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PMC:548520 / 1245-6397 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
15676071-9540407-12933239 345-346 9540407 denotes 1
15676071-14562518-12933239 345-346 14562518 denotes 1
15676071-12015282-12933239 345-346 12015282 denotes 1
15676071-14562518-12933240 712-713 14562518 denotes 2
15676071-14527271-12933241 714-715 14527271 denotes 4
15676071-9390516-12933242 876-877 9390516 denotes 5
15676071-9390563-12933242 876-877 9390563 denotes 5
15676071-9390562-12933242 876-877 9390562 denotes 5
15676071-14625556-12933243 1029-1030 14625556 denotes 8
15676071-10887186-12933244 1201-1202 10887186 denotes 9
15676071-10744971-12933245 1303-1305 10744971 denotes 10
15676071-8576239-12933246 1329-1331 8576239 denotes 11
15676071-10336455-12933247 1347-1349 10336455 denotes 12
15676071-9390563-12933248 1474-1475 9390563 denotes 6
15676071-9427255-12933249 1476-1478 9427255 denotes 13
15676071-9792858-12933250 1479-1481 9792858 denotes 14
15676071-9792858-12933251 1506-1508 9792858 denotes 14
15676071-9792858-12933252 1520-1522 9792858 denotes 14
15676071-9537410-12933252 1520-1522 9537410 denotes 14
15676071-9931337-12933252 1520-1522 9931337 denotes 14
15676071-9390516-12933253 1658-1659 9390516 denotes 5
15676071-9390562-12933254 1660-1661 9390562 denotes 7
15676071-15231395-12933255 1727-1729 15231395 denotes 17
15676071-9792858-12933256 1916-1918 9792858 denotes 14
15676071-9537410-12933257 1919-1921 9537410 denotes 15
15676071-8944027-12933258 1943-1945 8944027 denotes 18
15676071-9326927-12933259 1955-1957 9326927 denotes 19
15676071-10615133-12933260 1968-1970 10615133 denotes 20
15676071-12567265-12933261 1980-1982 12567265 denotes 21
15676071-11283794-12933262 1999-2001 11283794 denotes 22
15676071-10631161-12933263 2112-2114 10631161 denotes 23
15676071-9792858-12933264 2251-2253 9792858 denotes 14
15676071-9537410-12933265 2254-2256 9537410 denotes 15
15676071-9931337-12933266 2382-2384 9931337 denotes 16
15676071-15231395-12933267 2590-2592 15231395 denotes 17
15676071-12124981-12933268 2796-2798 12124981 denotes 24
15676071-9448321-12933269 2938-2940 9448321 denotes 25
15676071-15180294-12933269 2938-2940 15180294 denotes 25
15676071-12692160-12933269 2938-2940 12692160 denotes 25
15676071-11528395-12933269 2938-2940 11528395 denotes 25
15676071-9020854-12933270 3500-3502 9020854 denotes 29
15676071-6715580-12933271 3544-3546 6715580 denotes 30
15676071-13694328-12933272 3737-3739 13694328 denotes 31
15676071-10329014-12933273 4347-4349 10329014 denotes 33

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T627 11-30 CL:0000210 denotes Photoreceptor cells
T628 25-30 CL_GO_EXT:cell denotes cells
T629 54-60 GO:0007601 denotes vision
T630 110-116 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T631 132-139 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T632 132-147 CL:0000101 denotes sensory neurons
T633 176-185 NCBITaxon:1 denotes organisms
T634 197-204 GO_EXT:detection_or_sensing_of_stimulus denotes sensing
T635 215-221 NCBITaxon:9606 denotes humans
T636 223-230 SO_EXT:0000704 denotes genetic
T637 247-250 UBERON:0000970 denotes eye
T638 313-327 CL:0000210 denotes photoreceptors
T639 352-366 CL:0000210 denotes Photoreceptors
T640 441-451 GO_PATO_EXT:physiological_process_or_quality denotes physiology
T641 455-472 GO:0007602 denotes phototransduction
T642 491-505 _FRAGMENT denotes development of
T643 517-531 GO:0042461 denotes photoreceptors
T644 506-516 NCBITaxon:7742 denotes vertebrate
T645 517-531 CL:0000210 denotes photoreceptors
T646 620-629 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T647 641-651 GO:0065007 denotes regulating
T648 652-665 CL:0000210 denotes photoreceptor
T649 652-677 GO:0042461 denotes photoreceptor development
T650 719-722 PR_EXT:000005904 denotes Crx
T651 724-728 CL:0000573 denotes cone
T652 724-741 PR_EXT:000005904 denotes cone-rod homeobox
T653 729-732 CL:0000604 denotes rod
T654 749-752 PR_EXT:OTX denotes otx
T655 769-773 SO_EXT:0000704 denotes gene
T656 774-783 GO:0010467 denotes expressed
T657 801-815 CL:0000210 denotes photoreceptors
T658 864-869 UBERON:0007023 denotes adult
T659 882-885 PR_EXT:000005904 denotes Crx
T660 886-890 SO_EXT:0000704 denotes gene
T661 886-901 GO:0010467 denotes gene expression
T662 931-935 PR_EXT:000012086 denotes Otx2
T663 989-998 GO:0010467 denotes expressed
T664 1008-1027 CL:0000210 denotes photoreceptor cells
T665 1022-1027 CL_GO_EXT:cell denotes cells
T666 1036-1054 CL:0000604 denotes rod photoreceptors
T667 1056-1059 PR_EXT:000005904 denotes Crx
T668 1092-1095 PR_EXT:000011432 denotes Nrl
T669 1099-1106 CHEBI_SO_EXT:leucine denotes leucine
T670 1114-1121 CHEBI_PR_EXT:protein denotes protein
T671 1153-1163 GO:0010467 denotes expression
T672 1171-1177 UBERON:0000966 denotes retina
T673 1181-1199 CL:0000604 denotes rod photoreceptors
T674 1210-1223 CL:0000210 denotes photoreceptor
T675 1233-1238 SO_EXT:0000704 denotes genes
T676 1253-1256 PR_EXT:000005904 denotes Crx
T677 1257-1264 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T678 1257-1273 SO_EXT:0000409 denotes binding elements
T679 1283-1293 GO:0065007 denotes regulatory
T680 1283-1301 SO_EXT:0005836 denotes regulatory regions
T681 1318-1327 PR_EXT:000001245 denotes rhodopsin
T682 1337-1345 PR_EXT:arrestin denotes arrestin
T683 1352-1361 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T684 1365-1368 PR_EXT:000005904 denotes Crx
T685 1403-1408 NCBITaxon:9606 denotes human
T686 1452-1456 CL:0000573 denotes cone
T687 1457-1460 CL:0000604 denotes rod
T688 1549-1552 PR_EXT:000005904 denotes Crx
T689 1601-1616 _FRAGMENT denotes differentiation
T690 1634-1636 _FRAGMENT denotes of
T691 1651-1656 GO:0030154 denotes cells
T692 1637-1656 CL:0000210 denotes photoreceptor cells
T693 1651-1656 CL_GO_EXT:cell denotes cells
T694 1687-1694 SO_EXT:0000704 denotes genetic
T695 1706-1720 CL:0000210 denotes photoreceptors
T696 1816-1822 GO:0007601 denotes vision
T697 1828-1833 GO:0007567 denotes birth
T698 1835-1844 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T699 1848-1855 UBERON:0000966 denotes retinal
T700 1865-1870 SO_EXT:0000704 denotes genes
T701 1880-1883 PR_EXT:000005904 denotes Crx
T702 1935-1941 PR_EXT:000008353 denotes GUCY2D
T703 1948-1953 PR_EXT:000014179 denotes RPE65
T704 1960-1966 PR_EXT:000003876 denotes AIPL-1
T705 1973-1978 PR_EXT:000005848 denotes CRB-1
T706 1989-1997 PR_EXT:000014182 denotes RPGRIP-1
T707 2050-2073 SO_EXT:0000018 denotes genetically linked loci
T708 2080-2085 SO_EXT:0000704 denotes genes
T709 2117-2120 PR_EXT:000005904 denotes Crx
T710 2121-2130 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T711 2182-2190 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T712 2211-2217 SO_EXT:sequence_coding_function denotes encode
T713 2246-2249 PR_EXT:000005904 denotes Crx
T714 2269-2278 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T715 2320-2326 SO_EXT:0001023 denotes allele
T716 2327-2334 SO_EXT:sequence_coding_function denotes encodes
T717 2337-2344 CHEBI_PR_EXT:protein denotes protein
T718 2360-2363 CHEBI_SO_EXT:DNA denotes DNA
T719 2364-2371 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T720 2566-2571 NCBITaxon:9606 denotes human
T721 2640-2646 UBERON:0010230 denotes globes
T722 2650-2656 UBERON:0007023 denotes adults
T723 2677-2683 UBERON:0000479 denotes tissue
T724 2765-2768 UBERON:0000970 denotes eye
T725 2775-2781 UBERON_EXT:baby_or_infant denotes infant
T726 2801-2807 NCBITaxon:33208 denotes Animal
T727 2976-2987 SO_EXT:0000704 denotes genetically
T728 3023-3028 NCBITaxon:10088 denotes mouse
T729 3105-3118 CL:0000210 denotes photoreceptor
T730 3105-3130 GO:0042461 denotes photoreceptor development
T731 3199-3218 CL:0000210 denotes photoreceptor cells
T732 3213-3218 CL_GO_EXT:cell denotes cells
T733 3262-3270 CL:0000540 denotes neuronal
T734 3271-3286 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T735 3288-3307 CL:0000210 denotes Photoreceptor cells
T736 3302-3307 CL_GO_EXT:cell denotes cells
T737 3339-3343 GO:0045177 denotes apex
T738 3351-3358 CL:0000540 denotes neurons
T739 3366-3376 GO:0016020 denotes membranous
T740 3377-3390 GO:0001750 denotes outer segment
T741 3407-3415 CHEBI_PR_EXT:protein denotes proteins
T742 3432-3457 GO:0007602 denotes phototransduction cascade
T743 3476-3485 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T744 3489-3498 PR_EXT:000001245 denotes rhodopsin
T745 3523-3530 CHEBI_PR_EXT:protein denotes protein
T746 3532-3542 PR_EXT:peripherin denotes peripherin
T747 3580-3594 GO:0001750 denotes outer segments
T748 3620-3634 CL:0000210 denotes photoreceptors
T749 3650-3658 GO:0045202 denotes synaptic
T750 3659-3666 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T751 3694-3706 _FRAGMENT denotes processes of
T752 3730-3735 GO:0042995 denotes cells
T753 3707-3717 _FRAGMENT denotes horizontal
T754 3730-3735 CL:0000745 denotes cells
T755 3722-3735 CL:0000103 denotes bipolar cells
T756 3745-3748 CL:0000604 denotes Rod
T757 3745-3758 GO:0044317 denotes Rod spherules
T758 3785-3792 GO:0045202 denotes synapse
T759 3798-3801 CL:0000604 denotes rod
T760 3810-3819 GO:0030425 denotes dendrites
T761 3824-3838 GO:0043679 denotes axonal endings
T762 3831-3838 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T763 3842-3858 CL:0000745 denotes horizontal cells
T764 3853-3858 CL_GO_EXT:cell denotes cells
T765 3865-3872 GO:0045202 denotes synapse
T766 3925-3936 GO:0098793 denotes presynaptic
T767 3937-3946 GO:0005737 denotes cytoplasm
T768 3948-3952 CL:0000573 denotes Cone
T769 3948-3961 GO:0044316 denotes Cone pedicles
T770 3980-3988 GO:0045202 denotes synapses
T771 3998-4007 GO:0030425 denotes dendrites
T772 4011-4013 _FRAGMENT denotes on
T773 4019-4032 CL:0000749 denotes bipolar cells
T774 4014-4018 CL:0000573 denotes cone
T775 4027-4032 CL_GO_EXT:cell denotes cells
T776 4037-4053 CL:0000745 denotes horizontal cells
T777 4048-4053 CL_GO_EXT:cell denotes cells
T778 4083-4092 GO:0030425 denotes dendrites
T779 4096-4099 _FRAGMENT denotes off
T780 4105-4118 CL:0000750 denotes bipolar cells
T781 4100-4104 CL:0000573 denotes cone
T782 4113-4118 CL_GO_EXT:cell denotes cells
T783 4132-4142 GO:0065007 denotes regulating
T784 4147-4159 _FRAGMENT denotes formation of
T785 4178-4186 GO:0007416 denotes synapses
T786 4164-4177 CL:0000210 denotes photoreceptor
T787 4178-4186 GO:0045202 denotes synapses
T788 4224-4237 CL:0000210 denotes photoreceptor
T789 4238-4246 GO:0045202 denotes synaptic
T790 4247-4254 CHEBI_PR_EXT:protein denotes protein
T791 4256-4260 PR_EXT:000017084 denotes HRG4
T792 4283-4286 PR_EXT:000005904 denotes Crx
T793 4294-4302 SO_EXT:biological_sequence denotes sequence
T794 4310-4325 GO_EXT:transcription denotes transcriptional
T795 4310-4345 SO_EXT:0001679 denotes transcriptional regulatory sequence
T796 4326-4336 GO:0065007 denotes regulatory
T797 4371-4377 NCBITaxon:33208 denotes animal
T798 4420-4427 UBERON:0000966 denotes retinal
T799 4488-4496 CL:0000540 denotes neuronal
T800 4497-4512 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T801 4522-4529 GO:0045202 denotes synapse
T802 4522-4539 GO:0007416 denotes synapse formation
T803 4694-4709 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T804 4723-4729 UBERON:0000966 denotes retina
T805 4733-4736 PR_EXT:000005904 denotes Crx
T806 4736-4737 SO_EXT:sequence_nullness_or_absence denotes -
T807 4738-4739 SO_EXT:sequence_nullness_or_absence denotes -
T808 4740-4744 NCBITaxon:10088 denotes mice
T809 4781-4788 UBERON:0000966 denotes retinas
T810 4824-4827 PR_EXT:000005904 denotes Crx
T811 4827-4828 SO_EXT:sequence_nullness_or_absence denotes -
T812 4829-4830 SO_EXT:sequence_nullness_or_absence denotes -
T813 4831-4845 CL:0000210 denotes photoreceptors
