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PMC:548520 / 107-1243 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T76 59-70 NCBITaxon:1 denotes individuals
T77 101-106 GO:0007567 denotes birth
T78 143-157 _FRAGMENT denotes development of
T79 169-175 GO:0060041 denotes retina
T80 162-175 UBERON:0003902 denotes neural retina
T81 177-186 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T82 190-195 SO_EXT:0000704 denotes genes
T83 212-223 _FRAGMENT denotes development
T84 240-262 GO:0042461 denotes of photoreceptor cells
T85 243-262 CL:0000210 denotes photoreceptor cells
T86 257-262 CL_GO_EXT:cell denotes cells
T87 338-347 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T88 355-368 CL:0000210 denotes photoreceptor
T89 369-382 GO_EXT:transcription denotes transcription
T90 369-389 GO_EXT:transcription_factor denotes transcription factor
T91 391-394 PR_EXT:000005904 denotes Crx
T92 407-410 PR_EXT:000005904 denotes Crx
T93 411-417 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T94 428-432 NCBITaxon:10088 denotes mice
T95 506-509 PR_EXT:000005904 denotes Crx
T96 583-589 UBERON:0000966 denotes retina
T97 593-596 PR_EXT:000005904 denotes Crx
T98 597-603 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T99 604-608 NCBITaxon:10088 denotes mice
T100 624-637 GO:0001750 denotes Outer segment
T101 638-651 GO:0009653 denotes morphogenesis
T102 743-760 GO:0007602 denotes phototransduction
T103 781-784 PR_EXT:000005904 denotes Crx
T104 784-785 SO_EXT:sequence_nullness_or_absence denotes -
T105 786-787 SO_EXT:sequence_nullness_or_absence denotes -
T106 788-802 CL:0000210 denotes photoreceptors
T107 834-842 GO:0045202 denotes synaptic
T108 843-850 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T109 858-879 UBERON:0001790 denotes outer plexiform layer
T110 924-938 GO:0007416 denotes synaptogenesis
T111 952-958 NCBITaxon:33208 denotes animal
T112 1017-1021 SO_EXT:0000704 denotes gene
T113 1051-1064 CL:0000210 denotes photoreceptor
T114 1051-1076 GO:0042461 denotes photoreceptor development
R3 T79 T78 _lexicallyChainedTo retina,development of
R4 T84 T83 _lexicallyChainedTo of photoreceptor cells,development

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T41 59-70 NCBITaxon:1 denotes individuals
T42 101-106 GO:0007567 denotes birth
T43 143-157 _FRAGMENT denotes development of
T44 169-175 GO:0060041 denotes retina
T45 162-175 UBERON:0003902 denotes neural retina
T46 190-195 SO:0000704 denotes genes
T47 212-223 _FRAGMENT denotes development
T48 240-262 GO:0042461 denotes of photoreceptor cells
T49 243-262 CL:0000210 denotes photoreceptor cells
T50 355-368 CL:0000210 denotes photoreceptor
T51 391-394 PR:000005904 denotes Crx
T52 407-410 PR:000005904 denotes Crx
T53 428-432 NCBITaxon:10088 denotes mice
T54 506-509 PR:000005904 denotes Crx
T55 583-589 UBERON:0000966 denotes retina
T56 593-596 PR:000005904 denotes Crx
T57 604-608 NCBITaxon:10088 denotes mice
T58 624-637 GO:0001750 denotes Outer segment
T59 638-651 GO:0009653 denotes morphogenesis
T60 743-760 GO:0007602 denotes phototransduction
T61 781-784 PR:000005904 denotes Crx
T62 788-802 CL:0000210 denotes photoreceptors
T63 834-842 GO:0045202 denotes synaptic
T64 858-879 UBERON:0001790 denotes outer plexiform layer
T65 924-938 GO:0007416 denotes synaptogenesis
T66 952-958 NCBITaxon:33208 denotes animal
T67 1017-1021 SO:0000704 denotes gene
T68 1051-1064 CL:0000210 denotes photoreceptor
T69 1051-1076 GO:0042461 denotes photoreceptor development
R1 T44 T43 _lexicallyChainedTo retina,development of
R2 T48 T47 _lexicallyChainedTo of photoreceptor cells,development

craft-sa-dev

Id Subject Object Predicate Lexical cue
T132 0-10 sentence denotes Background
T133 0-10 NN denotes Background
T134 10-107 sentence denotes In Leber's congenital amaurosis (LCA), affected individuals are blind, or nearly so, from birth.
