amod invaginating,synapses
R4165 T6881 T6868 punct ", ",demonstrated
R4166 T6882 T6883 mark while,had
R4167 T6883 T6868 advcl had,demonstrated
R4168 T6884 T6885 det the,remainder
R4169 T6885 T6883 nsubj remainder,had
R4170 T6886 T6887 amod various,pathologies
R4171 T6887 T6883 dobj pathologies,had
R4172 T6888 T6887 punct ", ",pathologies
R4173 T6889 T6887 prep including,pathologies
R4174 T6890 T6891 amod floating,ribbons
R4175 T6891 T6889 pobj ribbons,including
R4176 T6892 T6891 amod synaptic,ribbons
R4177 T6893 T6883 punct ", ",had
R4178 T6894 T6895 mark as,seen
R4179 T6895 T6883 advcl seen,had
R4180 T6896 T6895 advmod here,seen
R4181 T6897 T6868 punct .,demonstrated
R4182 T6899 T6900 det The,relationship
R4183 T6900 T6902 nsubj relationship,is
R4184 T6901 T6900 amod mechanistic,relationship
R4185 T6903 T6900 prep of,relationship
R4186 T6904 T6905 det these,molecules
R4187 T6905 T6903 pobj molecules,of
R4188 T6906 T6905 nummod two,molecules
R4189 T6907 T6908 punct ", ",any
R4190 T6908 T6900 parataxis any,relationship
R4191 T6909 T6908 mark if,any
R4192 T6910 T6908 punct ", ",any
R4193 T6911 T6900 prep in,relationship
R4194 T6912 T6913 compound photoreceptor,morphogenesis
R4195 T6913 T6911 pobj morphogenesis,in
R4196 T6914 T6902 acomp unknown,is
R4197 T6915 T6902 prep to,is
R4198 T6916 T6915 pobj date,to
R4199 T6917 T6902 punct .,is
R4200 T6919 T6920 det The,mRNA
R4201 T6920 T6921 nsubjpass mRNA,detected
R4202 T6922 T6920 prep for,mRNA
R4203 T6923 T6924 compound laminin,beta2
R4204 T6924 T6922 pobj beta2,for
R4205 T6925 T6921 auxpass was,detected
R4206 T6926 T6921 neg not,detected
R4207 T6927 T6921 prep in,detected
R4208 T6928 T6929 det the,study
R4209 T6929 T6927 pobj study,in
R4210 T6930 T6929 compound SAGE,study
R4211 T6931 T6929 prep of,study
R4212 T6932 T6933 det the,levels
R4213 T6933 T6931 pobj levels,of
R4214 T6934 T6933 amod relative,levels
R4215 T6935 T6933 compound RNA,levels
R4216 T6936 T6933 prep in,levels
R4217 T6937 T6936 pobj Crx,in
R4218 T6938 T6937 punct -,Crx
R4219 T6939 T6937 punct /,Crx
R4220 T6940 T6937 punct -,Crx
R4221 T6941 T6937 cc and,Crx
R4222 T6942 T6937 conj Crx,Crx
R4223 T6943 T6942 punct +,Crx
R4224 T6944 T6942 punct /,Crx
R4225 T6945 T6942 punct +,Crx
R4226 T6946 T6921 cc and,detected
R4227 T6947 T6948 advmod thus,comment
R4228 T6948 T6921 conj comment,detected
R4229 T6949 T6948 nsubj we,comment
R4230 T6950 T6948 aux can,comment
R4231 T6951 T6948 neg not,comment
R4232 T6952 T6948 prep on,comment
R4233 T6953 T6954 mark whether,altered
R4234 T6954 T6952 pcomp altered,on
R4235 T6955 T6956 det the,levels
R4236 T6956 T6954 nsubjpass levels,altered
R4237 T6957 T6956 prep of,levels
R4238 T6958 T6957 pobj RNA,of
R4239 T6959 T6956 prep for,levels
R4240 T6960 T6961 compound laminin,beta2
R4241 T6961 T6959 pobj beta2,for
R4242 T6962 T6954 auxpass were,altered
R4243 T6963 T6948 punct .,comment
R4246 T7157 T7158 nmod Crx,mice
R4247 T7158 T7162 nsubj mice,are
R4248 T7159 T7157 punct -,Crx
R4249 T7160 T7157 punct /,Crx
R4250 T7161 T7157 punct -,Crx
R4251 T7163 T7164 det a,model
R4252 T7164 T7162 attr model,are
R4253 T7165 T7164 prep for,model
