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2_test

Id Subject Object Predicate Lexical cue
15676071-9540407-12933239 1590-1591 9540407 denotes 1
15676071-14562518-12933239 1590-1591 14562518 denotes 1
15676071-12015282-12933239 1590-1591 12015282 denotes 1
15676071-14562518-12933240 1957-1958 14562518 denotes 2
15676071-14527271-12933241 1959-1960 14527271 denotes 4
15676071-9390516-12933242 2121-2122 9390516 denotes 5
15676071-9390563-12933242 2121-2122 9390563 denotes 5
15676071-9390562-12933242 2121-2122 9390562 denotes 5
15676071-14625556-12933243 2274-2275 14625556 denotes 8
15676071-10887186-12933244 2446-2447 10887186 denotes 9
15676071-10744971-12933245 2548-2550 10744971 denotes 10
15676071-8576239-12933246 2574-2576 8576239 denotes 11
15676071-10336455-12933247 2592-2594 10336455 denotes 12
15676071-9390563-12933248 2719-2720 9390563 denotes 6
15676071-9427255-12933249 2721-2723 9427255 denotes 13
15676071-9792858-12933250 2724-2726 9792858 denotes 14
15676071-9792858-12933251 2751-2753 9792858 denotes 14
15676071-9792858-12933252 2765-2767 9792858 denotes 14
15676071-9537410-12933252 2765-2767 9537410 denotes 14
15676071-9931337-12933252 2765-2767 9931337 denotes 14
15676071-9390516-12933253 2903-2904 9390516 denotes 5
15676071-9390562-12933254 2905-2906 9390562 denotes 7
15676071-15231395-12933255 2972-2974 15231395 denotes 17
15676071-9792858-12933256 3161-3163 9792858 denotes 14
15676071-9537410-12933257 3164-3166 9537410 denotes 15
15676071-8944027-12933258 3188-3190 8944027 denotes 18
15676071-9326927-12933259 3200-3202 9326927 denotes 19
15676071-10615133-12933260 3213-3215 10615133 denotes 20
15676071-12567265-12933261 3225-3227 12567265 denotes 21
15676071-11283794-12933262 3244-3246 11283794 denotes 22
15676071-10631161-12933263 3357-3359 10631161 denotes 23
15676071-9792858-12933264 3496-3498 9792858 denotes 14
15676071-9537410-12933265 3499-3501 9537410 denotes 15
15676071-9931337-12933266 3627-3629 9931337 denotes 16
15676071-15231395-12933267 3835-3837 15231395 denotes 17
15676071-12124981-12933268 4041-4043 12124981 denotes 24
15676071-9448321-12933269 4183-4185 9448321 denotes 25
15676071-15180294-12933269 4183-4185 15180294 denotes 25
15676071-12692160-12933269 4183-4185 12692160 denotes 25
15676071-11528395-12933269 4183-4185 11528395 denotes 25
15676071-9020854-12933270 4745-4747 9020854 denotes 29
15676071-6715580-12933271 4789-4791 6715580 denotes 30
15676071-13694328-12933272 4982-4984 13694328 denotes 31
15676071-10329014-12933273 5592-5594 10329014 denotes 33
15676071-10581037-12933274 6649-6651 10581037 denotes 34
15676071-10744971-12933275 14305-14307 10744971 denotes 10
15676071-10581037-12933276 14308-14310 10581037 denotes 34
15676071-11733058-12933277 14311-14313 11733058 denotes 35
15676071-9020854-12933278 14448-14450 9020854 denotes 29
15676071-6715580-12933279 14451-14453 6715580 denotes 30
15676071-9390562-12933280 15133-15134 9390562 denotes 7
15676071-7207866-12933281 19710-19712 7207866 denotes 36
15676071-9020854-12933282 19731-19733 9020854 denotes 29
15676071-6715580-12933283 20277-20279 6715580 denotes 30
15676071-2144827-12933284 20497-20499 2144827 denotes 37
15676071-6771304-12933285 20738-20740 6771304 denotes 38
15676071-8943002-12933286 20962-20964 8943002 denotes 39
15676071-9020854-12933287 20965-20967 9020854 denotes 29
15676071-10802659-12933288 21039-21041 10802659 denotes 40
15676071-10581037-12933289 21270-21272 10581037 denotes 34
15676071-10744971-12933290 21288-21290 10744971 denotes 10
15676071-11733058-12933291 21340-21342 11733058 denotes 35
15676071-1418997-12933292 21676-21678 1418997 denotes 41
15676071-8575336-12933293 22059-22061 8575336 denotes 42
15676071-9020854-12933294 22115-22117 9020854 denotes 29
15676071-9245510-12933295 22162-22164 9245510 denotes 43
15676071-9570804-12933296 22956-22958 9570804 denotes 44
15676071-8575625-12933297 23460-23462 8575625 denotes 45
15676071-11733058-12933298 23723-23725 11733058 denotes 35
15676071-15324661-12933299 24448-24450 15324661 denotes 46
15676071-11850625-12933300 24547-24549 11850625 denotes 47
15676071-12915475-12933301 24690-24692 12915475 denotes 48
15676071-6715580-12933302 25214-25216 6715580 denotes 30
15676071-15161873-12933303 25388-25390 15161873 denotes 49
15676071-6055897-12933304 26039-26041 6055897 denotes 50
15676071-563768-12933305 26042-26044 563768 denotes 51
15676071-11733058-12933306 26819-26821 11733058 denotes 35
15676071-10329014-12933307 27510-27512 10329014 denotes 33
15676071-10531444-12933308 28212-28214 10531444 denotes 52
15676071-11748842-12933309 29321-29323 11748842 denotes 53
15676071-8512479-12933310 29507-29509 8512479 denotes 54
15676071-8541873-12933311 29614-29616 8541873 denotes 55
15676071-11733058-12933312 29804-29806 11733058 denotes 35
15676071-15231395-12933313 30295-30297 15231395 denotes 17
15676071-4051853-12933314 30298-30300 4051853 denotes 56
15676071-14730587-12933315 30784-30786 14730587 denotes 57
15676071-12124981-12933316 30945-30947 12124981 denotes 24
15676071-10581037-12933317 31614-31616 10581037 denotes 34
15676071-9020854-12933318 31639-31641 9020854 denotes 29

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T70 0-14 GO:0007416 denotes Synaptogenesis
T71 19-32 GO:0001750 denotes outer segment
T72 64-77 UBERON:0003902 denotes neural retina
T73 81-84 PR_EXT:000005904 denotes Crx
T74 85-91 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T75 92-96 NCBITaxon:10088 denotes mice
T76 166-177 NCBITaxon:1 denotes individuals
T77 208-213 GO:0007567 denotes birth
T78 250-264 _FRAGMENT denotes development of
T79 276-282 GO:0060041 denotes retina
T80 269-282 UBERON:0003902 denotes neural retina
T81 284-293 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T82 297-302 SO_EXT:0000704 denotes genes
T83 319-330 _FRAGMENT denotes development
T84 347-369 GO:0042461 denotes of photoreceptor cells
T85 350-369 CL:0000210 denotes photoreceptor cells
T86 364-369 CL_GO_EXT:cell denotes cells
T87 445-454 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T88 462-475 CL:0000210 denotes photoreceptor
T89 476-489 GO_EXT:transcription denotes transcription
T90 476-496 GO_EXT:transcription_factor denotes transcription factor
T91 498-501 PR_EXT:000005904 denotes Crx
T92 514-517 PR_EXT:000005904 denotes Crx
T93 518-524 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T94 535-539 NCBITaxon:10088 denotes mice
T95 613-616 PR_EXT:000005904 denotes Crx
T96 690-696 UBERON:0000966 denotes retina
T97 700-703 PR_EXT:000005904 denotes Crx
T98 704-710 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T99 711-715 NCBITaxon:10088 denotes mice
T100 731-744 GO:0001750 denotes Outer segment
T101 745-758 GO:0009653 denotes morphogenesis
T102 850-867 GO:0007602 denotes phototransduction
T103 888-891 PR_EXT:000005904 denotes Crx
T104 891-892 SO_EXT:sequence_nullness_or_absence denotes -
T105 893-894 SO_EXT:sequence_nullness_or_absence denotes -
T106 895-909 CL:0000210 denotes photoreceptors
T107 941-949 GO:0045202 denotes synaptic
T108 950-957 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T109 965-986 UBERON:0001790 denotes outer plexiform layer
T110 1031-1045 GO:0007416 denotes synaptogenesis
T111 1059-1065 NCBITaxon:33208 denotes animal
T112 1124-1128 SO_EXT:0000704 denotes gene
T113 1158-1171 CL:0000210 denotes photoreceptor
T114 1158-1183 GO:0042461 denotes photoreceptor development
T627 1256-1275 CL:0000210 denotes Photoreceptor cells
T628 1270-1275 CL_GO_EXT:cell denotes cells
T629 1299-1305 GO:0007601 denotes vision
T630 1355-1361 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T631 1377-1384 GO_EXT:detection_or_sensing_of_stimulus denotes sensory
T632 1377-1392 CL:0000101 denotes sensory neurons
T633 1421-1430 NCBITaxon:1 denotes organisms
T634 1442-1449 GO_EXT:detection_or_sensing_of_stimulus denotes sensing
T635 1460-1466 NCBITaxon:9606 denotes humans
T636 1468-1475 SO_EXT:0000704 denotes genetic
T637 1492-1495 UBERON:0000970 denotes eye
T638 1558-1572 CL:0000210 denotes photoreceptors
T639 1597-1611 CL:0000210 denotes Photoreceptors
T640 1686-1696 GO_PATO_EXT:physiological_process_or_quality denotes physiology
T641 1700-1717 GO:0007602 denotes phototransduction
T642 1736-1750 _FRAGMENT denotes development of
T643 1762-1776 GO:0042461 denotes photoreceptors
T644 1751-1761 NCBITaxon:7742 denotes vertebrate
T645 1762-1776 CL:0000210 denotes photoreceptors
T646 1865-1874 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T647 1886-1896 GO:0065007 denotes regulating
T648 1897-1910 CL:0000210 denotes photoreceptor
T649 1897-1922 GO:0042461 denotes photoreceptor development
T650 1964-1967 PR_EXT:000005904 denotes Crx
T651 1969-1973 CL:0000573 denotes cone
T652 1969-1986 PR_EXT:000005904 denotes cone-rod homeobox
T653 1974-1977 CL:0000604 denotes rod
T654 1994-1997 PR_EXT:OTX denotes otx
T655 2014-2018 SO_EXT:0000704 denotes gene
T656 2019-2028 GO:0010467 denotes expressed
T657 2046-2060 CL:0000210 denotes photoreceptors
T658 2109-2114 UBERON:0007023 denotes adult
T659 2127-2130 PR_EXT:000005904 denotes Crx
T660 2131-2135 SO_EXT:0000704 denotes gene
T661 2131-2146 GO:0010467 denotes gene expression
T662 2176-2180 PR_EXT:000012086 denotes Otx2
T663 2234-2243 GO:0010467 denotes expressed
T664 2253-2272 CL:0000210 denotes photoreceptor cells
T665 2267-2272 CL_GO_EXT:cell denotes cells
T666 2281-2299 CL:0000604 denotes rod photoreceptors
T667 2301-2304 PR_EXT:000005904 denotes Crx
T668 2337-2340 PR_EXT:000011432 denotes Nrl
T669 2344-2351 CHEBI_SO_EXT:leucine denotes leucine
T670 2359-2366 CHEBI_PR_EXT:protein denotes protein
T671 2398-2408 GO:0010467 denotes expression
T672 2416-2422 UBERON:0000966 denotes retina
T673 2426-2444 CL:0000604 denotes rod photoreceptors
T674 2455-2468 CL:0000210 denotes photoreceptor
T675 2478-2483 SO_EXT:0000704 denotes genes
T676 2498-2501 PR_EXT:000005904 denotes Crx
T677 2502-2509 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T678 2502-2518 SO_EXT:0000409 denotes binding elements
T679 2528-2538 GO:0065007 denotes regulatory
T680 2528-2546 SO_EXT:0005836 denotes regulatory regions
T681 2563-2572 PR_EXT:000001245 denotes rhodopsin
T682 2582-2590 PR_EXT:arrestin denotes arrestin
T683 2597-2606 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T684 2610-2613 PR_EXT:000005904 denotes Crx
T685 2648-2653 NCBITaxon:9606 denotes human
T686 2697-2701 CL:0000573 denotes cone
T687 2702-2705 CL:0000604 denotes rod
T688 2794-2797 PR_EXT:000005904 denotes Crx
T689 2846-2861 _FRAGMENT denotes differentiation
T690 2879-2881 _FRAGMENT denotes of
T691 2896-2901 GO:0030154 denotes cells
T692 2882-2901 CL:0000210 denotes photoreceptor cells
T693 2896-2901 CL_GO_EXT:cell denotes cells
T694 2932-2939 SO_EXT:0000704 denotes genetic
T695 2951-2965 CL:0000210 denotes photoreceptors
T696 3061-3067 GO:0007601 denotes vision
T697 3073-3078 GO:0007567 denotes birth
T698 3080-3089 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T699 3093-3100 UBERON:0000966 denotes retinal
T700 3110-3115 SO_EXT:0000704 denotes genes
T701 3125-3128 PR_EXT:000005904 denotes Crx
T702 3180-3186 PR_EXT:000008353 denotes GUCY2D
T703 3193-3198 PR_EXT:000014179 denotes RPE65
T704 3205-3211 PR_EXT:000003876 denotes AIPL-1
T705 3218-3223 PR_EXT:000005848 denotes CRB-1
T706 3234-3242 PR_EXT:000014182 denotes RPGRIP-1
T707 3295-3318 SO_EXT:0000018 denotes genetically linked loci
T708 3325-3330 SO_EXT:0000704 denotes genes
T709 3362-3365 PR_EXT:000005904 denotes Crx
T710 3366-3375 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T711 3427-3435 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T712 3456-3462 SO_EXT:sequence_coding_function denotes encode
T713 3491-3494 PR_EXT:000005904 denotes Crx
T714 3514-3523 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T715 3565-3571 SO_EXT:0001023 denotes allele
T716 3572-3579 SO_EXT:sequence_coding_function denotes encodes
T717 3582-3589 CHEBI_PR_EXT:protein denotes protein
T718 3605-3608 CHEBI_SO_EXT:DNA denotes DNA
T719 3609-3616 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T720 3811-3816 NCBITaxon:9606 denotes human
T721 3885-3891 UBERON:0010230 denotes globes
T722 3895-3901 UBERON:0007023 denotes adults
T723 3922-3928 UBERON:0000479 denotes tissue
T724 4010-4013 UBERON:0000970 denotes eye
T725 4020-4026 UBERON_EXT:baby_or_infant denotes infant
T726 4046-4052 NCBITaxon:33208 denotes Animal
T727 4221-4232 SO_EXT:0000704 denotes genetically
T728 4268-4273 NCBITaxon:10088 denotes mouse
T729 4350-4363 CL:0000210 denotes photoreceptor
T730 4350-4375 GO:0042461 denotes photoreceptor development
T731 4444-4463 CL:0000210 denotes photoreceptor cells
T732 4458-4463 CL_GO_EXT:cell denotes cells
T733 4507-4515 CL:0000540 denotes neuronal
T734 4516-4531 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T735 4533-4552 CL:0000210 denotes Photoreceptor cells
T736 4547-4552 CL_GO_EXT:cell denotes cells
T737 4584-4588 GO:0045177 denotes apex
T738 4596-4603 CL:0000540 denotes neurons
T739 4611-4621 GO:0016020 denotes membranous
T740 4622-4635 GO:0001750 denotes outer segment
T741 4652-4660 CHEBI_PR_EXT:protein denotes proteins
T742 4677-4702 GO:0007602 denotes phototransduction cascade
T743 4721-4730 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T744 4734-4743 PR_EXT:000001245 denotes rhodopsin
T745 4768-4775 CHEBI_PR_EXT:protein denotes protein
T746 4777-4787 PR_EXT:peripherin denotes peripherin
T747 4825-4839 GO:0001750 denotes outer segments
T748 4865-4879 CL:0000210 denotes photoreceptors
T749 4895-4903 GO:0045202 denotes synaptic
T750 4904-4911 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T751 4939-4951 _FRAGMENT denotes processes of
T752 4975-4980 GO:0042995 denotes cells
T753 4952-4962 _FRAGMENT denotes horizontal
T754 4975-4980 CL:0000745 denotes cells
T755 4967-4980 CL:0000103 denotes bipolar cells
T756 4990-4993 CL:0000604 denotes Rod
T757 4990-5003 GO:0044317 denotes Rod spherules
T758 5030-5037 GO:0045202 denotes synapse
T759 5043-5046 CL:0000604 denotes rod
T760 5055-5064 GO:0030425 denotes dendrites
T761 5069-5083 GO:0043679 denotes axonal endings
T762 5076-5083 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T763 5087-5103 CL:0000745 denotes horizontal cells
T764 5098-5103 CL_GO_EXT:cell denotes cells
T765 5110-5117 GO:0045202 denotes synapse
T766 5170-5181 GO:0098793 denotes presynaptic
T767 5182-5191 GO:0005737 denotes cytoplasm
T768 5193-5197 CL:0000573 denotes Cone
T769 5193-5206 GO:0044316 denotes Cone pedicles
T770 5225-5233 GO:0045202 denotes synapses
T771 5243-5252 GO:0030425 denotes dendrites
T772 5256-5258 _FRAGMENT denotes on
T773 5264-5277 CL:0000749 denotes bipolar cells
T774 5259-5263 CL:0000573 denotes cone
T775 5272-5277 CL_GO_EXT:cell denotes cells
T776 5282-5298 CL:0000745 denotes horizontal cells
T777 5293-5298 CL_GO_EXT:cell denotes cells
T778 5328-5337 GO:0030425 denotes dendrites
T779 5341-5344 _FRAGMENT denotes off
T780 5350-5363 CL:0000750 denotes bipolar cells
T781 5345-5349 CL:0000573 denotes cone
T782 5358-5363 CL_GO_EXT:cell denotes cells
T783 5377-5387 GO:0065007 denotes regulating
T784 5392-5404 _FRAGMENT denotes formation of
T785 5423-5431 GO:0007416 denotes synapses
T786 5409-5422 CL:0000210 denotes photoreceptor
T787 5423-5431 GO:0045202 denotes synapses
T788 5469-5482 CL:0000210 denotes photoreceptor
T789 5483-5491 GO:0045202 denotes synaptic
T790 5492-5499 CHEBI_PR_EXT:protein denotes protein
T791 5501-5505 PR_EXT:000017084 denotes HRG4
T792 5528-5531 PR_EXT:000005904 denotes Crx
T793 5539-5547 SO_EXT:biological_sequence denotes sequence
T794 5555-5570 GO_EXT:transcription denotes transcriptional
T795 5555-5590 SO_EXT:0001679 denotes transcriptional regulatory sequence
T796 5571-5581 GO:0065007 denotes regulatory
T797 5616-5622 NCBITaxon:33208 denotes animal
T798 5665-5672 UBERON:0000966 denotes retinal
T799 5733-5741 CL:0000540 denotes neuronal
T800 5742-5757 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T801 5767-5774 GO:0045202 denotes synapse
T802 5767-5784 GO:0007416 denotes synapse formation
T803 5939-5954 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T804 5968-5974 UBERON:0000966 denotes retina
T805 5978-5981 PR_EXT:000005904 denotes Crx
T806 5981-5982 SO_EXT:sequence_nullness_or_absence denotes -
T807 5983-5984 SO_EXT:sequence_nullness_or_absence denotes -
T808 5985-5989 NCBITaxon:10088 denotes mice
T809 6026-6033 UBERON:0000966 denotes retinas
T810 6069-6072 PR_EXT:000005904 denotes Crx
T811 6072-6073 SO_EXT:sequence_nullness_or_absence denotes -
T812 6074-6075 SO_EXT:sequence_nullness_or_absence denotes -
T813 6076-6090 CL:0000210 denotes photoreceptors
T814 6123-6136 GO:0001750 denotes outer segment
T815 6187-6192 CL_GO_EXT:cell denotes cells
T816 6210-6218 GO:0045202 denotes synaptic
T817 6266-6269 PR_EXT:000005904 denotes Crx
T818 6273-6286 CL:0000210 denotes photoreceptor
T819 6287-6301 GO:0007416 denotes synaptogenesis
T820 6372-6379 GO:0045202 denotes synapse
T821 6372-6389 GO:0007416 denotes synapse formation
T2133 6436-6449 GO:0001750 denotes outer segment
T2134 6436-6455 UBERON:0003926 denotes outer segment layer
T2157 6846-6851 GO:0007567 denotes natal
T2158 6871-6874 PR_EXT:000005904 denotes Crx
T2159 6874-6875 SO_EXT:normal_or_wild_type_or_present denotes +
T2160 6876-6877 SO_EXT:normal_or_wild_type_or_present denotes +
T2161 6878-6892 CL:0000210 denotes photoreceptors
T2162 6910-6924 GO:0001750 denotes outer segments
T2163 6942-6945 PR_EXT:000005904 denotes Crx
T2164 6945-6946 SO_EXT:sequence_nullness_or_absence denotes -
T2165 6947-6948 SO_EXT:sequence_nullness_or_absence denotes -
T2166 6949-6956 UBERON:0000966 denotes retinas
T2167 6985-6998 GO:0001750 denotes outer segment
T2168 6985-7004 UBERON:0003926 denotes outer segment layer
T2169 7018-7021 PR_EXT:000005904 denotes Crx
T2170 7021-7022 SO_EXT:sequence_nullness_or_absence denotes -
T2171 7023-7024 SO_EXT:sequence_nullness_or_absence denotes -
T2172 7025-7039 CL:0000210 denotes photoreceptors
T2173 7044-7058 GO:0001917 denotes inner segments
T2174 7091-7104 CL:0000210 denotes photoreceptor
T2175 7125-7128 PR_EXT:000005904 denotes Crx
T2176 7129-7135 SO_EXT:sequence_altered_entity denotes mutant
T2177 7145-7159 GO:0001917 denotes inner segments
T2178 7222-7236 GO:0001917 denotes inner segments
T2179 7263-7278 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T2180 7309-7321 GO:0005739 denotes mitochondria
T2181 7372-7385 GO:0001917 denotes inner segment
T2182 7397-7402 GO:0019835 denotes lysis
T2183 7440-7448 GO:0005773 denotes vacuoles
T2184 7461-7473 GO:0005739 denotes mitochondria
T2185 8053-8054 UBERON:0000483 denotes h
T2186 8054-8055 GO:0001750 denotes o
T2187 8055-8056 GO:0001750 denotes t
T2188 8056-8057 UBERON:0001789 denotes o
T2189 8057-8059 UBERON:0001789 denotes re
T2190 8058-8059 GO:0005634 denotes e
T2191 8059-8065 CL:0000210 denotes ceptor
T2192 8066-8067 GO:0005634 denotes i
T2193 8069-8071 CHEBI:10545 denotes er
T2194 8072-8079 GO:0001750 denotes segment
T2195 8072-8079 UBERON:0003926 denotes segment
T2196 8079-8081 _FRAGMENT denotes s
T2197 8081-8082 GO:0005739 denotes a
T2234 10159-10160 SO_EXT:sequence_nullness_or_absence denotes -
T2235 10161-10168 UBERON:0000966 denotes retinas
T2236 10218-10231 GO:0001750 denotes outer segment
T2237 10218-10237 UBERON:0003926 denotes outer segment layer
T2238 10272-10278 GO:0031012 denotes matrix
T2239 10357-10363 GO:0005634 denotes nuclei
T2240 10434-10440 GO:0005634 denotes nuclei
T2241 10450-10458 GO:0030263 denotes pyknotic
T2242 10510-10525 GO:0000792 denotes heterochromatin
T2243 10545-10559 CL:0000210 denotes photoreceptors
T2244 10628-10642 CL:0000210 denotes photoreceptors
T2245 10687-10700 GO:0001750 denotes outer segment
T2246 10687-10706 UBERON:0003926 denotes outer segment layer
T2247 10727-10735 GO:0031982 denotes vesicles
T2248 10819-10833 GO:0001917 denotes inner segments
T2249 10847-10855 CHEBI:10545 denotes electron
T2250 10920-10934 GO:0001917 denotes inner segments
T2251 10992-11008 _FRAGMENT denotes morphogenesis of
T2252 11016-11030 GO:0008594 denotes photoreceptors
T2253 11009-11012 PR_EXT:000005904 denotes Crx
T2254 11012-11013 SO_EXT:sequence_nullness_or_absence denotes -
T2255 11014-11015 SO_EXT:sequence_nullness_or_absence denotes -
T2256 11016-11030 CL:0000210 denotes photoreceptors
T2257 11047-11060 GO:0001750 denotes outer segment
T2258 11047-11066 UBERON:0003926 denotes outer segment layer
T2259 11090-11098 CHEBI:10545 denotes electron
T2260 11144-11147 PR_EXT:000005904 denotes Crx
T2261 11147-11148 SO_EXT:normal_or_wild_type_or_present denotes +
T2262 11149-11150 SO_EXT:normal_or_wild_type_or_present denotes +
T2263 11151-11158 UBERON:0000966 denotes retinas
T2264 11160-11173 CL:0000210 denotes photoreceptor
T2265 11160-11188 GO:0001917 denotes photoreceptor inner segments
T2266 11190-11206 GO:0032391 denotes connecting cilia
T2267 11234-11247 GO:0001750 denotes outer segment
T2268 11284-11287 PR_EXT:000005904 denotes Crx
T2269 11287-11288 SO_EXT:sequence_nullness_or_absence denotes -
T2270 11289-11290 SO_EXT:sequence_nullness_or_absence denotes -
T2271 11291-11297 UBERON:0000966 denotes retina
T2272 11319-11336 GO:0032391 denotes connecting cilium
T2273 11361-11375 GO:0001917 denotes inner segments
T2274 11473-11481 CHEBI:10545 denotes electron
T2275 11567-11570 PR_EXT:000005904 denotes Crx
T2276 11570-11571 SO_EXT:normal_or_wild_type_or_present denotes +
T2277 11572-11573 SO_EXT:normal_or_wild_type_or_present denotes +
T2278 11578-11581 PR_EXT:000005904 denotes Crx
T2279 11581-11582 SO_EXT:sequence_nullness_or_absence denotes -
T2280 11583-11584 SO_EXT:sequence_nullness_or_absence denotes -
T2281 11585-11599 CL:0000210 denotes photoreceptors
T2282 11620-11634 GO:0001750 denotes outer segments
T2283 11649-11652 PR_EXT:000005904 denotes Crx
T2284 11652-11653 SO_EXT:normal_or_wild_type_or_present denotes +
T2285 11654-11655 SO_EXT:normal_or_wild_type_or_present denotes +
T2286 11656-11670 CL:0000210 denotes photoreceptors
T2287 11732-11736 GO:0045177 denotes apex
T2288 11757-11760 PR_EXT:000005904 denotes Crx
T2289 11760-11761 SO_EXT:sequence_nullness_or_absence denotes -
T2290 11762-11763 SO_EXT:sequence_nullness_or_absence denotes -
T2291 11764-11771 UBERON:0000966 denotes retinae
T2292 11794-11808 CL:0000210 denotes photoreceptors
T2293 11836-11852 GO:0032391 denotes connecting cilia
T2294 11861-11875 GO:0001750 denotes outer segments
T2295 11907-11910 PR_EXT:000005904 denotes Crx
T2296 11910-11911 SO_EXT:sequence_nullness_or_absence denotes -
T2297 11912-11913 SO_EXT:sequence_nullness_or_absence denotes -
T2298 11914-11928 CL:0000210 denotes photoreceptors
T2299 11983-12000 GO:0032391 denotes connecting cilium
T2300 12051-12064 GO:0001750 denotes outer segment
T2301 12151-12165 GO:0001750 denotes outer segments
T2302 12192-12195 PR_EXT:000005904 denotes Crx
T2303 12195-12196 SO_EXT:normal_or_wild_type_or_present denotes +
T2304 12197-12198 SO_EXT:normal_or_wild_type_or_present denotes +
T2305 12261-12264 PR_EXT:000005904 denotes Crx
T2306 12264-12265 SO_EXT:sequence_nullness_or_absence denotes -
T2307 12266-12267 SO_EXT:sequence_nullness_or_absence denotes -
T2308 12268-12282 CL:0000210 denotes photoreceptors
T2309 12299-12315 GO:0032391 denotes connecting cilia
T2310 12366-12369 PR_EXT:000005904 denotes Crx
T2311 12369-12370 SO_EXT:sequence_nullness_or_absence denotes -
T2312 12371-12372 SO_EXT:sequence_nullness_or_absence denotes -
T2313 12373-12387 CL:0000210 denotes photoreceptors
T2314 12581-12594 GO:0001750 denotes outer segment
T2315 12612-12615 PR_EXT:000005904 denotes Crx
T2316 12616-12622 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2317 12623-12628 NCBITaxon:10088 denotes mouse
T2318 12667-12680 CL:0000210 denotes photoreceptor
T2319 12681-12690 GO:0042995 denotes appendage
T2320 12718-12731 GO:0001750 denotes outer segment
T2341 14228-14233 SO_EXT:0000704 denotes genes
T2342 14240-14250 GO:0010467 denotes expression
T2343 14268-14281 GO_EXT:negative_regulation denotes downregulated
T2344 14289-14292 PR_EXT:000005904 denotes Crx
T2345 14292-14293 SO_EXT:sequence_nullness_or_absence denotes -
T2346 14294-14295 SO_EXT:sequence_nullness_or_absence denotes -
T2347 14296-14303 UBERON:0000966 denotes retinae
T2348 14333-14342 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2349 14360-14365 SO_EXT:0000704 denotes genes
T2350 14432-14446 GO:0001750 denotes outer segments
T2351 14456-14470 CL:0000210 denotes Photoreceptors
T2352 14486-14492 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2353 14493-14497 NCBITaxon:10088 denotes mice
T2354 14523-14530 UBERON:0001773 denotes scleral
T2355 14563-14566 PR_EXT:000005904 denotes Crx
T2356 14566-14567 SO_EXT:sequence_nullness_or_absence denotes -
T2357 14568-14569 SO_EXT:sequence_nullness_or_absence denotes -
T2358 14570-14584 CL:0000210 denotes photoreceptors
T3575 14860-14863 PR_EXT:000005904 denotes Crx
T3576 14898-14911 CL:0000210 denotes photoreceptor
T3577 14912-14921 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T3578 14971-14981 GO:0010467 denotes expression
T3579 15005-15011 SO_EXT:0001023 denotes allele
T3580 15015-15018 PR_EXT:000005904 denotes Crx
T3581 15033-15037 CL:0000604 denotes rods
T3582 15064-15067 CL:0000604 denotes rod
T3583 15064-15077 GO:0044317 denotes rod spherules
T3584 15085-15106 UBERON:0001790 denotes outer plexiform layer
T3585 15108-15111 UBERON:0001790 denotes OPL
T3586 15117-15131 GO:0001750 denotes outer segments
T3587 15187-15200 CL:0000210 denotes photoreceptor
T3588 15201-15209 GO:0045202 denotes synapses
T3589 15226-15229 PR_EXT:000005904 denotes Crx
T3590 15229-15230 SO_EXT:sequence_nullness_or_absence denotes -
T3591 15231-15232 SO_EXT:sequence_nullness_or_absence denotes -
T3592 15233-15240 UBERON:0000966 denotes retinas
T3593 15245-15248 PR_EXT:000005904 denotes Crx
T3594 15248-15249 SO_EXT:normal_or_wild_type_or_present denotes +
T3595 15250-15251 SO_EXT:normal_or_wild_type_or_present denotes +
T3596 15252-15259 UBERON:0000966 denotes retinas
T3597 15281-15284 CL:0000604 denotes rod
T3598 15281-15294 GO:0044317 denotes rod spherules
T3599 15326-15334 GO:0044317 denotes sperules
T3600 15431-15438 GO:0045202 denotes synapse
T3601 15503-15517 _FRAGMENT denotes processes from
T3602 15529-15534 GO:0042995 denotes cells
T3603 15518-15534 CL:0000745 denotes horizontal cells
T3604 15571-15579 GO:0045202 denotes synaptic
T3605 15626-15635 GO:0030425 denotes dendrites
T3606 15639-15656 CL:0000751 denotes rod bipolar cells
T3607 15651-15656 CL_GO_EXT:cell denotes cells
T3608 15718-15722 CL:0000573 denotes Cone
T3609 15723-15732 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T3610 15749-15757 GO:0044316 denotes pedicles
T3611 15789-15797 GO:0045202 denotes synapses
T3612 15826-15836 _FRAGMENT denotes horizontal
T3613 15849-15853 CL:0000745 denotes cell
T3614 15841-15853 CL:0000103 denotes bipolar cell
T3615 15849-15863 GO:0042995 denotes cell processes
T3616 15870-15877 GO:0044316 denotes pedicle
T3617 15911-15920 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T3618 15948-15957 GO:0044317 denotes spherules
T3619 15961-15964 PR_EXT:000005904 denotes Crx
T3620 15964-15965 SO_EXT:normal_or_wild_type_or_present denotes +
T3621 15966-15967 SO_EXT:normal_or_wild_type_or_present denotes +
T3622 15968-15975 UBERON:0000966 denotes retinas
T3623 16007-16013 _FRAGMENT denotes OPL of
T3624 16021-16028 UBERON:0001790 denotes retinas
T3625 16014-16017 PR_EXT:000005904 denotes Crx
T3626 16017-16018 SO_EXT:sequence_nullness_or_absence denotes -
T3627 16019-16020 SO_EXT:sequence_nullness_or_absence denotes -
T3628 16030-16043 CL:0000210 denotes photoreceptor
T3629 16044-16053 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T3630 16107-16116 GO:0042995 denotes Processes
T3631 16128-16145 GO:0008021 denotes synaptic vesicles
T3632 16230-16248 GO:0044456 denotes synapse components
T3633 16271-16280 GO:0044317 denotes spherules
T3634 16285-16293 GO:0044316 denotes pedicles
T3635 16331-16340 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T3636 16420-16435 GO:0005886 denotes plasma membrane
T3637 16460-16467 GO:0005634 denotes nuclear
T3987 18903-18906 PR_EXT:000005904 denotes Crx
T3988 18906-18907 SO_EXT:sequence_nullness_or_absence denotes -
T3989 18908-18909 SO_EXT:sequence_nullness_or_absence denotes -
T3990 18910-18924 CL:0000210 denotes photoreceptors
T3991 18945-18948 PR_EXT:000005904 denotes Crx
T3992 18949-18958 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T3993 19154-19157 PR_EXT:000005904 denotes Crx
T3994 19157-19158 SO_EXT:sequence_nullness_or_absence denotes -
T3995 19159-19160 SO_EXT:sequence_nullness_or_absence denotes -
T3996 19161-19167 UBERON:0000966 denotes retina
T3997 19194-19207 GO:0001750 denotes outer segment
T3998 19208-19221 GO:0009653 denotes morphogenesis
T3999 19284-19297 GO:0001750 denotes outer segment
T4000 19313-19316 PR_EXT:000005904 denotes Crx
T4001 19316-19317 SO_EXT:sequence_nullness_or_absence denotes -
T4002 19318-19319 SO_EXT:sequence_nullness_or_absence denotes -
T4003 19320-19334 CL:0000210 denotes photoreceptors
T4004 19370-19377 GO:0045202 denotes synapse
T4005 19370-19387 GO:0007416 denotes synapse formation
T4006 19427-19441 GO:0007416 denotes synaptogenesis
T4007 19455-19461 NCBITaxon:33208 denotes animal
T4469 19477-19480 PR_EXT:000005904 denotes Crx
T4470 19480-19481 SO_EXT:sequence_nullness_or_absence denotes -
T4471 19482-19483 SO_EXT:sequence_nullness_or_absence denotes -
T4472 19484-19498 CL:0000210 denotes photoreceptors
T4473 19515-19528 GO:0001750 denotes outer segment
T4474 19529-19542 GO:0009653 denotes morphogenesis
T4475 19543-19552 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T4476 19556-19559 PR_EXT:000005904 denotes Crx
T4477 19593-19597 SO_EXT:0000704 denotes gene
T4478 19598-19607 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T4479 19624-19637 GO:0001750 denotes outer segment
T4480 19667-19671 SO_EXT:sequence_nullness denotes null
T4481 19672-19681 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T4482 19689-19699 PR_EXT:peripherin denotes peripherin
T4483 19700-19703 PR_EXT:000013290 denotes RDS
T4484 19704-19708 SO_EXT:0000704 denotes gene
T4485 19720-19729 PR_EXT:000001245 denotes rhodopsin
T4486 19756-19769 GO:0001750 denotes outer segment
T4487 19797-19807 PR_EXT:peripherin denotes peripherin
T4488 19807-19808 SO_EXT:sequence_nullness_or_absence denotes -
T4489 19809-19810 SO_EXT:sequence_nullness_or_absence denotes -
T4490 19815-19818 PR_EXT:000005904 denotes Crx
T4491 19818-19819 SO_EXT:sequence_nullness_or_absence denotes -
T4492 19820-19821 SO_EXT:sequence_nullness_or_absence denotes -
T4493 19822-19835 CL:0000210 denotes photoreceptor
T4494 19822-19849 GO:0008594 denotes photoreceptor morphogenesis
T4495 19881-19890 GO:0031982 denotes Vesicular
T4496 19905-19908 PR_EXT:000005904 denotes Crx
T4497 19908-19909 SO_EXT:sequence_nullness_or_absence denotes -
T4498 19910-19911 SO_EXT:sequence_nullness_or_absence denotes -
T4499 19912-19926 CL:0000210 denotes photoreceptors
T4500 19992-19995 PR_EXT:000013290 denotes rds
T4501 19996-20006 PR_EXT:peripherin denotes peripherin
T4502 20006-20007 SO_EXT:sequence_nullness_or_absence denotes -
T4503 20008-20009 SO_EXT:sequence_nullness_or_absence denotes -
T4504 20010-20015 NCBITaxon:10088 denotes mouse
T4505 20054-20062 GO:0031982 denotes vesicles
T4506 20079-20091 _FRAGMENT denotes breakdown of
T4507 20106-20115 GO:0030397 denotes membranes
T4508 20092-20115 GO:0042622 denotes outer segment membranes
T4509 20139-20148 GO_EXT:biological_recruitment denotes recruited
T4510 20156-20170 GO:0001750 denotes outer segments
T4511 20189-20199 PR_EXT:peripherin denotes peripherin
T4512 20249-20259 GO:0005902 denotes microvilli
T4513 20263-20275 CL:0000636 denotes Müller cells
T4514 20270-20275 CL_GO_EXT:cell denotes cells
T4515 20400-20409 PR_EXT:000001245 denotes rhodopsin
T4516 20410-20417 CHEBI_PR_EXT:protein denotes protein
T4517 20427-20435 GO:0031982 denotes vesicles
T4518 20478-20487 PR_EXT:000001245 denotes rhodopsin
T4519 20488-20495 CHEBI_SO_EXT:epitope denotes epitope
T4520 20530-20538 GO:0031982 denotes vesicles
T4521 20562-20576 GO:0001917 denotes inner segments
T4522 20603-20617 CL:0000210 denotes photoreceptors
T4523 20636-20642 GO_EXT:biological_growth_entity_or_process denotes growth
T4524 20670-20683 GO:0001750 denotes outer segment
T4525 20714-20731 GO:0032391 denotes connecting cilium
T4526 20767-20777 PR_EXT:peripherin denotes Peripherin
T4527 20778-20781 PR_EXT:000013290 denotes RDS
T4528 20786-20791 PR_EXT:000014157 denotes ROM-1
T4529 20792-20800 CHEBI_PR_EXT:protein denotes proteins
T4530 20802-20811 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4531 20834-20839 PR_EXT:000001119 denotes opsin
T4532 20840-20848 CHEBI_PR_EXT:protein denotes proteins
T4533 20850-20859 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4534 20941-20955 GO:0001750 denotes outer segments
T4535 20971-20976 PR_EXT:000014157 denotes ROM-1
T4536 20976-20977 SO_EXT:sequence_nullness_or_absence denotes -
T4537 20978-20979 SO_EXT:sequence_nullness_or_absence denotes -
T4538 20980-20984 NCBITaxon:10088 denotes mice
T4539 21006-21020 GO:0001750 denotes outer segments
T4540 21044-21047 PR_EXT:000005904 denotes Crx
T4541 21070-21083 GO_EXT:transcription denotes transcription
T4542 21070-21090 GO_EXT:transcription_factor denotes transcription factor
T4543 21103-21111 GO:0065007 denotes controls
T4544 21112-21117 SO_EXT:0000704 denotes genes
T4545 21187-21200 GO:0001750 denotes outer segment
T4546 21222-21231 PR_EXT:000001245 denotes rhodopsin
T4547 21236-21246 PR_EXT:peripherin denotes peripherin
T4548 21316-21320 SO_EXT:0000704 denotes gene
T4549 21316-21331 GO:0010467 denotes gene expression
T4550 21379-21384 SO_EXT:0000704 denotes genes
T4551 21411-21421 GO:0010467 denotes expression
T4552 21431-21434 PR_EXT:000005904 denotes Crx
T4553 21434-21435 SO_EXT:sequence_nullness_or_absence denotes -
T4554 21436-21437 SO_EXT:sequence_nullness_or_absence denotes -
T4555 21438-21442 NCBITaxon:10088 denotes mice
T4556 21458-21467 PR_EXT:000001245 denotes rhodopsin
T4557 21468-21478 GO:0010467 denotes expression
T4558 21506-21509 PR_EXT:000005904 denotes Crx
T4559 21509-21510 SO_EXT:sequence_nullness_or_absence denotes -
T4560 21511-21512 SO_EXT:sequence_nullness_or_absence denotes -
T4561 21513-21520 NCBITaxon:33208 denotes animals
T4562 21526-21536 PR_EXT:peripherin denotes peripherin
T4563 21537-21541 CHEBI_SO_EXT:mRNA denotes mRNA
T4564 21576-21586 SO_EXT:transgenic_entity denotes Transgenic
T4565 21587-21591 NCBITaxon:10088 denotes mice
T4566 21616-21626 GO:0010467 denotes expression
T4567 21630-21639 SO_EXT:wild_type_entity_or_quality denotes wild type
T4568 21640-21649 PR_EXT:000001245 denotes rhodopsin
T4569 21658-21661 CL:0000604 denotes rod
T4570 21723-21732 PR_EXT:000001245 denotes rhodopsin
T4571 21733-21743 GO:0010467 denotes expression
T4572 21772-21781 PR_EXT:000001245 denotes rhodopsin
T4573 21782-21792 GO:0010467 denotes expression
T4574 21843-21853 NCBITaxon:7215 denotes Drosophila
T4575 21858-21868 NCBITaxon:7215 denotes Drosophila
T4576 21870-21879 PR_EXT:000001245 denotes rhodopsin
T4577 21881-21886 PR_EXT:P06002 denotes ninaE
T4578 21891-21900 GO:0010467 denotes expressed
T4579 21904-21921 CL:0000687 denotes photoreceptors R1
T4580 21904-21918 _FRAGMENT denotes photoreceptors
T4581 21922-21924 CL:0000705 denotes R6
T4582 21929-21934 PR_EXT:P06002 denotes ninaE
T4583 21935-21939 SO_EXT:sequence_nullness denotes null
T4584 21940-21947 SO_EXT:sequence_altered_entity denotes mutants
T4585 21953-21963 GO:0016028 denotes rhabdomere
T4586 21990-22000 NCBITaxon:7742 denotes vertebrate
T4587 22001-22015 GO:0001750 denotes outer segments
T4588 22037-22039 _FRAGMENT denotes R1
T4589 22043-22057 CL:0000687 denotes photoreceptors
T4590 22040-22057 CL:0000705 denotes R6 photoreceptors
T4591 22096-22105 PR_EXT:000001245 denotes rhodopsin
T4592 22105-22106 SO_EXT:sequence_nullness_or_absence denotes -
T4593 22107-22108 SO_EXT:sequence_nullness_or_absence denotes -
T4594 22109-22113 NCBITaxon:10088 denotes mice
T4595 22206-22215 PR_EXT:000001245 denotes rhodopsin
T4596 22216-22226 GO:0010467 denotes expression
T4597 22234-22244 GO:0016028 denotes rhabdomere
T4598 22234-22256 GO:0042052 denotes rhabdomere development
T4599 22261-22266 PR_EXT:P06002 denotes ninaE
T4600 22267-22271 SO_EXT:sequence_nullness denotes null
T4601 22272-22277 NCBITaxon:7147 denotes flies
T4602 22281-22286 PR_EXT:P06002 denotes ninaE
T4603 22287-22296 SO_EXT:0000902 denotes transgene
T4604 22307-22314 GO:0065007 denotes control
T4605 22331-22339 SO_EXT:0000167 denotes promoter
T4606 22441-22450 PR_EXT:000001245 denotes rhodopsin
T4607 22498-22504 SO_EXT:sequence_rescue_process denotes rescue
T4608 22508-22521 CL:0000210 denotes photoreceptor
T4609 22546-22552 SO_EXT:sequence_rescue_process denotes rescue
T4610 22556-22569 CL:0000210 denotes photoreceptor
T4611 22570-22580 GO_PATO_EXT:physiological_process_or_quality denotes physiology
T4612 22591-22601 GO:0010467 denotes expression
T4613 22657-22663 SO_EXT:sequence_rescue_process denotes rescue
T4614 22681-22690 PR_EXT:000001245 denotes rhodopsin
T4615 22691-22701 GO:0010467 denotes expression
T4616 22774-22784 GO:0016028 denotes rhabdomere
T4617 22774-22798 GO:0061541 denotes rhabdomere morphogenesis
T4618 22851-22854 NCBITaxon:10114 denotes rat
T4619 22863-22872 PR_EXT:000001245 denotes rhodopsin
T4620 22942-22946 CL:0000604 denotes rods
T4621 22979-22989 GO:0065007 denotes regulation
T4622 22993-23002 PR_EXT:000001245 denotes rhodopsin
T4623 23030-23037 GO:0065007 denotes control
T4624 23061-23074 GO_EXT:positive_regulation denotes up-regulation
T4625 23078-23087 PR_EXT:000001245 denotes rhodopsin
T4626 23111-23114 PR_EXT:000005904 denotes Crx
T4627 23122-23132 GO:0065007 denotes regulating
T4628 23133-23146 GO:0001750 denotes outer segment
T4629 23147-23160 GO:0009653 denotes morphogenesis
T4630 23237-23240 PR_EXT:000005904 denotes Crx
T4631 23253-23263 NCBITaxon:7215 denotes Drosophila
T4632 23267-23270 PR_EXT:P22810 denotes Otd
T4633 23317-23322 SO_EXT:0000704 denotes genes
T4634 23332-23335 PR_EXT:000005904 denotes Crx
T4635 23379-23385 SO_EXT:0001023 denotes allele
T4636 23389-23399 NCBITaxon:7215 denotes Drosophila
T4637 23400-23403 PR_EXT:P22810 denotes otd
T4638 23405-23408 PR_EXT:P22810 denotes otd
T4639 23413-23426 CL:0000210 denotes photoreceptor
T4640 23413-23440 GO:0008594 denotes photoreceptor morphogenesis
T4641 23500-23505 SO_EXT:0000704 denotes genes
T4642 23530-23533 PR_EXT:000005904 denotes Crx
T4643 23550-23559 GO:0010467 denotes expressed
T4644 23584-23587 PR_EXT:000005904 denotes Crx
T4645 23587-23588 SO_EXT:sequence_nullness_or_absence denotes -
T4646 23589-23590 SO_EXT:sequence_nullness_or_absence denotes -
T4647 23591-23597 UBERON:0000966 denotes retina
T4648 23607-23616 PR_EXT:000001245 denotes rhodopsin
T4649 23621-23631 PR_EXT:peripherin denotes peripherin
T4650 23687-23701 CL:0000210 denotes photoreceptors
T4651 23711-23721 GO:0010467 denotes expression
T4652 23741-23748 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T4653 23771-23776 CHEBI:18059 denotes lipid
T4654 23771-23787 GO:0006629 denotes lipid metabolism
T4655 23789-23796 CHEBI_PR_EXT:protein denotes protein
T4656 23789-23804 GO:0006457 denotes protein folding
T4657 23809-23818 GO_EXT:biological_routing_or_transport denotes transport
T4658 23929-23942 GO:0001750 denotes outer segment
T4659 23952-23965 GO:0097617 denotes hybridization
T4660 23972-23978 CHEBI_SO_EXT:molecular_probe denotes probes
T4661 24003-24008 SO_EXT:0000704 denotes genes
T4662 24051-24054 CHEBI_SO_EXT:RNA denotes RNA
T4663 24055-24064 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T4664 24072-24085 GO:0001917 denotes inner segment
T4665 24109-24117 CHEBI_PR_EXT:protein denotes proteins
T4666 24118-24126 GO_EXT:biological_routing_or_transport denotes targeted
T4667 24134-24147 GO:0001750 denotes outer segment
T4668 24190-24195 SO_EXT:0000704 denotes genes
T4669 24223-24236 GO:0001750 denotes outer segment
T4670 24237-24247 GO_EXT:biogenesis_or_biosynthesis denotes biogenesis
T4671 24274-24288 CL:0000210 denotes photoreceptors
T4672 24328-24340 GO:0042384 denotes ciliogenesis
T4673 24354-24358 SO_EXT:0000704 denotes gene
T4674 24360-24364 PR_EXT:000005848 denotes CRB1
T4675 24380-24384 SO_EXT:0000704 denotes gene
T4676 24385-24389 PR_EXT:000005850 denotes CRB3
T4677 24415-24427 GO:0042384 denotes ciliogenesis
T4678 24457-24467 NCBITaxon:7215 denotes Drosophila
T4679 24468-24477 SO_EXT:0000853 denotes homologue
T4680 24481-24485 PR_EXT:000005848 denotes CRB1
T4681 24487-24493 PR_EXT:P10040 denotes Crumbs
T4682 24518-24531 CL:0000210 denotes photoreceptor
T4683 24518-24545 GO:0008594 denotes photoreceptor morphogenesis
T4684 24589-24594 NCBITaxon:10088 denotes mouse
T4685 24595-24601 SO_EXT:sequence_altered_entity denotes mutant
T4686 24605-24609 PR_EXT:000005848 denotes CRB1
T4687 24619-24624 NCBITaxon:10088 denotes mouse
T4688 24645-24659 GO:0001750 denotes outer segments
T4689 24711-24724 CL:0000210 denotes photoreceptor
T4690 24742-24756 GO:0007416 denotes synaptogenesis
T4691 24776-24782 SO_EXT:sequence_altered_entity denotes mutant
T4692 24790-24794 PR_EXT:000005848 denotes CRB1
T4693 24799-24802 PR_EXT:000005904 denotes Crx
T4694 24903-24910 UBERON:0000966 denotes retinal
T4695 24903-24922 GO:0060041 denotes retinal development
T5991 24925-24939 GO:0007416 denotes Synaptogenesis
T5992 24956-24959 PR_EXT:000005904 denotes Crx
T5993 24959-24960 SO_EXT:sequence_nullness_or_absence denotes -
T5994 24961-24962 SO_EXT:sequence_nullness_or_absence denotes -
T5995 24963-24977 CL:0000210 denotes photoreceptors
T5996 24982-24985 PR_EXT:000005904 denotes Crx
T5997 24985-24986 SO_EXT:sequence_nullness_or_absence denotes -
T5998 24987-24988 SO_EXT:sequence_nullness_or_absence denotes -
T5999 24989-24994 NCBITaxon:10088 denotes mouse
T6000 25039-25052 CL:0000210 denotes photoreceptor
T6001 25053-25061 GO:0045202 denotes synapses
T6002 25084-25094 PR_EXT:peripherin denotes peripherin
T6003 25094-25095 SO_EXT:sequence_nullness_or_absence denotes -
T6004 25096-25097 SO_EXT:sequence_nullness_or_absence denotes -
T6005 25098-25103 NCBITaxon:10088 denotes mouse
T6006 25136-25149 CL:0000210 denotes photoreceptor
T6007 25150-25159 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6008 25189-25203 CL:0000210 denotes photoreceptors
T6009 25238-25247 PR_EXT:000001245 denotes rhodopsin
T6010 25249-25252 PR_EXT:000001245 denotes Rho
T6011 25258-25275 CHEBI:23447 denotes cyclic nucleotide
T6012 25258-25298 PR_EXT:000000696 denotes cyclic nucleotide-gated channel, alpha-3
T6013 25276-25289 GO_EXT:0022836 denotes gated channel
T6014 25300-25305 PR_EXT:000000696 denotes CNGA3
T6015 25323-25327 NCBITaxon:10088 denotes mice
T6016 25329-25332 PR_EXT:000001245 denotes Rho
T6017 25332-25333 SO_EXT:sequence_nullness_or_absence denotes -
T6018 25334-25335 SO_EXT:sequence_nullness_or_absence denotes -
T6019 25337-25342 PR_EXT:000000696 denotes CNGA3
T6020 25342-25343 SO_EXT:sequence_nullness_or_absence denotes -
T6021 25344-25345 SO_EXT:sequence_nullness_or_absence denotes -
T6022 25348-25356 GO:0045202 denotes synapses
T6023 25429-25442 CL:0000210 denotes photoreceptor
T6024 25443-25457 GO:0007416 denotes synaptogenesis
T6025 25486-25499 GO:0001750 denotes outer segment
T6026 25607-25617 PR_EXT:peripherin denotes peripherin
T6027 25617-25618 SO_EXT:sequence_nullness_or_absence denotes -
T6028 25619-25620 SO_EXT:sequence_nullness_or_absence denotes -
T6029 25621-25625 NCBITaxon:10088 denotes mice
T6030 25651-25668 GO:0007602 denotes phototransduction
T6031 25689-25693 NCBITaxon:10088 denotes mice
T6032 25727-25740 CL:0000210 denotes photoreceptor
T6033 25741-25748 GO:0045202 denotes synapse
T6034 25775-25791 GO:0044456 denotes synapse elements
T6035 25828-25841 GO:0001750 denotes outer segment
T6036 25906-25919 CL:0000210 denotes photoreceptor
T6037 25965-25982 GO:0007602 denotes phototransduction
T6038 25987-25994 GO:0045202 denotes synapse
T6039 25987-26004 GO:0007416 denotes synapse formation
T6040 26094-26097 PR_EXT:000005904 denotes Crx
T6041 26097-26098 SO_EXT:sequence_nullness_or_absence denotes -
T6042 26099-26100 SO_EXT:sequence_nullness_or_absence denotes -
T6043 26101-26115 CL:0000210 denotes photoreceptors
T6044 26135-26143 GO:0045202 denotes synaptic
T6045 26144-26151 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes endings
T6046 26176-26189 GO:0001750 denotes outer segment
T6047 26235-26238 PR_EXT:000005904 denotes Crx
T6048 26255-26268 CL:0000210 denotes photoreceptor
T6049 26269-26276 GO:0045202 denotes synapse
T6050 26269-26286 GO:0007416 denotes synapse formation
T6051 26299-26309 GO:0065007 denotes regulating
T6052 26345-26350 SO_EXT:0000704 denotes genes
T6053 26412-26422 GO:0010467 denotes expression
T6054 26433-26445 GO:0098793 denotes pre-synaptic
T6055 26446-26454 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6056 26455-26463 CHEBI_PR_EXT:protein denotes proteins
T6057 26475-26480 PR_EXT:000009311 denotes KIF3a
T6058 26482-26485 PR_EXT:000015849 denotes SV2
T6059 26491-26504 PR_EXT:000015890 denotes synaptophysin
T6060 26565-26568 PR_EXT:000005904 denotes Crx
T6061 26568-26569 SO_EXT:sequence_nullness_or_absence denotes -
T6062 26570-26571 SO_EXT:sequence_nullness_or_absence denotes -
T6063 26584-26590 UBERON:0000479 denotes tissue
T6064 26637-26640 CHEBI_SO_EXT:RNA denotes RNA
T6065 26699-26704 SO_EXT:0000704 denotes genes
T6066 26722-26726 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes tags
T6067 26753-26758 SO_EXT:0000704 denotes genes
T6068 26784-26787 CHEBI_SO_EXT:RNA denotes RNA
T6069 26845-26850 SO_EXT:0000704 denotes genes
T6070 26851-26860 GO:0010467 denotes expressed
T6071 26864-26878 CL:0000210 denotes photoreceptors
T6072 26915-26925 GO:0010467 denotes expression
T6073 26939-26942 PR_EXT:000005904 denotes Crx
T6074 26942-26943 SO_EXT:sequence_nullness_or_absence denotes -
T6075 26944-26945 SO_EXT:sequence_nullness_or_absence denotes -
T6076 26946-26951 NCBITaxon:10088 denotes mouse
T6077 27007-27020 CL:0000210 denotes photoreceptor
T6078 27007-27034 GO:0008594 denotes photoreceptor morphogenesis
T6079 27036-27040 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes Tags
T6080 27052-27057 SO_EXT:0000704 denotes genes
T6081 27063-27071 CHEBI_PR_EXT:protein denotes proteins
T6082 27072-27081 GO:0010467 denotes expressed
T6083 27085-27098 CL:0000210 denotes photoreceptor
T6084 27099-27108 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6085 27187-27226 PR_EXT:000008536 denotes HGF-regulated tyrosine kinase substrate
T6086 27191-27200 GO:0065007 denotes regulated
T6087 27201-27209 CHEBI_SO_EXT:tyrosine denotes tyrosine
T6088 27201-27216 GO_EXT:0004713 denotes tyrosine kinase
T6089 27232-27237 PR_EXT:000005877 denotes CRIPT
T6090 27238-27245 CHEBI_PR_EXT:protein denotes protein
T6091 27251-27266 PR_EXT:000015894 denotes synaptotagmin 1
T6092 27324-27328 SO_EXT:0000704 denotes gene
T6093 27355-27358 PR_EXT:000005904 denotes Crx
T6094 27358-27359 SO_EXT:sequence_nullness_or_absence denotes -
T6095 27360-27361 SO_EXT:sequence_nullness_or_absence denotes -
T6096 27362-27368 UBERON:0000966 denotes retina
T6097 27372-27376 PR_EXT:000017084 denotes HRG4
T6098 27380-27389 SO_EXT:0000853 denotes homologue
T6099 27397-27407 NCBITaxon:6239 denotes C. elegans
T6100 27408-27414 PR_EXT:Q10658 denotes Unc119
T6101 27415-27419 SO_EXT:0000704 denotes gene
T6102 27467-27474 SO_EXT:sequence_coding_function denotes encodes
T6103 27494-27508 GO:0097470 denotes ribbon synapse
T6104 27535-27546 GO_EXT:positive_regulation denotes upregulated
T6105 27564-27572 GO_EXT:reaction_or_response denotes response
T6106 27595-27603 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6107 27630-27635 SO_EXT:0000704 denotes genes
T6108 27636-27644 SO_EXT:sequence_coding_function denotes encoding
T6109 27654-27675 GO:0044430 denotes cytoskeletal elements
T6110 27702-27713 GO:0005874 denotes microtubule
T6111 27702-27734 PR_EXT:000010142 denotes microtubule associated protein 4
T6112 27725-27732 CHEBI_PR_EXT:protein denotes protein
T6113 27755-27764 PR_EXT:000005385 denotes cofilin 1
T6114 27773-27776 PR_EXT:000005904 denotes Crx
T6115 27776-27777 SO_EXT:sequence_nullness_or_absence denotes -
T6116 27778-27779 SO_EXT:sequence_nullness_or_absence denotes -
T6117 27780-27786 UBERON:0000966 denotes retina
T6118 27849-27854 SO_EXT:0000704 denotes genes
T6119 27883-27893 GO:0065007 denotes regulating
T6120 27894-27902 GO:0045202 denotes synaptic
T6121 27932-27937 SO_EXT:0000704 denotes genes
T6122 28055-28069 GO:0097470 denotes ribbon synapse
T6123 28080-28093 CL:0000210 denotes photoreceptor
T6124 28094-28102 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T6125 28148-28155 UBERON:0000966 denotes retinal
T6126 28148-28167 GO:0060041 denotes retinal development
T6127 28175-28194 PR_EXT:000009655 denotes laminin beta2 chain
T6128 28205-28210 NCBITaxon:10088 denotes mouse
T6129 28257-28261 NCBITaxon:10088 denotes mice
T6130 28270-28289 PR_EXT:000009655 denotes laminin beta2 chain
T6131 28300-28304 NCBITaxon:10088 denotes mice
T6132 28324-28337 GO:0001750 denotes outer segment
T6133 28393-28396 PR_EXT:000005904 denotes Crx
T6134 28396-28397 SO_EXT:sequence_nullness_or_absence denotes -
T6135 28398-28399 SO_EXT:sequence_nullness_or_absence denotes -
T6136 28400-28404 NCBITaxon:10088 denotes mice
T6137 28410-28424 GO:0001750 denotes outer segments
T6138 28461-28474 CL:0000210 denotes photoreceptor
T6139 28475-28484 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T6140 28503-28516 PR_EXT:000009655 denotes laminin beta2
T6141 28517-28524 SO_EXT:sequence_altered_entity denotes mutants
T6142 28579-28582 PR_EXT:000005904 denotes Crx
T6143 28582-28583 SO_EXT:sequence_nullness_or_absence denotes -
T6144 28584-28585 SO_EXT:sequence_nullness_or_absence denotes -
T6145 28586-28590 NCBITaxon:10088 denotes mice
T6146 28596-28620 _FRAGMENT denotes outer plexiform layer of
T6147 28641-28648 UBERON:0001790 denotes retinas
T6148 28625-28630 PR_EXT:000009655 denotes beta2
T6149 28690-28698 GO:0045202 denotes synapses
T6150 28764-28772 GO:0045202 denotes synaptic
T6151 28838-28847 CHEBI:36357 denotes molecules
T6152 28860-28873 CL:0000210 denotes photoreceptor
T6153 28860-28887 GO:0008594 denotes photoreceptor morphogenesis
T6154 28912-28916 CHEBI_SO_EXT:mRNA denotes mRNA
T6155 28921-28934 PR_EXT:000009655 denotes laminin beta2
T6156 28986-28989 CHEBI_SO_EXT:RNA denotes RNA
T6157 29000-29003 PR_EXT:000005904 denotes Crx
T6158 29003-29004 SO_EXT:sequence_nullness_or_absence denotes -
T6159 29005-29006 SO_EXT:sequence_nullness_or_absence denotes -
T6160 29011-29014 PR_EXT:000005904 denotes Crx
T6161 29014-29015 SO_EXT:normal_or_wild_type_or_present denotes +
T6162 29016-29017 SO_EXT:normal_or_wild_type_or_present denotes +
T6163 29070-29073 CHEBI_SO_EXT:RNA denotes RNA
T6164 29078-29091 PR_EXT:000009655 denotes laminin beta2
T7081 29107-29110 PR_EXT:000005904 denotes Crx
T7082 29110-29111 SO_EXT:sequence_nullness_or_absence denotes -
T7083 29112-29113 SO_EXT:sequence_nullness_or_absence denotes -
T7084 29114-29118 NCBITaxon:10088 denotes mice
T7085 29139-29142 PR_EXT:000005904 denotes Crx
T7086 29172-29185 CL:0000210 denotes photoreceptor
T7087 29210-29215 NCBITaxon:9606 denotes human
T7088 29227-29231 CL:0000573 denotes cone
T7089 29232-29235 CL:0000604 denotes rod
T7090 29331-29335 CL:0000573 denotes cone
T7091 29336-29339 CL:0000604 denotes rod
T7092 29388-29392 CL:0000573 denotes cone
T7093 29402-29408 GO:0007601 denotes vision
T7094 29432-29436 UBERON:0000104 denotes life
T7095 29486-29489 CL:0000604 denotes rod
T7096 29499-29505 GO:0007601 denotes vision
T7097 29558-29561 CL:0000604 denotes rod
T7098 29592-29596 CL:0000573 denotes cone
T7099 29606-29612 GO:0007601 denotes vision
T7100 29641-29646 SO_EXT:0000704 denotes genes
T7101 29663-29668 NCBITaxon:9606 denotes human
T7102 29669-29676 SO_EXT:0000704 denotes genetic
T7103 29688-29694 SO_EXT:sequence_coding_function denotes encode
T7104 29695-29703 CHEBI_PR_EXT:protein denotes proteins
T7105 29704-29713 GO:0010467 denotes expressed
T7106 29753-29767 CL:0000210 denotes photoreceptors
T7107 29789-29802 GO:0001750 denotes outer segment
T7108 29823-29831 CHEBI_PR_EXT:protein denotes proteins
T7109 29849-29866 GO:0007602 denotes phototransduction
T7110 29870-29883 GO:0001750 denotes outer segment
T7111 29918-29927 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7112 29931-29934 CL:0000604 denotes rod
T7113 29944-29949 SO_EXT:0000704 denotes genes
T7114 29959-29968 PR_EXT:000001245 denotes rhodopsin
T7115 29989-29993 CL:0000573 denotes cone
T7116 30029-30038 SO_EXT:sequence_alteration_entity_or_process denotes Mutations
T7117 30042-30045 PR_EXT:000005904 denotes Crx
T7118 30104-30117 GO_EXT:transcription denotes transcription
T7119 30104-30124 GO_EXT:transcription_factor denotes transcription factor
T7120 30125-30133 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T7121 30145-30158 CL:0000210 denotes photoreceptor
T7122 30216-30229 CL:0000210 denotes photoreceptor
T7123 30319-30322 PR_EXT:000005904 denotes Crx
T7124 30322-30323 SO_EXT:sequence_nullness_or_absence denotes -
T7125 30324-30325 SO_EXT:sequence_nullness_or_absence denotes -
T7126 30326-30331 NCBITaxon:10088 denotes mouse
T7127 30450-30453 PR_EXT:000005904 denotes Crx
T7128 30454-30463 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7129 30535-30540 NCBITaxon:9606 denotes human
T7130 30541-30547 UBERON:0000479 denotes tissue
T7131 30571-30576 UBERON:0007023 denotes adult
T7132 30655-30661 NCBITaxon:33208 denotes animal
T7133 30755-30767 _FRAGMENT denotes formation of
T7134 30776-30782 GO:0009888 denotes tissue
T7135 30768-30775 UBERON:0000966 denotes retinal
T7136 30776-30782 UBERON:0000479 denotes tissue
T7137 30807-30812 NCBITaxon:9606 denotes human
T7138 30813-30819 UBERON:0000479 denotes tissue
T7139 30835-30840 NCBITaxon:9606 denotes human
T7140 30849-30855 UBERON:0000966 denotes retina
T7141 30870-30875 PR_EXT:000014179 denotes RPE65
T7142 30876-30885 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7143 30916-30923 UBERON:0000966 denotes retinae
T7144 30971-30975 CL_GO_EXT:cell denotes cell
T7145 31008-31021 CL:0000210 denotes photoreceptor
T7146 31008-31027 UBERON:0001787 denotes photoreceptor layer
T7147 31087-31095 GO:0045202 denotes synaptic
T7148 31106-31113 UBERON:0000966 denotes retinal
T7149 31158-31171 CL:0000210 denotes photoreceptor
T7150 31172-31180 GO:0045202 denotes synapses
T7151 31279-31284 NCBITaxon:9606 denotes human
T7152 31285-31291 UBERON:0000479 denotes tissue
T7153 31359-31365 NCBITaxon:33208 denotes animal
T7154 31444-31457 GO:0001750 denotes outer segment
T7155 31458-31471 GO:0009653 denotes morphogenesis
T7156 31473-31487 GO:0007416 denotes synaptogenesis
T7745 31763-31771 CHEBI:10545 denotes electron
T7746 31794-31797 PR_EXT:000005904 denotes Crx
T7747 31797-31798 SO_EXT:sequence_nullness_or_absence denotes -
T7748 31799-31800 SO_EXT:sequence_nullness_or_absence denotes -
T7749 31805-31813 SO_EXT:wild_type_entity_or_quality denotes wildtype
T7750 31814-31818 NCBITaxon_UBERON_EXT:pup denotes pups
T7751 31839-31851 CHEBI:16842 denotes formaldehyde
T7752 31861-31875 CHEBI:64276 denotes glutaraldehyde
T7753 31891-31896 GO:0007567 denotes natal
T7754 31909-31913 UBERON:0000970 denotes eyes
T7755 31944-31950 UBERON:0000964 denotes cornea
T7756 31955-31959 UBERON_EXT:lens denotes lens
T7757 31978-31981 UBERON:0000970 denotes eye
T7758 32002-32010 CHEBI_EXT:50913 denotes fixative
T7759 32015-32027 CHEBI:16842 denotes formaldehyde
T7760 32037-32051 CHEBI:64276 denotes glutaraldehyde
T7761 32082-32088 UBERON:0001773 denotes sclera
T7762 32124-32131 UBERON:0000966 denotes retinas
T7763 32176-32192 CHEBI_EXT:paraformaldehye denotes paraformaldehyde
T7764 32202-32216 CHEBI:64276 denotes glutaraldehyde
T7765 32320-32333 CL:0000210 denotes photoreceptor
T7766 32320-32348 GO:0001750 denotes photoreceptor outer segments
T7767 32368-32374 UBERON:0000479 denotes tissue
T7768 32429-32435 UBERON:0000479 denotes tissue
T7769 32485-32507 CHEBI:30059 denotes potassium ferrocyanide
T7770 32508-32515 CHEBI:60004 denotes mixture
T7771 32600-32607 CHEBI_EXT:maleate denotes maleate
T7772 32608-32614 CHEBI_CHMO_EXT:buffer_solution denotes buffer
T7773 32661-32672 CHEBI:75211 denotes tannic acid
T7774 32682-32692 CHEBI:16223 denotes cacodylate
T7775 32693-32699 CHEBI_CHMO_EXT:buffer_solution denotes buffer
T7776 32848-32852 CHEBI_EXT:lead denotes lead
T7777 32853-32860 CHEBI_EXT:citrate denotes citrate
T7778 32896-32904 CHEBI:10545 denotes electron
T8047 32927-32935 CHEBI:10545 denotes electron
T8048 32994-33020 UBERON:0001782 denotes retinal pigment epithelium
T8049 33078-33091 UBERON:0003902 denotes neural retina
T8050 33093-33100 UBERON:0000966 denotes Retinae
T8051 33106-33109 PR_EXT:000005904 denotes Crx
T8052 33109-33110 SO_EXT:sequence_nullness_or_absence denotes -
T8053 33111-33112 SO_EXT:sequence_nullness_or_absence denotes -
T8054 33114-33123 PR_EXT:000001245 denotes rhodopsin
T8055 33123-33124 SO_EXT:sequence_nullness_or_absence denotes -
T8056 33125-33126 SO_EXT:sequence_nullness_or_absence denotes -
T8057 33128-33131 PR_EXT:000013290 denotes RDS
T8058 33136-33144 SO_EXT:wild_type_entity_or_quality denotes wildtype
T8059 33145-33149 UBERON:0000970 denotes eyes
T8060 33191-33199 CHEBI:75958 denotes solution
T8061 33219-33233 CHEBI:64276 denotes glutaraldehyde
T8062 33243-33255 CHEBI:16842 denotes formaldehyde
T8063 33274-33280 UBERON:0000479 denotes Tissue
T8064 33303-33313 CHEBI:16223 denotes cacodylate
T8065 33314-33320 CHEBI_CHMO_EXT:buffer_solution denotes buffer
T8066 33359-33366 CHEBI:16236 denotes ethanol
T8067 33368-33375 UBERON:0000479 denotes Tissues
T8068 33418-33432 CHEBI:16526 denotes carbon dioxide
T8069 33488-33492 CHEBI_EXT:gold denotes gold
T8070 33493-33502 CHEBI_EXT:palladium denotes palladium
T8071 33588-33596 CHEBI:10545 denotes electron
T8245 7666-7669 UBERON:0001789 denotes onl
T8246 7671-7690 UBERON:0001789 denotes outer nuclear layer
T8247 7677-7684 GO:0005634 denotes nuclear
T8248 7696-7709 CL:0000210 denotes photoreceptor
T8249 7710-7716 GO:0005634 denotes nuclei
T8347 7771-7779 CHEBI:10545 denotes electron
T8348 7798-7811 GO:0001750 denotes outer segment
T8349 7798-7817 UBERON:0003926 denotes outer segment layer
T8350 7821-7824 PR_EXT:000005904 denotes Crx
T8351 7824-7825 SO_EXT:sequence_nullness_or_absence denotes -
T8352 7826-7827 SO_EXT:sequence_nullness_or_absence denotes -
T8353 7828-7834 UBERON:0000966 denotes retina
T8354 7843-7860 _FRAGMENT denotes Inner segments of
T8355 7868-7882 GO:0001917 denotes photoreceptors
T8356 7861-7864 PR_EXT:000005904 denotes Crx
T8357 7864-7865 SO_EXT:sequence_nullness_or_absence denotes -
T8358 7866-7867 SO_EXT:sequence_nullness_or_absence denotes -
T8359 7868-7882 CL:0000210 denotes photoreceptors
T8360 7900-7912 GO:0005739 denotes mitochondria
T8361 7914-7915 GO:0005739 denotes m
T8362 7942-7945 PR_EXT:000005904 denotes Crx
T8363 7945-7946 SO_EXT:normal_or_wild_type_or_present denotes +
T8364 7947-7948 SO_EXT:normal_or_wild_type_or_present denotes +
T8365 7966-7975 CHEBI_EXT:26130 denotes pigmented
T8366 7976-7986 UBERON:0000483 denotes epithelium
T8367 7988-7990 GO:0001917 denotes is
T8368 7992-8006 GO:0001917 denotes inner segments
T8369 8008-8011 UBERON:0001789 denotes onl
T8370 8013-8032 UBERON:0001789 denotes outer nuclear layer
T8371 8019-8026 GO:0005634 denotes nuclear
T8520 8953-8961 CHEBI:10545 denotes electron
T8521 8976-8979 PR_EXT:000005904 denotes Crx
T8522 8979-8980 SO_EXT:sequence_nullness_or_absence denotes -
T8523 8981-8982 SO_EXT:sequence_nullness_or_absence denotes -
T8524 8983-8989 UBERON:0000966 denotes retina
T8525 9021-9029 CHEBI:10545 denotes electron
T8526 9044-9047 PR_EXT:000005904 denotes Crx
T8527 9047-9048 SO_EXT:sequence_nullness_or_absence denotes -
T8528 9049-9050 SO_EXT:sequence_nullness_or_absence denotes -
T8529 9065-9078 GO:0001750 denotes outer segment
T8530 9065-9084 UBERON:0003926 denotes outer segment layer
T8531 9102-9114 GO:0042384 denotes ciliogenesis
T8532 9122-9135 CL:0000210 denotes photoreceptor
T8533 9122-9144 _FRAGMENT denotes photoreceptor layer of
T8534 9152-9158 UBERON:0001787 denotes retina
T8535 9145-9148 PR_EXT:000005904 denotes Crx
T8536 9148-9149 SO_EXT:sequence_nullness_or_absence denotes -
T8537 9150-9151 SO_EXT:sequence_nullness_or_absence denotes -
T8538 9160-9186 GO:0032391 denotes Nonmotile connecting cilia
T8539 9257-9274 GO:0032391 denotes Connecting cilium
T8540 9310-9320 GO:0005874 denotes microtuble
T8541 9337-9343 GO:0005929 denotes cilium
T8542 9350-9356 GO:0005929 denotes cilium
T8543 9393-9397 CL_GO_EXT:cell denotes cell
T8544 9393-9405 GO:0005634 denotes cell nucleus
T8545 9407-9408 GO:0005634 denotes n
T8546 9420-9428 GO:0030263 denotes pyknotic
T8547 9456-9462 GO:0031012 denotes matrix
T8548 9464-9466 GO:0031012 denotes mx
T8549 9536-9555 GO:0031988 denotes membranous vesicles
T8550 9581-9594 CL:0000210 denotes photoreceptor
T8551 9620-9628 GO_EXT:biological_release denotes released
T8552 9634-9648 GO:0001917 denotes inner segments
T8553 9674-9701 GO:0032391 denotes Nonmotile connecting cilium
T8554 9727-9730 PR_EXT:000005904 denotes Crx
T8555 9730-9731 SO_EXT:sequence_nullness_or_absence denotes -
T8556 9732-9733 SO_EXT:sequence_nullness_or_absence denotes -
T8557 9734-9747 CL:0000210 denotes photoreceptor
T8558 9798-9809 GO:0005874 denotes microtubule
T8559 9852-9860 CHEBI:10545 denotes electron
T8560 9881-9900 GO:0031988 denotes membranous vesicles
T8561 9937-9951 GO:0001917 denotes inner segments
T8562 9955-9958 PR_EXT:000005904 denotes Crx
T8563 9958-9959 SO_EXT:sequence_nullness_or_absence denotes -
T8564 9960-9961 SO_EXT:sequence_nullness_or_absence denotes -
T8565 9962-9976 CL:0000210 denotes photoreceptors
T8566 9998-10012 GO:0001917 denotes inner segments
T8567 10029-10036 UBERON:0001773 denotes scleral
T8568 10051-10060 CHEBI_EXT:26130 denotes pigmented
T8569 10061-10071 UBERON:0000483 denotes epithelium
T8875 12753-12766 GO:0001750 denotes Outer segment
T8876 12767-12780 GO:0009653 denotes morphogenesis
T8877 12784-12787 PR_EXT:000005904 denotes Crx
T8878 12787-12788 SO_EXT:sequence_nullness_or_absence denotes -
T8879 12789-12790 SO_EXT:sequence_nullness_or_absence denotes -
T8880 12791-12805 CL:0000210 denotes photoreceptors
T8881 12816-12824 CHEBI:10545 denotes electron
T8882 12850-12864 CL:0000210 denotes photoreceptors
T8883 12881-12888 UBERON:0001773 denotes scleral
T8884 12903-12912 CHEBI_EXT:26130 denotes pigmented
T8885 12913-12923 UBERON:0000483 denotes epithelium
T8886 12956-12959 PR_EXT:000005904 denotes Crx
T8887 12959-12960 SO_EXT:normal_or_wild_type_or_present denotes +
T8888 12961-12962 SO_EXT:normal_or_wild_type_or_present denotes +
T8889 12981-12984 PR_EXT:000005904 denotes Crx
T8890 12984-12985 SO_EXT:sequence_nullness_or_absence denotes -
T8891 12986-12987 SO_EXT:sequence_nullness_or_absence denotes -
T8892 13014-13017 PR_EXT:000005904 denotes Crx
T8893 13017-13018 SO_EXT:normal_or_wild_type_or_present denotes +
T8894 13019-13020 SO_EXT:normal_or_wild_type_or_present denotes +
T8895 13021-13027 UBERON:0000966 denotes retina
T8896 13038-13054 GO:0032391 denotes connecting cilia
T8897 13059-13061 GO:0032391 denotes cc
T8898 13099-13113 GO:0001750 denotes outer segments
T8899 13128-13131 PR_EXT:000005904 denotes Crx
T8900 13131-13132 SO_EXT:normal_or_wild_type_or_present denotes +
T8901 13133-13134 SO_EXT:normal_or_wild_type_or_present denotes +
T8902 13135-13148 GO:0001750 denotes outer segment
T8903 13179-13193 GO:0001750 denotes outer segments
T8904 13227-13229 GO:0001750 denotes os
T8905 13255-13257 GO:0001750 denotes os
T8906 13263-13266 PR_EXT:000005904 denotes Crx
T8907 13266-13267 SO_EXT:sequence_nullness_or_absence denotes -
T8908 13268-13269 SO_EXT:sequence_nullness_or_absence denotes -
T8909 13270-13284 CL:0000210 denotes photoreceptors
T8910 13290-13306 GO:0032391 denotes connecting cilia
T8911 13346-13362 GO:0032391 denotes connecting cilia
T8912 13411-13424 GO:0001750 denotes outer segment
T8913 13452-13469 GO:0032391 denotes connecting cilium
T8914 13480-13482 GO:0032391 denotes cc
T8915 13516-13519 PR_EXT:000005904 denotes Crx
T8916 13519-13520 SO_EXT:normal_or_wild_type_or_present denotes +
T8917 13521-13522 SO_EXT:normal_or_wild_type_or_present denotes +
T8918 13573-13589 GO:0032391 denotes connecting cilia
T8919 13603-13606 PR_EXT:000005904 denotes Crx
T8920 13606-13607 SO_EXT:sequence_nullness_or_absence denotes -
T8921 13608-13609 SO_EXT:sequence_nullness_or_absence denotes -
T8922 13614-13616 GO:0032391 denotes cc
T9180 13661-13669 CHEBI:10545 denotes electron
T9181 13685-13688 PR_EXT:000005904 denotes Crx
T9182 13688-13689 SO_EXT:sequence_nullness_or_absence denotes -
T9183 13690-13691 SO_EXT:sequence_nullness_or_absence denotes -
T9184 13692-13706 CL:0000210 denotes photoreceptors
T9185 13714-13727 CL:0000210 denotes photoreceptor
T9186 13714-13733 UBERON:0001787 denotes photoreceptor layer
T9187 13745-13758 CL:0000210 denotes Photoreceptor
T9188 13745-13767 _FRAGMENT denotes Photoreceptor layer of
T9189 13775-13781 UBERON:0001787 denotes retina
T9190 13768-13771 PR_EXT:000005904 denotes Crx
T9191 13771-13772 SO_EXT:normal_or_wild_type_or_present denotes +
T9192 13773-13774 SO_EXT:normal_or_wild_type_or_present denotes +
T9193 13804-13817 GO:0001750 denotes outer segment
T9194 13851-13864 CL:0000210 denotes photoreceptor
T9195 13851-13881 GO:0032391 denotes photoreceptor connecting cilia
T9196 13883-13885 GO:0032391 denotes cc
T9197 13892-13895 PR_EXT:000005904 denotes Crx
T9198 13895-13896 SO_EXT:sequence_nullness_or_absence denotes -
T9199 13897-13898 SO_EXT:sequence_nullness_or_absence denotes -
T9200 13899-13913 CL:0000210 denotes photoreceptors
T9201 13924-13940 GO:0032391 denotes connecting cilia
T9202 13942-13944 GO:0032391 denotes cc
T9203 13984-13997 GO:0001750 denotes outer segment
T9304 14645-14653 CHEBI:10545 denotes electron
T9305 14668-14678 PR_EXT:peripherin denotes peripherin
T9306 14678-14679 SO_EXT:sequence_nullness_or_absence denotes -
T9307 14680-14681 SO_EXT:sequence_nullness_or_absence denotes -
T9308 14690-14699 PR_EXT:000001245 denotes rhodopsin
T9309 14699-14700 SO_EXT:sequence_nullness_or_absence denotes -
T9310 14701-14702 SO_EXT:sequence_nullness_or_absence denotes -
T9311 14707-14721 CL:0000210 denotes photoreceptors
T9312 14746-14753 UBERON:0001773 denotes scleral
T9313 14768-14777 CHEBI_EXT:26130 denotes pigmented
T9314 14778-14788 UBERON:0000483 denotes epithelium
T9315 14798-14800 GO:0032391 denotes cc
T9316 14802-14819 GO:0032391 denotes connecting cilium
T9317 14821-14823 GO:0001917 denotes is
T9318 14825-14838 GO:0001917 denotes inner segment
T9420 16514-16522 CHEBI:10545 denotes electron
T9421 16542-16563 UBERON:0001790 denotes outer plexiform layer
T9422 16567-16570 PR_EXT:000005904 denotes Crx
T9423 16570-16571 SO_EXT:sequence_nullness_or_absence denotes -
T9424 16572-16573 SO_EXT:sequence_nullness_or_absence denotes -
T9425 16574-16581 UBERON:0000966 denotes retinas
T9426 16590-16593 PR_EXT:000005904 denotes Crx
T9427 16593-16594 SO_EXT:normal_or_wild_type_or_present denotes +
T9428 16595-16596 SO_EXT:normal_or_wild_type_or_present denotes +
T9429 16597-16603 UBERON:0000966 denotes retina
T9430 16625-16628 CL:0000604 denotes rod
T9431 16625-16638 GO:0044317 denotes rod spherules
T9432 16691-16700 GO:0044317 denotes spherules
T9433 16754-16761 GO:0045202 denotes synapse
T9434 16787-16791 CL:0000573 denotes Cone
T9435 16792-16801 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9436 16819-16827 GO:0044316 denotes pedicles
T9437 16859-16867 GO:0045202 denotes synapses
T9438 16907-16916 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9439 16951-16954 PR_EXT:000005904 denotes Crx
T9440 16954-16955 SO_EXT:normal_or_wild_type_or_present denotes +
T9441 16956-16957 SO_EXT:normal_or_wild_type_or_present denotes +
T9442 17006-17027 _FRAGMENT denotes outer plexiform layer
T9443 17034-17036 _FRAGMENT denotes of
T9444 17044-17051 UBERON:0001790 denotes retinas
T9445 17029-17032 _FRAGMENT denotes OPL
T9446 17037-17040 PR_EXT:000005904 denotes Crx
T9447 17040-17041 SO_EXT:sequence_nullness_or_absence denotes -
T9448 17042-17043 SO_EXT:sequence_nullness_or_absence denotes -
T9449 17053-17066 CL:0000210 denotes photoreceptor
T9450 17067-17076 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9451 17135-17143 GO:0044316 denotes pedicles
T9452 17148-17157 GO:0044317 denotes spherules
T9453 17185-17194 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9454 17286-17304 GO:0044456 denotes synapse components
T9455 17311-17320 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9456 17416-17424 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T9457 17469-17477 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminal
T9458 17510-17513 UBERON:0001790 denotes opl
T9459 17515-17536 UBERON:0001790 denotes outer plexiform layer
T9756 17579-17587 CHEBI:10545 denotes electron
T9757 17607-17628 UBERON:0001790 denotes outer plexiform layer
T9758 17632-17635 PR_EXT:000005904 denotes Crx
T9759 17635-17636 SO_EXT:sequence_nullness_or_absence denotes -
T9760 17637-17638 SO_EXT:sequence_nullness_or_absence denotes -
T9761 17639-17646 UBERON:0000966 denotes retinas
T9762 17659-17662 PR_EXT:000005904 denotes Crx
T9763 17662-17663 SO_EXT:normal_or_wild_type_or_present denotes +
T9764 17664-17665 SO_EXT:normal_or_wild_type_or_present denotes +
T9765 17666-17669 CL:0000604 denotes rod
T9766 17666-17679 GO:0044317 denotes rod spherules