T135 11-13 IN denotes In
T136 71-74 VBP denotes are
T137 14-19 NNP denotes Leber
T138 33-42 NN denotes amaurosis
T139 19-21 POS denotes 's
T140 22-32 JJ denotes congenital
T141 43-44 -LRB- denotes (
T142 44-47 NN denotes LCA
T143 47-48 -RRB- denotes )
T144 48-50 , denotes ,
T145 50-58 VBN denotes affected
T146 59-70 NNS denotes individuals
T147 75-80 JJ denotes blind
T148 80-82 , denotes ,
T149 82-84 CC denotes or
T150 85-91 RB denotes nearly
T151 92-94 RB denotes so
T152 94-96 , denotes ,
T153 96-100 IN denotes from
T154 101-106 NN denotes birth
T155 106-107 . denotes .
T156 107-176 sentence denotes This early onset suggests abnormal development of the neural retina.
T157 108-112 DT denotes This
T158 119-124 NN denotes onset
T159 113-118 JJ denotes early
T160 125-133 VBZ denotes suggests
T161 134-142 JJ denotes abnormal
T162 143-154 NN denotes development
T163 155-157 IN denotes of
T164 158-161 DT denotes the
T165 169-175 NN denotes retina
T166 162-168 JJ denotes neural
T167 175-176 . denotes .
T168 176-314 sentence denotes Mutations in genes that affect the development and/or function of photoreceptor cells have been found to be responsible in some families.
T169 177-186 NNS denotes Mutations
T170 273-278 VBN denotes found
T171 187-189 IN denotes in
T172 190-195 NNS denotes genes
T173 196-200 WDT denotes that
T174 201-207 VBP denotes affect
T175 208-211 DT denotes the
T176 212-223 NN denotes development
T177 224-227 CC denotes and
T178 227-228 HYPH denotes /
T179 228-230 CC denotes or
T180 231-239 NN denotes function
T181 240-242 IN denotes of
T182 243-256 NN denotes photoreceptor
T183 257-262 NNS denotes cells
T184 263-267 VBP denotes have
T185 268-272 VBN denotes been
T186 279-281 TO denotes to
T187 282-284 VB denotes be
T188 285-296 JJ denotes responsible
T189 297-299 IN denotes in
T190 300-304 DT denotes some
T191 305-313 NNS denotes families
T192 313-314 . denotes .
T193 314-395 sentence denotes These examples include mutations in the photoreceptor transcription factor, Crx.
T194 315-320 DT denotes These
T195 321-329 NNS denotes examples
T196 330-337 VBP denotes include
T197 338-347 NNS denotes mutations
T198 348-350 IN denotes in
T199 351-354 DT denotes the
T200 383-389 NN denotes factor
T201 355-368 NN denotes photoreceptor
T202 369-382 NN denotes transcription
T203 389-391 , denotes ,
T204 391-394 NN denotes Crx
T205 394-395 . denotes .
T206 395-404 sentence denotes Results
T207 397-404 NNS denotes Results
T208 404-521 sentence denotes A Crx mutant strain of mice was created to serve as a model for LCA and to provide more insight into Crx's function.
T209 405-406 DT denotes A
T210 418-424 NN denotes strain
T211 407-410 NN denotes Crx
T212 411-417 JJ denotes mutant
T213 437-444 VBN denotes created
T214 425-427 IN denotes of
T215 428-432 NNS denotes mice
T216 433-436 VBD denotes was
T217 445-447 TO denotes to
T218 448-453 VB denotes serve
T219 454-456 IN denotes as
T220 457-458 DT denotes a
T221 459-464 NN denotes model
T222 465-468 IN denotes for
T223 469-472 NN denotes LCA
T224 473-476 CC denotes and
T225 477-479 TO denotes to
T226 480-487 VB denotes provide
T227 488-492 JJR denotes more
T228 493-500 NN denotes insight
T229 501-505 IN denotes into
T230 506-509 NN denotes Crx
T231 512-520 NN denotes function
T232 509-511 POS denotes 's
T233 520-521 . denotes .