T814 4878-4891 GO:0001750 denotes outer segment
T815 4942-4947 CL_GO_EXT:cell denotes cells
T816 4965-4973 GO:0045202 denotes synaptic
T817 5021-5024 PR_EXT:000005904 denotes Crx
T818 5028-5041 CL:0000210 denotes photoreceptor
T819 5042-5056 GO:0007416 denotes synaptogenesis
T820 5127-5134 GO:0045202 denotes synapse
T821 5127-5144 GO:0007416 denotes synapse formation
R212 T643 T642 _lexicallyChainedTo photoreceptors,development of
R213 T690 T689 _lexicallyChainedTo of,differentiation
R214 T691 T690 _lexicallyChainedTo cells,of
R215 T752 T751 _lexicallyChainedTo cells,processes of
R216 T754 T753 _lexicallyChainedTo cells,horizontal
R217 T773 T772 _lexicallyChainedTo bipolar cells,on
R218 T780 T779 _lexicallyChainedTo bipolar cells,off
R219 T785 T784 _lexicallyChainedTo synapses,formation of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T479 11-30 CL:0000210 denotes Photoreceptor cells
T480 54-60 GO:0007601 denotes vision
T481 132-147 CL:0000101 denotes sensory neurons
T482 176-185 NCBITaxon:1 denotes organisms
T483 215-221 NCBITaxon:9606 denotes humans
T484 223-230 SO:0000704 denotes genetic
T485 247-250 UBERON:0000970 denotes eye
T486 313-327 CL:0000210 denotes photoreceptors
T487 352-366 CL:0000210 denotes Photoreceptors
T488 455-472 GO:0007602 denotes phototransduction
T489 491-505 _FRAGMENT denotes development of
T490 517-531 GO:0042461 denotes photoreceptors
T491 506-516 NCBITaxon:7742 denotes vertebrate
T492 517-531 CL:0000210 denotes photoreceptors
T493 641-651 GO:0065007 denotes regulating
T494 652-665 CL:0000210 denotes photoreceptor
T495 652-677 GO:0042461 denotes photoreceptor development
T496 719-722 PR:000005904 denotes Crx
T497 724-728 CL:0000573 denotes cone
T498 724-741 PR:000005904 denotes cone-rod homeobox
T499 729-732 CL:0000604 denotes rod
T500 769-773 SO:0000704 denotes gene
T501 774-783 GO:0010467 denotes expressed
T502 801-815 CL:0000210 denotes photoreceptors
T503 864-869 UBERON:0007023 denotes adult
T504 882-885 PR:000005904 denotes Crx
T505 886-890 SO:0000704 denotes gene
T506 886-901 GO:0010467 denotes gene expression
T507 931-935 PR:000012086 denotes Otx2
T508 989-998 GO:0010467 denotes expressed
T509 1008-1027 CL:0000210 denotes photoreceptor cells
T510 1036-1054 CL:0000604 denotes rod photoreceptors
T511 1056-1059 PR:000005904 denotes Crx
T512 1092-1095 PR:000011432 denotes Nrl
T513 1153-1163 GO:0010467 denotes expression
T514 1171-1177 UBERON:0000966 denotes retina
T515 1181-1199 CL:0000604 denotes rod photoreceptors
T516 1210-1223 CL:0000210 denotes photoreceptor
T517 1233-1238 SO:0000704 denotes genes
T518 1253-1256 PR:000005904 denotes Crx
T519 1257-1273 SO:0000409 denotes binding elements
T520 1283-1293 GO:0065007 denotes regulatory
T521 1283-1301 SO:0005836 denotes regulatory regions
T522 1318-1327 PR:000001245 denotes rhodopsin
T523 1365-1368 PR:000005904 denotes Crx
T524 1403-1408 NCBITaxon:9606 denotes human
T525 1452-1456 CL:0000573 denotes cone
T526 1457-1460 CL:0000604 denotes rod
T527 1549-1552 PR:000005904 denotes Crx
T528 1601-1616 _FRAGMENT denotes differentiation
T529 1634-1636 _FRAGMENT denotes of
T530 1651-1656 GO:0030154 denotes cells
T531 1637-1656 CL:0000210 denotes photoreceptor cells
T532 1687-1694 SO:0000704 denotes genetic
T533 1706-1720 CL:0000210 denotes photoreceptors
T534 1816-1822 GO:0007601 denotes vision
T535 1828-1833 GO:0007567 denotes birth
T536 1848-1855 UBERON:0000966 denotes retinal
T537 1865-1870 SO:0000704 denotes genes
T538 1880-1883 PR:000005904 denotes Crx
T539 1935-1941 PR:000008353 denotes GUCY2D
T540 1948-1953 PR:000014179 denotes RPE65
T541 1960-1966 PR:000003876 denotes AIPL-1
T542 1973-1978 PR:000005848 denotes CRB-1
T543 1989-1997 PR:000014182 denotes RPGRIP-1
T544 2050-2073 SO:0000018 denotes genetically linked loci
T545 2080-2085 SO:0000704 denotes genes
T546 2117-2120 PR:000005904 denotes Crx
T547 2246-2249 PR:000005904 denotes Crx
T548 2320-2326 SO:0001023 denotes allele
T549 2566-2571 NCBITaxon:9606 denotes human
T550 2640-2646 UBERON:0010230 denotes globes
T551 2650-2656 UBERON:0007023 denotes adults
T552 2677-2683 UBERON:0000479 denotes tissue
T553 2765-2768 UBERON:0000970 denotes eye
T554 2801-2807 NCBITaxon:33208 denotes Animal
T555 2976-2987 SO:0000704 denotes genetically
T556 3023-3028 NCBITaxon:10088 denotes mouse
T557 3105-3118 CL:0000210 denotes photoreceptor
T558 3105-3130 GO:0042461 denotes photoreceptor development
T559 3199-3218 CL:0000210 denotes photoreceptor cells
T560 3262-3270 CL:0000540 denotes neuronal
T561 3288-3307 CL:0000210 denotes Photoreceptor cells
T562 3339-3343 GO:0045177 denotes apex
T563 3351-3358 CL:0000540 denotes neurons
T564 3366-3376 GO:0016020 denotes membranous
T565 3377-3390 GO:0001750 denotes outer segment
T566 3432-3457 GO:0007602 denotes phototransduction cascade
T567 3489-3498 PR:000001245 denotes rhodopsin
T568 3580-3594 GO:0001750 denotes outer segments
T569 3620-3634 CL:0000210 denotes photoreceptors
T570 3650-3658 GO:0045202 denotes synaptic
T571 3694-3706 _FRAGMENT denotes processes of
T572 3730-3735 GO:0042995 denotes cells
T573 3707-3717 _FRAGMENT denotes horizontal
T574 3730-3735 CL:0000745 denotes cells
T575 3722-3735 CL:0000103 denotes bipolar cells
T576 3745-3748 CL:0000604 denotes Rod
T577 3745-3758 GO:0044317 denotes Rod spherules
T578 3785-3792 GO:0045202 denotes synapse
T587 3948-3961 GO:0044316 denotes Cone pedicles
T588 3980-3988 GO:0045202 denotes synapses
T589 3998-4007 GO:0030425 denotes dendrites
T590 4011-4013 _FRAGMENT denotes on
T591 4019-4032 CL:0000749 denotes bipolar cells
T592 4014-4018 CL:0000573 denotes cone
T593 4037-4053 CL:0000745 denotes horizontal cells
T594 4083-4092 GO:0030425 denotes dendrites
T595 4096-4099 _FRAGMENT denotes off
T596 4105-4118 CL:0000750 denotes bipolar cells
T597 4100-4104 CL:0000573 denotes cone
T598 4132-4142 GO:0065007 denotes regulating
T599 4147-4159 _FRAGMENT denotes formation of
T600 4178-4186 GO:0007416 denotes synapses
T601 4164-4177 CL:0000210 denotes photoreceptor
T602 4178-4186 GO:0045202 denotes synapses
T603 4224-4237 CL:0000210 denotes photoreceptor
T604 4238-4246 GO:0045202 denotes synaptic
T605 4256-4260 PR:000017084 denotes HRG4
T606 4283-4286 PR:000005904 denotes Crx
T607 4310-4345 SO:0001679 denotes transcriptional regulatory sequence
T608 4326-4336 GO:0065007 denotes regulatory
T609 4371-4377 NCBITaxon:33208 denotes animal
T610 4420-4427 UBERON:0000966 denotes retinal
T611 4488-4496 CL:0000540 denotes neuronal
T612 4522-4529 GO:0045202 denotes synapse
T613 4522-4539 GO:0007416 denotes synapse formation
T614 4723-4729 UBERON:0000966 denotes retina
T615 4733-4736 PR:000005904 denotes Crx
T616 4740-4744 NCBITaxon:10088 denotes mice
T617 4781-4788 UBERON:0000966 denotes retinas
T618 4824-4827 PR:000005904 denotes Crx
T619 4831-4845 CL:0000210 denotes photoreceptors
T620 4878-4891 GO:0001750 denotes outer segment
T621 4965-4973 GO:0045202 denotes synaptic
T622 5021-5024 PR:000005904 denotes Crx
T623 5028-5041 CL:0000210 denotes photoreceptor
T624 5042-5056 GO:0007416 denotes synaptogenesis
T625 5127-5134 GO:0045202 denotes synapse
T626 5127-5144 GO:0007416 denotes synapse formation
T579 3798-3801 CL:0000604 denotes rod
T580 3810-3819 GO:0030425 denotes dendrites
T581 3824-3838 GO:0043679 denotes axonal endings
T582 3842-3858 CL:0000745 denotes horizontal cells
T583 3865-3872 GO:0045202 denotes synapse
T584 3925-3936 GO:0098793 denotes presynaptic
T585 3937-3946 GO:0005737 denotes cytoplasm
T586 3948-3952 CL:0000573 denotes Cone
R208 T574 T573 _lexicallyChainedTo cells,horizontal
R209 T591 T590 _lexicallyChainedTo bipolar cells,on
R210 T596 T595 _lexicallyChainedTo bipolar cells,off
R211 T600 T599 _lexicallyChainedTo synapses,formation of
R204 T490 T489 _lexicallyChainedTo photoreceptors,development of
R205 T529 T528 _lexicallyChainedTo of,differentiation
R206 T530 T529 _lexicallyChainedTo cells,of
R207 T572 T571 _lexicallyChainedTo cells,processes of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T822 11-24 NN denotes Photoreceptor
T823 25-30 NNS denotes cells
T824 31-35 VBP denotes play
T825 36-37 DT denotes a
T826 46-50 NN denotes role
T827 38-45 JJ denotes primary
T828 51-53 IN denotes in
T829 54-60 NN denotes vision
T830 61-63 IN denotes by
T831 64-73 VBG denotes capturing
T832 74-79 NN denotes light
T833 80-86 NN denotes energy
T834 87-90 CC denotes and
T835 91-101 VBG denotes converting
T836 102-104 PRP denotes it
T837 105-109 IN denotes into
T838 110-116 JJ denotes neural
T839 117-124 NNS denotes stimuli
T840 124-125 . denotes .
T841 125-211 sentence denotes These sensory neurons are a shared element in all organisms capable of sensing light.
T842 126-131 DT denotes These
T843 140-147 NNS denotes neurons
T844 132-139 JJ denotes sensory
T845 148-151 VBP denotes are
T846 152-153 DT denotes a
T847 161-168 NN denotes element
T848 154-160 VBN denotes shared
T849 169-171 IN denotes in
T850 172-175 DT denotes all
T851 176-185 NNS denotes organisms
T852 186-193 JJ denotes capable
T853 194-196 IN denotes of
T854 197-204 VBG denotes sensing
T855 205-210 NN denotes light
T856 210-211 . denotes .
T857 211-351 sentence denotes In humans, genetic diseases of the eye are common and the primary site of disease is most frequently photoreceptors (for review see [1-3]).
T858 212-214 IN denotes In
T859 251-254 VBP denotes are
T860 215-221 NNS denotes humans
T861 221-223 , denotes ,
T862 223-230 JJ denotes genetic
T863 231-239 NNS denotes diseases
T864 240-242 IN denotes of
T865 243-246 DT denotes the
T866 247-250 NN denotes eye
T867 255-261 JJ denotes common
T868 262-265 CC denotes and
T869 266-269 DT denotes the
T870 278-282 NN denotes site
T871 270-277 JJ denotes primary
T872 294-296 VBZ denotes is
T873 283-285 IN denotes of
T874 286-293 NN denotes disease
T875 297-301 RBS denotes most
T876 302-312 RB denotes frequently
T877 313-327 NNS denotes photoreceptors
T878 328-329 -LRB- denotes (
T879 340-343 VBP denotes see
T880 329-332 IN denotes for
T881 333-339 NN denotes review
T882 344-345 -LRB- denotes [
T883 345-346 CD denotes 1
T884 346-347 SYM denotes -
T885 347-348 CD denotes 3
T886 348-349 -RRB- denotes ]
T887 349-350 -RRB- denotes )
T888 350-351 . denotes .
T889 351-473 sentence denotes Photoreceptors have been well studied, particularly with respect to the biochemistry and physiology of phototransduction.
T890 352-366 NNS denotes Photoreceptors
T891 382-389 VBN denotes studied
T892 367-371 VBP denotes have
T893 372-376 VBN denotes been
T894 377-381 RB denotes well
T895 389-391 , denotes ,
T896 391-403 RB denotes particularly
T897 404-408 IN denotes with
T898 409-416 NN denotes respect
T899 417-419 IN denotes to
T900 420-423 DT denotes the
T901 424-436 NN denotes biochemistry
T902 437-440 CC denotes and
T903 441-451 NN denotes physiology
T904 452-454 IN denotes of
T905 455-472 NN denotes phototransduction
T906 472-473 . denotes .
T907 473-590 sentence denotes Insight into the development of vertebrate photoreceptors, however, has lagged behind our understanding of function.
T908 474-481 NN denotes Insight
T909 546-552 VBN denotes lagged
T910 482-486 IN denotes into
T911 487-490 DT denotes the
T912 491-502 NN denotes development
T913 503-505 IN denotes of
T914 506-516 NN denotes vertebrate
T915 517-531 NNS denotes photoreceptors
T916 531-533 , denotes ,
T917 533-540 RB denotes however
T918 540-542 , denotes ,
T919 542-545 VBZ denotes has
T920 553-559 IN denotes behind
T921 560-563 PRP$ denotes our
T922 564-577 NN denotes understanding
T923 578-580 IN denotes of
T924 581-589 NN denotes function
T925 589-590 . denotes .
T926 590-718 sentence denotes Only recently have the first molecular mechanisms regulating photoreceptor development been identified (for review see, [2,4]).