T9767 17712-17719 GO:0045202 denotes synapse
T9768 17749-17757 GO:0044317 denotes spherule
T9769 17800-17803 PR_EXT:000005904 denotes Crx
T9770 17803-17804 SO_EXT:normal_or_wild_type_or_present denotes +
T9771 17805-17806 SO_EXT:normal_or_wild_type_or_present denotes +
T9772 17807-17810 CL:0000604 denotes rod
T9773 17811-17820 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9774 17858-17859 CL:0000604 denotes r
T9775 17866-17875 GO:0042995 denotes processes
T9776 17882-17898 CL:0000745 denotes horizontal cells
T9777 17893-17898 CL_GO_EXT:cell denotes cells
T9778 17900-17901 CL:0000745 denotes h
T9779 17918-17921 CL:0000604 denotes rod
T9780 17947-17954 GO:0042995 denotes process
T9781 17960-17972 GO:0098794 denotes postsynaptic
T9782 17981-17989 GO:0030425 denotes dendrite
T9783 18024-18033 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes Terminals
T9784 18051-18068 GO:0008021 denotes synaptic vesicles
T9785 18074-18088 GO:0030135 denotes coated vesicle
T9786 18110-18114 CL_GO_EXT:cell denotes cell
T9787 18110-18123 GO:0005886 denotes cell membrane
T9788 18157-18163 _FRAGMENT denotes OPL of
T9789 18171-18178 UBERON:0001790 denotes retinas
T9790 18164-18167 PR_EXT:000005904 denotes Crx
T9791 18167-18168 SO_EXT:sequence_nullness_or_absence denotes -
T9792 18169-18170 SO_EXT:sequence_nullness_or_absence denotes -
T9793 18180-18193 CL:0000210 denotes photoreceptor
T9794 18194-18203 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9795 18243-18252 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9796 18264-18281 GO:0008021 denotes synaptic vesicles
T9797 18375-18393 GO:0044456 denotes synapse components
T9798 18416-18425 GO:0044317 denotes spherules
T9799 18430-18438 GO:0044316 denotes pedicles
T9800 18472-18481 GO_UBERON_EXT:nerve_ending_or_neuron_projection_terminus denotes terminals
T9801 18598-18615 GO:0097060 denotes synaptic membrane
T9802 18687-18694 GO:0005634 denotes nuclear
T9803 18707-18708 CL:0000745 denotes H
T9804 18710-18725 CL:0000745 denotes horizontal cell
T9805 18721-18725 CL_GO_EXT:cell denotes cell
T9806 18727-18728 CL:0000103 denotes B
T9807 18730-18742 CL:0000103 denotes bipolar cell
T9808 18738-18742 CL_GO_EXT:cell denotes cell
T9809 18744-18745 GO:0005634 denotes N
T9810 18747-18754 GO:0005634 denotes nucleus
T7646 31559-31563 NCBITaxon:10088 denotes Mice
T7647 31564-31567 PR_EXT:000005904 denotes Crx
T7648 31567-31568 SO_EXT:sequence_nullness_or_absence denotes -
T7649 31569-31570 SO_EXT:sequence_nullness_or_absence denotes -
T7650 31571-31575 NCBITaxon:10088 denotes mice
T7651 31619-31627 PR_EXT:000001245 denotes Rhodosin
T7652 31628-31632 SO_EXT:sequence_nullness denotes null
T7653 31633-31637 NCBITaxon:10088 denotes mice
T7654 31701-31704 PR_EXT:000013290 denotes Rds
T7655 31705-31709 NCBITaxon:10088 denotes mice
T8230 7515-7523 CHEBI:10545 denotes electron
T8231 7548-7554 UBERON:0000966 denotes retina
T8232 7569-7572 PR_EXT:000005904 denotes Crx
T8233 7572-7573 SO_EXT:normal_or_wild_type_or_present denotes +
T8234 7574-7575 SO_EXT:normal_or_wild_type_or_present denotes +
T8235 7584-7587 PR_EXT:000005904 denotes Crx
T8236 7587-7588 SO_EXT:sequence_nullness_or_absence denotes -
T8237 7589-7590 SO_EXT:sequence_nullness_or_absence denotes -
T8238 7591-7598 UBERON:0000966 denotes retinas
T8239 7604-7613 CHEBI_EXT:26130 denotes pigmented
T8240 7614-7624 UBERON:0000483 denotes epithelium
T8241 7626-7628 GO:0001750 denotes os
T8242 7630-7644 GO:0001750 denotes outer segments
T8243 7646-7648 GO:0001917 denotes is
T8244 7650-7664 GO:0001917 denotes inner segments
T2135 6459-6462 PR_EXT:000005904 denotes Crx
T2136 6462-6463 SO_EXT:sequence_nullness_or_absence denotes -
T2137 6464-6465 SO_EXT:sequence_nullness_or_absence denotes -
T2138 6466-6470 NCBITaxon:10088 denotes mice
T2139 6522-6526 NCBITaxon:10088 denotes mice
T2140 6555-6558 PR_EXT:000005904 denotes Crx
T2141 6558-6559 SO_EXT:sequence_nullness_or_absence denotes -
T2142 6560-6561 SO_EXT:sequence_nullness_or_absence denotes -
T2143 6579-6586 SO_EXT:sequence_deletion_process denotes deleted
T2144 6608-6611 PR_EXT:000005904 denotes Crx
T2145 6611-6612 SO_EXT:sequence_nullness_or_absence denotes -
T2146 6613-6614 SO_EXT:sequence_nullness_or_absence denotes -
T2147 6615-6619 NCBITaxon:10088 denotes mice
T2148 6714-6717 PR_EXT:000005904 denotes Crx
T2149 6721-6734 CL:0000210 denotes photoreceptor
T2150 6721-6748 GO:0008594 denotes photoreceptor morphogenesis
T2151 6760-6767 UBERON:0000966 denotes retinae
T2152 6773-6776 PR_EXT:000005904 denotes Crx
T2153 6776-6777 SO_EXT:sequence_nullness_or_absence denotes -
T2154 6778-6779 SO_EXT:sequence_nullness_or_absence denotes -
T2155 6780-6784 NCBITaxon:10088 denotes mice
T2156 6818-6826 CHEBI:10545 denotes electron
T2198 8087-8089 CHEBI_EXT:26130 denotes te
T2199 8089-8099 GO:0001917 denotes r segments
T2200 8100-8103 UBERON:0001789 denotes are
T2201 8100-8102 GO:0005634 denotes ar
T2202 8116-8144 GO:0032391 denotes non-motile connecting cilium
T2203 8197-8208 GO:0005874 denotes microtubule
T2204 8259-8262 PR_EXT:000005904 denotes Crx
T2205 8262-8263 SO_EXT:sequence_nullness_or_absence denotes -
T2206 8264-8265 SO_EXT:sequence_nullness_or_absence denotes -
T2207 8266-8273 UBERON:0000966 denotes retinas
T2208 8302-8318 GO:0032391 denotes connecting cilia
T2209 8364-8380 GO:0032391 denotes connecting cilia
T2210 8428-8439 GO:0005874 denotes microtubule
T2211 8481-8498 GO:0032391 denotes connecting cilium
T2212 8699-8712 GO:0001917 denotes inner segment
T2213 8724-8736 GO:0042384 denotes ciliogenesis
T2214 8763-8766 PR_EXT:000005904 denotes Crx
T2215 8766-8767 SO_EXT:sequence_nullness_or_absence denotes -
T2216 8768-8769 SO_EXT:sequence_nullness_or_absence denotes -
T2217 8770-8784 CL:0000210 denotes photoreceptors
T2218 8798-8801 PR_EXT:000005904 denotes Crx
T2219 8801-8802 SO_EXT:sequence_nullness_or_absence denotes -
T2220 8803-8804 SO_EXT:sequence_nullness_or_absence denotes -
T2221 8805-8812 UBERON:0000966 denotes retinas
T2222 8817-8845 UBERON:0001782 denotes retinal pigmented epithelium
T2223 8825-8834 CHEBI_EXT:26130 denotes pigmented
T2224 10106-10108 GO:0030263 denotes ti
T2225 10111-10112 GO:0031012 denotes t
T2226 10118-10119 GO:0031988 denotes c
T2227 10121-10122 CL:0000210 denotes p
T2228 10123-10124 GO:0005874 denotes e
T2229 10128-10131 GO:0031988 denotes bse
T2230 10132-10134 CL:0000210 denotes ce
T2231 10139-10152 GO:0001750 denotes uter segments
T2232 10154-10157 PR_EXT:000005904 denotes Crx
T2233 10157-10158 SO_EXT:sequence_nullness_or_absence denotes -
T2321 14048-14049 GO:0001750 denotes n
T2322 14050-14051 CHEBI:10545 denotes l
T2323 14055-14056 GO:0001750 denotes t
T2324 14065-14066 UBERON:0001787 denotes l
T2325 14066-14067 CL:0000210 denotes o
T2326 14066-14067 _FRAGMENT denotes o
T2327 14087-14090 PR_EXT:000005904 denotes Crx
T2328 14090-14091 SO_EXT:sequence_nullness_or_absence denotes -
T2329 14092-14093 SO_EXT:sequence_nullness_or_absence denotes -
T2330 14094-14108 CL:0000210 denotes photoreceptors
T2331 14125-14134 PR_EXT:000001245 denotes rhodopsin
T2332 14134-14135 SO_EXT:sequence_nullness_or_absence denotes -
T2333 14136-14137 SO_EXT:sequence_nullness_or_absence denotes -
T2334 14142-14152 PR_EXT:peripherin denotes peripherin
T2335 14152-14153 SO_EXT:sequence_nullness_or_absence denotes -
T2336 14154-14155 SO_EXT:sequence_nullness_or_absence denotes -
T2337 14156-14170 CL:0000210 denotes photoreceptors
T2338 14172-14181 PR_EXT:000001245 denotes Rhodopsin
T2339 14186-14196 PR_EXT:peripherin denotes peripherin
T2340 14205-14218 CL:0000210 denotes photoreceptor
R2108 T3602 T3601 _lexicallyChainedTo cells,processes from
R2109 T3613 T3612 _lexicallyChainedTo cell,horizontal
R2110 T3624 T3623 _lexicallyChainedTo retinas,OPL of
R2521 T4507 T4506 _lexicallyChainedTo membranes,breakdown of
R2522 T4581 T4580 _lexicallyChainedTo R6,photoreceptors
R2523 T4589 T4588 _lexicallyChainedTo photoreceptors,R1
R3491 T6147 T6146 _lexicallyChainedTo retinas,outer plexiform layer of
R4245 T7134 T7133 _lexicallyChainedTo tissue,formation of
R5117 T8355 T8354 _lexicallyChainedTo photoreceptors,Inner segments of
R5180 T8534 T8533 _lexicallyChainedTo retina,photoreceptor layer of
R5615 T9189 T9188 _lexicallyChainedTo retina,Photoreceptor layer of
R5740 T9443 T9442 _lexicallyChainedTo of,outer plexiform layer
R5741 T9443 T9445 _lexicallyChainedTo of,OPL
R5742 T9444 T9443 _lexicallyChainedTo retinas,of
R5937 T9789 T9788 _lexicallyChainedTo retinas,OPL of
R3 T79 T78 _lexicallyChainedTo retina,development of
R4 T84 T83 _lexicallyChainedTo of photoreceptor cells,development
R212 T643 T642 _lexicallyChainedTo photoreceptors,development of
R213 T690 T689 _lexicallyChainedTo of,differentiation
R214 T691 T690 _lexicallyChainedTo cells,of
R215 T752 T751 _lexicallyChainedTo cells,processes of
R216 T754 T753 _lexicallyChainedTo cells,horizontal
R217 T773 T772 _lexicallyChainedTo bipolar cells,on
R218 T780 T779 _lexicallyChainedTo bipolar cells,off
R219 T785 T784 _lexicallyChainedTo synapses,formation of
R1143 T2252 T2251 _lexicallyChainedTo photoreceptors,morphogenesis of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T36 0-14 GO:0007416 denotes Synaptogenesis
T37 19-32 GO:0001750 denotes outer segment
T38 64-77 UBERON:0003902 denotes neural retina
T39 81-84 PR:000005904 denotes Crx
T40 92-96 NCBITaxon:10088 denotes mice
T41 166-177 NCBITaxon:1 denotes individuals
T42 208-213 GO:0007567 denotes birth
T43 250-264 _FRAGMENT denotes development of
T44 276-282 GO:0060041 denotes retina
T45 269-282 UBERON:0003902 denotes neural retina
T46 297-302 SO:0000704 denotes genes
T47 319-330 _FRAGMENT denotes development
T48 347-369 GO:0042461 denotes of photoreceptor cells
T49 350-369 CL:0000210 denotes photoreceptor cells
T50 462-475 CL:0000210 denotes photoreceptor
T51 498-501 PR:000005904 denotes Crx
T52 514-517 PR:000005904 denotes Crx
T53 535-539 NCBITaxon:10088 denotes mice
T54 613-616 PR:000005904 denotes Crx
T55 690-696 UBERON:0000966 denotes retina
T56 700-703 PR:000005904 denotes Crx
T57 711-715 NCBITaxon:10088 denotes mice
T58 731-744 GO:0001750 denotes Outer segment
T59 745-758 GO:0009653 denotes morphogenesis
T60 850-867 GO:0007602 denotes phototransduction
T61 888-891 PR:000005904 denotes Crx
T62 895-909 CL:0000210 denotes photoreceptors
T63 941-949 GO:0045202 denotes synaptic
T64 965-986 UBERON:0001790 denotes outer plexiform layer
T65 1031-1045 GO:0007416 denotes synaptogenesis
T66 1059-1065 NCBITaxon:33208 denotes animal
T67 1124-1128 SO:0000704 denotes gene
T68 1158-1171 CL:0000210 denotes photoreceptor
T69 1158-1183 GO:0042461 denotes photoreceptor development
T479 1256-1275 CL:0000210 denotes Photoreceptor cells
T480 1299-1305 GO:0007601 denotes vision
T481 1377-1392 CL:0000101 denotes sensory neurons
T482 1421-1430 NCBITaxon:1 denotes organisms
T483 1460-1466 NCBITaxon:9606 denotes humans
T484 1468-1475 SO:0000704 denotes genetic
T485 1492-1495 UBERON:0000970 denotes eye
T486 1558-1572 CL:0000210 denotes photoreceptors
T487 1597-1611 CL:0000210 denotes Photoreceptors
T488 1700-1717 GO:0007602 denotes phototransduction
T489 1736-1750 _FRAGMENT denotes development of
T490 1762-1776 GO:0042461 denotes photoreceptors
T491 1751-1761 NCBITaxon:7742 denotes vertebrate
T492 1762-1776 CL:0000210 denotes photoreceptors
T493 1886-1896 GO:0065007 denotes regulating
T494 1897-1910 CL:0000210 denotes photoreceptor
T495 1897-1922 GO:0042461 denotes photoreceptor development
T496 1964-1967 PR:000005904 denotes Crx
T497 1969-1973 CL:0000573 denotes cone
T498 1969-1986 PR:000005904 denotes cone-rod homeobox
T499 1974-1977 CL:0000604 denotes rod
T500 2014-2018 SO:0000704 denotes gene
T501 2019-2028 GO:0010467 denotes expressed
T502 2046-2060 CL:0000210 denotes photoreceptors
T503 2109-2114 UBERON:0007023 denotes adult
T504 2127-2130 PR:000005904 denotes Crx
T505 2131-2135 SO:0000704 denotes gene
T506 2131-2146 GO:0010467 denotes gene expression
T507 2176-2180 PR:000012086 denotes Otx2
T508 2234-2243 GO:0010467 denotes expressed
T509 2253-2272 CL:0000210 denotes photoreceptor cells
T510 2281-2299 CL:0000604 denotes rod photoreceptors
T511 2301-2304 PR:000005904 denotes Crx
T512 2337-2340 PR:000011432 denotes Nrl
T513 2398-2408 GO:0010467 denotes expression
T514 2416-2422 UBERON:0000966 denotes retina
T515 2426-2444 CL:0000604 denotes rod photoreceptors
T516 2455-2468 CL:0000210 denotes photoreceptor
T517 2478-2483 SO:0000704 denotes genes
T518 2498-2501 PR:000005904 denotes Crx
T519 2502-2518 SO:0000409 denotes binding elements
T520 2528-2538 GO:0065007 denotes regulatory
T521 2528-2546 SO:0005836 denotes regulatory regions
T522 2563-2572 PR:000001245 denotes rhodopsin
T523 2610-2613 PR:000005904 denotes Crx
T524 2648-2653 NCBITaxon:9606 denotes human
T525 2697-2701 CL:0000573 denotes cone
T526 2702-2705 CL:0000604 denotes rod
T527 2794-2797 PR:000005904 denotes Crx
T528 2846-2861 _FRAGMENT denotes differentiation
T529 2879-2881 _FRAGMENT denotes of
T530 2896-2901 GO:0030154 denotes cells
T531 2882-2901 CL:0000210 denotes photoreceptor cells
T532 2932-2939 SO:0000704 denotes genetic
T533 2951-2965 CL:0000210 denotes photoreceptors
T534 3061-3067 GO:0007601 denotes vision
T535 3073-3078 GO:0007567 denotes birth
T536 3093-3100 UBERON:0000966 denotes retinal
T537 3110-3115 SO:0000704 denotes genes
T538 3125-3128 PR:000005904 denotes Crx
T539 3180-3186 PR:000008353 denotes GUCY2D
T540 3193-3198 PR:000014179 denotes RPE65
T541 3205-3211 PR:000003876 denotes AIPL-1
T542 3218-3223 PR:000005848 denotes CRB-1
T543 3234-3242 PR:000014182 denotes RPGRIP-1
T544 3295-3318 SO:0000018 denotes genetically linked loci
T545 3325-3330 SO:0000704 denotes genes
T546 3362-3365 PR:000005904 denotes Crx
T547 3491-3494 PR:000005904 denotes Crx
T548 3565-3571 SO:0001023 denotes allele
T549 3811-3816 NCBITaxon:9606 denotes human
T550 3885-3891 UBERON:0010230 denotes globes
T551 3895-3901 UBERON:0007023 denotes adults
T552 3922-3928 UBERON:0000479 denotes tissue
T553 4010-4013 UBERON:0000970 denotes eye
T554 4046-4052 NCBITaxon:33208 denotes Animal
T555 4221-4232 SO:0000704 denotes genetically
T556 4268-4273 NCBITaxon:10088 denotes mouse
T557 4350-4363 CL:0000210 denotes photoreceptor
T558 4350-4375 GO:0042461 denotes photoreceptor development
T559 4444-4463 CL:0000210 denotes photoreceptor cells
T560 4507-4515 CL:0000540 denotes neuronal
T561 4533-4552 CL:0000210 denotes Photoreceptor cells
T562 4584-4588 GO:0045177 denotes apex
T563 4596-4603 CL:0000540 denotes neurons
T564 4611-4621 GO:0016020 denotes membranous
T565 4622-4635 GO:0001750 denotes outer segment
T566 4677-4702 GO:0007602 denotes phototransduction cascade
T567 4734-4743 PR:000001245 denotes rhodopsin
T568 4825-4839 GO:0001750 denotes outer segments
T569 4865-4879 CL:0000210 denotes photoreceptors
T570 4895-4903 GO:0045202 denotes synaptic
T571 4939-4951 _FRAGMENT denotes processes of
T572 4975-4980 GO:0042995 denotes cells
T573 4952-4962 _FRAGMENT denotes horizontal
T574 4975-4980 CL:0000745 denotes cells
T575 4967-4980 CL:0000103 denotes bipolar cells
T576 4990-4993 CL:0000604 denotes Rod
T577 4990-5003 GO:0044317 denotes Rod spherules
T578 5030-5037 GO:0045202 denotes synapse
T587 5193-5206 GO:0044316 denotes Cone pedicles
T588 5225-5233 GO:0045202 denotes synapses
T589 5243-5252 GO:0030425 denotes dendrites
T590 5256-5258 _FRAGMENT denotes on
T591 5264-5277 CL:0000749 denotes bipolar cells
T592 5259-5263 CL:0000573 denotes cone
T593 5282-5298 CL:0000745 denotes horizontal cells
T594 5328-5337 GO:0030425 denotes dendrites
T595 5341-5344 _FRAGMENT denotes off
T596 5350-5363 CL:0000750 denotes bipolar cells
T597 5345-5349 CL:0000573 denotes cone
T598 5377-5387 GO:0065007 denotes regulating
T599 5392-5404 _FRAGMENT denotes formation of
T600 5423-5431 GO:0007416 denotes synapses
T601 5409-5422 CL:0000210 denotes photoreceptor
T602 5423-5431 GO:0045202 denotes synapses
T603 5469-5482 CL:0000210 denotes photoreceptor
T604 5483-5491 GO:0045202 denotes synaptic
T605 5501-5505 PR:000017084 denotes HRG4
T606 5528-5531 PR:000005904 denotes Crx
T607 5555-5590 SO:0001679 denotes transcriptional regulatory sequence
T608 5571-5581 GO:0065007 denotes regulatory
T609 5616-5622 NCBITaxon:33208 denotes animal
T610 5665-5672 UBERON:0000966 denotes retinal
T611 5733-5741 CL:0000540 denotes neuronal
T612 5767-5774 GO:0045202 denotes synapse
T613 5767-5784 GO:0007416 denotes synapse formation
T614 5968-5974 UBERON:0000966 denotes retina
T615 5978-5981 PR:000005904 denotes Crx
T616 5985-5989 NCBITaxon:10088 denotes mice
T617 6026-6033 UBERON:0000966 denotes retinas
T618 6069-6072 PR:000005904 denotes Crx
T619 6076-6090 CL:0000210 denotes photoreceptors
T620 6123-6136 GO:0001750 denotes outer segment
T621 6210-6218 GO:0045202 denotes synaptic
T622 6266-6269 PR:000005904 denotes Crx
T623 6273-6286 CL:0000210 denotes photoreceptor
T624 6287-6301 GO:0007416 denotes synaptogenesis
T625 6372-6379 GO:0045202 denotes synapse
T626 6372-6389 GO:0007416 denotes synapse formation
T1970 6436-6449 GO:0001750 denotes outer segment
T1971 6436-6455 UBERON:0003926 denotes outer segment layer
T1972 6459-6462 PR:000005904 denotes Crx
T1973 6466-6470 NCBITaxon:10088 denotes mice
T1974 6522-6526 NCBITaxon:10088 denotes mice
T1975 6555-6558 PR:000005904 denotes Crx
T1976 6608-6611 PR:000005904 denotes Crx
T1977 6615-6619 NCBITaxon:10088 denotes mice
T1978 6714-6717 PR:000005904 denotes Crx
T1979 6721-6734 CL:0000210 denotes photoreceptor
T1980 6721-6748 GO:0008594 denotes photoreceptor morphogenesis
T1981 6760-6767 UBERON:0000966 denotes retinae
T1982 6773-6776 PR:000005904 denotes Crx
T1983 6780-6784 NCBITaxon:10088 denotes mice
T1984 6818-6826 CHEBI:10545 denotes electron
T1985 6846-6851 GO:0007567 denotes natal
T1986 6871-6874 PR:000005904 denotes Crx
T1987 6878-6892 CL:0000210 denotes photoreceptors
T1988 6910-6924 GO:0001750 denotes outer segments
T1989 6942-6945 PR:000005904 denotes Crx
T1990 6949-6956 UBERON:0000966 denotes retinas
T1991 6985-6998 GO:0001750 denotes outer segment
T1992 6985-7004 UBERON:0003926 denotes outer segment layer
T1993 7018-7021 PR:000005904 denotes Crx
T1994 7025-7039 CL:0000210 denotes photoreceptors
T1995 7044-7058 GO:0001917 denotes inner segments
T1996 7091-7104 CL:0000210 denotes photoreceptor
T1997 7125-7128 PR:000005904 denotes Crx
T1998 7145-7159 GO:0001917 denotes inner segments
T1999 7222-7236 GO:0001917 denotes inner segments
T2000 7309-7321 GO:0005739 denotes mitochondria
T2001 7372-7385 GO:0001917 denotes inner segment
T2002 7397-7402 GO:0019835 denotes lysis
T2003 7440-7448 GO:0005773 denotes vacuoles
T2004 7461-7473 GO:0005739 denotes mitochondria
T2005 8053-8054 UBERON:0000483 denotes h
T2006 8054-8055 GO:0001750 denotes o
T2007 8055-8056 GO:0001750 denotes t
T2051 10357-10363 GO:0005634 denotes nuclei
T2052 10434-10440 GO:0005634 denotes nuclei
T2053 10450-10458 GO:0030263 denotes pyknotic
T2054 10510-10525 GO:0000792 denotes heterochromatin
T2055 10545-10559 CL:0000210 denotes photoreceptors
T2056 10628-10642 CL:0000210 denotes photoreceptors
T2090 11794-11808 CL:0000210 denotes photoreceptors
T2091 11836-11852 GO:0032391 denotes connecting cilia
T2092 11861-11875 GO:0001750 denotes outer segments
T2093 11907-11910 PR:000005904 denotes Crx
T2094 11914-11928 CL:0000210 denotes photoreceptors
T2095 11983-12000 GO:0032391 denotes connecting cilium
T2096 12051-12064 GO:0001750 denotes outer segment
T2097 12151-12165 GO:0001750 denotes outer segments
T2098 12192-12195 PR:000005904 denotes Crx
T2099 12261-12264 PR:000005904 denotes Crx
T2100 12268-12282 CL:0000210 denotes photoreceptors
T2101 12299-12315 GO:0032391 denotes connecting cilia
T2102 12366-12369 PR:000005904 denotes Crx
T2103 12373-12387 CL:0000210 denotes photoreceptors
T2104 12581-12594 GO:0001750 denotes outer segment
T2105 12612-12615 PR:000005904 denotes Crx
T2106 12623-12628 NCBITaxon:10088 denotes mouse
T2107 12667-12680 CL:0000210 denotes photoreceptor
T2108 12681-12690 GO:0042995 denotes appendage
T2109 12718-12731 GO:0001750 denotes outer segment
T2110 14048-14049 GO:0001750 denotes n
T2111 14050-14051 CHEBI:10545 denotes l
T2112 14055-14056 GO:0001750 denotes t
T2113 14065-14066 UBERON:0001787 denotes l
T2114 14066-14067 CL:0000210 denotes o
T2115 14066-14067 _FRAGMENT denotes o
T2124 14289-14292 PR:000005904 denotes Crx
T2125 14296-14303 UBERON:0000966 denotes retinae
T2127 14432-14446 GO:0001750 denotes outer segments
T2128 14456-14470 CL:0000210 denotes Photoreceptors
T2129 14493-14497 NCBITaxon:10088 denotes mice
T2130 14523-14530 UBERON:0001773 denotes scleral
T2131 14563-14566 PR:000005904 denotes Crx
T2132 14570-14584 CL:0000210 denotes photoreceptors
T3526 14860-14863 PR:000005904 denotes Crx
T3527 14898-14911 CL:0000210 denotes photoreceptor
T3528 14971-14981 GO:0010467 denotes expression
T3529 15005-15011 SO:0001023 denotes allele
T3530 15015-15018 PR:000005904 denotes Crx
T3531 15033-15037 CL:0000604 denotes rods
T3532 15064-15067 CL:0000604 denotes rod
T3533 15064-15077 GO:0044317 denotes rod spherules
T3534 15085-15106 UBERON:0001790 denotes outer plexiform layer
T3535 15108-15111 UBERON:0001790 denotes OPL
T3536 15117-15131 GO:0001750 denotes outer segments
T3537 15187-15200 CL:0000210 denotes photoreceptor
T3538 15201-15209 GO:0045202 denotes synapses
T3539 15226-15229 PR:000005904 denotes Crx
T3540 15233-15240 UBERON:0000966 denotes retinas
T3541 15245-15248 PR:000005904 denotes Crx
T3542 15252-15259 UBERON:0000966 denotes retinas
T3543 15281-15284 CL:0000604 denotes rod
T3544 15281-15294 GO:0044317 denotes rod spherules
T3545 15326-15334 GO:0044317 denotes sperules
T3546 15431-15438 GO:0045202 denotes synapse
T3547 15503-15517 _FRAGMENT denotes processes from
T3548 15529-15534 GO:0042995 denotes cells
T3549 15518-15534 CL:0000745 denotes horizontal cells
T3550 15571-15579 GO:0045202 denotes synaptic
T3551 15626-15635 GO:0030425 denotes dendrites
T3552 15639-15656 CL:0000751 denotes rod bipolar cells
T3553 15718-15722 CL:0000573 denotes Cone
T3554 15749-15757 GO:0044316 denotes pedicles
T3555 15789-15797 GO:0045202 denotes synapses
T3556 15826-15836 _FRAGMENT denotes horizontal
T3557 15849-15853 CL:0000745 denotes cell
T3558 15841-15853 CL:0000103 denotes bipolar cell
T3559 15849-15863 GO:0042995 denotes cell processes
T3560 15870-15877 GO:0044316 denotes pedicle
T3561 15948-15957 GO:0044317 denotes spherules
T3562 15961-15964 PR:000005904 denotes Crx
T3563 15968-15975 UBERON:0000966 denotes retinas
T3564 16007-16013 _FRAGMENT denotes OPL of
T3565 16021-16028 UBERON:0001790 denotes retinas
T3566 16014-16017 PR:000005904 denotes Crx
T3567 16030-16043 CL:0000210 denotes photoreceptor
T3568 16107-16116 GO:0042995 denotes Processes
T3569 16128-16145 GO:0008021 denotes synaptic vesicles
T3570 16230-16248 GO:0044456 denotes synapse components
T3571 16271-16280 GO:0044317 denotes spherules
T3572 16285-16293 GO:0044316 denotes pedicles
T3573 16420-16435 GO:0005886 denotes plasma membrane
T3574 16460-16467 GO:0005634 denotes nuclear
T3973 18903-18906 PR:000005904 denotes Crx
T3974 18910-18924 CL:0000210 denotes photoreceptors
T3975 18945-18948 PR:000005904 denotes Crx
T3976 19154-19157 PR:000005904 denotes Crx
T3977 19161-19167 UBERON:0000966 denotes retina
T3978 19194-19207 GO:0001750 denotes outer segment
T3979 19208-19221 GO:0009653 denotes morphogenesis
T3980 19284-19297 GO:0001750 denotes outer segment
T3981 19313-19316 PR:000005904 denotes Crx
T3982 19320-19334 CL:0000210 denotes photoreceptors
T3983 19370-19377 GO:0045202 denotes synapse
T3984 19370-19387 GO:0007416 denotes synapse formation
T3985 19427-19441 GO:0007416 denotes synaptogenesis
T3986 19455-19461 NCBITaxon:33208 denotes animal
T4307 19477-19480 PR:000005904 denotes Crx
T4308 19484-19498 CL:0000210 denotes photoreceptors
T4309 19515-19528 GO:0001750 denotes outer segment
T4310 19529-19542 GO:0009653 denotes morphogenesis
T4311 19556-19559 PR:000005904 denotes Crx
T4312 19593-19597 SO:0000704 denotes gene
T4313 19624-19637 GO:0001750 denotes outer segment
T4314 19700-19703 PR:000013290 denotes RDS
T4315 19704-19708 SO:0000704 denotes gene
T4316 19720-19729 PR:000001245 denotes rhodopsin
T4317 19756-19769 GO:0001750 denotes outer segment
T4318 19815-19818 PR:000005904 denotes Crx
T4319 19822-19835 CL:0000210 denotes photoreceptor
T4320 19822-19849 GO:0008594 denotes photoreceptor morphogenesis
T4321 19881-19890 GO:0031982 denotes Vesicular
T4322 19905-19908 PR:000005904 denotes Crx
T4323 19912-19926 CL:0000210 denotes photoreceptors
T4324 19992-19995 PR:000013290 denotes rds
T4325 20010-20015 NCBITaxon:10088 denotes mouse
T4326 20054-20062 GO:0031982 denotes vesicles
T4327 20079-20091 _FRAGMENT denotes breakdown of
T4328 20106-20115 GO:0030397 denotes membranes
T4329 20092-20115 GO:0042622 denotes outer segment membranes
T4330 20156-20170 GO:0001750 denotes outer segments
T4331 20249-20259 GO:0005902 denotes microvilli
T4332 20263-20275 CL:0000636 denotes Müller cells
T4333 20400-20409 PR:000001245 denotes rhodopsin
T4334 20427-20435 GO:0031982 denotes vesicles
T4335 20478-20487 PR:000001245 denotes rhodopsin
T4336 20530-20538 GO:0031982 denotes vesicles
T4337 20562-20576 GO:0001917 denotes inner segments
T4338 20603-20617 CL:0000210 denotes photoreceptors
T4339 20670-20683 GO:0001750 denotes outer segment
T4340 20714-20731 GO:0032391 denotes connecting cilium
T4341 20778-20781 PR:000013290 denotes RDS
T4342 20786-20791 PR:000014157 denotes ROM-1
T4343 20834-20839 PR:000001119 denotes opsin
T4344 20941-20955 GO:0001750 denotes outer segments
T4345 20971-20976 PR:000014157 denotes ROM-1
T4346 20980-20984 NCBITaxon:10088 denotes mice
T4347 21006-21020 GO:0001750 denotes outer segments
T4348 21044-21047 PR:000005904 denotes Crx
T4349 21103-21111 GO:0065007 denotes controls
T4350 21112-21117 SO:0000704 denotes genes
T4351 21187-21200 GO:0001750 denotes outer segment
T4352 21222-21231 PR:000001245 denotes rhodopsin
T4353 21316-21320 SO:0000704 denotes gene
T4354 21316-21331 GO:0010467 denotes gene expression
T4355 21379-21384 SO:0000704 denotes genes
T4356 21411-21421 GO:0010467 denotes expression
T4357 21431-21434 PR:000005904 denotes Crx
T4358 21438-21442 NCBITaxon:10088 denotes mice
T4359 21458-21467 PR:000001245 denotes rhodopsin
T4360 21468-21478 GO:0010467 denotes expression
T4361 21506-21509 PR:000005904 denotes Crx
T4362 21513-21520 NCBITaxon:33208 denotes animals
T4363 21587-21591 NCBITaxon:10088 denotes mice
T4364 21616-21626 GO:0010467 denotes expression
T4365 21640-21649 PR:000001245 denotes rhodopsin
T4366 21658-21661 CL:0000604 denotes rod
T4367 21723-21732 PR:000001245 denotes rhodopsin
T4368 21733-21743 GO:0010467 denotes expression
T4369 21772-21781 PR:000001245 denotes rhodopsin
T4370 21782-21792 GO:0010467 denotes expression
T4371 21843-21853 NCBITaxon:7215 denotes Drosophila
T4372 21858-21868 NCBITaxon:7215 denotes Drosophila
T4373 21870-21879 PR:000001245 denotes rhodopsin
T4374 21881-21886 PR:P06002 denotes ninaE
T4375 21891-21900 GO:0010467 denotes expressed
T4376 21904-21921 CL:0000687 denotes photoreceptors R1
T4377 21904-21918 _FRAGMENT denotes photoreceptors
T4378 21922-21924 CL:0000705 denotes R6
T4379 21929-21934 PR:P06002 denotes ninaE
T4380 21953-21963 GO:0016028 denotes rhabdomere
T4381 21990-22000 NCBITaxon:7742 denotes vertebrate
T4382 22001-22015 GO:0001750 denotes outer segments
T4383 22037-22039 _FRAGMENT denotes R1
T4384 22043-22057 CL:0000687 denotes photoreceptors
T4385 22040-22057 CL:0000705 denotes R6 photoreceptors
T4386 22096-22105 PR:000001245 denotes rhodopsin
T4387 22109-22113 NCBITaxon:10088 denotes mice
T4388 22206-22215 PR:000001245 denotes rhodopsin
T4389 22216-22226 GO:0010467 denotes expression
T4390 22234-22244 GO:0016028 denotes rhabdomere
T4391 22234-22256 GO:0042052 denotes rhabdomere development
T4392 22261-22266 PR:P06002 denotes ninaE
T4393 22272-22277 NCBITaxon:7147 denotes flies
T4394 22281-22286 PR:P06002 denotes ninaE
T4395 22287-22296 SO:0000902 denotes transgene
T4396 22307-22314 GO:0065007 denotes control
T4397 22331-22339 SO:0000167 denotes promoter
T4398 22441-22450 PR:000001245 denotes rhodopsin
T4399 22508-22521 CL:0000210 denotes photoreceptor
T4400 22556-22569 CL:0000210 denotes photoreceptor
T4401 22591-22601 GO:0010467 denotes expression
T4402 22681-22690 PR:000001245 denotes rhodopsin
T4403 22691-22701 GO:0010467 denotes expression
T4404 22774-22784 GO:0016028 denotes rhabdomere
T4405 22774-22798 GO:0061541 denotes rhabdomere morphogenesis
T4406 22851-22854 NCBITaxon:10114 denotes rat
T4407 22863-22872 PR:000001245 denotes rhodopsin
T4408 22942-22946 CL:0000604 denotes rods
T4409 22979-22989 GO:0065007 denotes regulation
T4410 22993-23002 PR:000001245 denotes rhodopsin
T4411 23030-23037 GO:0065007 denotes control
T4412 23078-23087 PR:000001245 denotes rhodopsin
T4413 23111-23114 PR:000005904 denotes Crx
T4414 23122-23132 GO:0065007 denotes regulating
T4415 23133-23146 GO:0001750 denotes outer segment
T4416 23147-23160 GO:0009653 denotes morphogenesis
T4417 23237-23240 PR:000005904 denotes Crx
T4418 23253-23263 NCBITaxon:7215 denotes Drosophila
T4419 23267-23270 PR:P22810 denotes Otd
T4420 23317-23322 SO:0000704 denotes genes
T4421 23332-23335 PR:000005904 denotes Crx
T4422 23379-23385 SO:0001023 denotes allele
T4423 23389-23399 NCBITaxon:7215 denotes Drosophila
T4424 23400-23403 PR:P22810 denotes otd
T4425 23405-23408 PR:P22810 denotes otd
T4426 23413-23426 CL:0000210 denotes photoreceptor
T4427 23413-23440 GO:0008594 denotes photoreceptor morphogenesis
T4428 23500-23505 SO:0000704 denotes genes
T4429 23530-23533 PR:000005904 denotes Crx
T4430 23550-23559 GO:0010467 denotes expressed
T4431 23584-23587 PR:000005904 denotes Crx
T4432 23591-23597 UBERON:0000966 denotes retina
T4433 23607-23616 PR:000001245 denotes rhodopsin
T4434 23687-23701 CL:0000210 denotes photoreceptors
T4435 23711-23721 GO:0010467 denotes expression
T4436 23771-23776 CHEBI:18059 denotes lipid
T4437 23771-23787 GO:0006629 denotes lipid metabolism
T4438 23789-23804 GO:0006457 denotes protein folding
T4439 23929-23942 GO:0001750 denotes outer segment
T4440 23952-23965 GO:0097617 denotes hybridization
T4441 24003-24008 SO:0000704 denotes genes
T4442 24072-24085 GO:0001917 denotes inner segment
T4443 24134-24147 GO:0001750 denotes outer segment
T4444 24190-24195 SO:0000704 denotes genes
T4445 24223-24236 GO:0001750 denotes outer segment
T4446 24274-24288 CL:0000210 denotes photoreceptors
T4447 24328-24340 GO:0042384 denotes ciliogenesis
T4448 24354-24358 SO:0000704 denotes gene
T4449 24360-24364 PR:000005848 denotes CRB1
T4450 24380-24384 SO:0000704 denotes gene
T4451 24385-24389 PR:000005850 denotes CRB3
T4452 24415-24427 GO:0042384 denotes ciliogenesis
T4453 24457-24467 NCBITaxon:7215 denotes Drosophila
T4454 24468-24477 SO:0000853 denotes homologue
T4455 24481-24485 PR:000005848 denotes CRB1
T4456 24487-24493 PR:P10040 denotes Crumbs
T4457 24518-24531 CL:0000210 denotes photoreceptor
T4458 24518-24545 GO:0008594 denotes photoreceptor morphogenesis
T4459 24589-24594 NCBITaxon:10088 denotes mouse
T4460 24605-24609 PR:000005848 denotes CRB1
T4461 24619-24624 NCBITaxon:10088 denotes mouse
T4462 24645-24659 GO:0001750 denotes outer segments
T4463 24711-24724 CL:0000210 denotes photoreceptor
T4464 24742-24756 GO:0007416 denotes synaptogenesis
T4465 24790-24794 PR:000005848 denotes CRB1
T4466 24799-24802 PR:000005904 denotes Crx
T4467 24903-24910 UBERON:0000966 denotes retinal
T4468 24903-24922 GO:0060041 denotes retinal development
T5875 24925-24939 GO:0007416 denotes Synaptogenesis
T5876 24956-24959 PR:000005904 denotes Crx
T5877 24963-24977 CL:0000210 denotes photoreceptors
T5878 24982-24985 PR:000005904 denotes Crx
T5879 24989-24994 NCBITaxon:10088 denotes mouse
T5880 25039-25052 CL:0000210 denotes photoreceptor
T5881 25053-25061 GO:0045202 denotes synapses
T5882 25098-25103 NCBITaxon:10088 denotes mouse
T5883 25136-25149 CL:0000210 denotes photoreceptor
T5884 25189-25203 CL:0000210 denotes photoreceptors
T5885 25238-25247 PR:000001245 denotes rhodopsin
T5886 25249-25252 PR:000001245 denotes Rho
T5887 25258-25275 CHEBI:23447 denotes cyclic nucleotide
T5888 25258-25298 PR:000000696 denotes cyclic nucleotide-gated channel, alpha-3
T5889 25300-25305 PR:000000696 denotes CNGA3
T5890 25323-25327 NCBITaxon:10088 denotes mice
T5891 25329-25332 PR:000001245 denotes Rho
T5892 25337-25342 PR:000000696 denotes CNGA3
T5893 25348-25356 GO:0045202 denotes synapses
T5894 25429-25442 CL:0000210 denotes photoreceptor
T5895 25443-25457 GO:0007416 denotes synaptogenesis
T5896 25486-25499 GO:0001750 denotes outer segment
T5897 25621-25625 NCBITaxon:10088 denotes mice
T5898 25651-25668 GO:0007602 denotes phototransduction
T5899 25689-25693 NCBITaxon:10088 denotes mice
T5900 25727-25740 CL:0000210 denotes photoreceptor
T5901 25741-25748 GO:0045202 denotes synapse
T5902 25775-25791 GO:0044456 denotes synapse elements
T5903 25828-25841 GO:0001750 denotes outer segment
T5904 25906-25919 CL:0000210 denotes photoreceptor
T5905 25965-25982 GO:0007602 denotes phototransduction
T5906 25987-25994 GO:0045202 denotes synapse
T5907 25987-26004 GO:0007416 denotes synapse formation
T5908 26094-26097 PR:000005904 denotes Crx
T5909 26101-26115 CL:0000210 denotes photoreceptors
T5910 26135-26143 GO:0045202 denotes synaptic
T5911 26176-26189 GO:0001750 denotes outer segment
T5912 26235-26238 PR:000005904 denotes Crx
T5913 26255-26268 CL:0000210 denotes photoreceptor
T5914 26269-26276 GO:0045202 denotes synapse
T5915 26269-26286 GO:0007416 denotes synapse formation
T5916 26299-26309 GO:0065007 denotes regulating
T5917 26345-26350 SO:0000704 denotes genes
T5918 26412-26422 GO:0010467 denotes expression
T5919 26433-26445 GO:0098793 denotes pre-synaptic
T5920 26475-26480 PR:000009311 denotes KIF3a
T5921 26482-26485 PR:000015849 denotes SV2
T5922 26491-26504 PR:000015890 denotes synaptophysin
T5923 26565-26568 PR:000005904 denotes Crx
T5924 26584-26590 UBERON:0000479 denotes tissue
T5925 26699-26704 SO:0000704 denotes genes
T5926 26753-26758 SO:0000704 denotes genes
T5927 26845-26850 SO:0000704 denotes genes
T5928 26851-26860 GO:0010467 denotes expressed
T5929 26864-26878 CL:0000210 denotes photoreceptors
T5930 26915-26925 GO:0010467 denotes expression
T5931 26939-26942 PR:000005904 denotes Crx
T5932 26946-26951 NCBITaxon:10088 denotes mouse
T5933 27007-27020 CL:0000210 denotes photoreceptor
T5934 27007-27034 GO:0008594 denotes photoreceptor morphogenesis
T5935 27052-27057 SO:0000704 denotes genes
T5936 27072-27081 GO:0010467 denotes expressed
T5937 27085-27098 CL:0000210 denotes photoreceptor
T5938 27187-27226 PR:000008536 denotes HGF-regulated tyrosine kinase substrate
T5939 27191-27200 GO:0065007 denotes regulated
T5940 27232-27237 PR:000005877 denotes CRIPT
T5941 27251-27266 PR:000015894 denotes synaptotagmin 1
T5942 27324-27328 SO:0000704 denotes gene
T5943 27355-27358 PR:000005904 denotes Crx
T5944 27362-27368 UBERON:0000966 denotes retina
T5945 27372-27376 PR:000017084 denotes HRG4
T5946 27380-27389 SO:0000853 denotes homologue
T5947 27397-27407 NCBITaxon:6239 denotes C. elegans
T5948 27408-27414 PR:Q10658 denotes Unc119
T5949 27415-27419 SO:0000704 denotes gene
T5950 27494-27508 GO:0097470 denotes ribbon synapse
T5951 27630-27635 SO:0000704 denotes genes
T5952 27654-27675 GO:0044430 denotes cytoskeletal elements
T5953 27702-27713 GO:0005874 denotes microtubule
T5954 27702-27734 PR:000010142 denotes microtubule associated protein 4
T5955 27755-27764 PR:000005385 denotes cofilin 1
T5956 27773-27776 PR:000005904 denotes Crx
T5957 27780-27786 UBERON:0000966 denotes retina
T5958 27849-27854 SO:0000704 denotes genes
T5959 27883-27893 GO:0065007 denotes regulating
T5960 27894-27902 GO:0045202 denotes synaptic
T5961 27932-27937 SO:0000704 denotes genes
T5962 28055-28069 GO:0097470 denotes ribbon synapse
T5963 28080-28093 CL:0000210 denotes photoreceptor
T5964 28148-28155 UBERON:0000966 denotes retinal
T5965 28148-28167 GO:0060041 denotes retinal development
T5966 28175-28194 PR:000009655 denotes laminin beta2 chain
T5967 28205-28210 NCBITaxon:10088 denotes mouse
T5968 28257-28261 NCBITaxon:10088 denotes mice
T5969 28270-28289 PR:000009655 denotes laminin beta2 chain
T5970 28300-28304 NCBITaxon:10088 denotes mice
T5971 28324-28337 GO:0001750 denotes outer segment
T5972 28393-28396 PR:000005904 denotes Crx
T5973 28400-28404 NCBITaxon:10088 denotes mice
T5974 28410-28424 GO:0001750 denotes outer segments
T5975 28461-28474 CL:0000210 denotes photoreceptor
T5976 28503-28516 PR:000009655 denotes laminin beta2
T5977 28579-28582 PR:000005904 denotes Crx
T5978 28586-28590 NCBITaxon:10088 denotes mice
T5979 28596-28620 _FRAGMENT denotes outer plexiform layer of
T5980 28641-28648 UBERON:0001790 denotes retinas
T5981 28625-28630 PR:000009655 denotes beta2
T5982 28690-28698 GO:0045202 denotes synapses
T5983 28764-28772 GO:0045202 denotes synaptic
T5984 28838-28847 CHEBI:36357 denotes molecules
T5985 28860-28873 CL:0000210 denotes photoreceptor
T5986 28860-28887 GO:0008594 denotes photoreceptor morphogenesis
T5987 28921-28934 PR:000009655 denotes laminin beta2
T5988 29000-29003 PR:000005904 denotes Crx
T5989 29011-29014 PR:000005904 denotes Crx
T5990 29078-29091 PR:000009655 denotes laminin beta2
T7020 29107-29110 PR:000005904 denotes Crx
T7021 29114-29118 NCBITaxon:10088 denotes mice
T7022 29139-29142 PR:000005904 denotes Crx
T7023 29172-29185 CL:0000210 denotes photoreceptor
T7024 29210-29215 NCBITaxon:9606 denotes human
T7025 29227-29231 CL:0000573 denotes cone
T7026 29232-29235 CL:0000604 denotes rod
T7027 29331-29335 CL:0000573 denotes cone
T7028 29336-29339 CL:0000604 denotes rod
T7029 29388-29392 CL:0000573 denotes cone
T7030 29402-29408 GO:0007601 denotes vision
T7031 29432-29436 UBERON:0000104 denotes life
T7032 29486-29489 CL:0000604 denotes rod
T7033 29499-29505 GO:0007601 denotes vision
T7034 29558-29561 CL:0000604 denotes rod
T7035 29592-29596 CL:0000573 denotes cone
T7036 29606-29612 GO:0007601 denotes vision
T7037 29641-29646 SO:0000704 denotes genes
T7038 29663-29668 NCBITaxon:9606 denotes human
T7039 29669-29676 SO:0000704 denotes genetic
T7040 29704-29713 GO:0010467 denotes expressed
T7041 29753-29767 CL:0000210 denotes photoreceptors
T7042 29789-29802 GO:0001750 denotes outer segment
T7043 29849-29866 GO:0007602 denotes phototransduction
T7044 29870-29883 GO:0001750 denotes outer segment
T7045 29931-29934 CL:0000604 denotes rod
T7046 29944-29949 SO:0000704 denotes genes
T7047 29959-29968 PR:000001245 denotes rhodopsin
T7048 29989-29993 CL:0000573 denotes cone
T7049 30042-30045 PR:000005904 denotes Crx
T7050 30145-30158 CL:0000210 denotes photoreceptor
T7051 30216-30229 CL:0000210 denotes photoreceptor
T7052 30319-30322 PR:000005904 denotes Crx
T7053 30326-30331 NCBITaxon:10088 denotes mouse
T7054 30450-30453 PR:000005904 denotes Crx
T7055 30535-30540 NCBITaxon:9606 denotes human
T7056 30541-30547 UBERON:0000479 denotes tissue
T7057 30571-30576 UBERON:0007023 denotes adult
T7058 30655-30661 NCBITaxon:33208 denotes animal
T7059 30755-30767 _FRAGMENT denotes formation of
T7060 30776-30782 GO:0009888 denotes tissue
T7061 30768-30775 UBERON:0000966 denotes retinal
T7062 30776-30782 UBERON:0000479 denotes tissue
T7063 30807-30812 NCBITaxon:9606 denotes human
T7064 30813-30819 UBERON:0000479 denotes tissue
T7065 30835-30840 NCBITaxon:9606 denotes human
T7066 30849-30855 UBERON:0000966 denotes retina
T7067 30870-30875 PR:000014179 denotes RPE65
T7068 30916-30923 UBERON:0000966 denotes retinae
T7069 31008-31021 CL:0000210 denotes photoreceptor
T7070 31008-31027 UBERON:0001787 denotes photoreceptor layer
T7071 31087-31095 GO:0045202 denotes synaptic
T7072 31106-31113 UBERON:0000966 denotes retinal
T7073 31158-31171 CL:0000210 denotes photoreceptor
T7074 31172-31180 GO:0045202 denotes synapses
T7075 31279-31284 NCBITaxon:9606 denotes human
T7076 31285-31291 UBERON:0000479 denotes tissue
T7077 31359-31365 NCBITaxon:33208 denotes animal
T7078 31444-31457 GO:0001750 denotes outer segment
T7079 31458-31471 GO:0009653 denotes morphogenesis
T7080 31473-31487 GO:0007416 denotes synaptogenesis
T7722 31763-31771 CHEBI:10545 denotes electron
T7723 31794-31797 PR:000005904 denotes Crx
T7724 31839-31851 CHEBI:16842 denotes formaldehyde
T7725 31861-31875 CHEBI:64276 denotes glutaraldehyde
T7726 31891-31896 GO:0007567 denotes natal
T7727 31909-31913 UBERON:0000970 denotes eyes
T7728 31944-31950 UBERON:0000964 denotes cornea
T7729 31978-31981 UBERON:0000970 denotes eye
T7730 32002-32010 CHEBI:50913 denotes fixative
T7731 32015-32027 CHEBI:16842 denotes formaldehyde
T7732 32037-32051 CHEBI:64276 denotes glutaraldehyde
T7733 32082-32088 UBERON:0001773 denotes sclera
T7734 32124-32131 UBERON:0000966 denotes retinas
T7735 32202-32216 CHEBI:64276 denotes glutaraldehyde
T7736 32320-32333 CL:0000210 denotes photoreceptor
T7737 32320-32348 GO:0001750 denotes photoreceptor outer segments
T7738 32368-32374 UBERON:0000479 denotes tissue
T7739 32429-32435 UBERON:0000479 denotes tissue
T7740 32485-32507 CHEBI:30059 denotes potassium ferrocyanide
T7741 32508-32515 CHEBI:60004 denotes mixture
T7742 32661-32672 CHEBI:75211 denotes tannic acid
T7743 32682-32692 CHEBI:16223 denotes cacodylate
T7744 32896-32904 CHEBI:10545 denotes electron
T8030 32927-32935 CHEBI:10545 denotes electron
T8031 32994-33020 UBERON:0001782 denotes retinal pigment epithelium
T8032 33078-33091 UBERON:0003902 denotes neural retina
T8033 33093-33100 UBERON:0000966 denotes Retinae
T8034 33106-33109 PR:000005904 denotes Crx
T8035 33114-33123 PR:000001245 denotes rhodopsin
T8036 33128-33131 PR:000013290 denotes RDS
T8037 33145-33149 UBERON:0000970 denotes eyes
T8038 33191-33199 CHEBI:75958 denotes solution
T8039 33219-33233 CHEBI:64276 denotes glutaraldehyde
T8040 33243-33255 CHEBI:16842 denotes formaldehyde
T8041 33274-33280 UBERON:0000479 denotes Tissue
T8042 33303-33313 CHEBI:16223 denotes cacodylate
T8043 33359-33366 CHEBI:16236 denotes ethanol
T8044 33368-33375 UBERON:0000479 denotes Tissues
T8045 33418-33432 CHEBI:16526 denotes carbon dioxide
T8046 33588-33596 CHEBI:10545 denotes electron
T8343 7992-8006 GO:0001917 denotes inner segments
T8344 8008-8011 UBERON:0001789 denotes onl
T8345 8013-8032 UBERON:0001789 denotes outer nuclear layer
T8346 8019-8026 GO:0005634 denotes nuclear
T8482 8953-8961 CHEBI:10545 denotes electron
T8483 8976-8979 PR:000005904 denotes Crx
T8484 8983-8989 UBERON:0000966 denotes retina
T8485 9021-9029 CHEBI:10545 denotes electron
T8486 9044-9047 PR:000005904 denotes Crx
T8487 9065-9078 GO:0001750 denotes outer segment
T8488 9065-9084 UBERON:0003926 denotes outer segment layer
T8489 9102-9114 GO:0042384 denotes ciliogenesis
T8490 9122-9135 CL:0000210 denotes photoreceptor
T8491 9122-9144 _FRAGMENT denotes photoreceptor layer of
T8492 9152-9158 UBERON:0001787 denotes retina
T8493 9145-9148 PR:000005904 denotes Crx
T8494 9160-9186 GO:0032391 denotes Nonmotile connecting cilia
T8495 9257-9274 GO:0032391 denotes Connecting cilium
T8496 9310-9320 GO:0005874 denotes microtuble
T8497 9337-9343 GO:0005929 denotes cilium
T8498 9350-9356 GO:0005929 denotes cilium
T8499 9393-9405 GO:0005634 denotes cell nucleus
T8500 9407-9408 GO:0005634 denotes n
T8501 9420-9428 GO:0030263 denotes pyknotic
T8502 9456-9462 GO:0031012 denotes matrix
T8503 9464-9466 GO:0031012 denotes mx
T8504 9536-9555 GO:0031988 denotes membranous vesicles
T8505 9581-9594 CL:0000210 denotes photoreceptor
T8506 9634-9648 GO:0001917 denotes inner segments
T8507 9674-9701 GO:0032391 denotes Nonmotile connecting cilium
T8508 9727-9730 PR:000005904 denotes Crx
T8509 9734-9747 CL:0000210 denotes photoreceptor
T8510 9798-9809 GO:0005874 denotes microtubule
T8511 9852-9860 CHEBI:10545 denotes electron
T8512 9881-9900 GO:0031988 denotes membranous vesicles
T8513 9937-9951 GO:0001917 denotes inner segments
T8514 9955-9958 PR:000005904 denotes Crx
T8515 9962-9976 CL:0000210 denotes photoreceptors
T8516 9998-10012 GO:0001917 denotes inner segments
T8517 10029-10036 UBERON:0001773 denotes scleral
T8518 10051-10060 CHEBI:26130 denotes pigmented
T8519 10061-10071 UBERON:0000483 denotes epithelium
T8843 12753-12766 GO:0001750 denotes Outer segment
T8844 12767-12780 GO:0009653 denotes morphogenesis
T8845 12784-12787 PR:000005904 denotes Crx
T8846 12791-12805 CL:0000210 denotes photoreceptors
T8847 12816-12824 CHEBI:10545 denotes electron
T8848 12850-12864 CL:0000210 denotes photoreceptors
T8849 12881-12888 UBERON:0001773 denotes scleral
T8850 12903-12912 CHEBI:26130 denotes pigmented
T8851 12913-12923 UBERON:0000483 denotes epithelium
T8852 12956-12959 PR:000005904 denotes Crx
T8853 12981-12984 PR:000005904 denotes Crx
T8854 13014-13017 PR:000005904 denotes Crx
T8855 13021-13027 UBERON:0000966 denotes retina
T8856 13038-13054 GO:0032391 denotes connecting cilia
T8857 13059-13061 GO:0032391 denotes cc
T8858 13099-13113 GO:0001750 denotes outer segments
T8859 13128-13131 PR:000005904 denotes Crx
T8860 13135-13148 GO:0001750 denotes outer segment
T8861 13179-13193 GO:0001750 denotes outer segments
T8862 13227-13229 GO:0001750 denotes os
T8863 13255-13257 GO:0001750 denotes os
T8864 13263-13266 PR:000005904 denotes Crx
T8865 13270-13284 CL:0000210 denotes photoreceptors
T8866 13290-13306 GO:0032391 denotes connecting cilia
T8867 13346-13362 GO:0032391 denotes connecting cilia
T8868 13411-13424 GO:0001750 denotes outer segment
T8869 13452-13469 GO:0032391 denotes connecting cilium
T8870 13480-13482 GO:0032391 denotes cc
T8871 13516-13519 PR:000005904 denotes Crx
T8872 13573-13589 GO:0032391 denotes connecting cilia
T8873 13603-13606 PR:000005904 denotes Crx
T8874 13614-13616 GO:0032391 denotes cc
T9162 13661-13669 CHEBI:10545 denotes electron
T9163 13685-13688 PR:000005904 denotes Crx
T9164 13692-13706 CL:0000210 denotes photoreceptors
T9165 13714-13727 CL:0000210 denotes photoreceptor
T9166 13714-13733 UBERON:0001787 denotes photoreceptor layer
T9167 13745-13758 CL:0000210 denotes Photoreceptor
T9168 13745-13767 _FRAGMENT denotes Photoreceptor layer of
T9169 13775-13781 UBERON:0001787 denotes retina
T9170 13768-13771 PR:000005904 denotes Crx
T9171 13804-13817 GO:0001750 denotes outer segment
T9172 13851-13864 CL:0000210 denotes photoreceptor
T9173 13851-13881 GO:0032391 denotes photoreceptor connecting cilia
T9174 13883-13885 GO:0032391 denotes cc
T9175 13892-13895 PR:000005904 denotes Crx
T9176 13899-13913 CL:0000210 denotes photoreceptors
T9177 13924-13940 GO:0032391 denotes connecting cilia
T9178 13942-13944 GO:0032391 denotes cc
T9179 13984-13997 GO:0001750 denotes outer segment
T9294 14645-14653 CHEBI:10545 denotes electron
T9295 14690-14699 PR:000001245 denotes rhodopsin
T9296 14707-14721 CL:0000210 denotes photoreceptors
T9297 14746-14753 UBERON:0001773 denotes scleral
T9298 14768-14777 CHEBI:26130 denotes pigmented
T9299 14778-14788 UBERON:0000483 denotes epithelium
T9300 14798-14800 GO:0032391 denotes cc
T9301 14802-14819 GO:0032391 denotes connecting cilium
T9302 14821-14823 GO:0001917 denotes is
T9303 14825-14838 GO:0001917 denotes inner segment
T9395 16514-16522 CHEBI:10545 denotes electron
T9396 16542-16563 UBERON:0001790 denotes outer plexiform layer
T9397 16567-16570 PR:000005904 denotes Crx
T9398 16574-16581 UBERON:0000966 denotes retinas
T9399 16590-16593 PR:000005904 denotes Crx
T9400 16597-16603 UBERON:0000966 denotes retina
T9401 16625-16628 CL:0000604 denotes rod
T9402 16625-16638 GO:0044317 denotes rod spherules
T9403 16691-16700 GO:0044317 denotes spherules
T9404 16754-16761 GO:0045202 denotes synapse
T9405 16787-16791 CL:0000573 denotes Cone
T9406 16819-16827 GO:0044316 denotes pedicles
T9407 16859-16867 GO:0045202 denotes synapses
T9408 16951-16954 PR:000005904 denotes Crx
T9409 17006-17027 _FRAGMENT denotes outer plexiform layer
T9410 17034-17036 _FRAGMENT denotes of
T9411 17044-17051 UBERON:0001790 denotes retinas
T9412 17029-17032 _FRAGMENT denotes OPL
T9413 17037-17040 PR:000005904 denotes Crx
T9414 17053-17066 CL:0000210 denotes photoreceptor
T9415 17135-17143 GO:0044316 denotes pedicles
T9416 17148-17157 GO:0044317 denotes spherules
T9417 17286-17304 GO:0044456 denotes synapse components
T9418 17510-17513 UBERON:0001790 denotes opl
T9419 17515-17536 UBERON:0001790 denotes outer plexiform layer
T9718 17579-17587 CHEBI:10545 denotes electron
T9719 17607-17628 UBERON:0001790 denotes outer plexiform layer
T9720 17632-17635 PR:000005904 denotes Crx
T9721 17639-17646 UBERON:0000966 denotes retinas
T9722 17659-17662 PR:000005904 denotes Crx
T9723 17666-17669 CL:0000604 denotes rod
T9724 17666-17679 GO:0044317 denotes rod spherules
T9725 17712-17719 GO:0045202 denotes synapse
T9726 17749-17757 GO:0044317 denotes spherule
T9727 17800-17803 PR:000005904 denotes Crx
T9728 17807-17810 CL:0000604 denotes rod
T9729 17858-17859 CL:0000604 denotes r
T9730 17866-17875 GO:0042995 denotes processes
T9731 17882-17898 CL:0000745 denotes horizontal cells
T9732 17900-17901 CL:0000745 denotes h
T9733 17918-17921 CL:0000604 denotes rod
T9734 17947-17954 GO:0042995 denotes process
T9735 17960-17972 GO:0098794 denotes postsynaptic
T9736 17981-17989 GO:0030425 denotes dendrite
T9737 18051-18068 GO:0008021 denotes synaptic vesicles
T9738 18074-18088 GO:0030135 denotes coated vesicle
T9739 18110-18123 GO:0005886 denotes cell membrane
T9740 18157-18163 _FRAGMENT denotes OPL of
T9741 18171-18178 UBERON:0001790 denotes retinas
T9742 18164-18167 PR:000005904 denotes Crx
T9743 18180-18193 CL:0000210 denotes photoreceptor
T9744 18264-18281 GO:0008021 denotes synaptic vesicles
T9745 18375-18393 GO:0044456 denotes synapse components
T9746 18416-18425 GO:0044317 denotes spherules
T9747 18430-18438 GO:0044316 denotes pedicles
T9748 18598-18615 GO:0097060 denotes synaptic membrane
T9749 18687-18694 GO:0005634 denotes nuclear
T9750 18707-18708 CL:0000745 denotes H
T9751 18710-18725 CL:0000745 denotes horizontal cell
T9752 18727-18728 CL:0000103 denotes B
T9753 18730-18742 CL:0000103 denotes bipolar cell
T9754 18744-18745 GO:0005634 denotes N
T9755 18747-18754 GO:0005634 denotes nucleus
T8224 7650-7664 GO:0001917 denotes inner segments
T8225 7666-7669 UBERON:0001789 denotes onl
T8226 7671-7690 UBERON:0001789 denotes outer nuclear layer
T8227 7677-7684 GO:0005634 denotes nuclear
T8228 7696-7709 CL:0000210 denotes photoreceptor
T8229 7710-7716 GO:0005634 denotes nuclei
T7639 31559-31563 NCBITaxon:10088 denotes Mice
T7640 31564-31567 PR:000005904 denotes Crx
T7641 31571-31575 NCBITaxon:10088 denotes mice
T7642 31619-31627 PR:000001245 denotes Rhodosin
T7643 31633-31637 NCBITaxon:10088 denotes mice
T7644 31701-31704 PR:000013290 denotes Rds
T7645 31705-31709 NCBITaxon:10088 denotes mice
T8214 7515-7523 CHEBI:10545 denotes electron
T8215 7548-7554 UBERON:0000966 denotes retina
T8216 7569-7572 PR:000005904 denotes Crx
T8217 7584-7587 PR:000005904 denotes Crx
T8218 7591-7598 UBERON:0000966 denotes retinas
T8219 7604-7613 CHEBI:26130 denotes pigmented
T8220 7614-7624 UBERON:0000483 denotes epithelium
T8221 7626-7628 GO:0001750 denotes os
T8222 7630-7644 GO:0001750 denotes outer segments
T8223 7646-7648 GO:0001917 denotes is
T8328 7771-7779 CHEBI:10545 denotes electron
T8329 7798-7811 GO:0001750 denotes outer segment
T8330 7798-7817 UBERON:0003926 denotes outer segment layer
T8331 7821-7824 PR:000005904 denotes Crx
T8332 7828-7834 UBERON:0000966 denotes retina
T8333 7843-7860 _FRAGMENT denotes Inner segments of
T8334 7868-7882 GO:0001917 denotes photoreceptors
T8335 7861-7864 PR:000005904 denotes Crx
T8336 7868-7882 CL:0000210 denotes photoreceptors
T8337 7900-7912 GO:0005739 denotes mitochondria
T8338 7914-7915 GO:0005739 denotes m
T8339 7942-7945 PR:000005904 denotes Crx
T8340 7966-7975 CHEBI:26130 denotes pigmented
T8341 7976-7986 UBERON:0000483 denotes epithelium
T8342 7988-7990 GO:0001917 denotes is
T579 5043-5046 CL:0000604 denotes rod
T580 5055-5064 GO:0030425 denotes dendrites
T581 5069-5083 GO:0043679 denotes axonal endings
T582 5087-5103 CL:0000745 denotes horizontal cells
T583 5110-5117 GO:0045202 denotes synapse
T584 5170-5181 GO:0098793 denotes presynaptic
T585 5182-5191 GO:0005737 denotes cytoplasm
T586 5193-5197 CL:0000573 denotes Cone
T2008 8056-8057 UBERON:0001789 denotes o
T2009 8057-8059 UBERON:0001789 denotes re
T2010 8058-8059 GO:0005634 denotes e
T2011 8059-8065 CL:0000210 denotes ceptor
T2012 8066-8067 GO:0005634 denotes i
T2013 8069-8071 CHEBI:10545 denotes er
T2014 8072-8079 GO:0001750 denotes segment
T2015 8072-8079 UBERON:0003926 denotes segment
T2016 8079-8081 _FRAGMENT denotes s
T2017 8081-8082 GO:0005739 denotes a
T2018 8087-8089 CHEBI:26130 denotes te
T2019 8089-8099 GO:0001917 denotes r segments
T2020 8100-8103 UBERON:0001789 denotes are
T2021 8100-8102 GO:0005634 denotes ar
T2022 8116-8144 GO:0032391 denotes non-motile connecting cilium
T2023 8197-8208 GO:0005874 denotes microtubule
T2024 8259-8262 PR:000005904 denotes Crx
T2025 8266-8273 UBERON:0000966 denotes retinas
T2026 8302-8318 GO:0032391 denotes connecting cilia
T2027 8364-8380 GO:0032391 denotes connecting cilia
T2028 8428-8439 GO:0005874 denotes microtubule
T2029 8481-8498 GO:0032391 denotes connecting cilium
T2030 8699-8712 GO:0001917 denotes inner segment
T2031 8724-8736 GO:0042384 denotes ciliogenesis
T2032 8763-8766 PR:000005904 denotes Crx
T2033 8770-8784 CL:0000210 denotes photoreceptors
T2034 8798-8801 PR:000005904 denotes Crx
T2035 8805-8812 UBERON:0000966 denotes retinas
T2036 8817-8845 UBERON:0001782 denotes retinal pigmented epithelium
T2037 8825-8834 CHEBI:26130 denotes pigmented
T2038 10106-10108 GO:0030263 denotes ti
T2039 10111-10112 GO:0031012 denotes t
T2040 10118-10119 GO:0031988 denotes c
T2041 10121-10122 CL:0000210 denotes p
T2042 10123-10124 GO:0005874 denotes e
T2043 10128-10131 GO:0031988 denotes bse
T2044 10132-10134 CL:0000210 denotes ce
T2045 10139-10152 GO:0001750 denotes uter segments
T2046 10154-10157 PR:000005904 denotes Crx
T2047 10161-10168 UBERON:0000966 denotes retinas
T2048 10218-10231 GO:0001750 denotes outer segment
T2049 10218-10237 UBERON:0003926 denotes outer segment layer
T2050 10272-10278 GO:0031012 denotes matrix
T2057 10687-10700 GO:0001750 denotes outer segment
T2058 10687-10706 UBERON:0003926 denotes outer segment layer
T2059 10727-10735 GO:0031982 denotes vesicles
T2060 10819-10833 GO:0001917 denotes inner segments
T2061 10847-10855 CHEBI:10545 denotes electron
T2062 10920-10934 GO:0001917 denotes inner segments
T2063 10992-11008 _FRAGMENT denotes morphogenesis of
T2064 11016-11030 GO:0008594 denotes photoreceptors
T2065 11009-11012 PR:000005904 denotes Crx
T2066 11016-11030 CL:0000210 denotes photoreceptors
T2067 11047-11060 GO:0001750 denotes outer segment
T2068 11047-11066 UBERON:0003926 denotes outer segment layer
T2069 11090-11098 CHEBI:10545 denotes electron
T2070 11144-11147 PR:000005904 denotes Crx
T2071 11151-11158 UBERON:0000966 denotes retinas
T2072 11160-11173 CL:0000210 denotes photoreceptor
T2073 11160-11188 GO:0001917 denotes photoreceptor inner segments
T2074 11190-11206 GO:0032391 denotes connecting cilia
T2075 11234-11247 GO:0001750 denotes outer segment
T2076 11284-11287 PR:000005904 denotes Crx
T2077 11291-11297 UBERON:0000966 denotes retina
T2078 11319-11336 GO:0032391 denotes connecting cilium
T2079 11361-11375 GO:0001917 denotes inner segments
T2080 11473-11481 CHEBI:10545 denotes electron
T2081 11567-11570 PR:000005904 denotes Crx
T2082 11578-11581 PR:000005904 denotes Crx
T2083 11585-11599 CL:0000210 denotes photoreceptors
T2084 11620-11634 GO:0001750 denotes outer segments
T2085 11649-11652 PR:000005904 denotes Crx
T2086 11656-11670 CL:0000210 denotes photoreceptors
T2087 11732-11736 GO:0045177 denotes apex
T2088 11757-11760 PR:000005904 denotes Crx
T2089 11764-11771 UBERON:0000966 denotes retinae
T2116 14087-14090 PR:000005904 denotes Crx
T2117 14094-14108 CL:0000210 denotes photoreceptors
T2118 14125-14134 PR:000001245 denotes rhodopsin
T2119 14156-14170 CL:0000210 denotes photoreceptors
T2120 14172-14181 PR:000001245 denotes Rhodopsin
T2121 14205-14218 CL:0000210 denotes photoreceptor
T2122 14228-14233 SO:0000704 denotes genes
T2123 14240-14250 GO:0010467 denotes expression
T2126 14360-14365 SO:0000704 denotes genes
R208 T574 T573 _lexicallyChainedTo cells,horizontal
R209 T591 T590 _lexicallyChainedTo bipolar cells,on
R210 T596 T595 _lexicallyChainedTo bipolar cells,off
R211 T600 T599 _lexicallyChainedTo synapses,formation of
R1142 T2064 T2063 _lexicallyChainedTo photoreceptors,morphogenesis of
R2105 T3548 T3547 _lexicallyChainedTo cells,processes from
R2106 T3557 T3556 _lexicallyChainedTo cell,horizontal
R2107 T3565 T3564 _lexicallyChainedTo retinas,OPL of
R2518 T4328 T4327 _lexicallyChainedTo membranes,breakdown of
R2519 T4378 T4377 _lexicallyChainedTo R6,photoreceptors
R2520 T4384 T4383 _lexicallyChainedTo photoreceptors,R1
R3490 T5980 T5979 _lexicallyChainedTo retinas,outer plexiform layer of
R4244 T7060 T7059 _lexicallyChainedTo tissue,formation of
R5116 T8334 T8333 _lexicallyChainedTo photoreceptors,Inner segments of
R5179 T8492 T8491 _lexicallyChainedTo retina,photoreceptor layer of
R5614 T9169 T9168 _lexicallyChainedTo retina,Photoreceptor layer of
R5737 T9410 T9409 _lexicallyChainedTo of,outer plexiform layer
R5738 T9410 T9412 _lexicallyChainedTo of,OPL
R5739 T9411 T9410 _lexicallyChainedTo retinas,of
R5936 T9741 T9740 _lexicallyChainedTo retinas,OPL of
R1 T44 T43 _lexicallyChainedTo retina,development of
R2 T48 T47 _lexicallyChainedTo of photoreceptor cells,development
R204 T490 T489 _lexicallyChainedTo photoreceptors,development of
R205 T529 T528 _lexicallyChainedTo of,differentiation
R206 T530 T529 _lexicallyChainedTo cells,of
R207 T572 T571 _lexicallyChainedTo cells,processes of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T116 47-56 VBN denotes perturbed
T117 0-96 sentence denotes Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice
T118 15-18 CC denotes and
T119 19-24 JJ denotes outer
T120 25-32 NN denotes segment
T121 33-42 NN denotes formation
T122 43-46 VBP denotes are
T123 57-59 IN denotes in
T124 60-63 DT denotes the
T125 71-77 NN denotes retina
T126 64-70 JJ denotes neural
T127 78-80 IN denotes of
T128 81-84 NN denotes Crx
T129 92-96 NNS denotes mice
T130 85-91 NN denotes mutant
T131 96-97 sentence denotes
T132 107-117 sentence denotes Background
T133 107-117 NN denotes Background
T134 117-214 sentence denotes In Leber's congenital amaurosis (LCA), affected individuals are blind, or nearly so, from birth.
T135 118-120 IN denotes In
T136 178-181 VBP denotes are
T137 121-126 NNP denotes Leber
T138 140-149 NN denotes amaurosis
T139 126-128 POS denotes 's
T140 129-139 JJ denotes congenital
T141 150-151 -LRB- denotes (
T142 151-154 NN denotes LCA
T143 154-155 -RRB- denotes )
T144 155-157 , denotes ,
T145 157-165 VBN denotes affected
T146 166-177 NNS denotes individuals
T147 182-187 JJ denotes blind
T148 187-189 , denotes ,
T149 189-191 CC denotes or
T150 192-198 RB denotes nearly
T151 199-201 RB denotes so
T152 201-203 , denotes ,
T153 203-207 IN denotes from
T154 208-213 NN denotes birth
T155 213-214 . denotes .
T156 214-283 sentence denotes This early onset suggests abnormal development of the neural retina.
T157 215-219 DT denotes This
T158 226-231 NN denotes onset
T159 220-225 JJ denotes early
T160 232-240 VBZ denotes suggests
T161 241-249 JJ denotes abnormal
T162 250-261 NN denotes development
T163 262-264 IN denotes of
T164 265-268 DT denotes the
T165 276-282 NN denotes retina
T166 269-275 JJ denotes neural
T167 282-283 . denotes .
T168 283-421 sentence denotes Mutations in genes that affect the development and/or function of photoreceptor cells have been found to be responsible in some families.
T169 284-293 NNS denotes Mutations
T170 380-385 VBN denotes found
T171 294-296 IN denotes in
T172 297-302 NNS denotes genes
T173 303-307 WDT denotes that
T174 308-314 VBP denotes affect
T175 315-318 DT denotes the
T176 319-330 NN denotes development
T177 331-334 CC denotes and
T178 334-335 HYPH denotes /
T179 335-337 CC denotes or
T180 338-346 NN denotes function
T181 347-349 IN denotes of
T182 350-363 NN denotes photoreceptor
T183 364-369 NNS denotes cells
T184 370-374 VBP denotes have
T185 375-379 VBN denotes been
T186 386-388 TO denotes to
T187 389-391 VB denotes be
T188 392-403 JJ denotes responsible
T189 404-406 IN denotes in
T190 407-411 DT denotes some
T191 412-420 NNS denotes families
T192 420-421 . denotes .
T193 421-502 sentence denotes These examples include mutations in the photoreceptor transcription factor, Crx.
T194 422-427 DT denotes These
T195 428-436 NNS denotes examples
T196 437-444 VBP denotes include
T197 445-454 NNS denotes mutations
T198 455-457 IN denotes in
T199 458-461 DT denotes the
T200 490-496 NN denotes factor
T201 462-475 NN denotes photoreceptor
T202 476-489 NN denotes transcription
T203 496-498 , denotes ,
T204 498-501 NN denotes Crx
T205 501-502 . denotes .
T206 502-511 sentence denotes Results
T207 504-511 NNS denotes Results
T208 511-628 sentence denotes A Crx mutant strain of mice was created to serve as a model for LCA and to provide more insight into Crx's function.
T209 512-513 DT denotes A
T210 525-531 NN denotes strain
T211 514-517 NN denotes Crx
T212 518-524 JJ denotes mutant
T213 544-551 VBN denotes created
T214 532-534 IN denotes of
T215 535-539 NNS denotes mice
T216 540-543 VBD denotes was
T217 552-554 TO denotes to
T218 555-560 VB denotes serve
T219 561-563 IN denotes as
T220 564-565 DT denotes a
T221 566-571 NN denotes model
T222 572-575 IN denotes for
T223 576-579 NN denotes LCA
T224 580-583 CC denotes and
T225 584-586 TO denotes to
T226 587-594 VB denotes provide
T227 595-599 JJR denotes more
T228 600-607 NN denotes insight
T229 608-612 IN denotes into
T230 613-616 NN denotes Crx
T231 619-627 NN denotes function
T232 616-618 POS denotes 's
T233 627-628 . denotes .
T234 628-730 sentence denotes In this study, an ultrastructural analysis of the developing retina in Crx mutant mice was performed.
T235 629-631 IN denotes In
T236 720-729 VBN denotes performed
T237 632-636 DT denotes this
T238 637-642 NN denotes study
T239 642-644 , denotes ,
T240 644-646 DT denotes an
T241 663-671 NN denotes analysis
T242 647-662 JJ denotes ultrastructural
T243 672-674 IN denotes of
T244 675-678 DT denotes the
T245 690-696 NN denotes retina
T246 679-689 VBG denotes developing
T247 697-699 IN denotes in
T248 700-703 NN denotes Crx
T249 711-715 NNS denotes mice
T250 704-710 NN denotes mutant
T251 716-719 VBD denotes was
T252 729-730 . denotes .
T253 730-878 sentence denotes Outer segment morphogenesis was found to be blocked at the elongation stage, leading to a failure in production of the phototransduction apparatus.
T254 731-736 JJ denotes Outer
T255 745-758 NN denotes morphogenesis
T256 737-744 NN denotes segment
T257 763-768 VBN denotes found
T258 759-762 VBD denotes was
T259 769-771 TO denotes to
T260 775-782 VBN denotes blocked
T261 772-774 VB denotes be
T262 783-785 IN denotes at
T263 786-789 DT denotes the
T264 801-806 NN denotes stage
T265 790-800 NN denotes elongation
T266 806-808 , denotes ,
T267 808-815 VBG denotes leading
T268 816-818 IN denotes to
T269 819-820 DT denotes a
T270 821-828 NN denotes failure
T271 829-831 IN denotes in
T272 832-842 NN denotes production
T273 843-845 IN denotes of
T274 846-849 DT denotes the
T275 868-877 NN denotes apparatus
T276 850-867 NN denotes phototransduction
T277 877-878 . denotes .
T278 878-987 sentence denotes Further, Crx-/- photoreceptors demonstrated severely abnormal synaptic endings in the outer plexiform layer.
T279 879-886 RB denotes Further
T280 910-922 VBD denotes demonstrated
T281 886-888 , denotes ,
T282 888-891 NN denotes Crx
T283 895-909 NNS denotes photoreceptors
T284 891-892 SYM denotes -
T285 892-893 HYPH denotes /
T286 893-894 SYM denotes -
T287 923-931 RB denotes severely
T288 932-940 JJ denotes abnormal
T289 950-957 NNS denotes endings
T290 941-949 JJ denotes synaptic
T291 958-960 IN denotes in
T292 961-964 DT denotes the
T293 981-986 NN denotes layer
T294 965-970 JJ denotes outer
T295 971-980 NN denotes plexiform
T296 986-987 . denotes .
T297 987-1000 sentence denotes Conclusions
T298 989-1000 NNS denotes Conclusions
T299 1000-1080 sentence denotes This is the first report of a synaptogenesis defect in an animal model for LCA.
T300 1001-1005 DT denotes This
T301 1006-1008 VBZ denotes is
T302 1009-1012 DT denotes the
T303 1019-1025 NN denotes report
T304 1013-1018 JJ denotes first
T305 1026-1028 IN denotes of
T306 1029-1030 DT denotes a
T307 1046-1052 NN denotes defect
T308 1031-1045 NN denotes synaptogenesis
T309 1053-1055 IN denotes in
T310 1056-1058 DT denotes an
T311 1066-1071 NN denotes model
T312 1059-1065 NN denotes animal
T313 1072-1075 IN denotes for
T314 1076-1079 NN denotes LCA
T315 1079-1080 . denotes .
T316 1080-1243 sentence denotes These data confirm the essential role this gene plays in multiple aspects of photoreceptor development and extend our understanding of the basic pathology of LCA.
T317 1081-1086 DT denotes These
T318 1087-1091 NNS denotes data
T319 1092-1099 VBP denotes confirm
T320 1100-1103 DT denotes the
T321 1114-1118 NN denotes role
T322 1104-1113 JJ denotes essential
T323 1119-1123 DT denotes this
T324 1124-1128 NN denotes gene
T325 1129-1134 VBZ denotes plays
T326 1135-1137 IN denotes in
T327 1138-1146 JJ denotes multiple
T328 1147-1154 NNS denotes aspects
T329 1155-1157 IN denotes of
T330 1158-1171 NN denotes photoreceptor
T331 1172-1183 NN denotes development
T332 1184-1187 CC denotes and
T333 1188-1194 VBP denotes extend
T334 1195-1198 PRP$ denotes our
T335 1199-1212 NN denotes understanding
T336 1213-1215 IN denotes of
T337 1216-1219 DT denotes the
T338 1226-1235 NN denotes pathology
T339 1220-1225 JJ denotes basic
T340 1236-1238 IN denotes of
T341 1239-1242 NN denotes LCA
T342 1242-1243 . denotes .
T822 1256-1269 NN denotes Photoreceptor
T823 1270-1275 NNS denotes cells
T824 1276-1280 VBP denotes play
T825 1281-1282 DT denotes a
T826 1291-1295 NN denotes role
T827 1283-1290 JJ denotes primary
T828 1296-1298 IN denotes in
T829 1299-1305 NN denotes vision
T830 1306-1308 IN denotes by
T831 1309-1318 VBG denotes capturing
T832 1319-1324 NN denotes light
T833 1325-1331 NN denotes energy
T834 1332-1335 CC denotes and
T835 1336-1346 VBG denotes converting
T836 1347-1349 PRP denotes it
T837 1350-1354 IN denotes into
T838 1355-1361 JJ denotes neural
T839 1362-1369 NNS denotes stimuli
T840 1369-1370 . denotes .
T841 1370-1456 sentence denotes These sensory neurons are a shared element in all organisms capable of sensing light.
T842 1371-1376 DT denotes These
T843 1385-1392 NNS denotes neurons
T844 1377-1384 JJ denotes sensory
T845 1393-1396 VBP denotes are
T846 1397-1398 DT denotes a
T847 1406-1413 NN denotes element
T848 1399-1405 VBN denotes shared
T849 1414-1416 IN denotes in
T850 1417-1420 DT denotes all
T851 1421-1430 NNS denotes organisms
T852 1431-1438 JJ denotes capable
T853 1439-1441 IN denotes of
T854 1442-1449 VBG denotes sensing
T855 1450-1455 NN denotes light
T856 1455-1456 . denotes .
T857 1456-1596 sentence denotes In humans, genetic diseases of the eye are common and the primary site of disease is most frequently photoreceptors (for review see [1-3]).
T858 1457-1459 IN denotes In
T859 1496-1499 VBP denotes are
T860 1460-1466 NNS denotes humans
T861 1466-1468 , denotes ,
T862 1468-1475 JJ denotes genetic
T863 1476-1484 NNS denotes diseases
T864 1485-1487 IN denotes of
T865 1488-1491 DT denotes the
T866 1492-1495 NN denotes eye
T867 1500-1506 JJ denotes common
T868 1507-1510 CC denotes and
T869 1511-1514 DT denotes the
T870 1523-1527 NN denotes site
T871 1515-1522 JJ denotes primary
T872 1539-1541 VBZ denotes is
T873 1528-1530 IN denotes of
T874 1531-1538 NN denotes disease
T875 1542-1546 RBS denotes most
T876 1547-1557 RB denotes frequently
T877 1558-1572 NNS denotes photoreceptors
T878 1573-1574 -LRB- denotes (
T879 1585-1588 VBP denotes see
T880 1574-1577 IN denotes for
T881 1578-1584 NN denotes review
T882 1589-1590 -LRB- denotes [
T883 1590-1591 CD denotes 1
T884 1591-1592 SYM denotes -
T885 1592-1593 CD denotes 3
T886 1593-1594 -RRB- denotes ]
T887 1594-1595 -RRB- denotes )
T888 1595-1596 . denotes .
T889 1596-1718 sentence denotes Photoreceptors have been well studied, particularly with respect to the biochemistry and physiology of phototransduction.
T890 1597-1611 NNS denotes Photoreceptors
T891 1627-1634 VBN denotes studied
T892 1612-1616 VBP denotes have
T893 1617-1621 VBN denotes been
T894 1622-1626 RB denotes well
T895 1634-1636 , denotes ,
T896 1636-1648 RB denotes particularly
T897 1649-1653 IN denotes with
T898 1654-1661 NN denotes respect
T899 1662-1664 IN denotes to
T900 1665-1668 DT denotes the
T901 1669-1681 NN denotes biochemistry
T902 1682-1685 CC denotes and
T903 1686-1696 NN denotes physiology
T904 1697-1699 IN denotes of
T905 1700-1717 NN denotes phototransduction
T906 1717-1718 . denotes .
T907 1718-1835 sentence denotes Insight into the development of vertebrate photoreceptors, however, has lagged behind our understanding of function.
T908 1719-1726 NN denotes Insight
T909 1791-1797 VBN denotes lagged
T910 1727-1731 IN denotes into
T911 1732-1735 DT denotes the
T912 1736-1747 NN denotes development
T913 1748-1750 IN denotes of
T914 1751-1761 NN denotes vertebrate
T915 1762-1776 NNS denotes photoreceptors
T916 1776-1778 , denotes ,
T917 1778-1785 RB denotes however
T918 1785-1787 , denotes ,
T919 1787-1790 VBZ denotes has
T920 1798-1804 IN denotes behind
T921 1805-1808 PRP$ denotes our
T922 1809-1822 NN denotes understanding
T923 1823-1825 IN denotes of
T924 1826-1834 NN denotes function
T925 1834-1835 . denotes .
T926 1835-1963 sentence denotes Only recently have the first molecular mechanisms regulating photoreceptor development been identified (for review see, [2,4]).