T234 521-623 sentence denotes In this study, an ultrastructural analysis of the developing retina in Crx mutant mice was performed.
T235 522-524 IN denotes In
T236 613-622 VBN denotes performed
T237 525-529 DT denotes this
T238 530-535 NN denotes study
T239 535-537 , denotes ,
T240 537-539 DT denotes an
T241 556-564 NN denotes analysis
T242 540-555 JJ denotes ultrastructural
T243 565-567 IN denotes of
T244 568-571 DT denotes the
T245 583-589 NN denotes retina
T246 572-582 VBG denotes developing
T247 590-592 IN denotes in
T248 593-596 NN denotes Crx
T249 604-608 NNS denotes mice
T250 597-603 NN denotes mutant
T251 609-612 VBD denotes was
T252 622-623 . denotes .
T253 623-771 sentence denotes Outer segment morphogenesis was found to be blocked at the elongation stage, leading to a failure in production of the phototransduction apparatus.
T254 624-629 JJ denotes Outer
T255 638-651 NN denotes morphogenesis
T256 630-637 NN denotes segment
T257 656-661 VBN denotes found
T258 652-655 VBD denotes was
T259 662-664 TO denotes to
T260 668-675 VBN denotes blocked
T261 665-667 VB denotes be
T262 676-678 IN denotes at
T263 679-682 DT denotes the
T264 694-699 NN denotes stage
T265 683-693 NN denotes elongation
T266 699-701 , denotes ,
T267 701-708 VBG denotes leading
T268 709-711 IN denotes to
T269 712-713 DT denotes a
T270 714-721 NN denotes failure
T271 722-724 IN denotes in
T272 725-735 NN denotes production
T273 736-738 IN denotes of
T274 739-742 DT denotes the
T275 761-770 NN denotes apparatus
T276 743-760 NN denotes phototransduction
T277 770-771 . denotes .
T278 771-880 sentence denotes Further, Crx-/- photoreceptors demonstrated severely abnormal synaptic endings in the outer plexiform layer.
T279 772-779 RB denotes Further
T280 803-815 VBD denotes demonstrated
T281 779-781 , denotes ,
T282 781-784 NN denotes Crx
T283 788-802 NNS denotes photoreceptors
T284 784-785 SYM denotes -
T285 785-786 HYPH denotes /
T286 786-787 SYM denotes -
T287 816-824 RB denotes severely
T288 825-833 JJ denotes abnormal
T289 843-850 NNS denotes endings
T290 834-842 JJ denotes synaptic
T291 851-853 IN denotes in
T292 854-857 DT denotes the
T293 874-879 NN denotes layer
T294 858-863 JJ denotes outer
T295 864-873 NN denotes plexiform
T296 879-880 . denotes .
T297 880-893 sentence denotes Conclusions
T298 882-893 NNS denotes Conclusions
T299 893-973 sentence denotes This is the first report of a synaptogenesis defect in an animal model for LCA.
T300 894-898 DT denotes This
T301 899-901 VBZ denotes is
T302 902-905 DT denotes the
T303 912-918 NN denotes report
T304 906-911 JJ denotes first
T305 919-921 IN denotes of
T306 922-923 DT denotes a
T307 939-945 NN denotes defect
T308 924-938 NN denotes synaptogenesis
T309 946-948 IN denotes in
T310 949-951 DT denotes an
T311 959-964 NN denotes model
T312 952-958 NN denotes animal
T313 965-968 IN denotes for
T314 969-972 NN denotes LCA
T315 972-973 . denotes .
T316 973-1136 sentence denotes These data confirm the essential role this gene plays in multiple aspects of photoreceptor development and extend our understanding of the basic pathology of LCA.
T317 974-979 DT denotes These
T318 980-984 NNS denotes data
T319 985-992 VBP denotes confirm
T320 993-996 DT denotes the
T321 1007-1011 NN denotes role
T322 997-1006 JJ denotes essential
T323 1012-1016 DT denotes this
T324 1017-1021 NN denotes gene
T325 1022-1027 VBZ denotes plays
T326 1028-1030 IN denotes in
T327 1031-1039 JJ denotes multiple
T328 1040-1047 NNS denotes aspects
T329 1048-1050 IN denotes of
T330 1051-1064 NN denotes photoreceptor
T331 1065-1076 NN denotes development
T332 1077-1080 CC denotes and
T333 1081-1087 VBP denotes extend
T334 1088-1091 PRP$ denotes our
T335 1092-1105 NN denotes understanding
T336 1106-1108 IN denotes of
T337 1109-1112 DT denotes the
T338 1119-1128 NN denotes pathology
T339 1113-1118 JJ denotes basic
T340 1129-1131 IN denotes of
T341 1132-1135 NN denotes LCA
T342 1135-1136 . denotes .