R4254 T7166 T7165 pobj LCA,for
R4255 T7168 T7169 nsubjpass Crx,implicated
R4256 T7170 T7169 aux has,implicated
R4257 T7171 T7169 auxpass been,implicated
R4258 T7172 T7169 prep in,implicated
R4259 T7173 T7174 nummod three,diseases
R4260 T7174 T7172 pobj diseases,in
R4261 T7175 T7174 compound photoreceptor,diseases
R4262 T7176 T7177 dep that,result
R4263 T7177 T7174 relcl result,diseases
R4264 T7178 T7177 prep in,result
R4265 T7179 T7180 amod human,blindness
R4266 T7180 T7178 pobj blindness,in
R4267 T7181 T7180 punct ", ",blindness
R4268 T7182 T7183 compound cone,rod
R4269 T7183 T7185 compound rod,dystrophy2
R4270 T7184 T7183 punct -,rod
R4271 T7185 T7180 conj dystrophy2,blindness
R4272 T7186 T7185 punct ", ",dystrophy2
R4273 T7187 T7188 poss Leber,amaurosis
R4274 T7188 T7185 conj amaurosis,dystrophy2
R4275 T7189 T7187 case 's,Leber
R4276 T7190 T7188 amod congenital,amaurosis
R4277 T7191 T7188 punct ", ",amaurosis
R4278 T7192 T7188 cc and,amaurosis
R4279 T7193 T7194 compound retinitis,pigmentosa
R4280 T7194 T7188 conj pigmentosa,amaurosis
R4281 T7195 T7196 punct (,see
R4282 T7196 T7169 parataxis see,implicated
R4283 T7197 T7196 prep for,see
R4284 T7198 T7197 pobj review,for
R4285 T7199 T7196 punct ", ",see
R4286 T7200 T7196 punct [,see
R4287 T7201 T7196 dobj 53,see
R4288 T7202 T7196 punct ],see
R4289 T7203 T7196 punct ),see
R4290 T7204 T7169 punct .,implicated
R4291 T7206 T7207 det The,dystrophies
R4292 T7207 T7211 nsubjpass dystrophies,characterized
R4293 T7208 T7209 compound cone,rod
R4294 T7209 T7207 compound rod,dystrophies
R4295 T7210 T7209 punct -,rod
R4296 T7212 T7207 punct (,dystrophies
R4297 T7213 T7207 appos CRDs,dystrophies
R4298 T7214 T7207 punct ),dystrophies
R4299 T7215 T7211 auxpass are,characterized
R4300 T7216 T7211 agent by,characterized
R4301 T7217 T7216 pobj loss,by
R4302 T7218 T7217 prep of,loss
R4303 T7219 T7220 npadvmod cone,mediated
R4304 T7220 T7222 amod mediated,vision
R4305 T7221 T7220 punct -,mediated
R4306 T7222 T7218 pobj vision,of
R4307 T7223 T7211 prep in,characterized
R4308 T7224 T7225 det the,decade
R4309 T7225 T7223 pobj decade,in
R4310 T7226 T7225 amod first,decade
R4311 T7227 T7225 prep of,decade
R4312 T7228 T7227 pobj life,of
R4313 T7229 T7211 cc or,characterized
R4314 T7230 T7231 advmod later,with
R4315 T7231 T7211 conj with,characterized
R4316 T7232 T7231 punct ", ",with
R4317 T7233 T7234 amod concomitant,loss
R4318 T7234 T7231 pobj loss,with
R4319 T7235 T7233 cc or,concomitant
R4320 T7236 T7233 conj subsequent,concomitant
R4321 T7237 T7234 prep of,loss
R4322 T7238 T7239 npadvmod rod,mediated
R4323 T7239 T7241 amod mediated,vision
R4324 T7240 T7239 punct -,mediated
R4325 T7241 T7237 pobj vision,of
R4326 T7242 T7243 punct [,54
R4327 T7243 T7231 parataxis 54,with
R4328 T7244 T7243 punct ],54
R4329 T7245 T7211 punct .,characterized
R4330 T7247 T7248 advmod Conversely,is
R4331 T7249 T7248 punct ", ",is
R4332 T7250 T7248 nsubj RP,is
R4333 T7251 T7248 acomp notable,is
R4334 T7252 T7251 prep for,notable
R4335 T7253 T7254 amod initial,loss
R4336 T7254 T7252 pobj loss,for
R4337 T7255 T7254 prep of,loss
R4338 T7256 T7257 compound rod,function