T927 1836-1840 RB denotes Only
T928 1841-1849 RB denotes recently
T929 1928-1938 VBN denotes identified
T930 1850-1854 VB denotes have
T931 1855-1858 DT denotes the
T932 1875-1885 NNS denotes mechanisms
T933 1859-1864 JJ denotes first
T934 1865-1874 JJ denotes molecular
T935 1886-1896 VBG denotes regulating
T936 1897-1910 NN denotes photoreceptor
T937 1911-1922 NN denotes development
T938 1923-1927 VBN denotes been
T939 1939-1940 -LRB- denotes (
T940 1951-1954 VB denotes see
T941 1940-1943 IN denotes for
T942 1944-1950 NN denotes review
T943 1954-1956 , denotes ,
T944 1956-1957 -LRB- denotes [
T945 1957-1958 CD denotes 2
T946 1959-1960 CD denotes 4
T947 1958-1959 , denotes ,
T948 1960-1961 -RRB- denotes ]
T949 1961-1962 -RRB- denotes )
T950 1962-1963 . denotes .
T951 1963-2126 sentence denotes Crx (cone-rod homeobox) is an otx-family homeobox gene expressed predominantly in photoreceptors, from early in their development through to the adult ages [5-7].
T952 1964-1967 NN denotes Crx
T953 1988-1990 VBZ denotes is
T954 1968-1969 -LRB- denotes (
T955 1969-1973 NN denotes cone
T956 1974-1977 NN denotes rod
T957 1973-1974 HYPH denotes -
T958 1978-1986 NN denotes homeobox
T959 1986-1987 -RRB- denotes )
T960 1991-1993 DT denotes an
T961 2014-2018 NN denotes gene
T962 1994-1997 NN denotes otx
T963 1998-2004 NN denotes family
T964 1997-1998 HYPH denotes -
T965 2005-2013 NN denotes homeobox
T966 2019-2028 VBN denotes expressed
T967 2029-2042 RB denotes predominantly
T968 2043-2045 IN denotes in
T969 2046-2060 NNS denotes photoreceptors
T970 2060-2062 , denotes ,
T971 2062-2066 IN denotes from
T972 2067-2072 RB denotes early
T973 2073-2075 IN denotes in
T974 2076-2081 PRP$ denotes their
T975 2082-2093 NN denotes development
T976 2094-2101 IN denotes through
T977 2102-2104 IN denotes to
T978 2105-2108 DT denotes the
T979 2115-2119 NNS denotes ages
T980 2109-2114 JJ denotes adult
T981 2120-2121 -LRB- denotes [
T982 2121-2122 CD denotes 5
T983 2122-2123 SYM denotes -
T984 2123-2124 CD denotes 7
T985 2124-2125 -RRB- denotes ]
T986 2125-2126 . denotes .
T987 2126-2277 sentence denotes Crx gene expression is critically dependent upon Otx2, another member of the same homeobox family which is expressed in early photoreceptor cells [8].
T988 2127-2130 NN denotes Crx
T989 2136-2146 NN denotes expression
T990 2131-2135 NN denotes gene
T991 2147-2149 VBZ denotes is
T992 2150-2160 RB denotes critically
T993 2161-2170 JJ denotes dependent
T994 2171-2175 IN denotes upon
T995 2176-2180 NN denotes Otx2
T996 2180-2182 , denotes ,
T997 2182-2189 DT denotes another
T998 2190-2196 NN denotes member
T999 2197-2199 IN denotes of
T1000 2200-2203 DT denotes the
T1001 2218-2224 NN denotes family
T1002 2204-2208 JJ denotes same
T1003 2209-2217 NN denotes homeobox
T1004 2225-2230 WDT denotes which
T1005 2234-2243 VBN denotes expressed
T1006 2231-2233 VBZ denotes is
T1007 2244-2246 IN denotes in
T1008 2247-2252 JJ denotes early
T1009 2267-2272 NNS denotes cells
T1010 2253-2266 NN denotes photoreceptor
T1011 2273-2274 -LRB- denotes [
T1012 2274-2275 CD denotes 8
T1013 2275-2276 -RRB- denotes ]
T1014 2276-2277 . denotes .
T1015 2277-2449 sentence denotes In rod photoreceptors, Crx appears to work in concert with Nrl, a leucine zipper protein that is also restricted in its expression in the retina to rod photoreceptors [9].
T1016 2278-2280 IN denotes In
T1017 2305-2312 VBZ denotes appears
T1018 2281-2284 NN denotes rod
T1019 2285-2299 NNS denotes photoreceptors
T1020 2299-2301 , denotes ,
T1021 2301-2304 NN denotes Crx
T1022 2313-2315 TO denotes to
T1023 2316-2320 VB denotes work
T1024 2321-2323 IN denotes in
T1025 2324-2331 NN denotes concert
T1026 2332-2336 IN denotes with
T1027 2337-2340 NN denotes Nrl
T1028 2340-2342 , denotes ,
T1029 2342-2343 DT denotes a
T1030 2359-2366 NN denotes protein
T1031 2344-2351 NN denotes leucine
T1032 2352-2358 NN denotes zipper
T1033 2367-2371 WDT denotes that
T1034 2380-2390 VBN denotes restricted
T1035 2372-2374 VBZ denotes is
T1036 2375-2379 RB denotes also
T1037 2391-2393 IN denotes in
T1038 2394-2397 PRP$ denotes its
T1039 2398-2408 NN denotes expression
T1040 2409-2411 IN denotes in
T1041 2412-2415 DT denotes the
T1042 2416-2422 NN denotes retina
T1043 2423-2425 IN denotes to
T1044 2426-2429 NN denotes rod
T1045 2430-2444 NNS denotes photoreceptors
T1046 2445-2446 -LRB- denotes [
T1047 2446-2447 CD denotes 9
T1048 2447-2448 -RRB- denotes ]
T1049 2448-2449 . denotes .
T1050 2449-2596 sentence denotes Many photoreceptor-specific genes have putative Crx-binding elements in their regulatory regions [10], including rhodopsin [11] and arrestin [12].
T1051 2450-2454 JJ denotes Many
T1052 2478-2483 NNS denotes genes
T1053 2455-2468 NN denotes photoreceptor
T1054 2469-2477 JJ denotes specific
T1055 2468-2469 HYPH denotes -
T1056 2484-2488 VBP denotes have
T1057 2489-2497 JJ denotes putative
T1058 2510-2518 NNS denotes elements
T1059 2498-2501 NN denotes Crx
T1060 2502-2509 VBG denotes binding
T1061 2501-2502 HYPH denotes -
T1062 2519-2521 IN denotes in
T1063 2522-2527 PRP$ denotes their
T1064 2539-2546 NNS denotes regions
T1065 2528-2538 JJ denotes regulatory
T1066 2547-2548 -LRB- denotes [
T1067 2548-2550 CD denotes 10
T1068 2550-2551 -RRB- denotes ]
T1069 2551-2553 , denotes ,
T1070 2553-2562 VBG denotes including
T1071 2563-2572 NN denotes rhodopsin
T1072 2573-2574 -LRB- denotes [
T1073 2574-2576 CD denotes 11
T1074 2576-2577 -RRB- denotes ]
T1075 2578-2581 CC denotes and
T1076 2582-2590 NN denotes arrestin
T1077 2591-2592 -LRB- denotes [
T1078 2592-2594 CD denotes 12
T1079 2594-2595 -RRB- denotes ]
T1080 2595-2596 . denotes .
T1081 2596-2772 sentence denotes Mutations in Crx have been associated with several human diseases that lead to blindness, including cone-rod dystrophy 2 [6,13,14], retinitis pigmentosa [14], and LCA [14-16].
T1082 2597-2606 NNS denotes Mutations
T1083 2624-2634 VBN denotes associated
T1084 2607-2609 IN denotes in
T1085 2610-2613 NN denotes Crx
T1086 2614-2618 VBP denotes have
T1087 2619-2623 VBN denotes been
T1088 2635-2639 IN denotes with
T1089 2640-2647 JJ denotes several
T1090 2654-2662 NNS denotes diseases
T1091 2648-2653 JJ denotes human
T1092 2663-2667 WDT denotes that
T1093 2668-2672 VBP denotes lead
T1094 2673-2675 IN denotes to
T1095 2676-2685 NN denotes blindness
T1096 2685-2687 , denotes ,
T1097 2687-2696 VBG denotes including
T1098 2697-2701 NN denotes cone
T1099 2702-2705 NN denotes rod
T1100 2701-2702 HYPH denotes -
T1101 2706-2715 NN denotes dystrophy
T1102 2716-2717 CD denotes 2
T1103 2718-2719 -LRB- denotes [
T1104 2724-2726 CD denotes 14
T1105 2719-2720 CD denotes 6
T1106 2720-2721 , denotes ,
T1107 2721-2723 CD denotes 13
T1108 2723-2724 , denotes ,
T1109 2726-2727 -RRB- denotes ]
T1110 2727-2729 , denotes ,
T1111 2729-2738 NN denotes retinitis
T1112 2739-2749 NN denotes pigmentosa
T1113 2750-2751 -LRB- denotes [
T1114 2751-2753 CD denotes 14
T1115 2753-2754 -RRB- denotes ]
T1116 2754-2756 , denotes ,
T1117 2756-2759 CC denotes and
T1118 2760-2763 NN denotes LCA
T1119 2764-2765 -LRB- denotes [
T1120 2765-2767 CD denotes 14
T1121 2767-2768 SYM denotes -
T1122 2768-2770 CD denotes 16
T1123 2770-2771 -RRB- denotes ]
T1124 2771-2772 . denotes .
T1125 2772-2908 sentence denotes Based on these data, Crx was hypothesized to play a critical role in the differentiation and maintainance of photoreceptor cells [5,7].
T1126 2773-2778 VBN denotes Based
T1127 2802-2814 VBN denotes hypothesized
T1128 2779-2781 IN denotes on
T1129 2782-2787 DT denotes these
T1130 2788-2792 NNS denotes data
T1131 2792-2794 , denotes ,
T1132 2794-2797 NN denotes Crx
T1133 2798-2801 VBD denotes was
T1134 2815-2817 TO denotes to
T1135 2818-2822 VB denotes play
T1136 2823-2824 DT denotes a
T1137 2834-2838 NN denotes role
T1138 2825-2833 JJ denotes critical
T1139 2839-2841 IN denotes in
T1140 2842-2845 DT denotes the
T1141 2846-2861 NN denotes differentiation
T1142 2862-2865 CC denotes and
T1143 2866-2878 NN denotes maintainance
T1144 2879-2881 IN denotes of
T1145 2882-2895 NN denotes photoreceptor
T1146 2896-2901 NNS denotes cells
T1147 2902-2903 -LRB- denotes [
T1148 2905-2906 CD denotes 7
T1149 2903-2904 CD denotes 5
T1150 2904-2905 , denotes ,
T1151 2906-2907 -RRB- denotes ]
T1152 2907-2908 . denotes .
T1153 2908-2996 sentence denotes LCA is the most severe genetic disease of photoreceptors (see [17], for recent review).
T1154 2909-2912 NN denotes LCA
T1155 2913-2915 VBZ denotes is
T1156 2916-2919 DT denotes the
T1157 2940-2947 NN denotes disease
T1158 2920-2924 RBS denotes most
T1159 2925-2931 JJ denotes severe
T1160 2932-2939 JJ denotes genetic
T1161 2948-2950 IN denotes of
T1162 2951-2965 NNS denotes photoreceptors
T1163 2966-2967 -LRB- denotes (
T1164 2967-2970 VB denotes see
T1165 2971-2972 -LRB- denotes [
T1166 2972-2974 CD denotes 17
T1167 2974-2975 -RRB- denotes ]
T1168 2975-2977 , denotes ,
T1169 2977-2980 IN denotes for
T1170 2981-2987 JJ denotes recent
T1171 2988-2994 NN denotes review
T1172 2994-2995 -RRB- denotes )
T1173 2995-2996 . denotes .
T1174 2996-3079 sentence denotes Affected infants exhibit a complete or near complete absence of vision from birth.
T1175 2997-3005 VBN denotes Affected
T1176 3006-3013 NNS denotes infants
T1177 3014-3021 VBP denotes exhibit
T1178 3022-3023 DT denotes a
T1179 3050-3057 NN denotes absence
T1180 3024-3032 JJ denotes complete
T1181 3033-3035 CC denotes or
T1182 3036-3040 RB denotes near
T1183 3041-3049 JJ denotes complete
T1184 3058-3060 IN denotes of
T1185 3061-3067 NN denotes vision
T1186 3068-3072 IN denotes from
T1187 3073-3078 NN denotes birth
T1188 3078-3079 . denotes .
T1189 3079-3248 sentence denotes Mutations in retinal specific genes, such as Crx, have been associated with LCA [14,15], as well as GUCY2D [18], RPE65 [19], AIPL-1 [20], CRB-1 [21], and RPGRIP-1 [22].
T1190 3080-3089 NNS denotes Mutations
T1191 3140-3150 VBN denotes associated
T1192 3090-3092 IN denotes in
T1193 3093-3100 NN denotes retinal
T1194 3101-3109 JJ denotes specific
T1195 3110-3115 NNS denotes genes
T1196 3115-3117 , denotes ,
T1197 3117-3121 JJ denotes such
T1198 3122-3124 IN denotes as
T1199 3125-3128 NN denotes Crx
T1200 3128-3130 , denotes ,
T1201 3130-3134 VBP denotes have
T1202 3135-3139 VBN denotes been
T1203 3151-3155 IN denotes with
T1204 3156-3159 NN denotes LCA
T1205 3160-3161 -LRB- denotes [
T1206 3164-3166 CD denotes 15
T1207 3161-3163 CD denotes 14
T1208 3163-3164 , denotes ,
T1209 3166-3167 -RRB- denotes ]
T1210 3167-3169 , denotes ,
T1211 3169-3171 RB denotes as
T1212 3177-3179 IN denotes as
T1213 3172-3176 RB denotes well
T1214 3180-3186 NN denotes GUCY2D
T1215 3187-3188 -LRB- denotes [
T1216 3188-3190 CD denotes 18
T1217 3190-3191 -RRB- denotes ]
T1218 3191-3193 , denotes ,
T1219 3193-3198 NN denotes RPE65
T1220 3199-3200 -LRB- denotes [
T1221 3200-3202 CD denotes 19
T1222 3202-3203 -RRB- denotes ]
T1223 3203-3205 , denotes ,
T1224 3205-3209 NN denotes AIPL
T1225 3209-3210 HYPH denotes -
T1226 3210-3211 CD denotes 1
T1227 3212-3213 -LRB- denotes [
T1228 3213-3215 CD denotes 20
T1229 3215-3216 -RRB- denotes ]
T1230 3216-3218 , denotes ,
T1231 3218-3221 NN denotes CRB
T1232 3221-3222 HYPH denotes -
T1233 3222-3223 CD denotes 1
T1234 3224-3225 -LRB- denotes [
T1235 3225-3227 CD denotes 21
T1236 3227-3228 -RRB- denotes ]
T1237 3228-3230 , denotes ,
T1238 3230-3233 CC denotes and
T1239 3234-3240 NN denotes RPGRIP
T1240 3240-3241 HYPH denotes -
T1241 3241-3242 CD denotes 1
T1242 3243-3244 -LRB- denotes [
T1243 3244-3246 CD denotes 22
T1244 3246-3247 -RRB- denotes ]
T1245 3247-3248 . denotes .
T1246 3248-3361 sentence denotes There also may be as many as three additional genetically linked loci where genes have not been identified [23].
T1247 3249-3254 EX denotes There
T1248 3264-3266 VB denotes be
T1249 3255-3259 RB denotes also
T1250 3260-3263 MD denotes may
T1251 3267-3269 RB denotes as
T1252 3278-3283 CD denotes three
T1253 3270-3274 JJ denotes many
T1254 3275-3277 IN denotes as
T1255 3314-3318 NNS denotes loci
T1256 3284-3294 JJ denotes additional
T1257 3295-3306 RB denotes genetically
T1258 3307-3313 VBN denotes linked
T1259 3319-3324 WRB denotes where
T1260 3345-3355 VBN denotes identified
T1261 3325-3330 NNS denotes genes
T1262 3331-3335 VBP denotes have
T1263 3336-3339 RB denotes not
T1264 3340-3344 VBN denotes been
T1265 3356-3357 -LRB- denotes [
T1266 3357-3359 CD denotes 23
T1267 3359-3360 -RRB- denotes ]
T1268 3360-3361 . denotes .
T1269 3361-3503 sentence denotes Crx mutations in LCA are varied, and include a putative dominant mutation that is proposed to encode a dominant-negative form of Crx [14,15].
T1270 3362-3365 NN denotes Crx
T1271 3366-3375 NNS denotes mutations
T1272 3383-3386 VBP denotes are
T1273 3376-3378 IN denotes in
T1274 3379-3382 NN denotes LCA
T1275 3387-3393 JJ denotes varied
T1276 3393-3395 , denotes ,
T1277 3395-3398 CC denotes and
T1278 3399-3406 VBP denotes include
T1279 3407-3408 DT denotes a
T1280 3427-3435 NN denotes mutation
T1281 3409-3417 JJ denotes putative
T1282 3418-3426 JJ denotes dominant
T1283 3436-3440 WDT denotes that
T1284 3444-3452 VBN denotes proposed
T1285 3441-3443 VBZ denotes is
T1286 3453-3455 TO denotes to
T1287 3456-3462 VB denotes encode
T1288 3463-3464 DT denotes a
T1289 3483-3487 NN denotes form
T1290 3465-3473 JJ denotes dominant
T1291 3474-3482 JJ denotes negative
T1292 3473-3474 HYPH denotes -
T1293 3488-3490 IN denotes of
T1294 3491-3494 NN denotes Crx
T1295 3495-3496 -LRB- denotes [
T1296 3499-3501 CD denotes 15
T1297 3496-3498 CD denotes 14
T1298 3498-3499 , denotes ,
T1299 3501-3502 -RRB- denotes ]
T1300 3502-3503 . denotes .
T1301 3503-3631 sentence denotes Recessive mutations also have been reported and at least one allele encodes a protein with decreased DNA-binding activity [16].
T1302 3504-3513 JJ denotes Recessive
T1303 3514-3523 NNS denotes mutations
T1304 3539-3547 VBN denotes reported
T1305 3524-3528 RB denotes also
T1306 3529-3533 VBP denotes have
T1307 3534-3538 VBN denotes been
T1308 3548-3551 CC denotes and
T1309 3552-3554 RB denotes at
T1310 3561-3564 CD denotes one
T1311 3555-3560 RBS denotes least
T1312 3565-3571 NN denotes allele
T1313 3572-3579 VBZ denotes encodes
T1314 3580-3581 DT denotes a
T1315 3582-3589 NN denotes protein
T1316 3590-3594 IN denotes with
T1317 3595-3604 VBN denotes decreased
T1318 3617-3625 NN denotes activity
T1319 3605-3608 NN denotes DNA
T1320 3608-3609 HYPH denotes -
T1321 3609-3616 VBG denotes binding
T1322 3626-3627 -LRB- denotes [
T1323 3627-3629 CD denotes 16
T1324 3629-3630 -RRB- denotes ]
T1325 3630-3631 . denotes .
T1326 3631-3783 sentence denotes Histopathological and ultrastructural studies of LCA should enable a better understanding of the disease process, and the design of suitable therapies.
T1327 3632-3649 JJ denotes Histopathological
T1328 3670-3677 NNS denotes studies
T1329 3650-3653 CC denotes and
T1330 3654-3669 JJ denotes ultrastructural
T1331 3692-3698 VB denotes enable
T1332 3678-3680 IN denotes of
T1333 3681-3684 NN denotes LCA
T1334 3685-3691 MD denotes should
T1335 3699-3700 DT denotes a
T1336 3708-3721 NN denotes understanding
T1337 3701-3707 JJR denotes better
T1338 3722-3724 IN denotes of
T1339 3725-3728 DT denotes the
T1340 3737-3744 NN denotes process
T1341 3729-3736 NN denotes disease
T1342 3744-3746 , denotes ,
T1343 3746-3749 CC denotes and
T1344 3750-3753 DT denotes the
T1345 3754-3760 NN denotes design
T1346 3761-3763 IN denotes of
T1347 3764-3772 JJ denotes suitable
T1348 3773-3782 NNS denotes therapies
T1349 3782-3783 . denotes .
T1350 3783-3961 sentence denotes Few such studies exist for human LCA (reviewed in [17]) and the majority of such studies examine the globes of adults with LCA, after the tissue has undergone secondary changes.
T1351 3784-3787 JJ denotes Few
T1352 3793-3800 NNS denotes studies
T1353 3788-3792 JJ denotes such
T1354 3801-3806 VBP denotes exist
T1355 3807-3810 IN denotes for
T1356 3811-3816 JJ denotes human
T1357 3817-3820 NN denotes LCA
T1358 3821-3822 -LRB- denotes (
T1359 3822-3830 VBN denotes reviewed
T1360 3831-3833 IN denotes in
T1361 3834-3835 -LRB- denotes [
T1362 3835-3837 CD denotes 17
T1363 3837-3838 -RRB- denotes ]
T1364 3838-3839 -RRB- denotes )
T1365 3840-3843 CC denotes and
T1366 3844-3847 DT denotes the
T1367 3848-3856 NN denotes majority
T1368 3873-3880 VBP denotes examine
T1369 3857-3859 IN denotes of
T1370 3860-3864 JJ denotes such
T1371 3865-3872 NNS denotes studies
T1372 3881-3884 DT denotes the
T1373 3885-3891 NNS denotes globes
T1374 3892-3894 IN denotes of
T1375 3895-3901 NNS denotes adults
T1376 3902-3906 IN denotes with
T1377 3907-3910 NN denotes LCA
T1378 3910-3912 , denotes ,
T1379 3912-3917 IN denotes after
T1380 3933-3942 VBN denotes undergone
T1381 3918-3921 DT denotes the
T1382 3922-3928 NN denotes tissue
T1383 3929-3932 VBZ denotes has
T1384 3943-3952 JJ denotes secondary
T1385 3953-3960 NNS denotes changes
T1386 3960-3961 . denotes .
T1387 3961-4045 sentence denotes Only a single study exists where the developing eye of an infant was examined [24].
T1388 3962-3966 RB denotes Only
T1389 3976-3981 NN denotes study
T1390 3967-3968 DT denotes a
T1391 3969-3975 JJ denotes single
T1392 3982-3988 VBZ denotes exists
T1393 3989-3994 WRB denotes where
T1394 4031-4039 VBN denotes examined
T1395 3995-3998 DT denotes the
T1396 4010-4013 NN denotes eye
T1397 3999-4009 VBG denotes developing
T1398 4014-4016 IN denotes of
T1399 4017-4019 DT denotes an
T1400 4020-4026 NN denotes infant
T1401 4027-4030 VBD denotes was
T1402 4040-4041 -LRB- denotes [
T1403 4041-4043 CD denotes 24
T1404 4043-4044 -RRB- denotes ]
T1405 4044-4045 . denotes .
T1406 4045-4190 sentence denotes Animal models for LCA have recently been reported and have already served to broaden our understanding of the pathology of this disease [25-28].
T1407 4046-4052 NN denotes Animal
T1408 4053-4059 NNS denotes models
T1409 4087-4095 VBN denotes reported
T1410 4060-4063 IN denotes for
T1411 4064-4067 NN denotes LCA
T1412 4068-4072 VBP denotes have
T1413 4073-4081 RB denotes recently
T1414 4082-4086 VBN denotes been
T1415 4096-4099 CC denotes and
T1416 4100-4104 VBP denotes have
T1417 4113-4119 VBN denotes served
T1418 4105-4112 RB denotes already
T1419 4120-4122 TO denotes to
T1420 4123-4130 VB denotes broaden
T1421 4131-4134 PRP$ denotes our
T1422 4135-4148 NN denotes understanding
T1423 4149-4151 IN denotes of
T1424 4152-4155 DT denotes the
T1425 4156-4165 NN denotes pathology
T1426 4166-4168 IN denotes of
T1427 4169-4173 DT denotes this
T1428 4174-4181 NN denotes disease
T1429 4182-4183 -LRB- denotes [
T1430 4183-4185 CD denotes 25
T1431 4185-4186 SYM denotes -
T1432 4186-4188 CD denotes 28
T1433 4188-4189 -RRB- denotes ]
T1434 4189-4190 . denotes .
T1435 4190-4388 sentence denotes Since LCA is a clinically and genetically heterogeneous disorder, additional mouse models are in order to allow a full understanding of the many ways in which photoreceptor development can go awry.
T1436 4191-4196 IN denotes Since
T1437 4201-4203 VBZ denotes is
T1438 4197-4200 NN denotes LCA
T1439 4281-4284 VBP denotes are
T1440 4204-4205 DT denotes a
T1441 4247-4255 NN denotes disorder
T1442 4206-4216 RB denotes clinically
T1443 4233-4246 JJ denotes heterogeneous
T1444 4217-4220 CC denotes and
T1445 4221-4232 RB denotes genetically
T1446 4255-4257 , denotes ,
T1447 4257-4267 JJ denotes additional
T1448 4274-4280 NNS denotes models
T1449 4268-4273 NN denotes mouse
T1450 4285-4287 IN denotes in
T1451 4288-4293 NN denotes order
T1452 4294-4296 TO denotes to
T1453 4297-4302 VB denotes allow
T1454 4303-4304 DT denotes a
T1455 4310-4323 NN denotes understanding
T1456 4305-4309 JJ denotes full
T1457 4324-4326 IN denotes of
T1458 4327-4330 DT denotes the
T1459 4336-4340 NNS denotes ways
T1460 4331-4335 JJ denotes many
T1461 4341-4343 IN denotes in
T1462 4380-4382 VB denotes go
T1463 4344-4349 WDT denotes which
T1464 4350-4363 NN denotes photoreceptor
T1465 4364-4375 NN denotes development
T1466 4376-4379 MD denotes can
T1467 4383-4387 JJ denotes awry
T1468 4387-4388 . denotes .
T1469 4388-4532 sentence denotes In addition to their importance as a locus of disease, photoreceptor cells serve as an excellent model for studies in neuronal differentiation.
T1470 4389-4391 IN denotes In
T1471 4464-4469 VBP denotes serve
T1472 4392-4400 NN denotes addition
T1473 4401-4403 IN denotes to
T1474 4404-4409 PRP$ denotes their
T1475 4410-4420 NN denotes importance
T1476 4421-4423 IN denotes as
T1477 4424-4425 DT denotes a
T1478 4426-4431 NN denotes locus
T1479 4432-4434 IN denotes of
T1480 4435-4442 NN denotes disease
T1481 4442-4444 , denotes ,
T1482 4444-4457 NN denotes photoreceptor
T1483 4458-4463 NNS denotes cells
T1484 4470-4472 IN denotes as
T1485 4473-4475 DT denotes an
T1486 4486-4491 NN denotes model
T1487 4476-4485 JJ denotes excellent
T1488 4492-4495 IN denotes for
T1489 4496-4503 NNS denotes studies
T1490 4504-4506 IN denotes in
T1491 4507-4515 JJ denotes neuronal
T1492 4516-4531 NN denotes differentiation
T1493 4531-4532 . denotes .
T1494 4532-4574 sentence denotes Photoreceptor cells are highly polarized.
T1495 4533-4546 NN denotes Photoreceptor
T1496 4547-4552 NNS denotes cells
T1497 4553-4556 VBP denotes are
T1498 4557-4563 RB denotes highly
T1499 4564-4573 JJ denotes polarized
T1500 4573-4574 . denotes .
T1501 4574-4703 sentence denotes At their apex, these neurons have a membranous outer segment, which contains proteins involved in the phototransduction cascade.
T1502 4575-4577 IN denotes At
T1503 4604-4608 VBP denotes have
T1504 4578-4583 PRP$ denotes their
T1505 4584-4588 NN denotes apex
T1506 4588-4590 , denotes ,
T1507 4590-4595 DT denotes these
T1508 4596-4603 NNS denotes neurons
T1509 4609-4610 DT denotes a
T1510 4628-4635 NN denotes segment
T1511 4611-4621 JJ denotes membranous
T1512 4622-4627 JJ denotes outer
T1513 4635-4637 , denotes ,
T1514 4637-4642 WDT denotes which
T1515 4643-4651 VBZ denotes contains
T1516 4652-4660 NN denotes proteins
T1517 4661-4669 VBN denotes involved
T1518 4670-4672 IN denotes in
T1519 4673-4676 DT denotes the
T1520 4695-4702 NN denotes cascade
T1521 4677-4694 NN denotes phototransduction
T1522 4702-4703 . denotes .
T1523 4703-4840 sentence denotes Loss of function mutations in rhodopsin [29], or the structural protein, peripherin [30], result in an inability to form outer segments.
T1524 4704-4708 NN denotes Loss
T1525 4721-4730 NNS denotes mutations
T1526 4709-4711 IN denotes of
T1527 4712-4720 NN denotes function
T1528 4794-4800 VBP denotes result
T1529 4731-4733 IN denotes in
T1530 4734-4743 NN denotes rhodopsin
T1531 4744-4745 -LRB- denotes [
T1532 4745-4747 CD denotes 29
T1533 4747-4748 -RRB- denotes ]
T1534 4748-4750 , denotes ,
T1535 4750-4752 CC denotes or
T1536 4753-4756 DT denotes the
T1537 4768-4775 NN denotes protein
T1538 4757-4767 JJ denotes structural
T1539 4775-4777 , denotes ,
T1540 4777-4787 NN denotes peripherin
T1541 4788-4789 -LRB- denotes [
T1542 4789-4791 CD denotes 30
T1543 4791-4792 -RRB- denotes ]
T1544 4792-4794 , denotes ,
T1545 4801-4803 IN denotes in
T1546 4804-4806 DT denotes an
T1547 4807-4816 NN denotes inability
T1548 4817-4819 TO denotes to
T1549 4820-4824 VB denotes form
T1550 4825-4830 JJ denotes outer
T1551 4831-4839 NNS denotes segments
T1552 4839-4840 . denotes .
T1553 4840-4989 sentence denotes At the other extremity, photoreceptors terminate with synaptic endings that make contact with the processes of horizontal and bipolar cells [31,32].
T1554 4841-4843 IN denotes At
T1555 4880-4889 VBP denotes terminate
T1556 4844-4847 DT denotes the
T1557 4854-4863 NN denotes extremity
T1558 4848-4853 JJ denotes other
T1559 4863-4865 , denotes ,
T1560 4865-4879 NNS denotes photoreceptors
T1561 4890-4894 IN denotes with
T1562 4895-4903 JJ denotes synaptic
T1563 4904-4911 NNS denotes endings
T1564 4912-4916 WDT denotes that
T1565 4917-4921 VBP denotes make
T1566 4922-4929 NN denotes contact
T1567 4930-4934 IN denotes with
T1568 4935-4938 DT denotes the
T1569 4939-4948 NNS denotes processes
T1570 4949-4951 IN denotes of
T1571 4952-4962 JJ denotes horizontal
T1572 4975-4980 NNS denotes cells
T1573 4963-4966 CC denotes and
T1574 4967-4974 JJ denotes bipolar
T1575 4981-4982 -LRB- denotes [
T1576 4985-4987 CD denotes 32
T1577 4982-4984 CD denotes 31
T1578 4984-4985 , denotes ,
T1579 4987-4988 -RRB- denotes ]
T1580 4988-4989 . denotes .
T1581 4989-5104 sentence denotes Rod spherules establish an invaginating synapse with rod bipolar dendrites and axonal endings of horizontal cells.
T1582 4990-4993 NN denotes Rod
T1583 4994-5003 NNS denotes spherules
T1584 5004-5013 VBP denotes establish
T1585 5014-5016 DT denotes an
T1586 5030-5037 NN denotes synapse
T1587 5017-5029 VBG denotes invaginating
T1588 5038-5042 IN denotes with
T1589 5043-5046 NN denotes rod
T1590 5055-5064 NNS denotes dendrites
T1591 5047-5054 JJ denotes bipolar
T1592 5065-5068 CC denotes and
T1593 5069-5075 JJ denotes axonal
T1594 5076-5083 NNS denotes endings
T1595 5084-5086 IN denotes of
T1596 5087-5097 JJ denotes horizontal
T1597 5098-5103 NNS denotes cells
T1598 5103-5104 . denotes .
T1599 5104-5192 sentence denotes This synapse is characterized by the presence of a ribbon in the presynaptic cytoplasm.
T1600 5105-5109 DT denotes This
T1601 5110-5117 NN denotes synapse
T1602 5121-5134 VBN denotes characterized
T1603 5118-5120 VBZ denotes is
T1604 5135-5137 IN denotes by
T1605 5138-5141 DT denotes the
T1606 5142-5150 NN denotes presence
T1607 5151-5153 IN denotes of
T1608 5154-5155 DT denotes a
T1609 5156-5162 NN denotes ribbon
T1610 5163-5165 IN denotes in
T1611 5166-5169 DT denotes the
T1612 5182-5191 NN denotes cytoplasm
T1613 5170-5181 JJ denotes presynaptic
T1614 5191-5192 . denotes .
T1615 5192-5364 sentence denotes Cone pedicles make invaginating synapses with the dendrites of on-cone bipolar cells and horizontal cells and basal junctions with the dendrites of off-cone bipolar cells.
T1616 5193-5197 NN denotes Cone
T1617 5198-5206 NNS denotes pedicles
T1618 5207-5211 VBP denotes make
T1619 5212-5224 VBG denotes invaginating
T1620 5225-5233 NNS denotes synapses
T1621 5234-5238 IN denotes with
T1622 5239-5242 DT denotes the
T1623 5243-5252 NNS denotes dendrites
T1624 5253-5255 IN denotes of
T1625 5256-5258 IN denotes on
T1626 5272-5277 NNS denotes cells
T1627 5258-5259 HYPH denotes -
T1628 5259-5263 NN denotes cone
T1629 5264-5271 JJ denotes bipolar
T1630 5278-5281 CC denotes and
T1631 5282-5292 JJ denotes horizontal
T1632 5293-5298 NNS denotes cells
T1633 5299-5302 CC denotes and
T1634 5303-5308 JJ denotes basal
T1635 5309-5318 NNS denotes junctions
T1636 5319-5323 IN denotes with
T1637 5324-5327 DT denotes the
T1638 5328-5337 NNS denotes dendrites
T1639 5338-5340 IN denotes of
T1640 5341-5344 IN denotes off
T1641 5358-5363 NNS denotes cells
T1642 5344-5345 HYPH denotes -
T1643 5345-5349 NN denotes cone
T1644 5350-5357 JJ denotes bipolar
T1645 5363-5364 . denotes .
T1646 5364-5455 sentence denotes The factors regulating the formation of the photoreceptor synapses are completely unknown.
T1647 5365-5368 DT denotes The
T1648 5369-5376 NNS denotes factors
T1649 5432-5435 VBP denotes are
T1650 5377-5387 VBG denotes regulating
T1651 5388-5391 DT denotes the
T1652 5392-5401 NN denotes formation
T1653 5402-5404 IN denotes of
T1654 5405-5408 DT denotes the
T1655 5423-5431 NNS denotes synapses
T1656 5409-5422 NN denotes photoreceptor
T1657 5436-5446 RB denotes completely
T1658 5447-5454 JJ denotes unknown
T1659 5454-5455 . denotes .
T1660 5455-5596 sentence denotes At least one photoreceptor synaptic protein, HRG4, contains a potential Crx target sequence in its transcriptional regulatory sequence [33].
T1661 5456-5458 RB denotes At
T1662 5465-5468 CD denotes one
T1663 5459-5464 RBS denotes least
T1664 5492-5499 NN denotes protein
T1665 5469-5482 NN denotes photoreceptor
T1666 5483-5491 JJ denotes synaptic
T1667 5507-5515 VBZ denotes contains
T1668 5499-5501 , denotes ,
T1669 5501-5505 NN denotes HRG4
T1670 5505-5507 , denotes ,
T1671 5516-5517 DT denotes a
T1672 5539-5547 NN denotes sequence
T1673 5518-5527 JJ denotes potential
T1674 5528-5531 NN denotes Crx
T1675 5532-5538 NN denotes target
T1676 5548-5550 IN denotes in
T1677 5551-5554 PRP$ denotes its
T1678 5582-5590 NN denotes sequence
T1679 5555-5570 JJ denotes transcriptional
T1680 5571-5581 JJ denotes regulatory
T1681 5591-5592 -LRB- denotes [
T1682 5592-5594 CD denotes 33
T1683 5594-5595 -RRB- denotes ]
T1684 5595-5596 . denotes .
T1685 5596-5712 sentence denotes Few studies of LCA animal models have extended their examination of retinal pathology to the ultrastructural level.
T1686 5597-5600 JJ denotes Few
T1687 5601-5608 NNS denotes studies
T1688 5635-5643 VBN denotes extended
T1689 5609-5611 IN denotes of
T1690 5612-5615 NN denotes LCA
T1691 5623-5629 NNS denotes models
T1692 5616-5622 NN denotes animal
T1693 5630-5634 VBP denotes have
T1694 5644-5649 PRP$ denotes their
T1695 5650-5661 NN denotes examination
T1696 5662-5664 IN denotes of
T1697 5665-5672 JJ denotes retinal
T1698 5673-5682 NN denotes pathology
T1699 5683-5685 IN denotes to
T1700 5686-5689 DT denotes the
T1701 5706-5711 NN denotes level
T1702 5690-5705 JJ denotes ultrastructural
T1703 5711-5712 . denotes .
T1704 5712-5841 sentence denotes Certain features of neuronal differentiation, such as synapse formation, can be detected definitively at this level of analysis.
T1705 5713-5720 JJ denotes Certain
T1706 5721-5729 NNS denotes features
T1707 5793-5801 VBN denotes detected
T1708 5730-5732 IN denotes of
T1709 5733-5741 JJ denotes neuronal
T1710 5742-5757 NN denotes differentiation
T1711 5757-5759 , denotes ,
T1712 5759-5763 JJ denotes such
T1713 5764-5766 IN denotes as
T1714 5767-5774 NN denotes synapse
T1715 5775-5784 NN denotes formation
T1716 5784-5786 , denotes ,
T1717 5786-5789 MD denotes can
T1718 5790-5792 VB denotes be
T1719 5802-5814 RB denotes definitively
T1720 5815-5817 IN denotes at
T1721 5818-5822 DT denotes this
T1722 5823-5828 NN denotes level
T1723 5829-5831 IN denotes of
T1724 5832-5840 NN denotes analysis
T1725 5840-5841 . denotes .
T1726 5841-6019 sentence denotes With the hope of understanding the neuropathology of LCA in greater detail, we have analyzed the differentiation of the outer retina in Crx-/- mice at the ultrastructural level.
T1727 5842-5846 IN denotes With
T1728 5926-5934 VBN denotes analyzed
T1729 5847-5850 DT denotes the
T1730 5851-5855 NN denotes hope
T1731 5856-5858 IN denotes of
T1732 5859-5872 VBG denotes understanding
T1733 5873-5876 DT denotes the
T1734 5877-5891 NN denotes neuropathology
T1735 5892-5894 IN denotes of
T1736 5895-5898 NN denotes LCA
T1737 5899-5901 IN denotes in
T1738 5902-5909 JJR denotes greater
T1739 5910-5916 NN denotes detail
T1740 5916-5918 , denotes ,
T1741 5918-5920 PRP denotes we
T1742 5921-5925 VBP denotes have
T1743 5935-5938 DT denotes the
T1744 5939-5954 NN denotes differentiation
T1745 5955-5957 IN denotes of
T1746 5958-5961 DT denotes the
T1747 5968-5974 NN denotes retina
T1748 5962-5967 JJ denotes outer
T1749 5975-5977 IN denotes in
T1750 5978-5981 NN denotes Crx
T1751 5985-5989 NNS denotes mice
T1752 5981-5982 SYM denotes -
T1753 5982-5983 HYPH denotes /
T1754 5983-5984 SYM denotes -
T1755 5990-5992 IN denotes at
T1756 5993-5996 DT denotes the
T1757 6013-6018 NN denotes level
T1758 5997-6012 JJ denotes ultrastructural
T1759 6018-6019 . denotes .
T1760 6019-6068 sentence denotes These retinas exhibit several prominent defects.
T1761 6020-6025 DT denotes These
T1762 6026-6033 NNS denotes retinas
T1763 6034-6041 VBP denotes exhibit
T1764 6042-6049 JJ denotes several
T1765 6060-6067 NNS denotes defects
T1766 6050-6059 JJ denotes prominent
T1767 6067-6068 . denotes .
T1768 6068-6171 sentence denotes Crx-/- photoreceptors demonstrate a complete block in outer segment formation at the elongation stage.
T1769 6069-6072 NN denotes Crx
T1770 6076-6090 NNS denotes photoreceptors
T1771 6072-6073 SYM denotes -
T1772 6073-6074 HYPH denotes /
T1773 6074-6075 SYM denotes -
T1774 6091-6102 VBP denotes demonstrate
T1775 6103-6104 DT denotes a
T1776 6114-6119 NN denotes block
T1777 6105-6113 JJ denotes complete
T1778 6120-6122 IN denotes in
T1779 6123-6128 JJ denotes outer
T1780 6129-6136 NN denotes segment
T1781 6137-6146 NN denotes formation
T1782 6147-6149 IN denotes at
T1783 6150-6153 DT denotes the
T1784 6165-6170 NN denotes stage
T1785 6154-6164 NN denotes elongation
T1786 6170-6171 . denotes .
T1787 6171-6302 sentence denotes Further, these cells exhibit abnormal synaptic morphology, thereby broadening the function of Crx to photoreceptor synaptogenesis.
T1788 6172-6179 RB denotes Further
T1789 6193-6200 VBP denotes exhibit
T1790 6179-6181 , denotes ,
T1791 6181-6186 DT denotes these
T1792 6187-6192 NNS denotes cells
T1793 6201-6209 JJ denotes abnormal
T1794 6219-6229 NN denotes morphology
T1795 6210-6218 JJ denotes synaptic
T1796 6229-6231 , denotes ,
T1797 6231-6238 RB denotes thereby
T1798 6239-6249 VBG denotes broadening
T1799 6250-6253 DT denotes the
T1800 6254-6262 NN denotes function
T1801 6263-6265 IN denotes of
T1802 6266-6269 NN denotes Crx
T1803 6270-6272 IN denotes to
T1804 6273-6286 NN denotes photoreceptor
T1805 6287-6301 NN denotes synaptogenesis
T1806 6301-6302 . denotes .
T1807 6302-6397 sentence denotes This represents the first report strongly implicating the process of synapse formation in LCA.
T1808 6303-6307 DT denotes This
T1809 6308-6318 VBZ denotes represents
T1810 6319-6322 DT denotes the
T1811 6329-6335 NN denotes report
T1812 6323-6328 JJ denotes first
T1813 6336-6344 RB denotes strongly
T1814 6345-6356 VBG denotes implicating
T1815 6357-6360 DT denotes the
T1816 6361-6368 NN denotes process
T1817 6369-6371 IN denotes of
T1818 6372-6379 NN denotes synapse
T1819 6380-6389 NN denotes formation
T1820 6390-6392 IN denotes in
T1821 6393-6396 NN denotes LCA
T1822 6396-6397 . denotes .
T2359 6408-6416 JJ denotes Multiple
T2360 6417-6428 NNS denotes pathologies
T2361 6429-6431 IN denotes in
T2362 6432-6435 DT denotes the
T2363 6450-6455 NN denotes layer
T2364 6436-6441 JJ denotes outer
T2365 6442-6449 NN denotes segment
T2366 6456-6458 IN denotes in
T2367 6459-6462 NN denotes Crx
T2368 6466-6470 NNS denotes mice
T2369 6462-6463 SYM denotes -
T2370 6463-6464 HYPH denotes /
T2371 6464-6465 SYM denotes -
T2372 6470-6587 sentence denotes A standard knock-out protocol was used to generate mice in which the homeodomain of Crx-/- was targeted and deleted.
T2373 6471-6472 DT denotes A
T2374 6492-6500 NN denotes protocol
T2375 6473-6481 JJ denotes standard
T2376 6482-6487 VB denotes knock
T2377 6487-6488 HYPH denotes -
T2378 6488-6491 RP denotes out
T2379 6505-6509 VBN denotes used
T2380 6501-6504 VBD denotes was
T2381 6510-6512 TO denotes to
T2382 6513-6521 VB denotes generate
T2383 6522-6526 NNS denotes mice
T2384 6527-6529 IN denotes in
T2385 6566-6574 VBN denotes targeted
T2386 6530-6535 WDT denotes which
T2387 6536-6539 DT denotes the
T2388 6540-6551 NN denotes homeodomain
T2389 6552-6554 IN denotes of
T2390 6555-6558 NN denotes Crx
T2391 6558-6559 SYM denotes -
T2392 6559-6560 HYPH denotes /
T2393 6560-6561 SYM denotes -
T2394 6562-6565 VBD denotes was
T2395 6575-6578 CC denotes and
T2396 6579-6586 VBN denotes deleted
T2397 6586-6587 . denotes .
T2398 6587-6653 sentence denotes Generation of these Crx-/- mice has been reported elsewhere [34].
T2399 6588-6598 NN denotes Generation
T2400 6629-6637 VBN denotes reported
T2401 6599-6601 IN denotes of
T2402 6602-6607 DT denotes these
T2403 6615-6619 NNS denotes mice
T2404 6608-6611 NN denotes Crx
T2405 6611-6612 SYM denotes -
T2406 6612-6613 HYPH denotes /
T2407 6613-6614 SYM denotes -
T2408 6620-6623 VBZ denotes has
T2409 6624-6628 VBN denotes been
T2410 6638-6647 RB denotes elsewhere
T2411 6648-6649 -LRB- denotes [
T2412 6649-6651 CD denotes 34
T2413 6651-6652 -RRB- denotes ]
T2414 6652-6653 . denotes .
T2415 6653-6838 sentence denotes In this study, in order to characterize further the role of Crx in photoreceptor morphogenesis, the outer retinae from Crx-/- mice were examined using transmission electron microscopy.
T2416 6654-6656 IN denotes In
T2417 6790-6798 VBN denotes examined
T2418 6657-6661 DT denotes this
T2419 6662-6667 NN denotes study
T2420 6667-6669 , denotes ,
T2421 6669-6671 IN denotes in
T2422 6672-6677 NN denotes order
T2423 6678-6680 TO denotes to
T2424 6681-6693 VB denotes characterize
T2425 6694-6701 RB denotes further
T2426 6702-6705 DT denotes the
T2427 6706-6710 NN denotes role
T2428 6711-6713 IN denotes of
T2429 6714-6717 NN denotes Crx
T2430 6718-6720 IN denotes in
T2431 6721-6734 NN denotes photoreceptor
T2432 6735-6748 NN denotes morphogenesis
T2433 6748-6750 , denotes ,
T2434 6750-6753 DT denotes the
T2435 6760-6767 NNS denotes retinae
T2436 6754-6759 JJ denotes outer
T2437 6768-6772 IN denotes from
T2438 6773-6776 NN denotes Crx
T2439 6780-6784 NNS denotes mice
T2440 6776-6777 SYM denotes -
T2441 6777-6778 HYPH denotes /
T2442 6778-6779 SYM denotes -
T2443 6785-6789 VBD denotes were
T2444 6799-6804 VBG denotes using
T2445 6805-6817 NN denotes transmission
T2446 6827-6837 NN denotes microscopy
T2447 6818-6826 NN denotes electron
T2448 6837-6838 . denotes .
T2449 6838-7017 sentence denotes At postnatal day 21 (P21), when Crx+/+ photoreceptors exhibited robust outer segments (Figure 1A, os), Crx-/- retinas were without a recognizable outer segment layer (Figure 1B).
T2450 6839-6841 IN denotes At
T2451 6957-6961 VBD denotes were
T2452 6842-6851 JJ denotes postnatal
T2453 6852-6855 NN denotes day
T2454 6856-6858 CD denotes 21
T2455 6859-6860 -LRB- denotes (
T2456 6860-6863 NN denotes P21
T2457 6863-6864 -RRB- denotes )
T2458 6864-6866 , denotes ,
T2459 6866-6870 WRB denotes when
T2460 6893-6902 VBD denotes exhibited
T2461 6871-6874 NN denotes Crx
T2462 6878-6892 NNS denotes photoreceptors
T2463 6874-6875 SYM denotes +
T2464 6875-6876 HYPH denotes /
T2465 6876-6877 SYM denotes +
T2466 6903-6909 JJ denotes robust
T2467 6916-6924 NNS denotes segments
T2468 6910-6915 JJ denotes outer
T2469 6925-6926 -LRB- denotes (
T2470 6937-6939 NN denotes os
T2471 6926-6932 NN denotes Figure
T2472 6933-6935 NN denotes 1A
T2473 6935-6937 , denotes ,
T2474 6939-6940 -RRB- denotes )
T2475 6940-6942 , denotes ,
T2476 6942-6945 NN denotes Crx
T2477 6949-6956 NNS denotes retinas
T2478 6945-6946 SYM denotes -
T2479 6946-6947 HYPH denotes /
T2480 6947-6948 SYM denotes -
T2481 6962-6969 IN denotes without
T2482 6970-6971 DT denotes a
T2483 6999-7004 NN denotes layer
T2484 6972-6984 JJ denotes recognizable
T2485 6985-6990 JJ denotes outer
T2486 6991-6998 NN denotes segment
T2487 7005-7006 -LRB- denotes (
T2488 7006-7012 NN denotes Figure
T2489 7013-7015 CD denotes 1B
T2490 7015-7016 -RRB- denotes )
T2491 7016-7017 . denotes .
T2492 7017-7192 sentence denotes Crx-/- photoreceptors had inner segments, demonstrating at least limited photoreceptor polarization in the Crx mutant, but the inner segments were extremely short (Figure 2).
T2493 7018-7021 NN denotes Crx
T2494 7025-7039 NNS denotes photoreceptors
T2495 7021-7022 SYM denotes -
T2496 7022-7023 HYPH denotes /
T2497 7023-7024 SYM denotes -
T2498 7040-7043 VBD denotes had
T2499 7044-7049 JJ denotes inner
T2500 7050-7058 NNS denotes segments
T2501 7058-7060 , denotes ,
T2502 7060-7073 VBG denotes demonstrating
T2503 7074-7076 RB denotes at
T2504 7077-7082 RBS denotes least
T2505 7083-7090 JJ denotes limited
T2506 7105-7117 NN denotes polarization
T2507 7091-7104 NN denotes photoreceptor
T2508 7118-7120 IN denotes in
T2509 7121-7124 DT denotes the
T2510 7129-7135 NN denotes mutant
T2511 7125-7128 NN denotes Crx
T2512 7135-7137 , denotes ,
T2513 7137-7140 CC denotes but
T2514 7141-7144 DT denotes the
T2515 7151-7159 NNS denotes segments
T2516 7145-7150 JJ denotes inner
T2517 7160-7164 VBD denotes were
T2518 7165-7174 RB denotes extremely
T2519 7175-7180 JJ denotes short
T2520 7181-7182 -LRB- denotes (
T2521 7182-7188 NN denotes Figure
T2522 7189-7190 CD denotes 2
T2523 7190-7191 -RRB- denotes )
T2524 7191-7192 . denotes .
T2525 7192-7354 sentence denotes Furthermore, the majority of inner segments showed some morphological differentiation, having approximately as many mitochondria as the control (Figure 1 and 2).
T2526 7193-7204 RB denotes Furthermore
T2527 7237-7243 VBD denotes showed
T2528 7204-7206 , denotes ,
T2529 7206-7209 DT denotes the
T2530 7210-7218 NN denotes majority
T2531 7219-7221 IN denotes of
T2532 7222-7227 JJ denotes inner
T2533 7228-7236 NNS denotes segments
T2534 7244-7248 DT denotes some
T2535 7263-7278 NN denotes differentiation
T2536 7249-7262 JJ denotes morphological
T2537 7278-7280 , denotes ,
T2538 7280-7286 VBG denotes having
T2539 7287-7300 RB denotes approximately
T2540 7304-7308 JJ denotes many
T2541 7301-7303 RB denotes as
T2542 7309-7321 NNS denotes mitochondria
T2543 7322-7324 IN denotes as
T2544 7325-7328 DT denotes the
T2545 7329-7336 NN denotes control
T2546 7337-7338 -LRB- denotes (
T2547 7345-7346 CD denotes 1
T2641 8256-8258 IN denotes in
T2642 8259-8262 NN denotes Crx
T2643 8266-8273 NNS denotes retinas
T2644 8262-8263 SYM denotes -
T2645 8263-8264 HYPH denotes /
T2646 8264-8265 SYM denotes -
T2647 8273-8275 , denotes ,
T2648 8275-8283 JJ denotes numerous
T2649 8290-8298 NNS denotes sections
T2650 8284-8289 NN denotes cross
T2651 8299-8301 IN denotes of
T2652 8302-8312 JJ denotes connecting
T2653 8313-8318 NNS denotes cilia
T2654 8319-8323 VBD denotes were
T2655 8330-8331 -LRB- denotes (
T2656 8338-8340 CD denotes 3A
T2657 8331-8337 NN denotes Figure
T2658 8341-8344 CC denotes and
T2659 8345-8347 CD denotes 3B
T2660 8347-8348 -RRB- denotes )
T2661 8348-8349 . denotes .
T2662 8349-8449 sentence denotes Sporadically, connecting cilia contained other than the typical complement of microtubule doublets.
T2663 8350-8362 RB denotes Sporadically
T2664 8381-8390 VBD denotes contained
T2665 8362-8364 , denotes ,
T2666 8364-8374 JJ denotes connecting
T2667 8375-8380 NNS denotes cilia
T2668 8391-8396 JJ denotes other
T2669 8397-8401 IN denotes than
T2670 8402-8405 DT denotes the
T2671 8414-8424 NN denotes complement
T2672 8406-8413 JJ denotes typical
T2673 8425-8427 IN denotes of
T2674 8428-8439 NN denotes microtubule
T2675 8440-8448 NNS denotes doublets
T2676 8448-8449 . denotes .
T2677 8449-8545 sentence denotes For example, in Figure 3A, the connecting cilium labelled by arrowhead 1, shows 7 + 0 doublets.
T2678 8450-8453 IN denotes For
T2679 8524-8529 VBZ denotes shows
T2680 8454-8461 NN denotes example
T2681 8461-8463 , denotes ,
T2682 8463-8465 IN denotes in
T2683 8466-8472 NN denotes Figure
T2684 8473-8475 NN denotes 3A
T2685 8475-8477 , denotes ,
T2686 8477-8480 DT denotes the
T2687 8492-8498 NN denotes cilium
T2688 8481-8491 JJ denotes connecting
T2689 8499-8507 VBN denotes labelled
T2690 8508-8510 IN denotes by
T2691 8511-8520 NN denotes arrowhead
T2692 8521-8522 CD denotes 1
T2693 8522-8524 , denotes ,
T2694 8530-8531 CD denotes 7
T2695 8534-8535 CD denotes 0
T2696 8532-8533 SYM denotes +
T2697 8536-8544 NNS denotes doublets
T2698 8544-8545 . denotes .
T2699 8545-8650 sentence denotes The majority exhibited the characteristic 9 + 0 doublets (arrowhead 2 and 3 in Figure 3A and Figure 3B).
T2700 8546-8549 DT denotes The
T2701 8550-8558 NN denotes majority
T2702 8559-8568 VBD denotes exhibited
T2703 8569-8572 DT denotes the
T2704 8594-8602 NNS denotes doublets
T2705 8573-8587 JJ denotes characteristic
T2706 8588-8589 CD denotes 9
T2707 8592-8593 CD denotes 0
T2708 8590-8591 SYM denotes +
T2709 8603-8604 -LRB- denotes (
T2710 8614-8615 CD denotes 2
T2711 8604-8613 NN denotes arrowhead
T2712 8616-8619 CC denotes and
T2713 8620-8621 CD denotes 3
T2714 8622-8624 IN denotes in
T2715 8625-8631 NN denotes Figure
T2716 8632-8634 NN denotes 3A
T2717 8635-8638 CC denotes and
T2718 8639-8645 NN denotes Figure
T2719 8646-8648 NN denotes 3B
T2720 8648-8649 -RRB- denotes )
T2721 8649-8650 . denotes .
T2722 8650-8785 sentence denotes These observations indicate that in addition to inner segment formation, ciliogenesis is also largely intact in Crx-/- photoreceptors.
T2723 8651-8656 DT denotes These
T2724 8657-8669 NNS denotes observations
T2725 8670-8678 VBP denotes indicate
T2726 8679-8683 IN denotes that
T2727 8737-8739 VBZ denotes is
T2728 8684-8686 IN denotes in
T2729 8687-8695 NN denotes addition
T2730 8696-8698 IN denotes to
T2731 8699-8704 JJ denotes inner
T2732 8705-8712 NN denotes segment
T2733 8713-8722 NN denotes formation
T2734 8722-8724 , denotes ,
T2735 8724-8736 NN denotes ciliogenesis
T2736 8740-8744 RB denotes also
T2737 8745-8752 RB denotes largely
T2738 8753-8759 JJ denotes intact
T2739 8760-8762 IN denotes in
T2740 8763-8766 NN denotes Crx
T2741 8770-8784 NNS denotes photoreceptors
T2742 8766-8767 SYM denotes -
T2743 8767-8768 HYPH denotes /
T2744 8768-8769 SYM denotes -
T2745 8784-8785 . denotes .
T2746 8785-8929 sentence denotes Further, in Crx-/- retinas the retinal pigmented epithelium (PE) appeared normal, at least up to P21 (data not shown), the oldest age examined.
T2836 10239-10244 RB denotes First
T2837 10303-10308 VBN denotes noted
T2838 10244-10246 , denotes ,
T2839 10246-10248 DT denotes an
T2840 10258-10268 NN denotes deposition
T2841 10249-10257 JJ denotes abnormal
T2842 10269-10271 IN denotes of
T2843 10272-10278 NN denotes matrix
T2844 10279-10281 IN denotes of
T2845 10282-10289 JJ denotes unknown
T2846 10290-10298 NN denotes identity
T2847 10299-10302 VBD denotes was
T2848 10309-10310 -LRB- denotes (
T2849 10321-10323 NN denotes mx
T2850 10310-10316 NN denotes Figure
T2851 10317-10319 NN denotes 3A
T2852 10319-10321 , denotes ,
T2853 10323-10324 -RRB- denotes )
T2854 10324-10325 . denotes .
T2855 10325-10413 sentence denotes Second, sporadically displaced nuclei were found residing in the space abutting the PE.
T2856 10326-10332 RB denotes Second
T2857 10369-10374 VBN denotes found
T2858 10332-10334 , denotes ,
T2859 10334-10346 RB denotes sporadically
T2860 10347-10356 VBN denotes displaced
T2861 10357-10363 NNS denotes nuclei
T2862 10364-10368 VBD denotes were
T2863 10375-10383 VBG denotes residing
T2864 10384-10386 IN denotes in
T2865 10387-10390 DT denotes the
T2866 10391-10396 NN denotes space
T2867 10397-10405 VBG denotes abutting
T2868 10406-10409 DT denotes the
T2869 10410-10412 NN denotes PE
T2870 10412-10413 . denotes .
T2871 10413-10643 sentence denotes Occasionally, these nuclei appeared pyknotic (Figure 3A, n); but, more frequently exhibited the heterochromatin pattern typical of photoreceptors (data not shown), strongly suggesting that they belonged to ectopic photoreceptors.
T2872 10414-10426 RB denotes Occasionally
T2873 10441-10449 VBD denotes appeared
T2874 10426-10428 , denotes ,
T2875 10428-10433 DT denotes these
T2876 10434-10440 NNS denotes nuclei
T2877 10450-10458 JJ denotes pyknotic
T2878 10459-10460 -LRB- denotes (
T2879 10471-10472 NN denotes n
T2880 10460-10466 NN denotes Figure
T2881 10467-10469 NN denotes 3A
T2882 10469-10471 , denotes ,
T2883 10472-10473 -RRB- denotes )
T2884 10473-10474 : denotes ;
T2885 10475-10478 CC denotes but
T2886 10478-10480 , denotes ,
T2887 10480-10484 RBR denotes more
T2888 10485-10495 RB denotes frequently
T2889 10496-10505 VBD denotes exhibited
T2890 10506-10509 DT denotes the
T2891 10526-10533 NN denotes pattern
T2892 10510-10525 NN denotes heterochromatin
T2893 10534-10541 JJ denotes typical
T2894 10542-10544 IN denotes of
T2895 10545-10559 NNS denotes photoreceptors
T2896 10560-10561 -LRB- denotes (
T2897 10570-10575 VBN denotes shown
T2898 10561-10565 NNS denotes data
T2899 10566-10569 RB denotes not
T2900 10575-10576 -RRB- denotes )
T2901 10576-10578 , denotes ,
T2902 10578-10586 RB denotes strongly
T2903 10587-10597 VBG denotes suggesting
T2904 10598-10602 IN denotes that
T2905 10608-10616 VBD denotes belonged
T2906 10603-10607 PRP denotes they
T2907 10617-10619 IN denotes to
T2908 10620-10627 JJ denotes ectopic
T2909 10628-10642 NNS denotes photoreceptors
T2910 10642-10643 . denotes .
T2911 10643-10780 sentence denotes The third pathological entity noted in the outer segment layer were numerous small vesicles (Figure 3A arrow) 100 to 200 nm in diameter.
T2912 10644-10647 DT denotes The
T2913 10667-10673 NN denotes entity
T2914 10648-10653 JJ denotes third
T2915 10654-10666 JJ denotes pathological
T2916 10707-10711 VBD denotes were
T2917 10674-10679 VBN denotes noted
T2918 10680-10682 IN denotes in
T2919 10683-10686 DT denotes the
T2920 10701-10706 NN denotes layer
T2921 10687-10692 JJ denotes outer
T2922 10693-10700 NN denotes segment
T2923 10712-10720 JJ denotes numerous
T2924 10727-10735 NNS denotes vesicles
T2925 10721-10726 JJ denotes small
T2926 10736-10737 -LRB- denotes (
T2927 10747-10752 NN denotes arrow
T2928 10737-10743 NN denotes Figure
T2929 10744-10746 NN denotes 3A
T2930 10752-10753 -RRB- denotes )
T2931 10754-10757 CD denotes 100
T2932 10761-10764 CD denotes 200
T2933 10758-10760 IN denotes to
T2934 10765-10767 NN denotes nm
T2935 10768-10770 IN denotes in
T2936 10771-10779 NN denotes diameter
T2937 10779-10780 . denotes .
T2938 10780-10954 sentence denotes They appeared to be emerging from the inner segments, as scanning electron microscopic images showed spherical structures budding from the inner segments (Figure 3C, arrow).
T2939 10781-10785 PRP denotes They
T2940 10786-10794 VBD denotes appeared
T2941 10795-10797 TO denotes to
T2942 10801-10809 VBG denotes emerging
T2943 10798-10800 VB denotes be
T2944 10810-10814 IN denotes from
T2945 10815-10818 DT denotes the
T2946 10825-10833 NNS denotes segments
T2947 10819-10824 JJ denotes inner
T2948 10833-10835 , denotes ,
T2949 10835-10837 IN denotes as
T2950 10875-10881 VBD denotes showed
T2951 10838-10846 VBG denotes scanning
T2952 10847-10855 NN denotes electron
T2953 10856-10867 JJ denotes microscopic
T2954 10868-10874 NNS denotes images
T2955 10882-10891 JJ denotes spherical
T2956 10892-10902 NNS denotes structures
T2957 10903-10910 VBG denotes budding
T2958 10911-10915 IN denotes from
T2959 10916-10919 DT denotes the
T2960 10926-10934 NNS denotes segments
T2961 10920-10925 JJ denotes inner
T2962 10935-10936 -LRB- denotes (
T2963 10947-10952 NN denotes arrow
T2964 10936-10942 NN denotes Figure
T2965 10943-10945 NN denotes 3C
T2966 10945-10947 , denotes ,
T2967 10952-10953 -RRB- denotes )
T2968 10953-10954 . denotes .
T2969 10954-11140 sentence denotes In order to characterize further the morphogenesis of Crx-/- photoreceptors, the developing outer segment layer was viewed by scanning electron microscopy at P7, P14 and P21 (Figure 4).
T2970 10955-10957 IN denotes In
T2971 11071-11077 VBN denotes viewed
T2972 10958-10963 NN denotes order
T2973 10964-10966 TO denotes to
T2974 10967-10979 VB denotes characterize
T2975 10980-10987 RB denotes further
T2976 10988-10991 DT denotes the
T2977 10992-11005 NN denotes morphogenesis
T2978 11006-11008 IN denotes of
T2979 11009-11012 NN denotes Crx
T2980 11016-11030 NNS denotes photoreceptors
T2981 11012-11013 SYM denotes -
T2982 11013-11014 HYPH denotes /
T2983 11014-11015 SYM denotes -
T2984 11030-11032 , denotes ,
T2985 11032-11035 DT denotes the
T2986 11061-11066 NN denotes layer
T2987 11036-11046 VBG denotes developing
T2988 11047-11052 JJ denotes outer
T2989 11053-11060 NN denotes segment
T2990 11067-11070 VBD denotes was
T2991 11078-11080 IN denotes by
T2992 11081-11089 VBG denotes scanning
T2993 11099-11109 NN denotes microscopy
T2994 11090-11098 NN denotes electron
T2995 11110-11112 IN denotes at
T2996 11113-11115 NN denotes P7
T2997 11115-11117 , denotes ,
T2998 11117-11120 NN denotes P14
T2999 11121-11124 CC denotes and
T3000 11125-11128 NN denotes P21
T3001 11129-11130 -LRB- denotes (
T3002 11130-11136 NN denotes Figure
T3003 11137-11138 CD denotes 4
T3004 11138-11139 -RRB- denotes )
T3005 11139-11140 . denotes .
T3006 11140-11276 sentence denotes In Crx+/+ retinas, photoreceptor inner segments, connecting cilia, and the first rudimentary outer segment structures were noted at P7.
T3007 11141-11143 IN denotes In
T3008 11264-11269 VBN denotes noted
T3009 11144-11147 NN denotes Crx
T3010 11151-11158 NNS denotes retinas
T3011 11147-11148 SYM denotes +
T3012 11148-11149 HYPH denotes /
T3013 11149-11150 SYM denotes +
T3014 11158-11160 , denotes ,
T3015 11160-11173 NN denotes photoreceptor
T3016 11180-11188 NNS denotes segments
T3017 11174-11179 JJ denotes inner
T3018 11188-11190 , denotes ,
T3019 11190-11200 VBG denotes connecting
T3020 11201-11206 NNS denotes cilia
T3021 11206-11208 , denotes ,
T3022 11208-11211 CC denotes and
T3023 11212-11215 DT denotes the
T3024 11248-11258 NNS denotes structures
T3025 11216-11221 JJ denotes first
T3026 11222-11233 JJ denotes rudimentary
T3027 11234-11239 JJ denotes outer
T3028 11240-11247 NN denotes segment
T3029 11259-11263 VBD denotes were
T3030 11270-11272 IN denotes at
T3031 11273-11275 NN denotes P7
T3032 11275-11276 . denotes .
T3033 11276-11409 sentence denotes In the Crx-/- retina, only an occassional connecting cilium was noted emerging from inner segments at this stage (Figure 4A and 4B).
T3034 11277-11279 IN denotes In
T3035 11347-11355 VBG denotes emerging
T3036 11280-11283 DT denotes the
T3037 11291-11297 NN denotes retina
T3038 11284-11287 NN denotes Crx
T3039 11287-11288 SYM denotes -
T3040 11288-11289 HYPH denotes /
T3041 11289-11290 SYM denotes -
T3042 11297-11299 , denotes ,
T3043 11299-11303 RB denotes only
T3044 11330-11336 NN denotes cilium
T3045 11304-11306 DT denotes an
T3046 11307-11318 JJ denotes occassional
T3047 11319-11329 VBG denotes connecting
T3048 11337-11340 VBD denotes was
T3049 11341-11346 VBN denotes noted
T3050 11356-11360 IN denotes from
T3051 11361-11366 JJ denotes inner
T3052 11367-11375 NNS denotes segments
T3053 11376-11378 IN denotes at
T3054 11379-11383 DT denotes this
T3055 11384-11389 NN denotes stage
T3056 11390-11391 -LRB- denotes (
T3057 11398-11400 NN denotes 4A
T3058 11391-11397 NN denotes Figure
T3059 11401-11404 CC denotes and
T3060 11405-11407 NN denotes 4B
T3061 11407-11408 -RRB- denotes )
T3062 11408-11409 . denotes .
T3063 11409-11505 sentence denotes This observation was confirmed by comparison with transmission electron micrographs (Figure 5).
T3064 11410-11414 DT denotes This
T3065 11415-11426 NN denotes observation
T3066 11431-11440 VBN denotes confirmed
T3067 11427-11430 VBD denotes was
T3068 11441-11443 IN denotes by
T3069 11444-11454 NN denotes comparison
T3070 11455-11459 IN denotes with
T3071 11460-11472 NN denotes transmission
T3072 11482-11493 NNS denotes micrographs
T3073 11473-11481 NN denotes electron
T3074 11494-11495 -LRB- denotes (
T3075 11495-11501 NN denotes Figure
T3076 11502-11503 CD denotes 5
T3077 11503-11504 -RRB- denotes )
T3078 11504-11505 . denotes .
T3079 11505-11600 sentence denotes These differences are the earliest noted differences between Crx+/+ and Crx-/- photoreceptors.
T3080 11506-11511 DT denotes These
T3081 11512-11523 NNS denotes differences
T3082 11524-11527 VBP denotes are
T3083 11528-11531 DT denotes the
T3084 11547-11558 NNS denotes differences
T3085 11532-11540 JJS denotes earliest
T3086 11541-11546 VBN denotes noted
T3087 11559-11566 IN denotes between
T3088 11567-11570 NN denotes Crx
T3089 11585-11599 NNS denotes photoreceptors
T3090 11570-11571 SYM denotes +
T3091 11571-11572 HYPH denotes /
T3092 11572-11573 SYM denotes +
T3093 11574-11577 CC denotes and
T3094 11578-11581 NN denotes Crx
T3095 11581-11582 SYM denotes -
T3096 11582-11583 HYPH denotes /
T3097 11583-11584 SYM denotes -
T3098 11599-11600 . denotes .
T3099 11600-11753 sentence denotes At P14, elongating outer segments were noted on Crx+/+ photoreceptors, occasionally demonstrating a paddle-like structure at their apex (Figure 4C, os).
T3100 11601-11603 IN denotes At
T3101 11640-11645 VBN denotes noted
T3102 11604-11607 NN denotes P14
T3103 11607-11609 , denotes ,
T3104 11609-11619 VBG denotes elongating
T3105 11626-11634 NNS denotes segments
T3106 11620-11625 JJ denotes outer
T3107 11635-11639 VBD denotes were
T3108 11646-11648 IN denotes on
T3109 11649-11652 NN denotes Crx
T3110 11656-11670 NNS denotes photoreceptors
T3111 11652-11653 SYM denotes +
T3112 11653-11654 HYPH denotes /
T3113 11654-11655 SYM denotes +
T3114 11670-11672 , denotes ,
T3115 11672-11684 RB denotes occasionally
T3116 11685-11698 VBG denotes demonstrating
T3117 11699-11700 DT denotes a
T3118 11713-11722 NN denotes structure
T3119 11701-11707 NN denotes paddle
T3120 11708-11712 JJ denotes like
T3121 11707-11708 HYPH denotes -
T3122 11723-11725 IN denotes at
T3123 11726-11731 PRP$ denotes their
T3124 11732-11736 NN denotes apex
T3125 11737-11738 -LRB- denotes (
T3126 11749-11751 NN denotes os
T3127 11738-11744 NN denotes Figure
T3128 11745-11747 NN denotes 4C
T3129 11747-11749 , denotes ,
T3130 11751-11752 -RRB- denotes )
T3131 11752-11753 . denotes .
T3132 11753-11892 sentence denotes In Crx-/- retinae, the vast majority of photoreceptors at this stage demonstrated connecting cilia without outer segments (Figure 4D, cc).
T3133 11754-11756 IN denotes In
T3134 11823-11835 VBD denotes demonstrated
T3135 11757-11760 NN denotes Crx
T3136 11764-11771 NNS denotes retinae
T3137 11760-11761 SYM denotes -
T3138 11761-11762 HYPH denotes /
T3139 11762-11763 SYM denotes -
T3140 11771-11773 , denotes ,
T3141 11773-11776 DT denotes the
T3142 11782-11790 NN denotes majority
T3143 11777-11781 JJ denotes vast
T3144 11791-11793 IN denotes of
T3145 11794-11808 NNS denotes photoreceptors
T3146 11809-11811 IN denotes at
T3147 11812-11816 DT denotes this
T3148 11817-11822 NN denotes stage
T3149 11836-11846 VBG denotes connecting
T3150 11847-11852 NNS denotes cilia
T3151 11853-11860 IN denotes without
T3152 11861-11866 JJ denotes outer
T3153 11867-11875 NNS denotes segments
T3154 11876-11877 -LRB- denotes (
T3155 11888-11890 NN denotes cc
T3156 11877-11883 NN denotes Figure
T3157 11884-11886 NN denotes 4D
T3158 11886-11888 , denotes ,
T3159 11890-11891 -RRB- denotes )
T3160 11891-11892 . denotes .
T3161 11892-12065 sentence denotes Sporadically, Crx-/- photoreceptors would exhibit an irregular structure extending from a connecting cilium (Figure 4D, cc*) perhaps representing a malformed outer segment.
T3162 11893-11905 RB denotes Sporadically
T3163 11935-11942 VB denotes exhibit
T3164 11905-11907 , denotes ,
T3165 11907-11910 NN denotes Crx
T3166 11914-11928 NNS denotes photoreceptors
T3167 11910-11911 SYM denotes -
T3168 11911-11912 HYPH denotes /
T3169 11912-11913 SYM denotes -
T3170 11929-11934 MD denotes would
T3171 11943-11945 DT denotes an
T3172 11956-11965 NN denotes structure
T3173 11946-11955 JJ denotes irregular
T3174 11966-11975 VBG denotes extending
T3175 11976-11980 IN denotes from
T3176 11981-11982 DT denotes a
T3177 11994-12000 NN denotes cilium
T3178 11983-11993 VBG denotes connecting
T3179 12001-12002 -LRB- denotes (
T3180 12013-12016 NN denotes cc*
T3181 12002-12008 NN denotes Figure
T3182 12009-12011 NN denotes 4D
T3183 12011-12013 , denotes ,
T3184 12016-12017 -RRB- denotes )
T3185 12018-12025 RB denotes perhaps
T3186 12026-12038 VBG denotes representing
T3187 12039-12040 DT denotes a
T3188 12057-12064 NN denotes segment
T3189 12041-12050 JJ denotes malformed
T3190 12051-12056 JJ denotes outer
T3191 12064-12065 . denotes .
T3192 12065-12125 sentence denotes Such structures were also observed at P21 (Figure 4F, cc*).
T3193 12066-12070 JJ denotes Such
T3194 12071-12081 NNS denotes structures
T3195 12092-12100 VBN denotes observed
T3196 12082-12086 VBD denotes were
T3197 12087-12091 RB denotes also
T3198 12101-12103 IN denotes at
T3199 12104-12107 NN denotes P21
T3200 12108-12109 -LRB- denotes (
T3201 12120-12123 NN denotes cc*
T3202 12109-12115 NN denotes Figure
T3203 12116-12118 NN denotes 4F
T3204 12118-12120 , denotes ,
T3205 12123-12124 -RRB- denotes )
T3206 12124-12125 . denotes .
T3207 12125-12248 sentence denotes These putative, abnormal outer segments were only rarely noted in Crx+/+ at P14, and never at P21 (Figure 4C and 4E, cc*).
T3208 12126-12131 DT denotes These
T3209 12157-12165 NNS denotes segments
T3210 12132-12140 JJ denotes putative
T3211 12140-12142 , denotes ,
T3212 12142-12150 JJ denotes abnormal
T3213 12151-12156 JJ denotes outer
T3214 12183-12188 VBN denotes noted
T3215 12166-12170 VBD denotes were
T3216 12171-12175 RB denotes only
T3217 12176-12182 RB denotes rarely
T3218 12189-12191 IN denotes in
T3219 12192-12195 NN denotes Crx
T3220 12195-12196 SYM denotes +
T3221 12196-12197 HYPH denotes /
T3222 12197-12198 SYM denotes +
T3223 12199-12201 IN denotes at
T3224 12202-12205 NN denotes P14
T3225 12205-12207 , denotes ,
T3226 12207-12210 CC denotes and
T3227 12211-12216 RB denotes never
T3228 12217-12219 IN denotes at
T3229 12220-12223 NN denotes P21
T3230 12224-12225 -LRB- denotes (
T3231 12243-12245 NN denotes cc
T3232 12225-12231 NN denotes Figure
T3233 12232-12234 NN denotes 4C
T3234 12235-12238 CC denotes and
T3235 12239-12241 NN denotes 4E
T3236 12241-12243 , denotes ,
T3237 12245-12246 SYM denotes *
T3238 12246-12247 -RRB- denotes )
T3239 12247-12248 . denotes .
T3240 12248-12343 sentence denotes Further, in Crx-/- photoreceptors, unusually long connecting cilia were noted (Figure 4F, cc).
T3241 12249-12256 RB denotes Further
T3242 12321-12326 VBN denotes noted
T3243 12256-12258 , denotes ,
T3244 12258-12260 IN denotes in
T3245 12261-12264 NN denotes Crx
T3246 12268-12282 NNS denotes photoreceptors
T3247 12264-12265 SYM denotes -
T3248 12265-12266 HYPH denotes /
T3249 12266-12267 SYM denotes -
T3250 12282-12284 , denotes ,
T3251 12284-12293 RB denotes unusually
T3252 12294-12298 JJ denotes long
T3253 12310-12315 NNS denotes cilia
T3254 12299-12309 VBG denotes connecting
T3255 12316-12320 VBD denotes were
T3256 12327-12328 -LRB- denotes (
T3257 12339-12341 NN denotes cc
T3276 12395-12398 NN denotes P10
T3277 12398-12400 , denotes ,
T3278 12400-12403 NN denotes P14
T3279 12403-12405 , denotes ,
T3280 12405-12408 CC denotes and
T3281 12409-12412 NN denotes P21
T3282 12413-12415 IN denotes by
T3283 12416-12419 NN denotes TEM
T3284 12419-12421 , denotes ,
T3285 12434-12435 DT denotes a
T3286 12448-12452 NN denotes lack
T3287 12436-12447 JJ denotes distinctive
T3288 12453-12455 IN denotes of
T3289 12456-12459 DT denotes any
T3290 12460-12469 NN denotes structure
T3291 12470-12483 JJ denotes interpretable
T3292 12484-12486 IN denotes as
T3293 12487-12494 JJ denotes orderly
T3294 12495-12501 NNS denotes stacks
T3295 12502-12504 IN denotes of
T3296 12505-12510 NNS denotes discs
T3297 12511-12513 CC denotes or
T3298 12514-12521 VBG denotes forming
T3299 12522-12527 NNS denotes discs
T3300 12527-12528 . denotes .
T3301 12528-12742 sentence denotes These data demonstrate a complete absence of normal outer segment formation in the Crx mutant mouse, and the arrest of development of the photoreceptor appendage at the elongation stage of outer segment formation.
T3302 12529-12534 DT denotes These
T3303 12535-12539 NNS denotes data
T3304 12540-12551 VBP denotes demonstrate
T3305 12552-12553 DT denotes a
T3306 12563-12570 NN denotes absence
T3307 12554-12562 JJ denotes complete
T3308 12571-12573 IN denotes of
T3309 12574-12580 JJ denotes normal
T3310 12595-12604 NN denotes formation
T3311 12581-12586 JJ denotes outer
T3312 12587-12594 NN denotes segment
T3313 12605-12607 IN denotes in
T3314 12608-12611 DT denotes the
T3315 12623-12628 NN denotes mouse
T3316 12612-12615 NN denotes Crx
T3317 12616-12622 NN denotes mutant
T3318 12628-12630 , denotes ,
T3319 12630-12633 CC denotes and
T3320 12634-12637 DT denotes the
T3321 12638-12644 NN denotes arrest
T3322 12645-12647 IN denotes of
T3323 12648-12659 NN denotes development
T3324 12660-12662 IN denotes of
T3325 12663-12666 DT denotes the
T3326 12681-12690 NN denotes appendage
T3327 12667-12680 NN denotes photoreceptor
T3328 12691-12693 IN denotes at
T3329 12694-12697 DT denotes the
T3330 12709-12714 NN denotes stage
T3331 12698-12708 NN denotes elongation
T3332 12715-12717 IN denotes of
T3333 12718-12723 JJ denotes outer
T3334 12724-12731 NN denotes segment
T3335 12732-12741 NN denotes formation
T3336 12741-12742 . denotes .
T3337 12742-12745 sentence denotes Fi
T3338 12743-12745 NN denotes Fi
T3339 14048-14049 sentence denotes n
T3340 14048-14049 NN denotes n
T3341 14049-14052 sentence denotes all
T3342 14049-14050 VBG denotes a
T3343 14050-14051 NN denotes l
T3344 14051-14052 VBG denotes l
T3388 14172-14181 NN denotes Rhodopsin
T3389 14197-14200 VBP denotes are
T3390 14182-14185 CC denotes and
T3391 14186-14196 NN denotes peripherin
T3392 14201-14204 CD denotes two
T3393 14228-14233 NNS denotes genes
T3394 14205-14218 NN denotes photoreceptor
T3395 14219-14227 JJ denotes specific
T3396 14218-14219 HYPH denotes -
T3397 14234-14239 WP$ denotes whose
T3398 14240-14250 NN denotes expression
T3399 14268-14281 VBN denotes downregulated
T3400 14251-14253 VBZ denotes is
T3401 14254-14267 RB denotes significantly
T3402 14282-14284 IN denotes in
T3403 14285-14288 DT denotes the
T3404 14296-14303 NNS denotes retinae
T3405 14289-14292 NN denotes Crx
T3406 14292-14293 SYM denotes -
T3407 14293-14294 HYPH denotes /
T3408 14294-14295 SYM denotes -
T3409 14304-14305 -LRB- denotes [
T3410 14311-14313 CD denotes 35
T3411 14305-14307 CD denotes 10
T3412 14307-14308 , denotes ,
T3413 14308-14310 CD denotes 34
T3414 14310-14311 , denotes ,
T3415 14313-14314 -RRB- denotes ]
T3416 14314-14315 . denotes .
T3417 14315-14455 sentence denotes Loss of function mutations in each of these genes separately have been reported to result in a failure to elaborate outer segments [29,30].
T3418 14316-14320 NN denotes Loss
T3419 14333-14342 NNS denotes mutations
T3420 14321-14323 IN denotes of
T3421 14324-14332 NN denotes function
T3422 14387-14395 VBN denotes reported
T3423 14343-14345 IN denotes in
T3424 14346-14350 DT denotes each
T3425 14351-14353 IN denotes of
T3426 14354-14359 DT denotes these
T3427 14360-14365 NNS denotes genes
T3428 14366-14376 RB denotes separately
T3429 14377-14381 VBP denotes have
T3430 14382-14386 VBN denotes been
T3431 14396-14398 TO denotes to
T3432 14399-14405 VB denotes result
T3433 14406-14408 IN denotes in
T3434 14409-14410 DT denotes a
T3435 14411-14418 NN denotes failure
T3436 14419-14421 TO denotes to
T3437 14422-14431 VB denotes elaborate
T3438 14432-14437 JJ denotes outer
T3439 14438-14446 NNS denotes segments
T3440 14447-14448 -LRB- denotes [
T3441 14451-14453 CD denotes 30
T3442 14448-14450 CD denotes 29
T3443 14450-14451 , denotes ,
T3444 14453-14454 -RRB- denotes ]
T3445 14454-14455 . denotes .
T3446 14455-14625 sentence denotes Photoreceptors from these two mutant mice examined by SEM from the scleral side appeared highly similar to Crx-/- photoreceptors (compare Figure 4F to Figure 6A and 6B).
T3447 14456-14470 NNS denotes Photoreceptors
T3448 14536-14544 VBD denotes appeared
T3449 14471-14475 IN denotes from
T3450 14476-14481 DT denotes these
T3451 14493-14497 NNS denotes mice
T3452 14482-14485 CD denotes two
T3453 14486-14492 JJ denotes mutant
T3454 14498-14506 VBN denotes examined
T3455 14507-14509 IN denotes by
T3456 14510-14513 NN denotes SEM
T3457 14514-14518 IN denotes from
T3458 14519-14522 DT denotes the
T3459 14531-14535 NN denotes side
T3460 14523-14530 JJ denotes scleral
T3461 14545-14551 RB denotes highly
T3462 14552-14559 JJ denotes similar
T3463 14560-14562 IN denotes to
T3464 14563-14566 NN denotes Crx
T3465 14570-14584 NNS denotes photoreceptors
T3466 14566-14567 SYM denotes -
T3467 14567-14568 HYPH denotes /
T3468 14568-14569 SYM denotes -
T3469 14585-14586 -LRB- denotes (
T3470 14586-14593 VB denotes compare
T3471 14594-14600 NN denotes Figure
T3472 14601-14603 NN denotes 4F
T3473 14604-14606 IN denotes to
T3474 14607-14613 NN denotes Figure
T3475 14614-14616 NN denotes 6A
T3476 14617-14620 CC denotes and
T3477 14621-14623 NN denotes 6B
T3478 14623-14624 -RRB- denotes )
T3479 14624-14625 . denotes .
T3638 14860-14863 NN denotes Crx
T3639 14864-14866 VBZ denotes is
T3640 14867-14876 JJ denotes necessary
T3641 14877-14880 IN denotes for
T3642 14881-14884 DT denotes the
T3643 14885-14894 NN denotes formation
T3644 14895-14897 IN denotes of
T3645 14898-14911 NN denotes photoreceptor
T3646 14912-14921 NNS denotes terminals
T3647 14921-15136 sentence denotes In a previous study, we demonstrated that forced expression of a dominant-negative allele of Crx in developing rods blocked formation of both rod spherules in the outer plexiform layer (OPL) and outer segments [7].
T3648 14922-14924 IN denotes In
T3649 14946-14958 VBD denotes demonstrated
T3650 14925-14926 DT denotes a
T3651 14936-14941 NN denotes study
T3652 14927-14935 JJ denotes previous
T3653 14941-14943 , denotes ,
T3654 14943-14945 PRP denotes we
T3655 14959-14963 IN denotes that
T3656 15038-15045 VBD denotes blocked
T3657 14964-14970 VBN denotes forced
T3658 14971-14981 NN denotes expression
T3659 14982-14984 IN denotes of
T3660 14985-14986 DT denotes a
T3661 15005-15011 NN denotes allele
T3662 14987-14995 JJ denotes dominant
T3663 14996-15004 JJ denotes negative
T3664 14995-14996 HYPH denotes -
T3665 15012-15014 IN denotes of
T3666 15015-15018 NN denotes Crx
T3667 15019-15021 IN denotes in
T3668 15022-15032 VBG denotes developing
T3669 15033-15037 NNS denotes rods
T3670 15046-15055 NN denotes formation
T3671 15056-15058 IN denotes of
T3672 15059-15063 DT denotes both
T3673 15068-15077 NNS denotes spherules
T3674 15064-15067 NN denotes rod
T3675 15078-15080 IN denotes in
T3676 15081-15084 DT denotes the
T3677 15101-15106 NN denotes layer
T3678 15085-15090 JJ denotes outer
T3679 15091-15100 NN denotes plexiform
T3680 15107-15108 -LRB- denotes (
T3681 15108-15111 NN denotes OPL
T3682 15111-15112 -RRB- denotes )
T3683 15113-15116 CC denotes and
T3684 15117-15122 JJ denotes outer
T3685 15123-15131 NNS denotes segments
T3686 15132-15133 -LRB- denotes [
T3687 15133-15134 CD denotes 7
T3688 15134-15135 -RRB- denotes ]
T3689 15135-15136 . denotes .