T927 591-595 RB denotes Only
T928 596-604 RB denotes recently
T929 683-693 VBN denotes identified
T930 605-609 VB denotes have
T931 610-613 DT denotes the
T932 630-640 NNS denotes mechanisms
T933 614-619 JJ denotes first
T934 620-629 JJ denotes molecular
T935 641-651 VBG denotes regulating
T936 652-665 NN denotes photoreceptor
T937 666-677 NN denotes development
T938 678-682 VBN denotes been
T939 694-695 -LRB- denotes (
T940 706-709 VB denotes see
T941 695-698 IN denotes for
T942 699-705 NN denotes review
T943 709-711 , denotes ,
T944 711-712 -LRB- denotes [
T945 712-713 CD denotes 2
T946 714-715 CD denotes 4
T947 713-714 , denotes ,
T948 715-716 -RRB- denotes ]
T949 716-717 -RRB- denotes )
T950 717-718 . denotes .
T951 718-881 sentence denotes Crx (cone-rod homeobox) is an otx-family homeobox gene expressed predominantly in photoreceptors, from early in their development through to the adult ages [5-7].
T952 719-722 NN denotes Crx
T953 743-745 VBZ denotes is
T954 723-724 -LRB- denotes (
T955 724-728 NN denotes cone
T956 729-732 NN denotes rod
T957 728-729 HYPH denotes -
T958 733-741 NN denotes homeobox
T959 741-742 -RRB- denotes )
T960 746-748 DT denotes an
T961 769-773 NN denotes gene
T962 749-752 NN denotes otx
T963 753-759 NN denotes family
T964 752-753 HYPH denotes -
T965 760-768 NN denotes homeobox
T966 774-783 VBN denotes expressed
T967 784-797 RB denotes predominantly
T968 798-800 IN denotes in
T969 801-815 NNS denotes photoreceptors
T970 815-817 , denotes ,
T971 817-821 IN denotes from
T972 822-827 RB denotes early
T973 828-830 IN denotes in
T974 831-836 PRP$ denotes their
T975 837-848 NN denotes development
T976 849-856 IN denotes through
T977 857-859 IN denotes to
T978 860-863 DT denotes the
T979 870-874 NNS denotes ages
T980 864-869 JJ denotes adult
T981 875-876 -LRB- denotes [
T982 876-877 CD denotes 5
T983 877-878 SYM denotes -
T984 878-879 CD denotes 7
T985 879-880 -RRB- denotes ]
T986 880-881 . denotes .
T987 881-1032 sentence denotes Crx gene expression is critically dependent upon Otx2, another member of the same homeobox family which is expressed in early photoreceptor cells [8].
T988 882-885 NN denotes Crx
T989 891-901 NN denotes expression
T990 886-890 NN denotes gene
T991 902-904 VBZ denotes is
T992 905-915 RB denotes critically
T993 916-925 JJ denotes dependent
T994 926-930 IN denotes upon
T995 931-935 NN denotes Otx2
T996 935-937 , denotes ,
T997 937-944 DT denotes another
T998 945-951 NN denotes member
T999 952-954 IN denotes of
T1000 955-958 DT denotes the
T1001 973-979 NN denotes family
T1002 959-963 JJ denotes same
T1003 964-972 NN denotes homeobox
T1004 980-985 WDT denotes which
T1005 989-998 VBN denotes expressed
T1006 986-988 VBZ denotes is
T1007 999-1001 IN denotes in
T1008 1002-1007 JJ denotes early
T1009 1022-1027 NNS denotes cells
T1010 1008-1021 NN denotes photoreceptor
T1011 1028-1029 -LRB- denotes [
T1012 1029-1030 CD denotes 8
T1013 1030-1031 -RRB- denotes ]
T1014 1031-1032 . denotes .
T1015 1032-1204 sentence denotes In rod photoreceptors, Crx appears to work in concert with Nrl, a leucine zipper protein that is also restricted in its expression in the retina to rod photoreceptors [9].
T1016 1033-1035 IN denotes In
T1017 1060-1067 VBZ denotes appears
T1018 1036-1039 NN denotes rod
T1019 1040-1054 NNS denotes photoreceptors
T1020 1054-1056 , denotes ,
T1021 1056-1059 NN denotes Crx
T1022 1068-1070 TO denotes to
T1023 1071-1075 VB denotes work
T1024 1076-1078 IN denotes in
T1025 1079-1086 NN denotes concert
T1026 1087-1091 IN denotes with
T1027 1092-1095 NN denotes Nrl
T1028 1095-1097 , denotes ,
T1029 1097-1098 DT denotes a
T1030 1114-1121 NN denotes protein
T1031 1099-1106 NN denotes leucine
T1032 1107-1113 NN denotes zipper
T1033 1122-1126 WDT denotes that
T1034 1135-1145 VBN denotes restricted
T1035 1127-1129 VBZ denotes is
T1036 1130-1134 RB denotes also
T1037 1146-1148 IN denotes in
T1038 1149-1152 PRP$ denotes its
T1039 1153-1163 NN denotes expression
T1040 1164-1166 IN denotes in
T1041 1167-1170 DT denotes the
T1042 1171-1177 NN denotes retina
T1043 1178-1180 IN denotes to
T1044 1181-1184 NN denotes rod
T1045 1185-1199 NNS denotes photoreceptors
T1046 1200-1201 -LRB- denotes [
T1047 1201-1202 CD denotes 9
T1048 1202-1203 -RRB- denotes ]
T1049 1203-1204 . denotes .
T1050 1204-1351 sentence denotes Many photoreceptor-specific genes have putative Crx-binding elements in their regulatory regions [10], including rhodopsin [11] and arrestin [12].
T1051 1205-1209 JJ denotes Many
T1052 1233-1238 NNS denotes genes
T1053 1210-1223 NN denotes photoreceptor
T1054 1224-1232 JJ denotes specific
T1055 1223-1224 HYPH denotes -
T1056 1239-1243 VBP denotes have
T1057 1244-1252 JJ denotes putative
T1058 1265-1273 NNS denotes elements
T1059 1253-1256 NN denotes Crx
T1060 1257-1264 VBG denotes binding
T1061 1256-1257 HYPH denotes -
T1062 1274-1276 IN denotes in
T1063 1277-1282 PRP$ denotes their
T1064 1294-1301 NNS denotes regions
T1065 1283-1293 JJ denotes regulatory
T1066 1302-1303 -LRB- denotes [
T1067 1303-1305 CD denotes 10
T1068 1305-1306 -RRB- denotes ]
T1069 1306-1308 , denotes ,
T1070 1308-1317 VBG denotes including
T1071 1318-1327 NN denotes rhodopsin
T1072 1328-1329 -LRB- denotes [
T1073 1329-1331 CD denotes 11
T1074 1331-1332 -RRB- denotes ]
T1075 1333-1336 CC denotes and
T1076 1337-1345 NN denotes arrestin
T1077 1346-1347 -LRB- denotes [
T1078 1347-1349 CD denotes 12
T1079 1349-1350 -RRB- denotes ]
T1080 1350-1351 . denotes .
T1081 1351-1527 sentence denotes Mutations in Crx have been associated with several human diseases that lead to blindness, including cone-rod dystrophy 2 [6,13,14], retinitis pigmentosa [14], and LCA [14-16].
T1082 1352-1361 NNS denotes Mutations
T1083 1379-1389 VBN denotes associated
T1084 1362-1364 IN denotes in
T1085 1365-1368 NN denotes Crx
T1086 1369-1373 VBP denotes have
T1087 1374-1378 VBN denotes been
T1088 1390-1394 IN denotes with
T1089 1395-1402 JJ denotes several
T1090 1409-1417 NNS denotes diseases
T1091 1403-1408 JJ denotes human
T1092 1418-1422 WDT denotes that
T1093 1423-1427 VBP denotes lead
T1094 1428-1430 IN denotes to
T1095 1431-1440 NN denotes blindness
T1096 1440-1442 , denotes ,
T1097 1442-1451 VBG denotes including
T1098 1452-1456 NN denotes cone
T1099 1457-1460 NN denotes rod
T1100 1456-1457 HYPH denotes -
T1101 1461-1470 NN denotes dystrophy
T1102 1471-1472 CD denotes 2
T1103 1473-1474 -LRB- denotes [
T1104 1479-1481 CD denotes 14
T1105 1474-1475 CD denotes 6
T1106 1475-1476 , denotes ,
T1107 1476-1478 CD denotes 13
T1108 1478-1479 , denotes ,
T1109 1481-1482 -RRB- denotes ]
T1110 1482-1484 , denotes ,
T1111 1484-1493 NN denotes retinitis
T1112 1494-1504 NN denotes pigmentosa
T1113 1505-1506 -LRB- denotes [
T1114 1506-1508 CD denotes 14
T1115 1508-1509 -RRB- denotes ]
T1116 1509-1511 , denotes ,
T1117 1511-1514 CC denotes and
T1118 1515-1518 NN denotes LCA
T1119 1519-1520 -LRB- denotes [
T1120 1520-1522 CD denotes 14
T1121 1522-1523 SYM denotes -
T1122 1523-1525 CD denotes 16
T1123 1525-1526 -RRB- denotes ]
T1124 1526-1527 . denotes .
T1125 1527-1663 sentence denotes Based on these data, Crx was hypothesized to play a critical role in the differentiation and maintainance of photoreceptor cells [5,7].
T1126 1528-1533 VBN denotes Based
T1127 1557-1569 VBN denotes hypothesized
T1128 1534-1536 IN denotes on
T1129 1537-1542 DT denotes these
T1130 1543-1547 NNS denotes data
T1131 1547-1549 , denotes ,
T1132 1549-1552 NN denotes Crx
T1133 1553-1556 VBD denotes was
T1134 1570-1572 TO denotes to
T1135 1573-1577 VB denotes play
T1136 1578-1579 DT denotes a
T1137 1589-1593 NN denotes role
T1138 1580-1588 JJ denotes critical
T1139 1594-1596 IN denotes in
T1140 1597-1600 DT denotes the
T1141 1601-1616 NN denotes differentiation
T1142 1617-1620 CC denotes and
T1143 1621-1633 NN denotes maintainance
T1144 1634-1636 IN denotes of
T1145 1637-1650 NN denotes photoreceptor
T1146 1651-1656 NNS denotes cells
T1147 1657-1658 -LRB- denotes [
T1148 1660-1661 CD denotes 7
T1149 1658-1659 CD denotes 5
T1150 1659-1660 , denotes ,
T1151 1661-1662 -RRB- denotes ]
T1152 1662-1663 . denotes .
T1153 1663-1751 sentence denotes LCA is the most severe genetic disease of photoreceptors (see [17], for recent review).
T1154 1664-1667 NN denotes LCA
T1155 1668-1670 VBZ denotes is
T1156 1671-1674 DT denotes the
T1157 1695-1702 NN denotes disease
T1158 1675-1679 RBS denotes most
T1159 1680-1686 JJ denotes severe
T1160 1687-1694 JJ denotes genetic
T1161 1703-1705 IN denotes of
T1162 1706-1720 NNS denotes photoreceptors
T1163 1721-1722 -LRB- denotes (
T1164 1722-1725 VB denotes see
T1165 1726-1727 -LRB- denotes [
T1166 1727-1729 CD denotes 17
T1167 1729-1730 -RRB- denotes ]
T1168 1730-1732 , denotes ,
T1169 1732-1735 IN denotes for
T1170 1736-1742 JJ denotes recent
T1171 1743-1749 NN denotes review
T1172 1749-1750 -RRB- denotes )
T1173 1750-1751 . denotes .
T1174 1751-1834 sentence denotes Affected infants exhibit a complete or near complete absence of vision from birth.
T1175 1752-1760 VBN denotes Affected
T1176 1761-1768 NNS denotes infants
T1177 1769-1776 VBP denotes exhibit
T1178 1777-1778 DT denotes a
T1179 1805-1812 NN denotes absence
T1180 1779-1787 JJ denotes complete
T1181 1788-1790 CC denotes or
T1182 1791-1795 RB denotes near
T1183 1796-1804 JJ denotes complete
T1184 1813-1815 IN denotes of
T1185 1816-1822 NN denotes vision
T1186 1823-1827 IN denotes from
T1187 1828-1833 NN denotes birth
T1188 1833-1834 . denotes .
T1189 1834-2003 sentence denotes Mutations in retinal specific genes, such as Crx, have been associated with LCA [14,15], as well as GUCY2D [18], RPE65 [19], AIPL-1 [20], CRB-1 [21], and RPGRIP-1 [22].
T1190 1835-1844 NNS denotes Mutations
T1191 1895-1905 VBN denotes associated
T1192 1845-1847 IN denotes in
T1193 1848-1855 NN denotes retinal
T1194 1856-1864 JJ denotes specific
T1195 1865-1870 NNS denotes genes
T1196 1870-1872 , denotes ,
T1197 1872-1876 JJ denotes such
T1198 1877-1879 IN denotes as
T1199 1880-1883 NN denotes Crx
T1200 1883-1885 , denotes ,
T1201 1885-1889 VBP denotes have
T1202 1890-1894 VBN denotes been
T1203 1906-1910 IN denotes with
T1204 1911-1914 NN denotes LCA
T1205 1915-1916 -LRB- denotes [
T1206 1919-1921 CD denotes 15
T1207 1916-1918 CD denotes 14
T1208 1918-1919 , denotes ,
T1209 1921-1922 -RRB- denotes ]
T1210 1922-1924 , denotes ,
T1211 1924-1926 RB denotes as
T1212 1932-1934 IN denotes as
T1213 1927-1931 RB denotes well
T1214 1935-1941 NN denotes GUCY2D
T1215 1942-1943 -LRB- denotes [
T1216 1943-1945 CD denotes 18
T1217 1945-1946 -RRB- denotes ]
T1218 1946-1948 , denotes ,
T1219 1948-1953 NN denotes RPE65
T1220 1954-1955 -LRB- denotes [
T1221 1955-1957 CD denotes 19
T1222 1957-1958 -RRB- denotes ]
T1223 1958-1960 , denotes ,
T1224 1960-1964 NN denotes AIPL
T1225 1964-1965 HYPH denotes -
T1226 1965-1966 CD denotes 1
T1227 1967-1968 -LRB- denotes [
T1228 1968-1970 CD denotes 20
T1229 1970-1971 -RRB- denotes ]
T1230 1971-1973 , denotes ,
T1231 1973-1976 NN denotes CRB
T1232 1976-1977 HYPH denotes -
T1233 1977-1978 CD denotes 1
T1234 1979-1980 -LRB- denotes [
T1235 1980-1982 CD denotes 21
T1236 1982-1983 -RRB- denotes ]
T1237 1983-1985 , denotes ,
T1238 1985-1988 CC denotes and
T1239 1989-1995 NN denotes RPGRIP
T1240 1995-1996 HYPH denotes -
T1241 1996-1997 CD denotes 1
T1242 1998-1999 -LRB- denotes [
T1243 1999-2001 CD denotes 22
T1244 2001-2002 -RRB- denotes ]
T1245 2002-2003 . denotes .