R4339 T7257 T7255 pobj function,of
R4340 T7258 T7254 punct ", ",loss
R4341 T7259 T7254 acl followed,loss
R4342 T7260 T7259 agent by,followed
R4343 T7261 T7260 pobj loss,by
R4344 T7262 T7261 prep of,loss
R4345 T7263 T7264 npadvmod cone,mediated
R4346 T7264 T7266 amod mediated,vision
R4347 T7265 T7264 punct -,mediated
R4348 T7266 T7262 pobj vision,of
R4349 T7267 T7268 punct [,55
R4350 T7268 T7248 parataxis 55,is
R4351 T7269 T7268 punct ],55
R4352 T7270 T7248 punct .,is
R4353 T7272 T7273 det The,majority
R4354 T7273 T7274 nsubj majority,encode
R4355 T7275 T7273 prep of,majority
R4356 T7276 T7277 amod known,genes
R4357 T7277 T7275 pobj genes,of
R4358 T7278 T7277 amod responsible,genes
R4359 T7279 T7278 prep for,responsible
R4360 T7280 T7281 amod human,blindness
R4361 T7281 T7279 pobj blindness,for
R4362 T7282 T7281 amod genetic,blindness
R4363 T7283 T7274 punct ", ",encode
R4364 T7284 T7274 dobj proteins,encode
R4365 T7285 T7284 acl expressed,proteins
R4366 T7286 T7287 advmod almost,exclusively
R4367 T7287 T7288 advmod exclusively,in
R4368 T7288 T7285 prep in,expressed
R4369 T7289 T7287 punct ", ",exclusively
R4370 T7290 T7287 cc or,exclusively
R4371 T7291 T7287 conj exclusively,exclusively
R4372 T7292 T7288 punct ", ",in
R4373 T7293 T7288 pobj photoreceptors,in
R4374 T7294 T7293 punct ", ",photoreceptors
R4375 T7295 T7296 advmod particularly,in
R4376 T7296 T7293 prep in,photoreceptors
R4377 T7297 T7298 det the,segment
R4378 T7298 T7296 pobj segment,in
R4379 T7299 T7298 amod outer,segment
R4380 T7300 T7301 punct [,35
R4381 T7301 T7274 parataxis 35,encode
R4382 T7302 T7301 punct ],35
R4383 T7303 T7274 punct .,encode
R4384 T7305 T7306 nsubjpass Many,required
R4385 T7307 T7305 prep of,Many
R4386 T7308 T7309 det these,proteins
R4387 T7309 T7307 pobj proteins,of
R4388 T7310 T7306 auxpass are,required
R4389 T7311 T7306 prep for,required
R4390 T7312 T7311 pobj phototransduction,for
R4391 T7313 T7312 cc or,phototransduction
R4392 T7314 T7315 amod outer,segment
R4393 T7315 T7316 compound segment,structure
R4394 T7316 T7312 conj structure,phototransduction
R4395 T7317 T7306 punct .,required
R4396 T7319 T7320 det The,mechanisms
R4397 T7320 T7321 nsubj mechanisms,remain
R4398 T7322 T7323 advmod whereby,lead
R4399 T7323 T7320 relcl lead,mechanisms
R4400 T7324 T7323 nsubj mutations,lead
R4401 T7325 T7324 prep in,mutations
R4402 T7326 T7327 npadvmod rod,specific
R4403 T7327 T7329 amod specific,genes
R4404 T7328 T7327 punct -,specific
R4405 T7329 T7325 pobj genes,in
R4406 T7330 T7329 punct ", ",genes
R4407 T7331 T7332 amod such,as
R4408 T7332 T7329 prep as,genes
R4409 T7333 T7332 pobj rhodopsin,as
R4410 T7334 T7323 punct ", ",lead
R4411 T7335 T7323 advmod eventually,lead
R4412 T7336 T7323 prep to,lead
R4413 T7337 T7338 compound cone,degeneration
R4414 T7338 T7336 pobj degeneration,to
R4415 T7339 T7323 prep in,lead
R4416 T7340 T7339 pobj RP,in
R4417 T7341 T7321 acomp obscure,remain
R4418 T7342 T7321 punct .,remain
R4419 T7344 T7345 nsubj Mutations,were
R4420 T7346 T7344 prep in,Mutations
R4421 T7347 T7346 pobj Crx,in
R4422 T7348 T7349 det the,first
R4423 T7349 T7345 attr first,were
R4424 T7350 T7349 punct ", ",first