T3690 15136-15241 sentence denotes To expand on these studies, the ultrastructure of photoreceptor synapses was examined in Crx-/- retinas.
T3691 15137-15139 TO denotes To
T3692 15140-15146 VB denotes expand
T3693 15214-15222 VBN denotes examined
T3694 15147-15149 IN denotes on
T3695 15150-15155 DT denotes these
T3696 15156-15163 NNS denotes studies
T3697 15163-15165 , denotes ,
T3698 15165-15168 DT denotes the
T3699 15169-15183 NN denotes ultrastructure
T3700 15184-15186 IN denotes of
T3701 15187-15200 NN denotes photoreceptor
T3702 15201-15209 NNS denotes synapses
T3703 15210-15213 VBD denotes was
T3704 15223-15225 IN denotes in
T3705 15226-15229 NN denotes Crx
T3706 15233-15240 NNS denotes retinas
T3707 15229-15230 SYM denotes -
T3708 15230-15231 HYPH denotes /
T3709 15231-15232 SYM denotes -
T3710 15240-15241 . denotes .
T3711 15241-15321 sentence denotes In Crx+/+ retinas at P21, newly mature rod spherules were abundant (Figure 7A).
T3712 15242-15244 IN denotes In
T3713 15295-15299 VBD denotes were
T3714 15245-15248 NN denotes Crx
T3715 15252-15259 NNS denotes retinas
T3716 15248-15249 SYM denotes +
T3717 15249-15250 HYPH denotes /
T3718 15250-15251 SYM denotes +
T3719 15260-15262 IN denotes at
T3720 15263-15266 NN denotes P21
T3721 15266-15268 , denotes ,
T3722 15268-15273 RB denotes newly
T3723 15274-15280 JJ denotes mature
T3724 15285-15294 NNS denotes spherules
T3725 15281-15284 NN denotes rod
T3726 15300-15308 JJ denotes abundant
T3727 15309-15310 -LRB- denotes (
T3728 15317-15319 NN denotes 7A
T3729 15310-15316 NN denotes Figure
T3730 15319-15320 -RRB- denotes )
T3731 15320-15321 . denotes .
T3732 15321-15498 sentence denotes The sperules were blunt or club-shaped structures with a single ribbon associated with a single invaginating synapse (Figure 7A, arrow indicates one example; Figure 8A and 8B).
T3733 15322-15325 DT denotes The
T3734 15326-15334 NNS denotes sperules
T3735 15335-15339 VBD denotes were
T3736 15340-15345 JJ denotes blunt
T3737 15361-15371 NNS denotes structures
T3738 15346-15348 CC denotes or
T3739 15349-15353 NN denotes club
T3740 15354-15360 VBN denotes shaped
T3741 15353-15354 HYPH denotes -
T3742 15372-15376 IN denotes with
T3743 15377-15378 DT denotes a
T3744 15386-15392 NN denotes ribbon
T3745 15379-15385 JJ denotes single
T3746 15393-15403 VBN denotes associated
T3747 15404-15408 IN denotes with
T3748 15409-15410 DT denotes a
T3749 15431-15438 NN denotes synapse
T3750 15411-15417 JJ denotes single
T3751 15418-15430 VBG denotes invaginating
T3752 15439-15440 -LRB- denotes (
T3753 15487-15489 NN denotes 8A
T3754 15440-15446 NN denotes Figure
T3755 15447-15449 NN denotes 7A
T3756 15449-15451 , denotes ,
T3757 15451-15456 NN denotes arrow
T3758 15457-15466 VBZ denotes indicates
T3759 15467-15470 CD denotes one
T3760 15471-15478 NN denotes example
T3761 15478-15479 : denotes ;
T3762 15480-15486 NN denotes Figure
T3763 15490-15493 CC denotes and
T3764 15494-15496 NN denotes 8B
T3765 15496-15497 -RRB- denotes )
T3766 15497-15498 . denotes .
T3767 15498-15717 sentence denotes Two processes from horizontal cells were situated on either side of the synaptic ridge (Figure 8B, labelled H) and one or more dendrites of rod bipolar cells occupied a central position (Figure 8B, bipolar labelled B).
T3768 15499-15502 CD denotes Two
T3769 15503-15512 NNS denotes processes
T3770 15540-15548 VBN denotes situated
T3771 15513-15517 IN denotes from
T3772 15518-15528 JJ denotes horizontal
T3773 15529-15534 NNS denotes cells
T3774 15535-15539 VBD denotes were
T3775 15549-15551 IN denotes on
T3776 15552-15558 DT denotes either
T3777 15559-15563 NN denotes side
T3778 15564-15566 IN denotes of
T3779 15567-15570 DT denotes the
T3780 15580-15585 NN denotes ridge
T3781 15571-15579 JJ denotes synaptic
T3782 15586-15587 -LRB- denotes (
T3783 15594-15596 NN denotes 8B
T3784 15587-15593 NN denotes Figure
T3785 15596-15598 , denotes ,
T3786 15598-15606 VBN denotes labelled
T3787 15607-15608 NN denotes H
T3788 15608-15609 -RRB- denotes )
T3789 15610-15613 CC denotes and
T3790 15614-15617 CD denotes one
T3791 15626-15635 NNS denotes dendrites
T3792 15618-15620 CC denotes or
T3793 15621-15625 JJR denotes more
T3794 15657-15665 VBD denotes occupied
T3795 15636-15638 IN denotes of
T3796 15639-15642 NN denotes rod
T3797 15651-15656 NNS denotes cells
T3798 15643-15650 JJ denotes bipolar
T3799 15666-15667 DT denotes a
T3800 15676-15684 NN denotes position
T3801 15668-15675 JJ denotes central
T3802 15685-15686 -LRB- denotes (
T3803 15714-15715 NN denotes B
T3804 15686-15692 NN denotes Figure
T3805 15693-15695 NN denotes 8B
T3806 15695-15697 , denotes ,
T3807 15697-15704 JJ denotes bipolar
T3808 15705-15713 VBN denotes labelled
T3809 15715-15716 -RRB- denotes )
T3810 15716-15717 . denotes .
T3811 15717-15864 sentence denotes Cone terminals are large, flat pedicles that exhibit many invaginating synapses containing separate sets of horizontal and bipolar cell processes.
T3812 15718-15722 NN denotes Cone
T3813 15723-15732 NNS denotes terminals
T3814 15733-15736 VBP denotes are
T3815 15737-15742 JJ denotes large
T3816 15744-15748 JJ denotes flat
T3817 15742-15744 , denotes ,
T3818 15749-15757 NNS denotes pedicles
T3819 15758-15762 WDT denotes that
T3820 15763-15770 VBP denotes exhibit
T3821 15771-15775 JJ denotes many
T3822 15789-15797 NNS denotes synapses
T3823 15776-15788 VBG denotes invaginating
T3824 15798-15808 VBG denotes containing
T3825 15809-15817 JJ denotes separate
T3826 15818-15822 NNS denotes sets
T3827 15823-15825 IN denotes of
T3828 15826-15836 JJ denotes horizontal
T3829 15854-15863 NNS denotes processes
T3830 15837-15840 CC denotes and
T3831 15841-15848 JJ denotes bipolar
T3832 15849-15853 NN denotes cell
T3833 15863-15864 . denotes .
T3834 15864-15904 sentence denotes Each pedicle contains numerous ribbons.
T3835 15865-15869 DT denotes Each
T3836 15870-15877 NN denotes pedicle
T3837 15878-15886 VBZ denotes contains
T3838 15887-15895 JJ denotes numerous
T3839 15896-15903 NNS denotes ribbons
T3840 15903-15904 . denotes .
T3841 15904-15999 sentence denotes These terminals were much less common than spherules in Crx+/+ retinas at P21 (Figure 7, box).
T3842 15905-15910 DT denotes These
T3843 15911-15920 NNS denotes terminals
T3844 15921-15925 VBD denotes were
T3845 15926-15930 RB denotes much
T3846 15931-15935 RBR denotes less
T3847 15936-15942 JJ denotes common
T3848 15943-15947 IN denotes than
T3849 15948-15957 NNS denotes spherules
T3850 15958-15960 IN denotes in
T3851 15961-15964 NN denotes Crx
T3852 15968-15975 NNS denotes retinas
T3853 15964-15965 SYM denotes +
T3854 15965-15966 HYPH denotes /
T3855 15966-15967 SYM denotes +
T3856 15976-15978 IN denotes at
T3857 15979-15982 NN denotes P21
T3858 15983-15984 -LRB- denotes (
T3859 15994-15997 NN denotes box
T3860 15984-15990 NN denotes Figure
T3861 15991-15992 CD denotes 7
T3862 15992-15994 , denotes ,
T3863 15997-15998 -RRB- denotes )
T3864 15998-15999 . denotes .
T3865 15999-16106 sentence denotes In the OPL of Crx-/- retinas, photoreceptor terminals were highly disorganized at P21 (Figure 7B, arrows).
T3866 16000-16002 IN denotes In
T3867 16054-16058 VBD denotes were
T3868 16003-16006 DT denotes the
T3869 16007-16010 NN denotes OPL
T3870 16011-16013 IN denotes of
T3871 16014-16017 NN denotes Crx
T3872 16021-16028 NNS denotes retinas
T3873 16017-16018 SYM denotes -
T3874 16018-16019 HYPH denotes /
T3875 16019-16020 SYM denotes -
T3876 16028-16030 , denotes ,
T3877 16030-16043 NN denotes photoreceptor
T3878 16044-16053 NNS denotes terminals
T3879 16059-16065 RB denotes highly
T3880 16066-16078 JJ denotes disorganized
T3881 16079-16081 IN denotes at
T3882 16082-16085 NN denotes P21
T3883 16086-16087 -LRB- denotes (
T3884 16098-16104 NNS denotes arrows
T3885 16087-16093 NN denotes Figure
T3886 16094-16096 NN denotes 7B
T3887 16096-16098 , denotes ,
T3888 16104-16105 -RRB- denotes )
T3889 16105-16106 . denotes .
T3890 16106-16249 sentence denotes Processes containing synaptic vesicles and ribbon-like structures were apparent, suggesting at least limited generation of synapse components.
T3891 16107-16116 NNS denotes Processes
T3892 16173-16177 VBD denotes were
T3893 16117-16127 VBG denotes containing
T3894 16128-16136 JJ denotes synaptic
T3895 16137-16145 NNS denotes vesicles
T3896 16146-16149 CC denotes and
T3897 16150-16156 NN denotes ribbon
T3898 16157-16161 JJ denotes like
T3899 16156-16157 HYPH denotes -
T3900 16162-16172 NNS denotes structures
T3901 16178-16186 JJ denotes apparent
T3902 16186-16188 , denotes ,
T3903 16188-16198 VBG denotes suggesting
T3904 16199-16201 RB denotes at
T3905 16202-16207 RBS denotes least
T3906 16208-16215 JJ denotes limited
T3907 16216-16226 NN denotes generation
T3908 16227-16229 IN denotes of
T3909 16230-16237 NN denotes synapse
T3910 16238-16248 NNS denotes components
T3911 16248-16249 . denotes .
T3912 16249-16312 sentence denotes However, well formed spherules and pedicles were not observed.
T3913 16250-16257 RB denotes However
T3914 16303-16311 VBN denotes observed
T3915 16257-16259 , denotes ,
T3916 16259-16263 RB denotes well
T3917 16264-16270 VBN denotes formed
T3918 16271-16280 NNS denotes spherules
T3919 16281-16284 CC denotes and
T3920 16285-16293 NNS denotes pedicles
T3921 16294-16298 VBD denotes were
T3922 16299-16302 RB denotes not
T3923 16311-16312 . denotes .
T3924 16312-16490 sentence denotes In addition, many terminals appeared to contain multiple ribbons (Figure 8C and 8D, r) not tethered to the plasma membrane and occasionally in perinuclear positions (Figure 8D).
T3925 16313-16315 IN denotes In
T3926 16341-16349 VBD denotes appeared
T3927 16316-16324 NN denotes addition
T3928 16324-16326 , denotes ,
T3929 16326-16330 JJ denotes many
T3930 16331-16340 NNS denotes terminals
T3931 16350-16352 TO denotes to
T3932 16353-16360 VB denotes contain
T3933 16361-16369 JJ denotes multiple
T3934 16370-16377 NNS denotes ribbons
T3935 16378-16379 -LRB- denotes (
T3936 16397-16398 NN denotes r
T3937 16379-16385 NN denotes Figure
T3938 16386-16388 NN denotes 8C
T3939 16389-16392 CC denotes and
T3940 16393-16395 NN denotes 8D
T3941 16395-16397 , denotes ,
T3942 16398-16399 -RRB- denotes )
T3943 16400-16403 RB denotes not
T3944 16404-16412 VBN denotes tethered
T3945 16413-16415 IN denotes to
T3946 16416-16419 DT denotes the
T3947 16427-16435 NN denotes membrane
T3948 16420-16426 NN denotes plasma
T3949 16436-16439 CC denotes and
T3950 16440-16452 RB denotes occasionally
T3951 16453-16455 IN denotes in
T3952 16456-16467 JJ denotes perinuclear
T3953 16468-16477 NNS denotes positions
T3954 16478-16479 -LRB- denotes (
T3955 16486-16488 NN denotes 8D
T3956 16479-16485 NN denotes Figure
T3957 16488-16489 -RRB- denotes )
T3958 16489-16490 . denotes .
T4008 18857-18859 IN denotes In
T4009 18929-18936 VBN denotes carried
T4010 18860-18864 DT denotes this
T4011 18865-18870 NN denotes study
T4012 18870-18872 , denotes ,
T4013 18872-18874 DT denotes an
T4014 18891-18899 NN denotes analysis
T4015 18875-18890 JJ denotes ultrastructural
T4016 18900-18902 IN denotes of
T4017 18903-18906 NN denotes Crx
T4018 18910-18924 NNS denotes photoreceptors
T4019 18906-18907 SYM denotes -
T4020 18907-18908 HYPH denotes /
T4021 18908-18909 SYM denotes -
T4022 18925-18928 VBD denotes was
T4023 18937-18940 RP denotes out
T4024 18940-18941 . denotes .
T4025 18941-19101 sentence denotes As Crx mutations have been associated with Leber's congenital amaurosis, the findings in this study broaden our understanding of the pathology of this disease.
T4026 18942-18944 IN denotes As
T4027 18969-18979 VBN denotes associated
T4028 18945-18948 NN denotes Crx
T4029 18949-18958 NNS denotes mutations
T4030 18959-18963 VBP denotes have
T4031 18964-18968 VBN denotes been
T4032 19042-19049 VBD denotes broaden
T4033 18980-18984 IN denotes with
T4034 18985-18990 NNP denotes Leber
T4035 19004-19013 NN denotes amaurosis
T4036 18990-18992 POS denotes 's
T4037 18993-19003 JJ denotes congenital
T4038 19013-19015 , denotes ,
T4039 19015-19018 DT denotes the
T4040 19019-19027 NNS denotes findings
T4041 19028-19030 IN denotes in
T4042 19031-19035 DT denotes this
T4043 19036-19041 NN denotes study
T4044 19050-19053 PRP$ denotes our
T4045 19054-19067 NN denotes understanding
T4046 19068-19070 IN denotes of
T4047 19071-19074 DT denotes the
T4048 19075-19084 NN denotes pathology
T4049 19085-19087 IN denotes of
T4050 19088-19092 DT denotes this
T4051 19093-19100 NN denotes disease
T4052 19100-19101 . denotes .
T4053 19101-19388 sentence denotes Two prominent pathologies were characterized in the Crx-/- retina: (1) An absolute block in outer segment morphogenesis was noted, with the block occuring at the elongation stage of outer segment formation; (2) Crx-/- photoreceptors exhibited a severe perturbation in synapse formation.
T4054 19102-19105 CD denotes Two
T4055 19116-19127 NNS denotes pathologies
T4056 19106-19115 JJ denotes prominent
T4057 19133-19146 VBN denotes characterized
T4058 19128-19132 VBD denotes were
T4059 19335-19344 VBD denotes exhibited
T4060 19147-19149 IN denotes in
T4061 19150-19153 DT denotes the
T4062 19161-19167 NN denotes retina
T4063 19154-19157 NN denotes Crx
T4064 19157-19158 SYM denotes -
T4065 19158-19159 HYPH denotes /
T4066 19159-19160 SYM denotes -
T4067 19167-19169 : denotes :
T4068 19169-19170 -LRB- denotes (
T4069 19170-19171 LS denotes 1
T4070 19226-19231 VBN denotes noted
T4071 19171-19172 -RRB- denotes )
T4072 19173-19175 DT denotes An
T4073 19185-19190 NN denotes block
T4074 19176-19184 JJ denotes absolute
T4075 19191-19193 IN denotes in
T4076 19194-19199 JJ denotes outer
T4077 19200-19207 NN denotes segment
T4078 19208-19221 NN denotes morphogenesis
T4079 19222-19225 VBD denotes was
T4080 19231-19233 , denotes ,
T4081 19233-19237 IN denotes with
T4082 19238-19241 DT denotes the
T4083 19242-19247 NN denotes block
T4084 19248-19256 VBG denotes occuring
T4085 19257-19259 IN denotes at
T4086 19260-19263 DT denotes the
T4087 19275-19280 NN denotes stage
T4088 19264-19274 NN denotes elongation
T4089 19281-19283 IN denotes of
T4090 19284-19289 JJ denotes outer
T4091 19290-19297 NN denotes segment
T4092 19298-19307 NN denotes formation
T4093 19307-19308 : denotes ;
T4094 19309-19310 -LRB- denotes (
T4095 19310-19311 LS denotes 2
T4096 19311-19312 -RRB- denotes )
T4097 19313-19316 NN denotes Crx
T4098 19320-19334 NNS denotes photoreceptors
T4099 19316-19317 SYM denotes -
T4100 19317-19318 HYPH denotes /
T4101 19318-19319 SYM denotes -
T4102 19345-19346 DT denotes a
T4103 19354-19366 NN denotes perturbation
T4104 19347-19353 JJ denotes severe
T4105 19367-19369 IN denotes in
T4106 19370-19377 NN denotes synapse
T4107 19378-19387 NN denotes formation
T4108 19387-19388 . denotes .
T4109 19388-19475 sentence denotes This represents the first report of a synaptogenesis defect in an animal model of LCA.
T4110 19389-19393 DT denotes This
T4111 19394-19404 VBZ denotes represents
T4112 19405-19408 DT denotes the
T4113 19415-19421 NN denotes report
T4114 19409-19414 JJ denotes first
T4115 19422-19424 IN denotes of
T4116 19425-19426 DT denotes a
T4117 19442-19448 NN denotes defect
T4118 19427-19441 NN denotes synaptogenesis
T4119 19449-19451 IN denotes in
T4120 19452-19454 DT denotes an
T4121 19462-19467 NN denotes model
T4122 19455-19461 NN denotes animal
T4123 19468-19470 IN denotes of
T4124 19471-19474 NN denotes LCA
T4125 19474-19475 . denotes .
T4696 19477-19480 NN denotes Crx
T4697 19484-19498 NNS denotes photoreceptors
T4698 19480-19481 SYM denotes -
T4699 19481-19482 HYPH denotes /
T4700 19482-19483 SYM denotes -
T4701 19506-19514 VB denotes complete
T4702 19499-19502 MD denotes can
T4703 19502-19505 RB denotes not
T4704 19515-19520 JJ denotes outer
T4705 19521-19528 NN denotes segment
T4706 19529-19542 NN denotes morphogenesis
T4707 19542-19655 sentence denotes Mutations in Crx represent one of a collection of gene mutations that lead to an outer segment formation defect.
T4708 19543-19552 NNS denotes Mutations
T4709 19560-19569 VBP denotes represent
T4710 19553-19555 IN denotes in
T4711 19556-19559 NN denotes Crx
T4712 19570-19573 CD denotes one
T4713 19574-19576 IN denotes of
T4714 19577-19578 DT denotes a
T4715 19579-19589 NN denotes collection
T4716 19590-19592 IN denotes of
T4717 19593-19597 NN denotes gene
T4718 19598-19607 NNS denotes mutations
T4719 19608-19612 WDT denotes that
T4720 19613-19617 VBP denotes lead
T4721 19618-19620 IN denotes to
T4722 19621-19623 DT denotes an
T4723 19648-19654 NN denotes defect
T4724 19624-19629 JJ denotes outer
T4725 19630-19637 NN denotes segment
T4726 19638-19647 NN denotes formation
T4727 19654-19655 . denotes .
T4728 19655-19780 sentence denotes Homozygous null mutations in the peripherin/RDS gene [36] or in rhodopsin [29] lead to a failure of outer segment formation.
T4729 19656-19666 JJ denotes Homozygous
T4730 19672-19681 NNS denotes mutations
T4731 19667-19671 JJ denotes null
T4732 19735-19739 VBP denotes lead
T4733 19682-19684 IN denotes in
T4734 19685-19688 DT denotes the
T4735 19704-19708 NN denotes gene
T4736 19689-19699 NN denotes peripherin
T4737 19700-19703 NN denotes RDS
T4738 19699-19700 HYPH denotes /
T4739 19709-19710 -LRB- denotes [
T4740 19710-19712 CD denotes 36
T4741 19712-19713 -RRB- denotes ]
T4742 19714-19716 CC denotes or
T4743 19717-19719 IN denotes in
T4744 19720-19729 NN denotes rhodopsin
T4745 19730-19731 -LRB- denotes [
T4746 19731-19733 CD denotes 29
T4747 19733-19734 -RRB- denotes ]
T4748 19740-19742 IN denotes to
T4749 19743-19744 DT denotes a
T4750 19745-19752 NN denotes failure
T4751 19753-19755 IN denotes of
T4752 19756-19761 JJ denotes outer
T4753 19762-19769 NN denotes segment
T4754 19770-19779 NN denotes formation
T4755 19779-19780 . denotes .
T4756 19780-19880 sentence denotes The deficits in peripherin-/- and Crx-/- photoreceptor morphogenesis were found to be very similar.
T4757 19781-19784 DT denotes The
T4758 19785-19793 NNS denotes deficits
T4759 19855-19860 VBN denotes found
T4760 19794-19796 IN denotes in
T4761 19797-19807 NN denotes peripherin
T4762 19836-19849 NN denotes morphogenesis
T4763 19807-19808 SYM denotes -
T4764 19808-19809 HYPH denotes /
T4765 19809-19810 SYM denotes -
T4766 19811-19814 CC denotes and
T4767 19815-19818 NN denotes Crx
T4768 19818-19819 SYM denotes -
T4769 19819-19820 HYPH denotes /
T4770 19820-19821 SYM denotes -
T4771 19822-19835 NN denotes photoreceptor
T4772 19850-19854 VBD denotes were
T4773 19861-19863 TO denotes to
T4774 19864-19866 VB denotes be
T4775 19867-19871 RB denotes very
T4776 19872-19879 JJ denotes similar
T4777 19879-19880 . denotes .
T4778 19880-20016 sentence denotes Vesicular structures in Crx-/- photoreceptors were observed that were similar to those previously noted in the rds/peripherin-/- mouse.
T4779 19881-19890 JJ denotes Vesicular
T4780 19891-19901 NNS denotes structures
T4781 19932-19940 VBN denotes observed
T4782 19902-19904 IN denotes in
T4783 19905-19908 NN denotes Crx
T4784 19912-19926 NNS denotes photoreceptors
T4785 19908-19909 SYM denotes -
T4786 19909-19910 HYPH denotes /
T4787 19910-19911 SYM denotes -
T4788 19927-19931 VBD denotes were
T4789 19941-19945 WDT denotes that
T4790 19946-19950 VBD denotes were
T4791 19951-19958 JJ denotes similar
T4792 19959-19961 IN denotes to
T4793 19962-19967 DT denotes those
T4794 19968-19978 RB denotes previously
T4795 19979-19984 VBN denotes noted
T4796 19985-19987 IN denotes in
T4797 19988-19991 DT denotes the
T4798 20010-20015 NN denotes mouse
T4799 19992-19995 NN denotes rds
T4800 19996-20006 NN denotes peripherin
T4801 19995-19996 HYPH denotes /
T4802 20006-20007 SYM denotes -
T4803 20007-20008 HYPH denotes /
T4804 20008-20009 SYM denotes -
T4805 20015-20016 . denotes .
T4806 20016-20281 sentence denotes It was initially proposed that these vesicles were due to the breakdown of outer segment membranes that were not properly recruited to the outer segments in the absence of peripherin, or were from the result of the breakdown of the microvilli of Müller cells [30].
T4807 20017-20019 PRP denotes It
T4808 20034-20042 VBN denotes proposed
T4809 20020-20023 VBD denotes was
T4810 20024-20033 RB denotes initially
T4811 20043-20047 IN denotes that
T4812 20063-20067 VBD denotes were
T4813 20048-20053 DT denotes these
T4814 20054-20062 NNS denotes vesicles
T4815 20068-20071 IN denotes due
T4816 20072-20074 IN denotes to
T4817 20075-20078 DT denotes the
T4818 20079-20088 NN denotes breakdown
T4819 20089-20091 IN denotes of
T4820 20092-20097 JJ denotes outer
T4821 20098-20105 NN denotes segment
T4822 20106-20115 NNS denotes membranes
T4823 20116-20120 WDT denotes that
T4824 20139-20148 VBN denotes recruited
T4825 20121-20125 VBD denotes were
T4826 20126-20129 RB denotes not
T4827 20130-20138 RB denotes properly
T4828 20149-20151 IN denotes to
T4829 20152-20155 DT denotes the
T4830 20162-20170 NNS denotes segments
T4831 20156-20161 JJ denotes outer
T4832 20171-20173 IN denotes in
T4833 20174-20177 DT denotes the
T4834 20178-20185 NN denotes absence
T4835 20186-20188 IN denotes of
T4836 20189-20199 NN denotes peripherin
T4837 20199-20201 , denotes ,
T4838 20201-20203 CC denotes or
T4839 20204-20208 VBD denotes were
T4840 20209-20213 IN denotes from
T4841 20214-20217 DT denotes the
T4842 20218-20224 NN denotes result
T4843 20225-20227 IN denotes of
T4844 20228-20231 DT denotes the
T4845 20232-20241 NN denotes breakdown
T4846 20242-20244 IN denotes of
T4847 20245-20248 DT denotes the
T4848 20249-20259 NNS denotes microvilli
T4849 20260-20262 IN denotes of
T4850 20263-20269 NN denotes Müller
T4851 20270-20275 NNS denotes cells
T4852 20276-20277 -LRB- denotes [
T4853 20277-20279 CD denotes 30
T4854 20279-20280 -RRB- denotes ]
T4855 20280-20281 . denotes .
T4856 20281-20501 sentence denotes Strong support in favor of the former explanation was provided by Nir and colleagues who demonstrated the presence of rhodopsin protein in these vesicles using immunoelectron microscopy against a rhodopsin epitope [37].
T4857 20282-20288 JJ denotes Strong
T4858 20289-20296 NN denotes support
T4859 20336-20344 VBN denotes provided
T4860 20297-20299 IN denotes in
T4861 20300-20305 NN denotes favor
T4862 20306-20308 IN denotes of
T4863 20309-20312 DT denotes the
T4864 20320-20331 NN denotes explanation
T4865 20313-20319 JJ denotes former
T4866 20332-20335 VBD denotes was
T4867 20345-20347 IN denotes by
T4868 20348-20351 NN denotes Nir
T4869 20352-20355 CC denotes and
T4870 20356-20366 NNS denotes colleagues
T4871 20367-20370 WP denotes who
T4872 20371-20383 VBD denotes demonstrated
T4873 20384-20387 DT denotes the
T4874 20388-20396 NN denotes presence
T4875 20397-20399 IN denotes of
T4876 20400-20409 NN denotes rhodopsin
T4877 20410-20417 NN denotes protein
T4878 20418-20420 IN denotes in
T4879 20421-20426 DT denotes these
T4880 20427-20435 NNS denotes vesicles
T4881 20436-20441 VBG denotes using
T4882 20442-20456 NN denotes immunoelectron
T4883 20457-20467 NN denotes microscopy
T4884 20468-20475 IN denotes against
T4885 20476-20477 DT denotes a
T4886 20488-20495 NN denotes epitope
T4887 20478-20487 NN denotes rhodopsin
T4888 20496-20497 -LRB- denotes [
T4889 20497-20499 CD denotes 37
T4890 20499-20500 -RRB- denotes ]
T4891 20500-20501 . denotes .
T4892 20501-20588 sentence denotes Further, as shown here, the vesicles appear to bud from the inner segments themselves.
T4893 20502-20509 RB denotes Further
T4894 20539-20545 VBP denotes appear
T4895 20509-20511 , denotes ,
T4896 20511-20513 IN denotes as
T4897 20514-20519 VBN denotes shown
T4898 20520-20524 RB denotes here
T4899 20524-20526 , denotes ,
T4900 20526-20529 DT denotes the
T4901 20530-20538 NNS denotes vesicles
T4902 20546-20548 TO denotes to
T4903 20549-20552 VB denotes bud
T4904 20553-20557 IN denotes from
T4905 20558-20561 DT denotes the
T4906 20568-20576 NNS denotes segments
T4907 20562-20567 JJ denotes inner
T4908 20577-20587 PRP denotes themselves
T4909 20587-20588 . denotes .
T4910 20588-20766 sentence denotes In developing photoreceptors, an extraordinary growth process occurs whereby the outer segment is generated from the nascent connecting cilium (see [38] and references therein).
T4911 20589-20591 IN denotes In
T4912 20651-20657 VBZ denotes occurs
T4913 20592-20602 VBG denotes developing
T4914 20603-20617 NNS denotes photoreceptors
T4915 20617-20619 , denotes ,
T4916 20619-20621 DT denotes an
T4917 20643-20650 NN denotes process
T4918 20622-20635 JJ denotes extraordinary
T4919 20636-20642 NN denotes growth
T4920 20658-20665 WRB denotes whereby
T4921 20687-20696 VBN denotes generated
T4922 20666-20669 DT denotes the
T4923 20676-20683 NN denotes segment
T4924 20670-20675 JJ denotes outer
T4925 20684-20686 VBZ denotes is
T4926 20697-20701 IN denotes from
T4927 20702-20705 DT denotes the
T4928 20725-20731 NN denotes cilium
T4929 20706-20713 JJ denotes nascent
T4930 20714-20724 VBG denotes connecting
T4931 20732-20733 -LRB- denotes (
T4932 20733-20736 VB denotes see
T4933 20737-20738 -LRB- denotes [
T4934 20738-20740 CD denotes 38
T4935 20740-20741 -RRB- denotes ]
T4936 20742-20745 CC denotes and
T4937 20746-20756 NNS denotes references
T4938 20757-20764 RB denotes therein
T4939 20764-20765 -RRB- denotes )
T4940 20765-20766 . denotes .
T4941 20766-20970 sentence denotes Peripherin/RDS and ROM-1 proteins (localized in disc rims) and the opsin proteins (localized throughout the discs) have important roles in the structural integrity of mature outer segments (see [39,29]).
T4942 20767-20777 NN denotes Peripherin
T4943 20778-20781 NN denotes RDS
T4944 20777-20778 HYPH denotes /
T4945 20792-20800 NN denotes proteins
T4946 20782-20785 CC denotes and
T4947 20786-20789 NN denotes ROM
T4948 20789-20790 HYPH denotes -
T4949 20790-20791 CD denotes 1
T4950 20882-20886 VBP denotes have
T4951 20801-20802 -LRB- denotes (
T4952 20802-20811 VBN denotes localized
T4953 20812-20814 IN denotes in
T4954 20815-20819 NN denotes disc
T4955 20820-20824 NNS denotes rims
T4956 20824-20825 -RRB- denotes )
T4957 20826-20829 CC denotes and
T4958 20830-20833 DT denotes the
T4959 20840-20848 NN denotes proteins
T4960 20834-20839 NN denotes opsin
T4961 20849-20850 -LRB- denotes (
T4962 20850-20859 VBN denotes localized
T4963 20860-20870 IN denotes throughout
T4964 20871-20874 DT denotes the
T4965 20875-20880 NNS denotes discs
T4966 20880-20881 -RRB- denotes )
T4967 20887-20896 JJ denotes important
T4968 20897-20902 NNS denotes roles
T4969 20903-20905 IN denotes in
T4970 20906-20909 DT denotes the
T4971 20921-20930 NN denotes integrity
T4972 20910-20920 JJ denotes structural
T4973 20931-20933 IN denotes of
T4974 20934-20940 JJ denotes mature
T4975 20947-20955 NNS denotes segments
T4976 20941-20946 JJ denotes outer
T4977 20956-20957 -LRB- denotes (
T4978 20957-20960 VB denotes see
T4979 20961-20962 -LRB- denotes [
T4980 20962-20964 CD denotes 39
T4981 20965-20967 CD denotes 29
T4982 20964-20965 , denotes ,
T4983 20967-20968 -RRB- denotes ]
T4984 20968-20969 -RRB- denotes )
T4985 20969-20970 . denotes .
T4986 20970-21043 sentence denotes ROM-1-/- mice produce disorganized outer segments with large disks [40].
T4987 20971-20974 NN denotes ROM
T4988 20980-20984 NNS denotes mice
T4989 20974-20975 HYPH denotes -
T4990 20975-20976 CD denotes 1
T4991 20976-20977 SYM denotes -
T4992 20977-20978 HYPH denotes /
T4993 20978-20979 SYM denotes -
T4994 20985-20992 VBP denotes produce
T4995 20993-21005 VBN denotes disorganized
T4996 21012-21020 NNS denotes segments
T4997 21006-21011 JJ denotes outer
T4998 21021-21025 IN denotes with
T4999 21026-21031 JJ denotes large
T5000 21032-21037 NNS denotes disks
T5001 21038-21039 -LRB- denotes [
T5002 21039-21041 CD denotes 40
T5003 21041-21042 -RRB- denotes ]
T5004 21042-21043 . denotes .
T5005 21043-21247 sentence denotes Crx, by virtue of being a transcription factor, presumably controls genes that are responsible for the building and perhaps maintenance of the outer segment structure, including rhodopsin and peripherin.
T5006 21044-21047 NN denotes Crx
T5007 21103-21111 VBZ denotes controls
T5008 21047-21049 , denotes ,
T5009 21049-21051 IN denotes by
T5010 21052-21058 NN denotes virtue
T5011 21059-21061 IN denotes of
T5012 21062-21067 VBG denotes being
T5013 21068-21069 DT denotes a
T5014 21084-21090 NN denotes factor
T5015 21070-21083 NN denotes transcription
T5016 21090-21092 , denotes ,
T5017 21092-21102 RB denotes presumably
T5018 21112-21117 NNS denotes genes
T5019 21118-21122 WDT denotes that
T5020 21123-21126 VBP denotes are
T5021 21127-21138 JJ denotes responsible
T5022 21139-21142 IN denotes for
T5023 21143-21146 DT denotes the
T5024 21147-21155 NN denotes building
T5025 21156-21159 CC denotes and
T5026 21160-21167 RB denotes perhaps
T5027 21168-21179 NN denotes maintenance
T5028 21180-21182 IN denotes of
T5029 21183-21186 DT denotes the
T5030 21201-21210 NN denotes structure
T5031 21187-21192 JJ denotes outer
T5032 21193-21200 NN denotes segment
T5033 21210-21212 , denotes ,
T5034 21212-21221 VBG denotes including
T5035 21222-21231 NN denotes rhodopsin
T5036 21232-21235 CC denotes and
T5037 21236-21246 NN denotes peripherin
T5038 21246-21247 . denotes .
T5039 21247-21443 sentence denotes Using northern blots [34], microarrays [10], and serial analysis of gene expression (SAGE) [35], we have defined a large number of genes that are altered in their expression level in Crx-/- mice.
T5040 21248-21253 VBG denotes Using
T5041 21353-21360 VBN denotes defined
T5042 21254-21262 NNP denotes northern
T5043 21263-21268 NNS denotes blots
T5044 21269-21270 -LRB- denotes [
T5045 21270-21272 CD denotes 34
T5046 21272-21273 -RRB- denotes ]
T5047 21273-21275 , denotes ,
T5048 21275-21286 NNS denotes microarrays
T5049 21287-21288 -LRB- denotes [
T5050 21288-21290 CD denotes 10
T5051 21290-21291 -RRB- denotes ]
T5052 21291-21293 , denotes ,
T5053 21293-21296 CC denotes and
T5054 21297-21303 JJ denotes serial
T5055 21304-21312 NN denotes analysis
T5056 21313-21315 IN denotes of
T5057 21316-21320 NN denotes gene
T5058 21321-21331 NN denotes expression
T5059 21332-21333 -LRB- denotes (
T5060 21333-21337 NN denotes SAGE
T5061 21337-21338 -RRB- denotes )
T5062 21339-21340 -LRB- denotes [
T5063 21340-21342 CD denotes 35
T5064 21342-21343 -RRB- denotes ]
T5065 21343-21345 , denotes ,
T5066 21345-21347 PRP denotes we
T5067 21348-21352 VBP denotes have
T5068 21361-21362 DT denotes a
T5069 21369-21375 NN denotes number
T5070 21363-21368 JJ denotes large
T5071 21376-21378 IN denotes of
T5072 21379-21384 NNS denotes genes
T5073 21385-21389 WDT denotes that
T5074 21394-21401 VBN denotes altered
T5075 21390-21393 VBP denotes are
T5076 21402-21404 IN denotes in
T5077 21405-21410 PRP$ denotes their
T5078 21422-21427 NN denotes level
T5079 21411-21421 NN denotes expression
T5080 21428-21430 IN denotes in
T5081 21431-21434 NN denotes Crx
T5082 21438-21442 NNS denotes mice
T5083 21434-21435 SYM denotes -
T5084 21435-21436 HYPH denotes /
T5085 21436-21437 SYM denotes -
T5086 21442-21443 . denotes .
T5087 21443-21575 sentence denotes We found that rhodopsin expression was severely diminished in Crx-/- animals, and peripherin mRNA was reduced by approximately 30%.
T5088 21444-21446 PRP denotes We
T5089 21447-21452 VBD denotes found
T5090 21453-21457 IN denotes that
T5091 21492-21502 VBN denotes diminished
T5092 21458-21467 NN denotes rhodopsin
T5093 21468-21478 NN denotes expression
T5094 21479-21482 VBD denotes was
T5095 21483-21491 RB denotes severely
T5096 21503-21505 IN denotes in
T5097 21506-21509 NN denotes Crx
T5098 21513-21520 NNS denotes animals
T5099 21509-21510 SYM denotes -
T5100 21510-21511 HYPH denotes /
T5101 21511-21512 SYM denotes -
T5102 21520-21522 , denotes ,
T5103 21522-21525 CC denotes and
T5104 21526-21536 NN denotes peripherin
T5105 21537-21541 NN denotes mRNA
T5106 21546-21553 VBN denotes reduced
T5107 21542-21545 VBD denotes was
T5108 21554-21556 IN denotes by
T5109 21557-21570 RB denotes approximately
T5110 21571-21573 CD denotes 30
T5111 21573-21574 NN denotes %
T5112 21574-21575 . denotes .
T5113 21575-21744 sentence denotes Transgenic mice with variable levels of expression of wild type rhodopsin exhibit rod degeneration [41], indicating the importance of the level of rhodopsin expression.
T5114 21576-21586 JJ denotes Transgenic
T5115 21587-21591 NNS denotes mice
T5116 21650-21657 VBP denotes exhibit
T5117 21592-21596 IN denotes with
T5118 21597-21605 JJ denotes variable
T5119 21606-21612 NNS denotes levels
T5120 21613-21615 IN denotes of
T5121 21616-21626 NN denotes expression
T5122 21627-21629 IN denotes of
T5123 21630-21634 JJ denotes wild
T5124 21635-21639 NN denotes type
T5125 21640-21649 NN denotes rhodopsin
T5126 21658-21661 NN denotes rod
T5127 21662-21674 NN denotes degeneration
T5128 21675-21676 -LRB- denotes [
T5129 21676-21678 CD denotes 41
T5130 21678-21679 -RRB- denotes ]
T5131 21679-21681 , denotes ,
T5132 21681-21691 VBG denotes indicating
T5133 21692-21695 DT denotes the
T5134 21696-21706 NN denotes importance
T5135 21707-21709 IN denotes of
T5136 21710-21713 DT denotes the
T5137 21714-21719 NN denotes level
T5138 21720-21722 IN denotes of
T5139 21723-21732 NN denotes rhodopsin
T5140 21733-21743 NN denotes expression
T5141 21743-21744 . denotes .
T5142 21744-21854 sentence denotes In addition, the timing of rhodopsin expression may be very important, as indicated by studies in Drosophila.
T5143 21745-21747 IN denotes In
T5144 21797-21799 VB denotes be
T5145 21748-21756 NN denotes addition
T5146 21756-21758 , denotes ,
T5147 21758-21761 DT denotes the
T5148 21762-21768 NN denotes timing
T5149 21769-21771 IN denotes of
T5150 21772-21781 NN denotes rhodopsin
T5151 21782-21792 NN denotes expression
T5152 21793-21796 MD denotes may
T5153 21800-21804 RB denotes very
T5154 21805-21814 JJ denotes important
T5155 21814-21816 , denotes ,
T5156 21816-21818 IN denotes as
T5157 21819-21828 VBN denotes indicated
T5158 21829-21831 IN denotes by
T5159 21832-21839 NNS denotes studies
T5160 21840-21842 IN denotes in
T5161 21843-21853 NNP denotes Drosophila
T5162 21853-21854 . denotes .
T5163 21854-21925 sentence denotes In Drosophila, rhodopsin (ninaE) is expressed in photoreceptors R1–R6.
T5164 21855-21857 IN denotes In
T5165 21891-21900 VBN denotes expressed
T5166 21858-21868 NNP denotes Drosophila
T5167 21868-21870 , denotes ,
T5168 21870-21879 NN denotes rhodopsin
T5169 21880-21881 -LRB- denotes (
T5170 21881-21886 NN denotes ninaE
T5171 21886-21887 -RRB- denotes )
T5172 21888-21890 VBZ denotes is
T5173 21901-21903 IN denotes in
T5174 21904-21918 NNS denotes photoreceptors
T5175 21919-21921 NN denotes R1
T5176 21921-21922 SYM denotes –
T5177 21922-21924 NN denotes R6
T5178 21924-21925 . denotes .
T5179 21925-22119 sentence denotes In ninaE null mutants, the rhabdomere, a structure analogous to vertebrate outer segments, fails to develop in R1–R6 photoreceptors [42], reminiscent of the situation in rhodopsin-/- mice [29].
T5180 21926-21928 IN denotes In
T5181 22017-22022 VBZ denotes fails
T5182 21929-21934 NN denotes ninaE
T5183 21935-21939 JJ denotes null
T5184 21940-21947 NNS denotes mutants
T5185 21947-21949 , denotes ,
T5186 21949-21952 DT denotes the
T5187 21953-21963 NN denotes rhabdomere
T5188 21963-21965 , denotes ,
T5189 21965-21966 DT denotes a
T5190 21967-21976 NN denotes structure
T5191 21977-21986 JJ denotes analogous
T5192 21987-21989 IN denotes to
T5193 21990-22000 NN denotes vertebrate
T5194 22007-22015 NNS denotes segments
T5195 22001-22006 JJ denotes outer
T5196 22015-22017 , denotes ,
T5197 22023-22025 TO denotes to
T5198 22026-22033 VB denotes develop
T5199 22034-22036 IN denotes in
T5200 22037-22039 NN denotes R1
T5201 22043-22057 NNS denotes photoreceptors
T5202 22039-22040 SYM denotes –
T5203 22040-22042 NN denotes R6
T5204 22058-22059 -LRB- denotes [
T5205 22059-22061 CD denotes 42
T5206 22061-22062 -RRB- denotes ]
T5207 22062-22064 , denotes ,
T5208 22064-22075 JJ denotes reminiscent
T5209 22076-22078 IN denotes of
T5210 22079-22082 DT denotes the
T5211 22083-22092 NN denotes situation
T5212 22093-22095 IN denotes in
T5213 22096-22105 NN denotes rhodopsin
T5214 22109-22113 NNS denotes mice
T5215 22105-22106 SYM denotes -
T5216 22106-22107 HYPH denotes /
T5217 22107-22108 SYM denotes -
T5218 22114-22115 -LRB- denotes [
T5219 22115-22117 CD denotes 29
T5220 22117-22118 -RRB- denotes ]
T5221 22118-22119 . denotes .
T5222 22119-22257 sentence denotes An intriguing experiment by Kumar et al. [43] demonstrated a temporal requirement for rhodopsin expression during rhabdomere development.
T5223 22120-22122 DT denotes An
T5224 22134-22144 NN denotes experiment
T5225 22123-22133 JJ denotes intriguing
T5226 22166-22178 VBD denotes demonstrated
T5227 22145-22147 IN denotes by
T5228 22148-22153 NNP denotes Kumar
T5229 22154-22156 FW denotes et
T5230 22157-22160 FW denotes al.
T5231 22161-22162 -LRB- denotes [
T5232 22162-22164 CD denotes 43
T5233 22164-22165 -RRB- denotes ]
T5234 22179-22180 DT denotes a
T5235 22190-22201 NN denotes requirement
T5236 22181-22189 JJ denotes temporal
T5237 22202-22205 IN denotes for
T5238 22206-22215 NN denotes rhodopsin
T5239 22216-22226 NN denotes expression
T5240 22227-22233 IN denotes during
T5241 22234-22244 NN denotes rhabdomere
T5242 22245-22256 NN denotes development
T5243 22256-22257 . denotes .
T5244 22257-22403 sentence denotes In ninaE null flies, a ninaE transgene under the control of a heat shock promoter was subjected to various temperature shifts during development.
T5245 22258-22260 IN denotes In
T5246 22344-22353 VBN denotes subjected
T5247 22261-22266 NN denotes ninaE
T5248 22267-22271 JJ denotes null
T5249 22272-22277 NNS denotes flies
T5250 22277-22279 , denotes ,
T5251 22279-22280 DT denotes a
T5252 22287-22296 NN denotes transgene
T5253 22281-22286 NN denotes ninaE
T5254 22297-22302 IN denotes under
T5255 22303-22306 DT denotes the
T5256 22307-22314 NN denotes control
T5257 22315-22317 IN denotes of
T5258 22318-22319 DT denotes a
T5259 22331-22339 NN denotes promoter
T5260 22320-22324 NN denotes heat
T5261 22325-22330 NN denotes shock
T5262 22340-22343 VBD denotes was
T5263 22354-22356 IN denotes to
T5264 22357-22364 JJ denotes various
T5265 22377-22383 NNS denotes shifts
T5266 22365-22376 NN denotes temperature
T5267 22384-22390 IN denotes during
T5268 22391-22402 NN denotes development
T5269 22402-22403 . denotes .
T5270 22403-22581 sentence denotes Heat shock during the normal time of rhodopsin onset resulted in substantial and long-lasting rescue of photoreceptor structure and transient rescue of photoreceptor physiology.
T5271 22404-22408 NN denotes Heat
T5272 22409-22414 NN denotes shock
T5273 22457-22465 VBD denotes resulted
T5274 22415-22421 IN denotes during
T5275 22422-22425 DT denotes the
T5276 22433-22437 NN denotes time
T5277 22426-22432 JJ denotes normal
T5278 22438-22440 IN denotes of
T5279 22441-22450 NN denotes rhodopsin
T5280 22451-22456 NN denotes onset
T5281 22466-22468 IN denotes in
T5282 22469-22480 JJ denotes substantial
T5283 22498-22504 NN denotes rescue
T5284 22481-22484 CC denotes and
T5285 22485-22489 RB denotes long
T5286 22490-22497 VBG denotes lasting
T5287 22489-22490 HYPH denotes -
T5288 22505-22507 IN denotes of
T5289 22508-22521 NN denotes photoreceptor
T5290 22522-22531 NN denotes structure
T5291 22532-22535 CC denotes and
T5292 22536-22545 JJ denotes transient
T5293 22546-22552 NN denotes rescue
T5294 22553-22555 IN denotes of
T5295 22556-22569 NN denotes photoreceptor
T5296 22570-22580 NN denotes physiology
T5297 22580-22581 . denotes .
T5298 22581-22799 sentence denotes However, expression shortly before or after this critical period failed to rescue, suggesting that rhodopsin expression during a discrete window of time in development is essential for proper rhabdomere morphogenesis.
T5299 22582-22589 RB denotes However
T5300 22647-22653 VBD denotes failed
T5301 22589-22591 , denotes ,
T5302 22591-22601 NN denotes expression
T5303 22602-22609 RB denotes shortly
T5304 22610-22616 IN denotes before
T5305 22617-22619 CC denotes or
T5306 22620-22625 IN denotes after
T5307 22626-22630 DT denotes this
T5308 22640-22646 NN denotes period
T5309 22631-22639 JJ denotes critical
T5310 22654-22656 TO denotes to
T5311 22657-22663 VB denotes rescue
T5312 22663-22665 , denotes ,
T5313 22665-22675 VBG denotes suggesting
T5314 22676-22680 IN denotes that
T5315 22750-22752 VBZ denotes is
T5316 22681-22690 NN denotes rhodopsin
T5317 22691-22701 NN denotes expression
T5318 22702-22708 IN denotes during
T5319 22709-22710 DT denotes a
T5320 22720-22726 NN denotes window
T5321 22711-22719 JJ denotes discrete
T5322 22727-22729 IN denotes of
T5323 22730-22734 NN denotes time
T5324 22735-22737 IN denotes in
T5325 22738-22749 NN denotes development
T5326 22753-22762 JJ denotes essential
T5327 22763-22766 IN denotes for
T5328 22767-22773 JJ denotes proper
T5329 22785-22798 NN denotes morphogenesis
T5330 22774-22784 JJ denotes rhabdomere
T5331 22798-22799 . denotes .
T5332 22799-22960 sentence denotes This result is consistent with observations in the rat wherein rhodopsin onset occurs with strict timing in the developmental history of most rods in vivo [44].
T5333 22800-22804 DT denotes This
T5334 22805-22811 NN denotes result
T5335 22812-22814 VBZ denotes is
T5336 22815-22825 JJ denotes consistent
T5337 22826-22830 IN denotes with
T5338 22831-22843 NNS denotes observations
T5339 22844-22846 IN denotes in
T5340 22847-22850 DT denotes the
T5341 22851-22854 NN denotes rat
T5342 22855-22862 IN denotes wherein
T5343 22879-22885 VBZ denotes occurs
T5344 22863-22872 NN denotes rhodopsin
T5345 22873-22878 NN denotes onset
T5346 22886-22890 IN denotes with
T5347 22891-22897 JJ denotes strict
T5348 22898-22904 NN denotes timing
T5349 22905-22907 IN denotes in
T5350 22908-22911 DT denotes the
T5351 22926-22933 NN denotes history
T5352 22912-22925 JJ denotes developmental
T5353 22934-22936 IN denotes of
T5354 22937-22941 JJS denotes most
T5355 22942-22946 NNS denotes rods
T5356 22947-22949 FW denotes in
T5357 22950-22954 FW denotes vivo
T5358 22955-22956 -LRB- denotes [
T5359 22956-22958 CD denotes 44
T5360 22958-22959 -RRB- denotes ]
T5361 22959-22960 . denotes .
T5362 22960-23161 sentence denotes Thus, through its regulation of rhodopsin levels, or perhaps through control of the kinetics of the up-regulation of rhodopsin beginning at about P6, Crx may be regulating outer segment morphogenesis.
T5363 22961-22965 RB denotes Thus
T5364 23122-23132 VBG denotes regulating
T5365 22965-22967 , denotes ,
T5366 22967-22974 IN denotes through
T5367 22975-22978 PRP$ denotes its
T5368 22979-22989 NN denotes regulation
T5369 22990-22992 IN denotes of
T5370 22993-23002 NN denotes rhodopsin
T5371 23003-23009 NNS denotes levels
T5372 23009-23011 , denotes ,
T5373 23011-23013 CC denotes or
T5374 23014-23021 RB denotes perhaps
T5375 23022-23029 IN denotes through
T5376 23030-23037 NN denotes control
T5377 23038-23040 IN denotes of
T5378 23041-23044 DT denotes the
T5379 23045-23053 NN denotes kinetics
T5380 23054-23056 IN denotes of
T5381 23057-23060 DT denotes the
T5382 23064-23074 NN denotes regulation
T5383 23061-23063 JJ denotes up
T5384 23063-23064 HYPH denotes -
T5385 23075-23077 IN denotes of
T5386 23078-23087 NN denotes rhodopsin
T5387 23088-23097 VBG denotes beginning
T5388 23098-23100 IN denotes at
T5389 23101-23106 RB denotes about
T5390 23107-23109 NN denotes P6
T5391 23109-23111 , denotes ,
T5392 23111-23114 NN denotes Crx
T5393 23115-23118 MD denotes may
T5394 23119-23121 VB denotes be
T5395 23133-23138 JJ denotes outer
T5396 23139-23146 NN denotes segment
T5397 23147-23160 NN denotes morphogenesis
T5398 23160-23161 . denotes .
T5399 23161-23212 sentence denotes The similarty of the two cases may extend further.
T5400 23162-23165 DT denotes The
T5401 23166-23175 NN denotes similarty
T5402 23197-23203 VB denotes extend
T5403 23176-23178 IN denotes of
T5404 23179-23182 DT denotes the
T5405 23187-23192 NNS denotes cases
T5406 23183-23186 CD denotes two
T5407 23193-23196 MD denotes may
T5408 23204-23211 RB denotes further
T5409 23211-23212 . denotes .
T5410 23212-23344 sentence denotes At present, the closest Crx relative in Drosophila is Otd, the founding member of the class of homeobox genes to which Crx belongs.
T5411 23213-23215 IN denotes At
T5412 23264-23266 VBZ denotes is
T5413 23216-23223 JJ denotes present
T5414 23223-23225 , denotes ,
T5415 23225-23228 DT denotes the
T5416 23237-23240 NN denotes Crx
T5417 23229-23236 JJS denotes closest
T5418 23241-23249 JJ denotes relative
T5419 23250-23252 IN denotes in
T5420 23253-23263 NNP denotes Drosophila
T5421 23267-23270 NN denotes Otd
T5422 23270-23272 , denotes ,
T5423 23272-23275 DT denotes the
T5424 23285-23291 NN denotes member
T5425 23276-23284 JJ denotes founding
T5426 23292-23294 IN denotes of
T5427 23295-23298 DT denotes the
T5428 23299-23304 NN denotes class
T5429 23305-23307 IN denotes of
T5430 23308-23316 NN denotes homeobox
T5431 23317-23322 NNS denotes genes
T5432 23323-23325 IN denotes to
T5433 23336-23343 VBZ denotes belongs
T5434 23326-23331 WDT denotes which
T5435 23332-23335 NN denotes Crx
T5436 23343-23344 . denotes .
T5437 23344-23464 sentence denotes Interestingly, in one hypomorphic allele of Drosophila otd, otduvi, photoreceptor morphogenesis is also disrupted [45].
T5438 23345-23358 RB denotes Interestingly
T5439 23449-23458 VBN denotes disrupted
T5440 23358-23360 , denotes ,
T5441 23360-23362 IN denotes in
T5442 23363-23366 CD denotes one
T5443 23379-23385 NN denotes allele
T5444 23367-23378 JJ denotes hypomorphic
T5445 23386-23388 IN denotes of
T5446 23389-23399 NNP denotes Drosophila
T5447 23400-23403 NN denotes otd
T5448 23403-23405 , denotes ,
T5449 23405-23411 NN denotes otduvi
T5450 23411-23413 , denotes ,
T5451 23413-23426 NN denotes photoreceptor
T5452 23427-23440 NN denotes morphogenesis
T5453 23441-23443 VBZ denotes is
T5454 23444-23448 RB denotes also
T5455 23459-23460 -LRB- denotes [
T5456 23460-23462 CD denotes 45
T5457 23462-23463 -RRB- denotes ]
T5458 23463-23464 . denotes .
T5459 23464-23534 sentence denotes We found that there are many other genes that are dependent upon Crx.
T5460 23465-23467 PRP denotes We
T5461 23468-23473 VBD denotes found
T5462 23474-23478 IN denotes that
T5463 23485-23488 VBP denotes are
T5464 23479-23484 EX denotes there
T5465 23489-23493 JJ denotes many
T5466 23500-23505 NNS denotes genes
T5467 23494-23499 JJ denotes other
T5468 23506-23510 WDT denotes that
T5469 23511-23514 VBP denotes are
T5470 23515-23524 JJ denotes dependent
T5471 23525-23529 IN denotes upon
T5472 23530-23533 NN denotes Crx
T5473 23533-23534 . denotes .
T5474 23534-23727 sentence denotes Those that are expressed at a lower level in the Crx-/- retina, such as rhodopsin and peripherin, comprise many that are either enriched or specific to photoreceptors in their expression [35].
T5475 23535-23540 DT denotes Those
T5476 23633-23641 VBP denotes comprise
T5477 23541-23545 WDT denotes that
T5478 23550-23559 VBN denotes expressed
T5479 23546-23549 VBP denotes are
T5480 23560-23562 IN denotes at
T5481 23563-23564 DT denotes a
T5482 23571-23576 NN denotes level
T5483 23565-23570 JJR denotes lower
T5484 23577-23579 IN denotes in
T5485 23580-23583 DT denotes the
T5486 23591-23597 NN denotes retina
T5487 23584-23587 NN denotes Crx
T5488 23587-23588 SYM denotes -
T5489 23588-23589 HYPH denotes /
T5490 23589-23590 SYM denotes -
T5491 23597-23599 , denotes ,
T5492 23599-23603 JJ denotes such
T5493 23604-23606 IN denotes as
T5494 23607-23616 NN denotes rhodopsin
T5495 23617-23620 CC denotes and
T5496 23621-23631 NN denotes peripherin
T5497 23631-23633 , denotes ,
T5498 23642-23646 JJ denotes many
T5499 23647-23651 WDT denotes that
T5500 23652-23655 VBP denotes are
T5501 23656-23662 RB denotes either
T5502 23663-23671 VBN denotes enriched
T5503 23672-23674 CC denotes or
T5504 23675-23683 JJ denotes specific
T5505 23684-23686 IN denotes to
T5506 23687-23701 NNS denotes photoreceptors
T5507 23702-23704 IN denotes in
T5508 23705-23710 PRP$ denotes their
T5509 23711-23721 NN denotes expression
T5510 23722-23723 -LRB- denotes [
T5511 23723-23725 CD denotes 35
T5512 23725-23726 -RRB- denotes ]
T5513 23726-23727 . denotes .
T5514 23727-23943 sentence denotes They include enzymes that are important in lipid metabolism, protein folding and transport, as well as in other processes that one might envision would be important in building a structure such as the outer segment.
T5515 23728-23732 PRP denotes They
T5516 23733-23740 VBP denotes include
T5517 23741-23748 NNS denotes enzymes
T5518 23749-23753 WDT denotes that
T5519 23754-23757 VBP denotes are
T5520 23758-23767 JJ denotes important
T5521 23768-23770 IN denotes in
T5522 23771-23776 NN denotes lipid
T5523 23777-23787 NN denotes metabolism
T5524 23787-23789 , denotes ,
T5525 23789-23796 NN denotes protein
T5526 23797-23804 NN denotes folding
T5527 23805-23808 CC denotes and
T5528 23809-23818 NN denotes transport
T5529 23818-23820 , denotes ,
T5530 23820-23822 RB denotes as
T5531 23828-23830 IN denotes as
T5532 23823-23827 RB denotes well
T5533 23831-23833 IN denotes in
T5534 23834-23839 JJ denotes other
T5535 23840-23849 NNS denotes processes
T5536 23850-23854 WDT denotes that
T5537 23865-23873 VB denotes envision
T5538 23855-23858 PRP denotes one
T5539 23859-23864 MD denotes might
T5540 23874-23879 MD denotes would
T5541 23880-23882 VB denotes be
T5542 23883-23892 JJ denotes important
T5543 23893-23895 IN denotes in
T5544 23896-23904 VBG denotes building
T5545 23905-23906 DT denotes a
T5546 23907-23916 NN denotes structure
T5547 23917-23921 JJ denotes such
T5548 23922-23924 IN denotes as
T5549 23925-23928 DT denotes the
T5550 23935-23942 NN denotes segment
T5551 23929-23934 JJ denotes outer
T5552 23942-23943 . denotes .
T5553 23943-24148 sentence denotes In situ hybridization using probes from this collection of genes has revealed that some of them have their RNA localized to the inner segment, a finding typical for proteins targeted to the outer segment.
T5554 23944-23946 FW denotes In
T5555 23947-23951 FW denotes situ
T5556 23952-23965 NN denotes hybridization
T5557 24013-24021 VBN denotes revealed
T5558 23966-23971 VBG denotes using
T5559 23972-23978 NNS denotes probes
T5560 23979-23983 IN denotes from
T5561 23984-23988 DT denotes this
T5562 23989-23999 NN denotes collection
T5563 24000-24002 IN denotes of
T5564 24003-24008 NNS denotes genes
T5565 24009-24012 VBZ denotes has
T5566 24022-24026 IN denotes that
T5567 24040-24044 VBP denotes have
T5568 24027-24031 DT denotes some
T5569 24032-24034 IN denotes of
T5570 24035-24039 PRP denotes them
T5571 24045-24050 PRP$ denotes their
T5572 24051-24054 NN denotes RNA
T5573 24055-24064 VBN denotes localized
T5574 24065-24067 IN denotes to
T5575 24068-24071 DT denotes the
T5576 24078-24085 NN denotes segment
T5577 24072-24077 JJ denotes inner
T5578 24085-24087 , denotes ,
T5579 24087-24088 DT denotes a
T5580 24089-24096 NN denotes finding
T5581 24097-24104 JJ denotes typical
T5582 24105-24108 IN denotes for
T5583 24109-24117 NN denotes proteins
T5584 24118-24126 VBN denotes targeted
T5585 24127-24129 IN denotes to
T5586 24130-24133 DT denotes the
T5587 24140-24147 NN denotes segment
T5588 24134-24139 JJ denotes outer
T5589 24147-24148 . denotes .
T5590 24148-24248 sentence denotes Future analyses of the function of these genes might reveal their role in outer segment biogenesis.
T5591 24149-24155 JJ denotes Future
T5592 24156-24164 NNS denotes analyses
T5593 24202-24208 VB denotes reveal
T5594 24165-24167 IN denotes of
T5595 24168-24171 DT denotes the
T5596 24172-24180 NN denotes function
T5597 24181-24183 IN denotes of
T5598 24184-24189 DT denotes these
T5599 24190-24195 NNS denotes genes
T5600 24196-24201 MD denotes might
T5601 24209-24214 PRP$ denotes their
T5602 24215-24219 NN denotes role
T5603 24220-24222 IN denotes in
T5604 24223-24228 JJ denotes outer
T5605 24229-24236 NN denotes segment
T5606 24237-24247 NN denotes biogenesis
T5607 24247-24248 . denotes .
T5608 24248-24341 sentence denotes Finally, polarization of photoreceptors was found to be largely intact, as was ciliogenesis.
T5609 24249-24256 RB denotes Finally
T5610 24293-24298 VBN denotes found
T5611 24256-24258 , denotes ,
T5612 24258-24270 NN denotes polarization
T5613 24271-24273 IN denotes of
T5614 24274-24288 NNS denotes photoreceptors
T5615 24289-24292 VBD denotes was
T5616 24299-24301 TO denotes to
T5617 24302-24304 VB denotes be
T5618 24305-24312 RB denotes largely
T5619 24313-24319 JJ denotes intact
T5620 24319-24321 , denotes ,
T5621 24321-24323 IN denotes as
T5622 24324-24327 VBD denotes was
T5623 24328-24340 NN denotes ciliogenesis
T5624 24340-24341 . denotes .
T5625 24341-24452 sentence denotes Another LCA gene, CRB1, and a related gene CRB3, have been implicated in ciliogenesis in in vitro models [46].
T5626 24342-24349 DT denotes Another
T5627 24354-24358 NN denotes gene
T5628 24350-24353 NN denotes LCA
T5629 24401-24411 VBN denotes implicated
T5630 24358-24360 , denotes ,
T5631 24360-24364 NN denotes CRB1
T5632 24364-24366 , denotes ,
T5633 24366-24369 CC denotes and
T5634 24370-24371 DT denotes a
T5635 24380-24384 NN denotes gene
T5636 24372-24379 JJ denotes related
T5637 24385-24389 NN denotes CRB3
T5638 24389-24391 , denotes ,
T5639 24391-24395 VBP denotes have
T5640 24396-24400 VBN denotes been
T5641 24412-24414 IN denotes in
T5642 24415-24427 NN denotes ciliogenesis
T5643 24428-24430 IN denotes in
T5644 24431-24433 FW denotes in
T5645 24434-24439 FW denotes vitro
T5646 24440-24446 NNS denotes models
T5647 24447-24448 -LRB- denotes [
T5648 24448-24450 CD denotes 46
T5649 24450-24451 -RRB- denotes ]
T5650 24451-24452 . denotes .
T5651 24452-24551 sentence denotes The Drosophila homologue of CRB1, Crumbs, has been implicated in photoreceptor morphogenesis [47].
T5652 24453-24456 DT denotes The
T5653 24468-24477 NN denotes homologue
T5654 24457-24467 NNP denotes Drosophila
T5655 24504-24514 VBN denotes implicated
T5656 24478-24480 IN denotes of
T5657 24481-24485 NN denotes CRB1
T5658 24485-24487 , denotes ,
T5659 24487-24493 NNP denotes Crumbs
T5660 24493-24495 , denotes ,
T5661 24495-24498 VBZ denotes has
T5662 24499-24503 VBN denotes been
T5663 24515-24517 IN denotes in
T5664 24518-24531 NN denotes photoreceptor
T5665 24532-24545 NN denotes morphogenesis
T5666 24546-24547 -LRB- denotes [
T5667 24547-24549 CD denotes 47
T5668 24549-24550 -RRB- denotes ]
T5669 24550-24551 . denotes .
T5670 24551-24783 sentence denotes However, the spontaneously occurring mouse mutant in CRB1, the Rd8 mouse, develops shortened outer segments that subsequently degenerate [48], suggesting that photoreceptor polarization and synaptogenesis are intact in this mutant.
T5671 24552-24559 RB denotes However
T5672 24626-24634 VBZ denotes develops
T5673 24559-24561 , denotes ,
T5674 24561-24564 DT denotes the
T5675 24595-24601 NN denotes mutant
T5676 24565-24578 RB denotes spontaneously
T5677 24579-24588 VBG denotes occurring
T5678 24589-24594 NN denotes mouse
T5679 24602-24604 IN denotes in
T5680 24605-24609 NN denotes CRB1
T5681 24609-24611 , denotes ,
T5682 24611-24614 DT denotes the
T5683 24619-24624 NN denotes mouse
T5684 24615-24618 NN denotes Rd8
T5685 24624-24626 , denotes ,
T5686 24635-24644 VBN denotes shortened
T5687 24651-24659 NNS denotes segments
T5688 24645-24650 JJ denotes outer
T5689 24660-24664 WDT denotes that
T5690 24678-24688 VBP denotes degenerate
T5691 24665-24677 RB denotes subsequently
T5692 24689-24690 -LRB- denotes [
T5693 24690-24692 CD denotes 48
T5694 24692-24693 -RRB- denotes ]
T5695 24693-24695 , denotes ,
T5696 24695-24705 VBG denotes suggesting
T5697 24706-24710 IN denotes that
T5698 24757-24760 VBP denotes are
T5699 24711-24724 NN denotes photoreceptor
T5700 24725-24737 NN denotes polarization
T5701 24738-24741 CC denotes and
T5702 24742-24756 NN denotes synaptogenesis
T5703 24761-24767 JJ denotes intact
T5704 24768-24770 IN denotes in
T5705 24771-24775 DT denotes this
T5706 24776-24782 NN denotes mutant
T5707 24782-24783 . denotes .
T5708 24783-24923 sentence denotes While CRB1 and Crx have been both linked to LCA, further work is necessary to determine if their function is linked in retinal development.
T5709 24784-24789 IN denotes While
T5710 24818-24824 VBN denotes linked
T5711 24790-24794 NN denotes CRB1
T5712 24795-24798 CC denotes and
T5713 24799-24802 NN denotes Crx
T5714 24803-24807 VBP denotes have
T5715 24808-24812 VBN denotes been
T5716 24813-24817 RB denotes both
T5717 24846-24848 VBZ denotes is
T5718 24825-24827 IN denotes to
T5719 24828-24831 NN denotes LCA
T5720 24831-24833 , denotes ,
T5721 24833-24840 JJ denotes further
T5722 24841-24845 NN denotes work
T5723 24849-24858 JJ denotes necessary
T5724 24859-24861 TO denotes to
T5725 24862-24871 VB denotes determine
T5726 24872-24874 IN denotes if
T5727 24893-24899 VBN denotes linked
T5728 24875-24880 PRP$ denotes their
T5729 24881-24889 NN denotes function
T5730 24890-24892 VBZ denotes is
T5731 24900-24902 IN denotes in
T5732 24903-24910 JJ denotes retinal
T5733 24911-24922 NN denotes development
T5734 24922-24923 . denotes .
T6165 24925-24939 NN denotes Synaptogenesis
T6166 24943-24952 VBN denotes perturbed
T6167 24940-24942 VBZ denotes is
T6168 24953-24955 IN denotes in
T6169 24956-24959 NN denotes Crx
T6170 24963-24977 NNS denotes photoreceptors
T6171 24959-24960 SYM denotes -
T6172 24960-24961 HYPH denotes /
T6173 24961-24962 SYM denotes -
T6174 24977-25079 sentence denotes The Crx-/- mouse demonstrates the most severe abnormality of photoreceptor synapses reported to date.
T6175 24978-24981 DT denotes The
T6176 24989-24994 NN denotes mouse
T6177 24982-24985 NN denotes Crx
T6178 24985-24986 SYM denotes -
T6179 24986-24987 HYPH denotes /
T6180 24987-24988 SYM denotes -
T6181 24995-25007 VBZ denotes demonstrates
T6182 25008-25011 DT denotes the
T6183 25024-25035 NN denotes abnormality
T6184 25012-25016 RBS denotes most
T6185 25017-25023 JJ denotes severe
T6186 25036-25038 IN denotes of
T6187 25039-25052 NN denotes photoreceptor
T6188 25053-25061 NNS denotes synapses
T6189 25062-25070 VBN denotes reported
T6190 25071-25073 IN denotes to
T6191 25074-25078 NN denotes date
T6192 25078-25079 . denotes .
T6193 25079-25218 sentence denotes The peripherin-/- mouse develops a normal complement of photoreceptor terminals which then degenerate as the photoreceptors are lost [30].
T6194 25080-25083 DT denotes The
T6195 25098-25103 NN denotes mouse
T6196 25084-25094 NN denotes peripherin
T6197 25094-25095 SYM denotes -
T6198 25095-25096 HYPH denotes /
T6199 25096-25097 SYM denotes -
T6200 25104-25112 VBZ denotes develops
T6201 25113-25114 DT denotes a
T6202 25122-25132 NN denotes complement
T6203 25115-25121 JJ denotes normal
T6204 25133-25135 IN denotes of
T6205 25136-25149 NN denotes photoreceptor
T6206 25150-25159 NNS denotes terminals
T6207 25160-25165 WDT denotes which
T6208 25171-25181 VBP denotes degenerate
T6209 25166-25170 RB denotes then
T6210 25182-25184 IN denotes as
T6211 25208-25212 VBN denotes lost
T6212 25185-25188 DT denotes the
T6213 25189-25203 NNS denotes photoreceptors
T6214 25204-25207 VBP denotes are
T6215 25213-25214 -LRB- denotes [
T6216 25214-25216 CD denotes 30
T6217 25216-25217 -RRB- denotes ]
T6218 25217-25218 . denotes .
T6219 25218-25392 sentence denotes Also, similarly in rhodopsin (Rho) and cyclic nucleotide-gated channel, alpha-3 (CNGA3) double knockout mice (Rho-/-, CNGA3-/-), synapses are reported to form normally [49].
T6220 25219-25223 RB denotes Also
T6221 25361-25369 VBN denotes reported
T6222 25223-25225 , denotes ,
T6223 25225-25234 RB denotes similarly
T6224 25235-25237 IN denotes in
T6225 25238-25247 NN denotes rhodopsin
T6226 25248-25249 -LRB- denotes (
T6227 25249-25252 NN denotes Rho
T6228 25252-25253 -RRB- denotes )
T6229 25254-25257 CC denotes and
T6230 25258-25264 JJ denotes cyclic
T6231 25282-25289 NN denotes channel
T6232 25265-25275 NN denotes nucleotide
T6233 25276-25281 VBN denotes gated
T6234 25275-25276 HYPH denotes -
T6235 25291-25296 NN denotes alpha
T6236 25289-25291 , denotes ,
T6237 25323-25327 NNS denotes mice
T6238 25296-25297 HYPH denotes -
T6239 25297-25298 CD denotes 3
T6240 25299-25300 -LRB- denotes (
T6241 25300-25305 NN denotes CNGA3
T6242 25305-25306 -RRB- denotes )
T6243 25307-25313 JJ denotes double
T6244 25314-25322 NN denotes knockout
T6245 25328-25329 -LRB- denotes (
T6246 25329-25332 NN denotes Rho
T6247 25332-25333 SYM denotes -
T6248 25333-25334 HYPH denotes /
T6249 25334-25335 SYM denotes -
T6250 25335-25337 , denotes ,
T6251 25337-25342 NN denotes CNGA3
T6252 25342-25343 SYM denotes -
T6253 25343-25344 HYPH denotes /
T6254 25344-25345 SYM denotes -
T6255 25345-25346 -RRB- denotes )
T6256 25346-25348 , denotes ,
T6257 25348-25356 NNS denotes synapses
T6258 25357-25360 VBP denotes are
T6259 25370-25372 TO denotes to
T6260 25373-25377 VB denotes form
T6261 25378-25386 RB denotes normally
T6262 25387-25388 -LRB- denotes [
T6263 25388-25390 CD denotes 49
T6264 25390-25391 -RRB- denotes ]
T6265 25391-25392 . denotes .
T6266 25392-25510 sentence denotes These observations demonstrate that photoreceptor synaptogenesis can occur in the absence of outer segment formation.
T6267 25393-25398 DT denotes These
T6268 25399-25411 NNS denotes observations
T6269 25412-25423 VBP denotes demonstrate
T6270 25424-25428 IN denotes that
T6271 25462-25467 VB denotes occur
T6272 25429-25442 NN denotes photoreceptor
T6273 25443-25457 NN denotes synaptogenesis
T6274 25458-25461 MD denotes can
T6275 25468-25470 IN denotes in
T6276 25471-25474 DT denotes the
T6277 25475-25482 NN denotes absence
T6278 25483-25485 IN denotes of
T6279 25486-25491 JJ denotes outer
T6280 25492-25499 NN denotes segment
T6281 25500-25509 NN denotes formation
T6282 25509-25510 . denotes .
T6283 25510-25749 sentence denotes In keeping with this observation is the fact that some electroretinogram activity is present in peripherin-/- mice, suggesting that minimal phototransduction is present in these mice, enough to drive activity at the photoreceptor synapse.
T6284 25511-25513 IN denotes In
T6285 25544-25546 VBZ denotes is
T6286 25514-25521 VBG denotes keeping
T6287 25522-25526 IN denotes with
T6288 25527-25531 DT denotes this
T6289 25532-25543 NN denotes observation
T6290 25547-25550 DT denotes the
T6291 25551-25555 NN denotes fact
T6292 25556-25560 IN denotes that
T6293 25593-25595 VBZ denotes is
T6294 25561-25565 DT denotes some
T6295 25584-25592 NN denotes activity
T6296 25566-25583 NN denotes electroretinogram
T6297 25596-25603 JJ denotes present
T6298 25604-25606 IN denotes in
T6299 25607-25617 NN denotes peripherin
T6300 25621-25625 NNS denotes mice
T6301 25617-25618 SYM denotes -
T6302 25618-25619 HYPH denotes /
T6303 25619-25620 SYM denotes -
T6304 25625-25627 , denotes ,
T6305 25627-25637 VBG denotes suggesting
T6306 25638-25642 IN denotes that
T6307 25669-25671 VBZ denotes is
T6308 25643-25650 JJ denotes minimal
T6309 25651-25668 NN denotes phototransduction
T6310 25672-25679 JJ denotes present
T6311 25680-25682 IN denotes in
T6312 25683-25688 DT denotes these
T6313 25689-25693 NNS denotes mice
T6314 25693-25695 , denotes ,
T6315 25695-25701 RB denotes enough
T6316 25702-25704 TO denotes to
T6317 25705-25710 VB denotes drive
T6318 25711-25719 NN denotes activity
T6319 25720-25722 IN denotes at
T6320 25723-25726 DT denotes the
T6321 25741-25748 NN denotes synapse
T6322 25727-25740 NN denotes photoreceptor
T6323 25748-25749 . denotes .
T6324 25749-26046 sentence denotes In vitro studies wherein synapse elements are formed in the absence of proper outer segment development and, therefore, possible absence of light-dependent photoreceptor activity, have indicated the independence of phototransduction and synapse formation, at least for the initial stages [50,51].
T6325 25750-25752 FW denotes In
T6326 25753-25758 FW denotes vitro
T6327 25759-25766 NNS denotes studies
T6328 25935-25944 VBN denotes indicated
T6329 25767-25774 IN denotes wherein
T6330 25796-25802 VBN denotes formed
T6331 25775-25782 NN denotes synapse
T6332 25783-25791 NNS denotes elements
T6333 25792-25795 VBP denotes are
T6334 25803-25805 IN denotes in
T6335 25806-25809 DT denotes the
T6336 25810-25817 NN denotes absence
T6337 25818-25820 IN denotes of
T6338 25821-25827 JJ denotes proper
T6339 25842-25853 NN denotes development
T6340 25828-25833 JJ denotes outer
T6341 25834-25841 NN denotes segment
T6342 25854-25857 CC denotes and
T6343 25857-25859 , denotes ,
T6344 25859-25868 RB denotes therefore
T6345 25879-25886 NN denotes absence
T6346 25868-25870 , denotes ,
T6347 25870-25878 JJ denotes possible
T6348 25887-25889 IN denotes of
T6349 25890-25895 NN denotes light
T6350 25896-25905 JJ denotes dependent
T6351 25895-25896 HYPH denotes -
T6352 25920-25928 NN denotes activity
T6353 25906-25919 NN denotes photoreceptor
T6354 25928-25930 , denotes ,
T6355 25930-25934 VBP denotes have
T6356 25945-25948 DT denotes the
T6357 25949-25961 NN denotes independence
T6358 25962-25964 IN denotes of
T6359 25965-25982 NN denotes phototransduction
T6360 25983-25986 CC denotes and
T6361 25987-25994 NN denotes synapse
T6362 25995-26004 NN denotes formation
T6363 26004-26006 , denotes ,
T6364 26006-26008 RB denotes at
T6365 26009-26014 RBS denotes least
T6366 26015-26018 IN denotes for
T6367 26019-26022 DT denotes the
T6368 26031-26037 NNS denotes stages
T6369 26023-26030 JJ denotes initial
T6370 26038-26039 -LRB- denotes [
T6371 26042-26044 CD denotes 51
T6372 26039-26041 CD denotes 50
T6373 26041-26042 , denotes ,
T6374 26044-26045 -RRB- denotes ]
T6375 26045-26046 . denotes .
T6376 26046-26200 sentence denotes These data then suggest that the fact that the Crx-/- photoreceptors do not have proper synaptic endings is not due to a lack of outer segment formation.
T6377 26047-26052 DT denotes These
T6378 26053-26057 NNS denotes data
T6379 26063-26070 VBP denotes suggest
T6380 26058-26062 RB denotes then
T6381 26071-26075 IN denotes that
T6382 26152-26154 VBZ denotes is
T6383 26076-26079 DT denotes the
T6384 26080-26084 NN denotes fact
T6385 26085-26089 IN denotes that
T6386 26123-26127 VB denotes have
T6387 26090-26093 DT denotes the
T6388 26101-26115 NNS denotes photoreceptors
T6389 26094-26097 NN denotes Crx
T6390 26097-26098 SYM denotes -
T6391 26098-26099 HYPH denotes /
T6392 26099-26100 SYM denotes -
T6393 26116-26118 VBP denotes do
T6394 26119-26122 RB denotes not
T6395 26128-26134 JJ denotes proper
T6396 26144-26151 NNS denotes endings
T6397 26135-26143 JJ denotes synaptic
T6398 26155-26158 RB denotes not
T6399 26159-26162 IN denotes due
T6400 26163-26165 IN denotes to
T6401 26166-26167 DT denotes a
T6402 26168-26172 NN denotes lack
T6403 26173-26175 IN denotes of
T6404 26176-26181 JJ denotes outer
T6405 26182-26189 NN denotes segment
T6406 26190-26199 NN denotes formation
T6407 26199-26200 . denotes .
T6408 26200-26367 sentence denotes A more likely explanation is that Crx plays a role in photoreceptor synapse formation, perhaps by regulating directly, or indirectly, important genes in this process.
T6409 26201-26202 DT denotes A
T6410 26215-26226 NN denotes explanation
T6411 26203-26207 RBR denotes more
T6412 26208-26214 JJ denotes likely
T6413 26227-26229 VBZ denotes is
T6414 26230-26234 IN denotes that
T6415 26239-26244 VBZ denotes plays
T6416 26235-26238 NN denotes Crx
T6417 26245-26246 DT denotes a
T6418 26247-26251 NN denotes role
T6419 26252-26254 IN denotes in
T6420 26255-26268 NN denotes photoreceptor
T6421 26269-26276 NN denotes synapse
T6422 26277-26286 NN denotes formation
T6423 26286-26288 , denotes ,
T6424 26288-26295 RB denotes perhaps
T6425 26296-26298 IN denotes by
T6426 26299-26309 VBG denotes regulating
T6427 26310-26318 RB denotes directly
T6428 26318-26320 , denotes ,
T6429 26320-26322 CC denotes or
T6430 26323-26333 RB denotes indirectly
T6431 26333-26335 , denotes ,
T6432 26335-26344 JJ denotes important
T6433 26345-26350 NNS denotes genes
T6434 26351-26353 IN denotes in
T6435 26354-26358 DT denotes this
T6436 26359-26366 NN denotes process
T6437 26366-26367 . denotes .
T6438 26367-26615 sentence denotes Using immunohistochemistry, we examined the expression of common pre-synaptic terminal proteins, including KIF3a, SV2, and synaptophysin, and were unable to observe qualitative differences between Crx-/- and control tissue at P14 (data not shown).
T6439 26368-26373 VBG denotes Using
T6440 26399-26407 VBD denotes examined
T6441 26374-26394 NN denotes immunohistochemistry
T6442 26394-26396 , denotes ,
T6443 26396-26398 PRP denotes we
T6444 26408-26411 DT denotes the
T6445 26412-26422 NN denotes expression
T6446 26423-26425 IN denotes of
T6447 26426-26432 JJ denotes common
T6448 26455-26463 NN denotes proteins
T6449 26433-26445 JJ denotes pre-synaptic
T6450 26446-26454 JJ denotes terminal
T6451 26463-26465 , denotes ,
T6452 26465-26474 VBG denotes including
T6453 26475-26480 NN denotes KIF3a
T6454 26480-26482 , denotes ,
T6455 26482-26485 NN denotes SV2
T6456 26485-26487 , denotes ,
T6457 26487-26490 CC denotes and
T6458 26491-26504 NN denotes synaptophysin
T6459 26504-26506 , denotes ,
T6460 26506-26509 CC denotes and
T6461 26510-26514 VBD denotes were
T6462 26515-26521 JJ denotes unable
T6463 26522-26524 TO denotes to
T6464 26525-26532 VB denotes observe
T6465 26533-26544 JJ denotes qualitative
T6466 26545-26556 NNS denotes differences
T6467 26557-26564 IN denotes between
T6468 26565-26568 NN denotes Crx
T6469 26584-26590 NN denotes tissue
T6470 26568-26569 SYM denotes -
T6471 26569-26570 HYPH denotes /
T6472 26570-26571 SYM denotes -
T6473 26572-26575 CC denotes and
T6474 26576-26583 NN denotes control
T6475 26591-26593 IN denotes at
T6476 26594-26597 NN denotes P14
T6477 26598-26599 -LRB- denotes (
T6478 26608-26613 VBN denotes shown
T6479 26599-26603 NNS denotes data
T6480 26604-26607 RB denotes not
T6481 26613-26614 -RRB- denotes )
T6482 26614-26615 . denotes .
T6483 26615-26823 sentence denotes Examination of their RNA levels by SAGE showed no significant difference for all 3 genes, though very few tags were recovered from these genes and thus the analysis of RNA levels may not be significant [35].
T6484 26616-26627 NN denotes Examination
T6485 26656-26662 VBD denotes showed
T6486 26628-26630 IN denotes of
T6487 26631-26636 PRP$ denotes their
T6488 26641-26647 NNS denotes levels
T6489 26637-26640 NN denotes RNA
T6490 26648-26650 IN denotes by
T6491 26651-26655 NN denotes SAGE
T6492 26663-26665 DT denotes no
T6493 26678-26688 NN denotes difference
T6494 26666-26677 JJ denotes significant
T6495 26689-26692 IN denotes for
T6496 26693-26696 DT denotes all
T6497 26699-26704 NNS denotes genes
T6498 26697-26698 CD denotes 3
T6499 26704-26706 , denotes ,
T6500 26706-26712 IN denotes though
T6501 26732-26741 VBN denotes recovered
T6502 26713-26717 RB denotes very
T6503 26718-26721 JJ denotes few
T6504 26722-26726 NNS denotes tags
T6505 26727-26731 VBD denotes were
T6506 26742-26746 IN denotes from
T6507 26747-26752 DT denotes these
T6508 26753-26758 NNS denotes genes
T6509 26759-26762 CC denotes and
T6510 26763-26767 RB denotes thus
T6511 26803-26805 VB denotes be
T6512 26768-26771 DT denotes the
T6513 26772-26780 NN denotes analysis
T6514 26781-26783 IN denotes of
T6515 26784-26787 NN denotes RNA
T6516 26788-26794 NNS denotes levels
T6517 26795-26798 MD denotes may
T6518 26799-26802 RB denotes not
T6519 26806-26817 JJ denotes significant
T6520 26818-26819 -LRB- denotes [
T6521 26819-26821 CD denotes 35
T6522 26821-26822 -RRB- denotes ]
T6523 26822-26823 . denotes .
T6524 26823-27035 sentence denotes However, since other genes expressed in photoreceptors were significantly altered in their expression level in the Crx-/- mouse, there are many candidates that could be important for photoreceptor morphogenesis.