T1246 2003-2116 sentence denotes There also may be as many as three additional genetically linked loci where genes have not been identified [23].
T1247 2004-2009 EX denotes There
T1248 2019-2021 VB denotes be
T1249 2010-2014 RB denotes also
T1250 2015-2018 MD denotes may
T1251 2022-2024 RB denotes as
T1252 2033-2038 CD denotes three
T1253 2025-2029 JJ denotes many
T1254 2030-2032 IN denotes as
T1255 2069-2073 NNS denotes loci
T1256 2039-2049 JJ denotes additional
T1257 2050-2061 RB denotes genetically
T1258 2062-2068 VBN denotes linked
T1259 2074-2079 WRB denotes where
T1260 2100-2110 VBN denotes identified
T1261 2080-2085 NNS denotes genes
T1262 2086-2090 VBP denotes have
T1263 2091-2094 RB denotes not
T1264 2095-2099 VBN denotes been
T1265 2111-2112 -LRB- denotes [
T1266 2112-2114 CD denotes 23
T1267 2114-2115 -RRB- denotes ]
T1268 2115-2116 . denotes .
T1269 2116-2258 sentence denotes Crx mutations in LCA are varied, and include a putative dominant mutation that is proposed to encode a dominant-negative form of Crx [14,15].
T1270 2117-2120 NN denotes Crx
T1271 2121-2130 NNS denotes mutations
T1272 2138-2141 VBP denotes are
T1273 2131-2133 IN denotes in
T1274 2134-2137 NN denotes LCA
T1275 2142-2148 JJ denotes varied
T1276 2148-2150 , denotes ,
T1277 2150-2153 CC denotes and
T1278 2154-2161 VBP denotes include
T1279 2162-2163 DT denotes a
T1280 2182-2190 NN denotes mutation
T1281 2164-2172 JJ denotes putative
T1282 2173-2181 JJ denotes dominant
T1283 2191-2195 WDT denotes that
T1284 2199-2207 VBN denotes proposed
T1285 2196-2198 VBZ denotes is
T1286 2208-2210 TO denotes to
T1287 2211-2217 VB denotes encode
T1288 2218-2219 DT denotes a
T1289 2238-2242 NN denotes form
T1290 2220-2228 JJ denotes dominant
T1291 2229-2237 JJ denotes negative
T1292 2228-2229 HYPH denotes -
T1293 2243-2245 IN denotes of
T1294 2246-2249 NN denotes Crx
T1295 2250-2251 -LRB- denotes [
T1296 2254-2256 CD denotes 15
T1297 2251-2253 CD denotes 14
T1298 2253-2254 , denotes ,
T1299 2256-2257 -RRB- denotes ]
T1300 2257-2258 . denotes .
T1301 2258-2386 sentence denotes Recessive mutations also have been reported and at least one allele encodes a protein with decreased DNA-binding activity [16].
T1302 2259-2268 JJ denotes Recessive
T1303 2269-2278 NNS denotes mutations
T1304 2294-2302 VBN denotes reported
T1305 2279-2283 RB denotes also
T1306 2284-2288 VBP denotes have
T1307 2289-2293 VBN denotes been
T1308 2303-2306 CC denotes and
T1309 2307-2309 RB denotes at
T1310 2316-2319 CD denotes one
T1311 2310-2315 RBS denotes least
T1312 2320-2326 NN denotes allele
T1313 2327-2334 VBZ denotes encodes
T1314 2335-2336 DT denotes a
T1315 2337-2344 NN denotes protein
T1316 2345-2349 IN denotes with
T1317 2350-2359 VBN denotes decreased
T1318 2372-2380 NN denotes activity
T1319 2360-2363 NN denotes DNA
T1320 2363-2364 HYPH denotes -
T1321 2364-2371 VBG denotes binding
T1322 2381-2382 -LRB- denotes [
T1323 2382-2384 CD denotes 16
T1324 2384-2385 -RRB- denotes ]
T1325 2385-2386 . denotes .
T1326 2386-2538 sentence denotes Histopathological and ultrastructural studies of LCA should enable a better understanding of the disease process, and the design of suitable therapies.
T1327 2387-2404 JJ denotes Histopathological
T1328 2425-2432 NNS denotes studies
T1329 2405-2408 CC denotes and
T1330 2409-2424 JJ denotes ultrastructural
T1331 2447-2453 VB denotes enable
T1332 2433-2435 IN denotes of
T1333 2436-2439 NN denotes LCA
T1334 2440-2446 MD denotes should
T1335 2454-2455 DT denotes a
T1336 2463-2476 NN denotes understanding
T1337 2456-2462 JJR denotes better
T1338 2477-2479 IN denotes of
T1339 2480-2483 DT denotes the
T1340 2492-2499 NN denotes process
T1341 2484-2491 NN denotes disease
T1342 2499-2501 , denotes ,
T1343 2501-2504 CC denotes and
T1344 2505-2508 DT denotes the
T1345 2509-2515 NN denotes design
T1346 2516-2518 IN denotes of
T1347 2519-2527 JJ denotes suitable
T1348 2528-2537 NNS denotes therapies
T1349 2537-2538 . denotes .
T1350 2538-2716 sentence denotes Few such studies exist for human LCA (reviewed in [17]) and the majority of such studies examine the globes of adults with LCA, after the tissue has undergone secondary changes.
T1351 2539-2542 JJ denotes Few
T1352 2548-2555 NNS denotes studies
T1353 2543-2547 JJ denotes such
T1354 2556-2561 VBP denotes exist
T1355 2562-2565 IN denotes for
T1356 2566-2571 JJ denotes human
T1357 2572-2575 NN denotes LCA
T1358 2576-2577 -LRB- denotes (
T1359 2577-2585 VBN denotes reviewed
T1360 2586-2588 IN denotes in
T1361 2589-2590 -LRB- denotes [
T1362 2590-2592 CD denotes 17
T1363 2592-2593 -RRB- denotes ]
T1364 2593-2594 -RRB- denotes )
T1365 2595-2598 CC denotes and
T1366 2599-2602 DT denotes the
T1367 2603-2611 NN denotes majority
T1368 2628-2635 VBP denotes examine
T1369 2612-2614 IN denotes of
T1370 2615-2619 JJ denotes such
T1371 2620-2627 NNS denotes studies
T1372 2636-2639 DT denotes the
T1373 2640-2646 NNS denotes globes
T1374 2647-2649 IN denotes of
T1375 2650-2656 NNS denotes adults
T1376 2657-2661 IN denotes with
T1377 2662-2665 NN denotes LCA
T1378 2665-2667 , denotes ,
T1379 2667-2672 IN denotes after
T1380 2688-2697 VBN denotes undergone
T1381 2673-2676 DT denotes the
T1382 2677-2683 NN denotes tissue
T1383 2684-2687 VBZ denotes has
T1384 2698-2707 JJ denotes secondary
T1385 2708-2715 NNS denotes changes
T1386 2715-2716 . denotes .
T1387 2716-2800 sentence denotes Only a single study exists where the developing eye of an infant was examined [24].
T1388 2717-2721 RB denotes Only
T1389 2731-2736 NN denotes study
T1390 2722-2723 DT denotes a
T1391 2724-2730 JJ denotes single
T1392 2737-2743 VBZ denotes exists
T1393 2744-2749 WRB denotes where
T1394 2786-2794 VBN denotes examined
T1395 2750-2753 DT denotes the
T1396 2765-2768 NN denotes eye
T1397 2754-2764 VBG denotes developing
T1398 2769-2771 IN denotes of
T1399 2772-2774 DT denotes an
T1400 2775-2781 NN denotes infant
T1401 2782-2785 VBD denotes was
T1402 2795-2796 -LRB- denotes [
T1403 2796-2798 CD denotes 24
T1404 2798-2799 -RRB- denotes ]
T1405 2799-2800 . denotes .
T1406 2800-2945 sentence denotes Animal models for LCA have recently been reported and have already served to broaden our understanding of the pathology of this disease [25-28].
T1407 2801-2807 NN denotes Animal
T1408 2808-2814 NNS denotes models
T1409 2842-2850 VBN denotes reported
T1410 2815-2818 IN denotes for
T1411 2819-2822 NN denotes LCA
T1412 2823-2827 VBP denotes have
T1413 2828-2836 RB denotes recently
T1414 2837-2841 VBN denotes been
T1415 2851-2854 CC denotes and
T1416 2855-2859 VBP denotes have
T1417 2868-2874 VBN denotes served
T1418 2860-2867 RB denotes already
T1419 2875-2877 TO denotes to
T1420 2878-2885 VB denotes broaden
T1421 2886-2889 PRP$ denotes our
T1422 2890-2903 NN denotes understanding
T1423 2904-2906 IN denotes of
T1424 2907-2910 DT denotes the
T1425 2911-2920 NN denotes pathology
T1426 2921-2923 IN denotes of
T1427 2924-2928 DT denotes this
T1428 2929-2936 NN denotes disease
T1429 2937-2938 -LRB- denotes [
T1430 2938-2940 CD denotes 25
T1431 2940-2941 SYM denotes -
T1432 2941-2943 CD denotes 28
T1433 2943-2944 -RRB- denotes ]
T1434 2944-2945 . denotes .
T1435 2945-3143 sentence denotes Since LCA is a clinically and genetically heterogeneous disorder, additional mouse models are in order to allow a full understanding of the many ways in which photoreceptor development can go awry.
T1436 2946-2951 IN denotes Since
T1437 2956-2958 VBZ denotes is
T1438 2952-2955 NN denotes LCA
T1439 3036-3039 VBP denotes are
T1440 2959-2960 DT denotes a
T1441 3002-3010 NN denotes disorder
T1442 2961-2971 RB denotes clinically
T1443 2988-3001 JJ denotes heterogeneous
T1444 2972-2975 CC denotes and
T1445 2976-2987 RB denotes genetically
T1446 3010-3012 , denotes ,
T1447 3012-3022 JJ denotes additional
T1448 3029-3035 NNS denotes models
T1449 3023-3028 NN denotes mouse
T1450 3040-3042 IN denotes in
T1451 3043-3048 NN denotes order
T1452 3049-3051 TO denotes to
T1453 3052-3057 VB denotes allow
T1454 3058-3059 DT denotes a
T1455 3065-3078 NN denotes understanding
T1456 3060-3064 JJ denotes full
T1457 3079-3081 IN denotes of
T1458 3082-3085 DT denotes the
T1459 3091-3095 NNS denotes ways
T1460 3086-3090 JJ denotes many
T1461 3096-3098 IN denotes in
T1462 3135-3137 VB denotes go
T1463 3099-3104 WDT denotes which
T1464 3105-3118 NN denotes photoreceptor
T1465 3119-3130 NN denotes development
T1466 3131-3134 MD denotes can
T1467 3138-3142 JJ denotes awry
T1468 3142-3143 . denotes .
T1469 3143-3287 sentence denotes In addition to their importance as a locus of disease, photoreceptor cells serve as an excellent model for studies in neuronal differentiation.
T1470 3144-3146 IN denotes In
T1471 3219-3224 VBP denotes serve
T1472 3147-3155 NN denotes addition
T1473 3156-3158 IN denotes to
T1474 3159-3164 PRP$ denotes their
T1475 3165-3175 NN denotes importance
T1476 3176-3178 IN denotes as
T1477 3179-3180 DT denotes a
T1478 3181-3186 NN denotes locus
T1479 3187-3189 IN denotes of
T1480 3190-3197 NN denotes disease
T1481 3197-3199 , denotes ,
T1482 3199-3212 NN denotes photoreceptor
T1483 3213-3218 NNS denotes cells
T1484 3225-3227 IN denotes as
T1485 3228-3230 DT denotes an
T1486 3241-3246 NN denotes model
T1487 3231-3240 JJ denotes excellent
T1488 3247-3250 IN denotes for
T1489 3251-3258 NNS denotes studies
T1490 3259-3261 IN denotes in
T1491 3262-3270 JJ denotes neuronal
T1492 3271-3286 NN denotes differentiation
T1493 3286-3287 . denotes .
T1494 3287-3329 sentence denotes Photoreceptor cells are highly polarized.
T1495 3288-3301 NN denotes Photoreceptor
T1496 3302-3307 NNS denotes cells
T1497 3308-3311 VBP denotes are
T1498 3312-3318 RB denotes highly
T1499 3319-3328 JJ denotes polarized
T1500 3328-3329 . denotes .
T1501 3329-3458 sentence denotes At their apex, these neurons have a membranous outer segment, which contains proteins involved in the phototransduction cascade.
T1502 3330-3332 IN denotes At
T1503 3359-3363 VBP denotes have
T1504 3333-3338 PRP$ denotes their
T1505 3339-3343 NN denotes apex
T1506 3343-3345 , denotes ,
T1507 3345-3350 DT denotes these
T1508 3351-3358 NNS denotes neurons
T1509 3364-3365 DT denotes a
T1510 3383-3390 NN denotes segment
T1511 3366-3376 JJ denotes membranous
T1512 3377-3382 JJ denotes outer
T1513 3390-3392 , denotes ,
T1514 3392-3397 WDT denotes which
T1515 3398-3406 VBZ denotes contains
T1516 3407-3415 NN denotes proteins
T1517 3416-3424 VBN denotes involved
T1518 3425-3427 IN denotes in
T1519 3428-3431 DT denotes the
T1520 3450-3457 NN denotes cascade
T1521 3432-3449 NN denotes phototransduction
T1522 3457-3458 . denotes .
T1523 3458-3595 sentence denotes Loss of function mutations in rhodopsin [29], or the structural protein, peripherin [30], result in an inability to form outer segments.