R86 T214 T210 prep of,strain
R87 T215 T214 pobj mice,of
R18 T135 T136 prep In,are
R19 T137 T138 poss Leber,amaurosis
R20 T138 T135 pobj amaurosis,In
R21 T139 T137 case 's,Leber
R22 T140 T138 amod congenital,amaurosis
R23 T141 T138 punct (,amaurosis
R24 T142 T138 appos LCA,amaurosis
R25 T143 T136 punct ),are
R26 T144 T136 punct ", ",are
R27 T145 T146 amod affected,individuals
R28 T146 T136 nsubj individuals,are
R29 T147 T136 acomp blind,are
R30 T148 T147 punct ", ",blind
R31 T149 T147 cc or,blind
R32 T150 T151 advmod nearly,so
R33 T151 T147 conj so,blind
R34 T152 T136 punct ", ",are
R35 T153 T136 prep from,are
R36 T154 T153 pobj birth,from
R37 T155 T136 punct .,are
R38 T157 T158 det This,onset
R39 T158 T160 nsubj onset,suggests
R40 T159 T158 amod early,onset
R41 T161 T162 amod abnormal,development
R42 T162 T160 dobj development,suggests
R43 T163 T162 prep of,development
R44 T164 T165 det the,retina
R45 T165 T163 pobj retina,of
R46 T166 T165 amod neural,retina
R47 T167 T160 punct .,suggests
R48 T169 T170 nsubjpass Mutations,found
R49 T171 T169 prep in,Mutations
R50 T172 T171 pobj genes,in
R51 T173 T174 dep that,affect
R52 T174 T172 relcl affect,genes
R53 T175 T176 det the,development
R54 T176 T174 dobj development,affect
R55 T177 T176 cc and,development
R56 T178 T177 punct /,and
R57 T179 T177 cc or,and
R58 T180 T176 conj function,development
R59 T181 T176 prep of,development
R60 T182 T183 compound photoreceptor,cells
R61 T183 T181 pobj cells,of
R62 T184 T170 aux have,found
R63 T185 T170 auxpass been,found
R64 T186 T187 aux to,be
R65 T187 T170 xcomp be,found
R66 T188 T187 acomp responsible,be
R67 T189 T170 prep in,found
R68 T190 T191 det some,families
R69 T191 T189 pobj families,in
R70 T192 T170 punct .,found
R71 T194 T195 det These,examples
R72 T195 T196 nsubj examples,include
R73 T197 T196 dobj mutations,include
R74 T198 T197 prep in,mutations
R75 T199 T200 det the,factor
R76 T200 T198 pobj factor,in
R77 T201 T202 compound photoreceptor,transcription
R78 T202 T200 compound transcription,factor
R79 T203 T200 punct ", ",factor
R80 T204 T200 appos Crx,factor
R81 T205 T196 punct .,include
R82 T209 T210 det A,strain
R83 T210 T213 nsubjpass strain,created
R84 T211 T210 nmod Crx,strain
R85 T212 T210 amod mutant,strain
R88 T216 T213 auxpass was,created
R89 T217 T218 aux to,serve
R90 T218 T213 advcl serve,created
R91 T219 T218 prep as,serve
R92 T220 T221 det a,model
R93 T221 T219 pobj model,as
R94 T222 T221 prep for,model
R95 T223 T222 pobj LCA,for
R96 T224 T218 cc and,serve
R97 T225 T226 aux to,provide
R98 T226 T218 conj provide,serve
R99 T227 T228 amod more,insight
R100 T228 T226 dobj insight,provide
R101 T229 T228 prep into,insight
R102 T230 T231 poss Crx,function
R103 T231 T229 pobj function,into
R104 T232 T230 case 's,Crx
R105 T233 T213 punct .,created
R106 T235 T236 prep In,performed
R107 T237 T238 det this,study
R108 T238 T235 pobj study,In
R109 T239 T236 punct ", ",performed
R110 T240 T241 det an,analysis
R111 T241 T236 nsubjpass analysis,performed
R112 T242 T241 amod ultrastructural,analysis