T6525 26824-26831 RB denotes However
T6526 26959-26962 VBP denotes are
T6527 26831-26833 , denotes ,
T6528 26833-26838 IN denotes since
T6529 26898-26905 VBN denotes altered
T6530 26839-26844 JJ denotes other
T6531 26845-26850 NNS denotes genes
T6532 26851-26860 VBN denotes expressed
T6533 26861-26863 IN denotes in
T6534 26864-26878 NNS denotes photoreceptors
T6535 26879-26883 VBD denotes were
T6536 26884-26897 RB denotes significantly
T6537 26906-26908 IN denotes in
T6538 26909-26914 PRP$ denotes their
T6539 26926-26931 NN denotes level
T6540 26915-26925 NN denotes expression
T6541 26932-26934 IN denotes in
T6542 26935-26938 DT denotes the
T6543 26946-26951 NN denotes mouse
T6544 26939-26942 NN denotes Crx
T6545 26942-26943 SYM denotes -
T6546 26943-26944 HYPH denotes /
T6547 26944-26945 SYM denotes -
T6548 26951-26953 , denotes ,
T6549 26953-26958 EX denotes there
T6550 26963-26967 JJ denotes many
T6551 26968-26978 NNS denotes candidates
T6552 26979-26983 WDT denotes that
T6553 26990-26992 VB denotes be
T6554 26984-26989 MD denotes could
T6555 26993-27002 JJ denotes important
T6556 27003-27006 IN denotes for
T6557 27007-27020 NN denotes photoreceptor
T6558 27021-27034 NN denotes morphogenesis
T6559 27034-27035 . denotes .
T6560 27035-27307 sentence denotes Tags from three genes from proteins expressed in photoreceptor terminals were found to be decreased in a statistically significant fashion, namely the HGF-regulated tyrosine kinase substrate, the CRIPT protein, and synaptotagmin 1 (Blackshaw and Cepko, unpublished data).
T6561 27036-27040 NNS denotes Tags
T6562 27114-27119 VBN denotes found
T6563 27041-27045 IN denotes from
T6564 27046-27051 CD denotes three
T6565 27052-27057 NNS denotes genes
T6566 27058-27062 IN denotes from
T6567 27063-27071 NN denotes proteins
T6568 27072-27081 VBN denotes expressed
T6569 27082-27084 IN denotes in
T6570 27085-27098 NN denotes photoreceptor
T6571 27099-27108 NNS denotes terminals
T6572 27109-27113 VBD denotes were
T6573 27120-27122 TO denotes to
T6574 27126-27135 VBN denotes decreased
T6575 27123-27125 VB denotes be
T6576 27136-27138 IN denotes in
T6577 27139-27140 DT denotes a
T6578 27167-27174 NN denotes fashion
T6579 27141-27154 RB denotes statistically
T6580 27155-27166 JJ denotes significant
T6581 27174-27176 , denotes ,
T6582 27176-27182 RB denotes namely
T6583 27217-27226 NN denotes substrate
T6584 27183-27186 DT denotes the
T6585 27187-27190 NN denotes HGF
T6586 27191-27200 VBN denotes regulated
T6587 27190-27191 HYPH denotes -
T6588 27201-27209 NN denotes tyrosine
T6589 27210-27216 NN denotes kinase
T6590 27226-27228 , denotes ,
T6591 27228-27231 DT denotes the
T6592 27238-27245 NN denotes protein
T6593 27232-27237 NN denotes CRIPT
T6594 27245-27247 , denotes ,
T6595 27247-27250 CC denotes and
T6596 27251-27264 NN denotes synaptotagmin
T6597 27265-27266 CD denotes 1
T6598 27267-27268 -LRB- denotes (
T6599 27268-27277 NNP denotes Blackshaw
T6600 27278-27281 CC denotes and
T6601 27282-27287 NNP denotes Cepko
T6602 27287-27289 , denotes ,
T6603 27289-27300 JJ denotes unpublished
T6604 27301-27305 NNS denotes data
T6605 27305-27306 -RRB- denotes )
T6606 27306-27307 . denotes .
T6607 27307-27514 sentence denotes An example of a gene that was increased in the Crx-/- retina is HRG4 (a homologue of the C. elegans Unc119 gene) (Blackshaw and Cepko, unpublished data) which encodes a component of the ribbon synapse [33].
T6608 27308-27310 DT denotes An
T6609 27311-27318 NN denotes example
T6610 27369-27371 VBZ denotes is
T6611 27319-27321 IN denotes of
T6612 27322-27323 DT denotes a
T6613 27324-27328 NN denotes gene
T6614 27329-27333 WDT denotes that
T6615 27338-27347 VBN denotes increased
T6616 27334-27337 VBD denotes was
T6617 27348-27350 IN denotes in
T6618 27351-27354 DT denotes the
T6619 27362-27368 NN denotes retina
T6620 27355-27358 NN denotes Crx
T6621 27358-27359 SYM denotes -
T6622 27359-27360 HYPH denotes /
T6623 27360-27361 SYM denotes -
T6624 27372-27376 NN denotes HRG4
T6625 27377-27378 -LRB- denotes (
T6626 27378-27379 DT denotes a
T6627 27380-27389 NN denotes homologue
T6628 27390-27392 IN denotes of
T6629 27393-27396 DT denotes the
T6630 27415-27419 NN denotes gene
T6631 27397-27399 NNP denotes C.
T6632 27400-27407 NNP denotes elegans
T6633 27408-27414 NN denotes Unc119
T6634 27419-27420 -RRB- denotes )
T6635 27421-27422 -LRB- denotes (
T6636 27422-27431 NNP denotes Blackshaw
T6637 27432-27435 CC denotes and
T6638 27436-27441 NNP denotes Cepko
T6639 27441-27443 , denotes ,
T6640 27443-27454 JJ denotes unpublished
T6641 27455-27459 NNS denotes data
T6642 27459-27460 -RRB- denotes )
T6643 27461-27466 WDT denotes which
T6644 27467-27474 VBZ denotes encodes
T6645 27475-27476 DT denotes a
T6646 27477-27486 NN denotes component
T6647 27487-27489 IN denotes of
T6648 27490-27493 DT denotes the
T6649 27501-27508 NN denotes synapse
T6650 27494-27500 NN denotes ribbon
T6651 27509-27510 -LRB- denotes [
T6652 27510-27512 CD denotes 33
T6653 27512-27513 -RRB- denotes ]
T6654 27513-27514 . denotes .
T6655 27514-27615 sentence denotes The fact that it is upregulated might indicate a response to the lack of proper terminal structures.
T6656 27515-27518 DT denotes The
T6657 27519-27523 NN denotes fact
T6658 27553-27561 VB denotes indicate
T6659 27524-27528 IN denotes that
T6660 27535-27546 VBN denotes upregulated
T6661 27529-27531 PRP denotes it
T6662 27532-27534 VBZ denotes is
T6663 27547-27552 MD denotes might
T6664 27562-27563 DT denotes a
T6665 27564-27572 NN denotes response
T6666 27573-27575 IN denotes to
T6667 27576-27579 DT denotes the
T6668 27580-27584 NN denotes lack
T6669 27585-27587 IN denotes of
T6670 27588-27594 JJ denotes proper
T6671 27604-27614 NNS denotes structures
T6672 27595-27603 JJ denotes terminal
T6673 27614-27615 . denotes .
T6674 27615-27811 sentence denotes Several other genes encoding putative cytoskeletal elements also were increased (e.g. microtubule associated protein 4) or decreased (e.g. cofilin 1) in the Crx-/- retina, with P values of <.005.
T6675 27616-27623 JJ denotes Several
T6676 27630-27635 NNS denotes genes
T6677 27624-27629 JJ denotes other
T6678 27686-27695 VBN denotes increased
T6679 27636-27644 VBG denotes encoding
T6680 27645-27653 JJ denotes putative
T6681 27667-27675 NNS denotes elements
T6682 27654-27666 JJ denotes cytoskeletal
T6683 27676-27680 RB denotes also
T6684 27681-27685 VBD denotes were
T6685 27696-27697 -LRB- denotes (
T6686 27725-27732 NN denotes protein
T6687 27697-27701 FW denotes e.g.
T6688 27702-27713 NN denotes microtubule
T6689 27714-27724 VBN denotes associated
T6690 27733-27734 CD denotes 4
T6691 27734-27735 -RRB- denotes )
T6692 27736-27738 CC denotes or
T6693 27739-27748 VBN denotes decreased
T6694 27749-27750 -LRB- denotes (
T6695 27755-27762 NN denotes cofilin
T6696 27750-27754 FW denotes e.g.
T6697 27763-27764 CD denotes 1
T6698 27764-27765 -RRB- denotes )
T6699 27766-27768 IN denotes in
T6700 27769-27772 DT denotes the
T6701 27780-27786 NN denotes retina
T6702 27773-27776 NN denotes Crx
T6703 27776-27777 SYM denotes -
T6704 27777-27778 HYPH denotes /
T6705 27778-27779 SYM denotes -
T6706 27786-27788 , denotes ,
T6707 27788-27792 IN denotes with
T6708 27793-27794 NN denotes P
T6709 27795-27801 NNS denotes values
T6710 27802-27804 IN denotes of
T6711 27805-27806 SYM denotes <
T6712 27806-27810 CD denotes .005
T6713 27810-27811 . denotes .
T6714 27811-28070 sentence denotes It is not known whether any of these genes are involved in building or regulating synaptic structures, but they are now genes that might lead to a better understanding of the construction and function of the relatively unique structure of the ribbon synapse.
T6715 27812-27814 PRP denotes It
T6716 27822-27827 VBN denotes known
T6717 27815-27817 VBZ denotes is
T6718 27818-27821 RB denotes not
T6719 27828-27835 IN denotes whether
T6720 27859-27867 VBN denotes involved
T6721 27836-27839 DT denotes any
T6722 27840-27842 IN denotes of
T6723 27843-27848 DT denotes these
T6724 27849-27854 NNS denotes genes
T6725 27855-27858 VBP denotes are
T6726 27868-27870 IN denotes in
T6727 27871-27879 VBG denotes building
T6728 27880-27882 CC denotes or
T6729 27883-27893 VBG denotes regulating
T6730 27894-27902 JJ denotes synaptic
T6731 27903-27913 NNS denotes structures
T6732 27913-27915 , denotes ,
T6733 27915-27918 CC denotes but
T6734 27919-27923 PRP denotes they
T6735 27924-27927 VBP denotes are
T6736 27928-27931 RB denotes now
T6737 27932-27937 NNS denotes genes
T6738 27938-27942 WDT denotes that
T6739 27949-27953 VB denotes lead
T6740 27943-27948 MD denotes might
T6741 27954-27956 IN denotes to
T6742 27957-27958 DT denotes a
T6743 27966-27979 NN denotes understanding
T6744 27959-27965 JJR denotes better
T6745 27980-27982 IN denotes of
T6746 27983-27986 DT denotes the
T6747 27987-27999 NN denotes construction
T6748 28000-28003 CC denotes and
T6749 28004-28012 NN denotes function
T6750 28013-28015 IN denotes of
T6751 28016-28019 DT denotes the
T6752 28038-28047 NN denotes structure
T6753 28020-28030 RB denotes relatively
T6754 28031-28037 JJ denotes unique
T6755 28048-28050 IN denotes of
T6756 28051-28054 DT denotes the
T6757 28062-28069 NN denotes synapse
T6758 28055-28061 NN denotes ribbon
T6759 28069-28070 . denotes .
T6760 28070-28216 sentence denotes Abnormal photoreceptor terminal formation was noted in a study that examined retinal development in the laminin beta2 chain-deficient mouse [52].
T6761 28071-28079 JJ denotes Abnormal
T6762 28103-28112 NN denotes formation
T6763 28080-28093 NN denotes photoreceptor
T6764 28094-28102 NN denotes terminal
T6765 28117-28122 VBN denotes noted
T6766 28113-28116 VBD denotes was
T6767 28123-28125 IN denotes in
T6768 28126-28127 DT denotes a
T6769 28128-28133 NN denotes study
T6770 28134-28138 WDT denotes that
T6771 28139-28147 VBD denotes examined
T6772 28148-28155 JJ denotes retinal
T6773 28156-28167 NN denotes development
T6774 28168-28170 IN denotes in
T6775 28171-28174 DT denotes the
T6776 28205-28210 NN denotes mouse
T6777 28175-28182 NN denotes laminin
T6778 28189-28194 NN denotes chain
T6779 28183-28188 NN denotes beta2
T6780 28195-28204 JJ denotes deficient
T6781 28194-28195 HYPH denotes -
T6782 28211-28212 -LRB- denotes [
T6783 28212-28214 CD denotes 52
T6784 28214-28215 -RRB- denotes ]
T6785 28215-28216 . denotes .
T6786 28216-28262 sentence denotes Several pathologies were noted in these mice.
T6787 28217-28224 JJ denotes Several
T6788 28225-28236 NNS denotes pathologies
T6789 28242-28247 VBN denotes noted
T6790 28237-28241 VBD denotes were
T6791 28248-28250 IN denotes in
T6792 28251-28256 DT denotes these
T6793 28257-28261 NNS denotes mice
T6794 28261-28262 . denotes .
T6795 28262-28455 sentence denotes First, laminin beta2 chain-deficient mice displayed abnormal outer segment elongation, but a more mild phenotype than that of the Crx-/- mice; the outer segments were reduced by 50% in length.
T6796 28263-28268 RB denotes First
T6797 28305-28314 VBD denotes displayed
T6798 28268-28270 , denotes ,
T6799 28270-28277 NN denotes laminin
T6800 28284-28289 NN denotes chain
T6801 28278-28283 NN denotes beta2
T6802 28290-28299 JJ denotes deficient
T6803 28289-28290 HYPH denotes -
T6804 28300-28304 NNS denotes mice
T6805 28430-28437 VBN denotes reduced
T6806 28315-28323 JJ denotes abnormal
T6807 28338-28348 NN denotes elongation
T6808 28324-28329 JJ denotes outer
T6809 28330-28337 NN denotes segment
T6810 28348-28350 , denotes ,
T6811 28350-28353 CC denotes but
T6812 28354-28355 DT denotes a
T6813 28366-28375 NN denotes phenotype
T6814 28356-28360 RBR denotes more
T6815 28361-28365 JJ denotes mild
T6816 28376-28380 IN denotes than
T6817 28381-28385 DT denotes that
T6818 28386-28388 IN denotes of
T6819 28389-28392 DT denotes the
T6820 28400-28404 NNS denotes mice
T6821 28393-28396 NN denotes Crx
T6822 28396-28397 SYM denotes -
T6823 28397-28398 HYPH denotes /
T6824 28398-28399 SYM denotes -
T6825 28404-28405 : denotes ;
T6826 28406-28409 DT denotes the
T6827 28416-28424 NNS denotes segments
T6828 28410-28415 JJ denotes outer
T6829 28425-28429 VBD denotes were
T6830 28438-28440 IN denotes by
T6831 28441-28443 CD denotes 50
T6832 28443-28444 NN denotes %
T6833 28445-28447 IN denotes in
T6834 28448-28454 NN denotes length
T6835 28454-28455 . denotes .
T6836 28455-28591 sentence denotes Also photoreceptor terminals were perturbed in laminin beta2 mutants, but again the phenotype was more subtle then that of Crx-/- mice.
T6837 28456-28460 RB denotes Also
T6838 28490-28499 VBN denotes perturbed
T6839 28461-28474 NN denotes photoreceptor
T6840 28475-28484 NNS denotes terminals
T6841 28485-28489 VBD denotes were
T6842 28500-28502 IN denotes in
T6843 28503-28510 NN denotes laminin
T6844 28511-28516 NN denotes beta2
T6845 28517-28524 NNS denotes mutants
T6846 28524-28526 , denotes ,
T6847 28526-28529 CC denotes but
T6848 28530-28535 RB denotes again
T6849 28550-28553 VBD denotes was
T6850 28536-28539 DT denotes the
T6851 28540-28549 NN denotes phenotype
T6852 28554-28558 RBR denotes more
T6853 28559-28565 JJ denotes subtle
T6854 28566-28570 IN denotes then
T6855 28571-28575 DT denotes that
T6856 28576-28578 IN denotes of
T6857 28579-28582 NN denotes Crx
T6858 28586-28590 NNS denotes mice
T6859 28582-28583 SYM denotes -
T6860 28583-28584 HYPH denotes /
T6861 28584-28585 SYM denotes -
T6862 28590-28591 . denotes .
T6863 28591-28795 sentence denotes The outer plexiform layer of the beta2-deficient retinas demonstrated only 7% normal invaginating synapses, while the remainder had various pathologies, including floating synaptic ribbons, as seen here.
T6864 28592-28595 DT denotes The
T6865 28612-28617 NN denotes layer
T6866 28596-28601 JJ denotes outer
T6867 28602-28611 NN denotes plexiform
T6868 28649-28661 VBD denotes demonstrated
T6869 28618-28620 IN denotes of
T6870 28621-28624 DT denotes the
T6871 28641-28648 NNS denotes retinas
T6872 28625-28630 NN denotes beta2
T6873 28631-28640 JJ denotes deficient
T6874 28630-28631 HYPH denotes -
T6875 28662-28666 RB denotes only
T6876 28667-28668 CD denotes 7
T6877 28668-28669 NN denotes %
T6878 28690-28698 NNS denotes synapses
T6879 28670-28676 JJ denotes normal
T6880 28677-28689 VBG denotes invaginating
T6881 28698-28700 , denotes ,
T6882 28700-28705 IN denotes while
T6883 28720-28723 VBD denotes had
T6884 28706-28709 DT denotes the
T6885 28710-28719 NN denotes remainder
T6886 28724-28731 JJ denotes various
T6887 28732-28743 NNS denotes pathologies
T6888 28743-28745 , denotes ,
T6889 28745-28754 VBG denotes including
T6890 28755-28763 VBG denotes floating
T6891 28773-28780 NNS denotes ribbons
T6892 28764-28772 JJ denotes synaptic
T6893 28780-28782 , denotes ,
T6894 28782-28784 IN denotes as
T6895 28785-28789 VBN denotes seen
T6896 28790-28794 RB denotes here
T6897 28794-28795 . denotes .
T6898 28795-28907 sentence denotes The mechanistic relationship of these two molecules, if any, in photoreceptor morphogenesis is unknown to date.
T6899 28796-28799 DT denotes The
T6900 28812-28824 NN denotes relationship
T6901 28800-28811 JJ denotes mechanistic
T6902 28888-28890 VBZ denotes is
T6903 28825-28827 IN denotes of
T6904 28828-28833 DT denotes these
T6905 28838-28847 NNS denotes molecules
T6906 28834-28837 CD denotes two
T6907 28847-28849 , denotes ,
T6908 28852-28855 DT denotes any
T6909 28849-28851 IN denotes if
T6910 28855-28857 , denotes ,
T6911 28857-28859 IN denotes in
T6912 28860-28873 NN denotes photoreceptor
T6913 28874-28887 NN denotes morphogenesis
T6914 28891-28898 JJ denotes unknown
T6915 28899-28901 IN denotes to
T6916 28902-28906 NN denotes date
T6917 28906-28907 . denotes .
T6918 28907-29105 sentence denotes The mRNA for laminin beta2 was not detected in the SAGE study of the relative RNA levels in Crx-/- and Crx+/+ and thus we cannot comment on whether the levels of RNA for laminin beta2 were altered.
T6919 28908-28911 DT denotes The
T6920 28912-28916 NN denotes mRNA
T6921 28943-28951 VBN denotes detected
T6922 28917-28920 IN denotes for
T6923 28921-28928 NN denotes laminin
T6924 28929-28934 NN denotes beta2
T6925 28935-28938 VBD denotes was
T6926 28939-28942 RB denotes not
T6927 28952-28954 IN denotes in
T6928 28955-28958 DT denotes the
T6929 28964-28969 NN denotes study
T6930 28959-28963 NN denotes SAGE
T6931 28970-28972 IN denotes of
T6932 28973-28976 DT denotes the
T6933 28990-28996 NNS denotes levels
T6934 28977-28985 JJ denotes relative
T6935 28986-28989 NN denotes RNA
T6936 28997-28999 IN denotes in
T6937 29000-29003 NN denotes Crx
T6938 29003-29004 SYM denotes -
T6939 29004-29005 HYPH denotes /
T6940 29005-29006 SYM denotes -
T6941 29007-29010 CC denotes and
T6942 29011-29014 NN denotes Crx
T6943 29014-29015 SYM denotes +
T6944 29015-29016 HYPH denotes /
T6945 29016-29017 SYM denotes +
T6946 29018-29021 CC denotes and
T6947 29022-29026 RB denotes thus
T6948 29037-29044 VB denotes comment
T6949 29027-29029 PRP denotes we
T6950 29030-29033 MD denotes can
T6951 29033-29036 RB denotes not
T6952 29045-29047 IN denotes on
T6953 29048-29055 IN denotes whether
T6954 29097-29104 VBN denotes altered
T6955 29056-29059 DT denotes the
T6956 29060-29066 NNS denotes levels
T6957 29067-29069 IN denotes of
T6958 29070-29073 NN denotes RNA
T6959 29074-29077 IN denotes for
T6960 29078-29085 NN denotes laminin
T6961 29086-29091 NN denotes beta2
T6962 29092-29096 VBD denotes were
T6963 29104-29105 . denotes .
T7157 29107-29110 NN denotes Crx
T7158 29114-29118 NNS denotes mice
T7159 29110-29111 SYM denotes -
T7160 29111-29112 HYPH denotes /
T7161 29112-29113 SYM denotes -
T7162 29119-29122 VBP denotes are
T7163 29123-29124 DT denotes a
T7164 29125-29130 NN denotes model
T7165 29131-29134 IN denotes for
T7166 29135-29138 NN denotes LCA
T7167 29138-29326 sentence denotes Crx has been implicated in three photoreceptor diseases that result in human blindness, cone-rod dystrophy2, Leber's congenital amaurosis, and retinitis pigmentosa (for review, see [53]).
T7168 29139-29142 NN denotes Crx
T7169 29152-29162 VBN denotes implicated
T7170 29143-29146 VBZ denotes has
T7171 29147-29151 VBN denotes been
T7172 29163-29165 IN denotes in
T7173 29166-29171 CD denotes three
T7174 29186-29194 NNS denotes diseases
T7175 29172-29185 NN denotes photoreceptor
T7176 29195-29199 WDT denotes that
T7177 29200-29206 VBP denotes result
T7178 29207-29209 IN denotes in
T7179 29210-29215 JJ denotes human
T7180 29216-29225 NN denotes blindness
T7181 29225-29227 , denotes ,
T7182 29227-29231 NN denotes cone
T7183 29232-29235 NN denotes rod
T7184 29231-29232 HYPH denotes -
T7185 29236-29246 NN denotes dystrophy2
T7186 29246-29248 , denotes ,
T7187 29248-29253 NNP denotes Leber
T7188 29267-29276 NN denotes amaurosis
T7189 29253-29255 POS denotes 's
T7190 29256-29266 JJ denotes congenital
T7191 29276-29278 , denotes ,
T7192 29278-29281 CC denotes and
T7193 29282-29291 NN denotes retinitis
T7194 29292-29302 NN denotes pigmentosa
T7195 29303-29304 -LRB- denotes (
T7196 29316-29319 VB denotes see
T7197 29304-29307 IN denotes for
T7198 29308-29314 NN denotes review
T7199 29314-29316 , denotes ,
T7200 29320-29321 -LRB- denotes [
T7201 29321-29323 CD denotes 53
T7202 29323-29324 -RRB- denotes ]
T7203 29324-29325 -RRB- denotes )
T7204 29325-29326 . denotes .
T7205 29326-29511 sentence denotes The cone-rod dystrophies (CRDs) are characterized by loss of cone-mediated vision in the first decade of life or later, with concomitant or subsequent loss of rod-mediated vision [54].
T7206 29327-29330 DT denotes The
T7207 29340-29351 NNS denotes dystrophies
T7208 29331-29335 NN denotes cone
T7209 29336-29339 NN denotes rod
T7210 29335-29336 HYPH denotes -
T7211 29363-29376 VBN denotes characterized
T7212 29352-29353 -LRB- denotes (
T7213 29353-29357 NNS denotes CRDs
T7214 29357-29358 -RRB- denotes )
T7215 29359-29362 VBP denotes are
T7216 29377-29379 IN denotes by
T7217 29380-29384 NN denotes loss
T7218 29385-29387 IN denotes of
T7219 29388-29392 NN denotes cone
T7220 29393-29401 VBN denotes mediated
T7221 29392-29393 HYPH denotes -
T7222 29402-29408 NN denotes vision
T7223 29409-29411 IN denotes in
T7224 29412-29415 DT denotes the
T7225 29422-29428 NN denotes decade
T7226 29416-29421 JJ denotes first
T7227 29429-29431 IN denotes of
T7228 29432-29436 NN denotes life
T7229 29437-29439 CC denotes or
T7230 29440-29445 RB denotes later
T7231 29447-29451 IN denotes with
T7232 29445-29447 , denotes ,
T7233 29452-29463 JJ denotes concomitant
T7234 29478-29482 NN denotes loss
T7235 29464-29466 CC denotes or
T7236 29467-29477 JJ denotes subsequent
T7237 29483-29485 IN denotes of
T7238 29486-29489 NN denotes rod
T7239 29490-29498 VBN denotes mediated
T7240 29489-29490 HYPH denotes -
T7241 29499-29505 NN denotes vision
T7242 29506-29507 -LRB- denotes [
T7243 29507-29509 CD denotes 54
T7244 29509-29510 -RRB- denotes ]
T7245 29510-29511 . denotes .
T7246 29511-29618 sentence denotes Conversely, RP is notable for initial loss of rod function, followed by loss of cone-mediated vision [55].
T7247 29512-29522 RB denotes Conversely
T7248 29527-29529 VBZ denotes is
T7249 29522-29524 , denotes ,
T7250 29524-29526 NN denotes RP
T7251 29530-29537 JJ denotes notable
T7252 29538-29541 IN denotes for
T7253 29542-29549 JJ denotes initial
T7254 29550-29554 NN denotes loss
T7255 29555-29557 IN denotes of
T7256 29558-29561 NN denotes rod
T7257 29562-29570 NN denotes function
T7258 29570-29572 , denotes ,
T7259 29572-29580 VBN denotes followed
T7260 29581-29583 IN denotes by
T7261 29584-29588 NN denotes loss
T7262 29589-29591 IN denotes of
T7263 29592-29596 NN denotes cone
T7264 29597-29605 VBN denotes mediated
T7265 29596-29597 HYPH denotes -
T7266 29606-29612 NN denotes vision
T7267 29613-29614 -LRB- denotes [
T7268 29614-29616 CD denotes 55
T7269 29616-29617 -RRB- denotes ]
T7270 29617-29618 . denotes .
T7271 29618-29808 sentence denotes The majority of known genes responsible for human genetic blindness, encode proteins expressed almost exclusively, or exclusively, in photoreceptors, particularly in the outer segment [35].
T7272 29619-29622 DT denotes The
T7273 29623-29631 NN denotes majority
T7274 29688-29694 VBP denotes encode
T7275 29632-29634 IN denotes of
T7276 29635-29640 JJ denotes known
T7277 29641-29646 NNS denotes genes
T7278 29647-29658 JJ denotes responsible
T7279 29659-29662 IN denotes for
T7280 29663-29668 JJ denotes human
T7281 29677-29686 NN denotes blindness
T7282 29669-29676 JJ denotes genetic
T7283 29686-29688 , denotes ,
T7284 29695-29703 NN denotes proteins
T7285 29704-29713 VBN denotes expressed
T7286 29714-29720 RB denotes almost
T7287 29721-29732 RB denotes exclusively
T7288 29750-29752 IN denotes in
T7289 29732-29734 , denotes ,
T7290 29734-29736 CC denotes or
T7291 29737-29748 RB denotes exclusively
T7292 29748-29750 , denotes ,
T7293 29753-29767 NNS denotes photoreceptors
T7294 29767-29769 , denotes ,
T7295 29769-29781 RB denotes particularly
T7296 29782-29784 IN denotes in
T7297 29785-29788 DT denotes the
T7298 29795-29802 NN denotes segment
T7299 29789-29794 JJ denotes outer
T7300 29803-29804 -LRB- denotes [
T7301 29804-29806 CD denotes 35
T7302 29806-29807 -RRB- denotes ]
T7303 29807-29808 . denotes .
T7304 29808-29894 sentence denotes Many of these proteins are required for phototransduction or outer segment structure.
T7305 29809-29813 JJ denotes Many
T7306 29836-29844 VBN denotes required
T7307 29814-29816 IN denotes of
T7308 29817-29822 DT denotes these
T7309 29823-29831 NN denotes proteins
T7310 29832-29835 VBP denotes are
T7311 29845-29848 IN denotes for
T7312 29849-29866 NN denotes phototransduction
T7313 29867-29869 CC denotes or
T7314 29870-29875 JJ denotes outer
T7315 29876-29883 NN denotes segment
T7316 29884-29893 NN denotes structure
T7317 29893-29894 . denotes .
T7318 29894-30028 sentence denotes The mechanisms whereby mutations in rod-specific genes, such as rhodopsin, lead eventually to cone degeneration in RP remain obscure.
T7319 29895-29898 DT denotes The
T7320 29899-29909 NNS denotes mechanisms
T7321 30013-30019 VBP denotes remain
T7322 29910-29917 WRB denotes whereby
T7323 29970-29974 VBP denotes lead
T7324 29918-29927 NNS denotes mutations
T7325 29928-29930 IN denotes in
T7326 29931-29934 NN denotes rod
T7327 29935-29943 JJ denotes specific
T7328 29934-29935 HYPH denotes -
T7329 29944-29949 NNS denotes genes
T7330 29949-29951 , denotes ,
T7331 29951-29955 JJ denotes such
T7332 29956-29958 IN denotes as
T7333 29959-29968 NN denotes rhodopsin
T7334 29968-29970 , denotes ,
T7335 29975-29985 RB denotes eventually
T7336 29986-29988 IN denotes to
T7337 29989-29993 NN denotes cone
T7338 29994-30006 NN denotes degeneration
T7339 30007-30009 IN denotes in
T7340 30010-30012 NN denotes RP
T7341 30020-30027 JJ denotes obscure
T7342 30027-30028 . denotes .
T7343 30028-30167 sentence denotes Mutations in Crx were the first, and still one of a very few examples of a transcription factor mutation leading to photoreceptor disease.
T7344 30029-30038 NNS denotes Mutations
T7345 30046-30050 VBD denotes were
T7346 30039-30041 IN denotes in
T7347 30042-30045 NN denotes Crx
T7348 30051-30054 DT denotes the
T7349 30055-30060 JJ denotes first
T7350 30060-30062 , denotes ,
T7351 30062-30065 CC denotes and
T7352 30066-30071 RB denotes still
T7353 30072-30075 CD denotes one
T7354 30090-30098 NNS denotes examples
T7355 30076-30078 IN denotes of
T7356 30079-30080 DT denotes a
T7357 30086-30089 JJ denotes few
T7358 30081-30085 RB denotes very
T7359 30099-30101 IN denotes of
T7360 30102-30103 DT denotes a
T7361 30125-30133 NN denotes mutation
T7362 30104-30117 NN denotes transcription
T7363 30118-30124 NN denotes factor
T7364 30134-30141 VBG denotes leading
T7365 30142-30144 IN denotes to
T7366 30145-30158 NN denotes photoreceptor
T7367 30159-30166 NN denotes disease
T7368 30166-30167 . denotes .
T7369 30167-30314 sentence denotes LCA is a disease in which there is little or no photoreceptor function in infancy; thereby, likely developmental in etiology ([17,56] for review).
T7370 30168-30171 NN denotes LCA
T7371 30172-30174 VBZ denotes is
T7372 30175-30176 DT denotes a
T7373 30177-30184 NN denotes disease
T7374 30185-30187 IN denotes in
T7375 30200-30202 VBZ denotes is
T7376 30188-30193 WDT denotes which
T7377 30194-30199 EX denotes there
T7378 30203-30209 JJ denotes little
T7379 30230-30238 NN denotes function
T7380 30210-30212 CC denotes or
T7381 30213-30215 DT denotes no
T7382 30216-30229 NN denotes photoreceptor
T7383 30239-30241 IN denotes in
T7384 30242-30249 NN denotes infancy
T7385 30249-30250 : denotes ;
T7386 30251-30258 RB denotes thereby
T7387 30267-30280 JJ denotes developmental
T7388 30258-30260 , denotes ,
T7389 30260-30266 RB denotes likely
T7390 30281-30283 IN denotes in
T7391 30284-30292 NN denotes etiology
T7392 30293-30294 -LRB- denotes (
T7393 30298-30300 CD denotes 56
T7394 30294-30295 -LRB- denotes [
T7395 30295-30297 CD denotes 17
T7396 30297-30298 , denotes ,
T7397 30300-30301 -RRB- denotes ]
T7398 30302-30305 IN denotes for
T7399 30306-30312 NN denotes review
T7400 30312-30313 -RRB- denotes )
T7401 30313-30314 . denotes .
T7402 30314-30477 sentence denotes The Crx-/- mouse may be an excellent model for studying the pathology of this disorder, particularly the subtype of the disorder where Crx mutations are involved.
T7403 30315-30318 DT denotes The
T7404 30326-30331 NN denotes mouse
T7405 30319-30322 NN denotes Crx
T7406 30322-30323 SYM denotes -
T7407 30323-30324 HYPH denotes /
T7408 30324-30325 SYM denotes -
T7409 30336-30338 VB denotes be
T7410 30332-30335 MD denotes may
T7411 30339-30341 DT denotes an
T7412 30352-30357 NN denotes model
T7413 30342-30351 JJ denotes excellent
T7414 30358-30361 IN denotes for
T7415 30362-30370 VBG denotes studying
T7416 30371-30374 DT denotes the
T7417 30375-30384 NN denotes pathology
T7418 30385-30387 IN denotes of
T7419 30388-30392 DT denotes this
T7420 30393-30401 NN denotes disorder
T7421 30401-30403 , denotes ,
T7422 30403-30415 RB denotes particularly
T7423 30420-30427 NN denotes subtype
T7424 30416-30419 DT denotes the
T7425 30428-30430 IN denotes of
T7426 30431-30434 DT denotes the
T7427 30435-30443 NN denotes disorder
T7428 30444-30449 WRB denotes where
T7429 30468-30476 VBN denotes involved
T7430 30450-30453 NN denotes Crx
T7431 30454-30463 NNS denotes mutations
T7432 30464-30467 VBP denotes are
T7433 30476-30477 . denotes .
T7434 30477-30644 sentence denotes The vast majority of histopathological studies of LCA in human tissue have been derived from adult patients with LCA where secondary changes are likely to be present.
T7435 30478-30481 DT denotes The
T7436 30487-30495 NN denotes majority
T7437 30482-30486 JJ denotes vast
T7438 30558-30565 VBN denotes derived
T7439 30496-30498 IN denotes of
T7440 30499-30516 JJ denotes histopathological
T7441 30517-30524 NNS denotes studies
T7442 30525-30527 IN denotes of
T7443 30528-30531 NN denotes LCA
T7444 30532-30534 IN denotes in
T7445 30535-30540 JJ denotes human
T7446 30541-30547 NN denotes tissue
T7447 30548-30552 VBP denotes have
T7448 30553-30557 VBN denotes been
T7449 30566-30570 IN denotes from
T7450 30571-30576 JJ denotes adult
T7451 30577-30585 NNS denotes patients
T7452 30586-30590 IN denotes with
T7453 30591-30594 NN denotes LCA
T7454 30595-30600 WRB denotes where
T7455 30619-30622 VBP denotes are
T7456 30601-30610 JJ denotes secondary
T7457 30611-30618 NNS denotes changes
T7458 30623-30629 JJ denotes likely
T7459 30630-30632 TO denotes to
T7460 30633-30635 VB denotes be
T7461 30636-30643 JJ denotes present
T7462 30643-30644 . denotes .
T7463 30644-30788 sentence denotes Indeed in animal models of LCA, secondary reactive and/or degenerative changes occur early after the abnormal formation of retinal tissue [57].
T7464 30645-30651 RB denotes Indeed
T7465 30724-30729 VBP denotes occur
T7466 30652-30654 IN denotes in
T7467 30655-30661 NN denotes animal
T7468 30662-30668 NNS denotes models
T7469 30669-30671 IN denotes of
T7470 30672-30675 NN denotes LCA
T7471 30675-30677 , denotes ,
T7472 30677-30686 JJ denotes secondary
T7473 30716-30723 NNS denotes changes
T7474 30687-30695 JJ denotes reactive
T7475 30696-30699 CC denotes and
T7476 30699-30700 HYPH denotes /
T7477 30700-30702 CC denotes or
T7478 30703-30715 JJ denotes degenerative
T7479 30730-30735 RB denotes early
T7480 30736-30741 IN denotes after
T7481 30742-30745 DT denotes the
T7482 30755-30764 NN denotes formation
T7483 30746-30754 JJ denotes abnormal
T7484 30765-30767 IN denotes of
T7485 30768-30775 JJ denotes retinal
T7486 30776-30782 NN denotes tissue
T7487 30783-30784 -LRB- denotes [
T7488 30784-30786 CD denotes 57
T7489 30786-30787 -RRB- denotes ]
T7490 30787-30788 . denotes .
T7491 30788-30949 sentence denotes The only study in human tissue derived from a human 33-week retina with proposed RPE65 mutations was reported to have abnormal retinae at this early stage [24].
T7492 30789-30792 DT denotes The
T7493 30798-30803 NN denotes study
T7494 30793-30797 JJ denotes only
T7495 30890-30898 VBN denotes reported
T7496 30804-30806 IN denotes in
T7497 30807-30812 JJ denotes human
T7498 30813-30819 NN denotes tissue
T7499 30820-30827 VBN denotes derived
T7500 30828-30832 IN denotes from
T7501 30833-30834 DT denotes a
T7502 30849-30855 NN denotes retina
T7503 30835-30840 JJ denotes human
T7504 30841-30843 CD denotes 33
T7505 30844-30848 NN denotes week
T7506 30843-30844 HYPH denotes -
T7507 30856-30860 IN denotes with
T7508 30861-30869 VBN denotes proposed
T7509 30876-30885 NNS denotes mutations
T7510 30870-30875 NN denotes RPE65
T7511 30886-30889 VBD denotes was
T7512 30899-30901 TO denotes to
T7513 30902-30906 VB denotes have
T7514 30907-30915 JJ denotes abnormal
T7515 30916-30923 NNS denotes retinae
T7516 30924-30926 IN denotes at
T7517 30927-30931 DT denotes this
T7518 30938-30943 NN denotes stage
T7519 30932-30937 JJ denotes early
T7520 30944-30945 -LRB- denotes [
T7521 30945-30947 CD denotes 24
T7522 30947-30948 -RRB- denotes ]
T7523 30948-30949 . denotes .
T7524 30949-31028 sentence denotes These authors report cell loss, including thinning of the photoreceptor layer.
T7525 30950-30955 DT denotes These
T7526 30956-30963 NNS denotes authors
T7527 30964-30970 VBP denotes report
T7528 30971-30975 NN denotes cell
T7529 30976-30980 NN denotes loss
T7530 30980-30982 , denotes ,
T7531 30982-30991 VBG denotes including
T7532 30992-31000 NN denotes thinning
T7533 31001-31003 IN denotes of
T7534 31004-31007 DT denotes the
T7535 31022-31027 NN denotes layer
T7536 31008-31021 NN denotes photoreceptor
T7537 31027-31028 . denotes .
T7538 31028-31246 sentence denotes In addition, they claim in the text to have seen aberrant synaptic and inner retinal organization, although their examination of photoreceptor synapses unfortunately are not presented in the data section of the paper.
T7539 31029-31031 IN denotes In
T7540 31047-31052 VBP denotes claim
T7541 31032-31040 NN denotes addition
T7542 31040-31042 , denotes ,
T7543 31042-31046 PRP denotes they
T7544 31053-31055 IN denotes in
T7545 31056-31059 DT denotes the
T7546 31060-31064 NN denotes text
T7547 31065-31067 TO denotes to
T7548 31073-31077 VBN denotes seen
T7549 31068-31072 VB denotes have
T7550 31078-31086 JJ denotes aberrant
T7551 31114-31126 NN denotes organization
T7552 31087-31095 JJ denotes synaptic
T7553 31096-31099 CC denotes and
T7554 31100-31105 JJ denotes inner
T7555 31106-31113 JJ denotes retinal
T7556 31126-31128 , denotes ,
T7557 31128-31136 IN denotes although
T7558 31203-31212 VBN denotes presented
T7559 31137-31142 PRP$ denotes their
T7560 31143-31154 NN denotes examination
T7561 31155-31157 IN denotes of
T7562 31158-31171 NN denotes photoreceptor
T7563 31172-31180 NNS denotes synapses
T7564 31181-31194 RB denotes unfortunately
T7565 31195-31198 VBP denotes are
T7566 31199-31202 RB denotes not
T7567 31213-31215 IN denotes in
T7568 31216-31219 DT denotes the
T7569 31225-31232 NN denotes section
T7570 31220-31224 NNS denotes data
T7571 31233-31235 IN denotes of
T7572 31236-31239 DT denotes the
T7573 31240-31245 NN denotes paper
T7574 31245-31246 . denotes .
T7575 31246-31373 sentence denotes Given the scarcity of available human tissue, the characterization of the primary pathology of LCA will require animal models.
T7576 31247-31252 VBN denotes Given
T7577 31351-31358 VB denotes require
T7578 31253-31256 DT denotes the
T7579 31257-31265 NN denotes scarcity
T7580 31266-31268 IN denotes of
T7581 31269-31278 JJ denotes available
T7582 31285-31291 NN denotes tissue
T7583 31279-31284 JJ denotes human
T7584 31291-31293 , denotes ,
T7585 31293-31296 DT denotes the
T7586 31297-31313 NN denotes characterization
T7587 31314-31316 IN denotes of
T7588 31317-31320 DT denotes the
T7589 31329-31338 NN denotes pathology
T7590 31321-31328 JJ denotes primary
T7591 31339-31341 IN denotes of
T7592 31342-31345 NN denotes LCA
T7593 31346-31350 MD denotes will
T7594 31359-31365 NN denotes animal
T7595 31366-31372 NNS denotes models
T7596 31372-31373 . denotes .
T7597 31373-31548 sentence denotes In the current study, we present data that argue that, in addition to outer segment morphogenesis, synaptogenesis may also be critically impaired in at least a subset of LCA.
T7598 31374-31376 IN denotes In
T7599 31399-31406 VBP denotes present
T7600 31377-31380 DT denotes the
T7601 31389-31394 NN denotes study
T7602 31381-31388 JJ denotes current
T7603 31394-31396 , denotes ,
T7604 31396-31398 PRP denotes we
T7605 31407-31411 NNS denotes data
T7606 31412-31416 WDT denotes that
T7607 31417-31422 VBP denotes argue
T7608 31423-31427 IN denotes that
T7609 31497-31499 VB denotes be
T7610 31427-31429 , denotes ,
T7611 31429-31431 IN denotes in
T7612 31432-31440 NN denotes addition
T7613 31441-31443 IN denotes to
T7614 31444-31449 JJ denotes outer
T7615 31450-31457 NN denotes segment
T7616 31458-31471 NN denotes morphogenesis
T7617 31471-31473 , denotes ,
T7618 31473-31487 NN denotes synaptogenesis
T7619 31488-31491 MD denotes may
T7620 31492-31496 RB denotes also
T7621 31500-31510 RB denotes critically
T7622 31511-31519 JJ denotes impaired
T7623 31520-31522 IN denotes in
T7624 31523-31525 RB denotes at
T7625 31532-31533 DT denotes a
T7626 31526-31531 RBS denotes least
T7627 31534-31540 NN denotes subset
T7628 31541-31543 IN denotes of
T7629 31544-31547 NN denotes LCA
T7630 31547-31548 . denotes .
T7656 31559-31563 NNS denotes Mice
T7657 31563-31618 sentence denotes Crx-/- mice were generated as reported elsewhere [34].
T7658 31564-31567 NN denotes Crx
T7659 31571-31575 NNS denotes mice
T7660 31567-31568 SYM denotes -
T7661 31568-31569 HYPH denotes /
T7662 31569-31570 SYM denotes -
T7663 31581-31590 VBN denotes generated
T7664 31576-31580 VBD denotes were
T7665 31591-31593 IN denotes as
T7666 31594-31602 VBN denotes reported
T7667 31603-31612 RB denotes elsewhere
T7668 31613-31614 -LRB- denotes [
T7669 31614-31616 CD denotes 34
T7670 31616-31617 -RRB- denotes ]
T7671 31617-31618 . denotes .
T7672 31618-31700 sentence denotes Rhodosin-null mice [29] were obtained from Paul Sieving (University of Michigan).
T7673 31619-31627 NN denotes Rhodosin
T7674 31628-31632 JJ denotes null
T7675 31627-31628 HYPH denotes -
T7676 31633-31637 NNS denotes mice
T7677 31648-31656 VBN denotes obtained
T7678 31638-31639 -LRB- denotes [
T7679 31639-31641 CD denotes 29
T7680 31641-31642 -RRB- denotes ]
T7681 31643-31647 VBD denotes were
T7682 31657-31661 IN denotes from
T7683 31662-31666 NNP denotes Paul
T7684 31667-31674 NNP denotes Sieving
T7685 31675-31676 -LRB- denotes (
T7686 31676-31686 NNP denotes University
T7687 31687-31689 IN denotes of
T7688 31690-31698 NNP denotes Michigan
T7689 31698-31699 -RRB- denotes )
T7690 31699-31700 . denotes .
T7691 31700-31748 sentence denotes Rds mice were acquired from Jackson Laboratory.
T7692 31701-31704 NN denotes Rds
T7693 31705-31709 NNS denotes mice
T7694 31715-31723 VBN denotes acquired
T7695 31710-31714 VBD denotes were
T7696 31724-31728 IN denotes from
T7697 31729-31736 NNP denotes Jackson
T7698 31737-31747 NNP denotes Laboratory
T7699 31747-31748 . denotes .
T7779 31750-31762 NN denotes Transmission
T7780 31772-31782 NN denotes microscopy
T7781 31763-31771 NN denotes electron
T7782 31782-31904 sentence denotes Littermate Crx-/- and wildtype pups were perfused in 1% formaldehyde and 0.5% glutaraldehyde at various postnatal stages.
T7783 31783-31793 NN denotes Littermate
T7784 31814-31818 NNS denotes pups
T7785 31794-31797 NN denotes Crx
T7786 31797-31798 SYM denotes -
T7787 31798-31799 HYPH denotes /
T7788 31799-31800 SYM denotes -
T7789 31801-31804 CC denotes and
T7790 31805-31813 JJ denotes wildtype
T7791 31824-31832 VBN denotes perfused
T7792 31819-31823 VBD denotes were
T7793 31833-31835 IN denotes in
T7794 31836-31837 CD denotes 1
T7795 31837-31838 NN denotes %
T7796 31839-31851 NN denotes formaldehyde
T7797 31852-31855 CC denotes and
T7798 31856-31859 CD denotes 0.5
T7799 31859-31860 NN denotes %
T7800 31861-31875 NN denotes glutaraldehyde
T7801 31876-31878 IN denotes at
T7802 31879-31886 JJ denotes various
T7803 31897-31903 NNS denotes stages
T7804 31887-31896 JJ denotes postnatal
T7805 31903-31904 . denotes .
T7806 31904-31973 sentence denotes The eyes were then enucleated, and the cornea and lens were removed.
T7807 31905-31908 DT denotes The
T7808 31909-31913 NNS denotes eyes
T7809 31924-31934 VBN denotes enucleated
T7810 31914-31918 VBD denotes were
T7811 31919-31923 RB denotes then
T7812 31934-31936 , denotes ,
T7813 31936-31939 CC denotes and
T7814 31940-31943 DT denotes the
T7815 31944-31950 NN denotes cornea
T7816 31965-31972 VBN denotes removed
T7817 31951-31954 CC denotes and
T7818 31955-31959 NN denotes lens
T7819 31960-31964 VBD denotes were
T7820 31972-31973 . denotes .
T7821 31973-32077 sentence denotes The eye cup was immersed in fixative (1% formaldehyde and 2.5% glutaraldehyde) for 3 to 4 hours at 4°C.
T7822 31974-31977 DT denotes The
T7823 31982-31985 NN denotes cup
T7824 31978-31981 NN denotes eye
T7825 31990-31998 VBN denotes immersed
T7826 31986-31989 VBD denotes was
T7827 31999-32001 IN denotes in
T7828 32002-32010 NN denotes fixative
T7829 32011-32012 -LRB- denotes (
T7830 32012-32013 CD denotes 1
T7831 32013-32014 NN denotes %
T7832 32015-32027 NN denotes formaldehyde
T7833 32028-32031 CC denotes and
T7834 32032-32035 CD denotes 2.5
T7835 32035-32036 NN denotes %
T7836 32037-32051 NN denotes glutaraldehyde
T7837 32051-32052 -RRB- denotes )
T7838 32053-32056 IN denotes for
T7839 32057-32058 CD denotes 3
T7840 32062-32063 CD denotes 4
T7841 32059-32061 IN denotes to
T7842 32064-32069 NNS denotes hours
T7843 32070-32072 IN denotes at
T7844 32073-32074 CD denotes 4
T7845 32074-32076 NN denotes °C
T7846 32076-32077 . denotes .
T7847 32077-32235 sentence denotes The sclera was then partially removed and the retinas were sliced into small pieces and fixed (1% paraformaldehyde and 2.5% glutaraldehyde) overnight at 4°C.
T7848 32078-32081 DT denotes The
T7849 32082-32088 NN denotes sclera
T7850 32108-32115 VBN denotes removed
T7851 32089-32092 VBD denotes was
T7852 32093-32097 RB denotes then
T7853 32098-32107 RB denotes partially
T7854 32116-32119 CC denotes and
T7855 32120-32123 DT denotes the
T7856 32124-32131 NNS denotes retinas
T7857 32137-32143 VBN denotes sliced
T7858 32132-32136 VBD denotes were
T7859 32144-32148 IN denotes into
T7860 32149-32154 JJ denotes small
T7861 32155-32161 NNS denotes pieces
T7862 32162-32165 CC denotes and
T7863 32166-32171 VBN denotes fixed
T7864 32172-32173 -LRB- denotes (
T7865 32176-32192 NN denotes paraformaldehyde
T7866 32173-32174 CD denotes 1
T7867 32174-32175 NN denotes %
T7868 32193-32196 CC denotes and
T7869 32197-32200 CD denotes 2.5
T7870 32200-32201 NN denotes %
T7871 32202-32216 NN denotes glutaraldehyde
T7872 32216-32217 -RRB- denotes )
T7873 32218-32227 RB denotes overnight
T7874 32228-32230 IN denotes at
T7875 32231-32232 CD denotes 4
T7876 32232-32234 NN denotes °C
T7877 32234-32235 . denotes .
T7878 32235-32349 sentence denotes These procedures were found optimal for maintaining the structural integrity of the photoreceptor outer segments.
T7879 32236-32241 DT denotes These
T7880 32242-32252 NNS denotes procedures
T7881 32258-32263 VBN denotes found
T7882 32253-32257 VBD denotes were
T7883 32264-32271 JJ denotes optimal
T7884 32272-32275 IN denotes for
T7885 32276-32287 VBG denotes maintaining
T7886 32288-32291 DT denotes the
T7887 32303-32312 NN denotes integrity
T7888 32292-32302 JJ denotes structural
T7889 32313-32315 IN denotes of
T7890 32316-32319 DT denotes the
T7891 32340-32348 NNS denotes segments
T7892 32320-32333 NN denotes photoreceptor
T7893 32334-32339 JJ denotes outer
T7894 32348-32349 . denotes .
T7895 32349-32424 sentence denotes After fixing, the tissue was washed 2X in PBS for thirty minutes per wash.
T7896 32350-32355 IN denotes After
T7897 32379-32385 VBN denotes washed
T7898 32356-32362 NN denotes fixing
T7899 32362-32364 , denotes ,
T7900 32364-32367 DT denotes the
T7901 32368-32374 NN denotes tissue
T7902 32375-32378 VBD denotes was
T7903 32386-32387 CD denotes 2
T7904 32387-32388 SYM denotes X
T7905 32389-32391 IN denotes in
T7906 32392-32395 NN denotes PBS
T7907 32396-32399 IN denotes for
T7908 32400-32406 CD denotes thirty
T7909 32407-32414 NNS denotes minutes
T7910 32415-32418 IN denotes per
T7911 32419-32423 NN denotes wash
T7912 32423-32424 . denotes .
T7913 32424-32535 sentence denotes The tissue was then postfixed in a 1% osmium tetroxide/1.5% potassium ferrocyanide mixture for 2 hours at 4°C.
T7914 32425-32428 DT denotes The
T7915 32429-32435 NN denotes tissue
T7916 32445-32454 VBN denotes postfixed
T7917 32436-32439 VBD denotes was
T7918 32440-32444 RB denotes then
T7919 32455-32457 IN denotes in
T7920 32458-32459 DT denotes a
T7921 32508-32515 NN denotes mixture
T7922 32460-32461 CD denotes 1
T7923 32461-32462 NN denotes %
T7924 32470-32479 NN denotes tetroxide
T7925 32463-32469 NN denotes osmium
T7926 32479-32480 HYPH denotes /
T7927 32480-32483 CD denotes 1.5
T7928 32483-32484 NN denotes %
T7929 32495-32507 NN denotes ferrocyanide
T7930 32485-32494 NN denotes potassium
T7931 32516-32519 IN denotes for
T7932 32520-32521 CD denotes 2
T7933 32522-32527 NNS denotes hours
T7934 32528-32530 IN denotes at
T7935 32531-32532 CD denotes 4
T7936 32532-32534 NN denotes °C
T7937 32534-32535 . denotes .
T7938 32535-32730 sentence denotes Staining was carried out for 30 minutes in 1% uranyl acetate in maleate buffer (pH = 6.0) at room temperature followed by 1% tannic acid in 0.1 M cacodylate buffer (pH = 7.4) for thirty minutes.
T7939 32536-32544 NN denotes Staining
T7940 32549-32556 VBN denotes carried
T7941 32545-32548 VBD denotes was
T7942 32557-32560 RP denotes out
T7943 32561-32564 IN denotes for
T7944 32565-32567 CD denotes 30
T7945 32568-32575 NNS denotes minutes
T7946 32576-32578 IN denotes in
T7947 32579-32580 CD denotes 1
T7948 32580-32581 NN denotes %
T7949 32589-32596 NN denotes acetate
T7950 32582-32588 NN denotes uranyl
T7951 32597-32599 IN denotes in
T7952 32600-32607 NN denotes maleate
T7953 32608-32614 NN denotes buffer
T7954 32615-32616 -LRB- denotes (
T7955 32621-32624 CD denotes 6.0
T7956 32616-32618 NN denotes pH
T7957 32619-32620 SYM denotes =
T7958 32624-32625 -RRB- denotes )
T7959 32626-32628 IN denotes at
T7960 32629-32633 NN denotes room
T7961 32634-32645 NN denotes temperature
T7962 32646-32654 VBN denotes followed
T7963 32655-32657 IN denotes by
T7964 32658-32659 CD denotes 1
T7965 32659-32660 NN denotes %
T7966 32668-32672 NN denotes acid
T7967 32661-32667 JJ denotes tannic
T7968 32673-32675 IN denotes in
T7969 32676-32679 CD denotes 0.1
T7970 32680-32681 NN denotes M
T7971 32693-32699 NN denotes buffer
T7972 32682-32692 NN denotes cacodylate
T7973 32700-32701 -LRB- denotes (
T7974 32706-32709 CD denotes 7.4
T7975 32701-32703 NN denotes pH
T7976 32704-32705 SYM denotes =
T7977 32709-32710 -RRB- denotes )
T7978 32711-32714 IN denotes for
T7979 32715-32721 CD denotes thirty
T7980 32722-32729 NNS denotes minutes
T7981 32729-32730 . denotes .
T7982 32730-32796 sentence denotes The specimens were then dehydrated and embedded in Epon/Araldite.
T7983 32731-32734 DT denotes The
T7984 32735-32744 NNS denotes specimens
T7985 32755-32765 VBN denotes dehydrated
T7986 32745-32749 VBD denotes were
T7987 32750-32754 RB denotes then
T7988 32766-32769 CC denotes and
T7989 32770-32778 VBN denotes embedded
T7990 32779-32781 IN denotes in
T7991 32782-32786 NN denotes Epon
T7992 32787-32795 NN denotes Araldite
T7993 32786-32787 HYPH denotes /
T7994 32795-32796 . denotes .
T7995 32796-32916 sentence denotes Thin sections were stained with uranyl acetate and lead citrate, and examined in a Jeol JEM-1200EX electron microscope.
T7996 32797-32801 JJ denotes Thin
T7997 32802-32810 NNS denotes sections
T7998 32816-32823 VBN denotes stained
T7999 32811-32815 VBD denotes were
T8000 32824-32828 IN denotes with
T8001 32829-32835 NN denotes uranyl
T8002 32836-32843 NN denotes acetate
T8003 32844-32847 CC denotes and
T8004 32848-32852 NN denotes lead
T8005 32853-32860 NN denotes citrate
T8006 32860-32862 , denotes ,
T8007 32862-32865 CC denotes and
T8008 32866-32874 VBN denotes examined
T8009 32875-32877 IN denotes in
T8010 32878-32879 DT denotes a
T8011 32905-32915 NN denotes microscope
T8012 32880-32884 NNP denotes Jeol
T8013 32889-32895 NNP denotes 1200EX
T8014 32885-32888 NNP denotes JEM
T8015 32888-32889 HYPH denotes -
T8016 32896-32904 NN denotes electron
T8017 32915-32916 . denotes .
T8072 32918-32926 VBG denotes Scanning
T8073 32936-32946 NN denotes microscopy
T8074 32927-32935 NN denotes electron
T8075 32946-33092 sentence denotes Specimens used for SEM required removal of the retinal pigment epithelium (PE), enabling visualization of the outer surface of the neural retina.
T8076 32947-32956 NNS denotes Specimens
T8077 32970-32978 VBD denotes required
T8078 32957-32961 VBN denotes used
T8079 32962-32965 IN denotes for
T8080 32966-32969 NN denotes SEM
T8081 32979-32986 NN denotes removal
T8082 32987-32989 IN denotes of
T8083 32990-32993 DT denotes the
T8084 33010-33020 NN denotes epithelium
T8085 32994-33001 JJ denotes retinal
T8086 33002-33009 NN denotes pigment
T8087 33021-33022 -LRB- denotes (
T8088 33022-33024 NN denotes PE
T8089 33024-33025 -RRB- denotes )
T8090 33025-33027 , denotes ,
T8091 33027-33035 VBG denotes enabling
T8092 33036-33049 NN denotes visualization
T8093 33050-33052 IN denotes of
T8094 33053-33056 DT denotes the
T8095 33063-33070 NN denotes surface
T8096 33057-33062 JJ denotes outer
T8097 33071-33073 IN denotes of
T8098 33074-33077 DT denotes the
T8099 33085-33091 NN denotes retina
T8100 33078-33084 JJ denotes neural
T8101 33091-33092 . denotes .
T8102 33092-33273 sentence denotes Retinae from Crx-/-, rhodopsin-/-, RDS, or wildtype eyes were dissected free from PE in a dispase solution and fixed in 1.25% glutaraldehyde and 1.0% formaldehyde overnight at 4°C.
T8103 33093-33100 NNS denotes Retinae
T8104 33155-33164 VBN denotes dissected
T8105 33101-33105 IN denotes from
T8106 33106-33109 NN denotes Crx
T8107 33145-33149 NNS denotes eyes
T8108 33109-33110 SYM denotes -
T8109 33110-33111 HYPH denotes /
T8110 33111-33112 SYM denotes -
T8111 33112-33114 , denotes ,
T8112 33114-33123 NN denotes rhodopsin
T8113 33123-33124 SYM denotes -
T8114 33124-33125 HYPH denotes /
T8115 33125-33126 SYM denotes -
T8116 33126-33128 , denotes ,
T8117 33128-33131 NN denotes RDS
T8118 33131-33133 , denotes ,
T8119 33133-33135 CC denotes or
T8120 33136-33144 NN denotes wildtype
T8121 33150-33154 VBD denotes were
T8122 33165-33169 JJ denotes free
T8123 33170-33174 IN denotes from
T8124 33175-33177 NN denotes PE
T8125 33178-33180 IN denotes in
T8126 33181-33182 DT denotes a
T8127 33191-33199 NN denotes solution
T8128 33183-33190 NN denotes dispase
T8129 33200-33203 CC denotes and
T8130 33204-33209 VBN denotes fixed
T8131 33210-33212 IN denotes in
T8132 33213-33217 CD denotes 1.25
T8133 33217-33218 NN denotes %
T8134 33219-33233 NN denotes glutaraldehyde
T8135 33234-33237 CC denotes and
T8136 33238-33241 CD denotes 1.0
T8137 33241-33242 NN denotes %
T8138 33243-33255 NN denotes formaldehyde
T8139 33256-33265 RB denotes overnight
T8140 33266-33268 IN denotes at
T8141 33269-33270 CD denotes 4
T8142 33270-33272 NN denotes °C
T8143 33272-33273 . denotes .
T8144 33273-33367 sentence denotes Tissue was then washed 5X in cacodylate buffer and dehydrated in ascending grades of ethanol.
T8145 33274-33280 NN denotes Tissue
T8146 33290-33296 VBN denotes washed
T8147 33281-33284 VBD denotes was
T8148 33285-33289 RB denotes then
T8149 33297-33298 CD denotes 5
T8150 33298-33299 SYM denotes X
T8151 33300-33302 IN denotes in
T8152 33303-33313 NN denotes cacodylate
T8153 33314-33320 NN denotes buffer
T8154 33321-33324 CC denotes and
T8155 33325-33335 VBN denotes dehydrated
T8156 33336-33338 IN denotes in
T8157 33339-33348 VBG denotes ascending
T8158 33349-33355 NNS denotes grades
T8159 33356-33358 IN denotes of
T8160 33359-33366 NN denotes ethanol
T8161 33366-33367 . denotes .
T8162 33367-33433 sentence denotes Tissues were subsequently critical point dried in carbon dioxide.
T8163 33368-33375 NNS denotes Tissues
T8164 33409-33414 VBN denotes dried
T8165 33376-33380 VBD denotes were
T8166 33381-33393 RB denotes subsequently
T8167 33394-33402 JJ denotes critical
T8168 33403-33408 NN denotes point
T8169 33415-33417 IN denotes in
T8170 33418-33424 NN denotes carbon
T8171 33425-33432 NN denotes dioxide
T8172 33432-33433 . denotes .
T8173 33433-33531 sentence denotes All specimens were mounted and coated with sublimated gold-palladium by the sputtering technique.
T8174 33434-33437 DT denotes All
T8175 33438-33447 NNS denotes specimens
T8176 33453-33460 VBN denotes mounted
T8177 33448-33452 VBD denotes were
T8178 33461-33464 CC denotes and
T8179 33465-33471 VBN denotes coated
T8180 33472-33476 IN denotes with
T8181 33477-33487 VBN denotes sublimated
T8182 33493-33502 NN denotes palladium
T8183 33488-33492 NN denotes gold
T8184 33492-33493 HYPH denotes -
T8185 33503-33505 IN denotes by
T8186 33506-33509 DT denotes the
T8187 33521-33530 NN denotes technique
T8188 33510-33520 NN denotes sputtering
T8189 33530-33531 . denotes .
T8190 33531-33608 sentence denotes Micrographs were obtained with a Jeol JSM-35CF scanning electron microscope.
T8191 33532-33543 NNS denotes Micrographs
T8192 33549-33557 VBN denotes obtained
T8193 33544-33548 VBD denotes were
T8194 33558-33562 IN denotes with
T8195 33563-33564 DT denotes a
T8196 33597-33607 NN denotes microscope
T8197 33565-33569 NNP denotes Jeol
T8198 33574-33578 NNP denotes 35CF
T8199 33570-33573 NNP denotes JSM
T8200 33573-33574 HYPH denotes -
T8201 33579-33587 VBG denotes scanning
T8202 33588-33596 NN denotes electron
T8203 33607-33608 . denotes .
T8250 7502-7514 NN denotes Transmission
T8251 7524-7534 NN denotes microscopy
T8252 7515-7523 NN denotes electron
T8253 7535-7537 IN denotes of
T8254 7538-7541 DT denotes the
T8255 7548-7554 NN denotes retina
T8256 7542-7547 JJ denotes outer
T8257 7555-7557 IN denotes at
T8258 7558-7561 NN denotes P21
T8259 7562-7564 IN denotes in
T8260 7565-7566 -LRB- denotes (
T8261 7566-7567 LS denotes A
T8262 7569-7572 NN denotes Crx
T8263 7567-7568 -RRB- denotes )
T8264 7591-7598 NNS denotes retinas
T8265 7572-7573 SYM denotes +
T8266 7573-7574 HYPH denotes /
T8267 7574-7575 SYM denotes +
T8268 7576-7579 CC denotes and
T8269 7580-7581 -LRB- denotes (
T8270 7581-7582 LS denotes B
T8271 7584-7587 NN denotes Crx
T8272 7582-7583 -RRB- denotes )
T8273 7587-7588 SYM denotes -
T8274 7588-7589 HYPH denotes /
T8275 7589-7590 SYM denotes -
T8276 7598-7599 . denotes .
T8277 7599-7625 sentence denotes pe, pigmented epithelium.
T8278 7600-7602 NN denotes pe
T8279 7602-7604 , denotes ,
T8280 7604-7613 JJ denotes pigmented
T8281 7614-7624 NN denotes epithelium
T8282 7624-7625 . denotes .
T8283 7625-7645 sentence denotes os, outer segments.
T8284 7626-7628 NN denotes os
T8285 7628-7630 , denotes ,
T8286 7630-7635 JJ denotes outer
T8287 7636-7644 NNS denotes segments
T8288 7644-7645 . denotes .
T8289 7645-7665 sentence denotes is, inner segments.
T8290 7646-7648 NN denotes is
T8291 7648-7650 , denotes ,
T8292 7650-7655 JJ denotes inner
T8293 7656-7664 NNS denotes segments
T8294 7664-7665 . denotes .
T8295 7665-7717 sentence denotes onl, outer nuclear layer with photoreceptor nuclei.
T8296 7666-7669 NN denotes onl
T8297 7669-7671 , denotes ,
T8298 7671-7676 JJ denotes outer
T8299 7685-7690 NN denotes layer
T8300 7677-7684 JJ denotes nuclear
T8301 7691-7695 IN denotes with
T8302 7696-7709 NN denotes photoreceptor
T8303 7710-7716 NNS denotes nuclei
T8304 7716-7717 . denotes .
T8305 7717-7747 sentence denotes Scale bar = 5 μm for A and B.
T8306 7718-7723 NN denotes Scale
T8307 7724-7727 NN denotes bar
T8308 7732-7734 NN denotes μm
T8309 7728-7729 SYM denotes =
T8310 7730-7731 CD denotes 5
T8311 7735-7738 IN denotes for
T8312 7739-7740 NN denotes A
T8313 7741-7744 CC denotes and
T8314 7745-7746 NN denotes B
T8315 7746-7747 . denotes .
T8372 7758-7770 NN denotes Transmission
T8373 7780-7790 NN denotes micrograph
T8374 7771-7779 NN denotes electron
T8375 7791-7793 IN denotes of
T8376 7794-7797 DT denotes the
T8377 7812-7817 NN denotes layer
T8378 7798-7803 JJ denotes outer
T8379 7804-7811 NN denotes segment
T8380 7818-7820 IN denotes of
T8381 7821-7824 NN denotes Crx
T8382 7828-7834 NN denotes retina
T8383 7824-7825 SYM denotes -
T8384 7825-7826 HYPH denotes /
T8385 7826-7827 SYM denotes -
T8386 7835-7837 IN denotes at
T8387 7838-7841 NN denotes P21
T8388 7841-7842 . denotes .
T8389 7842-7961 sentence denotes Inner segments of Crx-/- photoreceptors exhibit numerous mitochondria (m indicated by arrow) as in Crx+/+ (Figure 1A).
T8390 7843-7848 JJ denotes Inner
T8391 7849-7857 NNS denotes segments
T8392 7883-7890 VBP denotes exhibit
T8393 7858-7860 IN denotes of
T8394 7861-7864 NN denotes Crx
T8395 7868-7882 NNS denotes photoreceptors
T8396 7864-7865 SYM denotes -
T8397 7865-7866 HYPH denotes /
T8398 7866-7867 SYM denotes -
T8399 7891-7899 JJ denotes numerous
T8400 7900-7912 NNS denotes mitochondria
T8401 7913-7914 -LRB- denotes (
T8402 7916-7925 VBN denotes indicated
T8403 7914-7915 NN denotes m
T8404 7926-7928 IN denotes by
T8405 7929-7934 NN denotes arrow
T8406 7934-7935 -RRB- denotes )
T8407 7936-7938 IN denotes as
T8408 7939-7941 IN denotes in
T8409 7942-7945 NN denotes Crx
T8410 7945-7946 SYM denotes +
T8411 7946-7947 HYPH denotes /
T8412 7947-7948 SYM denotes +
T8413 7949-7950 -LRB- denotes (
T8414 7950-7956 NN denotes Figure
T8415 7957-7959 CD denotes 1A
T8416 7959-7960 -RRB- denotes )
T8417 7960-7961 . denotes .
T8418 7961-7987 sentence denotes pe, pigmented epithelium.
T8419 7962-7964 NN denotes pe
T8420 7964-7966 , denotes ,
T8421 7966-7975 JJ denotes pigmented
T8422 7976-7986 NN denotes epithelium
T8423 7986-7987 . denotes .
T8424 7987-8007 sentence denotes is, inner segments.
T8425 7988-7990 NN denotes is
T8426 7990-7992 , denotes ,
T8427 7992-7997 JJ denotes inner
T8428 7998-8006 NNS denotes segments
T8429 8006-8007 . denotes .
T8430 8007-8033 sentence denotes onl, outer nuclear layer.
T8431 8008-8011 NN denotes onl
T8432 8011-8013 , denotes ,
T8433 8013-8018 JJ denotes outer
T8434 8027-8032 NN denotes layer
T8435 8019-8026 JJ denotes nuclear
T8436 8032-8033 . denotes .
T8437 8033-8051 sentence denotes Scale bar = 2 μm.
T8438 8034-8039 NN denotes Scale
T8439 8040-8043 NN denotes bar
T8440 8048-8050 NN denotes μm
T8441 8044-8045 SYM denotes =
T8442 8046-8047 CD denotes 2
T8443 8050-8051 . denotes .
T8570 8940-8952 NN denotes Transmission
T8571 8962-8972 NN denotes micrograph
T8572 8953-8961 NN denotes electron
T8573 8973-8975 IN denotes of
T8574 8976-8979 NN denotes Crx
T8575 8983-8989 NN denotes retina
T8576 8979-8980 SYM denotes -
T8577 8980-8981 HYPH denotes /
T8578 8981-8982 SYM denotes -
T8579 8990-8992 IN denotes at
T8580 8993-8996 NN denotes P21
T8581 8997-8998 -LRB- denotes (
T8582 8998-8999 NN denotes A
T8583 9000-9003 CC denotes and
T8584 9004-9005 NN denotes B
T8585 9005-9006 -RRB- denotes )
T8586 9006-9008 , denotes ,
T8587 9008-9011 CC denotes and
T8588 9012-9020 VBG denotes scanning
T8589 9030-9040 NN denotes micrograph
T8590 9021-9029 NN denotes electron
T8591 9041-9043 IN denotes of
T8592 9044-9047 NN denotes Crx
T8593 9047-9048 SYM denotes -
T8594 9048-9049 HYPH denotes /
T8595 9049-9050 SYM denotes -
T8596 9051-9053 IN denotes at
T8597 9054-9057 NN denotes P10
T8598 9058-9059 -LRB- denotes (
T8599 9059-9060 NN denotes C
T8600 9060-9061 -RRB- denotes )
T8601 9062-9064 IN denotes of
T8602 9065-9070 JJ denotes outer
T8603 9071-9078 NN denotes segment
T8604 9079-9084 NN denotes layer
T8605 9084-9085 . denotes .
T8606 9085-9159 sentence denotes (A) Evidence of ciliogenesis in the photoreceptor layer of Crx-/- retina.
T8607 9086-9087 -LRB- denotes (
T8608 9087-9088 LS denotes A
T8609 9090-9098 NN denotes Evidence
T8610 9088-9089 -RRB- denotes )
T8611 9099-9101 IN denotes of
T8612 9102-9114 NN denotes ciliogenesis
T8613 9115-9117 IN denotes in
T8614 9118-9121 DT denotes the
T8615 9136-9141 NN denotes layer
T8616 9122-9135 NN denotes photoreceptor
T8617 9142-9144 IN denotes of
T8618 9145-9148 NN denotes Crx
T8619 9152-9158 NN denotes retina
T8620 9148-9149 SYM denotes -
T8621 9149-9150 HYPH denotes /
T8622 9150-9151 SYM denotes -
T8623 9158-9159 . denotes .
T8624 9159-9256 sentence denotes Nonmotile connecting cilia were observed in cross section (arrowheads 1,2, and 3, for examples).
T8625 9160-9169 JJ denotes Nonmotile
T8626 9181-9186 NNS denotes cilia
T8627 9170-9180 VBG denotes connecting
T8628 9192-9200 VBN denotes observed
T8629 9187-9191 VBD denotes were
T8630 9201-9203 IN denotes in
T8631 9204-9209 NN denotes cross
T8632 9210-9217 NN denotes section
T8633 9218-9219 -LRB- denotes (
T8634 9230-9231 CD denotes 1
T8635 9219-9229 NNS denotes arrowheads
T8636 9231-9232 , denotes ,
T8637 9232-9233 CD denotes 2
T8638 9233-9235 , denotes ,
T8639 9235-9238 CC denotes and
T8640 9239-9240 CD denotes 3
T8641 9240-9242 , denotes ,
T8642 9242-9245 IN denotes for
T8643 9246-9254 NNS denotes examples
T8644 9254-9255 -RRB- denotes )
T8645 9255-9256 . denotes .
T8646 9256-9374 sentence denotes Connecting cilium 1 (arrowhead 1) demonstrated seven microtuble doublets, while cilium 2 and cilium 3 exhibited nine.
T8647 9257-9267 VBG denotes Connecting
T8648 9268-9274 NN denotes cilium
T8649 9291-9303 VBD denotes demonstrated
T8650 9275-9276 CD denotes 1
T8651 9277-9278 -LRB- denotes (
T8652 9278-9287 NN denotes arrowhead
T8653 9288-9289 CD denotes 1
T8654 9289-9290 -RRB- denotes )
T8655 9304-9309 CD denotes seven
T8656 9321-9329 NNS denotes doublets
T8657 9310-9320 JJ denotes microtuble
T8658 9329-9331 , denotes ,
T8659 9331-9336 IN denotes while
T8660 9359-9368 VBD denotes exhibited
T8661 9337-9343 NN denotes cilium
T8662 9344-9345 CD denotes 2
T8663 9346-9349 CC denotes and
T8664 9350-9356 NN denotes cilium
T8665 9357-9358 CD denotes 3
T8666 9369-9373 CD denotes nine
T8667 9373-9374 . denotes .
T8668 9374-9649 sentence denotes In A, a displaced cell nucleus (n) appearing pyknotic and abnormal deposition of matrix (mx) material of unknown identity were seen, along with large amounts of membranous vesicles (arrow) which filled the photoreceptor space and appeared to be released from inner segments.
T8669 9375-9377 IN denotes In
T8670 9502-9506 VBN denotes seen
T8671 9378-9379 NN denotes A
T8672 9379-9381 , denotes ,
T8673 9381-9382 DT denotes a
T8674 9398-9405 NN denotes nucleus
T8675 9383-9392 VBN denotes displaced
T8676 9393-9397 NN denotes cell
T8677 9406-9407 -LRB- denotes (
T8678 9407-9408 NN denotes n
T8679 9408-9409 -RRB- denotes )
T8680 9410-9419 VBG denotes appearing
T8681 9420-9428 JJ denotes pyknotic
T8682 9429-9432 CC denotes and
T8683 9433-9441 JJ denotes abnormal
T8684 9442-9452 NN denotes deposition
T8685 9453-9455 IN denotes of
T8686 9456-9462 NN denotes matrix
T8687 9468-9476 NN denotes material
T8688 9463-9464 -LRB- denotes (
T8689 9464-9466 NN denotes mx
T8690 9466-9467 -RRB- denotes )
T8691 9477-9479 IN denotes of
T8692 9480-9487 JJ denotes unknown
T8693 9488-9496 NN denotes identity
T8694 9497-9501 VBD denotes were
T8695 9506-9508 , denotes ,
T8696 9508-9513 IN denotes along
T8697 9514-9518 IN denotes with
T8698 9519-9524 JJ denotes large
T8699 9525-9532 NNS denotes amounts
T8700 9533-9535 IN denotes of
T8701 9536-9546 JJ denotes membranous
T8702 9547-9555 NNS denotes vesicles
T8703 9556-9557 -LRB- denotes (
T8704 9557-9562 NN denotes arrow
T8705 9562-9563 -RRB- denotes )
T8706 9564-9569 WDT denotes which
T8707 9570-9576 VBD denotes filled
T8708 9577-9580 DT denotes the
T8709 9595-9600 NN denotes space
T8710 9581-9594 NN denotes photoreceptor
T8711 9601-9604 CC denotes and
T8712 9605-9613 VBD denotes appeared
T8713 9614-9616 TO denotes to
T8714 9620-9628 VBN denotes released
T8715 9617-9619 VB denotes be
T8716 9629-9633 IN denotes from
T8717 9634-9639 JJ denotes inner
T8718 9640-9648 NNS denotes segments
T8719 9648-9649 . denotes .
T8720 9649-9669 sentence denotes Scale bar = 3.7 μm.
T8721 9650-9655 NN denotes Scale
T8722 9656-9659 NN denotes bar
T8723 9666-9668 NN denotes μm
T8724 9660-9661 SYM denotes =
T8725 9662-9665 CD denotes 3.7
T8726 9668-9669 . denotes .
T8727 9669-9819 sentence denotes (B) Nonmotile connecting cilium in cross section, from a Crx-/- photoreceptor, demonstrating characteristic 9+0 radial array of microtubule doublets.
T8728 9670-9671 -LRB- denotes (
T8729 9671-9672 LS denotes B
T8730 9695-9701 NN denotes cilium
T8731 9672-9673 -RRB- denotes )
T8732 9674-9683 JJ denotes Nonmotile
T8733 9684-9694 VBG denotes connecting
T8734 9702-9704 IN denotes in
T8735 9705-9710 NN denotes cross
T8736 9711-9718 NN denotes section
T8737 9718-9720 , denotes ,
T8738 9720-9724 IN denotes from
T8739 9725-9726 DT denotes a
T8740 9734-9747 NN denotes photoreceptor
T8741 9727-9730 NN denotes Crx
T8742 9730-9731 SYM denotes -
T8743 9731-9732 HYPH denotes /
T8744 9732-9733 SYM denotes -
T8745 9747-9749 , denotes ,
T8746 9749-9762 VBG denotes demonstrating
T8747 9763-9777 JJ denotes characteristic
T8748 9789-9794 NN denotes array
T8749 9778-9779 CD denotes 9
T8750 9780-9781 CD denotes 0
T8751 9779-9780 SYM denotes +
T8752 9782-9788 JJ denotes radial
T8753 9795-9797 IN denotes of
T8754 9798-9809 NN denotes microtubule
T8755 9810-9818 NNS denotes doublets
T8756 9818-9819 . denotes .
T8757 9819-9838 sentence denotes Scale bar = 88 nm.
T8758 9820-9825 NN denotes Scale
T8759 9826-9829 NN denotes bar
T8760 9835-9837 NN denotes nm
T8761 9830-9831 SYM denotes =
T8762 9832-9834 CD denotes 88
T8763 9837-9838 . denotes .
T8764 9838-9984 sentence denotes (C) Scanning electron micrograph (SEM) of membranous vesicles (arrow shows one example) shed from inner segments of Crx-/- photoreceptors at P10.
T8765 9839-9840 -LRB- denotes (
T8766 9840-9841 LS denotes C
T8767 9861-9871 NN denotes micrograph
T8768 9841-9842 -RRB- denotes )
T8769 9843-9851 VBG denotes Scanning
T8770 9852-9860 NN denotes electron
T8771 9872-9873 -LRB- denotes (
T8772 9873-9876 NN denotes SEM
T8773 9876-9877 -RRB- denotes )
T8774 9878-9880 IN denotes of
T8775 9881-9891 JJ denotes membranous
T8776 9892-9900 NNS denotes vesicles
T8777 9901-9902 -LRB- denotes (
T8778 9908-9913 VBZ denotes shows
T8779 9902-9907 NN denotes arrow
T8780 9914-9917 CD denotes one
T8781 9918-9925 NN denotes example
T8782 9925-9926 -RRB- denotes )
T8783 9927-9931 VBN denotes shed
T8784 9932-9936 IN denotes from
T8785 9937-9942 JJ denotes inner
T8786 9943-9951 NNS denotes segments
T8787 9952-9954 IN denotes of
T8788 9955-9958 NN denotes Crx
T8789 9962-9976 NNS denotes photoreceptors
T8790 9958-9959 SYM denotes -
T8791 9959-9960 HYPH denotes /
T8792 9960-9961 SYM denotes -
T8793 9977-9979 IN denotes at
T8794 9980-9983 NN denotes P10
T8795 9983-9984 . denotes .
T8796 9984-10080 sentence denotes Figure shows inner segments viewed from the scleral side with the pigmented epithelium removed.
T8797 9985-9991 NN denotes Figure
T8798 9992-9997 VBZ denotes shows
T8799 9998-10003 JJ denotes inner
T8800 10004-10012 NNS denotes segments
T8801 10013-10019 VBN denotes viewed
T8802 10020-10024 IN denotes from
T8803 10025-10028 DT denotes the
T8804 10037-10041 NN denotes side
T8805 10029-10036 JJ denotes scleral
T8806 10042-10046 IN denotes with
T8807 10072-10079 VBN denotes removed
T8808 10047-10050 DT denotes the
T8809 10061-10071 NN denotes epithelium
T8810 10051-10060 VBN denotes pigmented
T8811 10079-10080 . denotes .
T8812 10080-10098 sentence denotes Scale bar = 1 μm.
T8813 10081-10086 NN denotes Scale
T8814 10087-10090 NN denotes bar
T8815 10095-10097 NN denotes μm
T8816 10091-10092 SYM denotes =
T8817 10093-10094 CD denotes 1
T8818 10097-10098 . denotes .
T8923 12753-12758 NN denotes Outer
T8924 12759-12766 NN denotes segment
T8925 12767-12780 NN denotes morphogenesis
T8926 12781-12783 IN denotes in
T8927 12784-12787 NN denotes Crx
T8928 12791-12805 NNS denotes photoreceptors
T8929 12787-12788 SYM denotes -
T8930 12788-12789 HYPH denotes /
T8931 12789-12790 SYM denotes -
T8932 12805-12806 . denotes .
T8933 12806-13010 sentence denotes Scanning electron microscopy of developing photoreceptors viewed from the scleral side with the pigmented epithelium removed at P7, P14, and P21 for Crx+/+ (A, C, and E) and Crx-/- (B, D, F) littermates.
T8934 12807-12815 VBG denotes Scanning
T8935 12825-12835 NN denotes microscopy
T8936 12816-12824 NN denotes electron
T8937 12836-12838 IN denotes of
T8938 12839-12849 VBG denotes developing
T8939 12850-12864 NNS denotes photoreceptors
T8940 12865-12871 VBN denotes viewed
T8941 12872-12876 IN denotes from
T8942 12877-12880 DT denotes the
T8943 12889-12893 NN denotes side
T8944 12881-12888 JJ denotes scleral
T8945 12894-12898 IN denotes with
T8946 12924-12931 VBN denotes removed
T8947 12899-12902 DT denotes the
T8948 12913-12923 NN denotes epithelium
T8949 12903-12912 JJ denotes pigmented
T8950 12932-12934 IN denotes at
T8951 12935-12937 NN denotes P7
T8952 12937-12939 , denotes ,
T8953 12939-12942 NN denotes P14
T8954 12942-12944 , denotes ,
T8955 12944-12947 CC denotes and
T8956 12948-12951 NN denotes P21
T8957 12952-12955 IN denotes for
T8958 12956-12959 NN denotes Crx
T8959 12998-13009 NNS denotes littermates
T8960 12959-12960 SYM denotes +
T8961 12960-12961 HYPH denotes /
T8962 12961-12962 SYM denotes +
T8963 12963-12964 -LRB- denotes (
T8964 12964-12965 NN denotes A
T8965 12965-12967 , denotes ,
T8966 12967-12968 NN denotes C
T8967 12968-12970 , denotes ,
T8968 12970-12973 CC denotes and
T8969 12974-12975 NN denotes E
T8970 12975-12976 -RRB- denotes )
T8971 12977-12980 CC denotes and
T8972 12981-12984 NN denotes Crx
T8973 12984-12985 SYM denotes -
T8974 12985-12986 HYPH denotes /
T8975 12986-12987 SYM denotes -
T8976 12988-12989 -LRB- denotes (
T8977 12995-12996 NN denotes F
T8978 12989-12990 NN denotes B
T8979 12990-12992 , denotes ,
T8980 12992-12993 NN denotes D
T8981 12993-12995 , denotes ,
T8982 12996-12997 -RRB- denotes )
T8983 13009-13010 . denotes .
T8984 13010-13114 sentence denotes In Crx+/+ retina, numerous connecting cilia (A, cc) were evident at P7 with rudimentary outer segments.
T8985 13011-13013 IN denotes In
T8986 13063-13067 VBD denotes were
T8987 13014-13017 NN denotes Crx
T8988 13021-13027 NN denotes retina
T8989 13017-13018 SYM denotes +
T8990 13018-13019 HYPH denotes /
T8991 13019-13020 SYM denotes +
T8992 13027-13029 , denotes ,
T8993 13029-13037 JJ denotes numerous
T8994 13049-13054 NNS denotes cilia
T8995 13038-13048 VBG denotes connecting
T8996 13055-13056 -LRB- denotes (
T8997 13059-13061 NN denotes cc
T8998 13056-13057 NN denotes A
T8999 13057-13059 , denotes ,
T9000 13061-13062 -RRB- denotes )
T9001 13068-13075 JJ denotes evident
T9002 13076-13078 IN denotes at
T9003 13079-13081 NN denotes P7
T9004 13082-13086 IN denotes with
T9005 13087-13098 JJ denotes rudimentary
T9006 13105-13113 NNS denotes segments
T9007 13099-13104 JJ denotes outer
T9008 13113-13114 . denotes .
T9009 13114-13167 sentence denotes After P7, in Crx+/+ outer segment elongation occurs.
T9010 13115-13120 IN denotes After
T9011 13160-13166 VBZ denotes occurs
T9012 13121-13123 NN denotes P7
T9013 13123-13125 , denotes ,
T9014 13125-13127 IN denotes in
T9015 13128-13131 NN denotes Crx
T9016 13131-13132 SYM denotes +
T9017 13132-13133 HYPH denotes /
T9018 13133-13134 SYM denotes +
T9019 13135-13140 JJ denotes outer
T9020 13141-13148 NN denotes segment
T9021 13149-13159 NN denotes elongation
T9022 13166-13167 . denotes .
T9023 13167-13259 sentence denotes Initially, outer segments have a paddle-like structure (C, os) which is later shed (E, os).
T9024 13168-13177 RB denotes Initially
T9025 13194-13198 VBP denotes have
T9026 13177-13179 , denotes ,
T9027 13179-13184 JJ denotes outer
T9028 13185-13193 NNS denotes segments
T9029 13199-13200 DT denotes a
T9030 13213-13222 NN denotes structure
T9031 13201-13207 NN denotes paddle
T9032 13208-13212 JJ denotes like
T9033 13207-13208 HYPH denotes -
T9034 13223-13224 -LRB- denotes (
T9035 13227-13229 NN denotes os
T9036 13224-13225 NN denotes C
T9037 13225-13227 , denotes ,
T9038 13229-13230 -RRB- denotes )
T9039 13231-13236 WDT denotes which
T9040 13246-13250 VBN denotes shed
T9041 13237-13239 VBZ denotes is
T9042 13240-13245 RB denotes later
T9043 13251-13252 -LRB- denotes (
T9044 13255-13257 NN denotes os
T9045 13252-13253 NN denotes E
T9046 13253-13255 , denotes ,
T9047 13257-13258 -RRB- denotes )
T9048 13258-13259 . denotes .