T1524 3459-3463 NN denotes Loss
T1525 3476-3485 NNS denotes mutations
T1526 3464-3466 IN denotes of
T1527 3467-3475 NN denotes function
T1528 3549-3555 VBP denotes result
T1529 3486-3488 IN denotes in
T1530 3489-3498 NN denotes rhodopsin
T1531 3499-3500 -LRB- denotes [
T1532 3500-3502 CD denotes 29
T1533 3502-3503 -RRB- denotes ]
T1534 3503-3505 , denotes ,
T1535 3505-3507 CC denotes or
T1536 3508-3511 DT denotes the
T1537 3523-3530 NN denotes protein
T1538 3512-3522 JJ denotes structural
T1539 3530-3532 , denotes ,
T1540 3532-3542 NN denotes peripherin
T1541 3543-3544 -LRB- denotes [
T1542 3544-3546 CD denotes 30
T1543 3546-3547 -RRB- denotes ]
T1544 3547-3549 , denotes ,
T1545 3556-3558 IN denotes in
T1546 3559-3561 DT denotes an
T1547 3562-3571 NN denotes inability
T1548 3572-3574 TO denotes to
T1549 3575-3579 VB denotes form
T1550 3580-3585 JJ denotes outer
T1551 3586-3594 NNS denotes segments
T1552 3594-3595 . denotes .
T1553 3595-3744 sentence denotes At the other extremity, photoreceptors terminate with synaptic endings that make contact with the processes of horizontal and bipolar cells [31,32].
T1554 3596-3598 IN denotes At
T1555 3635-3644 VBP denotes terminate
T1556 3599-3602 DT denotes the
T1557 3609-3618 NN denotes extremity
T1558 3603-3608 JJ denotes other
T1559 3618-3620 , denotes ,
T1560 3620-3634 NNS denotes photoreceptors
T1561 3645-3649 IN denotes with
T1562 3650-3658 JJ denotes synaptic
T1563 3659-3666 NNS denotes endings
T1564 3667-3671 WDT denotes that
T1565 3672-3676 VBP denotes make
T1566 3677-3684 NN denotes contact
T1567 3685-3689 IN denotes with
T1568 3690-3693 DT denotes the
T1569 3694-3703 NNS denotes processes
T1570 3704-3706 IN denotes of
T1571 3707-3717 JJ denotes horizontal
T1572 3730-3735 NNS denotes cells
T1573 3718-3721 CC denotes and
T1574 3722-3729 JJ denotes bipolar
T1575 3736-3737 -LRB- denotes [
T1576 3740-3742 CD denotes 32
T1577 3737-3739 CD denotes 31
T1578 3739-3740 , denotes ,
T1579 3742-3743 -RRB- denotes ]
T1580 3743-3744 . denotes .
T1581 3744-3859 sentence denotes Rod spherules establish an invaginating synapse with rod bipolar dendrites and axonal endings of horizontal cells.
T1582 3745-3748 NN denotes Rod
T1583 3749-3758 NNS denotes spherules
T1584 3759-3768 VBP denotes establish
T1585 3769-3771 DT denotes an
T1586 3785-3792 NN denotes synapse
T1587 3772-3784 VBG denotes invaginating
T1588 3793-3797 IN denotes with
T1589 3798-3801 NN denotes rod
T1590 3810-3819 NNS denotes dendrites
T1591 3802-3809 JJ denotes bipolar
T1592 3820-3823 CC denotes and
T1593 3824-3830 JJ denotes axonal
T1594 3831-3838 NNS denotes endings
T1595 3839-3841 IN denotes of
T1596 3842-3852 JJ denotes horizontal
T1597 3853-3858 NNS denotes cells
T1598 3858-3859 . denotes .
T1599 3859-3947 sentence denotes This synapse is characterized by the presence of a ribbon in the presynaptic cytoplasm.
T1600 3860-3864 DT denotes This
T1601 3865-3872 NN denotes synapse
T1602 3876-3889 VBN denotes characterized
T1603 3873-3875 VBZ denotes is
T1604 3890-3892 IN denotes by
T1605 3893-3896 DT denotes the
T1606 3897-3905 NN denotes presence
T1607 3906-3908 IN denotes of
T1608 3909-3910 DT denotes a
T1609 3911-3917 NN denotes ribbon
T1610 3918-3920 IN denotes in
T1611 3921-3924 DT denotes the
T1612 3937-3946 NN denotes cytoplasm
T1613 3925-3936 JJ denotes presynaptic
T1614 3946-3947 . denotes .
T1615 3947-4119 sentence denotes Cone pedicles make invaginating synapses with the dendrites of on-cone bipolar cells and horizontal cells and basal junctions with the dendrites of off-cone bipolar cells.
T1616 3948-3952 NN denotes Cone
T1617 3953-3961 NNS denotes pedicles
T1618 3962-3966 VBP denotes make
T1619 3967-3979 VBG denotes invaginating
T1620 3980-3988 NNS denotes synapses
T1621 3989-3993 IN denotes with
T1622 3994-3997 DT denotes the
T1623 3998-4007 NNS denotes dendrites
T1624 4008-4010 IN denotes of
T1625 4011-4013 IN denotes on
T1626 4027-4032 NNS denotes cells
T1627 4013-4014 HYPH denotes -
T1628 4014-4018 NN denotes cone
T1629 4019-4026 JJ denotes bipolar
T1630 4033-4036 CC denotes and
T1631 4037-4047 JJ denotes horizontal
T1632 4048-4053 NNS denotes cells
T1633 4054-4057 CC denotes and
T1634 4058-4063 JJ denotes basal
T1635 4064-4073 NNS denotes junctions
T1636 4074-4078 IN denotes with
T1637 4079-4082 DT denotes the
T1638 4083-4092 NNS denotes dendrites
T1639 4093-4095 IN denotes of
T1640 4096-4099 IN denotes off
T1641 4113-4118 NNS denotes cells
T1642 4099-4100 HYPH denotes -
T1643 4100-4104 NN denotes cone
T1644 4105-4112 JJ denotes bipolar
T1645 4118-4119 . denotes .
T1646 4119-4210 sentence denotes The factors regulating the formation of the photoreceptor synapses are completely unknown.
T1647 4120-4123 DT denotes The
T1648 4124-4131 NNS denotes factors
T1649 4187-4190 VBP denotes are
T1650 4132-4142 VBG denotes regulating
T1651 4143-4146 DT denotes the
T1652 4147-4156 NN denotes formation
T1653 4157-4159 IN denotes of
T1654 4160-4163 DT denotes the
T1655 4178-4186 NNS denotes synapses
T1656 4164-4177 NN denotes photoreceptor
T1657 4191-4201 RB denotes completely
T1658 4202-4209 JJ denotes unknown
T1659 4209-4210 . denotes .
T1660 4210-4351 sentence denotes At least one photoreceptor synaptic protein, HRG4, contains a potential Crx target sequence in its transcriptional regulatory sequence [33].
T1661 4211-4213 RB denotes At
T1662 4220-4223 CD denotes one
T1663 4214-4219 RBS denotes least
T1664 4247-4254 NN denotes protein
T1665 4224-4237 NN denotes photoreceptor
T1666 4238-4246 JJ denotes synaptic
T1667 4262-4270 VBZ denotes contains
T1668 4254-4256 , denotes ,
T1669 4256-4260 NN denotes HRG4
T1670 4260-4262 , denotes ,
T1671 4271-4272 DT denotes a
T1672 4294-4302 NN denotes sequence
T1673 4273-4282 JJ denotes potential
T1674 4283-4286 NN denotes Crx
T1675 4287-4293 NN denotes target
T1676 4303-4305 IN denotes in
T1677 4306-4309 PRP$ denotes its
T1678 4337-4345 NN denotes sequence
T1679 4310-4325 JJ denotes transcriptional
T1680 4326-4336 JJ denotes regulatory
T1681 4346-4347 -LRB- denotes [
T1682 4347-4349 CD denotes 33
T1683 4349-4350 -RRB- denotes ]
T1684 4350-4351 . denotes .
T1685 4351-4467 sentence denotes Few studies of LCA animal models have extended their examination of retinal pathology to the ultrastructural level.
T1686 4352-4355 JJ denotes Few
T1687 4356-4363 NNS denotes studies
T1688 4390-4398 VBN denotes extended
T1689 4364-4366 IN denotes of
T1690 4367-4370 NN denotes LCA
T1691 4378-4384 NNS denotes models
T1692 4371-4377 NN denotes animal
T1693 4385-4389 VBP denotes have
T1694 4399-4404 PRP$ denotes their
T1695 4405-4416 NN denotes examination
T1696 4417-4419 IN denotes of
T1697 4420-4427 JJ denotes retinal
T1698 4428-4437 NN denotes pathology
T1699 4438-4440 IN denotes to
T1700 4441-4444 DT denotes the
T1701 4461-4466 NN denotes level
T1702 4445-4460 JJ denotes ultrastructural
T1703 4466-4467 . denotes .
T1704 4467-4596 sentence denotes Certain features of neuronal differentiation, such as synapse formation, can be detected definitively at this level of analysis.
T1705 4468-4475 JJ denotes Certain
T1706 4476-4484 NNS denotes features
T1707 4548-4556 VBN denotes detected
T1708 4485-4487 IN denotes of
T1709 4488-4496 JJ denotes neuronal
T1710 4497-4512 NN denotes differentiation
T1711 4512-4514 , denotes ,
T1712 4514-4518 JJ denotes such
T1713 4519-4521 IN denotes as
T1714 4522-4529 NN denotes synapse
T1715 4530-4539 NN denotes formation
T1716 4539-4541 , denotes ,
T1717 4541-4544 MD denotes can
T1718 4545-4547 VB denotes be
T1719 4557-4569 RB denotes definitively
T1720 4570-4572 IN denotes at
T1721 4573-4577 DT denotes this
T1722 4578-4583 NN denotes level
T1723 4584-4586 IN denotes of
T1724 4587-4595 NN denotes analysis
T1725 4595-4596 . denotes .
T1726 4596-4774 sentence denotes With the hope of understanding the neuropathology of LCA in greater detail, we have analyzed the differentiation of the outer retina in Crx-/- mice at the ultrastructural level.
T1727 4597-4601 IN denotes With
T1728 4681-4689 VBN denotes analyzed
T1729 4602-4605 DT denotes the
T1730 4606-4610 NN denotes hope
T1731 4611-4613 IN denotes of
T1732 4614-4627 VBG denotes understanding
T1733 4628-4631 DT denotes the
T1734 4632-4646 NN denotes neuropathology
T1735 4647-4649 IN denotes of
T1736 4650-4653 NN denotes LCA
T1737 4654-4656 IN denotes in
T1738 4657-4664 JJR denotes greater
T1739 4665-4671 NN denotes detail
T1740 4671-4673 , denotes ,
T1741 4673-4675 PRP denotes we
T1742 4676-4680 VBP denotes have
T1743 4690-4693 DT denotes the
T1744 4694-4709 NN denotes differentiation
T1745 4710-4712 IN denotes of
T1746 4713-4716 DT denotes the
T1747 4723-4729 NN denotes retina
T1748 4717-4722 JJ denotes outer
T1749 4730-4732 IN denotes in
T1750 4733-4736 NN denotes Crx
T1751 4740-4744 NNS denotes mice
T1752 4736-4737 SYM denotes -
T1753 4737-4738 HYPH denotes /
T1754 4738-4739 SYM denotes -
T1755 4745-4747 IN denotes at
T1756 4748-4751 DT denotes the
T1757 4768-4773 NN denotes level
T1758 4752-4767 JJ denotes ultrastructural
T1759 4773-4774 . denotes .
T1760 4774-4823 sentence denotes These retinas exhibit several prominent defects.
T1761 4775-4780 DT denotes These
T1762 4781-4788 NNS denotes retinas
T1763 4789-4796 VBP denotes exhibit
T1764 4797-4804 JJ denotes several
T1765 4815-4822 NNS denotes defects
T1766 4805-4814 JJ denotes prominent
T1767 4822-4823 . denotes .
T1768 4823-4926 sentence denotes Crx-/- photoreceptors demonstrate a complete block in outer segment formation at the elongation stage.
T1769 4824-4827 NN denotes Crx
T1770 4831-4845 NNS denotes photoreceptors
T1771 4827-4828 SYM denotes -
T1772 4828-4829 HYPH denotes /
T1773 4829-4830 SYM denotes -
T1774 4846-4857 VBP denotes demonstrate
T1775 4858-4859 DT denotes a
T1776 4869-4874 NN denotes block
T1777 4860-4868 JJ denotes complete
T1778 4875-4877 IN denotes in
T1779 4878-4883 JJ denotes outer
T1780 4884-4891 NN denotes segment
T1781 4892-4901 NN denotes formation
T1782 4902-4904 IN denotes at
T1783 4905-4908 DT denotes the
T1784 4920-4925 NN denotes stage
T1785 4909-4919 NN denotes elongation
T1786 4925-4926 . denotes .
T1787 4926-5057 sentence denotes Further, these cells exhibit abnormal synaptic morphology, thereby broadening the function of Crx to photoreceptor synaptogenesis.
T1788 4927-4934 RB denotes Further
T1789 4948-4955 VBP denotes exhibit
T1790 4934-4936 , denotes ,
T1791 4936-4941 DT denotes these
T1792 4942-4947 NNS denotes cells
T1793 4956-4964 JJ denotes abnormal
T1794 4974-4984 NN denotes morphology
T1795 4965-4973 JJ denotes synaptic
T1796 4984-4986 , denotes ,
T1797 4986-4993 RB denotes thereby
T1798 4994-5004 VBG denotes broadening
T1799 5005-5008 DT denotes the
T1800 5009-5017 NN denotes function
T1801 5018-5020 IN denotes of
T1802 5021-5024 NN denotes Crx
T1803 5025-5027 IN denotes to
T1804 5028-5041 NN denotes photoreceptor
T1805 5042-5056 NN denotes synaptogenesis
T1806 5056-5057 . denotes .
T1807 5057-5152 sentence denotes This represents the first report strongly implicating the process of synapse formation in LCA.
T1808 5058-5062 DT denotes This
T1809 5063-5073 VBZ denotes represents
T1810 5074-5077 DT denotes the
T1811 5084-5090 NN denotes report
T1812 5078-5083 JJ denotes first
T1813 5091-5099 RB denotes strongly
T1814 5100-5111 VBG denotes implicating
T1815 5112-5115 DT denotes the
T1816 5116-5123 NN denotes process
T1817 5124-5126 IN denotes of
T1818 5127-5134 NN denotes synapse
T1819 5135-5144 NN denotes formation
T1820 5145-5147 IN denotes in
T1821 5148-5151 NN denotes LCA
T1822 5151-5152 . denotes .