R113 T243 T241 prep of,analysis
R114 T244 T245 det the,retina
R115 T245 T243 pobj retina,of
R116 T246 T245 amod developing,retina
R117 T247 T245 prep in,retina
R118 T248 T249 compound Crx,mice
R119 T249 T247 pobj mice,in
R120 T250 T249 compound mutant,mice
R121 T251 T236 auxpass was,performed
R122 T252 T236 punct .,performed
R123 T254 T255 amod Outer,morphogenesis
R124 T255 T257 nsubjpass morphogenesis,found
R125 T256 T255 compound segment,morphogenesis
R126 T258 T257 auxpass was,found
R127 T259 T260 aux to,blocked
R128 T260 T257 xcomp blocked,found
R129 T261 T260 auxpass be,blocked
R130 T262 T260 prep at,blocked
R131 T263 T264 det the,stage
R132 T264 T262 pobj stage,at
R133 T265 T264 compound elongation,stage
R134 T266 T260 punct ", ",blocked
R135 T267 T260 advcl leading,blocked
R136 T268 T267 prep to,leading
R137 T269 T270 det a,failure
R138 T270 T268 pobj failure,to
R139 T271 T270 prep in,failure
R140 T272 T271 pobj production,in
R141 T273 T272 prep of,production
R142 T274 T275 det the,apparatus
R143 T275 T273 pobj apparatus,of
R144 T276 T275 compound phototransduction,apparatus
R145 T277 T257 punct .,found
R146 T279 T280 advmod Further,demonstrated
R147 T281 T280 punct ", ",demonstrated
R148 T282 T283 nmod Crx,photoreceptors
R150 T284 T282 punct -,Crx
R151 T285 T282 punct /,Crx
R152 T286 T282 punct -,Crx
R153 T287 T288 advmod severely,abnormal
R154 T288 T289 amod abnormal,endings
R155 T289 T280 dobj endings,demonstrated
R156 T290 T289 amod synaptic,endings
R157 T291 T289 prep in,endings
R158 T292 T293 det the,layer
R159 T293 T291 pobj layer,in
R160 T294 T293 amod outer,layer
R161 T295 T293 compound plexiform,layer
R162 T296 T280 punct .,demonstrated
R163 T300 T301 nsubj This,is
R164 T302 T303 det the,report
R165 T303 T301 attr report,is
R166 T304 T303 amod first,report
R167 T305 T303 prep of,report
R168 T306 T307 det a,defect
R169 T307 T305 pobj defect,of
R170 T308 T307 compound synaptogenesis,defect
R171 T309 T307 prep in,defect
R172 T310 T311 det an,model
R173 T311 T309 pobj model,in
R174 T312 T311 compound animal,model
R175 T313 T311 prep for,model
R176 T314 T313 pobj LCA,for
R177 T315 T301 punct .,is
R178 T317 T318 det These,data
R179 T318 T319 nsubj data,confirm
R180 T320 T321 det the,role
R181 T321 T319 dobj role,confirm
R182 T322 T321 amod essential,role
R183 T323 T324 det this,gene
R184 T324 T325 nsubj gene,plays
R185 T325 T321 advcl plays,role
R186 T326 T325 prep in,plays
R187 T327 T328 amod multiple,aspects
R188 T328 T326 pobj aspects,in
R189 T329 T328 prep of,aspects
R190 T330 T331 compound photoreceptor,development
R191 T331 T329 pobj development,of
R192 T332 T319 cc and,confirm
R193 T333 T319 conj extend,confirm
R194 T334 T335 poss our,understanding
R195 T335 T333 dobj understanding,extend
R196 T336 T335 prep of,understanding
R197 T337 T338 det the,pathology
R198 T338 T336 pobj pathology,of
R199 T339 T338 amod basic,pathology
R200 T340 T338 prep of,pathology
R201 T341 T340 pobj LCA,of
R202 T342 T319 punct .,confirm
R149 T283 T280 nsubj photoreceptors,demonstrated