T9049 13259-13335 sentence denotes In Crx-/- photoreceptors, few connecting cilia were observed at P7 (B, cc).
T9050 13260-13262 IN denotes In
T9051 13312-13320 VBN denotes observed
T9052 13263-13266 NN denotes Crx
T9053 13270-13284 NNS denotes photoreceptors
T9054 13266-13267 SYM denotes -
T9055 13267-13268 HYPH denotes /
T9056 13268-13269 SYM denotes -
T9057 13284-13286 , denotes ,
T9058 13286-13289 JJ denotes few
T9059 13301-13306 NNS denotes cilia
T9060 13290-13300 VBG denotes connecting
T9061 13307-13311 VBD denotes were
T9062 13321-13323 IN denotes at
T9063 13324-13326 NN denotes P7
T9064 13327-13328 -LRB- denotes (
T9065 13331-13333 NN denotes cc
T9066 13328-13329 NN denotes B
T9067 13329-13331 , denotes ,
T9068 13333-13334 -RRB- denotes )
T9069 13334-13335 . denotes .
T9070 13335-13485 sentence denotes After P7, connecting cilia were more numerous and occasionally a malformed outer segment was noted extending from a connecting cilium (D and F, cc*).
T9071 13336-13341 IN denotes After
T9072 13363-13367 VBD denotes were
T9073 13342-13344 NN denotes P7
T9074 13344-13346 , denotes ,
T9075 13346-13356 VBG denotes connecting
T9076 13357-13362 NNS denotes cilia
T9077 13368-13372 RBR denotes more
T9078 13373-13381 JJ denotes numerous
T9079 13382-13385 CC denotes and
T9080 13386-13398 RB denotes occasionally
T9081 13429-13434 VBN denotes noted
T9082 13399-13400 DT denotes a
T9083 13417-13424 NN denotes segment
T9084 13401-13410 JJ denotes malformed
T9085 13411-13416 JJ denotes outer
T9086 13425-13428 VBD denotes was
T9087 13435-13444 VBG denotes extending
T9088 13445-13449 IN denotes from
T9089 13450-13451 DT denotes a
T9090 13463-13469 NN denotes cilium
T9091 13452-13462 VBG denotes connecting
T9092 13470-13471 -LRB- denotes (
T9093 13480-13483 NN denotes cc*
T9094 13471-13472 NN denotes D
T9095 13473-13476 CC denotes and
T9096 13477-13478 NN denotes F
T9097 13478-13480 , denotes ,
T9098 13483-13484 -RRB- denotes )
T9099 13484-13485 . denotes .
T9100 13485-13548 sentence denotes These were rarely observed in Crx+/+ and only at P14 (C, cc*).
T9101 13486-13491 DT denotes These
T9102 13504-13512 VBN denotes observed
T9103 13492-13496 VBD denotes were
T9104 13497-13503 RB denotes rarely
T9105 13513-13515 IN denotes in
T9106 13516-13519 NN denotes Crx
T9107 13519-13520 SYM denotes +
T9108 13520-13521 HYPH denotes /
T9109 13521-13522 SYM denotes +
T9110 13523-13526 CC denotes and
T9111 13527-13531 RB denotes only
T9112 13532-13534 IN denotes at
T9113 13535-13538 NN denotes P14
T9114 13539-13540 -LRB- denotes (
T9115 13543-13546 NN denotes cc*
T9116 13540-13541 NN denotes C
T9117 13541-13543 , denotes ,
T9118 13546-13547 -RRB- denotes )
T9119 13547-13548 . denotes .
T9120 13548-13618 sentence denotes At P21, abnormally long connecting cilia are noted in Crx-/- (F, cc).
T9121 13549-13551 IN denotes At
T9122 13594-13599 VBN denotes noted
T9123 13552-13555 NN denotes P21
T9124 13555-13557 , denotes ,
T9125 13557-13567 RB denotes abnormally
T9126 13568-13572 JJ denotes long
T9127 13584-13589 NNS denotes cilia
T9128 13573-13583 VBG denotes connecting
T9129 13590-13593 VBP denotes are
T9130 13600-13602 IN denotes in
T9131 13603-13606 NN denotes Crx
T9132 13606-13607 SYM denotes -
T9133 13607-13608 HYPH denotes /
T9134 13608-13609 SYM denotes -
T9135 13610-13611 -LRB- denotes (
T9136 13614-13616 NN denotes cc
T9137 13611-13612 NN denotes F
T9138 13612-13614 , denotes ,
T9139 13616-13617 -RRB- denotes )
T9140 13617-13618 . denotes .
T9141 13618-13637 sentence denotes Scale bars = 10 μm
T9142 13619-13624 NN denotes Scale
T9143 13625-13629 NNS denotes bars
T9144 13635-13637 NN denotes μm
T9145 13630-13631 SYM denotes =
T9146 13632-13634 CD denotes 10
T9204 13648-13660 NN denotes Transmission
T9205 13670-13681 NNS denotes micrographs
T9206 13661-13669 NN denotes electron
T9207 13682-13684 IN denotes of
T9208 13685-13688 NN denotes Crx
T9209 13692-13706 NNS denotes photoreceptors
T9210 13688-13689 SYM denotes -
T9211 13689-13690 HYPH denotes /
T9212 13690-13691 SYM denotes -
T9213 13707-13709 IN denotes in
T9214 13710-13713 DT denotes the
T9215 13728-13733 NN denotes layer
T9216 13714-13727 NN denotes photoreceptor
T9217 13734-13736 IN denotes at
T9218 13737-13739 NN denotes P7
T9219 13739-13740 . denotes .
T9220 13740-13887 sentence denotes (A) Photoreceptor layer of Crx+/+ retina demonstrating nascent outer segment structures (arrow) emerging from photoreceptor connecting cilia (cc).
T9221 13741-13742 -LRB- denotes (
T9222 13742-13743 LS denotes A
T9223 13759-13764 NN denotes layer
T9224 13743-13744 -RRB- denotes )
T9225 13745-13758 NN denotes Photoreceptor
T9226 13765-13767 IN denotes of
T9227 13768-13771 NN denotes Crx
T9228 13775-13781 NN denotes retina
T9229 13771-13772 SYM denotes +
T9230 13772-13773 HYPH denotes /
T9231 13773-13774 SYM denotes +
T9232 13782-13795 VBG denotes demonstrating
T9233 13796-13803 JJ denotes nascent
T9234 13818-13828 NNS denotes structures
T9235 13804-13809 JJ denotes outer
T9236 13810-13817 NN denotes segment
T9237 13837-13845 VBG denotes emerging
T9238 13829-13830 -LRB- denotes (
T9239 13830-13835 NN denotes arrow
T9240 13835-13836 -RRB- denotes )
T9241 13846-13850 IN denotes from
T9242 13851-13864 NN denotes photoreceptor
T9243 13876-13881 NNS denotes cilia
T9244 13865-13875 VBG denotes connecting
T9245 13882-13883 -LRB- denotes (
T9246 13883-13885 NN denotes cc
T9247 13885-13886 -RRB- denotes )
T9248 13886-13887 . denotes .
T9249 13887-14027 sentence denotes (B) Crx-/- photoreceptors exhibited connecting cilia (cc) at this early stage, however, nascent outer segment structures were not observed.
T9250 13888-13889 -LRB- denotes (
T9251 13889-13890 LS denotes B
T9252 14018-14026 VBN denotes observed
T9253 13890-13891 -RRB- denotes )
T9254 13892-13895 NN denotes Crx
T9255 13899-13913 NNS denotes photoreceptors
T9256 13895-13896 SYM denotes -
T9257 13896-13897 HYPH denotes /
T9258 13897-13898 SYM denotes -
T9259 13914-13923 VBD denotes exhibited
T9260 13924-13934 VBG denotes connecting
T9261 13935-13940 NNS denotes cilia
T9262 13941-13942 -LRB- denotes (
T9263 13942-13944 NN denotes cc
T9264 13944-13945 -RRB- denotes )
T9265 13946-13948 IN denotes at
T9266 13949-13953 DT denotes this
T9267 13960-13965 NN denotes stage
T9268 13954-13959 JJ denotes early
T9269 13965-13967 , denotes ,
T9270 13967-13974 RB denotes however
T9271 13974-13976 , denotes ,
T9272 13976-13983 JJ denotes nascent
T9273 13998-14008 NNS denotes structures
T9274 13984-13989 JJ denotes outer
T9275 13990-13997 NN denotes segment
T9276 14009-14013 VBD denotes were
T9277 14014-14017 RB denotes not
T9278 14026-14027 . denotes .
T9279 14027-14045 sentence denotes Scale Bar = 1 μm.
T9280 14028-14033 NN denotes Scale
T9281 14034-14037 NN denotes Bar
T9282 14042-14044 NN denotes μm
T9283 14038-14039 SYM denotes =
T9284 14040-14041 CD denotes 1
T9285 14044-14045 . denotes .
T9319 14636-14644 VBG denotes Scanning
T9320 14654-14664 NN denotes microscopy
T9321 14645-14653 NN denotes electron
T9322 14665-14667 IN denotes of
T9323 14668-14678 NN denotes peripherin
T9324 14707-14721 NNS denotes photoreceptors
T9325 14678-14679 SYM denotes -
T9326 14679-14680 HYPH denotes /
T9327 14680-14681 SYM denotes -
T9328 14682-14683 -LRB- denotes (
T9329 14683-14684 NN denotes A
T9330 14684-14685 -RRB- denotes )
T9331 14686-14689 CC denotes and
T9332 14690-14699 NN denotes rhodopsin
T9333 14699-14700 SYM denotes -
T9334 14700-14701 HYPH denotes /
T9335 14701-14702 SYM denotes -
T9336 14703-14704 -LRB- denotes (
T9337 14704-14705 NN denotes B
T9338 14705-14706 -RRB- denotes )
T9339 14722-14724 IN denotes at
T9340 14725-14728 NN denotes P21
T9341 14728-14730 , denotes ,
T9342 14730-14736 VBN denotes viewed
T9343 14737-14741 IN denotes from
T9344 14742-14745 DT denotes the
T9345 14754-14758 NN denotes side
T9346 14746-14753 JJ denotes scleral
T9347 14759-14763 IN denotes with
T9348 14789-14796 VBN denotes removed
T9349 14764-14767 DT denotes the
T9350 14778-14788 NN denotes epithelium
T9351 14768-14777 JJ denotes pigmented
T9352 14796-14797 . denotes .
T9353 14797-14820 sentence denotes cc, connecting cilium.
T9354 14798-14800 NN denotes cc
T9355 14800-14802 , denotes ,
T9356 14802-14812 VBG denotes connecting
T9357 14813-14819 NN denotes cilium
T9358 14819-14820 . denotes .
T9359 14820-14839 sentence denotes is, inner segment.
T9360 14821-14823 NN denotes is
T9361 14823-14825 , denotes ,
T9362 14825-14830 JJ denotes inner
T9363 14831-14838 NN denotes segment
T9364 14838-14839 . denotes .
T9365 14839-14858 sentence denotes Scale bar = 10 μm.
T9366 14840-14845 NN denotes Scale
T9367 14846-14849 NN denotes bar
T9368 14855-14857 NN denotes μm
T9369 14850-14851 SYM denotes =
T9370 14852-14854 CD denotes 10
T9371 14857-14858 . denotes .
T9460 16501-16513 NN denotes Transmission
T9461 16523-16534 NNS denotes micrographs
T9462 16514-16522 NN denotes electron
T9463 16535-16537 IN denotes of
T9464 16538-16541 DT denotes the
T9465 16558-16563 NN denotes layer
T9466 16542-16547 JJ denotes outer
T9467 16548-16557 NN denotes plexiform
T9468 16564-16566 IN denotes in
T9469 16567-16570 NN denotes Crx
T9470 16574-16581 NNS denotes retinas
T9471 16570-16571 SYM denotes -
T9472 16571-16572 HYPH denotes /
T9473 16572-16573 SYM denotes -
T9474 16581-16582 . denotes .
T9475 16582-16686 sentence denotes (A) In Crx+/+ retina at P21, newly formed rod spherules were abundant (arrow demonstrates one example).
T9476 16583-16584 -LRB- denotes (
T9477 16584-16585 LS denotes A
T9478 16639-16643 VBD denotes were
T9479 16585-16586 -RRB- denotes )
T9480 16587-16589 IN denotes In
T9481 16590-16593 NN denotes Crx
T9482 16597-16603 NN denotes retina
T9483 16593-16594 SYM denotes +
T9484 16594-16595 HYPH denotes /
T9485 16595-16596 SYM denotes +
T9486 16604-16606 IN denotes at
T9487 16607-16610 NN denotes P21
T9488 16610-16612 , denotes ,
T9489 16612-16617 RB denotes newly
T9490 16618-16624 VBN denotes formed
T9491 16629-16638 NNS denotes spherules
T9492 16625-16628 NN denotes rod
T9493 16644-16652 JJ denotes abundant
T9494 16653-16654 -LRB- denotes (
T9495 16660-16672 VBZ denotes demonstrates
T9496 16654-16659 NN denotes arrow
T9497 16673-16676 CD denotes one
T9498 16677-16684 NN denotes example
T9499 16684-16685 -RRB- denotes )
T9500 16685-16686 . denotes .
T9501 16686-16786 sentence denotes The spherules were club-shaped and contained a single invaginating synapse with one ribbon complex.
T9502 16687-16690 DT denotes The
T9503 16691-16700 NNS denotes spherules
T9504 16701-16705 VBD denotes were
T9505 16706-16710 NN denotes club
T9506 16711-16717 VBN denotes shaped
T9507 16710-16711 HYPH denotes -
T9508 16718-16721 CC denotes and
T9509 16722-16731 VBD denotes contained
T9510 16732-16733 DT denotes a
T9511 16754-16761 NN denotes synapse
T9512 16734-16740 JJ denotes single
T9513 16741-16753 VBG denotes invaginating
T9514 16762-16766 IN denotes with
T9515 16767-16770 CD denotes one
T9516 16778-16785 NN denotes complex
T9517 16771-16777 NN denotes ribbon
T9518 16785-16786 . denotes .
T9519 16786-16900 sentence denotes Cone terminals form large, flat pedicles that contain many invaginating synapses with separate ribbon structures.
T9520 16787-16791 NN denotes Cone
T9521 16792-16801 NNS denotes terminals
T9522 16802-16806 VBP denotes form
T9523 16807-16812 JJ denotes large
T9524 16819-16827 NNS denotes pedicles
T9525 16812-16814 , denotes ,
T9526 16814-16818 JJ denotes flat
T9527 16828-16832 WDT denotes that
T9528 16833-16840 VBP denotes contain
T9529 16841-16845 JJ denotes many
T9530 16859-16867 NNS denotes synapses
T9531 16846-16858 VBG denotes invaginating
T9532 16868-16872 IN denotes with
T9533 16873-16881 JJ denotes separate
T9534 16889-16899 NNS denotes structures
T9535 16882-16888 NN denotes ribbon
T9536 16899-16900 . denotes .
T9537 16900-16994 sentence denotes These terminals were more scarce, but apparent in Crx+/+ retinas at P21 (one example in box).
T9538 16901-16906 DT denotes These
T9539 16907-16916 NNS denotes terminals
T9540 16917-16921 VBD denotes were
T9541 16922-16926 RBR denotes more
T9542 16927-16933 JJ denotes scarce
T9543 16933-16935 , denotes ,
T9544 16935-16938 CC denotes but
T9545 16939-16947 JJ denotes apparent
T9546 16948-16950 IN denotes in
T9547 16951-16954 NN denotes Crx
T9548 16958-16965 NNS denotes retinas
T9549 16954-16955 SYM denotes +
T9550 16955-16956 HYPH denotes /
T9551 16956-16957 SYM denotes +
T9552 16966-16968 IN denotes at
T9553 16969-16972 NN denotes P21
T9554 16973-16974 -LRB- denotes (
T9555 16978-16985 NN denotes example
T9556 16974-16977 CD denotes one
T9557 16986-16988 IN denotes in
T9558 16989-16992 NN denotes box
T9559 16992-16993 -RRB- denotes )
T9560 16993-16994 . denotes .
T9561 16994-17122 sentence denotes (B) In the outer plexiform layer (OPL) of Crx-/- retinas, photoreceptor terminals appeared highly disorganized at P21 (arrows).
T9562 16995-16996 -LRB- denotes (
T9563 16996-16997 LS denotes B
T9564 17077-17085 VBD denotes appeared
T9565 16997-16998 -RRB- denotes )
T9566 16999-17001 IN denotes In
T9567 17002-17005 DT denotes the
T9568 17022-17027 NN denotes layer
T9569 17006-17011 JJ denotes outer
T9570 17012-17021 NN denotes plexiform
T9571 17028-17029 -LRB- denotes (
T9572 17029-17032 NN denotes OPL
T9573 17032-17033 -RRB- denotes )
T9574 17034-17036 IN denotes of
T9575 17037-17040 NN denotes Crx
T9576 17044-17051 NNS denotes retinas
T9577 17040-17041 SYM denotes -
T9578 17041-17042 HYPH denotes /
T9579 17042-17043 SYM denotes -
T9580 17051-17053 , denotes ,
T9581 17053-17066 NN denotes photoreceptor
T9582 17067-17076 NNS denotes terminals
T9583 17086-17092 RB denotes highly
T9584 17093-17105 JJ denotes disorganized
T9585 17106-17108 IN denotes at
T9586 17109-17112 NN denotes P21
T9587 17113-17114 -LRB- denotes (
T9588 17114-17120 NNS denotes arrows
T9589 17120-17121 -RRB- denotes )
T9590 17121-17122 . denotes .
T9591 17122-17175 sentence denotes Well-formed pedicles and spherules were not evident.
T9592 17123-17127 RB denotes Well
T9593 17128-17134 VBN denotes formed
T9594 17127-17128 HYPH denotes -
T9595 17135-17143 NNS denotes pedicles
T9596 17158-17162 VBD denotes were
T9597 17144-17147 CC denotes and
T9598 17148-17157 NNS denotes spherules
T9599 17163-17166 RB denotes not
T9600 17167-17174 JJ denotes evident
T9601 17174-17175 . denotes .
T9602 17175-17305 sentence denotes Putative terminals containing ribbon-like structures were apparent, suggesting at least limited generation of synapse components.
T9603 17176-17184 JJ denotes Putative
T9604 17185-17194 NNS denotes terminals
T9605 17229-17233 VBD denotes were
T9606 17195-17205 VBG denotes containing
T9607 17206-17212 NN denotes ribbon
T9608 17213-17217 JJ denotes like
T9609 17212-17213 HYPH denotes -
T9610 17218-17228 NNS denotes structures
T9611 17234-17242 JJ denotes apparent
T9612 17242-17244 , denotes ,
T9613 17244-17254 VBG denotes suggesting
T9614 17255-17257 RB denotes at
T9615 17258-17263 RBS denotes least
T9616 17264-17271 JJ denotes limited
T9617 17272-17282 NN denotes generation
T9618 17283-17285 IN denotes of
T9619 17286-17293 NN denotes synapse
T9620 17294-17304 NNS denotes components
T9621 17304-17305 . denotes .
T9622 17305-17402 sentence denotes Many terminals appeared to contain multiple ribbon-like structures, instead of a singule ribbon.
T9623 17306-17310 JJ denotes Many
T9624 17311-17320 NNS denotes terminals
T9625 17321-17329 VBD denotes appeared
T9626 17330-17332 TO denotes to
T9627 17333-17340 VB denotes contain
T9628 17341-17349 JJ denotes multiple
T9629 17362-17372 NNS denotes structures
T9630 17350-17356 NN denotes ribbon
T9631 17357-17361 JJ denotes like
T9632 17356-17357 HYPH denotes -
T9633 17372-17374 , denotes ,
T9634 17374-17381 RB denotes instead
T9635 17382-17384 IN denotes of
T9636 17385-17386 DT denotes a
T9637 17395-17401 NN denotes ribbon
T9638 17387-17394 JJ denotes singule
T9639 17401-17402 . denotes .
T9640 17402-17509 sentence denotes For example, terminal 1 and 2 contained two ribbons each, whereas terminal 3 appeared to contain only one.
T9641 17403-17406 IN denotes For
T9642 17433-17442 VBD denotes contained
T9643 17407-17414 NN denotes example
T9644 17414-17416 , denotes ,
T9645 17416-17424 NN denotes terminal
T9646 17425-17426 CD denotes 1
T9647 17427-17430 CC denotes and
T9648 17431-17432 CD denotes 2
T9649 17443-17446 CD denotes two
T9650 17447-17454 NNS denotes ribbons
T9651 17455-17459 DT denotes each
T9652 17459-17461 , denotes ,
T9653 17461-17468 IN denotes whereas
T9654 17480-17488 VBD denotes appeared
T9655 17469-17477 NN denotes terminal
T9656 17478-17479 CD denotes 3
T9657 17489-17491 TO denotes to
T9658 17492-17499 VB denotes contain
T9659 17500-17504 RB denotes only
T9660 17505-17508 CD denotes one
T9661 17508-17509 . denotes .
T9662 17509-17537 sentence denotes opl, outer plexiform layer.
T9663 17510-17513 NN denotes opl
T9664 17513-17515 , denotes ,
T9665 17515-17520 JJ denotes outer
T9666 17531-17536 NN denotes layer
T9667 17521-17530 NN denotes plexiform
T9668 17536-17537 . denotes .
T9669 17537-17555 sentence denotes Scale bar = 2 μm.
T9670 17538-17543 NN denotes Scale
T9671 17544-17547 NN denotes bar
T9672 17552-17554 NN denotes μm
T9673 17548-17549 SYM denotes =
T9674 17550-17551 CD denotes 2
T9675 17554-17555 . denotes .
T9811 17566-17578 NN denotes Transmission
T9812 17588-17599 NNS denotes micrographs
T9813 17579-17587 NN denotes electron
T9814 17600-17602 IN denotes of
T9815 17603-17606 DT denotes the
T9816 17623-17628 NN denotes layer
T9817 17607-17612 JJ denotes outer
T9818 17613-17622 NN denotes plexiform
T9819 17629-17631 IN denotes in
T9820 17632-17635 NN denotes Crx
T9821 17639-17646 NNS denotes retinas
T9822 17635-17636 SYM denotes -
T9823 17636-17637 HYPH denotes /
T9824 17637-17638 SYM denotes -
T9825 17647-17649 IN denotes at
T9826 17650-17653 NN denotes P21
T9827 17653-17654 . denotes .
T9828 17654-17744 sentence denotes (A) Crx+/+ rod spherules contained a single invaginating synapse with one ribbon complex.
T9829 17655-17656 -LRB- denotes (
T9830 17656-17657 LS denotes A
T9831 17680-17689 VBD denotes contained
T9832 17657-17658 -RRB- denotes )
T9833 17659-17662 NN denotes Crx
T9834 17670-17679 NNS denotes spherules
T9835 17662-17663 SYM denotes +
T9836 17663-17664 HYPH denotes /
T9837 17664-17665 SYM denotes +
T9838 17666-17669 NN denotes rod
T9839 17690-17691 DT denotes a
T9840 17712-17719 NN denotes synapse
T9841 17692-17698 JJ denotes single
T9842 17699-17711 VBG denotes invaginating
T9843 17720-17724 IN denotes with
T9844 17725-17728 CD denotes one
T9845 17736-17743 NN denotes complex
T9846 17729-17735 NN denotes ribbon
T9847 17743-17744 . denotes .
T9848 17744-17795 sentence denotes The spherule was a blunt or club-shaped structure.
T9849 17745-17748 DT denotes The
T9850 17749-17757 NN denotes spherule
T9851 17758-17761 VBD denotes was
T9852 17762-17763 DT denotes a
T9853 17785-17794 NN denotes structure
T9854 17764-17769 JJ denotes blunt
T9855 17770-17772 CC denotes or
T9856 17773-17777 NN denotes club
T9857 17778-17784 VBN denotes shaped
T9858 17777-17778 HYPH denotes -
T9859 17794-17795 . denotes .
T9860 17795-17861 sentence denotes (B) Crx+/+ rod terminals contained a single ribbon structure (r).
T9861 17796-17797 -LRB- denotes (
T9862 17797-17798 LS denotes B
T9863 17821-17830 VBD denotes contained
T9864 17798-17799 -RRB- denotes )
T9865 17800-17803 NN denotes Crx
T9866 17811-17820 NNS denotes terminals
T9867 17803-17804 SYM denotes +
T9868 17804-17805 HYPH denotes /
T9869 17805-17806 SYM denotes +
T9870 17807-17810 NN denotes rod
T9871 17831-17832 DT denotes a
T9872 17847-17856 NN denotes structure
T9873 17833-17839 JJ denotes single
T9874 17840-17846 NN denotes ribbon
T9875 17857-17858 -LRB- denotes (
T9876 17858-17859 NN denotes r
T9877 17859-17860 -RRB- denotes )
T9878 17860-17861 . denotes .
T9879 17861-17932 sentence denotes Two processes, from horizontal cells (h), contacted the rod laterally.
T9880 17862-17865 CD denotes Two
T9881 17866-17875 NNS denotes processes
T9882 17904-17913 VBD denotes contacted
T9883 17875-17877 , denotes ,
T9884 17877-17881 IN denotes from
T9885 17882-17892 JJ denotes horizontal
T9886 17893-17898 NNS denotes cells
T9887 17899-17900 -LRB- denotes (
T9888 17900-17901 NN denotes h
T9889 17901-17902 -RRB- denotes )
T9890 17902-17904 , denotes ,
T9891 17914-17917 DT denotes the
T9892 17918-17921 NN denotes rod
T9893 17922-17931 RB denotes laterally
T9894 17931-17932 . denotes .
T9895 17932-18023 sentence denotes An additional process, the postsynaptic bipolar dendrite (b), was situated more centrally.
T9896 17933-17935 DT denotes An
T9897 17947-17954 NN denotes process
T9898 17936-17946 JJ denotes additional
T9899 17999-18007 VBN denotes situated
T9900 17954-17956 , denotes ,
T9901 17956-17959 DT denotes the
T9902 17981-17989 NN denotes dendrite
T9903 17960-17972 JJ denotes postsynaptic
T9904 17973-17980 JJ denotes bipolar
T9905 17990-17991 -LRB- denotes (
T9906 17991-17992 NN denotes b
T9907 17992-17993 -RRB- denotes )
T9908 17993-17995 , denotes ,
T9909 17995-17998 VBD denotes was
T9910 18008-18012 RBR denotes more
T9911 18013-18022 RB denotes centrally
T9912 18022-18023 . denotes .
T9913 18023-18069 sentence denotes Terminals were filled with synaptic vesicles.
T9914 18024-18033 NNS denotes Terminals
T9915 18039-18045 VBN denotes filled
T9916 18034-18038 VBD denotes were
T9917 18046-18050 IN denotes with
T9918 18051-18059 JJ denotes synaptic
T9919 18060-18068 NNS denotes vesicles
T9920 18068-18069 . denotes .
T9921 18069-18145 sentence denotes One coated vesicle originatinf from the cell membrane was observed (arrow).
T9922 18070-18073 CD denotes One
T9923 18081-18088 NN denotes vesicle
T9924 18074-18080 JJ denotes coated
T9925 18128-18136 VBN denotes observed
T9926 18089-18100 VBG denotes originatinf
T9927 18101-18105 IN denotes from
T9928 18106-18109 DT denotes the
T9929 18115-18123 NN denotes membrane
T9930 18110-18114 NN denotes cell
T9931 18124-18127 VBD denotes was
T9932 18137-18138 -LRB- denotes (
T9933 18138-18143 NN denotes arrow
T9934 18143-18144 -RRB- denotes )
T9935 18144-18145 . denotes .
T9936 18145-18233 sentence denotes (C) In the OPL of Crx-/- retinas, photoreceptor terminals appeared highly disorganized.
T9937 18146-18147 -LRB- denotes (
T9938 18147-18148 LS denotes C
T9939 18204-18212 VBD denotes appeared
T9940 18148-18149 -RRB- denotes )
T9941 18150-18152 IN denotes In
T9942 18153-18156 DT denotes the
T9943 18157-18160 NN denotes OPL
T9944 18161-18163 IN denotes of
T9945 18164-18167 NN denotes Crx
T9946 18171-18178 NNS denotes retinas
T9947 18167-18168 SYM denotes -
T9948 18168-18169 HYPH denotes /
T9949 18169-18170 SYM denotes -
T9950 18178-18180 , denotes ,
T9951 18180-18193 NN denotes photoreceptor
T9952 18194-18203 NNS denotes terminals
T9953 18213-18219 RB denotes highly
T9954 18220-18232 JJ denotes disorganized
T9955 18232-18233 . denotes .
T9956 18233-18394 sentence denotes Putative terminals containing synaptic vesicles and ribbon-like structures were apparent (arrows), suggesting at least limited generation of synapse components.
T9957 18234-18242 JJ denotes Putative
T9958 18243-18252 NNS denotes terminals
T9959 18309-18313 VBD denotes were
T9960 18253-18263 VBG denotes containing
T9961 18264-18272 JJ denotes synaptic
T9962 18273-18281 NNS denotes vesicles
T9963 18282-18285 CC denotes and
T9964 18286-18292 NN denotes ribbon
T9965 18293-18297 JJ denotes like
T9966 18292-18293 HYPH denotes -
T9967 18298-18308 NNS denotes structures
T9968 18314-18322 JJ denotes apparent
T9969 18323-18324 -LRB- denotes (
T9970 18324-18330 NNS denotes arrows
T9971 18330-18331 -RRB- denotes )
T9972 18331-18333 , denotes ,
T9973 18333-18343 VBG denotes suggesting
T9974 18344-18346 RB denotes at
T9975 18347-18352 RBS denotes least
T9976 18353-18360 JJ denotes limited
T9977 18361-18371 NN denotes generation
T9978 18372-18374 IN denotes of
T9979 18375-18382 NN denotes synapse
T9980 18383-18393 NNS denotes components
T9981 18393-18394 . denotes .
T9982 18394-18457 sentence denotes However, well formed spherules and pedicles were not observed.
T9983 18395-18402 RB denotes However
T9984 18448-18456 VBN denotes observed
T9985 18402-18404 , denotes ,
T9986 18404-18408 RB denotes well
T9987 18409-18415 VBN denotes formed
T9988 18416-18425 NNS denotes spherules
T9989 18426-18429 CC denotes and
T9990 18430-18438 NNS denotes pedicles
T9991 18439-18443 VBD denotes were
T9992 18444-18447 RB denotes not
T9993 18456-18457 . denotes .
T9994 18457-18538 sentence denotes Further, many terminals appeared to contain multiple ribbon-like structures (r).
T9995 18458-18465 RB denotes Further
T9996 18482-18490 VBD denotes appeared
T9997 18465-18467 , denotes ,
T9998 18467-18471 JJ denotes many
T9999 18472-18481 NNS denotes terminals
T10000 18491-18493 TO denotes to
T10001 18494-18501 VB denotes contain
T10002 18502-18510 JJ denotes multiple
T10003 18523-18533 NNS denotes structures
T10004 18511-18517 NN denotes ribbon
T10005 18518-18522 JJ denotes like
T10006 18517-18518 HYPH denotes -
T10007 18534-18535 -LRB- denotes (
T10008 18535-18536 NN denotes r
T10009 18536-18537 -RRB- denotes )
T10010 18537-18538 . denotes .
T10011 18538-18706 sentence denotes The majority of these ribbons were not associated with the synaptic membrane, but instead were found free floating and, in some instances, were perinuclear (D, arrow).
T10012 18539-18542 DT denotes The
T10013 18543-18551 NN denotes majority
T10014 18578-18588 VBN denotes associated
T10015 18552-18554 IN denotes of
T10016 18555-18560 DT denotes these
T10017 18561-18568 NNS denotes ribbons
T10018 18569-18573 VBD denotes were
T10019 18574-18577 RB denotes not
T10020 18589-18593 IN denotes with
T10021 18594-18597 DT denotes the
T10022 18607-18615 NN denotes membrane
T10023 18598-18606 JJ denotes synaptic
T10024 18615-18617 , denotes ,
T10025 18617-18620 CC denotes but
T10026 18621-18628 RB denotes instead
T10027 18629-18633 VBD denotes were
T10028 18634-18639 VBN denotes found
T10029 18640-18644 JJ denotes free
T10030 18645-18653 VBG denotes floating
T10031 18654-18657 CC denotes and
T10032 18657-18659 , denotes ,
T10033 18659-18661 IN denotes in
T10034 18678-18682 VBD denotes were
T10035 18662-18666 DT denotes some
T10036 18667-18676 NNS denotes instances
T10037 18676-18678 , denotes ,
T10038 18683-18694 JJ denotes perinuclear
T10039 18695-18696 -LRB- denotes (
T10040 18699-18704 NN denotes arrow
T10041 18696-18697 NN denotes D
T10042 18697-18699 , denotes ,
T10043 18704-18705 -RRB- denotes )
T10044 18705-18706 . denotes .
T10045 18706-18766 sentence denotes H, horizontal cell; B, bipolar cell; N, nucleus; r, ribbon.
T10046 18707-18708 NN denotes H
T10047 18708-18710 , denotes ,
T10048 18710-18720 JJ denotes horizontal
T10049 18721-18725 NN denotes cell
T10050 18725-18726 : denotes ;
T10051 18727-18728 NN denotes B
T10052 18728-18730 , denotes ,
T10053 18730-18737 JJ denotes bipolar
T10054 18738-18742 NN denotes cell
T10055 18742-18743 : denotes ;
T10056 18744-18745 NN denotes N
T10057 18745-18747 , denotes ,
T10058 18747-18754 NN denotes nucleus
T10059 18754-18755 : denotes ;
T10060 18756-18757 NN denotes r
T10061 18757-18759 , denotes ,
T10062 18759-18765 NN denotes ribbon
T10063 18765-18766 . denotes .
T10064 18766-18844 sentence denotes (A) Scale bar = 500 nm, (B) Scale bar = 250 nm, (C and D) Scale bar = 500 nm.
T10065 18767-18768 -LRB- denotes (
T10066 18768-18769 LS denotes A
T10067 18787-18789 NN denotes nm
T10068 18769-18770 -RRB- denotes )
T10069 18771-18776 NN denotes Scale
T10070 18777-18780 NN denotes bar
T10071 18781-18782 SYM denotes =
T10072 18783-18786 CD denotes 500
T10073 18841-18843 NN denotes nm
T10074 18789-18791 , denotes ,
T10075 18791-18792 -LRB- denotes (
T10076 18792-18793 LS denotes B
T10077 18811-18813 NN denotes nm
T10078 18793-18794 -RRB- denotes )
T10079 18795-18800 NN denotes Scale
T10080 18801-18804 NN denotes bar
T10081 18805-18806 SYM denotes =
T10082 18807-18810 CD denotes 250
T10083 18813-18815 , denotes ,
T10084 18815-18816 -LRB- denotes (
T10085 18816-18817 LS denotes C
T10086 18818-18821 CC denotes and
T10087 18822-18823 LS denotes D
T10088 18823-18824 -RRB- denotes )
T10089 18825-18830 NN denotes Scale
T10090 18831-18834 NN denotes bar
T10091 18835-18836 SYM denotes =
T10092 18837-18840 CD denotes 500
T10093 18843-18844 . denotes .
T2556 7367-7369 , denotes ,
T2557 7369-7371 DT denotes an
T2558 7378-7385 NN denotes segment
T2559 7372-7377 JJ denotes inner
T2560 7386-7396 VBG denotes undergoing
T2561 7397-7402 NN denotes lysis
T2562 7403-7406 VBD denotes was
T2563 7412-7414 , denotes ,
T2564 7414-7423 VBG denotes appearing
T2565 7424-7431 VBN denotes swollen
T2566 7432-7434 CC denotes or
T2567 7435-7439 IN denotes with
T2568 7440-7448 NNS denotes vacuoles
T2569 7449-7452 CC denotes and
T2570 7453-7460 VBN denotes swollen
T2571 7461-7473 NNS denotes mitochondria
T2572 7474-7475 -LRB- denotes (
T2573 7484-7489 VBN denotes shown
T2574 7475-7479 NNS denotes data
T115 0-14 NN denotes Synaptogenesis
T2575 7480-7483 RB denotes not
T2576 7489-7490 -RRB- denotes )
T2577 7490-7491 . denotes .
T2578 7491-7492 sentence denotes
T2579 8052-8053 sentence denotes P
T2580 8052-8053 NN denotes P
T2581 8053-8054 sentence denotes h
T2582 8053-8054 NN denotes h
T2583 8054-8056 sentence denotes ot
T2584 8054-8055 NN denotes o
T2585 8055-8056 JJ denotes t
T2586 8056-8067 sentence denotes oreceptor i
T2587 8056-8057 NN denotes o
T2588 8057-8058 JJ denotes r
T2589 8058-8059 JJ denotes e
T2548 7338-7344 NN denotes Figure
T2549 7347-7350 CC denotes and
T2550 7351-7352 CD denotes 2
T2551 7352-7353 -RRB- denotes )
T2552 7353-7354 . denotes .
T2553 7354-7491 sentence denotes Occasionally, an inner segment undergoing lysis was noted, appearing swollen or with vacuoles and swollen mitochondria (data not shown).
T2554 7355-7367 RB denotes Occasionally
T2555 7407-7412 VBN denotes noted
T2590 8059-8065 NN denotes ceptor
T2591 8066-8067 NNS denotes i
T2592 8067-8068 sentence denotes n
T2593 8067-8068 CC denotes n
T2594 8068-8079 sentence denotes ner segment
T2595 8068-8069 NN denotes n
T2596 8069-8071 NN denotes er
T2597 8072-8079 NN denotes segment
T2598 8079-8087 sentence denotes s and ou
T2599 8079-8080 NNS denotes s
T2600 8081-8082 NNS denotes a
T2601 8082-8084 VBN denotes nd
T2602 8085-8086 NN denotes o
T2603 8086-8087 NN denotes u
T2604 8087-8089 sentence denotes te
T2605 8087-8089 JJ denotes te
T2606 8089-8099 sentence denotes r segments
T2607 8089-8090 JJ denotes r
T2608 8091-8099 NNS denotes segments
T2609 8099-8103 sentence denotes are
T2610 8102-8103 NN denotes e
T2611 8100-8102 JJ denotes ar
T2612 8103-8104 sentence denotes
T2613 8104-8247 sentence denotes joined by a non-motile connecting cilium that exhibits a characteristic 9 + 0 arrangement of microtubule doublets when viewed in cross-section.
T2614 8104-8110 VBN denotes joined
T2615 8111-8113 IN denotes by
T2616 8114-8115 DT denotes a
T2617 8138-8144 NN denotes cilium
T2618 8116-8126 JJ denotes non-motile
T2619 8127-8137 JJ denotes connecting
T2620 8145-8149 WDT denotes that
T2621 8150-8158 VBZ denotes exhibits
T2622 8159-8160 DT denotes a
T2623 8182-8193 NN denotes arrangement
T2624 8161-8175 JJ denotes characteristic
T2625 8176-8177 CD denotes 9
T2626 8180-8181 CD denotes 0
T2627 8178-8179 SYM denotes +
T2628 8194-8196 IN denotes of
T2629 8197-8208 NN denotes microtubule
T2630 8209-8217 NNS denotes doublets
T2631 8218-8222 WRB denotes when
T2632 8223-8229 VBN denotes viewed
T2633 8230-8232 IN denotes in
T2634 8233-8246 NN denotes cross-section
T2635 8246-8247 . denotes .
T2636 8247-8349 sentence denotes At P21, in Crx-/- retinas, numerous cross sections of connecting cilia were noted (Figure 3A and 3B).
T2637 8248-8250 IN denotes At
T2638 8324-8329 VBN denotes noted
T2639 8251-8254 NN denotes P21
T2640 8254-8256 , denotes ,
T2747 8786-8793 RB denotes Further
T2748 8851-8859 VBD denotes appeared
T2749 8793-8795 , denotes ,
T2750 8795-8797 IN denotes in
T2751 8798-8801 NN denotes Crx
T2752 8805-8812 NNS denotes retinas
T2753 8801-8802 SYM denotes -
T2754 8802-8803 HYPH denotes /
T2755 8803-8804 SYM denotes -
T2756 8813-8816 DT denotes the
T2757 8835-8845 NN denotes epithelium
T2758 8817-8824 NN denotes retinal
T2759 8825-8834 VBN denotes pigmented
T2760 8846-8847 -LRB- denotes (
T2761 8847-8849 NN denotes PE
T2762 8849-8850 -RRB- denotes )
T2763 8860-8866 JJ denotes normal
T2764 8866-8868 , denotes ,
T2765 8868-8870 RB denotes at
T2766 8871-8876 RBS denotes least
T2767 8877-8879 IN denotes up
T2768 8880-8882 IN denotes to
T2769 8883-8886 NN denotes P21
T2770 8887-8888 -LRB- denotes (
T2771 8897-8902 VBN denotes shown
T2772 8888-8892 NNS denotes data
T2773 8893-8896 RB denotes not
T2774 8902-8903 -RRB- denotes )
T2775 8903-8905 , denotes ,
T2776 8905-8908 DT denotes the
T2777 8916-8919 NN denotes age
T2778 8909-8915 JJS denotes oldest
T2779 8920-8928 VBN denotes examined
T2780 8928-8929 . denotes .
T2781 8929-8930 sentence denotes
T2782 10099-10121 sentence denotes In addition to the com
T2783 10099-10101 IN denotes In
T2784 10102-10103 DT denotes a
T2785 10103-10105 VBN denotes dd
T2786 10105-10106 VBG denotes i
T2787 10106-10108 JJ denotes ti
T2788 10108-10109 JJ denotes o
T2789 10109-10110 NN denotes n
T2790 10111-10112 NN denotes t
T2791 10112-10113 IN denotes o
T2792 10114-10115 NN denotes t
T2793 10115-10116 IN denotes h
T2794 10116-10117 JJ denotes e
T2795 10118-10119 NNS denotes c
T2796 10119-10120 NN denotes o
T2797 10120-10121 IN denotes m
T2798 10121-10125 sentence denotes plet
T2799 10121-10122 NN denotes p
T2800 10122-10123 JJ denotes l
T2801 10123-10124 NN denotes e
T2802 10124-10125 NNS denotes t
T2803 10125-10128 sentence denotes e a
T2804 10125-10126 NN denotes e
T2805 10127-10128 NN denotes a
T2806 10128-10135 sentence denotes bsence
T2807 10128-10130 JJ denotes bs
T2808 10130-10131 NNS denotes e
T2809 10131-10132 CD denotes n
T2810 10132-10134 NNS denotes ce
T2811 10135-10139 sentence denotes of o
T2812 10135-10136 VBZ denotes o
T2813 10136-10137 IN denotes f
T2814 10138-10139 VBN denotes o
T2815 10139-10238 sentence denotes uter segments, Crx-/- retinas exhibited three other notable pathologies in the outer segment layer.
T2816 10169-10178 VBD denotes exhibited
T2817 10139-10143 JJ denotes uter
T2818 10144-10152 NNS denotes segments
T2819 10152-10154 , denotes ,
T2820 10154-10157 NN denotes Crx
T2821 10161-10168 NNS denotes retinas
T2822 10157-10158 SYM denotes -
T2823 10158-10159 HYPH denotes /
T2824 10159-10160 SYM denotes -
T2825 10179-10184 CD denotes three
T2826 10199-10210 NNS denotes pathologies
T2827 10185-10190 JJ denotes other
T2828 10191-10198 JJ denotes notable
T2829 10211-10213 IN denotes in
T2830 10214-10217 DT denotes the
T2831 10232-10237 NN denotes layer
T2832 10218-10223 JJ denotes outer
T2833 10224-10231 NN denotes segment
T2834 10237-10238 . denotes .
T2835 10238-10325 sentence denotes First, an abnormal deposition of matrix of unknown identity was noted (Figure 3A, mx).
T3258 12328-12334 NN denotes Figure
T3259 12335-12337 NN denotes 4F
T3260 12337-12339 , denotes ,
T3261 12341-12342 -RRB- denotes )
T3262 12342-12343 . denotes .
T3263 12343-12528 sentence denotes Serial examination of Crx-/- photoreceptors at P7, P10, P14, and P21 by TEM, demonstrated a distinctive lack of any structure interpretable as orderly stacks of discs or forming discs.
T3264 12344-12350 JJ denotes Serial
T3265 12351-12362 NN denotes examination
T3266 12421-12433 VBD denotes demonstrated
T3267 12363-12365 IN denotes of
T3268 12366-12369 NN denotes Crx
T3269 12373-12387 NNS denotes photoreceptors
T3270 12369-12370 SYM denotes -
T3271 12370-12371 HYPH denotes /
T3272 12371-12372 SYM denotes -
T3273 12388-12390 IN denotes at
T3274 12391-12393 NN denotes P7
T3275 12393-12395 , denotes ,
T3345 14052-14053 sentence denotes y
T3346 14052-14053 JJ denotes y
T3347 14053-14056 sentence denotes , t
T3348 14053-14055 , denotes ,
T3349 14055-14056 JJ denotes t
T3350 14056-14059 sentence denotes he
T3351 14056-14058 VBP denotes he
T3352 14059-14062 sentence denotes mor
T3353 14059-14062 RBR denotes mor
T3354 14062-14066 sentence denotes phol
T3355 14062-14064 NNS denotes ph
T3356 14064-14065 IN denotes o
T3357 14065-14066 NN denotes l
T3358 14066-14068 sentence denotes og
T3359 14066-14067 NN denotes o
T3360 14067-14068 VBG denotes g
T3361 14068-14071 sentence denotes y o
T3362 14068-14069 JJ denotes y
T3363 14070-14071 RB denotes o
T3364 14071-14171 sentence denotes f the malformed Crx-/- photoreceptors was compared to rhodopsin-/- and peripherin-/- photoreceptors.
T3365 14113-14121 VBN denotes compared
T3366 14071-14072 IN denotes f
T3367 14073-14076 DT denotes the
T3368 14094-14108 NNS denotes photoreceptors
T3369 14077-14086 JJ denotes malformed
T3370 14087-14090 NN denotes Crx
T3371 14090-14091 SYM denotes -
T3372 14091-14092 HYPH denotes /
T3373 14092-14093 SYM denotes -
T3374 14109-14112 VBD denotes was
T3375 14122-14124 IN denotes to
T3376 14125-14134 NN denotes rhodopsin
T3377 14156-14170 NNS denotes photoreceptors
T3378 14134-14135 SYM denotes -
T3379 14135-14136 HYPH denotes /
T3380 14136-14137 SYM denotes -
T3381 14138-14141 CC denotes and
T3382 14142-14152 NN denotes peripherin
T3383 14152-14153 SYM denotes -
T3384 14153-14154 HYPH denotes /
T3385 14154-14155 SYM denotes -
T3386 14170-14171 . denotes .
T3387 14171-14315 sentence denotes Rhodopsin and peripherin are two photoreceptor-specific genes whose expression is significantly downregulated in the Crx-/- retinae [10,34,35].
R86 T214 T210 prep of,strain
R87 T215 T214 pobj mice,of
R5 T118 T115 cc and,Synaptogenesis
R6 T119 T120 amod outer,segment
R7 T120 T121 compound segment,formation
R8 T121 T115 conj formation,Synaptogenesis
R9 T122 T116 auxpass are,perturbed
R10 T123 T116 prep in,perturbed
R11 T124 T125 det the,retina
R12 T125 T123 pobj retina,in
R13 T126 T125 amod neural,retina
R14 T127 T125 prep of,retina
R15 T128 T129 compound Crx,mice
R16 T129 T127 pobj mice,of
R17 T130 T129 compound mutant,mice
R18 T135 T136 prep In,are
R19 T137 T138 poss Leber,amaurosis
R20 T138 T135 pobj amaurosis,In
R21 T139 T137 case 's,Leber
R22 T140 T138 amod congenital,amaurosis
R23 T141 T138 punct (,amaurosis
R24 T142 T138 appos LCA,amaurosis
R25 T143 T136 punct ),are
R26 T144 T136 punct ", ",are
R27 T145 T146 amod affected,individuals
R28 T146 T136 nsubj individuals,are
R29 T147 T136 acomp blind,are
R30 T148 T147 punct ", ",blind
R31 T149 T147 cc or,blind
R32 T150 T151 advmod nearly,so
R33 T151 T147 conj so,blind
R34 T152 T136 punct ", ",are
R35 T153 T136 prep from,are
R36 T154 T153 pobj birth,from
R37 T155 T136 punct .,are
R38 T157 T158 det This,onset
R39 T158 T160 nsubj onset,suggests
R40 T159 T158 amod early,onset
R41 T161 T162 amod abnormal,development
R42 T162 T160 dobj development,suggests
R43 T163 T162 prep of,development
R44 T164 T165 det the,retina
R45 T165 T163 pobj retina,of
R46 T166 T165 amod neural,retina
R47 T167 T160 punct .,suggests
R48 T169 T170 nsubjpass Mutations,found
R49 T171 T169 prep in,Mutations
R50 T172 T171 pobj genes,in
R51 T173 T174 dep that,affect
R52 T174 T172 relcl affect,genes
R53 T175 T176 det the,development
R54 T176 T174 dobj development,affect
R55 T177 T176 cc and,development
R56 T178 T177 punct /,and
R57 T179 T177 cc or,and
R58 T180 T176 conj function,development
R59 T181 T176 prep of,development
R60 T182 T183 compound photoreceptor,cells
R61 T183 T181 pobj cells,of
R62 T184 T170 aux have,found
R63 T185 T170 auxpass been,found
R64 T186 T187 aux to,be
R65 T187 T170 xcomp be,found
R66 T188 T187 acomp responsible,be
R67 T189 T170 prep in,found
R68 T190 T191 det some,families
R69 T191 T189 pobj families,in
R70 T192 T170 punct .,found
R71 T194 T195 det These,examples
R72 T195 T196 nsubj examples,include
R73 T197 T196 dobj mutations,include
R74 T198 T197 prep in,mutations
R75 T199 T200 det the,factor
R76 T200 T198 pobj factor,in
R77 T201 T202 compound photoreceptor,transcription
R78 T202 T200 compound transcription,factor
R79 T203 T200 punct ", ",factor
R80 T204 T200 appos Crx,factor
R81 T205 T196 punct .,include
R82 T209 T210 det A,strain
R83 T210 T213 nsubjpass strain,created
R84 T211 T210 nmod Crx,strain
R85 T212 T210 amod mutant,strain
R88 T216 T213 auxpass was,created
R89 T217 T218 aux to,serve
R90 T218 T213 advcl serve,created
R91 T219 T218 prep as,serve
R92 T220 T221 det a,model
R93 T221 T219 pobj model,as
R94 T222 T221 prep for,model
R95 T223 T222 pobj LCA,for
R96 T224 T218 cc and,serve
R97 T225 T226 aux to,provide
R98 T226 T218 conj provide,serve
R99 T227 T228 amod more,insight
R100 T228 T226 dobj insight,provide
R101 T229 T228 prep into,insight
R102 T230 T231 poss Crx,function
R103 T231 T229 pobj function,into
R104 T232 T230 case 's,Crx
R105 T233 T213 punct .,created
R106 T235 T236 prep In,performed
R107 T237 T238 det this,study
R108 T238 T235 pobj study,In
R109 T239 T236 punct ", ",performed
R110 T240 T241 det an,analysis
R111 T241 T236 nsubjpass analysis,performed
R112 T242 T241 amod ultrastructural,analysis
R113 T243 T241 prep of,analysis
R114 T244 T245 det the,retina
R115 T245 T243 pobj retina,of
R116 T246 T245 amod developing,retina
R117 T247 T245 prep in,retina
R118 T248 T249 compound Crx,mice
R119 T249 T247 pobj mice,in
R120 T250 T249 compound mutant,mice
R121 T251 T236 auxpass was,performed
R122 T252 T236 punct .,performed
R123 T254 T255 amod Outer,morphogenesis
R124 T255 T257 nsubjpass morphogenesis,found
R125 T256 T255 compound segment,morphogenesis
R126 T258 T257 auxpass was,found
R127 T259 T260 aux to,blocked
R128 T260 T257 xcomp blocked,found
R129 T261 T260 auxpass be,blocked
R130 T262 T260 prep at,blocked
R131 T263 T264 det the,stage
R132 T264 T262 pobj stage,at
R133 T265 T264 compound elongation,stage
R134 T266 T260 punct ", ",blocked
R135 T267 T260 advcl leading,blocked
R136 T268 T267 prep to,leading
R137 T269 T270 det a,failure
R138 T270 T268 pobj failure,to
R139 T271 T270 prep in,failure
R140 T272 T271 pobj production,in
R141 T273 T272 prep of,production
R142 T274 T275 det the,apparatus
R143 T275 T273 pobj apparatus,of
R144 T276 T275 compound phototransduction,apparatus
R145 T277 T257 punct .,found
R146 T279 T280 advmod Further,demonstrated
R147 T281 T280 punct ", ",demonstrated
R148 T282 T283 nmod Crx,photoreceptors
R150 T284 T282 punct -,Crx
R151 T285 T282 punct /,Crx
R152 T286 T282 punct -,Crx
R153 T287 T288 advmod severely,abnormal
R154 T288 T289 amod abnormal,endings
R155 T289 T280 dobj endings,demonstrated
R156 T290 T289 amod synaptic,endings
R157 T291 T289 prep in,endings
R158 T292 T293 det the,layer
R159 T293 T291 pobj layer,in
R160 T294 T293 amod outer,layer
R161 T295 T293 compound plexiform,layer
R162 T296 T280 punct .,demonstrated
R163 T300 T301 nsubj This,is
R164 T302 T303 det the,report
R165 T303 T301 attr report,is
R166 T304 T303 amod first,report
R167 T305 T303 prep of,report
R168 T306 T307 det a,defect
R169 T307 T305 pobj defect,of
R170 T308 T307 compound synaptogenesis,defect
R171 T309 T307 prep in,defect
R172 T310 T311 det an,model
R173 T311 T309 pobj model,in
R174 T312 T311 compound animal,model
R175 T313 T311 prep for,model
R176 T314 T313 pobj LCA,for
R177 T315 T301 punct .,is
R178 T317 T318 det These,data
R179 T318 T319 nsubj data,confirm
R180 T320 T321 det the,role
R181 T321 T319 dobj role,confirm
R182 T322 T321 amod essential,role
R183 T323 T324 det this,gene
R184 T324 T325 nsubj gene,plays
R185 T325 T321 advcl plays,role
R186 T326 T325 prep in,plays
R187 T327 T328 amod multiple,aspects
R188 T328 T326 pobj aspects,in
R189 T329 T328 prep of,aspects
R190 T330 T331 compound photoreceptor,development
R191 T331 T329 pobj development,of
R192 T332 T319 cc and,confirm
R193 T333 T319 conj extend,confirm
R194 T334 T335 poss our,understanding
R195 T335 T333 dobj understanding,extend
R196 T336 T335 prep of,understanding
R197 T337 T338 det the,pathology
R198 T338 T336 pobj pathology,of
R199 T339 T338 amod basic,pathology
R200 T340 T338 prep of,pathology
R201 T341 T340 pobj LCA,of
R202 T342 T319 punct .,confirm
R203 T115 T116 nsubjpass Synaptogenesis,perturbed
R220 T822 T823 compound Photoreceptor,cells
R221 T823 T824 nsubj cells,play
R222 T825 T826 det a,role
R223 T826 T824 dobj role,play
R224 T827 T826 amod primary,role
R225 T828 T824 prep in,play
R226 T829 T828 pobj vision,in
R227 T830 T824 prep by,play
R228 T831 T830 pcomp capturing,by
R229 T832 T833 compound light,energy
R230 T833 T831 dobj energy,capturing
R231 T834 T831 cc and,capturing
R232 T835 T831 conj converting,capturing
R233 T836 T835 dobj it,converting
R234 T837 T835 prep into,converting
R235 T838 T839 amod neural,stimuli
R236 T839 T837 pobj stimuli,into
R237 T840 T824 punct .,play
R238 T842 T843 det These,neurons
R239 T843 T845 nsubj neurons,are
R240 T844 T843 amod sensory,neurons
R241 T846 T847 det a,element
R242 T847 T845 attr element,are
R243 T848 T847 amod shared,element
R244 T849 T845 prep in,are
R245 T850 T851 det all,organisms
R246 T851 T849 pobj organisms,in
R247 T852 T851 amod capable,organisms
R248 T853 T852 prep of,capable
R249 T854 T853 pcomp sensing,of
R250 T855 T854 dobj light,sensing
R251 T856 T845 punct .,are
R252 T858 T859 prep In,are
R253 T860 T858 pobj humans,In
R254 T861 T859 punct ", ",are
R255 T862 T863 amod genetic,diseases
R256 T863 T859 nsubj diseases,are
R257 T864 T863 prep of,diseases
R258 T865 T866 det the,eye
R259 T866 T864 pobj eye,of
R260 T867 T859 acomp common,are
R261 T868 T859 cc and,are
R262 T869 T870 det the,site
R263 T870 T872 nsubj site,is
R264 T871 T870 amod primary,site
R265 T872 T859 conj is,are
R266 T873 T870 prep of,site
R267 T874 T873 pobj disease,of
R268 T875 T876 advmod most,frequently
R269 T876 T872 advmod frequently,is
R270 T877 T872 attr photoreceptors,is
R271 T878 T879 punct (,see
R272 T879 T872 parataxis see,is
R273 T880 T879 prep for,see
R274 T881 T880 pobj review,for
R275 T882 T879 punct [,see
R276 T883 T879 dobj 1,see
R277 T884 T885 punct -,3
R278 T885 T883 prep 3,1
R279 T886 T879 punct ],see
R280 T887 T879 punct ),see
R281 T888 T859 punct .,are
R282 T890 T891 nsubjpass Photoreceptors,studied
R283 T892 T891 aux have,studied
R284 T893 T891 auxpass been,studied
R285 T894 T891 advmod well,studied
R286 T895 T891 punct ", ",studied
R287 T896 T897 advmod particularly,with
R288 T897 T891 prep with,studied
R289 T898 T897 pobj respect,with
R290 T899 T898 prep to,respect
R291 T900 T901 det the,biochemistry
R292 T901 T899 pobj biochemistry,to
R293 T902 T901 cc and,biochemistry
R294 T903 T901 conj physiology,biochemistry
R295 T904 T901 prep of,biochemistry
R296 T905 T904 pobj phototransduction,of
R297 T906 T891 punct .,studied
R298 T908 T909 nsubj Insight,lagged
R299 T910 T908 prep into,Insight
R300 T911 T912 det the,development
R301 T912 T910 pobj development,into
R302 T913 T912 prep of,development
R303 T914 T915 compound vertebrate,photoreceptors
R304 T915 T913 pobj photoreceptors,of
R305 T916 T909 punct ", ",lagged
R306 T917 T909 advmod however,lagged
R307 T918 T909 punct ", ",lagged
R308 T919 T909 aux has,lagged
R309 T920 T909 prep behind,lagged
R310 T921 T922 poss our,understanding
R311 T922 T920 pobj understanding,behind
R312 T923 T922 prep of,understanding
R313 T924 T923 pobj function,of
R314 T925 T909 punct .,lagged
R315 T927 T928 advmod Only,recently
R316 T928 T929 advmod recently,identified
R317 T930 T929 aux have,identified
R318 T931 T932 det the,mechanisms
R319 T932 T929 nsubjpass mechanisms,identified
R320 T933 T932 amod first,mechanisms
R321 T934 T932 amod molecular,mechanisms
R322 T935 T932 acl regulating,mechanisms
R323 T936 T937 compound photoreceptor,development
R324 T937 T935 dobj development,regulating
R325 T938 T929 auxpass been,identified
R326 T939 T940 punct (,see
R327 T940 T929 parataxis see,identified
R328 T941 T940 prep for,see
R329 T942 T941 pobj review,for
R330 T943 T940 punct ", ",see
R331 T944 T940 punct [,see
R332 T945 T946 nummod 2,4
R333 T946 T940 dobj 4,see
R334 T947 T946 punct ",",4
R335 T948 T940 punct ],see
R336 T949 T940 punct ),see
R337 T950 T929 punct .,identified
R338 T952 T953 nsubj Crx,is
R339 T954 T952 punct (,Crx
R340 T955 T956 compound cone,rod
R341 T956 T958 compound rod,homeobox
R342 T957 T956 punct -,rod
R343 T958 T952 appos homeobox,Crx
R344 T959 T953 punct ),is
R345 T960 T961 det an,gene
R346 T961 T953 attr gene,is
R347 T962 T963 compound otx,family
R348 T963 T965 compound family,homeobox
R349 T964 T963 punct -,family
R350 T965 T961 compound homeobox,gene
R351 T966 T961 acl expressed,gene
R352 T967 T966 advmod predominantly,expressed
R353 T968 T966 prep in,expressed
R354 T969 T968 pobj photoreceptors,in
R355 T970 T966 punct ", ",expressed
R356 T971 T966 prep from,expressed
R357 T972 T971 pcomp early,from
R358 T973 T972 prep in,early
R359 T974 T975 poss their,development
R360 T975 T973 pobj development,in
R361 T976 T971 prep through,from
R362 T977 T976 prep to,through
R363 T978 T979 det the,ages
R364 T979 T977 pobj ages,to
R365 T980 T979 amod adult,ages
R366 T981 T982 punct [,5
R367 T982 T966 parataxis 5,expressed
R368 T983 T984 punct -,7
R369 T984 T982 prep 7,5
R370 T985 T982 punct ],5
R371 T986 T953 punct .,is
R372 T988 T989 compound Crx,expression
R373 T989 T991 nsubj expression,is
R374 T990 T989 compound gene,expression
R375 T992 T993 advmod critically,dependent
R376 T993 T991 acomp dependent,is
R377 T994 T993 prep upon,dependent
R378 T995 T994 pobj Otx2,upon
R379 T996 T995 punct ", ",Otx2
R380 T997 T998 det another,member
R381 T998 T995 appos member,Otx2
R382 T999 T998 prep of,member
R383 T1000 T1001 det the,family
R384 T1001 T999 pobj family,of
R385 T1002 T1001 amod same,family
R386 T1003 T1001 compound homeobox,family
R387 T1004 T1005 dep which,expressed
R388 T1005 T998 relcl expressed,member
R389 T1006 T1005 auxpass is,expressed
R390 T1007 T1005 prep in,expressed
R391 T1008 T1009 amod early,cells
R392 T1009 T1007 pobj cells,in
R393 T1010 T1009 compound photoreceptor,cells
R394 T1011 T1012 punct [,8
R395 T1012 T991 parataxis 8,is
R396 T1013 T1012 punct ],8
R397 T1014 T991 punct .,is
R398 T1016 T1017 prep In,appears
R399 T1018 T1019 compound rod,photoreceptors
R400 T1019 T1016 pobj photoreceptors,In
R401 T1020 T1017 punct ", ",appears
R402 T1021 T1017 nsubj Crx,appears
R403 T1022 T1023 aux to,work
R404 T1023 T1017 xcomp work,appears
R405 T1024 T1023 prep in,work
R406 T1025 T1024 pobj concert,in
R407 T1026 T1025 prep with,concert
R408 T1027 T1026 pobj Nrl,with
R409 T1028 T1027 punct ", ",Nrl
R410 T1029 T1030 det a,protein
R411 T1030 T1027 appos protein,Nrl
R412 T1031 T1032 compound leucine,zipper
R413 T1032 T1030 compound zipper,protein
R414 T1033 T1034 dep that,restricted
R415 T1034 T1030 relcl restricted,protein
R416 T1035 T1034 auxpass is,restricted
R417 T1036 T1034 advmod also,restricted
R418 T1037 T1034 prep in,restricted
R419 T1038 T1039 poss its,expression
R420 T1039 T1037 pobj expression,in
R421 T1040 T1039 prep in,expression
R422 T1041 T1042 det the,retina
R423 T1042 T1040 pobj retina,in
R424 T1043 T1034 prep to,restricted
R425 T1044 T1045 compound rod,photoreceptors
R426 T1045 T1043 pobj photoreceptors,to
R427 T1046 T1047 punct [,9
R428 T1047 T1034 parataxis 9,restricted
R429 T1048 T1047 punct ],9
R430 T1049 T1017 punct .,appears
R431 T1051 T1052 amod Many,genes
R432 T1052 T1056 nsubj genes,have
R433 T1053 T1054 npadvmod photoreceptor,specific
R434 T1054 T1052 amod specific,genes
R435 T1055 T1054 punct -,specific
R436 T1057 T1058 amod putative,elements
R437 T1058 T1056 dobj elements,have
R438 T1059 T1060 npadvmod Crx,binding
R439 T1060 T1058 amod binding,elements
R440 T1061 T1060 punct -,binding
R441 T1062 T1056 prep in,have
R442 T1063 T1064 poss their,regions
R443 T1064 T1062 pobj regions,in
R444 T1065 T1064 amod regulatory,regions
R445 T1066 T1067 punct [,10
R446 T1067 T1056 parataxis 10,have
R447 T1068 T1067 punct ],10
R448 T1069 T1056 punct ", ",have
R449 T1070 T1056 prep including,have
R450 T1071 T1070 pobj rhodopsin,including
R451 T1072 T1073 punct [,11
R452 T1073 T1071 parataxis 11,rhodopsin
R453 T1074 T1073 punct ],11
R454 T1075 T1071 cc and,rhodopsin
R455 T1076 T1071 conj arrestin,rhodopsin
R456 T1077 T1078 punct [,12
R457 T1078 T1076 parataxis 12,arrestin
R458 T1079 T1078 punct ],12
R459 T1080 T1056 punct .,have
R460 T1082 T1083 nsubjpass Mutations,associated
R461 T1084 T1082 prep in,Mutations
R462 T1085 T1084 pobj Crx,in
R463 T1086 T1083 aux have,associated
R464 T1087 T1083 auxpass been,associated
R465 T1088 T1083 prep with,associated
R466 T1089 T1090 amod several,diseases
R467 T1090 T1088 pobj diseases,with
R468 T1091 T1090 amod human,diseases
R469 T1092 T1093 dep that,lead
R470 T1093 T1090 relcl lead,diseases
R471 T1094 T1093 prep to,lead
R472 T1095 T1094 pobj blindness,to
R473 T1096 T1090 punct ", ",diseases
R474 T1097 T1090 prep including,diseases
R475 T1098 T1099 compound cone,rod
R476 T1099 T1101 compound rod,dystrophy
R477 T1100 T1099 punct -,rod
R478 T1101 T1097 pobj dystrophy,including
R479 T1102 T1101 nummod 2,dystrophy
R480 T1103 T1104 punct [,14
R481 T1104 T1101 parataxis 14,dystrophy
R482 T1105 T1104 nummod 6,14
R483 T1106 T1104 punct ",",14
R484 T1107 T1104 nummod 13,14
R485 T1108 T1104 punct ",",14
R486 T1109 T1104 punct ],14
R487 T1110 T1101 punct ", ",dystrophy
R488 T1111 T1112 compound retinitis,pigmentosa
R489 T1112 T1101 conj pigmentosa,dystrophy
R490 T1113 T1114 punct [,14
R491 T1114 T1112 parataxis 14,pigmentosa
R492 T1115 T1114 punct ],14
R493 T1116 T1112 punct ", ",pigmentosa
R494 T1117 T1112 cc and,pigmentosa
R495 T1118 T1112 conj LCA,pigmentosa
R496 T1119 T1120 punct [,14
R497 T1120 T1118 parataxis 14,LCA
R498 T1121 T1122 punct -,16
R499 T1122 T1120 prep 16,14
R500 T1123 T1120 punct ],14
R501 T1124 T1083 punct .,associated
R502 T1126 T1127 prep Based,hypothesized
R503 T1128 T1126 prep on,Based
R504 T1129 T1130 det these,data
R505 T1130 T1128 pobj data,on
R506 T1131 T1127 punct ", ",hypothesized
R507 T1132 T1127 nsubjpass Crx,hypothesized
R508 T1133 T1127 auxpass was,hypothesized
R509 T1134 T1135 aux to,play
R510 T1135 T1127 xcomp play,hypothesized
R511 T1136 T1137 det a,role
R512 T1137 T1135 dobj role,play
R513 T1138 T1137 amod critical,role
R514 T1139 T1135 prep in,play
R515 T1140 T1141 det the,differentiation
R516 T1141 T1139 pobj differentiation,in
R517 T1142 T1141 cc and,differentiation
R518 T1143 T1141 conj maintainance,differentiation
R519 T1144 T1141 prep of,differentiation
R520 T1145 T1146 compound photoreceptor,cells
R521 T1146 T1144 pobj cells,of
R522 T1147 T1148 punct [,7
R523 T1148 T1135 parataxis 7,play
R524 T1149 T1148 nummod 5,7
R525 T1150 T1148 punct ",",7
R526 T1151 T1148 punct ],7
R527 T1152 T1127 punct .,hypothesized
R528 T1154 T1155 nsubj LCA,is
R529 T1156 T1157 det the,disease
R530 T1157 T1155 attr disease,is
R531 T1158 T1159 advmod most,severe
R532 T1159 T1157 amod severe,disease
R533 T1160 T1157 amod genetic,disease
R534 T1161 T1157 prep of,disease
R535 T1162 T1161 pobj photoreceptors,of
R536 T1163 T1164 punct (,see
R537 T1164 T1155 parataxis see,is
R538 T1165 T1164 punct [,see
R539 T1166 T1164 dobj 17,see
R540 T1167 T1164 punct ],see
R541 T1168 T1164 punct ", ",see
R542 T1169 T1164 prep for,see
R543 T1170 T1171 amod recent,review
R544 T1171 T1169 pobj review,for
R545 T1172 T1164 punct ),see
R546 T1173 T1155 punct .,is
R547 T1175 T1176 amod Affected,infants
R548 T1176 T1177 nsubj infants,exhibit
R549 T1178 T1179 det a,absence
R550 T1179 T1177 dobj absence,exhibit
R551 T1180 T1179 amod complete,absence
R552 T1181 T1180 cc or,complete
R553 T1182 T1183 advmod near,complete
R554 T1183 T1180 conj complete,complete
R555 T1184 T1179 prep of,absence
R556 T1185 T1184 pobj vision,of
R557 T1186 T1177 prep from,exhibit
R558 T1187 T1186 pobj birth,from
R559 T1188 T1177 punct .,exhibit
R560 T1190 T1191 nsubjpass Mutations,associated
R561 T1192 T1190 prep in,Mutations
R562 T1193 T1194 npadvmod retinal,specific
R563 T1194 T1195 amod specific,genes
R564 T1195 T1192 pobj genes,in
R565 T1196 T1195 punct ", ",genes
R566 T1197 T1198 amod such,as
R567 T1198 T1195 prep as,genes
R568 T1199 T1198 pobj Crx,as
R569 T1200 T1191 punct ", ",associated
R570 T1201 T1191 aux have,associated
R571 T1202 T1191 auxpass been,associated
R572 T1203 T1191 prep with,associated
R573 T1204 T1203 pobj LCA,with
R574 T1205 T1206 punct [,15
R575 T1206 T1204 parataxis 15,LCA
R576 T1207 T1206 nummod 14,15
R577 T1208 T1206 punct ",",15
R578 T1209 T1206 punct ],15
R579 T1210 T1204 punct ", ",LCA
R580 T1211 T1212 advmod as,as
R581 T1212 T1204 cc as,LCA
R582 T1213 T1212 advmod well,as
R583 T1214 T1204 conj GUCY2D,LCA
R584 T1215 T1216 punct [,18
R585 T1216 T1214 parataxis 18,GUCY2D
R586 T1217 T1216 punct ],18
R587 T1218 T1214 punct ", ",GUCY2D
R588 T1219 T1214 conj RPE65,GUCY2D
R589 T1220 T1221 punct [,19
R590 T1221 T1219 parataxis 19,RPE65
R591 T1222 T1221 punct ],19
R592 T1223 T1219 punct ", ",RPE65
R593 T1224 T1219 conj AIPL,RPE65
R594 T1225 T1224 punct -,AIPL
R595 T1226 T1224 nummod 1,AIPL
R596 T1227 T1228 punct [,20
R597 T1228 T1224 parataxis 20,AIPL
R598 T1229 T1228 punct ],20
R599 T1230 T1224 punct ", ",AIPL
R600 T1231 T1224 conj CRB,AIPL
R601 T1232 T1231 punct -,CRB
R602 T1233 T1231 nummod 1,CRB
R603 T1234 T1235 punct [,21
R604 T1235 T1231 parataxis 21,CRB
R605 T1236 T1235 punct ],21
R606 T1237 T1231 punct ", ",CRB
R607 T1238 T1231 cc and,CRB
R608 T1239 T1231 conj RPGRIP,CRB
R609 T1240 T1239 punct -,RPGRIP
R610 T1241 T1239 nummod 1,RPGRIP
R611 T1242 T1243 punct [,22
R612 T1243 T1239 parataxis 22,RPGRIP
R613 T1244 T1243 punct ],22
R614 T1245 T1191 punct .,associated
R615 T1247 T1248 expl There,be
R616 T1249 T1248 advmod also,be
R617 T1250 T1248 aux may,be
R618 T1251 T1252 advmod as,three
R619 T1252 T1255 nummod three,loci
R620 T1253 T1252 amod many,three
R621 T1254 T1252 quantmod as,three
R622 T1255 T1248 attr loci,be
R623 T1256 T1255 amod additional,loci
R624 T1257 T1258 advmod genetically,linked
R625 T1258 T1255 amod linked,loci
R626 T1259 T1260 advmod where,identified
R627 T1260 T1255 relcl identified,loci
R628 T1261 T1260 nsubjpass genes,identified
R629 T1262 T1260 aux have,identified
R630 T1263 T1260 neg not,identified
R631 T1264 T1260 auxpass been,identified
R632 T1265 T1266 punct [,23
R633 T1266 T1255 parataxis 23,loci
R634 T1267 T1266 punct ],23
R635 T1268 T1248 punct .,be
R636 T1270 T1271 compound Crx,mutations
R637 T1271 T1272 nsubj mutations,are
R638 T1273 T1271 prep in,mutations
R639 T1274 T1273 pobj LCA,in
R640 T1275 T1272 acomp varied,are
R641 T1276 T1272 punct ", ",are
R642 T1277 T1272 cc and,are
R643 T1278 T1272 conj include,are
R644 T1279 T1280 det a,mutation
R645 T1280 T1278 dobj mutation,include
R646 T1281 T1280 amod putative,mutation
R647 T1282 T1280 amod dominant,mutation
R648 T1283 T1284 dep that,proposed
R649 T1284 T1280 relcl proposed,mutation
R650 T1285 T1284 auxpass is,proposed
R651 T1286 T1287 aux to,encode
R652 T1287 T1284 xcomp encode,proposed
R653 T1288 T1289 det a,form
R654 T1289 T1287 dobj form,encode
R655 T1290 T1291 amod dominant,negative
R656 T1291 T1289 nmod negative,form
R657 T1292 T1291 punct -,negative
R658 T1293 T1289 prep of,form
R659 T1294 T1293 pobj Crx,of
R660 T1295 T1296 punct [,15
R661 T1296 T1287 parataxis 15,encode
R662 T1297 T1296 nummod 14,15
R663 T1298 T1296 punct ",",15
R664 T1299 T1296 punct ],15
R665 T1300 T1272 punct .,are
R666 T1302 T1303 amod Recessive,mutations
R667 T1303 T1304 nsubjpass mutations,reported
R668 T1305 T1304 advmod also,reported
R669 T1306 T1304 aux have,reported
R670 T1307 T1304 auxpass been,reported
R671 T1308 T1304 cc and,reported
R672 T1309 T1310 advmod at,one
R673 T1310 T1312 nummod one,allele
R674 T1311 T1310 advmod least,one
R675 T1312 T1313 nsubj allele,encodes
R676 T1313 T1304 conj encodes,reported
R677 T1314 T1315 det a,protein
R678 T1315 T1313 dobj protein,encodes
R679 T1316 T1315 prep with,protein
R680 T1317 T1318 amod decreased,activity
R681 T1318 T1316 pobj activity,with
R682 T1319 T1318 nmod DNA,activity
R683 T1320 T1319 punct -,DNA
R684 T1321 T1319 amod binding,DNA
R685 T1322 T1323 punct [,16
R686 T1323 T1313 parataxis 16,encodes
R687 T1324 T1323 punct ],16
R688 T1325 T1313 punct .,encodes
R689 T1327 T1328 amod Histopathological,studies
R690 T1328 T1331 nsubj studies,enable
R691 T1329 T1327 cc and,Histopathological
R692 T1330 T1327 conj ultrastructural,Histopathological
R693 T1332 T1328 prep of,studies
R694 T1333 T1332 pobj LCA,of
R695 T1334 T1331 aux should,enable
R696 T1335 T1336 det a,understanding
R697 T1336 T1331 dobj understanding,enable
R698 T1337 T1336 amod better,understanding
R699 T1338 T1336 prep of,understanding
R700 T1339 T1340 det the,process
R701 T1340 T1338 pobj process,of
R702 T1341 T1340 compound disease,process
R703 T1342 T1336 punct ", ",understanding
R704 T1343 T1336 cc and,understanding
R705 T1344 T1345 det the,design
R706 T1345 T1336 conj design,understanding
R707 T1346 T1345 prep of,design
R708 T1347 T1348 amod suitable,therapies
R709 T1348 T1346 pobj therapies,of
R710 T1349 T1331 punct .,enable
R711 T1351 T1352 amod Few,studies
R712 T1352 T1354 nsubj studies,exist
R713 T1353 T1352 amod such,studies
R714 T1355 T1354 prep for,exist
R715 T1356 T1357 amod human,LCA
R716 T1357 T1355 pobj LCA,for
R717 T1358 T1359 punct (,reviewed
R718 T1359 T1354 parataxis reviewed,exist
R719 T1360 T1359 prep in,reviewed
R720 T1361 T1360 punct [,in
R721 T1362 T1360 pobj 17,in
R722 T1363 T1359 punct ],reviewed
R723 T1364 T1359 punct ),reviewed
R724 T1365 T1354 cc and,exist
R725 T1366 T1367 det the,majority
R726 T1367 T1368 nsubj majority,examine
R727 T1368 T1354 conj examine,exist
R728 T1369 T1367 prep of,majority
R729 T1370 T1371 amod such,studies
R730 T1371 T1369 pobj studies,of
R731 T1372 T1373 det the,globes
R732 T1373 T1368 dobj globes,examine
R733 T1374 T1373 prep of,globes
R734 T1375 T1374 pobj adults,of
R735 T1376 T1375 prep with,adults
R736 T1377 T1376 pobj LCA,with
R737 T1378 T1368 punct ", ",examine
R738 T1379 T1380 mark after,undergone
R739 T1380 T1368 advcl undergone,examine
R740 T1381 T1382 det the,tissue
R741 T1382 T1380 nsubj tissue,undergone
R742 T1383 T1380 aux has,undergone
R743 T1384 T1385 amod secondary,changes
R744 T1385 T1380 dobj changes,undergone
R745 T1386 T1368 punct .,examine
R746 T1388 T1389 advmod Only,study
R747 T1389 T1392 nsubj study,exists
R748 T1390 T1389 det a,study
R749 T1391 T1389 amod single,study
R750 T1393 T1394 advmod where,examined
R751 T1394 T1392 ccomp examined,exists
R752 T1395 T1396 det the,eye
R753 T1396 T1394 nsubjpass eye,examined
R754 T1397 T1396 amod developing,eye
R755 T1398 T1396 prep of,eye
R756 T1399 T1400 det an,infant
R757 T1400 T1398 pobj infant,of
R758 T1401 T1394 auxpass was,examined
R759 T1402 T1403 punct [,24
R760 T1403 T1394 parataxis 24,examined
R761 T1404 T1403 punct ],24
R762 T1405 T1392 punct .,exists
R763 T1407 T1408 compound Animal,models
R764 T1408 T1409 nsubjpass models,reported
R765 T1410 T1408 prep for,models
R766 T1411 T1410 pobj LCA,for
R767 T1412 T1409 aux have,reported
R768 T1413 T1409 advmod recently,reported
R769 T1414 T1409 auxpass been,reported
R770 T1415 T1409 cc and,reported
R771 T1416 T1417 aux have,served
R772 T1417 T1409 conj served,reported
R773 T1418 T1417 advmod already,served
R774 T1419 T1420 aux to,broaden
R775 T1420 T1417 xcomp broaden,served
R776 T1421 T1422 poss our,understanding
R777 T1422 T1420 dobj understanding,broaden
R778 T1423 T1422 prep of,understanding
R779 T1424 T1425 det the,pathology
R780 T1425 T1423 pobj pathology,of
R781 T1426 T1425 prep of,pathology
R782 T1427 T1428 det this,disease
R783 T1428 T1426 pobj disease,of
R784 T1429 T1430 punct [,25
R785 T1430 T1420 parataxis 25,broaden
R786 T1431 T1432 punct -,28
R787 T1432 T1430 prep 28,25
R788 T1433 T1430 punct ],25
R789 T1434 T1409 punct .,reported
R790 T1436 T1437 mark Since,is
R791 T1437 T1439 advcl is,are
R792 T1438 T1437 nsubj LCA,is
R793 T1440 T1441 det a,disorder
R794 T1441 T1437 attr disorder,is
R795 T1442 T1443 advmod clinically,heterogeneous
R796 T1443 T1441 amod heterogeneous,disorder
R797 T1444 T1442 cc and,clinically
R798 T1445 T1442 conj genetically,clinically
R799 T1446 T1439 punct ", ",are
R800 T1447 T1448 amod additional,models
R801 T1448 T1439 nsubj models,are
R802 T1449 T1448 compound mouse,models
R803 T1450 T1439 prep in,are
R804 T1451 T1450 pobj order,in
R805 T1452 T1453 aux to,allow
R806 T1453 T1439 advcl allow,are
R807 T1454 T1455 det a,understanding
R808 T1455 T1453 dobj understanding,allow
R809 T1456 T1455 amod full,understanding
R810 T1457 T1455 prep of,understanding
R811 T1458 T1459 det the,ways
R812 T1459 T1457 pobj ways,of
R813 T1460 T1459 amod many,ways
R814 T1461 T1462 prep in,go
R815 T1462 T1459 relcl go,ways
R816 T1463 T1461 pobj which,in
R817 T1464 T1465 compound photoreceptor,development
R818 T1465 T1462 nsubj development,go
R819 T1466 T1462 aux can,go
R820 T1483 T1471 nsubj cells,serve
R821 T1467 T1462 advcl awry,go
R822 T1484 T1471 prep as,serve
R823 T1468 T1439 punct .,are
R824 T1485 T1486 det an,model
R825 T1486 T1484 pobj model,as
R826 T1470 T1471 prep In,serve
R827 T1487 T1486 amod excellent,model
R828 T1488 T1486 prep for,model
R829 T1489 T1488 pobj studies,for
R830 T1490 T1489 prep in,studies
R831 T1491 T1492 amod neuronal,differentiation
R832 T1492 T1490 pobj differentiation,in
R833 T1493 T1471 punct .,serve
R834 T1472 T1470 pobj addition,In
R835 T1495 T1496 compound Photoreceptor,cells
R836 T1496 T1497 nsubj cells,are
R837 T1473 T1472 prep to,addition
R838 T1498 T1499 advmod highly,polarized
R839 T1499 T1497 acomp polarized,are
R840 T1474 T1475 poss their,importance
R841 T1500 T1497 punct .,are
R842 T1475 T1473 pobj importance,to
R843 T1502 T1503 prep At,have
R844 T1504 T1505 poss their,apex
R845 T1476 T1475 prep as,importance
R846 T1505 T1502 pobj apex,At
R847 T1506 T1503 punct ", ",have
R848 T1477 T1478 det a,locus
R849 T1507 T1508 det these,neurons
R850 T1508 T1503 nsubj neurons,have
R851 T1509 T1510 det a,segment
R852 T1478 T1476 pobj locus,as
R853 T1510 T1503 dobj segment,have
R854 T1511 T1510 amod membranous,segment
R855 T1479 T1478 prep of,locus
R856 T1512 T1510 amod outer,segment
R857 T1480 T1479 pobj disease,of
R858 T1481 T1471 punct ", ",serve
R859 T1513 T1510 punct ", ",segment
R860 T1514 T1515 dep which,contains
R861 T1515 T1510 relcl contains,segment
R862 T1482 T1483 compound photoreceptor,cells
R863 T1516 T1515 dobj proteins,contains
R864 T1589 T1590 nmod rod,dendrites
R865 T1517 T1516 acl involved,proteins
R866 T1518 T1517 prep in,involved
R867 T1519 T1520 det the,cascade
R868 T1520 T1518 pobj cascade,in
R869 T1521 T1520 compound phototransduction,cascade
R870 T1590 T1588 pobj dendrites,with
R871 T1522 T1503 punct .,have
R872 T1591 T1590 amod bipolar,dendrites
R873 T1524 T1525 nmod Loss,mutations
R874 T1525 T1528 nsubj mutations,result
R875 T1592 T1590 cc and,dendrites
R876 T1526 T1524 prep of,Loss
R877 T1527 T1526 pobj function,of
R878 T1593 T1594 amod axonal,endings
R879 T1529 T1525 prep in,mutations
R880 T1530 T1529 pobj rhodopsin,in
R881 T1531 T1532 punct [,29
R882 T1532 T1530 parataxis 29,rhodopsin
R883 T1533 T1532 punct ],29
R884 T1534 T1530 punct ", ",rhodopsin
R885 T1594 T1590 conj endings,dendrites
R886 T1535 T1530 cc or,rhodopsin
R887 T1536 T1537 det the,protein
R888 T1537 T1530 conj protein,rhodopsin
R889 T1538 T1537 amod structural,protein
R890 T1595 T1594 prep of,endings
R891 T1539 T1537 punct ", ",protein
R892 T1540 T1537 appos peripherin,protein
R893 T1596 T1597 amod horizontal,cells
R894 T1541 T1542 punct [,30
R895 T1542 T1540 parataxis 30,peripherin
R896 T1597 T1595 pobj cells,of
R897 T1543 T1542 punct ],30
R898 T1544 T1528 punct ", ",result
R899 T1545 T1528 prep in,result
R900 T1598 T1584 punct .,establish
R901 T1546 T1547 det an,inability
R902 T1547 T1545 pobj inability,in
R903 T1548 T1549 aux to,form
R904 T1600 T1601 det This,synapse
R905 T1549 T1547 acl form,inability
R906 T1550 T1551 amod outer,segments
R907 T1551 T1549 dobj segments,form
R908 T1552 T1528 punct .,result
R909 T1601 T1602 nsubjpass synapse,characterized
R910 T1554 T1555 prep At,terminate
R911 T1556 T1557 det the,extremity
R912 T1603 T1602 auxpass is,characterized
R913 T1557 T1554 pobj extremity,At
R914 T1558 T1557 amod other,extremity
R915 T1559 T1555 punct ", ",terminate
R916 T1604 T1602 agent by,characterized
R917 T1560 T1555 nsubj photoreceptors,terminate
R918 T1561 T1555 prep with,terminate
R919 T1562 T1563 amod synaptic,endings
R920 T1563 T1561 pobj endings,with
R921 T1605 T1606 det the,presence
R922 T1564 T1565 dep that,make
R923 T1565 T1563 relcl make,endings
R924 T1566 T1565 dobj contact,make
R926 T1567 T1565 prep with,make
R927 T1568 T1569 det the,processes
R928 T1569 T1567 pobj processes,with
R929 T1607 T1606 prep of,presence
R930 T1570 T1569 prep of,processes
R931 T1571 T1572 amod horizontal,cells
R932 T1572 T1570 pobj cells,of
R933 T1573 T1571 cc and,horizontal
R934 T1574 T1571 conj bipolar,horizontal
R935 T1575 T1576 punct [,32
R936 T1608 T1609 det a,ribbon
R937 T1576 T1565 parataxis 32,make
R938 T1577 T1576 nummod 31,32
R939 T1578 T1576 punct ",",32
R940 T1579 T1576 punct ],32
R941 T1609 T1607 pobj ribbon,of
R942 T1580 T1555 punct .,terminate
R943 T1582 T1583 compound Rod,spherules
R944 T1610 T1606 prep in,presence
R945 T1583 T1584 nsubj spherules,establish
R946 T1611 T1612 det the,cytoplasm
R947 T1585 T1586 det an,synapse
R948 T1586 T1584 dobj synapse,establish