R220 T822 T823 compound Photoreceptor,cells
R221 T823 T824 nsubj cells,play
R222 T825 T826 det a,role
R223 T826 T824 dobj role,play
R224 T827 T826 amod primary,role
R225 T828 T824 prep in,play
R226 T829 T828 pobj vision,in
R227 T830 T824 prep by,play
R228 T831 T830 pcomp capturing,by
R229 T832 T833 compound light,energy
R230 T833 T831 dobj energy,capturing
R231 T834 T831 cc and,capturing
R232 T835 T831 conj converting,capturing
R233 T836 T835 dobj it,converting
R234 T837 T835 prep into,converting
R235 T838 T839 amod neural,stimuli
R236 T839 T837 pobj stimuli,into
R237 T840 T824 punct .,play
R238 T842 T843 det These,neurons
R239 T843 T845 nsubj neurons,are
R240 T844 T843 amod sensory,neurons
R241 T846 T847 det a,element
R242 T847 T845 attr element,are
R243 T848 T847 amod shared,element
R244 T849 T845 prep in,are
R245 T850 T851 det all,organisms
R246 T851 T849 pobj organisms,in
R247 T852 T851 amod capable,organisms
R248 T853 T852 prep of,capable
R249 T854 T853 pcomp sensing,of
R250 T855 T854 dobj light,sensing
R251 T856 T845 punct .,are
R252 T858 T859 prep In,are
R253 T860 T858 pobj humans,In
R254 T861 T859 punct ", ",are
R255 T862 T863 amod genetic,diseases
R256 T863 T859 nsubj diseases,are
R257 T864 T863 prep of,diseases
R258 T865 T866 det the,eye
R259 T866 T864 pobj eye,of
R260 T867 T859 acomp common,are
R261 T868 T859 cc and,are
R262 T869 T870 det the,site
R263 T870 T872 nsubj site,is
R264 T871 T870 amod primary,site
R265 T872 T859 conj is,are
R266 T873 T870 prep of,site
R267 T874 T873 pobj disease,of
R268 T875 T876 advmod most,frequently
R269 T876 T872 advmod frequently,is
R270 T877 T872 attr photoreceptors,is
R271 T878 T879 punct (,see
R272 T879 T872 parataxis see,is
R273 T880 T879 prep for,see
R274 T881 T880 pobj review,for
R275 T882 T879 punct [,see
R276 T883 T879 dobj 1,see
R277 T884 T885 punct -,3
R278 T885 T883 prep 3,1
R279 T886 T879 punct ],see
R280 T887 T879 punct ),see
R281 T888 T859 punct .,are
R282 T890 T891 nsubjpass Photoreceptors,studied
R283 T892 T891 aux have,studied
R284 T893 T891 auxpass been,studied
R285 T894 T891 advmod well,studied
R286 T895 T891 punct ", ",studied
R287 T896 T897 advmod particularly,with
R288 T897 T891 prep with,studied
R289 T898 T897 pobj respect,with
R290 T899 T898 prep to,respect
R291 T900 T901 det the,biochemistry
R292 T901 T899 pobj biochemistry,to
R293 T902 T901 cc and,biochemistry
R294 T903 T901 conj physiology,biochemistry
R295 T904 T901 prep of,biochemistry
R296 T905 T904 pobj phototransduction,of
R297 T906 T891 punct .,studied
R298 T908 T909 nsubj Insight,lagged
R299 T910 T908 prep into,Insight
R300 T911 T912 det the,development
R301 T912 T910 pobj development,into
R302 T913 T912 prep of,development
R303 T914 T915 compound vertebrate,photoreceptors
R304 T915 T913 pobj photoreceptors,of
R305 T916 T909 punct ", ",lagged
R306 T917 T909 advmod however,lagged
R307 T918 T909 punct ", ",lagged
R308 T919 T909 aux has,lagged
R309 T920 T909 prep behind,lagged
R310 T921 T922 poss our,understanding
R311 T922 T920 pobj understanding,behind
R312 T923 T922 prep of,understanding
R313 T924 T923 pobj function,of
R314 T925 T909 punct .,lagged
R315 T927 T928 advmod Only,recently
R316 T928 T929 advmod recently,identified
R317 T930 T929 aux have,identified
R318 T931 T932 det the,mechanisms
R319 T932 T929 nsubjpass mechanisms,identified
R320 T933 T932 amod first,mechanisms
R321 T934 T932 amod molecular,mechanisms
R322 T935 T932 acl regulating,mechanisms
R323 T936 T937 compound photoreceptor,development
R324 T937 T935 dobj development,regulating
R325 T938 T929 auxpass been,identified
R326 T939 T940 punct (,see
R327 T940 T929 parataxis see,identified
R328 T941 T940 prep for,see
R329 T942 T941 pobj review,for
R330 T943 T940 punct ", ",see
R331 T944 T940 punct [,see
R332 T945 T946 nummod 2,4
R333 T946 T940 dobj 4,see
R334 T947 T946 punct ",",4
R335 T948 T940 punct ],see
R336 T949 T940 punct ),see
R337 T950 T929 punct .,identified
R338 T952 T953 nsubj Crx,is
R339 T954 T952 punct (,Crx
R340 T955 T956 compound cone,rod
R341 T956 T958 compound rod,homeobox
R342 T957 T956 punct -,rod
R343 T958 T952 appos homeobox,Crx
R344 T959 T953 punct ),is
R345 T960 T961 det an,gene
R346 T961 T953 attr gene,is
R347 T962 T963 compound otx,family
R348 T963 T965 compound family,homeobox
R349 T964 T963 punct -,family
R350 T965 T961 compound homeobox,gene
R351 T966 T961 acl expressed,gene
R352 T967 T966 advmod predominantly,expressed
R353 T968 T966 prep in,expressed
R354 T969 T968 pobj photoreceptors,in
R355 T970 T966 punct ", ",expressed
R356 T971 T966 prep from,expressed
R357 T972 T971 pcomp early,from
R358 T973 T972 prep in,early
R359 T974 T975 poss their,development
R360 T975 T973 pobj development,in
R361 T976 T971 prep through,from
R362 T977 T976 prep to,through
R363 T978 T979 det the,ages
R364 T979 T977 pobj ages,to
R365 T980 T979 amod adult,ages
R366 T981 T982 punct [,5
R367 T982 T966 parataxis 5,expressed
R368 T983 T984 punct -,7
R369 T984 T982 prep 7,5
R370 T985 T982 punct ],5
R371 T986 T953 punct .,is
R372 T988 T989 compound Crx,expression
R373 T989 T991 nsubj expression,is
R374 T990 T989 compound gene,expression
R375 T992 T993 advmod critically,dependent
R376 T993 T991 acomp dependent,is
R377 T994 T993 prep upon,dependent
R378 T995 T994 pobj Otx2,upon
R379 T996 T995 punct ", ",Otx2
R380 T997 T998 det another,member
R381 T998 T995 appos member,Otx2
R382 T999 T998 prep of,member
R383 T1000 T1001 det the,family
R384 T1001 T999 pobj family,of
R385 T1002 T1001 amod same,family
R386 T1003 T1001 compound homeobox,family
R387 T1004 T1005 dep which,expressed
R388 T1005 T998 relcl expressed,member
R389 T1006 T1005 auxpass is,expressed
R390 T1007 T1005 prep in,expressed
R391 T1008 T1009 amod early,cells
R392 T1009 T1007 pobj cells,in
R393 T1010 T1009 compound photoreceptor,cells
R394 T1011 T1012 punct [,8
R395 T1012 T991 parataxis 8,is
R396 T1013 T1012 punct ],8
R397 T1014 T991 punct .,is
R398 T1016 T1017 prep In,appears
R399 T1018 T1019 compound rod,photoreceptors
R400 T1019 T1016 pobj photoreceptors,In
R401 T1020 T1017 punct ", ",appears
R402 T1021 T1017 nsubj Crx,appears
R403 T1022 T1023 aux to,work
R404 T1023 T1017 xcomp work,appears
R405 T1024 T1023 prep in,work
R406 T1025 T1024 pobj concert,in
R407 T1026 T1025 prep with,concert
R408 T1027 T1026 pobj Nrl,with
R409 T1028 T1027 punct ", ",Nrl
R410 T1029 T1030 det a,protein
R411 T1030 T1027 appos protein,Nrl
R412 T1031 T1032 compound leucine,zipper
R413 T1032 T1030 compound zipper,protein
R414 T1033 T1034 dep that,restricted
R415 T1034 T1030 relcl restricted,protein
R416 T1035 T1034 auxpass is,restricted
R417 T1036 T1034 advmod also,restricted
R418 T1037 T1034 prep in,restricted
R419 T1038 T1039 poss its,expression
R420 T1039 T1037 pobj expression,in
R421 T1040 T1039 prep in,expression
R422 T1041 T1042 det the,retina
R423 T1042 T1040 pobj retina,in
R424 T1043 T1034 prep to,restricted
R425 T1044 T1045 compound rod,photoreceptors
R426 T1045 T1043 pobj photoreceptors,to
R427 T1046 T1047 punct [,9
R428 T1047 T1034 parataxis 9,restricted
R429 T1048 T1047 punct ],9
R430 T1049 T1017 punct .,appears
R431 T1051 T1052 amod Many,genes
R432 T1052 T1056 nsubj genes,have
R433 T1053 T1054 npadvmod photoreceptor,specific
R434 T1054 T1052 amod specific,genes
R435 T1055 T1054 punct -,specific
R436 T1057 T1058 amod putative,elements
R437 T1058 T1056 dobj elements,have
R438 T1059 T1060 npadvmod Crx,binding
R439 T1060 T1058 amod binding,elements
R440 T1061 T1060 punct -,binding
R441 T1062 T1056 prep in,have
R442 T1063 T1064 poss their,regions
R443 T1064 T1062 pobj regions,in
R444 T1065 T1064 amod regulatory,regions
R445 T1066 T1067 punct [,10
R446 T1067 T1056 parataxis 10,have
R447 T1068 T1067 punct ],10
R448 T1069 T1056 punct ", ",have
R449 T1070 T1056 prep including,have
R450 T1071 T1070 pobj rhodopsin,including
R451 T1072 T1073 punct [,11
R452 T1073 T1071 parataxis 11,rhodopsin
R453 T1074 T1073 punct ],11
R454 T1075 T1071 cc and,rhodopsin
R455 T1076 T1071 conj arrestin,rhodopsin
R456 T1077 T1078 punct [,12
R457 T1078 T1076 parataxis 12,arrestin
R458 T1079 T1078 punct ],12
R459 T1080 T1056 punct .,have
R460 T1082 T1083 nsubjpass Mutations,associated
R461 T1084 T1082 prep in,Mutations
R462 T1085 T1084 pobj Crx,in
R463 T1086 T1083 aux have,associated
R464 T1087 T1083 auxpass been,associated
R465 T1088 T1083 prep with,associated
R466 T1089 T1090 amod several,diseases
R467 T1090 T1088 pobj diseases,with
R468 T1091 T1090 amod human,diseases
R469 T1092 T1093 dep that,lead
R470 T1093 T1090 relcl lead,diseases
R471 T1094 T1093 prep to,lead
R472 T1095 T1094 pobj blindness,to
R473 T1096 T1090 punct ", ",diseases
R474 T1097 T1090 prep including,diseases
R475 T1098 T1099 compound cone,rod
R476 T1099 T1101 compound rod,dystrophy
R477 T1100 T1099 punct -,rod
R478 T1101 T1097 pobj dystrophy,including
R479 T1102 T1101 nummod 2,dystrophy
R480 T1103 T1104 punct [,14
R481 T1104 T1101 parataxis 14,dystrophy
R482 T1105 T1104 nummod 6,14
R483 T1106 T1104 punct ",",14
R484 T1107 T1104 nummod 13,14
R485 T1108 T1104 punct ",",14
R486 T1109 T1104 punct ],14
R487 T1110 T1101 punct ", ",dystrophy
R488 T1111 T1112 compound retinitis,pigmentosa
R489 T1112 T1101 conj pigmentosa,dystrophy
R490 T1113 T1114 punct [,14
R491 T1114 T1112 parataxis 14,pigmentosa
R492 T1115 T1114 punct ],14
R493 T1116 T1112 punct ", ",pigmentosa
R494 T1117 T1112 cc and,pigmentosa
R495 T1118 T1112 conj LCA,pigmentosa
R496 T1119 T1120 punct [,14
R497 T1120 T1118 parataxis 14,LCA
R498 T1121 T1122 punct -,16
R499 T1122 T1120 prep 16,14
R500 T1123 T1120 punct ],14
R501 T1124 T1083 punct .,associated
R502 T1126 T1127 prep Based,hypothesized
R503 T1128 T1126 prep on,Based
R504 T1129 T1130 det these,data
R505 T1130 T1128 pobj data,on
R506 T1131 T1127 punct ", ",hypothesized
R507 T1132 T1127 nsubjpass Crx,hypothesized
R508 T1133 T1127 auxpass was,hypothesized
R509 T1134 T1135 aux to,play
R510 T1135 T1127 xcomp play,hypothesized
R511 T1136 T1137 det a,role
R512 T1137 T1135 dobj role,play
R513 T1138 T1137 amod critical,role
R514 T1139 T1135 prep in,play
R515 T1140 T1141 det the,differentiation
R516 T1141 T1139 pobj differentiation,in
R517 T1142 T1141 cc and,differentiation
R518 T1143 T1141 conj maintainance,differentiation
R519 T1144 T1141 prep of,differentiation
R520 T1145 T1146 compound photoreceptor,cells
R521 T1146 T1144 pobj cells,of
R522 T1147 T1148 punct [,7
R523 T1148 T1135 parataxis 7,play
R524 T1149 T1148 nummod 5,7
R525 T1150 T1148 punct ",",7
R526 T1151 T1148 punct ],7
R527 T1152 T1127 punct .,hypothesized
R528 T1154 T1155 nsubj LCA,is
R529 T1156 T1157 det the,disease
R530 T1157 T1155 attr disease,is
R531 T1158 T1159 advmod most,severe
R532 T1159 T1157 amod severe,disease
R533 T1160 T1157 amod genetic,disease
R534 T1161 T1157 prep of,disease
R535 T1162 T1161 pobj photoreceptors,of