R4425 T7351 T7349 cc and,first
R4426 T7352 T7353 advmod still,one
R4427 T7353 T7354 nummod one,examples
R4428 T7354 T7349 conj examples,first
R4429 T7355 T7353 prep of,one
R4430 T7356 T7357 det a,few
R4431 T7357 T7355 pobj few,of
R4432 T7358 T7357 advmod very,few
R4433 T7359 T7349 prep of,first
R4434 T7360 T7361 det a,mutation
R4435 T7361 T7359 pobj mutation,of
R4436 T7362 T7363 compound transcription,factor
R4437 T7363 T7361 compound factor,mutation
R4438 T7364 T7361 acl leading,mutation
R4439 T7365 T7364 prep to,leading
R4440 T7366 T7367 compound photoreceptor,disease
R4441 T7367 T7365 pobj disease,to
R4442 T7368 T7345 punct .,were
R4443 T7370 T7371 nsubj LCA,is
R4444 T7372 T7373 det a,disease
R4445 T7373 T7371 attr disease,is
R4446 T7374 T7375 prep in,is
R4447 T7375 T7373 relcl is,disease
R4448 T7376 T7374 pobj which,in
R4449 T7377 T7375 expl there,is
R4450 T7378 T7379 amod little,function
R4451 T7379 T7375 attr function,is
R4452 T7380 T7378 cc or,little
R4453 T7381 T7378 conj no,little
R4454 T7382 T7379 compound photoreceptor,function
R4455 T7383 T7375 prep in,is
R4456 T7384 T7383 pobj infancy,in
R4457 T7385 T7373 punct ;,disease
R4458 T7386 T7387 advmod thereby,developmental
R4459 T7387 T7373 conj developmental,disease
R4460 T7388 T7387 punct ", ",developmental
R4461 T7389 T7387 advmod likely,developmental
R4462 T7390 T7387 prep in,developmental
R4463 T7391 T7390 pobj etiology,in
R4464 T7392 T7393 punct (,56
R4465 T7393 T7371 parataxis 56,is
R4466 T7394 T7393 punct [,56
R4467 T7395 T7393 nummod 17,56
R4468 T7396 T7393 punct ",",56
R4469 T7397 T7393 punct ],56
R4470 T7398 T7393 prep for,56
R4471 T7399 T7398 pobj review,for
R4472 T7400 T7393 punct ),56
R4473 T7401 T7371 punct .,is
R4474 T7403 T7404 det The,mouse
R4475 T7404 T7409 nsubj mouse,be
R4476 T7405 T7404 nmod Crx,mouse
R4477 T7406 T7405 punct -,Crx
R4478 T7407 T7405 punct /,Crx
R4479 T7408 T7405 punct -,Crx
R4480 T7410 T7409 aux may,be
R4481 T7411 T7412 det an,model
R4482 T7412 T7409 attr model,be
R4483 T7413 T7412 amod excellent,model
R4484 T7414 T7412 prep for,model
R4485 T7415 T7414 pcomp studying,for
R4486 T7416 T7417 det the,pathology
R4487 T7417 T7415 dobj pathology,studying
R4488 T7418 T7417 prep of,pathology
R4489 T7419 T7420 det this,disorder
R4490 T7420 T7418 pobj disorder,of
R4491 T7421 T7420 punct ", ",disorder
R4492 T7422 T7423 advmod particularly,subtype
R4493 T7423 T7420 appos subtype,disorder
R4494 T7424 T7423 det the,subtype
R4495 T7425 T7423 prep of,subtype
R4496 T7426 T7427 det the,disorder
R4497 T7427 T7425 pobj disorder,of
R4498 T7428 T7429 advmod where,involved
R4499 T7429 T7423 relcl involved,subtype
R4500 T7430 T7431 compound Crx,mutations
R4501 T7431 T7429 nsubjpass mutations,involved
R4502 T7432 T7429 auxpass are,involved
R4503 T7433 T7409 punct .,be
R4504 T7435 T7436 det The,majority
R4505 T7436 T7438 nsubjpass majority,derived
R4506 T7437 T7436 amod vast,majority
R4507 T7439 T7436 prep of,majority
R4508 T7440 T7441 amod histopathological,studies
R4509 T7441 T7439 pobj studies,of
R4510 T7442 T7441 prep of,studies
R4511 T7443 T7442 pobj LCA,of
R4512 T7444 T7441 prep in,studies