R949 T1587 T1586 amod invaginating,synapse
R950 T1588 T1586 prep with,synapse
R951 T1612 T1610 pobj cytoplasm,in
R952 T1613 T1612 amod presynaptic,cytoplasm
R953 T1614 T1602 punct .,characterized
R954 T1616 T1617 compound Cone,pedicles
R955 T1695 T1688 dobj examination,extended
R956 T1696 T1695 prep of,examination
R957 T1617 T1618 nsubj pedicles,make
R958 T1697 T1698 amod retinal,pathology
R959 T1698 T1696 pobj pathology,of
R960 T1619 T1620 amod invaginating,synapses
R961 T1699 T1688 prep to,extended
R962 T1700 T1701 det the,level
R963 T1701 T1699 pobj level,to
R964 T1702 T1701 amod ultrastructural,level
R965 T1620 T1618 dobj synapses,make
R966 T1703 T1688 punct .,extended
R967 T1621 T1618 prep with,make
R968 T1705 T1706 amod Certain,features
R969 T1706 T1707 nsubjpass features,detected
R970 T1622 T1623 det the,dendrites
R971 T1708 T1706 prep of,features
R972 T1709 T1710 amod neuronal,differentiation
R973 T1623 T1621 pobj dendrites,with
R974 T1710 T1708 pobj differentiation,of
R975 T1711 T1706 punct ", ",features
R976 T1624 T1623 prep of,dendrites
R977 T1712 T1713 amod such,as
R978 T1713 T1706 prep as,features
R979 T1714 T1715 compound synapse,formation
R980 T1625 T1626 nmod on,cells
R981 T1715 T1713 pobj formation,as
R982 T1716 T1707 punct ", ",detected
R983 T1717 T1707 aux can,detected
R984 T1626 T1624 pobj cells,of
R985 T1718 T1707 auxpass be,detected
R986 T1719 T1707 advmod definitively,detected
R987 T1720 T1707 prep at,detected
R988 T1721 T1722 det this,level
R989 T1722 T1720 pobj level,at
R990 T1723 T1722 prep of,level
R991 T1627 T1625 punct -,on
R992 T1724 T1723 pobj analysis,of
R993 T1725 T1707 punct .,detected
R994 T1628 T1625 pobj cone,on
R995 T1727 T1728 prep With,analyzed
R996 T1729 T1730 det the,hope
R997 T1629 T1626 amod bipolar,cells
R998 T1730 T1727 pobj hope,With
R999 T1731 T1730 prep of,hope
R1000 T1630 T1618 cc and,make
R1001 T1732 T1731 pcomp understanding,of
R1002 T1733 T1734 det the,neuropathology
R1003 T1734 T1732 dobj neuropathology,understanding
R1004 T1735 T1734 prep of,neuropathology
R1005 T1631 T1632 amod horizontal,cells
R1006 T1736 T1735 pobj LCA,of
R1007 T1737 T1732 prep in,understanding
R1008 T1738 T1739 amod greater,detail
R1009 T1632 T1618 conj cells,make
R1010 T1739 T1737 pobj detail,in
R1011 T1740 T1728 punct ", ",analyzed
R1012 T1741 T1728 nsubj we,analyzed
R1013 T1633 T1632 cc and,cells
R1014 T1742 T1728 aux have,analyzed
R1015 T1743 T1744 det the,differentiation
R1016 T1634 T1635 amod basal,junctions
R1017 T1744 T1728 dobj differentiation,analyzed
R1018 T1745 T1744 prep of,differentiation
R1019 T1746 T1747 det the,retina
R1020 T1635 T1632 conj junctions,cells
R1021 T1747 T1745 pobj retina,of
R1022 T1748 T1747 amod outer,retina
R1023 T1749 T1744 prep in,differentiation
R1024 T1636 T1632 prep with,cells
R1025 T1750 T1751 nmod Crx,mice
R1026 T1751 T1749 pobj mice,in
R1027 T1752 T1750 punct -,Crx
R1028 T1637 T1638 det the,dendrites
R1029 T1753 T1750 punct /,Crx
R1030 T1754 T1750 punct -,Crx
R1031 T1755 T1728 prep at,analyzed
R1032 T1638 T1636 pobj dendrites,with
R1033 T1756 T1757 det the,level
R1034 T1757 T1755 pobj level,at
R1035 T1639 T1638 prep of,dendrites
R1036 T1758 T1757 amod ultrastructural,level
R1037 T1759 T1728 punct .,analyzed
R1038 T1761 T1762 det These,retinas
R1039 T1762 T1763 nsubj retinas,exhibit
R1040 T1764 T1765 amod several,defects
R1041 T1640 T1641 nmod off,cells
R1042 T1765 T1763 dobj defects,exhibit
R1043 T1766 T1765 amod prominent,defects
R1044 T1767 T1763 punct .,exhibit
R1045 T1641 T1639 pobj cells,of
R1046 T1769 T1770 nmod Crx,photoreceptors
R1047 T1770 T1774 nsubj photoreceptors,demonstrate
R1048 T1642 T1640 punct -,off
R1049 T1771 T1769 punct -,Crx
R1050 T1772 T1769 punct /,Crx
R1051 T1643 T1640 pobj cone,off
R1052 T1773 T1769 punct -,Crx
R1053 T1775 T1776 det a,block
R1054 T1644 T1641 amod bipolar,cells
R1055 T1776 T1774 dobj block,demonstrate
R1056 T1777 T1776 amod complete,block
R1057 T1778 T1776 prep in,block
R1058 T1645 T1618 punct .,make
R1059 T1779 T1780 amod outer,segment
R1060 T1647 T1648 det The,factors
R1061 T1780 T1781 compound segment,formation
R1062 T1648 T1649 nsubj factors,are
R1063 T1781 T1778 pobj formation,in
R1064 T1782 T1774 prep at,demonstrate
R1065 T1650 T1648 acl regulating,factors
R1066 T1783 T1784 det the,stage
R1067 T1784 T1782 pobj stage,at
R1068 T1785 T1784 compound elongation,stage
R1069 T1786 T1774 punct .,demonstrate
R1070 T1651 T1652 det the,formation
R1071 T1788 T1789 advmod Further,exhibit
R1072 T1652 T1650 dobj formation,regulating
R1073 T1790 T1789 punct ", ",exhibit
R1074 T1653 T1652 prep of,formation
R1075 T1791 T1792 det these,cells
R1076 T1792 T1789 nsubj cells,exhibit
R1077 T1793 T1794 amod abnormal,morphology
R1078 T1794 T1789 dobj morphology,exhibit
R1079 T1654 T1655 det the,synapses
R1080 T1795 T1794 amod synaptic,morphology
R1081 T1655 T1653 pobj synapses,of
R1082 T1796 T1789 punct ", ",exhibit
R1083 T1797 T1798 advmod thereby,broadening
R1084 T1798 T1789 advcl broadening,exhibit
R1085 T1656 T1655 compound photoreceptor,synapses
R1086 T1799 T1800 det the,function
R1087 T1800 T1798 dobj function,broadening
R1088 T1657 T1658 advmod completely,unknown
R1089 T1658 T1649 acomp unknown,are
R1090 T1801 T1800 prep of,function
R1091 T1802 T1801 pobj Crx,of
R1092 T1803 T1798 prep to,broadening
R1093 T1804 T1805 compound photoreceptor,synaptogenesis
R1094 T1805 T1803 pobj synaptogenesis,to
R1095 T1659 T1649 punct .,are
R1096 T1806 T1789 punct .,exhibit
R1097 T1808 T1809 nsubj This,represents
R1098 T1661 T1662 advmod At,one
R1099 T1810 T1811 det the,report
R1100 T1811 T1809 dobj report,represents
R1101 T1662 T1664 nummod one,protein
R1102 T1812 T1811 amod first,report
R1103 T1813 T1814 advmod strongly,implicating
R1104 T1814 T1811 acl implicating,report
R1105 T1663 T1662 advmod least,one
R1106 T1664 T1667 nsubj protein,contains
R1107 T1815 T1816 det the,process
R1108 T1816 T1814 dobj process,implicating
R1109 T1665 T1664 nmod photoreceptor,protein
R1110 T1817 T1816 prep of,process
R1111 T1818 T1819 compound synapse,formation
R1112 T1819 T1817 pobj formation,of
R1113 T1666 T1664 amod synaptic,protein
R1114 T1820 T1814 prep in,implicating
R1115 T1821 T1820 pobj LCA,in
R1116 T1822 T1809 punct .,represents
R1117 T1668 T1664 punct ", ",protein
R1118 T1669 T1664 appos HRG4,protein
R1119 T1670 T1667 punct ", ",contains
R1120 T1671 T1672 det a,sequence
R1121 T1672 T1667 dobj sequence,contains
R1122 T1673 T1672 amod potential,sequence
R1123 T1674 T1672 compound Crx,sequence
R1124 T1675 T1672 compound target,sequence
R1125 T1676 T1667 prep in,contains
R1126 T1677 T1678 poss its,sequence
R1127 T1678 T1676 pobj sequence,in
R1128 T1679 T1678 amod transcriptional,sequence
R1129 T1680 T1678 amod regulatory,sequence
R1130 T1681 T1682 punct [,33
R1131 T1682 T1667 parataxis 33,contains
R1132 T1683 T1682 punct ],33
R1133 T1684 T1667 punct .,contains
R1134 T1686 T1687 amod Few,studies
R1135 T1687 T1688 nsubj studies,extended
R1136 T1689 T1687 prep of,studies
R1137 T1690 T1691 compound LCA,models
R1138 T1691 T1689 pobj models,of
R1139 T1692 T1691 compound animal,models
R1140 T1693 T1688 aux have,extended
R1141 T1694 T1695 poss their,examination
R1144 T2359 T2360 amod Multiple,pathologies
R1145 T2361 T2360 prep in,pathologies
R1146 T2362 T2363 det the,layer
R1147 T2363 T2361 pobj layer,in
R1148 T2364 T2365 amod outer,segment
R1149 T2365 T2363 compound segment,layer
R1150 T2366 T2360 prep in,pathologies
R1151 T2367 T2368 nmod Crx,mice
R1152 T2368 T2366 pobj mice,in
R1153 T2369 T2367 punct -,Crx
R1154 T2370 T2367 punct /,Crx
R1155 T2371 T2367 punct -,Crx
R1156 T2373 T2374 det A,protocol
R1157 T2374 T2379 nsubjpass protocol,used
R1158 T2375 T2374 amod standard,protocol
R1159 T2376 T2374 amod knock,protocol
R1160 T2377 T2376 punct -,knock
R1161 T2378 T2376 prt out,knock
R1162 T2380 T2379 auxpass was,used
R1163 T2381 T2382 aux to,generate
R1164 T2382 T2379 advcl generate,used
R1165 T2383 T2382 dobj mice,generate
R1166 T2384 T2385 prep in,targeted
R1167 T2385 T2383 relcl targeted,mice
R1168 T2386 T2384 pobj which,in
R1169 T2387 T2388 det the,homeodomain
R1170 T2388 T2385 nsubjpass homeodomain,targeted
R1171 T2389 T2388 prep of,homeodomain
R1172 T2390 T2389 pobj Crx,of
R1173 T2391 T2390 punct -,Crx
R1174 T2392 T2390 punct /,Crx
R1175 T2393 T2390 punct -,Crx
R1176 T2394 T2385 auxpass was,targeted
R1177 T2395 T2385 cc and,targeted
R1178 T2396 T2385 conj deleted,targeted
R1179 T2397 T2379 punct .,used
R1180 T2399 T2400 nsubjpass Generation,reported
R1181 T2401 T2399 prep of,Generation
R1182 T2402 T2403 det these,mice
R1183 T2403 T2401 pobj mice,of
R1184 T2404 T2403 nmod Crx,mice
R1185 T2405 T2404 punct -,Crx
R1186 T2406 T2404 punct /,Crx
R1187 T2407 T2404 punct -,Crx
R1188 T2408 T2400 aux has,reported
R1189 T2409 T2400 auxpass been,reported
R1190 T2410 T2400 advmod elsewhere,reported
R1191 T2411 T2412 punct [,34
R1192 T2412 T2400 parataxis 34,reported
R1193 T2413 T2412 punct ],34
R1194 T2414 T2400 punct .,reported
R1195 T2416 T2417 prep In,examined
R1196 T2418 T2419 det this,study
R1197 T2419 T2416 pobj study,In
R1198 T2420 T2417 punct ", ",examined
R1199 T2421 T2417 prep in,examined
R1200 T2422 T2421 pobj order,in
R1201 T2423 T2424 aux to,characterize
R1202 T2424 T2422 acl characterize,order
R1203 T2425 T2424 advmod further,characterize
R1204 T2426 T2427 det the,role
R1205 T2427 T2424 dobj role,characterize
R1206 T2428 T2427 prep of,role
R1207 T2429 T2428 pobj Crx,of
R1208 T2430 T2427 prep in,role
R1209 T2431 T2432 compound photoreceptor,morphogenesis
R1210 T2432 T2430 pobj morphogenesis,in
R1211 T2433 T2417 punct ", ",examined
R1212 T2434 T2435 det the,retinae
R1213 T2435 T2417 nsubjpass retinae,examined
R1214 T2436 T2435 amod outer,retinae
R1215 T2437 T2435 prep from,retinae
R1216 T2438 T2439 nmod Crx,mice
R1217 T2439 T2437 pobj mice,from
R1218 T2440 T2438 punct -,Crx
R1219 T2441 T2438 punct /,Crx
R1220 T2442 T2438 punct -,Crx
R1221 T2443 T2417 auxpass were,examined
R1222 T2444 T2417 advcl using,examined
R1223 T2445 T2446 compound transmission,microscopy
R1224 T2446 T2444 dobj microscopy,using
R1225 T2447 T2446 compound electron,microscopy
R1226 T2448 T2417 punct .,examined
R1227 T2450 T2451 prep At,were
R1228 T2452 T2453 amod postnatal,day
R1229 T2453 T2450 pobj day,At
R1230 T2454 T2453 nummod 21,day
R1231 T2455 T2453 punct (,day
R1232 T2456 T2453 appos P21,day
R1233 T2457 T2451 punct ),were
R1234 T2458 T2451 punct ", ",were
R1235 T2459 T2460 advmod when,exhibited
R1236 T2460 T2451 advcl exhibited,were
R1237 T2461 T2462 nmod Crx,photoreceptors
R1238 T2462 T2460 nsubj photoreceptors,exhibited
R1239 T2463 T2461 punct +,Crx
R1240 T2464 T2461 punct /,Crx
R1241 T2465 T2461 punct +,Crx
R1242 T2466 T2467 amod robust,segments
R1243 T2467 T2460 dobj segments,exhibited
R1244 T2468 T2467 amod outer,segments
R1245 T2469 T2470 punct (,os
R1246 T2470 T2460 parataxis os,exhibited
R1247 T2471 T2472 compound Figure,1A
R1248 T2472 T2470 dep 1A,os
R1249 T2473 T2470 punct ", ",os
R1250 T2474 T2470 punct ),os
R1251 T2475 T2451 punct ", ",were
R1252 T2476 T2477 nmod Crx,retinas
R1253 T2477 T2451 nsubj retinas,were
R1254 T2478 T2476 punct -,Crx
R1255 T2479 T2476 punct /,Crx
R1256 T2480 T2476 punct -,Crx
R1257 T2481 T2451 prep without,were
R1258 T2482 T2483 det a,layer
R1259 T2483 T2481 pobj layer,without
R1260 T2484 T2483 amod recognizable,layer
R1261 T2485 T2486 amod outer,segment
R1262 T2486 T2483 compound segment,layer
R1263 T2487 T2488 punct (,Figure
R1264 T2488 T2451 parataxis Figure,were
R1265 T2489 T2488 nummod 1B,Figure
R1266 T2490 T2488 punct ),Figure
R1267 T2491 T2451 punct .,were
R1268 T2493 T2494 nmod Crx,photoreceptors
R1269 T2494 T2498 nsubj photoreceptors,had
R1270 T2495 T2493 punct -,Crx
R1271 T2496 T2493 punct /,Crx
R1272 T2497 T2493 punct -,Crx
R1273 T2499 T2500 amod inner,segments
R1274 T2500 T2498 dobj segments,had
R1275 T2501 T2498 punct ", ",had
R1276 T2502 T2498 advcl demonstrating,had
R1277 T2503 T2504 advmod at,least
R1278 T2504 T2505 advmod least,limited
R1279 T2505 T2506 amod limited,polarization
R1280 T2506 T2502 dobj polarization,demonstrating
R1281 T2507 T2506 compound photoreceptor,polarization
R1282 T2508 T2506 prep in,polarization
R1283 T2509 T2510 det the,mutant
R1284 T2510 T2508 pobj mutant,in
R1285 T2511 T2510 compound Crx,mutant
R1286 T2512 T2498 punct ", ",had
R1287 T2513 T2498 cc but,had
R1288 T2514 T2515 det the,segments
R1289 T2515 T2517 nsubj segments,were
R1290 T2516 T2515 amod inner,segments
R1291 T2517 T2498 conj were,had
R1292 T2518 T2519 advmod extremely,short
R1293 T2519 T2517 acomp short,were
R1294 T2520 T2521 punct (,Figure
R1295 T2521 T2517 parataxis Figure,were
R1296 T2522 T2521 nummod 2,Figure
R1297 T2523 T2521 punct ),Figure
R1298 T2524 T2517 punct .,were
R1299 T2526 T2527 advmod Furthermore,showed
R1300 T2528 T2527 punct ", ",showed
R1301 T2529 T2530 det the,majority
R1302 T2530 T2527 nsubj majority,showed
R1303 T2531 T2530 prep of,majority
R1304 T2532 T2533 amod inner,segments
R1305 T2533 T2531 pobj segments,of
R1306 T2534 T2535 det some,differentiation
R1307 T2535 T2527 dobj differentiation,showed
R1308 T2536 T2535 amod morphological,differentiation
R1309 T2537 T2527 punct ", ",showed
R1310 T2538 T2527 advcl having,showed
R1311 T2539 T2540 advmod approximately,many
R1312 T2540 T2542 amod many,mitochondria
R1313 T2541 T2540 advmod as,many
R1314 T2542 T2538 dobj mitochondria,having
R1315 T2543 T2542 prep as,mitochondria
R1316 T2544 T2545 det the,control
R1317 T2545 T2543 pobj control,as
R1318 T2546 T2547 punct (,1
R1319 T2547 T2538 parataxis 1,having
R1320 T2548 T2547 nmod Figure,1
R1321 T2549 T2547 cc and,1
R1322 T2550 T2547 conj 2,1
R1323 T2551 T2547 punct ),1
R1324 T2552 T2527 punct .,showed
R1325 T2554 T2555 advmod Occasionally,noted
R1326 T2556 T2555 punct ", ",noted
R1327 T2557 T2558 det an,segment
R1328 T2558 T2555 nsubjpass segment,noted
R1329 T2559 T2558 amod inner,segment
R1330 T2560 T2558 acl undergoing,segment
R1331 T2561 T2560 dobj lysis,undergoing
R1332 T2562 T2555 auxpass was,noted
R1333 T2563 T2555 punct ", ",noted
R1334 T2564 T2555 advcl appearing,noted
R1335 T2565 T2564 oprd swollen,appearing
R1336 T2566 T2565 cc or,swollen
R1337 T2567 T2565 conj with,swollen
R1338 T2568 T2567 pobj vacuoles,with
R1339 T2569 T2568 cc and,vacuoles
R1340 T2570 T2571 amod swollen,mitochondria
R1341 T2571 T2568 conj mitochondria,vacuoles
R1342 T2572 T2573 punct (,shown
R1343 T2573 T2564 parataxis shown,appearing
R1344 T2574 T2573 nsubj data,shown
R1345 T2575 T2573 neg not,shown
R1346 T2576 T2573 punct ),shown
R1347 T2577 T2555 punct .,noted
R1389 T2654 T2638 auxpass were,noted
R1390 T2655 T2656 punct (,3A
R1391 T2656 T2638 parataxis 3A,noted
R1392 T2657 T2656 nmod Figure,3A
R1393 T2658 T2656 cc and,3A
R1394 T2659 T2656 conj 3B,3A
R1395 T2660 T2656 punct ),3A
R1396 T2661 T2638 punct .,noted
R1397 T2663 T2664 advmod Sporadically,contained
R1398 T2665 T2664 punct ", ",contained
R1399 T2666 T2667 amod connecting,cilia
R1400 T2667 T2664 nsubj cilia,contained
R1401 T2668 T2664 dobj other,contained
R1402 T2669 T2668 prep than,other
R1403 T2670 T2671 det the,complement
R1404 T2671 T2669 pobj complement,than
R1405 T2672 T2671 amod typical,complement
R1406 T2673 T2671 prep of,complement
R1407 T2674 T2675 compound microtubule,doublets
R1408 T2675 T2673 pobj doublets,of
R1409 T2676 T2664 punct .,contained
R1410 T2678 T2679 prep For,shows
R1411 T2680 T2678 pobj example,For
R1412 T2681 T2679 punct ", ",shows
R1413 T2682 T2679 prep in,shows
R1414 T2683 T2684 compound Figure,3A
R1415 T2684 T2682 pobj 3A,in
R1416 T2685 T2679 punct ", ",shows
R1417 T2686 T2687 det the,cilium
R1418 T2687 T2679 nsubj cilium,shows
R1419 T2688 T2687 amod connecting,cilium
R1420 T2689 T2687 acl labelled,cilium
R1421 T2690 T2689 agent by,labelled
R1422 T2691 T2690 pobj arrowhead,by
R1423 T2692 T2691 nummod 1,arrowhead
R1424 T2693 T2679 punct ", ",shows
R1425 T2694 T2695 nummod 7,0
R1426 T2695 T2697 nummod 0,doublets
R1427 T2696 T2695 punct +,0
R1428 T2697 T2679 dobj doublets,shows
R1429 T2698 T2679 punct .,shows
R1430 T2700 T2701 det The,majority
R1431 T2701 T2702 nsubj majority,exhibited
R1432 T2703 T2704 det the,doublets
R1433 T2704 T2702 dobj doublets,exhibited
R1434 T2705 T2704 amod characteristic,doublets
R1435 T2706 T2707 nummod 9,0
R1436 T2707 T2704 nummod 0,doublets
R1437 T2708 T2707 punct +,0
R1438 T2709 T2710 punct (,2
R1439 T2710 T2702 parataxis 2,exhibited
R1440 T2711 T2710 nmod arrowhead,2
R1441 T2712 T2710 cc and,2
R1442 T2713 T2710 conj 3,2
R1443 T2714 T2710 prep in,2
R1444 T2715 T2716 compound Figure,3A
R1445 T2716 T2714 pobj 3A,in
R1446 T2717 T2716 cc and,3A
R1447 T2718 T2719 compound Figure,3B
R1448 T2719 T2716 conj 3B,3A
R1449 T2720 T2710 punct ),2
R1450 T2721 T2702 punct .,exhibited
R1451 T2723 T2724 det These,observations
R1452 T2724 T2725 nsubj observations,indicate
R1453 T2726 T2727 mark that,is
R1454 T2727 T2725 ccomp is,indicate
R1455 T2728 T2727 prep in,is
R1456 T2729 T2728 pobj addition,in
R1457 T2730 T2729 prep to,addition
R1458 T2731 T2732 amod inner,segment
R1459 T2732 T2733 compound segment,formation
R1460 T2733 T2730 pobj formation,to
R1461 T2734 T2727 punct ", ",is
R1462 T2735 T2727 nsubj ciliogenesis,is
R1463 T2736 T2727 advmod also,is
R1464 T2737 T2738 advmod largely,intact
R1465 T2738 T2727 acomp intact,is
R1466 T2739 T2727 prep in,is
R1467 T2740 T2741 nmod Crx,photoreceptors
R1469 T2742 T2740 punct -,Crx
R1470 T2743 T2740 punct /,Crx
R1542 T2848 T2849 punct (,mx
R1543 T2849 T2837 parataxis mx,noted
R1544 T2850 T2851 compound Figure,3A
R1545 T2851 T2849 dep 3A,mx
R1546 T2852 T2849 punct ", ",mx
R1547 T2853 T2849 punct ),mx
R1548 T2854 T2837 punct .,noted
R1549 T2856 T2857 advmod Second,found
R1550 T2858 T2857 punct ", ",found
R1551 T2859 T2860 advmod sporadically,displaced
R1552 T2860 T2861 amod displaced,nuclei
R1553 T2861 T2857 nsubjpass nuclei,found
R1554 T2862 T2857 auxpass were,found
R1555 T2863 T2857 advcl residing,found
R1556 T2864 T2863 prep in,residing
R1557 T2865 T2866 det the,space
R1558 T2866 T2864 pobj space,in
R1559 T2867 T2866 acl abutting,space
R1560 T2868 T2869 det the,PE
R1561 T2869 T2867 dobj PE,abutting
R1562 T2870 T2857 punct .,found
R1563 T2872 T2873 advmod Occasionally,appeared
R1564 T2874 T2873 punct ", ",appeared
R1565 T2875 T2876 det these,nuclei
R1566 T2876 T2873 nsubj nuclei,appeared
R1567 T2877 T2873 oprd pyknotic,appeared
R1568 T2878 T2879 punct (,n
R1569 T2879 T2873 parataxis n,appeared
R1570 T2880 T2881 compound Figure,3A
R1571 T2881 T2879 dep 3A,n
R1572 T2882 T2879 punct ", ",n
R1573 T2883 T2879 punct ),n
R1574 T2884 T2873 punct ;,appeared
R1575 T2885 T2873 cc but,appeared
R1576 T2886 T2873 punct ", ",appeared
R1577 T2887 T2888 advmod more,frequently
R1578 T2888 T2889 advmod frequently,exhibited
R1579 T2889 T2873 conj exhibited,appeared
R1580 T2890 T2891 det the,pattern
R1581 T2891 T2889 dobj pattern,exhibited
R1582 T2892 T2891 compound heterochromatin,pattern
R1583 T2893 T2891 amod typical,pattern
R1584 T2894 T2893 prep of,typical
R1585 T2895 T2894 pobj photoreceptors,of
R1586 T2896 T2897 punct (,shown
R1587 T2897 T2889 parataxis shown,exhibited
R1588 T2898 T2897 nsubj data,shown
R1589 T2899 T2897 neg not,shown
R1590 T2900 T2897 punct ),shown
R1591 T2901 T2889 punct ", ",exhibited
R1592 T2902 T2903 advmod strongly,suggesting
R1593 T2903 T2889 advcl suggesting,exhibited
R1594 T2904 T2905 mark that,belonged
R1595 T2905 T2903 ccomp belonged,suggesting
R1596 T2906 T2905 nsubj they,belonged
R1597 T2907 T2905 prep to,belonged
R1598 T2908 T2909 amod ectopic,photoreceptors
R1599 T2909 T2907 pobj photoreceptors,to
R1600 T2910 T2873 punct .,appeared
R1601 T2912 T2913 det The,entity
R1602 T2913 T2916 nsubj entity,were
R1603 T2914 T2913 amod third,entity
R1604 T2915 T2913 amod pathological,entity
R1605 T2917 T2913 acl noted,entity
R1606 T2918 T2917 prep in,noted
R1607 T2919 T2920 det the,layer
R1608 T2920 T2918 pobj layer,in
R1609 T2921 T2922 amod outer,segment
R1610 T2922 T2920 compound segment,layer
R1611 T2923 T2924 amod numerous,vesicles
R1612 T2924 T2916 attr vesicles,were
R1613 T2925 T2924 amod small,vesicles
R1614 T2926 T2927 punct (,arrow
R1615 T2927 T2924 parataxis arrow,vesicles
R1616 T2928 T2929 compound Figure,3A
R1617 T2929 T2927 compound 3A,arrow
R1618 T2930 T2927 punct ),arrow
R1619 T2931 T2932 quantmod 100,200
R1620 T2932 T2934 nummod 200,nm
R1621 T2933 T2932 quantmod to,200
R1622 T2934 T2924 appos nm,vesicles
R1623 T2935 T2934 prep in,nm
R1624 T2936 T2935 pobj diameter,in
R1625 T2937 T2916 punct .,were
R1626 T2939 T2940 nsubj They,appeared
R1627 T2941 T2942 aux to,emerging
R1628 T2942 T2940 xcomp emerging,appeared
R1629 T2943 T2942 aux be,emerging
R1630 T2944 T2942 prep from,emerging
R1631 T2945 T2946 det the,segments
R1632 T2946 T2944 pobj segments,from
R1633 T2947 T2946 amod inner,segments
R1634 T2948 T2940 punct ", ",appeared
R1635 T2949 T2950 mark as,showed
R1636 T2950 T2940 advcl showed,appeared
R1637 T2951 T2952 amod scanning,electron
R1638 T2952 T2953 npadvmod electron,microscopic
R1639 T2953 T2954 amod microscopic,images
R1640 T2954 T2950 nsubj images,showed
R1641 T2955 T2956 amod spherical,structures
R1642 T2956 T2950 dobj structures,showed
R1643 T2957 T2956 acl budding,structures
R1644 T2958 T2957 prep from,budding
R1645 T2959 T2960 det the,segments
R1646 T2960 T2958 pobj segments,from
R1647 T2961 T2960 amod inner,segments
R1648 T2962 T2963 punct (,arrow
R1649 T2963 T2950 parataxis arrow,showed
R1650 T2964 T2965 compound Figure,3C
R1651 T2965 T2963 dep 3C,arrow
R1652 T2966 T2963 punct ", ",arrow
R1653 T2967 T2963 punct ),arrow
R1654 T2968 T2940 punct .,appeared
R1655 T2970 T2971 prep In,viewed
R1656 T2972 T2970 pobj order,In
R1657 T2973 T2974 aux to,characterize
R1658 T2974 T2972 acl characterize,order
R1659 T2975 T2974 advmod further,characterize
R1660 T2976 T2977 det the,morphogenesis
R1661 T2977 T2974 dobj morphogenesis,characterize
R1662 T2978 T2977 prep of,morphogenesis
R1663 T2979 T2980 nmod Crx,photoreceptors
R1664 T2980 T2978 pobj photoreceptors,of
R1665 T2981 T2979 punct -,Crx
R1666 T2982 T2979 punct /,Crx
R1667 T2983 T2979 punct -,Crx
R1668 T2984 T2971 punct ", ",viewed
R1669 T2985 T2986 det the,layer
R1670 T2986 T2971 nsubjpass layer,viewed
R1671 T2987 T2986 amod developing,layer
R1672 T2988 T2989 amod outer,segment
R1673 T2989 T2986 compound segment,layer
R1674 T2990 T2971 auxpass was,viewed
R1675 T2991 T2971 prep by,viewed
R1676 T2992 T2993 amod scanning,microscopy
R1677 T2993 T2991 pobj microscopy,by
R1678 T2994 T2993 compound electron,microscopy
R1679 T2995 T2971 prep at,viewed
R1680 T2996 T2995 pobj P7,at
R1681 T2997 T2996 punct ", ",P7
R1682 T2998 T2996 conj P14,P7
R1683 T2999 T2998 cc and,P14
R1684 T3000 T2998 conj P21,P14
R1685 T3001 T3002 punct (,Figure
R1686 T3002 T2971 parataxis Figure,viewed
R1687 T3003 T3002 nummod 4,Figure
R1688 T3004 T3002 punct ),Figure
R1689 T3005 T2971 punct .,viewed
R1690 T3007 T3008 prep In,noted
R1691 T3009 T3010 nmod Crx,retinas
R1692 T3010 T3007 pobj retinas,In
R1693 T3011 T3009 punct +,Crx
R1694 T3012 T3009 punct /,Crx
R1695 T3013 T3009 punct +,Crx
R1696 T3014 T3008 punct ", ",noted
R1697 T3015 T3016 nmod photoreceptor,segments
R1698 T3016 T3008 nsubjpass segments,noted
R1699 T3017 T3016 amod inner,segments
R1700 T3018 T3016 punct ", ",segments
R1701 T3019 T3020 amod connecting,cilia
R1702 T3020 T3016 conj cilia,segments
R1703 T3021 T3020 punct ", ",cilia
R1704 T3022 T3020 cc and,cilia
R1705 T3023 T3024 det the,structures
R1706 T3024 T3020 conj structures,cilia
R1707 T3025 T3024 amod first,structures
R1708 T3026 T3024 amod rudimentary,structures
R1709 T3027 T3028 amod outer,segment
R1710 T3028 T3024 compound segment,structures
R1711 T3029 T3008 auxpass were,noted
R1712 T3030 T3008 prep at,noted
R1713 T3031 T3030 pobj P7,at
R1714 T3032 T3008 punct .,noted
R1715 T3034 T3035 prep In,emerging
R1716 T3036 T3037 det the,retina
R1717 T3037 T3034 pobj retina,In
R1718 T3038 T3037 nmod Crx,retina
R1719 T3039 T3038 punct -,Crx
R1720 T3040 T3038 punct /,Crx
R1721 T3041 T3038 punct -,Crx
R1722 T3042 T3035 punct ", ",emerging
R1723 T3043 T3044 advmod only,cilium
R1724 T3044 T3035 nsubjpass cilium,emerging
R1725 T3045 T3044 det an,cilium
R1726 T3046 T3044 amod occassional,cilium
R1727 T3047 T3044 amod connecting,cilium
R1728 T3048 T3035 auxpass was,emerging
R1729 T3049 T3035 aux noted,emerging
R1730 T3050 T3035 prep from,emerging
R1731 T3051 T3052 amod inner,segments
R1732 T3052 T3050 pobj segments,from
R1733 T3053 T3035 prep at,emerging
R1734 T3054 T3055 det this,stage
R1735 T3055 T3053 pobj stage,at
R1736 T3056 T3057 punct (,4A
R1737 T3057 T3035 parataxis 4A,emerging
R1738 T3058 T3057 compound Figure,4A
R1739 T3059 T3057 cc and,4A
R1740 T3060 T3057 conj 4B,4A
R1741 T3061 T3057 punct ),4A
R1742 T3062 T3035 punct .,emerging
R1743 T3064 T3065 det This,observation
R1744 T3065 T3066 nsubjpass observation,confirmed
R1745 T3067 T3066 auxpass was,confirmed
R1746 T3068 T3066 prep by,confirmed
R1747 T3069 T3068 pobj comparison,by
R1748 T3070 T3069 prep with,comparison
R1749 T3071 T3072 compound transmission,micrographs
R1750 T3072 T3070 pobj micrographs,with
R1751 T3073 T3072 compound electron,micrographs
R1752 T3074 T3075 punct (,Figure
R1753 T3075 T3066 parataxis Figure,confirmed
R1754 T3076 T3075 nummod 5,Figure
R1755 T3077 T3075 punct ),Figure
R1756 T3078 T3066 punct .,confirmed
R1757 T3080 T3081 det These,differences
R1758 T3081 T3082 nsubj differences,are
R1759 T3083 T3084 det the,differences
R1760 T3084 T3082 attr differences,are
R1761 T3085 T3084 amod earliest,differences
R1762 T3086 T3084 amod noted,differences
R1763 T3087 T3084 prep between,differences
R1764 T3088 T3089 nmod Crx,photoreceptors
R1765 T3089 T3087 pobj photoreceptors,between
R1766 T3090 T3088 punct +,Crx
R1767 T3091 T3088 punct /,Crx
R1768 T3092 T3088 punct +,Crx
R1769 T3093 T3088 cc and,Crx
R1770 T3094 T3088 conj Crx,Crx
R1771 T3095 T3094 punct -,Crx
R1772 T3096 T3094 punct /,Crx
R1773 T3097 T3094 punct -,Crx
R1774 T3098 T3082 punct .,are
R1775 T3100 T3101 prep At,noted
R1776 T3102 T3100 pobj P14,At
R1777 T3103 T3101 punct ", ",noted
R1778 T3104 T3105 amod elongating,segments
R1779 T3105 T3101 nsubjpass segments,noted
R1780 T3106 T3105 amod outer,segments
R1781 T3107 T3101 auxpass were,noted
R1782 T3108 T3101 prep on,noted
R1783 T3109 T3110 nmod Crx,photoreceptors
R1784 T3110 T3108 pobj photoreceptors,on
R1785 T3111 T3109 punct +,Crx
R1786 T3112 T3109 punct /,Crx
R1787 T3113 T3109 punct +,Crx
R1788 T3114 T3101 punct ", ",noted
R1789 T3115 T3116 advmod occasionally,demonstrating
R1790 T3116 T3101 advcl demonstrating,noted
R1791 T3117 T3118 det a,structure
R1792 T3118 T3116 dobj structure,demonstrating
R1793 T3119 T3120 npadvmod paddle,like
R1794 T3120 T3118 amod like,structure
R1795 T3121 T3120 punct -,like
R1796 T3122 T3116 prep at,demonstrating
R1797 T3123 T3124 poss their,apex
R1798 T3124 T3122 pobj apex,at
R1799 T3125 T3126 punct (,os
R1800 T3126 T3116 parataxis os,demonstrating
R1801 T3127 T3128 compound Figure,4C
R1802 T3128 T3126 dep 4C,os
R1803 T3129 T3126 punct ", ",os
R1804 T3130 T3126 punct ),os
R1805 T3131 T3101 punct .,noted
R1806 T3133 T3134 prep In,demonstrated
R1807 T3135 T3136 nmod Crx,retinae
R1808 T3136 T3133 pobj retinae,In
R1809 T3137 T3135 punct -,Crx
R1810 T3138 T3135 punct /,Crx
R1811 T3139 T3135 punct -,Crx
R1812 T3140 T3134 punct ", ",demonstrated
R1813 T3141 T3142 det the,majority
R1814 T3142 T3134 nsubj majority,demonstrated
R1815 T3143 T3142 amod vast,majority
R1816 T3144 T3142 prep of,majority
R1817 T3145 T3144 pobj photoreceptors,of
R1818 T3153 T3151 pobj segments,without
R1819 T3146 T3145 prep at,photoreceptors
R1820 T3154 T3155 punct (,cc
R1821 T3147 T3148 det this,stage
R1822 T3155 T3134 parataxis cc,demonstrated
R1823 T3156 T3157 compound Figure,4D
R1824 T3148 T3146 pobj stage,at
R1825 T3157 T3155 dep 4D,cc
R1826 T3158 T3155 punct ", ",cc
R1827 T3149 T3150 amod connecting,cilia
R1828 T3159 T3155 punct ),cc
R1829 T3160 T3134 punct .,demonstrated
R1830 T3150 T3134 dobj cilia,demonstrated
R1831 T3162 T3163 advmod Sporadically,exhibit
R1832 T3151 T3150 prep without,cilia
R1833 T3164 T3163 punct ", ",exhibit
R1834 T3165 T3166 nmod Crx,photoreceptors
R1835 T3166 T3163 nsubj photoreceptors,exhibit
R1836 T3152 T3153 amod outer,segments
R1837 T3167 T3165 punct -,Crx
R1838 T3168 T3165 punct /,Crx
R1839 T3258 T3259 compound Figure,4F
R1840 T3169 T3165 punct -,Crx
R1841 T3170 T3163 aux would,exhibit
R1842 T3171 T3172 det an,structure
R1843 T3259 T3257 dep 4F,cc
R1844 T3172 T3163 dobj structure,exhibit
R1845 T3173 T3172 amod irregular,structure
R1846 T3174 T3172 acl extending,structure
R1847 T3260 T3257 punct ", ",cc
R1848 T3175 T3174 prep from,extending
R1849 T3176 T3177 det a,cilium
R1850 T3177 T3175 pobj cilium,from
R1851 T3261 T3257 punct ),cc
R1852 T3178 T3177 amod connecting,cilium
R1853 T3179 T3180 punct (,cc*
R1854 T3262 T3242 punct .,noted
R1855 T3180 T3174 parataxis cc*,extending
R1856 T3181 T3182 compound Figure,4D
R1857 T3182 T3180 dep 4D,cc*
R1858 T3183 T3180 punct ", ",cc*
R1859 T3264 T3265 amod Serial,examination
R1860 T3184 T3180 punct ),cc*
R1861 T3185 T3186 advmod perhaps,representing
R1862 T3186 T3172 acl representing,structure
R1863 T3265 T3266 nsubj examination,demonstrated
R1864 T3187 T3188 det a,segment
R1865 T3188 T3186 dobj segment,representing
R1866 T3189 T3188 amod malformed,segment
R1867 T3190 T3188 amod outer,segment
R1868 T3191 T3163 punct .,exhibit
R1869 T3267 T3265 prep of,examination
R1870 T3193 T3194 amod Such,structures
R1871 T3194 T3195 nsubjpass structures,observed
R1872 T3196 T3195 auxpass were,observed
R1873 T3197 T3195 dobj also,observed
R1874 T3268 T3269 nmod Crx,photoreceptors
R1875 T3198 T3195 prep at,observed
R1876 T3199 T3198 pobj P21,at
R1877 T3269 T3267 pobj photoreceptors,of
R1878 T3200 T3201 punct (,cc*
R1879 T3201 T3195 parataxis cc*,observed
R1880 T3202 T3203 compound Figure,4F
R1881 T3270 T3268 punct -,Crx
R1882 T3203 T3201 dep 4F,cc*
R1883 T3204 T3201 punct ", ",cc*
R1884 T3205 T3201 punct ),cc*
R1885 T3271 T3268 punct /,Crx
R1886 T3206 T3195 punct .,observed
R1887 T3272 T3268 punct -,Crx
R1888 T3208 T3209 det These,segments
R1889 T3209 T3214 nsubjpass segments,noted
R1890 T3210 T3209 amod putative,segments
R1891 T3273 T3265 prep at,examination
R1892 T3211 T3209 punct ", ",segments
R1893 T3212 T3209 amod abnormal,segments
R1894 T3213 T3209 amod outer,segments
R1895 T3274 T3273 pobj P7,at
R1896 T3215 T3214 auxpass were,noted
R1897 T3216 T3217 advmod only,rarely
R1898 T3275 T3274 punct ", ",P7
R1899 T3217 T3214 advmod rarely,noted
R1900 T3276 T3274 conj P10,P7
R1901 T3277 T3276 punct ", ",P10
R1902 T3218 T3214 prep in,noted
R1903 T3219 T3218 pobj Crx,in
R1904 T3278 T3276 conj P14,P10
R1905 T3220 T3219 punct +,Crx
R1906 T3221 T3219 punct /,Crx
R1907 T3222 T3219 punct +,Crx
R1908 T3279 T3278 punct ", ",P14
R1909 T3280 T3278 cc and,P14
R1910 T3223 T3214 prep at,noted
R1911 T3224 T3223 pobj P14,at
R1912 T3281 T3278 conj P21,P14
R1913 T3225 T3214 punct ", ",noted
R1914 T3226 T3214 cc and,noted
R1915 T3282 T3265 prep by,examination
R1916 T3227 T3214 conj never,noted
R1917 T3228 T3227 prep at,never
R1918 T3229 T3228 pobj P21,at
R1919 T3230 T3231 punct (,cc
R1920 T3231 T3227 parataxis cc,never
R1921 T3283 T3282 pobj TEM,by
R1922 T3232 T3233 compound Figure,4C
R1923 T3233 T3231 dep 4C,cc
R1924 T3234 T3233 cc and,4C
R1925 T3284 T3266 punct ", ",demonstrated
R1926 T3235 T3233 conj 4E,4C
R1927 T3236 T3231 punct ", ",cc
R1928 T3237 T3231 punct *,cc
R1929 T3285 T3286 det a,lack
R1930 T3238 T3231 punct ),cc
R1931 T3239 T3214 punct .,noted
R1932 T3286 T3266 dobj lack,demonstrated
R1933 T3241 T3242 advmod Further,noted
R1934 T3243 T3242 punct ", ",noted
R1935 T3287 T3286 amod distinctive,lack
R1936 T3244 T3242 prep in,noted
R1937 T3245 T3246 nmod Crx,photoreceptors
R1938 T3246 T3244 pobj photoreceptors,in
R1939 T3288 T3286 prep of,lack
R1940 T3247 T3245 punct -,Crx
R1941 T3248 T3245 punct /,Crx
R1942 T3249 T3245 punct -,Crx
R1943 T3289 T3290 det any,structure
R1944 T3250 T3242 punct ", ",noted
R1945 T3251 T3252 advmod unusually,long
R1946 T3290 T3288 pobj structure,of
R1947 T3252 T3253 amod long,cilia
R1948 T3253 T3242 nsubjpass cilia,noted
R1949 T3254 T3253 amod connecting,cilia
R1950 T3291 T3290 amod interpretable,structure
R1951 T3255 T3242 auxpass were,noted
R1952 T3256 T3257 punct (,cc
R1953 T3257 T3242 parataxis cc,noted
R1954 T3292 T3291 prep as,interpretable
R1955 T3293 T3294 amod orderly,stacks
R1956 T3294 T3292 pobj stacks,as
R1957 T3295 T3294 prep of,stacks
R1958 T3296 T3295 pobj discs,of
R1959 T3297 T3296 cc or,discs
R1960 T3298 T3299 amod forming,discs
R1961 T3299 T3296 conj discs,discs
R1962 T3300 T3266 punct .,demonstrated
R1963 T3302 T3303 det These,data
R1965 T3303 T3304 nsubj data,demonstrate
R1966 T3305 T3306 det a,absence
R1967 T3306 T3304 dobj absence,demonstrate
R1968 T3307 T3306 amod complete,absence
R1969 T3308 T3306 prep of,absence
R1970 T3309 T3310 amod normal,formation
R1988 T3377 T3375 pobj photoreceptors,to
R1990 T3378 T3376 punct -,rhodopsin
R1991 T3379 T3376 punct /,rhodopsin
R1992 T3380 T3376 punct -,rhodopsin
R1994 T3381 T3376 cc and,rhodopsin
R1995 T3382 T3376 conj peripherin,rhodopsin
R1996 T3383 T3382 punct -,peripherin
R1998 T3384 T3382 punct /,peripherin
R1999 T3385 T3382 punct -,peripherin
R2000 T3386 T3365 punct .,compared
R2005 T3388 T3389 nsubj Rhodopsin,are
R2006 T3390 T3388 cc and,Rhodopsin
R2008 T3391 T3388 conj peripherin,Rhodopsin
R2009 T3392 T3393 nummod two,genes
R2011 T3393 T3389 attr genes,are
R2012 T3394 T3395 npadvmod photoreceptor,specific
R2013 T3395 T3393 amod specific,genes
R2015 T3396 T3395 punct -,specific
R2016 T3397 T3398 poss whose,expression
R2017 T3398 T3399 dep expression,downregulated
R2019 T3399 T3393 relcl downregulated,genes
R2020 T3400 T3399 auxpass is,downregulated
R2021 T3401 T3399 advmod significantly,downregulated
R2023 T3402 T3399 prep in,downregulated
R2024 T3403 T3404 det the,retinae
R2025 T3404 T3402 pobj retinae,in
R2026 T3405 T3404 nmod Crx,retinae
R2027 T3406 T3405 punct -,Crx
R2029 T3407 T3405 punct /,Crx
R2030 T3408 T3405 punct -,Crx
R2031 T3409 T3410 punct [,35
R2032 T3410 T3399 parataxis 35,downregulated
R2034 T3411 T3410 nummod 10,35
R2035 T3412 T3410 punct ",",35
R2037 T3413 T3410 nummod 34,35
R2038 T3414 T3410 punct ",",35
R2039 T3415 T3410 punct ],35
R2041 T3416 T3389 punct .,are
R2043 T3418 T3419 nmod Loss,mutations
R2044 T3419 T3422 nsubjpass mutations,reported
R2045 T3420 T3418 prep of,Loss
R2047 T3421 T3420 pobj function,of
R2048 T3423 T3419 prep in,mutations
R2050 T3424 T3423 pobj each,in
R2051 T3425 T3424 prep of,each
R2052 T3426 T3427 det these,genes
R2054 T3427 T3425 pobj genes,of
R2055 T3428 T3422 advmod separately,reported
R2056 T3429 T3422 aux have,reported
R2057 T3430 T3422 auxpass been,reported
R2058 T3431 T3432 aux to,result
R2059 T3432 T3422 xcomp result,reported
R2060 T3433 T3432 prep in,result
R2061 T3434 T3435 det a,failure
R2062 T3435 T3433 pobj failure,in
R2063 T3436 T3437 aux to,elaborate
R2064 T3437 T3435 acl elaborate,failure
R2065 T3438 T3439 amod outer,segments
R2066 T3439 T3437 dobj segments,elaborate
R2067 T3440 T3441 punct [,30
R2068 T3441 T3422 parataxis 30,reported
R2069 T3442 T3441 nummod 29,30
R2070 T3443 T3441 punct ",",30
R2071 T3444 T3441 punct ],30
R2072 T3445 T3422 punct .,reported
R2073 T3447 T3448 nsubj Photoreceptors,appeared
R2074 T3449 T3447 prep from,Photoreceptors
R2075 T3450 T3451 det these,mice
R2076 T3451 T3449 pobj mice,from
R2077 T3452 T3451 nummod two,mice
R2078 T3453 T3451 amod mutant,mice
R2079 T3454 T3451 acl examined,mice
R2080 T3455 T3454 prep by,examined
R2081 T3456 T3455 pobj SEM,by
R2082 T3457 T3454 prep from,examined
R2083 T3458 T3459 det the,side
R2084 T3459 T3457 pobj side,from
R2085 T3460 T3459 amod scleral,side
R2086 T3461 T3462 advmod highly,similar
R2087 T3462 T3448 oprd similar,appeared
R2088 T3463 T3462 prep to,similar
R2089 T3464 T3465 nmod Crx,photoreceptors
R2090 T3465 T3463 pobj photoreceptors,to
R2091 T3466 T3464 punct -,Crx
R2092 T3467 T3464 punct /,Crx
R2093 T3468 T3464 punct -,Crx
R2094 T3469 T3470 punct (,compare
R2095 T3470 T3448 parataxis compare,appeared
R2096 T3471 T3472 compound Figure,4F
R2097 T3472 T3470 dobj 4F,compare
R2098 T3473 T3470 prep to,compare
R2099 T3474 T3475 compound Figure,6A
R2100 T3475 T3473 pobj 6A,to
R2101 T3476 T3475 cc and,6A
R2102 T3477 T3475 conj 6B,6A
R2103 T3478 T3470 punct ),compare
R2104 T3479 T3448 punct .,appeared
R2111 T3638 T3639 nsubj Crx,is
R2112 T3640 T3639 acomp necessary,is
R2113 T3641 T3640 prep for,necessary
R2114 T3642 T3643 det the,formation
R2115 T3643 T3641 pobj formation,for
R2116 T3644 T3643 prep of,formation
R2117 T3645 T3646 compound photoreceptor,terminals
R2118 T3646 T3644 pobj terminals,of
R2119 T3648 T3649 prep In,demonstrated
R2120 T3650 T3651 det a,study
R2121 T3651 T3648 pobj study,In
R2122 T3652 T3651 amod previous,study
R2123 T3653 T3649 punct ", ",demonstrated
R2124 T3654 T3649 nsubj we,demonstrated
R2125 T3655 T3656 mark that,blocked
R2126 T3656 T3649 ccomp blocked,demonstrated
R2127 T3657 T3658 amod forced,expression
R2128 T3658 T3656 nsubj expression,blocked
R2129 T3659 T3658 prep of,expression
R2130 T3660 T3661 det a,allele
R2131 T3661 T3659 pobj allele,of
R2132 T3662 T3663 amod dominant,negative
R2133 T3663 T3661 amod negative,allele
R2134 T3664 T3663 punct -,negative
R2135 T3665 T3661 prep of,allele
R2136 T3666 T3665 pobj Crx,of
R2137 T3667 T3658 prep in,expression
R2138 T3668 T3669 amod developing,rods
R2139 T3669 T3667 pobj rods,in
R2140 T3670 T3656 dobj formation,blocked
R2141 T3671 T3670 prep of,formation
R2142 T3672 T3673 det both,spherules
R2143 T3673 T3671 pobj spherules,of
R2144 T3674 T3673 compound rod,spherules
R2145 T3675 T3656 prep in,blocked
R2146 T3676 T3677 det the,layer
R2147 T3677 T3675 pobj layer,in
R2148 T3678 T3677 amod outer,layer
R2149 T3679 T3677 compound plexiform,layer
R2150 T3680 T3677 punct (,layer
R2151 T3681 T3677 appos OPL,layer
R2152 T3682 T3677 punct ),layer
R2153 T3683 T3677 cc and,layer
R2154 T3684 T3685 amod outer,segments
R2155 T3685 T3677 conj segments,layer
R2156 T3686 T3687 punct [,7
R2157 T3687 T3649 parataxis 7,demonstrated
R2158 T3688 T3687 punct ],7
R2159 T3689 T3649 punct .,demonstrated
R2160 T3691 T3692 aux To,expand
R2161 T3692 T3693 advcl expand,examined
R2162 T3694 T3692 prep on,expand
R2163 T3695 T3696 det these,studies
R2164 T3696 T3694 pobj studies,on
R2165 T3697 T3693 punct ", ",examined
R2166 T3698 T3699 det the,ultrastructure
R2167 T3699 T3693 nsubjpass ultrastructure,examined
R2168 T3700 T3699 prep of,ultrastructure
R2169 T3701 T3702 compound photoreceptor,synapses
R2170 T3702 T3700 pobj synapses,of
R2171 T3703 T3693 auxpass was,examined
R2172 T3704 T3693 prep in,examined
R2173 T3705 T3706 nmod Crx,retinas
R2174 T3706 T3704 pobj retinas,in
R2175 T3707 T3705 punct -,Crx
R2176 T3708 T3705 punct /,Crx
R2177 T3709 T3705 punct -,Crx
R2178 T3710 T3693 punct .,examined
R2179 T3712 T3713 prep In,were
R2180 T3714 T3715 nmod Crx,retinas
R2181 T3715 T3712 pobj retinas,In
R2182 T3716 T3714 punct +,Crx
R2183 T3717 T3714 punct /,Crx
R2184 T3718 T3714 punct +,Crx
R2185 T3719 T3713 prep at,were
R2186 T3720 T3719 pobj P21,at
R2187 T3721 T3713 punct ", ",were
R2188 T3722 T3723 advmod newly,mature
R2189 T3723 T3724 amod mature,spherules
R2190 T3724 T3713 nsubj spherules,were
R2191 T3725 T3724 compound rod,spherules
R2192 T3726 T3713 acomp abundant,were
R2193 T3727 T3728 punct (,7A
R2194 T3728 T3713 parataxis 7A,were
R2195 T3729 T3728 compound Figure,7A
R2196 T3730 T3728 punct ),7A
R2197 T3731 T3713 punct .,were
R2198 T3733 T3734 det The,sperules
R2199 T3734 T3735 nsubj sperules,were
R2200 T3736 T3737 amod blunt,structures
R2201 T3737 T3735 attr structures,were
R2202 T3738 T3736 cc or,blunt
R2203 T3739 T3740 npadvmod club,shaped
R2204 T3740 T3736 conj shaped,blunt
R2205 T3741 T3740 punct -,shaped
R2206 T3742 T3737 prep with,structures
R2207 T3743 T3744 det a,ribbon
R2208 T3744 T3742 pobj ribbon,with
R2209 T3745 T3744 amod single,ribbon
R2210 T3746 T3744 acl associated,ribbon
R2211 T3747 T3746 prep with,associated
R2212 T3748 T3749 det a,synapse
R2213 T3749 T3747 pobj synapse,with
R2214 T3750 T3749 amod single,synapse
R2215 T3751 T3749 amod invaginating,synapse
R2216 T3752 T3753 punct (,8A
R2217 T3753 T3735 parataxis 8A,were
R2218 T3754 T3755 compound Figure,7A
R2219 T3755 T3753 dep 7A,8A
R2220 T3756 T3753 punct ", ",8A
R2221 T3757 T3758 nsubj arrow,indicates
R2222 T3758 T3753 ccomp indicates,8A
R2223 T3759 T3760 nummod one,example
R2224 T3760 T3758 dobj example,indicates
R2225 T3761 T3753 punct ;,8A
R2226 T3762 T3753 compound Figure,8A
R2227 T3763 T3753 cc and,8A
R2228 T3764 T3753 conj 8B,8A
R2229 T3765 T3753 punct ),8A
R2230 T3766 T3735 punct .,were
R2231 T3768 T3769 nummod Two,processes
R2232 T3769 T3770 nsubjpass processes,situated
R2233 T3771 T3769 prep from,processes
R2234 T3772 T3773 amod horizontal,cells
R2235 T3773 T3771 pobj cells,from
R2236 T3774 T3770 auxpass were,situated
R2237 T3775 T3770 prep on,situated
R2238 T3776 T3777 det either,side
R2239 T3777 T3775 pobj side,on
R2240 T3778 T3777 prep of,side
R2241 T3779 T3780 det the,ridge
R2242 T3780 T3778 pobj ridge,of
R2243 T3781 T3780 amod synaptic,ridge
R2244 T3782 T3783 punct (,8B
R2245 T3783 T3770 parataxis 8B,situated
R2246 T3784 T3783 compound Figure,8B
R2247 T3785 T3783 punct ", ",8B
R2248 T3786 T3783 advcl labelled,8B
R2249 T3787 T3786 ccomp H,labelled
R2250 T3788 T3783 punct ),8B
R2251 T3789 T3770 cc and,situated
R2252 T3790 T3791 nummod one,dendrites
R2253 T3791 T3794 nsubj dendrites,occupied
R2254 T3792 T3790 cc or,one
R2255 T3793 T3790 conj more,one
R2256 T3794 T3770 conj occupied,situated
R2257 T3795 T3791 prep of,dendrites
R2258 T3796 T3797 nmod rod,cells
R2259 T3797 T3795 pobj cells,of
R2260 T3798 T3797 amod bipolar,cells
R2261 T3799 T3800 det a,position
R2262 T3800 T3794 dobj position,occupied
R2263 T3801 T3800 amod central,position
R2264 T3802 T3803 punct (,B
R2265 T3803 T3794 parataxis B,occupied
R2266 T3804 T3805 compound Figure,8B
R2267 T3805 T3803 dep 8B,B
R2268 T3806 T3803 punct ", ",B
R2269 T3807 T3808 amod bipolar,labelled
R2270 T3808 T3803 amod labelled,B
R2271 T3809 T3794 punct ),occupied
R2272 T3810 T3794 punct .,occupied
R2273 T3812 T3813 compound Cone,terminals
R2274 T3813 T3814 nsubj terminals,are
R2275 T3815 T3816 amod large,flat
R2276 T3816 T3818 amod flat,pedicles
R2277 T3817 T3816 punct ", ",flat
R2278 T3818 T3814 attr pedicles,are
R2279 T3819 T3820 dep that,exhibit
R2280 T3820 T3818 relcl exhibit,pedicles
R2281 T3821 T3822 amod many,synapses
R2282 T3822 T3820 dobj synapses,exhibit
R2283 T3823 T3822 amod invaginating,synapses
R2284 T3824 T3822 acl containing,synapses
R2285 T3825 T3826 amod separate,sets
R2286 T3826 T3824 dobj sets,containing
R2287 T3827 T3826 prep of,sets
R2288 T3828 T3829 amod horizontal,processes
R2289 T3829 T3827 pobj processes,of
R2290 T3830 T3828 cc and,horizontal
R2291 T3831 T3828 conj bipolar,horizontal
R2292 T3832 T3829 compound cell,processes
R2293 T3833 T3814 punct .,are
R2294 T3835 T3836 det Each,pedicle
R2295 T3836 T3837 nsubj pedicle,contains
R2296 T3838 T3839 amod numerous,ribbons
R2297 T3839 T3837 dobj ribbons,contains
R2298 T3840 T3837 punct .,contains
R2299 T3842 T3843 det These,terminals
R2300 T3843 T3844 nsubj terminals,were
R2301 T3845 T3846 advmod much,less
R2302 T3846 T3847 advmod less,common
R2303 T3847 T3844 acomp common,were
R2304 T3848 T3847 prep than,common
R2305 T3849 T3848 pobj spherules,than
R2306 T3850 T3849 prep in,spherules
R2307 T3851 T3852 nmod Crx,retinas
R2308 T3852 T3850 pobj retinas,in
R2309 T3853 T3851 punct +,Crx
R2310 T3854 T3851 punct /,Crx
R2311 T3855 T3851 punct +,Crx
R2312 T3856 T3849 prep at,spherules
R2313 T3857 T3856 pobj P21,at
R2314 T3858 T3859 punct (,box
R2315 T3859 T3844 parataxis box,were
R2316 T3860 T3859 dep Figure,box
R2317 T3861 T3860 nummod 7,Figure
R2318 T3862 T3859 punct ", ",box
R2319 T3863 T3859 punct ),box
R2320 T3864 T3844 punct .,were
R2321 T3866 T3867 prep In,were
R2322 T3868 T3869 det the,OPL
R2323 T3869 T3866 pobj OPL,In
R2324 T3870 T3869 prep of,OPL
R2325 T3871 T3872 nmod Crx,retinas
R2326 T3872 T3870 pobj retinas,of
R2327 T3873 T3871 punct -,Crx
R2328 T3874 T3871 punct /,Crx
R2329 T3875 T3871 punct -,Crx
R2330 T3876 T3867 punct ", ",were
R2331 T3877 T3878 compound photoreceptor,terminals
R2332 T3878 T3867 nsubj terminals,were
R2333 T3879 T3880 advmod highly,disorganized
R2334 T3880 T3867 acomp disorganized,were
R2335 T3881 T3867 prep at,were
R2336 T3882 T3881 pobj P21,at
R2337 T3883 T3884 punct (,arrows
R2338 T3884 T3867 parataxis arrows,were
R2339 T3885 T3886 compound Figure,7B
R2340 T3886 T3884 dep 7B,arrows
R2341 T3887 T3884 punct ", ",arrows
R2342 T3888 T3884 punct ),arrows
R2343 T3889 T3867 punct .,were
R2344 T3891 T3892 nsubj Processes,were
R2345 T3893 T3891 acl containing,Processes
R2346 T3894 T3895 amod synaptic,vesicles
R2347 T3895 T3893 dobj vesicles,containing
R2348 T3896 T3895 cc and,vesicles
R2349 T3897 T3898 npadvmod ribbon,like
R2350 T3898 T3900 amod like,structures
R2351 T3899 T3898 punct -,like
R2352 T3900 T3895 conj structures,vesicles
R2353 T3901 T3892 acomp apparent,were
R2354 T3902 T3892 punct ", ",were
R2355 T3903 T3892 advcl suggesting,were
R2356 T3904 T3905 advmod at,least
R2357 T3905 T3906 advmod least,limited
R2358 T3906 T3907 amod limited,generation
R2359 T3907 T3903 dobj generation,suggesting
R2360 T3908 T3907 prep of,generation
R2361 T3909 T3910 compound synapse,components
R2362 T3910 T3908 pobj components,of
R2363 T3911 T3892 punct .,were
R2364 T3913 T3914 advmod However,observed
R2365 T3915 T3914 punct ", ",observed
R2366 T3916 T3917 advmod well,formed
R2367 T3917 T3918 amod formed,spherules
R2368 T3918 T3914 nsubjpass spherules,observed
R2369 T3919 T3918 cc and,spherules
R2370 T3920 T3918 conj pedicles,spherules
R2371 T3921 T3914 auxpass were,observed
R2372 T3922 T3914 neg not,observed
R2373 T3923 T3914 punct .,observed
R2374 T3925 T3926 prep In,appeared
R2375 T3927 T3925 pobj addition,In
R2376 T3928 T3926 punct ", ",appeared
R2377 T3929 T3930 amod many,terminals
R2378 T3930 T3926 nsubj terminals,appeared
R2379 T3931 T3932 aux to,contain
R2380 T3932 T3926 xcomp contain,appeared
R2381 T3933 T3934 amod multiple,ribbons
R2382 T3934 T3932 dobj ribbons,contain
R2383 T3935 T3936 punct (,r
R2384 T3936 T3934 parataxis r,ribbons
R2385 T3937 T3938 compound Figure,8C
R2386 T3938 T3936 dep 8C,r
R2387 T3939 T3938 cc and,8C
R2388 T3940 T3938 conj 8D,8C
R2389 T3941 T3936 punct ", ",r
R2390 T3942 T3936 punct ),r
R2391 T3943 T3944 neg not,tethered
R2392 T3944 T3934 acl tethered,ribbons
R2393 T3945 T3944 prep to,tethered
R2394 T3946 T3947 det the,membrane
R2395 T3947 T3945 pobj membrane,to
R2396 T3948 T3947 compound plasma,membrane
R2397 T3949 T3944 cc and,tethered
R2398 T3950 T3951 advmod occasionally,in
R2399 T3951 T3944 conj in,tethered
R2400 T3952 T3953 amod perinuclear,positions
R2401 T3953 T3951 pobj positions,in
R2402 T3954 T3955 punct (,8D
R2403 T3955 T3932 parataxis 8D,contain
R2404 T3956 T3955 compound Figure,8D
R2405 T3957 T3955 punct ),8D
R2406 T3958 T3926 punct .,appeared
R2407 T4008 T4009 prep In,carried
R2408 T4010 T4011 det this,study
R2409 T4011 T4008 pobj study,In
R2410 T4012 T4009 punct ", ",carried
R2411 T4013 T4014 det an,analysis
R2412 T4014 T4009 nsubjpass analysis,carried
R2413 T4015 T4014 amod ultrastructural,analysis
R2414 T4016 T4014 prep of,analysis
R2415 T4017 T4018 nmod Crx,photoreceptors
R2416 T4018 T4016 pobj photoreceptors,of
R2417 T4019 T4017 punct -,Crx
R2418 T4020 T4017 punct /,Crx
R2419 T4021 T4017 punct -,Crx
R2420 T4022 T4009 auxpass was,carried
R2421 T4023 T4009 prt out,carried
R2422 T4024 T4009 punct .,carried
R2423 T4026 T4027 mark As,associated
R2424 T4027 T4032 advcl associated,broaden
R2425 T4028 T4029 compound Crx,mutations
R2426 T4029 T4027 nsubjpass mutations,associated
R2427 T4030 T4027 aux have,associated
R2428 T4031 T4027 auxpass been,associated
R2429 T4033 T4027 prep with,associated
R2430 T4034 T4035 poss Leber,amaurosis
R2431 T4035 T4033 pobj amaurosis,with
R2432 T4036 T4034 case 's,Leber
R2433 T4037 T4035 amod congenital,amaurosis
R2434 T4038 T4032 punct ", ",broaden
R2435 T4039 T4040 det the,findings
R2436 T4040 T4032 nsubj findings,broaden
R2437 T4041 T4040 prep in,findings
R2438 T4042 T4043 det this,study
R2439 T4043 T4041 pobj study,in
R2440 T4044 T4045 poss our,understanding
R2441 T4045 T4032 dobj understanding,broaden
R2442 T4046 T4045 prep of,understanding
R2443 T4047 T4048 det the,pathology
R2444 T4048 T4046 pobj pathology,of
R2445 T4049 T4048 prep of,pathology
R2446 T4050 T4051 det this,disease
R2447 T4051 T4049 pobj disease,of
R2448 T4052 T4032 punct .,broaden
R2449 T4054 T4055 nummod Two,pathologies
R2450 T4055 T4057 nsubjpass pathologies,characterized
R2451 T4056 T4055 amod prominent,pathologies
R2452 T4057 T4059 ccomp characterized,exhibited
R2453 T4058 T4057 auxpass were,characterized
R2454 T4060 T4057 prep in,characterized
R2455 T4061 T4062 det the,retina
R2456 T4062 T4060 pobj retina,in
R2457 T4063 T4062 nmod Crx,retina
R2458 T4064 T4063 punct -,Crx
R2459 T4065 T4063 punct /,Crx
R2460 T4066 T4063 punct -,Crx
R2461 T4067 T4059 punct : ,exhibited
R2462 T4068 T4069 punct (,1
R2463 T4069 T4070 meta 1,noted
R2464 T4070 T4059 ccomp noted,exhibited
R2465 T4071 T4069 punct ),1
R2466 T4072 T4073 det An,block
R2467 T4073 T4070 nsubjpass block,noted
R2468 T4074 T4073 amod absolute,block
R2469 T4075 T4073 prep in,block
R2470 T4076 T4077 amod outer,segment
R2471 T4077 T4078 compound segment,morphogenesis
R2472 T4078 T4075 pobj morphogenesis,in
R2473 T4079 T4070 auxpass was,noted
R2474 T4080 T4070 punct ", ",noted
R2475 T4081 T4070 prep with,noted
R2476 T4082 T4083 det the,block
R2477 T4083 T4084 nsubj block,occuring
R2478 T4084 T4081 pcomp occuring,with
R2479 T4085 T4084 prep at,occuring
R2480 T4086 T4087 det the,stage
R2481 T4087 T4085 pobj stage,at
R2482 T4088 T4087 compound elongation,stage
R2483 T4089 T4087 prep of,stage
R2484 T4090 T4091 amod outer,segment
R2485 T4091 T4092 compound segment,formation
R2486 T4092 T4089 pobj formation,of
R2487 T4093 T4059 punct ;,exhibited
R2488 T4094 T4095 punct (,2
R2489 T4095 T4059 meta 2,exhibited
R2490 T4096 T4095 punct ),2
R2491 T4097 T4098 nmod Crx,photoreceptors
R2492 T4098 T4059 nsubj photoreceptors,exhibited
R2493 T4099 T4097 punct -,Crx
R2494 T4100 T4097 punct /,Crx
R2495 T4101 T4097 punct -,Crx
R2496 T4102 T4103 det a,perturbation
R2497 T4103 T4059 dobj perturbation,exhibited
R2498 T4104 T4103 amod severe,perturbation
R2499 T4105 T4103 prep in,perturbation
R2500 T4106 T4107 compound synapse,formation
R2501 T4107 T4105 pobj formation,in
R2502 T4108 T4059 punct .,exhibited
R2503 T4110 T4111 nsubj This,represents
R2504 T4112 T4113 det the,report
R2505 T4113 T4111 dobj report,represents
R2506 T4114 T4113 amod first,report
R2507 T4115 T4113 prep of,report
R2508 T4116 T4117 det a,defect
R2509 T4117 T4115 pobj defect,of
R2510 T4118 T4117 compound synaptogenesis,defect
R2511 T4119 T4117 prep in,defect
R2512 T4120 T4121 det an,model
R2513 T4121 T4119 pobj model,in
R2514 T4122 T4121 compound animal,model
R2515 T4123 T4121 prep of,model
R2516 T4124 T4123 pobj LCA,of
R2517 T4125 T4111 punct .,represents
R2524 T4696 T4697 nmod Crx,photoreceptors
R2525 T4697 T4701 nsubj photoreceptors,complete
R2526 T4698 T4696 punct -,Crx
R2527 T4699 T4696 punct /,Crx
R2528 T4700 T4696 punct -,Crx
R2529 T4702 T4701 aux can,complete
R2530 T4703 T4701 neg not,complete
R2531 T4704 T4705 amod outer,segment
R2532 T4705 T4706 compound segment,morphogenesis
R2533 T4706 T4701 dobj morphogenesis,complete
R2534 T4708 T4709 nsubj Mutations,represent
R2535 T4710 T4708 prep in,Mutations
R2536 T4711 T4710 pobj Crx,in
R2537 T4712 T4709 dobj one,represent
R2538 T4713 T4712 prep of,one
R2539 T4714 T4715 det a,collection
R2540 T4715 T4713 pobj collection,of
R2541 T4716 T4715 prep of,collection
R2542 T4717 T4718 compound gene,mutations
R2543 T4718 T4716 pobj mutations,of
R2544 T4719 T4720 dep that,lead
R2545 T4720 T4718 relcl lead,mutations
R2546 T4721 T4720 prep to,lead
R2547 T4722 T4723 det an,defect
R2548 T4723 T4721 pobj defect,to
R2549 T4724 T4725 amod outer,segment
R2550 T4725 T4723 compound segment,defect
R2551 T4726 T4723 compound formation,defect
R2552 T4727 T4709 punct .,represent
R2553 T4729 T4730 amod Homozygous,mutations
R2554 T4730 T4732 nsubj mutations,lead
R2555 T4731 T4730 amod null,mutations
R2556 T4733 T4730 prep in,mutations
R2557 T4734 T4735 det the,gene
R2558 T4735 T4733 pobj gene,in
R2559 T4736 T4737 compound peripherin,RDS
R2560 T4737 T4735 compound RDS,gene
R2561 T4738 T4737 punct /,RDS
R2562 T4739 T4740 punct [,36
R2563 T4740 T4735 parataxis 36,gene
R2564 T4741 T4740 punct ],36
R2565 T4742 T4733 cc or,in
R2566 T4743 T4733 conj in,in
R2567 T4744 T4743 pobj rhodopsin,in
R2568 T4745 T4746 punct [,29
R2569 T4746 T4744 parataxis 29,rhodopsin
R2570 T4747 T4746 punct ],29
R2571 T4748 T4732 prep to,lead
R2572 T4749 T4750 det a,failure
R2573 T4750 T4748 pobj failure,to
R2574 T4751 T4750 prep of,failure
R2575 T4752 T4753 amod outer,segment
R2576 T4753 T4754 compound segment,formation
R2577 T4754 T4751 pobj formation,of
R2578 T4755 T4732 punct .,lead
R2579 T4757 T4758 det The,deficits
R2580 T4758 T4759 nsubjpass deficits,found
R2581 T4760 T4758 prep in,deficits
R2582 T4761 T4762 nmod peripherin,morphogenesis
R2583 T4762 T4760 pobj morphogenesis,in
R2584 T4763 T4761 punct -,peripherin
R2585 T4764 T4761 punct /,peripherin
R2586 T4765 T4761 punct -,peripherin
R2587 T4766 T4761 cc and,peripherin
R2588 T4767 T4761 conj Crx,peripherin
R2589 T4768 T4767 punct -,Crx
R2590 T4769 T4767 punct /,Crx
R2591 T4770 T4767 punct -,Crx
R2592 T4771 T4762 compound photoreceptor,morphogenesis
R2593 T4772 T4759 auxpass were,found
R2594 T4773 T4774 aux to,be
R2595 T4774 T4759 xcomp be,found
R2596 T4775 T4776 advmod very,similar
R2597 T4776 T4774 acomp similar,be
R2598 T4777 T4759 punct .,found
R2599 T4779 T4780 amod Vesicular,structures
R2600 T4780 T4781 nsubjpass structures,observed
R2601 T4782 T4780 prep in,structures
R2602 T4783 T4784 nmod Crx,photoreceptors
R2603 T4784 T4782 pobj photoreceptors,in
R2604 T4785 T4783 punct -,Crx
R2605 T4786 T4783 punct /,Crx
R2606 T4787 T4783 punct -,Crx
R2607 T4788 T4781 auxpass were,observed
R2608 T4789 T4790 dep that,were
R2609 T4790 T4781 ccomp were,observed
R2610 T4791 T4790 acomp similar,were
R2611 T4792 T4791 prep to,similar
R2612 T4793 T4792 pobj those,to
R2613 T4794 T4795 advmod previously,noted
R2614 T4795 T4793 acl noted,those
R2615 T4796 T4795 prep in,noted
R2616 T4797 T4798 det the,mouse
R2617 T4798 T4796 pobj mouse,in
R2618 T4799 T4800 nmod rds,peripherin
R2619 T4800 T4798 nmod peripherin,mouse
R2620 T4801 T4800 punct /,peripherin
R2621 T4802 T4800 punct -,peripherin
R2622 T4803 T4800 punct /,peripherin
R2623 T4804 T4800 punct -,peripherin
R2624 T4805 T4781 punct .,observed
R2625 T4807 T4808 nsubjpass It,proposed
R2626 T4809 T4808 auxpass was,proposed
R2627 T4810 T4808 advmod initially,proposed
R2628 T4811 T4812 mark that,were
R2629 T4812 T4808 ccomp were,proposed
R2630 T4813 T4814 det these,vesicles
R2631 T4814 T4812 nsubj vesicles,were
R2632 T4815 T4812 prep due,were
R2633 T4816 T4815 pcomp to,due
R2634 T4817 T4818 det the,breakdown
R2635 T4818 T4815 pobj breakdown,due
R2636 T4819 T4818 prep of,breakdown
R2637 T4820 T4821 amod outer,segment
R2638 T4821 T4822 compound segment,membranes
R2639 T4822 T4819 pobj membranes,of
R2640 T4823 T4824 dep that,recruited
R2641 T4824 T4822 relcl recruited,membranes
R2642 T4825 T4824 auxpass were,recruited
R2643 T4826 T4824 neg not,recruited
R2644 T4827 T4824 advmod properly,recruited
R2645 T4828 T4824 prep to,recruited
R2646 T4829 T4830 det the,segments
R2647 T4830 T4828 pobj segments,to
R2648 T4831 T4830 amod outer,segments
R2649 T4832 T4824 prep in,recruited
R2650 T4833 T4834 det the,absence
R2651 T4834 T4832 pobj absence,in
R2652 T4835 T4834 prep of,absence
R2653 T4836 T4835 pobj peripherin,of
R2654 T4837 T4812 punct ", ",were
R2655 T4838 T4812 cc or,were
R2656 T4839 T4812 conj were,were
R2657 T4840 T4839 prep from,were
R2658 T4841 T4842 det the,result
R2659 T4842 T4840 pobj result,from
R2660 T4843 T4842 prep of,result
R2661 T4844 T4845 det the,breakdown
R2662 T4845 T4843 pobj breakdown,of
R2663 T4846 T4845 prep of,breakdown
R2664 T4847 T4848 det the,microvilli
R2665 T4848 T4846 pobj microvilli,of
R2666 T4849 T4848 prep of,microvilli
R2667 T4850 T4851 compound Müller,cells
R2668 T4851 T4849 pobj cells,of
R2669 T4852 T4853 punct [,30
R2670 T4853 T4839 parataxis 30,were
R2671 T4854 T4853 punct ],30
R2672 T4855 T4808 punct .,proposed
R2673 T4857 T4858 amod Strong,support
R2674 T4858 T4859 nsubjpass support,provided
R2675 T4860 T4858 prep in,support
R2676 T4861 T4860 pobj favor,in
R2677 T4862 T4861 prep of,favor
R2678 T4863 T4864 det the,explanation
R2679 T4864 T4862 pobj explanation,of
R2680 T4865 T4864 amod former,explanation
R2681 T4866 T4859 auxpass was,provided
R2682 T4867 T4859 agent by,provided
R2683 T4868 T4867 pobj Nir,by
R2684 T4869 T4868 cc and,Nir
R2685 T4870 T4868 conj colleagues,Nir
R2686 T4871 T4872 dep who,demonstrated
R2687 T4872 T4868 relcl demonstrated,Nir
R2688 T4873 T4874 det the,presence
R2689 T4874 T4872 dobj presence,demonstrated
R2690 T4875 T4874 prep of,presence
R2691 T4876 T4877 compound rhodopsin,protein
R2692 T4877 T4875 pobj protein,of
R2693 T4878 T4874 prep in,presence
R2694 T4879 T4880 det these,vesicles
R2695 T4880 T4878 pobj vesicles,in
R2696 T4881 T4872 advcl using,demonstrated
R2697 T4882 T4883 compound immunoelectron,microscopy
R2698 T4883 T4881 dobj microscopy,using
R2699 T4884 T4881 prep against,using
R2700 T4885 T4886 det a,epitope
R2701 T4886 T4884 pobj epitope,against
R2702 T4887 T4886 compound rhodopsin,epitope
R2703 T4888 T4889 punct [,37
R2704 T4889 T4872 parataxis 37,demonstrated
R2705 T4890 T4889 punct ],37
R2706 T4891 T4859 punct .,provided
R2707 T4893 T4894 advmod Further,appear
R2708 T4895 T4894 punct ", ",appear
R2709 T4896 T4897 mark as,shown
R2710 T4897 T4894 advcl shown,appear
R2711 T4898 T4897 advmod here,shown
R2712 T4899 T4894 punct ", ",appear
R2713 T4900 T4901 det the,vesicles
R2714 T4901 T4894 nsubj vesicles,appear
R2715 T4902 T4903 aux to,bud
R2716 T4903 T4894 xcomp bud,appear
R2717 T4904 T4903 prep from,bud
R2718 T4905 T4906 det the,segments
R2719 T4906 T4904 pobj segments,from
R2720 T4907 T4906 amod inner,segments
R2721 T4908 T4906 appos themselves,segments
R2722 T4909 T4894 punct .,appear
R2723 T4911 T4912 prep In,occurs
R2724 T4913 T4914 amod developing,photoreceptors
R2725 T4914 T4911 pobj photoreceptors,In
R2726 T4915 T4912 punct ", ",occurs
R2727 T4916 T4917 det an,process
R2728 T4917 T4912 nsubj process,occurs
R2729 T4918 T4917 amod extraordinary,process
R2730 T4919 T4917 compound growth,process
R2731 T4920 T4921 advmod whereby,generated
R2732 T4921 T4912 ccomp generated,occurs
R2733 T4922 T4923 det the,segment
R2734 T4923 T4921 nsubjpass segment,generated
R2735 T4924 T4923 amod outer,segment
R2736 T4925 T4921 auxpass is,generated
R2737 T4926 T4921 prep from,generated
R2738 T4927 T4928 det the,cilium
R2739 T4928 T4926 pobj cilium,from
R2740 T4929 T4928 amod nascent,cilium
R2741 T4930 T4928 amod connecting,cilium
R2742 T4931 T4932 punct (,see
R2743 T4932 T4912 parataxis see,occurs
R2744 T4933 T4934 punct [,38
R2745 T4934 T4932 dobj 38,see
R2746 T4935 T4934 punct ],38
R2747 T4936 T4934 cc and,38
R2748 T4937 T4934 conj references,38
R2749 T4938 T4937 advmod therein,references
R2750 T4939 T4932 punct ),see
R2751 T4940 T4912 punct .,occurs
R2752 T4942 T4943 nmod Peripherin,RDS
R2753 T4943 T4945 nmod RDS,proteins
R2754 T4944 T4943 punct /,RDS
R2755 T4945 T4950 nsubj proteins,have
R2756 T4946 T4943 cc and,RDS
R2757 T4947 T4943 conj ROM,RDS
R2758 T4948 T4947 punct -,ROM
R2759 T4949 T4947 nummod 1,ROM
R2760 T4951 T4945 punct (,proteins
R2761 T4952 T4945 acl localized,proteins
R2762 T4953 T4952 prep in,localized
R2763 T4954 T4955 compound disc,rims
R2764 T4955 T4953 pobj rims,in
R2765 T4956 T4945 punct ),proteins
R2766 T4957 T4945 cc and,proteins
R2767 T4958 T4959 det the,proteins
R2768 T4959 T4945 conj proteins,proteins
R2769 T4960 T4959 compound opsin,proteins
R2770 T4961 T4959 punct (,proteins
R2771 T4962 T4959 acl localized,proteins
R2772 T4963 T4962 prep throughout,localized
R2773 T4964 T4965 det the,discs
R2774 T4965 T4963 pobj discs,throughout
R2775 T4966 T4950 punct ),have
R2776 T4967 T4968 amod important,roles
R2777 T4968 T4950 dobj roles,have
R2778 T4969 T4968 prep in,roles
R2779 T4970 T4971 det the,integrity
R2780 T4971 T4969 pobj integrity,in
R2781 T4972 T4971 amod structural,integrity
R2782 T4973 T4971 prep of,integrity
R2783 T4974 T4975 amod mature,segments
R2784 T4975 T4973 pobj segments,of
R2785 T4976 T4975 amod outer,segments
R2786 T4977 T4978 punct (,see
R2787 T4978 T4950 parataxis see,have
R2788 T4979 T4978 punct [,see
R2789 T4980 T4981 nummod 39,29
R2790 T4981 T4978 dobj 29,see
R2791 T4982 T4981 punct ",",29
R2792 T4983 T4978 punct ],see
R2793 T4984 T4978 punct ),see
R2794 T4985 T4950 punct .,have
R2795 T4987 T4988 nmod ROM,mice
R2796 T4988 T4994 nsubj mice,produce
R2797 T4989 T4987 punct -,ROM
R2798 T4990 T4987 nummod 1,ROM
R2799 T4991 T4987 punct -,ROM
R2800 T4992 T4987 punct /,ROM
R2801 T4993 T4987 punct -,ROM
R2802 T4995 T4996 amod disorganized,segments
R2803 T4996 T4994 dobj segments,produce
R2804 T4997 T4996 amod outer,segments
R2805 T4998 T4996 prep with,segments
R2806 T4999 T5000 amod large,disks
R2807 T5000 T4998 pobj disks,with
R2808 T5001 T5002 punct [,40
R2809 T5002 T4994 parataxis 40,produce
R2810 T5003 T5002 punct ],40
R2811 T5004 T4994 punct .,produce
R2812 T5006 T5007 nsubj Crx,controls
R2813 T5008 T5007 punct ", ",controls
R2814 T5009 T5007 prep by,controls
R2815 T5010 T5009 pobj virtue,by
R2816 T5011 T5010 prep of,virtue
R2817 T5012 T5011 pcomp being,of
R2818 T5013 T5014 det a,factor
R2819 T5014 T5012 attr factor,being
R2820 T5015 T5014 compound transcription,factor
R2821 T5016 T5007 punct ", ",controls
R2822 T5017 T5007 advmod presumably,controls
R2823 T5018 T5007 dobj genes,controls
R2824 T5019 T5020 dep that,are
R2825 T5020 T5018 relcl are,genes
R2826 T5021 T5020 acomp responsible,are
R2827 T5022 T5021 prep for,responsible
R2828 T5023 T5024 det the,building
R2829 T5024 T5022 pobj building,for
R2830 T5025 T5024 cc and,building
R2831 T5026 T5027 advmod perhaps,maintenance
R2832 T5027 T5024 conj maintenance,building
R2833 T5028 T5024 prep of,building
R2834 T5029 T5030 det the,structure
R2835 T5030 T5028 pobj structure,of
R2836 T5031 T5032 amod outer,segment
R2837 T5032 T5030 compound segment,structure
R2838 T5033 T5018 punct ", ",genes
R2839 T5034 T5018 prep including,genes
R2840 T5035 T5034 pobj rhodopsin,including
R2841 T5036 T5035 cc and,rhodopsin
R2842 T5037 T5035 conj peripherin,rhodopsin
R2843 T5038 T5007 punct .,controls
R2844 T5040 T5041 advcl Using,defined
R2845 T5042 T5043 compound northern,blots
R2846 T5043 T5040 dobj blots,Using
R2847 T5044 T5045 punct [,34
R2848 T5045 T5043 parataxis 34,blots
R2849 T5046 T5045 punct ],34
R2850 T5047 T5043 punct ", ",blots
R2851 T5048 T5043 conj microarrays,blots
R2852 T5049 T5050 punct [,10
R2853 T5050 T5048 parataxis 10,microarrays
R2854 T5051 T5050 punct ],10
R2855 T5052 T5048 punct ", ",microarrays
R2856 T5053 T5048 cc and,microarrays
R2857 T5054 T5055 amod serial,analysis
R2858 T5055 T5048 conj analysis,microarrays
R2859 T5056 T5055 prep of,analysis
R2860 T5057 T5058 compound gene,expression
R2861 T5058 T5056 pobj expression,of
R2862 T5059 T5055 punct (,analysis
R2863 T5060 T5055 appos SAGE,analysis
R2864 T5061 T5055 punct ),analysis
R2865 T5062 T5063 punct [,35
R2866 T5063 T5055 parataxis 35,analysis
R2867 T5064 T5063 punct ],35
R2868 T5065 T5041 punct ", ",defined
R2869 T5066 T5041 nsubj we,defined
R2870 T5067 T5041 aux have,defined
R2871 T5068 T5069 det a,number
R2872 T5069 T5041 dobj number,defined
R2873 T5070 T5069 amod large,number
R2874 T5071 T5069 prep of,number
R2875 T5072 T5071 pobj genes,of
R2876 T5073 T5074 dep that,altered
R2877 T5074 T5072 relcl altered,genes
R2878 T5075 T5074 auxpass are,altered
R2879 T5076 T5074 prep in,altered
R2880 T5077 T5078 poss their,level
R2881 T5078 T5076 pobj level,in
R2882 T5079 T5078 compound expression,level
R2883 T5080 T5074 prep in,altered
R2884 T5081 T5082 nmod Crx,mice
R2885 T5082 T5080 pobj mice,in
R2886 T5083 T5081 punct -,Crx
R2887 T5084 T5081 punct /,Crx
R2888 T5085 T5081 punct -,Crx
R2889 T5086 T5041 punct .,defined
R2890 T5088 T5089 nsubj We,found
R2891 T5090 T5091 mark that,diminished
R2892 T5091 T5089 ccomp diminished,found
R2893 T5092 T5093 compound rhodopsin,expression
R2894 T5093 T5091 nsubjpass expression,diminished
R2895 T5094 T5091 auxpass was,diminished
R2896 T5095 T5091 advmod severely,diminished
R2897 T5096 T5091 prep in,diminished
R2898 T5097 T5098 nmod Crx,animals
R2899 T5098 T5096 pobj animals,in
R2900 T5099 T5097 punct -,Crx
R2901 T5100 T5097 punct /,Crx
R2902 T5101 T5097 punct -,Crx
R2903 T5102 T5091 punct ", ",diminished
R2904 T5103 T5091 cc and,diminished
R2905 T5104 T5105 compound peripherin,mRNA
R2906 T5105 T5106 nsubjpass mRNA,reduced
R2907 T5106 T5091 conj reduced,diminished
R2908 T5107 T5106 auxpass was,reduced
R2909 T5108 T5106 prep by,reduced
R2910 T5109 T5110 advmod approximately,30
R2911 T5110 T5111 nummod 30,%
R2912 T5111 T5108 pobj %,by
R2913 T5112 T5089 punct .,found
R2914 T5114 T5115 amod Transgenic,mice
R2915 T5115 T5116 nsubj mice,exhibit
R2916 T5117 T5115 prep with,mice
R2917 T5118 T5119 amod variable,levels
R2918 T5119 T5117 pobj levels,with
R2919 T5120 T5119 prep of,levels
R2920 T5121 T5120 pobj expression,of
R2921 T5122 T5121 prep of,expression
R2922 T5123 T5124 amod wild,type
R2923 T5124 T5125 compound type,rhodopsin
R2924 T5125 T5122 pobj rhodopsin,of
R2925 T5126 T5127 compound rod,degeneration
R2926 T5127 T5116 dobj degeneration,exhibit
R2927 T5128 T5129 punct [,41
R2928 T5129 T5116 parataxis 41,exhibit
R2929 T5130 T5129 punct ],41
R2930 T5131 T5116 punct ", ",exhibit
R2931 T5132 T5116 advcl indicating,exhibit
R2932 T5133 T5134 det the,importance
R2933 T5134 T5132 dobj importance,indicating
R2934 T5135 T5134 prep of,importance
R2935 T5136 T5137 det the,level
R2936 T5137 T5135 pobj level,of
R2937 T5138 T5137 prep of,level
R2938 T5139 T5140 compound rhodopsin,expression
R2939 T5140 T5138 pobj expression,of
R2940 T5141 T5116 punct .,exhibit
R2941 T5143 T5144 prep In,be
R2942 T5145 T5143 pobj addition,In
R2943 T5146 T5144 punct ", ",be
R2944 T5147 T5148 det the,timing
R2945 T5148 T5144 nsubj timing,be
R2946 T5149 T5148 prep of,timing
R2947 T5150 T5151 compound rhodopsin,expression
R2948 T5151 T5149 pobj expression,of
R2949 T5152 T5144 aux may,be
R2950 T5153 T5154 advmod very,important
R2951 T5154 T5144 acomp important,be
R2952 T5155 T5144 punct ", ",be
R2953 T5156 T5157 mark as,indicated
R2954 T5157 T5144 advcl indicated,be
R2955 T5158 T5157 agent by,indicated
R2956 T5159 T5158 pobj studies,by
R2957 T5160 T5159 prep in,studies
R2958 T5161 T5160 pobj Drosophila,in
R2959 T5162 T5144 punct .,be
R2960 T5164 T5165 prep In,expressed
R2961 T5166 T5164 pobj Drosophila,In
R2962 T5167 T5165 punct ", ",expressed
R2963 T5168 T5165 nsubjpass rhodopsin,expressed
R2964 T5169 T5170 punct (,ninaE
R2965 T5170 T5168 parataxis ninaE,rhodopsin
R2966 T5171 T5170 punct ),ninaE
R2967 T5172 T5165 auxpass is,expressed
R2968 T5173 T5165 prep in,expressed
R2969 T5174 T5175 compound photoreceptors,R1
R2970 T5175 T5173 pobj R1,in
R2971 T5176 T5177 punct –,R6
R2972 T5177 T5175 prep R6,R1
R2973 T5178 T5165 punct .,expressed
R2974 T5180 T5181 prep In,fails
R2975 T5182 T5183 npadvmod ninaE,null
R2976 T5183 T5184 amod null,mutants
R2977 T5184 T5180 pobj mutants,In
R2978 T5185 T5181 punct ", ",fails
R2979 T5186 T5187 det the,rhabdomere
R2980 T5187 T5181 nsubj rhabdomere,fails
R2981 T5188 T5187 punct ", ",rhabdomere
R2982 T5189 T5190 det a,structure
R2983 T5190 T5187 appos structure,rhabdomere
R2984 T5191 T5190 amod analogous,structure
R2985 T5192 T5191 prep to,analogous
R2986 T5193 T5194 nmod vertebrate,segments
R2987 T5194 T5192 pobj segments,to
R2988 T5195 T5194 amod outer,segments
R2989 T5196 T5181 punct ", ",fails
R2990 T5197 T5198 aux to,develop
R2991 T5198 T5181 xcomp develop,fails
R2992 T5199 T5198 prep in,develop
R2993 T5200 T5201 nmod R1,photoreceptors
R2994 T5201 T5199 pobj photoreceptors,in
R2995 T5202 T5203 punct –,R6
R2996 T5203 T5200 prep R6,R1
R2997 T5204 T5205 punct [,42
R2998 T5205 T5198 parataxis 42,develop
R2999 T5206 T5205 punct ],42
R3000 T5207 T5198 punct ", ",develop
R3001 T5208 T5198 advcl reminiscent,develop
R3002 T5209 T5208 prep of,reminiscent
R3003 T5210 T5211 det the,situation
R3004 T5211 T5209 pobj situation,of
R3005 T5212 T5211 prep in,situation
R3006 T5213 T5214 nmod rhodopsin,mice
R3007 T5214 T5212 pobj mice,in
R3008 T5215 T5213 punct -,rhodopsin
R3009 T5216 T5213 punct /,rhodopsin
R3010 T5217 T5213 punct -,rhodopsin
R3011 T5218 T5219 punct [,29
R3012 T5219 T5208 parataxis 29,reminiscent
R3013 T5220 T5219 punct ],29
R3014 T5221 T5181 punct .,fails
R3015 T5223 T5224 det An,experiment
R3016 T5224 T5226 nsubj experiment,demonstrated
R3017 T5225 T5224 amod intriguing,experiment
R3018 T5227 T5224 prep by,experiment
R3019 T5228 T5227 pobj Kumar,by
R3020 T5229 T5230 advmod et,al.