R536 T1163 T1164 punct (,see
R537 T1164 T1155 parataxis see,is
R538 T1165 T1164 punct [,see
R539 T1166 T1164 dobj 17,see
R540 T1167 T1164 punct ],see
R541 T1168 T1164 punct ", ",see
R542 T1169 T1164 prep for,see
R543 T1170 T1171 amod recent,review
R544 T1171 T1169 pobj review,for
R545 T1172 T1164 punct ),see
R546 T1173 T1155 punct .,is
R547 T1175 T1176 amod Affected,infants
R548 T1176 T1177 nsubj infants,exhibit
R549 T1178 T1179 det a,absence
R550 T1179 T1177 dobj absence,exhibit
R551 T1180 T1179 amod complete,absence
R552 T1181 T1180 cc or,complete
R553 T1182 T1183 advmod near,complete
R554 T1183 T1180 conj complete,complete
R555 T1184 T1179 prep of,absence
R556 T1185 T1184 pobj vision,of
R557 T1186 T1177 prep from,exhibit
R558 T1187 T1186 pobj birth,from
R559 T1188 T1177 punct .,exhibit
R560 T1190 T1191 nsubjpass Mutations,associated
R561 T1192 T1190 prep in,Mutations
R562 T1193 T1194 npadvmod retinal,specific
R563 T1194 T1195 amod specific,genes
R564 T1195 T1192 pobj genes,in
R565 T1196 T1195 punct ", ",genes
R566 T1197 T1198 amod such,as
R567 T1198 T1195 prep as,genes
R568 T1199 T1198 pobj Crx,as
R569 T1200 T1191 punct ", ",associated
R570 T1201 T1191 aux have,associated
R571 T1202 T1191 auxpass been,associated
R572 T1203 T1191 prep with,associated
R573 T1204 T1203 pobj LCA,with
R574 T1205 T1206 punct [,15
R575 T1206 T1204 parataxis 15,LCA
R576 T1207 T1206 nummod 14,15
R577 T1208 T1206 punct ",",15
R578 T1209 T1206 punct ],15
R579 T1210 T1204 punct ", ",LCA
R580 T1211 T1212 advmod as,as
R581 T1212 T1204 cc as,LCA
R582 T1213 T1212 advmod well,as
R583 T1214 T1204 conj GUCY2D,LCA
R584 T1215 T1216 punct [,18
R585 T1216 T1214 parataxis 18,GUCY2D
R586 T1217 T1216 punct ],18
R587 T1218 T1214 punct ", ",GUCY2D
R588 T1219 T1214 conj RPE65,GUCY2D
R589 T1220 T1221 punct [,19
R590 T1221 T1219 parataxis 19,RPE65
R591 T1222 T1221 punct ],19
R592 T1223 T1219 punct ", ",RPE65
R593 T1224 T1219 conj AIPL,RPE65
R594 T1225 T1224 punct -,AIPL
R595 T1226 T1224 nummod 1,AIPL
R596 T1227 T1228 punct [,20
R597 T1228 T1224 parataxis 20,AIPL
R598 T1229 T1228 punct ],20
R599 T1230 T1224 punct ", ",AIPL
R600 T1231 T1224 conj CRB,AIPL
R601 T1232 T1231 punct -,CRB
R602 T1233 T1231 nummod 1,CRB
R603 T1234 T1235 punct [,21
R604 T1235 T1231 parataxis 21,CRB
R605 T1236 T1235 punct ],21
R606 T1237 T1231 punct ", ",CRB
R607 T1238 T1231 cc and,CRB
R608 T1239 T1231 conj RPGRIP,CRB
R609 T1240 T1239 punct -,RPGRIP
R610 T1241 T1239 nummod 1,RPGRIP
R611 T1242 T1243 punct [,22
R612 T1243 T1239 parataxis 22,RPGRIP
R613 T1244 T1243 punct ],22
R614 T1245 T1191 punct .,associated
R615 T1247 T1248 expl There,be
R616 T1249 T1248 advmod also,be
R617 T1250 T1248 aux may,be
R618 T1251 T1252 advmod as,three
R619 T1252 T1255 nummod three,loci
R620 T1253 T1252 amod many,three
R621 T1254 T1252 quantmod as,three
R622 T1255 T1248 attr loci,be
R623 T1256 T1255 amod additional,loci
R624 T1257 T1258 advmod genetically,linked
R625 T1258 T1255 amod linked,loci
R626 T1259 T1260 advmod where,identified
R627 T1260 T1255 relcl identified,loci
R628 T1261 T1260 nsubjpass genes,identified
R629 T1262 T1260 aux have,identified
R630 T1263 T1260 neg not,identified
R631 T1264 T1260 auxpass been,identified
R632 T1265 T1266 punct [,23
R633 T1266 T1255 parataxis 23,loci
R634 T1267 T1266 punct ],23
R635 T1268 T1248 punct .,be
R636 T1270 T1271 compound Crx,mutations
R637 T1271 T1272 nsubj mutations,are
R638 T1273 T1271 prep in,mutations
R639 T1274 T1273 pobj LCA,in
R640 T1275 T1272 acomp varied,are
R641 T1276 T1272 punct ", ",are
R642 T1277 T1272 cc and,are
R643 T1278 T1272 conj include,are
R644 T1279 T1280 det a,mutation
R645 T1280 T1278 dobj mutation,include
R646 T1281 T1280 amod putative,mutation
R647 T1282 T1280 amod dominant,mutation
R648 T1283 T1284 dep that,proposed
R649 T1284 T1280 relcl proposed,mutation
R650 T1285 T1284 auxpass is,proposed
R651 T1286 T1287 aux to,encode
R652 T1287 T1284 xcomp encode,proposed
R653 T1288 T1289 det a,form
R654 T1289 T1287 dobj form,encode
R655 T1290 T1291 amod dominant,negative
R656 T1291 T1289 nmod negative,form
R657 T1292 T1291 punct -,negative
R658 T1293 T1289 prep of,form
R659 T1294 T1293 pobj Crx,of
R660 T1295 T1296 punct [,15
R661 T1296 T1287 parataxis 15,encode
R662 T1297 T1296 nummod 14,15
R663 T1298 T1296 punct ",",15
R664 T1299 T1296 punct ],15
R665 T1300 T1272 punct .,are
R666 T1302 T1303 amod Recessive,mutations
R667 T1303 T1304 nsubjpass mutations,reported
R668 T1305 T1304 advmod also,reported
R669 T1306 T1304 aux have,reported
R670 T1307 T1304 auxpass been,reported
R671 T1308 T1304 cc and,reported
R672 T1309 T1310 advmod at,one
R673 T1310 T1312 nummod one,allele
R674 T1311 T1310 advmod least,one
R675 T1312 T1313 nsubj allele,encodes
R676 T1313 T1304 conj encodes,reported
R677 T1314 T1315 det a,protein
R678 T1315 T1313 dobj protein,encodes
R679 T1316 T1315 prep with,protein
R680 T1317 T1318 amod decreased,activity
R681 T1318 T1316 pobj activity,with
R682 T1319 T1318 nmod DNA,activity
R683 T1320 T1319 punct -,DNA
R684 T1321 T1319 amod binding,DNA
R685 T1322 T1323 punct [,16
R686 T1323 T1313 parataxis 16,encodes
R687 T1324 T1323 punct ],16
R688 T1325 T1313 punct .,encodes
R689 T1327 T1328 amod Histopathological,studies
R690 T1328 T1331 nsubj studies,enable
R691 T1329 T1327 cc and,Histopathological
R692 T1330 T1327 conj ultrastructural,Histopathological
R693 T1332 T1328 prep of,studies
R694 T1333 T1332 pobj LCA,of
R695 T1334 T1331 aux should,enable
R696 T1335 T1336 det a,understanding
R697 T1336 T1331 dobj understanding,enable
R698 T1337 T1336 amod better,understanding
R699 T1338 T1336 prep of,understanding
R700 T1339 T1340 det the,process
R701 T1340 T1338 pobj process,of
R702 T1341 T1340 compound disease,process
R703 T1342 T1336 punct ", ",understanding
R704 T1343 T1336 cc and,understanding
R705 T1344 T1345 det the,design
R706 T1345 T1336 conj design,understanding
R707 T1346 T1345 prep of,design
R708 T1347 T1348 amod suitable,therapies
R709 T1348 T1346 pobj therapies,of
R710 T1349 T1331 punct .,enable
R711 T1351 T1352 amod Few,studies
R712 T1352 T1354 nsubj studies,exist
R713 T1353 T1352 amod such,studies
R714 T1355 T1354 prep for,exist
R715 T1356 T1357 amod human,LCA
R716 T1357 T1355 pobj LCA,for
R717 T1358 T1359 punct (,reviewed
R718 T1359 T1354 parataxis reviewed,exist
R719 T1360 T1359 prep in,reviewed
R720 T1361 T1360 punct [,in
R721 T1362 T1360 pobj 17,in
R722 T1363 T1359 punct ],reviewed
R723 T1364 T1359 punct ),reviewed
R724 T1365 T1354 cc and,exist
R725 T1366 T1367 det the,majority
R726 T1367 T1368 nsubj majority,examine
R727 T1368 T1354 conj examine,exist
R728 T1369 T1367 prep of,majority
R729 T1370 T1371 amod such,studies
R730 T1371 T1369 pobj studies,of
R731 T1372 T1373 det the,globes
R732 T1373 T1368 dobj globes,examine
R733 T1374 T1373 prep of,globes
R734 T1375 T1374 pobj adults,of
R735 T1376 T1375 prep with,adults
R736 T1377 T1376 pobj LCA,with
R737 T1378 T1368 punct ", ",examine
R738 T1379 T1380 mark after,undergone
R739 T1380 T1368 advcl undergone,examine
R740 T1381 T1382 det the,tissue
R741 T1382 T1380 nsubj tissue,undergone
R742 T1383 T1380 aux has,undergone
R743 T1384 T1385 amod secondary,changes
R744 T1385 T1380 dobj changes,undergone
R745 T1386 T1368 punct .,examine
R746 T1388 T1389 advmod Only,study
R747 T1389 T1392 nsubj study,exists
R748 T1390 T1389 det a,study
R749 T1391 T1389 amod single,study
R750 T1393 T1394 advmod where,examined
R751 T1394 T1392 ccomp examined,exists
R752 T1395 T1396 det the,eye
R753 T1396 T1394 nsubjpass eye,examined
R754 T1397 T1396 amod developing,eye
R755 T1398 T1396 prep of,eye
R756 T1399 T1400 det an,infant
R757 T1400 T1398 pobj infant,of
R758 T1401 T1394 auxpass was,examined
R759 T1402 T1403 punct [,24
R760 T1403 T1394 parataxis 24,examined
R761 T1404 T1403 punct ],24
R762 T1405 T1392 punct .,exists
R763 T1407 T1408 compound Animal,models
R764 T1408 T1409 nsubjpass models,reported
R765 T1410 T1408 prep for,models
R766 T1411 T1410 pobj LCA,for
R767 T1412 T1409 aux have,reported
R768 T1413 T1409 advmod recently,reported
R769 T1414 T1409 auxpass been,reported
R770 T1415 T1409 cc and,reported
R771 T1416 T1417 aux have,served
R772 T1417 T1409 conj served,reported
R773 T1418 T1417 advmod already,served
R774 T1419 T1420 aux to,broaden
R775 T1420 T1417 xcomp broaden,served
R776 T1421 T1422 poss our,understanding
R777 T1422 T1420 dobj understanding,broaden
R778 T1423 T1422 prep of,understanding
R779 T1424 T1425 det the,pathology
R780 T1425 T1423 pobj pathology,of
R781 T1426 T1425 prep of,pathology
R782 T1427 T1428 det this,disease
R783 T1428 T1426 pobj disease,of
R784 T1429 T1430 punct [,25
R785 T1430 T1420 parataxis 25,broaden
R786 T1431 T1432 punct -,28
R787 T1432 T1430 prep 28,25
R788 T1433 T1430 punct ],25
R789 T1434 T1409 punct .,reported
R790 T1436 T1437 mark Since,is
R791 T1437 T1439 advcl is,are
R792 T1438 T1437 nsubj LCA,is
R793 T1440 T1441 det a,disorder
R794 T1441 T1437 attr disorder,is
R795 T1442 T1443 advmod clinically,heterogeneous
R796 T1443 T1441 amod heterogeneous,disorder
R797 T1444 T1442 cc and,clinically
R798 T1445 T1442 conj genetically,clinically
R799 T1446 T1439 punct ", ",are
R800 T1447 T1448 amod additional,models
R801 T1448 T1439 nsubj models,are
R802 T1449 T1448 compound mouse,models
R803 T1450 T1439 prep in,are
R804 T1451 T1450 pobj order,in
R805 T1452 T1453 aux to,allow
R806 T1453 T1439 advcl allow,are
R807 T1454 T1455 det a,understanding
R808 T1455 T1453 dobj understanding,allow
R809 T1456 T1455 amod full,understanding
R810 T1457 T1455 prep of,understanding
R811 T1458 T1459 det the,ways
R812 T1459 T1457 pobj ways,of
R813 T1460 T1459 amod many,ways
R814 T1461 T1462 prep in,go
R815 T1462 T1459 relcl go,ways
R816 T1463 T1461 pobj which,in
R817 T1464 T1465 compound photoreceptor,development
R818 T1465 T1462 nsubj development,go
R819 T1466 T1462 aux can,go
R820 T1483 T1471 nsubj cells,serve
R821 T1467 T1462 advcl awry,go
R822 T1484 T1471 prep as,serve
R823 T1468 T1439 punct .,are
R824 T1485 T1486 det an,model
R825 T1486 T1484 pobj model,as
R826 T1470 T1471 prep In,serve
R827 T1487 T1486 amod excellent,model
R828 T1488 T1486 prep for,model
R829 T1489 T1488 pobj studies,for
R830 T1490 T1489 prep in,studies
R831 T1491 T1492 amod neuronal,differentiation
R832 T1492 T1490 pobj differentiation,in
R833 T1493 T1471 punct .,serve
R834 T1472 T1470 pobj addition,In
R835 T1495 T1496 compound Photoreceptor,cells
R836 T1496 T1497 nsubj cells,are
R837 T1473 T1472 prep to,addition
R838 T1498 T1499 advmod highly,polarized
R839 T1499 T1497 acomp polarized,are
R840 T1474 T1475 poss their,importance
R841 T1500 T1497 punct .,are
R842 T1475 T1473 pobj importance,to
R843 T1502 T1503 prep At,have
R844 T1504 T1505 poss their,apex
R845 T1476 T1475 prep as,importance
R846 T1505 T1502 pobj apex,At
R847 T1506 T1503 punct ", ",have