R4513 T7445 T7446 amod human,tissue
R4514 T7446 T7444 pobj tissue,in
R4515 T7447 T7438 aux have,derived
R4516 T7448 T7438 auxpass been,derived
R4517 T7449 T7438 prep from,derived
R4518 T7450 T7451 amod adult,patients
R4519 T7451 T7449 pobj patients,from
R4520 T7452 T7451 prep with,patients
R4521 T7453 T7452 pobj LCA,with
R4522 T7454 T7455 advmod where,are
R4523 T7455 T7451 relcl are,patients
R4524 T7456 T7457 amod secondary,changes
R4525 T7457 T7455 nsubj changes,are
R4526 T7458 T7455 acomp likely,are
R4527 T7459 T7460 aux to,be
R4528 T7460 T7458 xcomp be,likely
R4529 T7461 T7460 acomp present,be
R4530 T7462 T7438 punct .,derived
R4531 T7464 T7465 advmod Indeed,occur
R4532 T7466 T7465 prep in,occur
R4533 T7467 T7468 compound animal,models
R4534 T7468 T7466 pobj models,in
R4535 T7469 T7468 prep of,models
R4536 T7470 T7469 pobj LCA,of
R4537 T7471 T7465 punct ", ",occur
R4538 T7472 T7473 amod secondary,changes
R4539 T7473 T7465 nsubj changes,occur
R4540 T7474 T7473 amod reactive,changes
R4541 T7475 T7474 cc and,reactive
R4542 T7476 T7475 punct /,and
R4543 T7477 T7475 cc or,and
R4544 T7478 T7474 conj degenerative,reactive
R4545 T7479 T7480 advmod early,after
R4546 T7480 T7465 prep after,occur
R4547 T7481 T7482 det the,formation
R4548 T7482 T7480 pobj formation,after
R4549 T7483 T7482 amod abnormal,formation
R4550 T7484 T7482 prep of,formation
R4551 T7485 T7486 amod retinal,tissue
R4552 T7486 T7484 pobj tissue,of
R4553 T7487 T7488 punct [,57
R4554 T7488 T7465 parataxis 57,occur
R4555 T7489 T7488 punct ],57
R4556 T7490 T7465 punct .,occur
R4557 T7492 T7493 det The,study
R4558 T7493 T7495 nsubjpass study,reported
R4559 T7494 T7493 amod only,study
R4560 T7496 T7493 prep in,study
R4561 T7497 T7498 amod human,tissue
R4562 T7498 T7496 pobj tissue,in
R4563 T7499 T7498 acl derived,tissue
R4564 T7500 T7499 prep from,derived
R4565 T7501 T7502 det a,retina
R4566 T7502 T7500 pobj retina,from
R4567 T7503 T7502 amod human,retina
R4568 T7504 T7505 nummod 33,week
R4569 T7505 T7502 compound week,retina
R4570 T7506 T7505 punct -,week
R4571 T7507 T7502 prep with,retina
R4572 T7508 T7509 amod proposed,mutations
R4573 T7509 T7507 pobj mutations,with
R4574 T7510 T7509 compound RPE65,mutations
R4575 T7511 T7495 auxpass was,reported
R4576 T7512 T7513 aux to,have
R4577 T7513 T7495 xcomp have,reported
R4578 T7514 T7515 amod abnormal,retinae
R4579 T7515 T7513 dobj retinae,have
R4580 T7516 T7513 prep at,have
R4581 T7517 T7518 det this,stage
R4582 T7518 T7516 pobj stage,at
R4583 T7519 T7518 amod early,stage
R4584 T7520 T7521 punct [,24
R4585 T7521 T7495 parataxis 24,reported
R4586 T7522 T7521 punct ],24
R4587 T7523 T7495 punct .,reported
R4588 T7525 T7526 det These,authors
R4589 T7526 T7527 nsubj authors,report
R4590 T7528 T7529 compound cell,loss
R4591 T7529 T7527 dobj loss,report
R4592 T7530 T7529 punct ", ",loss
R4593 T7531 T7529 prep including,loss
R4594 T7532 T7531 pobj thinning,including
R4595 T7533 T7532 prep of,thinning
R4596 T7534 T7535 det the,layer
R4597 T7535 T7533 pobj layer,of
R4598 T7536 T7535 compound photoreceptor,layer
R4599 T7537 T7527 punct .,report
R4600 T7539 T7540 prep In,claim
R4601 T7541 T7539 pobj addition,In
R4602 T7542 T7540 punct ", ",claim
R4603 T7543 T7540 nsubj they,claim
R4604 T7544 T7540 prep in,claim
R4605 T7545 T7546 det the,text
R4606 T7546 T7544 pobj text,in
R4607 T7547 T7548 aux to,seen
R4608 T7548 T7540 xcomp seen,claim
R4609 T7549 T7548 aux have,seen
R4610 T7550 T7551 amod aberrant,organization
R4611 T7551 T7548 dobj organization,seen
R4612 T7552 T7551 amod synaptic,organization
R4613 T7553 T7552 cc and,synaptic
R4614 T7554 T7555 amod inner,retinal
R4615 T7555 T7552 conj retinal,synaptic
R4616 T7556 T7548 punct ", ",seen
R4617 T7557 T7558 mark although,presented
R4618 T7558 T7548 advcl presented,seen
R4619 T7559 T7560 poss their,examination
R4620 T7560 T7558 nsubjpass examination,presented
R4621 T7561 T7560 prep of,examination
R4622 T7562 T7563 compound photoreceptor,synapses
R4623 T7563 T7561 pobj synapses,of
R4624 T7564 T7558 advmod unfortunately,presented
R4625 T7565 T7558 auxpass are,presented
R4626 T7566 T7558 neg not,presented
R4627 T7567 T7558 prep in,presented
R4628 T7568 T7569 det the,section
R4629 T7569 T7567 pobj section,in
R4630 T7570 T7569 compound data,section
R4631 T7571 T7569 prep of,section
R4632 T7572 T7573 det the,paper
R4633 T7573 T7571 pobj paper,of
R4634 T7574 T7540 punct .,claim
R4635 T7576 T7577 prep Given,require
R4636 T7578 T7579 det the,scarcity
R4637 T7579 T7576 pobj scarcity,Given
R4638 T7580 T7579 prep of,scarcity
R4639 T7581 T7582 amod available,tissue
R4640 T7582 T7580 pobj tissue,of
R4641 T7583 T7582 amod human,tissue
R4642 T7584 T7577 punct ", ",require
R4643 T7585 T7586 det the,characterization
R4644 T7586 T7577 nsubj characterization,require
R4645 T7587 T7586 prep of,characterization
R4646 T7588 T7589 det the,pathology
R4647 T7589 T7587 pobj pathology,of
R4648 T7590 T7589 amod primary,pathology
R4649 T7591 T7589 prep of,pathology
R4650 T7592 T7591 pobj LCA,of
R4651 T7593 T7577 aux will,require
R4652 T7594 T7595 compound animal,models
R4653 T7595 T7577 dobj models,require
R4654 T7596 T7577 punct .,require
R4655 T7598 T7599 prep In,present
R4656 T7600 T7601 det the,study
R4657 T7601 T7598 pobj study,In
R4658 T7602 T7601 amod current,study
R4659 T7603 T7599 punct ", ",present
R4660 T7604 T7599 nsubj we,present
R4661 T7605 T7599 dobj data,present
R4662 T7606 T7607 dep that,argue
R4663 T7607 T7605 relcl argue,data
R4664 T7608 T7609 mark that,be
R4665 T7609 T7607 ccomp be,argue
R4666 T7610 T7609 punct ", ",be
R4667 T7611 T7609 prep in,be
R4668 T7612 T7611 pobj addition,in
R4669 T7613 T7612 prep to,addition
R4670 T7614 T7615 amod outer,segment
R4671 T7615 T7616 compound segment,morphogenesis
R4672 T7616 T7613 pobj morphogenesis,to
R4673 T7617 T7609 punct ", ",be
R4674 T7618 T7609 nsubj synaptogenesis,be
R4675 T7619 T7609 aux may,be
R4676 T7620 T7609 advmod also,be
R4677 T7621 T7622 advmod critically,impaired
R4678 T7622 T7609 acomp impaired,be
R4679 T7623 T7609 prep in,be
R4680 T7624 T7625 advmod at,a
R4681 T7625 T7627 nummod a,subset
R4682 T7626 T7625 advmod least,a
R4683 T7627 T7623 pobj subset,in
R4684 T7628 T7627 prep of,subset
R4685 T7629 T7628 pobj LCA,of
R4686 T7630 T7599 punct .,present