R848 T1477 T1478 det a,locus
R849 T1507 T1508 det these,neurons
R850 T1508 T1503 nsubj neurons,have
R851 T1509 T1510 det a,segment
R852 T1478 T1476 pobj locus,as
R853 T1510 T1503 dobj segment,have
R854 T1511 T1510 amod membranous,segment
R855 T1479 T1478 prep of,locus
R856 T1512 T1510 amod outer,segment
R857 T1480 T1479 pobj disease,of
R858 T1481 T1471 punct ", ",serve
R859 T1513 T1510 punct ", ",segment
R860 T1514 T1515 dep which,contains
R861 T1515 T1510 relcl contains,segment
R862 T1482 T1483 compound photoreceptor,cells
R863 T1516 T1515 dobj proteins,contains
R864 T1589 T1590 nmod rod,dendrites
R865 T1517 T1516 acl involved,proteins
R866 T1518 T1517 prep in,involved
R867 T1519 T1520 det the,cascade
R868 T1520 T1518 pobj cascade,in
R869 T1521 T1520 compound phototransduction,cascade
R870 T1590 T1588 pobj dendrites,with
R871 T1522 T1503 punct .,have
R872 T1591 T1590 amod bipolar,dendrites
R873 T1524 T1525 nmod Loss,mutations
R874 T1525 T1528 nsubj mutations,result
R875 T1592 T1590 cc and,dendrites
R876 T1526 T1524 prep of,Loss
R877 T1527 T1526 pobj function,of
R878 T1593 T1594 amod axonal,endings
R879 T1529 T1525 prep in,mutations
R880 T1530 T1529 pobj rhodopsin,in
R881 T1531 T1532 punct [,29
R882 T1532 T1530 parataxis 29,rhodopsin
R883 T1533 T1532 punct ],29
R884 T1534 T1530 punct ", ",rhodopsin
R885 T1594 T1590 conj endings,dendrites
R886 T1535 T1530 cc or,rhodopsin
R887 T1536 T1537 det the,protein
R888 T1537 T1530 conj protein,rhodopsin
R889 T1538 T1537 amod structural,protein
R890 T1595 T1594 prep of,endings
R891 T1539 T1537 punct ", ",protein
R892 T1540 T1537 appos peripherin,protein
R893 T1596 T1597 amod horizontal,cells
R894 T1541 T1542 punct [,30
R895 T1542 T1540 parataxis 30,peripherin
R896 T1597 T1595 pobj cells,of
R897 T1543 T1542 punct ],30
R898 T1544 T1528 punct ", ",result
R899 T1545 T1528 prep in,result
R900 T1598 T1584 punct .,establish
R901 T1546 T1547 det an,inability
R902 T1547 T1545 pobj inability,in
R903 T1548 T1549 aux to,form
R904 T1600 T1601 det This,synapse
R905 T1549 T1547 acl form,inability
R906 T1550 T1551 amod outer,segments
R907 T1551 T1549 dobj segments,form
R908 T1552 T1528 punct .,result
R909 T1601 T1602 nsubjpass synapse,characterized
R910 T1554 T1555 prep At,terminate
R911 T1556 T1557 det the,extremity
R912 T1603 T1602 auxpass is,characterized
R913 T1557 T1554 pobj extremity,At
R914 T1558 T1557 amod other,extremity
R915 T1559 T1555 punct ", ",terminate
R916 T1604 T1602 agent by,characterized
R917 T1560 T1555 nsubj photoreceptors,terminate
R918 T1561 T1555 prep with,terminate
R919 T1562 T1563 amod synaptic,endings
R920 T1563 T1561 pobj endings,with
R921 T1605 T1606 det the,presence
R922 T1564 T1565 dep that,make
R923 T1565 T1563 relcl make,endings
R924 T1566 T1565 dobj contact,make
R926 T1567 T1565 prep with,make
R927 T1568 T1569 det the,processes
R928 T1569 T1567 pobj processes,with
R929 T1607 T1606 prep of,presence
R930 T1570 T1569 prep of,processes
R931 T1571 T1572 amod horizontal,cells
R932 T1572 T1570 pobj cells,of
R933 T1573 T1571 cc and,horizontal
R934 T1574 T1571 conj bipolar,horizontal
R935 T1575 T1576 punct [,32
R936 T1608 T1609 det a,ribbon
R937 T1576 T1565 parataxis 32,make
R938 T1577 T1576 nummod 31,32
R939 T1578 T1576 punct ",",32
R940 T1579 T1576 punct ],32
R941 T1609 T1607 pobj ribbon,of
R942 T1580 T1555 punct .,terminate
R943 T1582 T1583 compound Rod,spherules
R944 T1610 T1606 prep in,presence
R945 T1583 T1584 nsubj spherules,establish
R946 T1611 T1612 det the,cytoplasm
R947 T1585 T1586 det an,synapse
R948 T1586 T1584 dobj synapse,establish
R949 T1587 T1586 amod invaginating,synapse
R950 T1588 T1586 prep with,synapse
R951 T1612 T1610 pobj cytoplasm,in
R952 T1613 T1612 amod presynaptic,cytoplasm
R953 T1614 T1602 punct .,characterized
R954 T1616 T1617 compound Cone,pedicles
R955 T1695 T1688 dobj examination,extended
R956 T1696 T1695 prep of,examination
R957 T1617 T1618 nsubj pedicles,make
R958 T1697 T1698 amod retinal,pathology
R959 T1698 T1696 pobj pathology,of
R960 T1619 T1620 amod invaginating,synapses
R961 T1699 T1688 prep to,extended
R962 T1700 T1701 det the,level
R963 T1701 T1699 pobj level,to
R964 T1702 T1701 amod ultrastructural,level
R965 T1620 T1618 dobj synapses,make
R966 T1703 T1688 punct .,extended
R967 T1621 T1618 prep with,make
R968 T1705 T1706 amod Certain,features
R969 T1706 T1707 nsubjpass features,detected
R970 T1622 T1623 det the,dendrites
R971 T1708 T1706 prep of,features
R972 T1709 T1710 amod neuronal,differentiation
R973 T1623 T1621 pobj dendrites,with
R974 T1710 T1708 pobj differentiation,of
R975 T1711 T1706 punct ", ",features
R976 T1624 T1623 prep of,dendrites
R977 T1712 T1713 amod such,as
R978 T1713 T1706 prep as,features
R979 T1714 T1715 compound synapse,formation
R980 T1625 T1626 nmod on,cells
R981 T1715 T1713 pobj formation,as
R982 T1716 T1707 punct ", ",detected
R983 T1717 T1707 aux can,detected
R984 T1626 T1624 pobj cells,of
R985 T1718 T1707 auxpass be,detected
R986 T1719 T1707 advmod definitively,detected
R987 T1720 T1707 prep at,detected
R988 T1721 T1722 det this,level
R989 T1722 T1720 pobj level,at
R990 T1723 T1722 prep of,level
R991 T1627 T1625 punct -,on
R992 T1724 T1723 pobj analysis,of
R993 T1725 T1707 punct .,detected
R994 T1628 T1625 pobj cone,on
R995 T1727 T1728 prep With,analyzed
R996 T1729 T1730 det the,hope
R997 T1629 T1626 amod bipolar,cells
R998 T1730 T1727 pobj hope,With
R999 T1731 T1730 prep of,hope
R1000 T1630 T1618 cc and,make
R1001 T1732 T1731 pcomp understanding,of
R1002 T1733 T1734 det the,neuropathology
R1003 T1734 T1732 dobj neuropathology,understanding
R1004 T1735 T1734 prep of,neuropathology
R1005 T1631 T1632 amod horizontal,cells
R1006 T1736 T1735 pobj LCA,of
R1007 T1737 T1732 prep in,understanding
R1008 T1738 T1739 amod greater,detail
R1009 T1632 T1618 conj cells,make
R1010 T1739 T1737 pobj detail,in
R1011 T1740 T1728 punct ", ",analyzed
R1012 T1741 T1728 nsubj we,analyzed
R1013 T1633 T1632 cc and,cells
R1014 T1742 T1728 aux have,analyzed
R1015 T1743 T1744 det the,differentiation
R1016 T1634 T1635 amod basal,junctions
R1017 T1744 T1728 dobj differentiation,analyzed
R1018 T1745 T1744 prep of,differentiation
R1019 T1746 T1747 det the,retina
R1020 T1635 T1632 conj junctions,cells
R1021 T1747 T1745 pobj retina,of
R1022 T1748 T1747 amod outer,retina
R1023 T1749 T1744 prep in,differentiation
R1024 T1636 T1632 prep with,cells
R1025 T1750 T1751 nmod Crx,mice
R1026 T1751 T1749 pobj mice,in
R1027 T1752 T1750 punct -,Crx
R1028 T1637 T1638 det the,dendrites
R1029 T1753 T1750 punct /,Crx
R1030 T1754 T1750 punct -,Crx
R1031 T1755 T1728 prep at,analyzed
R1032 T1638 T1636 pobj dendrites,with
R1033 T1756 T1757 det the,level
R1034 T1757 T1755 pobj level,at
R1035 T1639 T1638 prep of,dendrites
R1036 T1758 T1757 amod ultrastructural,level
R1037 T1759 T1728 punct .,analyzed
R1038 T1761 T1762 det These,retinas
R1039 T1762 T1763 nsubj retinas,exhibit
R1040 T1764 T1765 amod several,defects
R1041 T1640 T1641 nmod off,cells
R1042 T1765 T1763 dobj defects,exhibit
R1043 T1766 T1765 amod prominent,defects
R1044 T1767 T1763 punct .,exhibit
R1045 T1641 T1639 pobj cells,of
R1046 T1769 T1770 nmod Crx,photoreceptors
R1047 T1770 T1774 nsubj photoreceptors,demonstrate
R1048 T1642 T1640 punct -,off
R1049 T1771 T1769 punct -,Crx
R1050 T1772 T1769 punct /,Crx
R1051 T1643 T1640 pobj cone,off
R1052 T1773 T1769 punct -,Crx
R1053 T1775 T1776 det a,block
R1054 T1644 T1641 amod bipolar,cells
R1055 T1776 T1774 dobj block,demonstrate
R1056 T1777 T1776 amod complete,block
R1057 T1778 T1776 prep in,block
R1058 T1645 T1618 punct .,make
R1059 T1779 T1780 amod outer,segment
R1060 T1647 T1648 det The,factors
R1061 T1780 T1781 compound segment,formation
R1062 T1648 T1649 nsubj factors,are
R1063 T1781 T1778 pobj formation,in
R1064 T1782 T1774 prep at,demonstrate
R1065 T1650 T1648 acl regulating,factors
R1066 T1783 T1784 det the,stage
R1067 T1784 T1782 pobj stage,at
R1068 T1785 T1784 compound elongation,stage
R1069 T1786 T1774 punct .,demonstrate
R1070 T1651 T1652 det the,formation
R1071 T1788 T1789 advmod Further,exhibit
R1072 T1652 T1650 dobj formation,regulating
R1073 T1790 T1789 punct ", ",exhibit
R1074 T1653 T1652 prep of,formation
R1075 T1791 T1792 det these,cells
R1076 T1792 T1789 nsubj cells,exhibit
R1077 T1793 T1794 amod abnormal,morphology
R1078 T1794 T1789 dobj morphology,exhibit
R1079 T1654 T1655 det the,synapses
R1080 T1795 T1794 amod synaptic,morphology
R1081 T1655 T1653 pobj synapses,of
R1082 T1796 T1789 punct ", ",exhibit
R1083 T1797 T1798 advmod thereby,broadening
R1084 T1798 T1789 advcl broadening,exhibit
R1085 T1656 T1655 compound photoreceptor,synapses
R1086 T1799 T1800 det the,function
R1087 T1800 T1798 dobj function,broadening
R1088 T1657 T1658 advmod completely,unknown
R1089 T1658 T1649 acomp unknown,are
R1090 T1801 T1800 prep of,function
R1091 T1802 T1801 pobj Crx,of
R1092 T1803 T1798 prep to,broadening
R1093 T1804 T1805 compound photoreceptor,synaptogenesis
R1094 T1805 T1803 pobj synaptogenesis,to
R1095 T1659 T1649 punct .,are
R1096 T1806 T1789 punct .,exhibit
R1097 T1808 T1809 nsubj This,represents
R1098 T1661 T1662 advmod At,one
R1099 T1810 T1811 det the,report
R1100 T1811 T1809 dobj report,represents
R1101 T1662 T1664 nummod one,protein
R1102 T1812 T1811 amod first,report
R1103 T1813 T1814 advmod strongly,implicating
R1104 T1814 T1811 acl implicating,report
R1105 T1663 T1662 advmod least,one
R1106 T1664 T1667 nsubj protein,contains
R1107 T1815 T1816 det the,process
R1108 T1816 T1814 dobj process,implicating
R1109 T1665 T1664 nmod photoreceptor,protein
R1110 T1817 T1816 prep of,process
R1111 T1818 T1819 compound synapse,formation
R1112 T1819 T1817 pobj formation,of
R1113 T1666 T1664 amod synaptic,protein
R1114 T1820 T1814 prep in,implicating
R1115 T1821 T1820 pobj LCA,in
R1116 T1822 T1809 punct .,represents
R1117 T1668 T1664 punct ", ",protein
R1118 T1669 T1664 appos HRG4,protein
R1119 T1670 T1667 punct ", ",contains
R1120 T1671 T1672 det a,sequence
R1121 T1672 T1667 dobj sequence,contains
R1122 T1673 T1672 amod potential,sequence
R1123 T1674 T1672 compound Crx,sequence
R1124 T1675 T1672 compound target,sequence
R1125 T1676 T1667 prep in,contains
R1126 T1677 T1678 poss its,sequence
R1127 T1678 T1676 pobj sequence,in
R1128 T1679 T1678 amod transcriptional,sequence
R1129 T1680 T1678 amod regulatory,sequence
R1130 T1681 T1682 punct [,33
R1131 T1682 T1667 parataxis 33,contains
R1132 T1683 T1682 punct ],33
R1133 T1684 T1667 punct .,contains
R1134 T1686 T1687 amod Few,studies
R1135 T1687 T1688 nsubj studies,extended
R1136 T1689 T1687 prep of,studies
R1137 T1690 T1691 compound LCA,models
R1138 T1691 T1689 pobj models,of
R1139 T1692 T1691 compound animal,models
R1140 T1693 T1688 aux have,extended
R1141 T1694 T1695 poss their,examination
R925 T1606 T1604 pobj presence,by