R3021 T5230 T5228 advmod al.,Kumar
R3022 T5231 T5232 punct [,43
R3023 T5232 T5228 parataxis 43,Kumar
R3024 T5233 T5232 punct ],43
R3025 T5234 T5235 det a,requirement
R3026 T5235 T5226 dobj requirement,demonstrated
R3027 T5236 T5235 amod temporal,requirement
R3028 T5237 T5235 prep for,requirement
R3029 T5238 T5239 compound rhodopsin,expression
R3030 T5239 T5237 pobj expression,for
R3031 T5240 T5235 prep during,requirement
R3032 T5241 T5242 compound rhabdomere,development
R3033 T5242 T5240 pobj development,during
R3034 T5243 T5226 punct .,demonstrated
R3035 T5245 T5246 prep In,subjected
R3036 T5247 T5248 npadvmod ninaE,null
R3037 T5248 T5249 amod null,flies
R3038 T5249 T5245 pobj flies,In
R3039 T5250 T5246 punct ", ",subjected
R3040 T5251 T5252 det a,transgene
R3041 T5252 T5246 nsubjpass transgene,subjected
R3042 T5253 T5252 compound ninaE,transgene
R3043 T5254 T5252 prep under,transgene
R3044 T5255 T5256 det the,control
R3045 T5256 T5254 pobj control,under
R3046 T5257 T5256 prep of,control
R3047 T5258 T5259 det a,promoter
R3048 T5259 T5257 pobj promoter,of
R3049 T5260 T5261 compound heat,shock
R3050 T5261 T5259 compound shock,promoter
R3051 T5262 T5246 auxpass was,subjected
R3052 T5263 T5246 prep to,subjected
R3053 T5264 T5265 amod various,shifts
R3054 T5265 T5263 pobj shifts,to
R3055 T5266 T5265 compound temperature,shifts
R3056 T5267 T5246 prep during,subjected
R3057 T5268 T5267 pobj development,during
R3058 T5269 T5246 punct .,subjected
R3059 T5271 T5272 compound Heat,shock
R3060 T5272 T5273 nsubj shock,resulted
R3061 T5274 T5272 prep during,shock
R3062 T5275 T5276 det the,time
R3063 T5276 T5274 pobj time,during
R3064 T5277 T5276 amod normal,time
R3065 T5278 T5276 prep of,time
R3066 T5279 T5280 compound rhodopsin,onset
R3067 T5280 T5278 pobj onset,of
R3068 T5281 T5273 prep in,resulted
R3069 T5282 T5283 amod substantial,rescue
R3070 T5283 T5281 pobj rescue,in
R3071 T5284 T5282 cc and,substantial
R3072 T5285 T5286 advmod long,lasting
R3073 T5286 T5282 conj lasting,substantial
R3074 T5287 T5286 punct -,lasting
R3075 T5288 T5283 prep of,rescue
R3076 T5289 T5290 compound photoreceptor,structure
R3077 T5290 T5288 pobj structure,of
R3078 T5291 T5283 cc and,rescue
R3079 T5292 T5293 amod transient,rescue
R3080 T5293 T5283 conj rescue,rescue
R3081 T5294 T5293 prep of,rescue
R3082 T5295 T5296 compound photoreceptor,physiology
R3083 T5296 T5294 pobj physiology,of
R3084 T5297 T5273 punct .,resulted
R3085 T5299 T5300 advmod However,failed
R3086 T5301 T5300 punct ", ",failed
R3087 T5302 T5300 nsubj expression,failed
R3088 T5303 T5304 advmod shortly,before
R3089 T5304 T5302 prep before,expression
R3090 T5305 T5304 cc or,before
R3091 T5306 T5304 conj after,before
R3092 T5307 T5308 det this,period
R3093 T5308 T5306 pobj period,after
R3094 T5309 T5308 amod critical,period
R3095 T5310 T5311 aux to,rescue
R3096 T5311 T5300 xcomp rescue,failed
R3097 T5312 T5300 punct ", ",failed
R3098 T5313 T5300 advcl suggesting,failed
R3099 T5314 T5315 mark that,is
R3100 T5315 T5313 ccomp is,suggesting
R3101 T5316 T5317 compound rhodopsin,expression
R3102 T5317 T5315 nsubj expression,is
R3103 T5318 T5317 prep during,expression
R3104 T5319 T5320 det a,window
R3105 T5320 T5318 pobj window,during
R3106 T5321 T5320 amod discrete,window
R3107 T5322 T5320 prep of,window
R3108 T5323 T5322 pobj time,of
R3109 T5324 T5320 prep in,window
R3110 T5325 T5324 pobj development,in
R3111 T5326 T5315 acomp essential,is
R3112 T5327 T5326 prep for,essential
R3113 T5328 T5329 amod proper,morphogenesis
R3114 T5329 T5327 pobj morphogenesis,for
R3115 T5330 T5329 amod rhabdomere,morphogenesis
R3116 T5331 T5300 punct .,failed
R3117 T5333 T5334 det This,result
R3118 T5334 T5335 nsubj result,is
R3119 T5336 T5335 acomp consistent,is
R3120 T5337 T5336 prep with,consistent
R3121 T5338 T5337 pobj observations,with
R3122 T5339 T5338 prep in,observations
R3123 T5340 T5341 det the,rat
R3124 T5341 T5339 pobj rat,in
R3125 T5342 T5343 prep wherein,occurs
R3126 T5343 T5338 relcl occurs,observations
R3127 T5344 T5345 compound rhodopsin,onset
R3128 T5345 T5343 nsubj onset,occurs
R3129 T5346 T5343 prep with,occurs
R3130 T5347 T5348 amod strict,timing
R3131 T5348 T5346 pobj timing,with
R3132 T5349 T5343 prep in,occurs
R3133 T5350 T5351 det the,history
R3134 T5351 T5349 pobj history,in
R3135 T5352 T5351 amod developmental,history
R3136 T5353 T5351 prep of,history
R3137 T5354 T5355 amod most,rods
R3138 T5355 T5353 pobj rods,of
R3139 T5356 T5357 advmod in,vivo
R3140 T5357 T5343 advmod vivo,occurs
R3141 T5358 T5359 punct [,44
R3142 T5359 T5338 parataxis 44,observations
R3143 T5360 T5359 punct ],44
R3144 T5361 T5335 punct .,is
R3145 T5363 T5364 advmod Thus,regulating
R3146 T5365 T5364 punct ", ",regulating
R3147 T5366 T5364 prep through,regulating
R3148 T5367 T5368 poss its,regulation
R3149 T5368 T5366 pobj regulation,through
R3150 T5369 T5368 prep of,regulation
R3151 T5370 T5371 compound rhodopsin,levels
R3152 T5371 T5369 pobj levels,of
R3153 T5372 T5366 punct ", ",through
R3154 T5373 T5366 cc or,through
R3155 T5374 T5375 advmod perhaps,through
R3156 T5375 T5366 conj through,through
R3157 T5376 T5375 pobj control,through
R3158 T5377 T5376 prep of,control
R3159 T5378 T5379 det the,kinetics
R3160 T5379 T5377 pobj kinetics,of
R3161 T5380 T5379 prep of,kinetics
R3162 T5381 T5382 det the,regulation
R3163 T5382 T5380 pobj regulation,of
R3164 T5383 T5382 amod up,regulation
R3165 T5384 T5382 punct -,regulation
R3166 T5385 T5382 prep of,regulation
R3167 T5386 T5385 pobj rhodopsin,of
R3168 T5387 T5382 acl beginning,regulation
R3169 T5388 T5387 prep at,beginning
R3170 T5389 T5390 advmod about,P6
R3171 T5390 T5388 pobj P6,at
R3172 T5391 T5364 punct ", ",regulating
R3173 T5392 T5364 nsubj Crx,regulating
R3174 T5393 T5364 aux may,regulating
R3175 T5394 T5364 aux be,regulating
R3176 T5395 T5396 amod outer,segment
R3177 T5396 T5397 compound segment,morphogenesis
R3178 T5397 T5364 dobj morphogenesis,regulating
R3179 T5398 T5364 punct .,regulating
R3180 T5400 T5401 det The,similarty
R3181 T5401 T5402 nsubj similarty,extend
R3182 T5403 T5401 prep of,similarty
R3183 T5404 T5405 det the,cases
R3184 T5405 T5403 pobj cases,of
R3185 T5406 T5405 nummod two,cases
R3186 T5407 T5402 aux may,extend
R3187 T5408 T5402 advmod further,extend
R3188 T5409 T5402 punct .,extend
R3189 T5411 T5412 prep At,is
R3190 T5413 T5411 amod present,At
R3191 T5414 T5412 punct ", ",is
R3192 T5415 T5416 det the,Crx
R3193 T5416 T5412 nsubj Crx,is
R3194 T5417 T5416 amod closest,Crx
R3195 T5418 T5416 amod relative,Crx
R3196 T5419 T5416 prep in,Crx
R3197 T5420 T5419 pobj Drosophila,in
R3198 T5421 T5412 attr Otd,is
R3199 T5422 T5421 punct ", ",Otd
R3200 T5423 T5424 det the,member
R3201 T5424 T5421 appos member,Otd
R3202 T5425 T5424 amod founding,member
R3203 T5426 T5424 prep of,member
R3204 T5427 T5428 det the,class
R3205 T5428 T5426 pobj class,of
R3206 T5429 T5428 prep of,class
R3207 T5430 T5431 compound homeobox,genes
R3208 T5431 T5429 pobj genes,of
R3209 T5432 T5433 prep to,belongs
R3210 T5433 T5431 relcl belongs,genes
R3211 T5434 T5432 pobj which,to
R3212 T5435 T5433 nsubj Crx,belongs
R3213 T5436 T5412 punct .,is
R3214 T5438 T5439 advmod Interestingly,disrupted
R3215 T5440 T5439 punct ", ",disrupted
R3216 T5441 T5439 prep in,disrupted
R3217 T5442 T5443 nummod one,allele
R3218 T5443 T5441 pobj allele,in
R3219 T5444 T5443 amod hypomorphic,allele
R3220 T5445 T5443 prep of,allele
R3221 T5446 T5447 compound Drosophila,otd
R3222 T5447 T5445 pobj otd,of
R3223 T5448 T5443 punct ", ",allele
R3224 T5449 T5443 appos otduvi,allele
R3225 T5450 T5439 punct ", ",disrupted
R3226 T5451 T5452 compound photoreceptor,morphogenesis
R3227 T5452 T5439 nsubjpass morphogenesis,disrupted
R3228 T5453 T5439 auxpass is,disrupted
R3229 T5454 T5439 advmod also,disrupted
R3230 T5455 T5456 punct [,45
R3231 T5456 T5439 parataxis 45,disrupted
R3232 T5457 T5456 punct ],45
R3233 T5458 T5439 punct .,disrupted
R3234 T5460 T5461 nsubj We,found
R3235 T5462 T5463 mark that,are
R3236 T5463 T5461 ccomp are,found
R3237 T5464 T5463 expl there,are
R3238 T5465 T5466 amod many,genes
R3239 T5466 T5463 attr genes,are
R3240 T5467 T5466 amod other,genes
R3241 T5468 T5469 dep that,are
R3242 T5469 T5466 relcl are,genes
R3243 T5470 T5469 acomp dependent,are
R3244 T5471 T5470 prep upon,dependent
R3245 T5472 T5471 pobj Crx,upon
R3246 T5473 T5461 punct .,found
R3247 T5475 T5476 nsubj Those,comprise
R3248 T5477 T5478 dep that,expressed
R3249 T5478 T5475 relcl expressed,Those
R3250 T5479 T5478 auxpass are,expressed
R3251 T5480 T5478 prep at,expressed
R3252 T5481 T5482 det a,level
R3253 T5482 T5480 pobj level,at
R3254 T5483 T5482 amod lower,level
R3255 T5484 T5478 prep in,expressed
R3256 T5485 T5486 det the,retina
R3257 T5486 T5484 pobj retina,in
R3258 T5487 T5486 nmod Crx,retina
R3259 T5488 T5487 punct -,Crx
R3260 T5489 T5487 punct /,Crx
R3261 T5490 T5487 punct -,Crx
R3262 T5491 T5475 punct ", ",Those
R3263 T5492 T5493 amod such,as
R3264 T5493 T5475 prep as,Those
R3265 T5494 T5493 pobj rhodopsin,as
R3266 T5495 T5494 cc and,rhodopsin
R3267 T5496 T5494 conj peripherin,rhodopsin
R3268 T5497 T5476 punct ", ",comprise
R3269 T5498 T5476 dobj many,comprise
R3270 T5499 T5500 dep that,are
R3271 T5500 T5498 relcl are,many
R3272 T5501 T5502 advmod either,enriched
R3273 T5502 T5500 acomp enriched,are
R3274 T5503 T5502 cc or,enriched
R3275 T5504 T5502 conj specific,enriched
R3276 T5505 T5504 prep to,specific
R3277 T5506 T5505 pobj photoreceptors,to
R3278 T5507 T5500 prep in,are
R3279 T5508 T5509 poss their,expression
R3280 T5509 T5507 pobj expression,in
R3281 T5510 T5511 punct [,35
R3282 T5511 T5476 parataxis 35,comprise
R3283 T5512 T5511 punct ],35
R3284 T5513 T5476 punct .,comprise
R3285 T5515 T5516 nsubj They,include
R3286 T5517 T5516 dobj enzymes,include
R3287 T5518 T5519 dep that,are
R3288 T5519 T5517 relcl are,enzymes
R3289 T5520 T5519 acomp important,are
R3290 T5521 T5520 prep in,important
R3291 T5522 T5523 compound lipid,metabolism
R3292 T5523 T5521 pobj metabolism,in
R3293 T5524 T5523 punct ", ",metabolism
R3294 T5525 T5526 compound protein,folding
R3295 T5526 T5523 appos folding,metabolism
R3296 T5527 T5526 cc and,folding
R3297 T5528 T5526 conj transport,folding
R3298 T5529 T5521 punct ", ",in
R3299 T5530 T5531 advmod as,as
R3300 T5531 T5521 cc as,in
R3301 T5532 T5531 advmod well,as
R3302 T5533 T5521 conj in,in
R3303 T5534 T5535 amod other,processes
R3304 T5535 T5533 pobj processes,in
R3305 T5536 T5537 dep that,envision
R3306 T5537 T5535 relcl envision,processes
R3307 T5538 T5537 nsubj one,envision
R3308 T5539 T5537 aux might,envision
R3309 T5540 T5541 aux would,be
R3310 T5541 T5537 xcomp be,envision
R3311 T5542 T5541 acomp important,be
R3312 T5543 T5541 prep in,be
R3313 T5544 T5543 pcomp building,in
R3314 T5545 T5546 det a,structure
R3315 T5546 T5544 dobj structure,building
R3316 T5547 T5548 amod such,as
R3317 T5548 T5546 prep as,structure
R3318 T5549 T5550 det the,segment
R3319 T5550 T5548 pobj segment,as
R3320 T5551 T5550 amod outer,segment
R3321 T5552 T5516 punct .,include
R3322 T5554 T5555 advmod In,situ
R3323 T5555 T5556 amod situ,hybridization
R3324 T5556 T5557 nsubj hybridization,revealed
R3325 T5558 T5556 acl using,hybridization
R3326 T5559 T5558 dobj probes,using
R3327 T5560 T5559 prep from,probes
R3328 T5561 T5562 det this,collection
R3329 T5562 T5560 pobj collection,from
R3330 T5563 T5562 prep of,collection
R3331 T5564 T5563 pobj genes,of
R3332 T5565 T5557 aux has,revealed
R3333 T5566 T5567 mark that,have
R3334 T5567 T5557 ccomp have,revealed
R3335 T5568 T5567 nsubj some,have
R3336 T5569 T5568 prep of,some
R3337 T5570 T5569 pobj them,of
R3338 T5571 T5572 poss their,RNA
R3339 T5572 T5573 nsubj RNA,localized
R3340 T5573 T5567 ccomp localized,have
R3341 T5574 T5573 prep to,localized
R3342 T5575 T5576 det the,segment
R3343 T5576 T5574 pobj segment,to
R3344 T5577 T5576 amod inner,segment
R3345 T5578 T5557 punct ", ",revealed
R3346 T5579 T5580 det a,finding
R3347 T5580 T5557 npadvmod finding,revealed
R3348 T5581 T5580 amod typical,finding
R3349 T5582 T5581 prep for,typical
R3350 T5583 T5582 pobj proteins,for
R3351 T5584 T5583 acl targeted,proteins
R3352 T5585 T5584 prep to,targeted
R3353 T5586 T5587 det the,segment
R3354 T5587 T5585 pobj segment,to
R3355 T5588 T5587 amod outer,segment
R3356 T5589 T5557 punct .,revealed
R3357 T5591 T5592 amod Future,analyses
R3358 T5592 T5593 nsubj analyses,reveal
R3359 T5594 T5592 prep of,analyses
R3360 T5595 T5596 det the,function
R3361 T5596 T5594 pobj function,of
R3362 T5597 T5596 prep of,function
R3363 T5598 T5599 det these,genes
R3364 T5599 T5597 pobj genes,of
R3365 T5600 T5593 aux might,reveal
R3366 T5601 T5602 poss their,role
R3367 T5602 T5593 dobj role,reveal
R3368 T5603 T5602 prep in,role
R3369 T5604 T5605 amod outer,segment
R3370 T5605 T5606 compound segment,biogenesis
R3371 T5606 T5603 pobj biogenesis,in
R3372 T5607 T5593 punct .,reveal
R3373 T5609 T5610 advmod Finally,found
R3374 T5611 T5610 punct ", ",found
R3375 T5612 T5610 nsubjpass polarization,found
R3376 T5613 T5612 prep of,polarization
R3377 T5614 T5613 pobj photoreceptors,of
R3378 T5615 T5610 auxpass was,found
R3379 T5616 T5617 aux to,be
R3380 T5617 T5610 xcomp be,found
R3381 T5618 T5619 advmod largely,intact
R3382 T5619 T5617 acomp intact,be
R3383 T5620 T5617 punct ", ",be
R3384 T5621 T5622 mark as,was
R3385 T5622 T5617 advcl was,be
R3386 T5623 T5622 nsubj ciliogenesis,was
R3387 T5624 T5610 punct .,found
R3388 T5626 T5627 det Another,gene
R3389 T5627 T5629 nsubjpass gene,implicated
R3390 T5628 T5627 compound LCA,gene
R3391 T5630 T5627 punct ", ",gene
R3392 T5631 T5627 appos CRB1,gene
R3393 T5632 T5627 punct ", ",gene
R3394 T5633 T5627 cc and,gene
R3395 T5634 T5635 det a,gene
R3396 T5635 T5627 conj gene,gene
R3397 T5636 T5635 amod related,gene
R3398 T5637 T5635 appos CRB3,gene
R3399 T5638 T5629 punct ", ",implicated
R3400 T5639 T5629 aux have,implicated
R3401 T5640 T5629 auxpass been,implicated
R3402 T5641 T5629 prep in,implicated
R3403 T5642 T5641 pobj ciliogenesis,in
R3404 T5643 T5629 prep in,implicated
R3405 T5644 T5645 advmod in,vitro
R3406 T5645 T5646 amod vitro,models
R3407 T5646 T5643 pobj models,in
R3408 T5647 T5648 punct [,46
R3409 T5648 T5629 parataxis 46,implicated
R3410 T5649 T5648 punct ],46
R3411 T5650 T5629 punct .,implicated
R3412 T5652 T5653 det The,homologue
R3413 T5653 T5655 nsubjpass homologue,implicated
R3414 T5654 T5653 compound Drosophila,homologue
R3415 T5656 T5653 prep of,homologue
R3416 T5657 T5656 pobj CRB1,of
R3417 T5658 T5653 punct ", ",homologue
R3418 T5659 T5653 appos Crumbs,homologue
R3419 T5660 T5655 punct ", ",implicated
R3420 T5661 T5655 aux has,implicated
R3421 T5662 T5655 auxpass been,implicated
R3422 T5663 T5655 prep in,implicated
R3423 T5664 T5665 compound photoreceptor,morphogenesis
R3424 T5665 T5663 pobj morphogenesis,in
R3425 T5666 T5667 punct [,47
R3426 T5667 T5655 parataxis 47,implicated
R3427 T5668 T5667 punct ],47
R3428 T5669 T5655 punct .,implicated
R3429 T5671 T5672 advmod However,develops
R3430 T5673 T5672 punct ", ",develops
R3431 T5674 T5675 det the,mutant
R3432 T5675 T5672 nsubj mutant,develops
R3433 T5676 T5677 advmod spontaneously,occurring
R3434 T5677 T5675 amod occurring,mutant
R3435 T5678 T5675 compound mouse,mutant
R3436 T5679 T5675 prep in,mutant
R3437 T5680 T5679 pobj CRB1,in
R3438 T5681 T5675 punct ", ",mutant
R3439 T5682 T5683 det the,mouse
R3440 T5683 T5675 appos mouse,mutant
R3441 T5684 T5683 compound Rd8,mouse
R3442 T5685 T5672 punct ", ",develops
R3443 T5686 T5687 amod shortened,segments
R3444 T5687 T5672 dobj segments,develops
R3445 T5688 T5687 amod outer,segments
R3446 T5689 T5690 dep that,degenerate
R3447 T5690 T5687 relcl degenerate,segments
R3448 T5691 T5690 advmod subsequently,degenerate
R3449 T5692 T5693 punct [,48
R3450 T5693 T5672 parataxis 48,develops
R3451 T5694 T5693 punct ],48
R3452 T5695 T5672 punct ", ",develops
R3453 T5696 T5672 advcl suggesting,develops
R3454 T5697 T5698 mark that,are
R3455 T5698 T5696 ccomp are,suggesting
R3456 T5699 T5700 compound photoreceptor,polarization
R3457 T5700 T5698 nsubj polarization,are
R3458 T5701 T5700 cc and,polarization
R3459 T5702 T5700 conj synaptogenesis,polarization
R3460 T5703 T5698 acomp intact,are
R3461 T5704 T5698 prep in,are
R3462 T5705 T5706 det this,mutant
R3463 T5706 T5704 pobj mutant,in
R3464 T5707 T5672 punct .,develops
R3465 T5709 T5710 mark While,linked
R3466 T5710 T5717 advcl linked,is
R3467 T5711 T5710 nsubjpass CRB1,linked
R3468 T5712 T5711 cc and,CRB1
R3469 T5713 T5711 conj Crx,CRB1
R3470 T5714 T5710 aux have,linked
R3471 T5715 T5710 auxpass been,linked
R3472 T5716 T5710 advmod both,linked
R3473 T5718 T5710 prep to,linked
R3474 T5719 T5718 pobj LCA,to
R3475 T5720 T5717 punct ", ",is
R3476 T5721 T5722 amod further,work
R3477 T5722 T5717 nsubj work,is
R3478 T5723 T5717 acomp necessary,is
R3479 T5724 T5725 aux to,determine
R3480 T5725 T5723 xcomp determine,necessary
R3481 T5726 T5727 mark if,linked
R3482 T5727 T5725 ccomp linked,determine
R3483 T5728 T5729 poss their,function
R3484 T5729 T5727 nsubjpass function,linked
R3485 T5730 T5727 auxpass is,linked
R3486 T5731 T5727 prep in,linked
R3487 T5732 T5733 amod retinal,development
R3488 T5733 T5731 pobj development,in
R3489 T5734 T5717 punct .,is
R3492 T6165 T6166 nsubjpass Synaptogenesis,perturbed
R3493 T6167 T6166 auxpass is,perturbed
R3494 T6168 T6166 prep in,perturbed
R3495 T6169 T6170 nmod Crx,photoreceptors
R3496 T6170 T6168 pobj photoreceptors,in
R3497 T6171 T6169 punct -,Crx
R3498 T6172 T6169 punct /,Crx
R3499 T6173 T6169 punct -,Crx
R3500 T6175 T6176 det The,mouse
R3501 T6176 T6181 nsubj mouse,demonstrates
R3502 T6177 T6176 nmod Crx,mouse
R3503 T6178 T6177 punct -,Crx
R3504 T6179 T6177 punct /,Crx
R3505 T6180 T6177 punct -,Crx
R3506 T6182 T6183 det the,abnormality
R3507 T6183 T6181 dobj abnormality,demonstrates
R3508 T6184 T6185 advmod most,severe
R3509 T6185 T6183 amod severe,abnormality
R3510 T6186 T6183 prep of,abnormality
R3511 T6187 T6188 compound photoreceptor,synapses
R3512 T6188 T6186 pobj synapses,of
R3513 T6189 T6183 acl reported,abnormality
R3514 T6190 T6189 prep to,reported
R3515 T6191 T6190 pobj date,to
R3516 T6192 T6181 punct .,demonstrates
R3517 T6194 T6195 det The,mouse
R3518 T6195 T6200 nsubj mouse,develops
R3519 T6196 T6195 nmod peripherin,mouse
R3520 T6197 T6196 punct -,peripherin
R3521 T6198 T6196 punct /,peripherin
R3522 T6199 T6196 punct -,peripherin
R3523 T6201 T6202 det a,complement
R3524 T6202 T6200 dobj complement,develops
R3525 T6203 T6202 amod normal,complement
R3526 T6204 T6202 prep of,complement
R3527 T6205 T6206 compound photoreceptor,terminals
R3528 T6206 T6204 pobj terminals,of
R3529 T6207 T6208 dep which,degenerate
R3530 T6208 T6202 relcl degenerate,complement
R3531 T6209 T6208 advmod then,degenerate
R3532 T6210 T6211 mark as,lost
R3533 T6211 T6208 advcl lost,degenerate
R3534 T6212 T6213 det the,photoreceptors
R3535 T6213 T6211 nsubjpass photoreceptors,lost
R3536 T6214 T6211 auxpass are,lost
R3537 T6215 T6216 punct [,30
R3538 T6216 T6200 parataxis 30,develops
R3539 T6217 T6216 punct ],30
R3540 T6218 T6200 punct .,develops
R3541 T6220 T6221 advmod Also,reported
R3542 T6222 T6221 punct ", ",reported
R3543 T6223 T6221 advmod similarly,reported
R3544 T6224 T6221 prep in,reported
R3545 T6225 T6224 pobj rhodopsin,in
R3546 T6226 T6225 punct (,rhodopsin
R3547 T6227 T6225 appos Rho,rhodopsin
R3548 T6228 T6225 punct ),rhodopsin
R3549 T6229 T6225 cc and,rhodopsin
R3550 T6230 T6231 amod cyclic,channel
R3551 T6231 T6235 nmod channel,alpha
R3552 T6232 T6233 npadvmod nucleotide,gated
R3553 T6233 T6231 amod gated,channel
R3554 T6234 T6233 punct -,gated
R3555 T6235 T6237 nmod alpha,mice
R3556 T6236 T6235 punct ", ",alpha
R3557 T6237 T6225 conj mice,rhodopsin
R3558 T6238 T6235 punct -,alpha
R3559 T6239 T6235 nummod 3,alpha
R3560 T6240 T6235 punct (,alpha
R3561 T6241 T6235 appos CNGA3,alpha
R3562 T6242 T6237 punct ),mice
R3563 T6243 T6244 amod double,knockout
R3564 T6244 T6237 compound knockout,mice
R3565 T6245 T6237 punct (,mice
R3566 T6246 T6237 appos Rho,mice
R3567 T6247 T6246 punct -,Rho
R3568 T6248 T6246 punct /,Rho
R3569 T6249 T6246 punct -,Rho
R3570 T6250 T6246 punct ", ",Rho
R3571 T6251 T6246 appos CNGA3,Rho
R3572 T6252 T6251 punct -,CNGA3
R3573 T6253 T6251 punct /,CNGA3
R3574 T6254 T6251 punct -,CNGA3
R3575 T6255 T6221 punct ),reported
R3576 T6256 T6221 punct ", ",reported
R3577 T6257 T6221 nsubjpass synapses,reported
R3578 T6258 T6221 auxpass are,reported
R3579 T6259 T6260 aux to,form
R3580 T6260 T6221 xcomp form,reported
R3581 T6261 T6260 advmod normally,form
R3582 T6262 T6263 punct [,49
R3583 T6263 T6221 parataxis 49,reported
R3584 T6264 T6263 punct ],49
R3585 T6265 T6221 punct .,reported
R3586 T6267 T6268 det These,observations
R3587 T6268 T6269 nsubj observations,demonstrate
R3588 T6270 T6271 mark that,occur
R3589 T6271 T6269 ccomp occur,demonstrate
R3590 T6272 T6273 compound photoreceptor,synaptogenesis
R3591 T6273 T6271 nsubj synaptogenesis,occur
R3592 T6274 T6271 aux can,occur
R3593 T6275 T6271 prep in,occur
R3594 T6276 T6277 det the,absence
R3595 T6277 T6275 pobj absence,in
R3596 T6278 T6277 prep of,absence
R3597 T6279 T6280 amod outer,segment
R3598 T6280 T6281 compound segment,formation
R3599 T6281 T6278 pobj formation,of
R3600 T6282 T6269 punct .,demonstrate
R3601 T6284 T6285 prep In,is
R3602 T6286 T6284 pcomp keeping,In
R3603 T6287 T6286 prep with,keeping
R3604 T6288 T6289 det this,observation
R3605 T6289 T6287 pobj observation,with
R3606 T6290 T6291 det the,fact
R3607 T6291 T6285 nsubj fact,is
R3608 T6292 T6293 mark that,is
R3609 T6293 T6291 acl is,fact
R3610 T6294 T6295 det some,activity
R3611 T6295 T6293 nsubj activity,is
R3612 T6296 T6295 compound electroretinogram,activity
R3613 T6297 T6293 acomp present,is
R3614 T6298 T6293 prep in,is
R3615 T6299 T6300 nmod peripherin,mice
R3616 T6300 T6298 pobj mice,in
R3617 T6301 T6299 punct -,peripherin
R3618 T6302 T6299 punct /,peripherin
R3619 T6303 T6299 punct -,peripherin
R3620 T6304 T6293 punct ", ",is
R3621 T6305 T6293 advcl suggesting,is
R3622 T6306 T6307 mark that,is
R3623 T6307 T6305 ccomp is,suggesting
R3624 T6308 T6309 amod minimal,phototransduction
R3625 T6309 T6307 nsubj phototransduction,is
R3626 T6310 T6307 acomp present,is
R3627 T6311 T6307 prep in,is
R3628 T6312 T6313 det these,mice
R3629 T6313 T6311 pobj mice,in
R3630 T6314 T6307 punct ", ",is
R3631 T6315 T6307 advmod enough,is
R3632 T6316 T6317 aux to,drive
R3633 T6317 T6315 xcomp drive,enough
R3634 T6318 T6317 dobj activity,drive
R3635 T6319 T6317 prep at,drive
R3636 T6320 T6321 det the,synapse
R3637 T6321 T6319 pobj synapse,at
R3638 T6322 T6321 compound photoreceptor,synapse
R3639 T6323 T6285 punct .,is
R3640 T6325 T6326 advmod In,vitro
R3641 T6326 T6327 amod vitro,studies
R3642 T6327 T6328 nsubj studies,indicated
R3643 T6329 T6330 prep wherein,formed
R3644 T6330 T6327 relcl formed,studies
R3645 T6331 T6332 compound synapse,elements
R3646 T6332 T6330 nsubjpass elements,formed
R3647 T6333 T6330 auxpass are,formed
R3648 T6334 T6330 prep in,formed
R3649 T6335 T6336 det the,absence
R3650 T6336 T6334 pobj absence,in
R3651 T6337 T6336 prep of,absence
R3652 T6338 T6339 amod proper,development
R3653 T6339 T6337 pobj development,of
R3654 T6340 T6341 amod outer,segment
R3655 T6341 T6339 compound segment,development
R3656 T6342 T6336 cc and,absence
R3657 T6343 T6336 punct ", ",absence
R3658 T6344 T6345 advmod therefore,absence
R3659 T6345 T6336 conj absence,absence
R3660 T6346 T6345 punct ", ",absence
R3661 T6347 T6345 amod possible,absence
R3662 T6348 T6345 prep of,absence
R3663 T6349 T6350 npadvmod light,dependent
R3664 T6350 T6352 amod dependent,activity
R3665 T6351 T6350 punct -,dependent
R3666 T6352 T6348 pobj activity,of
R3667 T6353 T6352 compound photoreceptor,activity
R3668 T6354 T6328 punct ", ",indicated
R3669 T6355 T6328 aux have,indicated
R3670 T6356 T6357 det the,independence
R3671 T6357 T6328 dobj independence,indicated
R3672 T6358 T6357 prep of,independence
R3673 T6359 T6358 pobj phototransduction,of
R3674 T6360 T6359 cc and,phototransduction
R3675 T6361 T6362 compound synapse,formation
R3676 T6362 T6359 conj formation,phototransduction
R3677 T6363 T6328 punct ", ",indicated
R3678 T6364 T6365 advmod at,least
R3679 T6365 T6366 advmod least,for
R3680 T6366 T6328 prep for,indicated
R3681 T6367 T6368 det the,stages
R3682 T6368 T6366 pobj stages,for
R3683 T6369 T6368 amod initial,stages
R3684 T6370 T6371 punct [,51
R3685 T6371 T6328 parataxis 51,indicated
R3686 T6372 T6371 nummod 50,51
R3687 T6373 T6371 punct ",",51
R3688 T6374 T6371 punct ],51
R3689 T6375 T6328 punct .,indicated
R3690 T6377 T6378 det These,data
R3691 T6378 T6379 nsubj data,suggest
R3692 T6380 T6379 advmod then,suggest
R3693 T6381 T6382 mark that,is
R3694 T6382 T6379 ccomp is,suggest
R3695 T6383 T6384 det the,fact
R3696 T6384 T6382 nsubj fact,is
R3697 T6385 T6386 mark that,have
R3698 T6386 T6384 acl have,fact
R3699 T6387 T6388 det the,photoreceptors
R3700 T6388 T6386 nsubj photoreceptors,have
R3701 T6389 T6388 nmod Crx,photoreceptors
R3702 T6390 T6389 punct -,Crx
R3703 T6391 T6389 punct /,Crx
R3704 T6392 T6389 punct -,Crx
R3705 T6393 T6386 aux do,have
R3706 T6394 T6386 neg not,have
R3707 T6395 T6396 amod proper,endings
R3708 T6396 T6386 dobj endings,have
R3709 T6397 T6396 amod synaptic,endings
R3710 T6398 T6382 neg not,is
R3711 T6399 T6382 prep due,is
R3712 T6400 T6399 pcomp to,due
R3713 T6401 T6402 det a,lack
R3714 T6402 T6399 pobj lack,due
R3715 T6403 T6402 prep of,lack
R3716 T6404 T6405 amod outer,segment
R3717 T6405 T6406 compound segment,formation
R3718 T6406 T6403 pobj formation,of
R3719 T6407 T6379 punct .,suggest
R3720 T6409 T6410 det A,explanation
R3721 T6410 T6413 nsubj explanation,is
R3722 T6411 T6412 advmod more,likely
R3723 T6412 T6410 amod likely,explanation
R3724 T6414 T6415 mark that,plays
R3725 T6415 T6413 ccomp plays,is
R3726 T6416 T6415 nsubj Crx,plays
R3727 T6417 T6418 det a,role
R3728 T6418 T6415 dobj role,plays
R3729 T6419 T6415 prep in,plays
R3730 T6420 T6421 compound photoreceptor,synapse
R3731 T6421 T6422 compound synapse,formation
R3732 T6422 T6419 pobj formation,in
R3733 T6423 T6415 punct ", ",plays
R3734 T6424 T6425 advmod perhaps,by
R3735 T6425 T6415 prep by,plays
R3736 T6426 T6425 pcomp regulating,by
R3737 T6427 T6426 advmod directly,regulating
R3738 T6428 T6427 punct ", ",directly
R3739 T6429 T6427 cc or,directly
R3740 T6430 T6427 conj indirectly,directly
R3741 T6431 T6426 punct ", ",regulating
R3742 T6432 T6433 amod important,genes
R3743 T6433 T6426 dobj genes,regulating
R3744 T6434 T6433 prep in,genes
R3745 T6435 T6436 det this,process
R3746 T6436 T6434 pobj process,in
R3747 T6437 T6413 punct .,is
R3748 T6439 T6440 advcl Using,examined
R3749 T6441 T6439 dobj immunohistochemistry,Using
R3750 T6442 T6440 punct ", ",examined
R3751 T6443 T6440 nsubj we,examined
R3752 T6444 T6445 det the,expression
R3753 T6445 T6440 dobj expression,examined
R3754 T6446 T6440 prep of,examined
R3755 T6447 T6448 amod common,proteins
R3756 T6448 T6446 pobj proteins,of
R3757 T6449 T6448 amod pre-synaptic,proteins
R3758 T6450 T6448 amod terminal,proteins
R3759 T6451 T6448 punct ", ",proteins
R3760 T6452 T6448 prep including,proteins
R3761 T6453 T6452 pobj KIF3a,including
R3762 T6454 T6453 punct ", ",KIF3a
R3763 T6455 T6453 conj SV2,KIF3a
R3764 T6456 T6455 punct ", ",SV2
R3765 T6457 T6455 cc and,SV2
R3766 T6458 T6455 conj synaptophysin,SV2
R3767 T6459 T6440 punct ", ",examined
R3768 T6460 T6440 cc and,examined
R3769 T6461 T6440 conj were,examined
R3770 T6462 T6461 acomp unable,were
R3771 T6463 T6464 aux to,observe
R3772 T6464 T6462 xcomp observe,unable
R3773 T6465 T6466 amod qualitative,differences
R3774 T6466 T6464 dobj differences,observe
R3775 T6467 T6466 prep between,differences
R3776 T6468 T6469 nmod Crx,tissue
R3777 T6469 T6467 pobj tissue,between
R3778 T6470 T6468 punct -,Crx
R3779 T6471 T6468 punct /,Crx
R3780 T6472 T6468 punct -,Crx
R3781 T6473 T6468 cc and,Crx
R3782 T6474 T6468 conj control,Crx
R3783 T6475 T6464 prep at,observe
R3784 T6476 T6475 pobj P14,at
R3785 T6477 T6478 punct (,shown
R3786 T6478 T6464 parataxis shown,observe
R3787 T6479 T6478 nsubj data,shown
R3788 T6480 T6478 neg not,shown
R3789 T6481 T6478 punct ),shown
R3790 T6482 T6440 punct .,examined
R3791 T6484 T6485 nsubj Examination,showed
R3792 T6486 T6484 prep of,Examination
R3793 T6487 T6488 poss their,levels
R3794 T6488 T6486 pobj levels,of
R3795 T6489 T6488 compound RNA,levels
R3796 T6490 T6484 prep by,Examination
R3797 T6491 T6490 pobj SAGE,by
R3798 T6492 T6493 det no,difference
R3799 T6493 T6485 dobj difference,showed
R3800 T6494 T6493 amod significant,difference
R3801 T6495 T6485 prep for,showed
R3802 T6496 T6497 det all,genes
R3803 T6497 T6495 pobj genes,for
R3804 T6498 T6497 nummod 3,genes
R3805 T6499 T6485 punct ", ",showed
R3806 T6500 T6501 mark though,recovered
R3807 T6501 T6485 advcl recovered,showed
R3808 T6502 T6503 advmod very,few
R3809 T6503 T6504 amod few,tags
R3810 T6504 T6501 nsubjpass tags,recovered
R3811 T6505 T6501 auxpass were,recovered
R3812 T6506 T6501 prep from,recovered
R3813 T6507 T6508 det these,genes
R3814 T6508 T6506 pobj genes,from
R3815 T6509 T6501 cc and,recovered
R3816 T6510 T6511 advmod thus,be
R3817 T6511 T6501 conj be,recovered
R3818 T6512 T6513 det the,analysis
R3819 T6513 T6511 nsubj analysis,be
R3820 T6514 T6513 prep of,analysis
R3821 T6515 T6516 compound RNA,levels
R3822 T6516 T6514 pobj levels,of
R3823 T6517 T6511 aux may,be
R3824 T6518 T6511 neg not,be
R3825 T6519 T6511 acomp significant,be
R3826 T6520 T6521 punct [,35
R3827 T6521 T6511 parataxis 35,be
R3828 T6522 T6521 punct ],35
R3829 T6523 T6485 punct .,showed
R3830 T6525 T6526 advmod However,are
R3831 T6527 T6526 punct ", ",are
R3832 T6528 T6529 mark since,altered
R3833 T6529 T6526 advcl altered,are
R3834 T6530 T6531 amod other,genes
R3835 T6531 T6529 nsubjpass genes,altered
R3836 T6532 T6531 acl expressed,genes
R3837 T6533 T6532 prep in,expressed
R3838 T6534 T6533 pobj photoreceptors,in
R3839 T6535 T6529 auxpass were,altered
R3840 T6536 T6529 advmod significantly,altered
R3841 T6537 T6529 prep in,altered
R3842 T6538 T6539 poss their,level
R3843 T6539 T6537 pobj level,in
R3844 T6540 T6539 compound expression,level
R3845 T6541 T6529 prep in,altered
R3846 T6542 T6543 det the,mouse
R3847 T6543 T6541 pobj mouse,in
R3848 T6544 T6543 nmod Crx,mouse
R3849 T6545 T6544 punct -,Crx
R3850 T6546 T6544 punct /,Crx
R3851 T6547 T6544 punct -,Crx
R3852 T6548 T6526 punct ", ",are
R3853 T6549 T6526 expl there,are
R3854 T6550 T6551 amod many,candidates
R3855 T6551 T6526 attr candidates,are
R3856 T6552 T6553 dep that,be
R3857 T6553 T6551 relcl be,candidates
R3858 T6554 T6553 aux could,be
R3859 T6555 T6553 acomp important,be
R3860 T6556 T6555 prep for,important
R3861 T6557 T6558 compound photoreceptor,morphogenesis
R3862 T6558 T6556 pobj morphogenesis,for
R3863 T6559 T6526 punct .,are
R3864 T6561 T6562 nsubjpass Tags,found
R3865 T6563 T6561 prep from,Tags
R3866 T6564 T6565 nummod three,genes
R3867 T6565 T6563 pobj genes,from
R3868 T6566 T6565 prep from,genes
R3869 T6567 T6566 pobj proteins,from
R3870 T6568 T6567 acl expressed,proteins
R3871 T6569 T6568 prep in,expressed
R3872 T6570 T6571 compound photoreceptor,terminals
R3873 T6571 T6569 pobj terminals,in
R3874 T6572 T6562 auxpass were,found
R3875 T6573 T6574 aux to,decreased
R3876 T6574 T6562 xcomp decreased,found
R3877 T6575 T6574 auxpass be,decreased
R3878 T6576 T6574 prep in,decreased
R3879 T6577 T6578 det a,fashion
R3880 T6578 T6576 pobj fashion,in
R3881 T6579 T6580 advmod statistically,significant
R3882 T6580 T6578 amod significant,fashion
R3883 T6581 T6562 punct ", ",found
R3884 T6582 T6583 advmod namely,substrate
R3885 T6583 T6562 dobj substrate,found
R3886 T6584 T6583 det the,substrate
R3887 T6585 T6586 npadvmod HGF,regulated
R3888 T6586 T6583 amod regulated,substrate
R3889 T6587 T6586 punct -,regulated
R3890 T6588 T6589 compound tyrosine,kinase
R3891 T6589 T6583 compound kinase,substrate
R3892 T6590 T6583 punct ", ",substrate
R3893 T6591 T6592 det the,protein
R3894 T6592 T6583 conj protein,substrate
R3895 T6593 T6592 compound CRIPT,protein
R3896 T6594 T6592 punct ", ",protein
R3897 T6595 T6592 cc and,protein
R3898 T6596 T6592 conj synaptotagmin,protein
R3899 T6597 T6596 nummod 1,synaptotagmin
R3900 T6598 T6599 punct (,Blackshaw
R3901 T6599 T6562 meta Blackshaw,found
R3902 T6600 T6599 cc and,Blackshaw
R3903 T6601 T6599 conj Cepko,Blackshaw
R3904 T6602 T6601 punct ", ",Cepko
R3905 T6603 T6604 amod unpublished,data
R3906 T6604 T6601 conj data,Cepko
R3907 T6605 T6604 punct ),data
R3908 T6606 T6562 punct .,found
R3909 T6608 T6609 det An,example
R3910 T6609 T6610 nsubj example,is
R3911 T6611 T6609 prep of,example
R3912 T6612 T6613 det a,gene
R3913 T6613 T6611 pobj gene,of
R3914 T6614 T6615 dep that,increased
R3915 T6615 T6613 relcl increased,gene
R3916 T6616 T6615 auxpass was,increased
R3917 T6617 T6615 prep in,increased
R3918 T6618 T6619 det the,retina
R3919 T6619 T6617 pobj retina,in
R3920 T6620 T6619 nmod Crx,retina
R3921 T6621 T6620 punct -,Crx
R3922 T6622 T6620 punct /,Crx
R3923 T6623 T6620 punct -,Crx
R3924 T6624 T6610 attr HRG4,is
R3925 T6625 T6624 punct (,HRG4
R3926 T6626 T6627 det a,homologue
R3927 T6627 T6624 appos homologue,HRG4
R3928 T6628 T6627 prep of,homologue
R3929 T6629 T6630 det the,gene
R3930 T6630 T6628 pobj gene,of
R3931 T6631 T6632 compound C.,elegans
R3932 T6632 T6630 compound elegans,gene
R3933 T6633 T6630 compound Unc119,gene
R3934 T6634 T6624 punct ),HRG4
R3935 T6635 T6636 punct (,Blackshaw
R3936 T6636 T6624 meta Blackshaw,HRG4
R3937 T6637 T6636 cc and,Blackshaw
R3938 T6638 T6636 conj Cepko,Blackshaw
R3939 T6639 T6638 punct ", ",Cepko
R3940 T6640 T6641 amod unpublished,data
R3941 T6641 T6638 conj data,Cepko
R3942 T6642 T6641 punct ),data
R3943 T6643 T6644 dep which,encodes
R3944 T6644 T6624 relcl encodes,HRG4
R3945 T6645 T6646 det a,component
R3946 T6646 T6644 dobj component,encodes
R3947 T6647 T6646 prep of,component
R3948 T6648 T6649 det the,synapse
R3949 T6649 T6647 pobj synapse,of
R3950 T6650 T6649 compound ribbon,synapse
R3951 T6651 T6652 punct [,33
R3952 T6652 T6610 parataxis 33,is
R3953 T6653 T6652 punct ],33
R3954 T6654 T6610 punct .,is
R3955 T6656 T6657 det The,fact
R3956 T6657 T6658 nsubj fact,indicate
R3957 T6659 T6660 mark that,upregulated
R3958 T6660 T6657 acl upregulated,fact
R3959 T6661 T6660 nsubjpass it,upregulated
R3960 T6662 T6660 auxpass is,upregulated
R3961 T6663 T6658 aux might,indicate
R3962 T6664 T6665 det a,response
R3963 T6665 T6658 dobj response,indicate
R3964 T6666 T6665 prep to,response
R3965 T6667 T6668 det the,lack
R3966 T6668 T6666 pobj lack,to
R3967 T6669 T6668 prep of,lack
R3968 T6670 T6671 amod proper,structures
R3969 T6671 T6669 pobj structures,of
R3970 T6672 T6671 amod terminal,structures
R3971 T6673 T6658 punct .,indicate
R3972 T6675 T6676 amod Several,genes
R3973 T6676 T6678 nsubj genes,increased
R3974 T6677 T6676 amod other,genes
R3975 T6679 T6676 acl encoding,genes
R3976 T6680 T6681 amod putative,elements
R3977 T6681 T6679 dobj elements,encoding
R3978 T6682 T6681 amod cytoskeletal,elements
R3979 T6683 T6678 advmod also,increased
R3980 T6684 T6678 aux were,increased
R3981 T6685 T6686 punct (,protein
R3982 T6686 T6678 parataxis protein,increased
R3983 T6687 T6686 advmod e.g.,protein
R3984 T6688 T6689 npadvmod microtubule,associated
R3985 T6689 T6686 amod associated,protein
R3986 T6690 T6686 nummod 4,protein
R3987 T6691 T6686 punct ),protein
R3988 T6692 T6678 cc or,increased
R3989 T6693 T6678 conj decreased,increased
R3990 T6694 T6695 punct (,cofilin
R3991 T6695 T6693 parataxis cofilin,decreased
R3992 T6696 T6695 advmod e.g.,cofilin
R3993 T6697 T6695 nummod 1,cofilin
R3994 T6698 T6695 punct ),cofilin
R3995 T6699 T6678 prep in,increased
R3996 T6700 T6701 det the,retina
R3997 T6701 T6699 pobj retina,in
R3998 T6702 T6701 nmod Crx,retina
R3999 T6703 T6702 punct -,Crx
R4000 T6704 T6702 punct /,Crx
R4001 T6705 T6702 punct -,Crx
R4002 T6706 T6678 punct ", ",increased
R4003 T6707 T6678 prep with,increased
R4004 T6708 T6709 compound P,values
R4005 T6709 T6707 pobj values,with
R4006 T6710 T6709 prep of,values
R4007 T6711 T6712 punct <,.005
R4008 T6712 T6710 pobj .005,of
R4009 T6713 T6678 punct .,increased
R4010 T6715 T6716 nsubjpass It,known
R4011 T6717 T6716 auxpass is,known
R4012 T6718 T6716 neg not,known
R4013 T6719 T6720 mark whether,involved
R4014 T6720 T6716 ccomp involved,known
R4015 T6721 T6720 nsubjpass any,involved
R4016 T6722 T6721 prep of,any
R4017 T6723 T6724 det these,genes
R4018 T6724 T6722 pobj genes,of
R4019 T6725 T6720 auxpass are,involved
R4020 T6726 T6720 prep in,involved
R4021 T6727 T6726 pcomp building,in
R4022 T6728 T6727 cc or,building
R4023 T6729 T6727 conj regulating,building
R4024 T6730 T6731 amod synaptic,structures
R4025 T6731 T6729 dobj structures,regulating
R4026 T6732 T6716 punct ", ",known
R4027 T6733 T6716 cc but,known
R4028 T6734 T6735 nsubj they,are
R4029 T6735 T6716 conj are,known
R4030 T6736 T6735 advmod now,are
R4031 T6737 T6735 attr genes,are
R4032 T6738 T6739 dep that,lead
R4033 T6739 T6737 relcl lead,genes
R4034 T6740 T6739 aux might,lead
R4035 T6741 T6739 prep to,lead
R4036 T6742 T6743 det a,understanding
R4037 T6743 T6741 pobj understanding,to
R4038 T6744 T6743 amod better,understanding
R4039 T6745 T6743 prep of,understanding
R4040 T6746 T6747 det the,construction
R4041 T6747 T6745 pobj construction,of
R4042 T6748 T6747 cc and,construction
R4043 T6749 T6747 conj function,construction
R4044 T6750 T6747 prep of,construction
R4045 T6751 T6752 det the,structure
R4046 T6752 T6750 pobj structure,of
R4047 T6753 T6754 advmod relatively,unique
R4048 T6754 T6752 amod unique,structure
R4049 T6755 T6752 prep of,structure
R4050 T6756 T6757 det the,synapse
R4051 T6757 T6755 pobj synapse,of
R4052 T6758 T6757 compound ribbon,synapse
R4053 T6759 T6735 punct .,are
R4054 T6761 T6762 amod Abnormal,formation
R4055 T6762 T6765 nsubjpass formation,noted
R4056 T6763 T6764 compound photoreceptor,terminal
R4057 T6764 T6762 compound terminal,formation
R4058 T6766 T6765 auxpass was,noted
R4059 T6767 T6765 prep in,noted
R4060 T6768 T6769 det a,study
R4061 T6769 T6767 pobj study,in
R4062 T6770 T6771 dep that,examined
R4063 T6771 T6769 relcl examined,study
R4064 T6772 T6773 amod retinal,development
R4065 T6773 T6771 dobj development,examined
R4066 T6774 T6771 prep in,examined
R4067 T6775 T6776 det the,mouse
R4068 T6776 T6774 pobj mouse,in
R4069 T6777 T6778 compound laminin,chain
R4070 T6778 T6780 npadvmod chain,deficient
R4071 T6779 T6778 compound beta2,chain
R4072 T6780 T6776 amod deficient,mouse
R4073 T6781 T6780 punct -,deficient
R4074 T6782 T6783 punct [,52
R4075 T6783 T6765 parataxis 52,noted
R4076 T6784 T6783 punct ],52
R4077 T6785 T6765 punct .,noted
R4078 T6787 T6788 amod Several,pathologies
R4079 T6788 T6789 nsubjpass pathologies,noted
R4080 T6790 T6789 auxpass were,noted
R4081 T6791 T6789 prep in,noted
R4082 T6792 T6793 det these,mice
R4083 T6793 T6791 pobj mice,in
R4084 T6794 T6789 punct .,noted
R4085 T6796 T6797 advmod First,displayed
R4086 T6797 T6805 ccomp displayed,reduced
R4087 T6798 T6797 punct ", ",displayed
R4088 T6799 T6800 compound laminin,chain
R4089 T6800 T6802 npadvmod chain,deficient
R4090 T6801 T6800 compound beta2,chain
R4091 T6802 T6804 amod deficient,mice
R4092 T6803 T6802 punct -,deficient
R4093 T6804 T6797 nsubj mice,displayed
R4094 T6806 T6807 amod abnormal,elongation
R4095 T6807 T6797 dobj elongation,displayed
R4096 T6808 T6809 amod outer,segment
R4097 T6809 T6807 compound segment,elongation
R4098 T6810 T6807 punct ", ",elongation
R4099 T6811 T6807 cc but,elongation
R4100 T6812 T6813 det a,phenotype
R4101 T6813 T6807 conj phenotype,elongation
R4102 T6814 T6815 advmod more,mild
R4103 T6815 T6813 nmod mild,phenotype
R4104 T6816 T6813 prep than,phenotype
R4105 T6817 T6816 pobj that,than
R4106 T6818 T6817 prep of,that
R4107 T6819 T6820 det the,mice
R4108 T6820 T6818 pobj mice,of
R4109 T6821 T6820 nmod Crx,mice
R4110 T6822 T6821 punct -,Crx
R4111 T6823 T6821 punct /,Crx
R4112 T6824 T6821 punct -,Crx
R4113 T6825 T6805 punct ;,reduced
R4114 T6826 T6827 det the,segments
R4115 T6827 T6805 nsubjpass segments,reduced
R4116 T6828 T6827 amod outer,segments
R4117 T6829 T6805 auxpass were,reduced
R4118 T6830 T6805 prep by,reduced
R4119 T6831 T6832 nummod 50,%
R4120 T6832 T6830 pobj %,by
R4121 T6833 T6805 prep in,reduced
R4122 T6834 T6833 pobj length,in
R4123 T6835 T6805 punct .,reduced
R4124 T6837 T6838 advmod Also,perturbed
R4125 T6839 T6840 compound photoreceptor,terminals
R4126 T6840 T6838 nsubjpass terminals,perturbed
R4127 T6841 T6838 auxpass were,perturbed
R4128 T6842 T6838 prep in,perturbed
R4129 T6843 T6844 compound laminin,beta2
R4130 T6844 T6845 compound beta2,mutants
R4131 T6845 T6842 pobj mutants,in
R4132 T6846 T6838 punct ", ",perturbed
R4133 T6847 T6838 cc but,perturbed
R4134 T6848 T6849 advmod again,was
R4135 T6849 T6838 conj was,perturbed
R4136 T6850 T6851 det the,phenotype
R4137 T6851 T6849 nsubj phenotype,was
R4138 T6852 T6853 advmod more,subtle
R4139 T6853 T6849 acomp subtle,was
R4140 T6854 T6853 prep then,subtle
R4141 T6855 T6854 pobj that,then
R4142 T6856 T6855 prep of,that
R4143 T6857 T6858 nmod Crx,mice
R4144 T6858 T6856 pobj mice,of
R4145 T6859 T6857 punct -,Crx
R4146 T6860 T6857 punct /,Crx
R4147 T6861 T6857 punct -,Crx
R4148 T6862 T6849 punct .,was
R4149 T6864 T6865 det The,layer
R4150 T6865 T6868 nsubj layer,demonstrated
R4151 T6866 T6867 amod outer,plexiform
R4152 T6867 T6865 compound plexiform,layer
R4153 T6869 T6865 prep of,layer
R4154 T6870 T6871 det the,retinas
R4155 T6871 T6869 pobj retinas,of
R4156 T6872 T6873 npadvmod beta2,deficient
R4157 T6873 T6871 amod deficient,retinas
R4158 T6874 T6873 punct -,deficient
R4159 T6875 T6876 advmod only,7
R4160 T6876 T6877 nummod 7,%
R4161 T6877 T6878 nmod %,synapses
R4162 T6878 T6868 dobj synapses,demonstrated
R4163 T6879 T6878 amod normal,synapses
R4164 T6880 T6878 amod invaginating,synapses
R4165 T6881 T6868 punct ", ",demonstrated
R4166 T6882 T6883 mark while,had
R4167 T6883 T6868 advcl had,demonstrated
R4168 T6884 T6885 det the,remainder
R4169 T6885 T6883 nsubj remainder,had
R4170 T6886 T6887 amod various,pathologies
R4171 T6887 T6883 dobj pathologies,had
R4172 T6888 T6887 punct ", ",pathologies
R4173 T6889 T6887 prep including,pathologies
R4174 T6890 T6891 amod floating,ribbons
R4175 T6891 T6889 pobj ribbons,including
R4176 T6892 T6891 amod synaptic,ribbons
R4177 T6893 T6883 punct ", ",had
R4178 T6894 T6895 mark as,seen
R4179 T6895 T6883 advcl seen,had
R4180 T6896 T6895 advmod here,seen
R4181 T6897 T6868 punct .,demonstrated
R4182 T6899 T6900 det The,relationship
R4183 T6900 T6902 nsubj relationship,is
R4184 T6901 T6900 amod mechanistic,relationship
R4185 T6903 T6900 prep of,relationship
R4186 T6904 T6905 det these,molecules
R4187 T6905 T6903 pobj molecules,of
R4188 T6906 T6905 nummod two,molecules
R4189 T6907 T6908 punct ", ",any
R4190 T6908 T6900 parataxis any,relationship
R4191 T6909 T6908 mark if,any
R4192 T6910 T6908 punct ", ",any
R4193 T6911 T6900 prep in,relationship
R4194 T6912 T6913 compound photoreceptor,morphogenesis
R4195 T6913 T6911 pobj morphogenesis,in
R4196 T6914 T6902 acomp unknown,is
R4197 T6915 T6902 prep to,is
R4198 T6916 T6915 pobj date,to
R4199 T6917 T6902 punct .,is
R4200 T6919 T6920 det The,mRNA
R4201 T6920 T6921 nsubjpass mRNA,detected
R4202 T6922 T6920 prep for,mRNA
R4203 T6923 T6924 compound laminin,beta2
R4204 T6924 T6922 pobj beta2,for
R4205 T6925 T6921 auxpass was,detected
R4206 T6926 T6921 neg not,detected
R4207 T6927 T6921 prep in,detected
R4208 T6928 T6929 det the,study
R4209 T6929 T6927 pobj study,in
R4210 T6930 T6929 compound SAGE,study
R4211 T6931 T6929 prep of,study
R4212 T6932 T6933 det the,levels
R4213 T6933 T6931 pobj levels,of
R4214 T6934 T6933 amod relative,levels
R4215 T6935 T6933 compound RNA,levels
R4216 T6936 T6933 prep in,levels
R4217 T6937 T6936 pobj Crx,in
R4218 T6938 T6937 punct -,Crx
R4219 T6939 T6937 punct /,Crx
R4220 T6940 T6937 punct -,Crx
R4221 T6941 T6937 cc and,Crx
R4222 T6942 T6937 conj Crx,Crx
R4223 T6943 T6942 punct +,Crx
R4224 T6944 T6942 punct /,Crx
R4225 T6945 T6942 punct +,Crx
R4226 T6946 T6921 cc and,detected
R4227 T6947 T6948 advmod thus,comment
R4228 T6948 T6921 conj comment,detected
R4229 T6949 T6948 nsubj we,comment
R4230 T6950 T6948 aux can,comment
R4231 T6951 T6948 neg not,comment
R4232 T6952 T6948 prep on,comment
R4233 T6953 T6954 mark whether,altered
R4234 T6954 T6952 pcomp altered,on
R4235 T6955 T6956 det the,levels
R4236 T6956 T6954 nsubjpass levels,altered
R4237 T6957 T6956 prep of,levels
R4238 T6958 T6957 pobj RNA,of
R4239 T6959 T6956 prep for,levels
R4240 T6960 T6961 compound laminin,beta2
R4241 T6961 T6959 pobj beta2,for
R4242 T6962 T6954 auxpass were,altered
R4243 T6963 T6948 punct .,comment
R4246 T7157 T7158 nmod Crx,mice
R4247 T7158 T7162 nsubj mice,are
R4248 T7159 T7157 punct -,Crx
R4249 T7160 T7157 punct /,Crx
R4250 T7161 T7157 punct -,Crx
R4251 T7163 T7164 det a,model
R4252 T7164 T7162 attr model,are
R4253 T7165 T7164 prep for,model
R4254 T7166 T7165 pobj LCA,for
R4255 T7168 T7169 nsubjpass Crx,implicated
R4256 T7170 T7169 aux has,implicated
R4257 T7171 T7169 auxpass been,implicated
R4258 T7172 T7169 prep in,implicated
R4259 T7173 T7174 nummod three,diseases
R4260 T7174 T7172 pobj diseases,in
R4261 T7175 T7174 compound photoreceptor,diseases
R4262 T7176 T7177 dep that,result
R4263 T7177 T7174 relcl result,diseases
R4264 T7178 T7177 prep in,result
R4265 T7179 T7180 amod human,blindness
R4266 T7180 T7178 pobj blindness,in
R4267 T7181 T7180 punct ", ",blindness
R4268 T7182 T7183 compound cone,rod
R4269 T7183 T7185 compound rod,dystrophy2
R4270 T7184 T7183 punct -,rod
R4271 T7185 T7180 conj dystrophy2,blindness
R4272 T7186 T7185 punct ", ",dystrophy2
R4273 T7187 T7188 poss Leber,amaurosis
R4274 T7188 T7185 conj amaurosis,dystrophy2
R4275 T7189 T7187 case 's,Leber
R4276 T7190 T7188 amod congenital,amaurosis
R4277 T7191 T7188 punct ", ",amaurosis
R4278 T7192 T7188 cc and,amaurosis
R4279 T7193 T7194 compound retinitis,pigmentosa
R4280 T7194 T7188 conj pigmentosa,amaurosis
R4281 T7195 T7196 punct (,see
R4282 T7196 T7169 parataxis see,implicated
R4283 T7197 T7196 prep for,see
R4284 T7198 T7197 pobj review,for
R4285 T7199 T7196 punct ", ",see
R4286 T7200 T7196 punct [,see
R4287 T7201 T7196 dobj 53,see
R4288 T7202 T7196 punct ],see
R4289 T7203 T7196 punct ),see
R4290 T7204 T7169 punct .,implicated
R4291 T7206 T7207 det The,dystrophies
R4292 T7207 T7211 nsubjpass dystrophies,characterized
R4293 T7208 T7209 compound cone,rod
R4294 T7209 T7207 compound rod,dystrophies
R4295 T7210 T7209 punct -,rod
R4296 T7212 T7207 punct (,dystrophies
R4297 T7213 T7207 appos CRDs,dystrophies
R4298 T7214 T7207 punct ),dystrophies
R4299 T7215 T7211 auxpass are,characterized
R4300 T7216 T7211 agent by,characterized
R4301 T7217 T7216 pobj loss,by
R4302 T7218 T7217 prep of,loss
R4303 T7219 T7220 npadvmod cone,mediated
R4304 T7220 T7222 amod mediated,vision
R4305 T7221 T7220 punct -,mediated
R4306 T7222 T7218 pobj vision,of
R4307 T7223 T7211 prep in,characterized
R4308 T7224 T7225 det the,decade
R4309 T7225 T7223 pobj decade,in
R4310 T7226 T7225 amod first,decade
R4311 T7227 T7225 prep of,decade
R4312 T7228 T7227 pobj life,of
R4313 T7229 T7211 cc or,characterized
R4314 T7230 T7231 advmod later,with
R4315 T7231 T7211 conj with,characterized
R4316 T7232 T7231 punct ", ",with
R4317 T7233 T7234 amod concomitant,loss
R4318 T7234 T7231 pobj loss,with
R4319 T7235 T7233 cc or,concomitant
R4320 T7236 T7233 conj subsequent,concomitant
R4321 T7237 T7234 prep of,loss
R4322 T7238 T7239 npadvmod rod,mediated
R4323 T7239 T7241 amod mediated,vision
R4324 T7240 T7239 punct -,mediated
R4325 T7241 T7237 pobj vision,of
R4326 T7242 T7243 punct [,54
R4327 T7243 T7231 parataxis 54,with
R4328 T7244 T7243 punct ],54
R4329 T7245 T7211 punct .,characterized
R4330 T7247 T7248 advmod Conversely,is
R4331 T7249 T7248 punct ", ",is
R4332 T7250 T7248 nsubj RP,is
R4333 T7251 T7248 acomp notable,is
R4334 T7252 T7251 prep for,notable
R4335 T7253 T7254 amod initial,loss
R4336 T7254 T7252 pobj loss,for
R4337 T7255 T7254 prep of,loss
R4338 T7256 T7257 compound rod,function
R4339 T7257 T7255 pobj function,of
R4340 T7258 T7254 punct ", ",loss
R4341 T7259 T7254 acl followed,loss
R4342 T7260 T7259 agent by,followed
R4343 T7261 T7260 pobj loss,by
R4344 T7262 T7261 prep of,loss
R4345 T7263 T7264 npadvmod cone,mediated
R4346 T7264 T7266 amod mediated,vision
R4347 T7265 T7264 punct -,mediated
R4348 T7266 T7262 pobj vision,of
R4349 T7267 T7268 punct [,55
R4350 T7268 T7248 parataxis 55,is
R4351 T7269 T7268 punct ],55
R4352 T7270 T7248 punct .,is
R4353 T7272 T7273 det The,majority
R4354 T7273 T7274 nsubj majority,encode
R4355 T7275 T7273 prep of,majority
R4356 T7276 T7277 amod known,genes
R4357 T7277 T7275 pobj genes,of
R4358 T7278 T7277 amod responsible,genes
R4359 T7279 T7278 prep for,responsible
R4360 T7280 T7281 amod human,blindness
R4361 T7281 T7279 pobj blindness,for
R4362 T7282 T7281 amod genetic,blindness
R4363 T7283 T7274 punct ", ",encode
R4364 T7284 T7274 dobj proteins,encode
R4365 T7285 T7284 acl expressed,proteins
R4366 T7286 T7287 advmod almost,exclusively
R4367 T7287 T7288 advmod exclusively,in
R4368 T7288 T7285 prep in,expressed
R4369 T7289 T7287 punct ", ",exclusively
R4370 T7290 T7287 cc or,exclusively
R4371 T7291 T7287 conj exclusively,exclusively
R4372 T7292 T7288 punct ", ",in
R4373 T7293 T7288 pobj photoreceptors,in
R4374 T7294 T7293 punct ", ",photoreceptors
R4375 T7295 T7296 advmod particularly,in
R4376 T7296 T7293 prep in,photoreceptors
R4377 T7297 T7298 det the,segment
R4378 T7298 T7296 pobj segment,in
R4379 T7299 T7298 amod outer,segment
R4380 T7300 T7301 punct [,35
R4381 T7301 T7274 parataxis 35,encode
R4382 T7302 T7301 punct ],35
R4383 T7303 T7274 punct .,encode
R4384 T7305 T7306 nsubjpass Many,required
R4385 T7307 T7305 prep of,Many
R4386 T7308 T7309 det these,proteins
R4387 T7309 T7307 pobj proteins,of
R4388 T7310 T7306 auxpass are,required
R4389 T7311 T7306 prep for,required
R4390 T7312 T7311 pobj phototransduction,for
R4391 T7313 T7312 cc or,phototransduction
R4392 T7314 T7315 amod outer,segment
R4393 T7315 T7316 compound segment,structure
R4394 T7316 T7312 conj structure,phototransduction
R4395 T7317 T7306 punct .,required
R4396 T7319 T7320 det The,mechanisms
R4397 T7320 T7321 nsubj mechanisms,remain
R4398 T7322 T7323 advmod whereby,lead
R4399 T7323 T7320 relcl lead,mechanisms
R4400 T7324 T7323 nsubj mutations,lead
R4401 T7325 T7324 prep in,mutations
R4402 T7326 T7327 npadvmod rod,specific
R4403 T7327 T7329 amod specific,genes
R4404 T7328 T7327 punct -,specific
R4405 T7329 T7325 pobj genes,in
R4406 T7330 T7329 punct ", ",genes
R4407 T7331 T7332 amod such,as
R4408 T7332 T7329 prep as,genes
R4409 T7333 T7332 pobj rhodopsin,as
R4410 T7334 T7323 punct ", ",lead
R4411 T7335 T7323 advmod eventually,lead
R4412 T7336 T7323 prep to,lead
R4413 T7337 T7338 compound cone,degeneration
R4414 T7338 T7336 pobj degeneration,to
R4415 T7339 T7323 prep in,lead
R4416 T7340 T7339 pobj RP,in
R4417 T7341 T7321 acomp obscure,remain
R4418 T7342 T7321 punct .,remain
R4419 T7344 T7345 nsubj Mutations,were
R4420 T7346 T7344 prep in,Mutations
R4421 T7347 T7346 pobj Crx,in
R4422 T7348 T7349 det the,first
R4423 T7349 T7345 attr first,were
R4424 T7350 T7349 punct ", ",first
R4425 T7351 T7349 cc and,first
R4426 T7352 T7353 advmod still,one
R4427 T7353 T7354 nummod one,examples
R4428 T7354 T7349 conj examples,first
R4429 T7355 T7353 prep of,one
R4430 T7356 T7357 det a,few
R4431 T7357 T7355 pobj few,of
R4432 T7358 T7357 advmod very,few
R4433 T7359 T7349 prep of,first
R4434 T7360 T7361 det a,mutation
R4435 T7361 T7359 pobj mutation,of
R4436 T7362 T7363 compound transcription,factor
R4437 T7363 T7361 compound factor,mutation
R4438 T7364 T7361 acl leading,mutation
R4439 T7365 T7364 prep to,leading
R4440 T7366 T7367 compound photoreceptor,disease
R4441 T7367 T7365 pobj disease,to
R4442 T7368 T7345 punct .,were
R4443 T7370 T7371 nsubj LCA,is
R4444 T7372 T7373 det a,disease
R4445 T7373 T7371 attr disease,is
R4446 T7374 T7375 prep in,is
R4447 T7375 T7373 relcl is,disease
R4448 T7376 T7374 pobj which,in
R4449 T7377 T7375 expl there,is
R4450 T7378 T7379 amod little,function
R4451 T7379 T7375 attr function,is
R4452 T7380 T7378 cc or,little
R4453 T7381 T7378 conj no,little
R4454 T7382 T7379 compound photoreceptor,function
R4455 T7383 T7375 prep in,is
R4456 T7384 T7383 pobj infancy,in
R4457 T7385 T7373 punct ;,disease
R4458 T7386 T7387 advmod thereby,developmental
R4459 T7387 T7373 conj developmental,disease
R4460 T7388 T7387 punct ", ",developmental
R4461 T7389 T7387 advmod likely,developmental
R4462 T7390 T7387 prep in,developmental
R4463 T7391 T7390 pobj etiology,in
R4464 T7392 T7393 punct (,56
R4465 T7393 T7371 parataxis 56,is
R4466 T7394 T7393 punct [,56
R4467 T7395 T7393 nummod 17,56
R4468 T7396 T7393 punct ",",56
R4469 T7397 T7393 punct ],56
R4470 T7398 T7393 prep for,56
R4471 T7399 T7398 pobj review,for
R4472 T7400 T7393 punct ),56
R4473 T7401 T7371 punct .,is
R4474 T7403 T7404 det The,mouse
R4475 T7404 T7409 nsubj mouse,be
R4476 T7405 T7404 nmod Crx,mouse
R4477 T7406 T7405 punct -,Crx
R4478 T7407 T7405 punct /,Crx
R4479 T7408 T7405 punct -,Crx
R4480 T7410 T7409 aux may,be
R4481 T7411 T7412 det an,model
R4482 T7412 T7409 attr model,be
R4483 T7413 T7412 amod excellent,model
R4484 T7414 T7412 prep for,model
R4485 T7415 T7414 pcomp studying,for
R4486 T7416 T7417 det the,pathology
R4487 T7417 T7415 dobj pathology,studying
R4488 T7418 T7417 prep of,pathology
R4489 T7419 T7420 det this,disorder
R4490 T7420 T7418 pobj disorder,of
R4491 T7421 T7420 punct ", ",disorder
R4492 T7422 T7423 advmod particularly,subtype
R4493 T7423 T7420 appos subtype,disorder
R4494 T7424 T7423 det the,subtype
R4495 T7425 T7423 prep of,subtype
R4496 T7426 T7427 det the,disorder
R4497 T7427 T7425 pobj disorder,of
R4498 T7428 T7429 advmod where,involved
R4499 T7429 T7423 relcl involved,subtype
R4500 T7430 T7431 compound Crx,mutations
R4501 T7431 T7429 nsubjpass mutations,involved
R4502 T7432 T7429 auxpass are,involved
R4503 T7433 T7409 punct .,be
R4504 T7435 T7436 det The,majority
R4505 T7436 T7438 nsubjpass majority,derived
R4506 T7437 T7436 amod vast,majority
R4507 T7439 T7436 prep of,majority
R4508 T7440 T7441 amod histopathological,studies
R4509 T7441 T7439 pobj studies,of
R4510 T7442 T7441 prep of,studies
R4511 T7443 T7442 pobj LCA,of
R4512 T7444 T7441 prep in,studies
R4513 T7445 T7446 amod human,tissue
R4514 T7446 T7444 pobj tissue,in
R4515 T7447 T7438 aux have,derived
R4516 T7448 T7438 auxpass been,derived
R4517 T7449 T7438 prep from,derived
R4518 T7450 T7451 amod adult,patients
R4519 T7451 T7449 pobj patients,from
R4520 T7452 T7451 prep with,patients
R4521 T7453 T7452 pobj LCA,with
R4522 T7454 T7455 advmod where,are
R4523 T7455 T7451 relcl are,patients
R4524 T7456 T7457 amod secondary,changes
R4525 T7457 T7455 nsubj changes,are
R4526 T7458 T7455 acomp likely,are
R4527 T7459 T7460 aux to,be
R4528 T7460 T7458 xcomp be,likely
R4529 T7461 T7460 acomp present,be
R4530 T7462 T7438 punct .,derived
R4531 T7464 T7465 advmod Indeed,occur
R4532 T7466 T7465 prep in,occur
R4533 T7467 T7468 compound animal,models
R4534 T7468 T7466 pobj models,in
R4535 T7469 T7468 prep of,models
R4536 T7470 T7469 pobj LCA,of
R4537 T7471 T7465 punct ", ",occur
R4538 T7472 T7473 amod secondary,changes
R4539 T7473 T7465 nsubj changes,occur
R4540 T7474 T7473 amod reactive,changes
R4541 T7475 T7474 cc and,reactive
R4542 T7476 T7475 punct /,and
R4543 T7477 T7475 cc or,and
R4544 T7478 T7474 conj degenerative,reactive
R4545 T7479 T7480 advmod early,after
R4546 T7480 T7465 prep after,occur
R4547 T7481 T7482 det the,formation
R4548 T7482 T7480 pobj formation,after
R4549 T7483 T7482 amod abnormal,formation
R4550 T7484 T7482 prep of,formation
R4551 T7485 T7486 amod retinal,tissue
R4552 T7486 T7484 pobj tissue,of
R4553 T7487 T7488 punct [,57
R4554 T7488 T7465 parataxis 57,occur
R4555 T7489 T7488 punct ],57
R4556 T7490 T7465 punct .,occur
R4557 T7492 T7493 det The,study
R4558 T7493 T7495 nsubjpass study,reported
R4559 T7494 T7493 amod only,study
R4560 T7496 T7493 prep in,study
R4561 T7497 T7498 amod human,tissue
R4562 T7498 T7496 pobj tissue,in
R4563 T7499 T7498 acl derived,tissue
R4564 T7500 T7499 prep from,derived
R4565 T7501 T7502 det a,retina
R4566 T7502 T7500 pobj retina,from
R4567 T7503 T7502 amod human,retina
R4568 T7504 T7505 nummod 33,week
R4569 T7505 T7502 compound week,retina
R4570 T7506 T7505 punct -,week
R4571 T7507 T7502 prep with,retina
R4572 T7508 T7509 amod proposed,mutations
R4573 T7509 T7507 pobj mutations,with
R4574 T7510 T7509 compound RPE65,mutations
R4575 T7511 T7495 auxpass was,reported
R4576 T7512 T7513 aux to,have
R4577 T7513 T7495 xcomp have,reported
R4578 T7514 T7515 amod abnormal,retinae
R4579 T7515 T7513 dobj retinae,have
R4580 T7516 T7513 prep at,have
R4581 T7517 T7518 det this,stage
R4582 T7518 T7516 pobj stage,at
R4583 T7519 T7518 amod early,stage
R4584 T7520 T7521 punct [,24
R4585 T7521 T7495 parataxis 24,reported
R4586 T7522 T7521 punct ],24
R4587 T7523 T7495 punct .,reported
R4588 T7525 T7526 det These,authors
R4589 T7526 T7527 nsubj authors,report
R4590 T7528 T7529 compound cell,loss
R4591 T7529 T7527 dobj loss,report
R4592 T7530 T7529 punct ", ",loss
R4593 T7531 T7529 prep including,loss
R4594 T7532 T7531 pobj thinning,including
R4595 T7533 T7532 prep of,thinning
R4596 T7534 T7535 det the,layer
R4597 T7535 T7533 pobj layer,of
R4598 T7536 T7535 compound photoreceptor,layer
R4599 T7537 T7527 punct .,report
R4600 T7539 T7540 prep In,claim
R4601 T7541 T7539 pobj addition,In
R4602 T7542 T7540 punct ", ",claim
R4603 T7543 T7540 nsubj they,claim
R4604 T7544 T7540 prep in,claim
R4605 T7545 T7546 det the,text
R4606 T7546 T7544 pobj text,in
R4607 T7547 T7548 aux to,seen
R4608 T7548 T7540 xcomp seen,claim
R4609 T7549 T7548 aux have,seen
R4610 T7550 T7551 amod aberrant,organization
R4611 T7551 T7548 dobj organization,seen
R4612 T7552 T7551 amod synaptic,organization
R4613 T7553 T7552 cc and,synaptic
R4614 T7554 T7555 amod inner,retinal
R4615 T7555 T7552 conj retinal,synaptic
R4616 T7556 T7548 punct ", ",seen
R4617 T7557 T7558 mark although,presented
R4618 T7558 T7548 advcl presented,seen
R4619 T7559 T7560 poss their,examination
R4620 T7560 T7558 nsubjpass examination,presented
R4621 T7561 T7560 prep of,examination
R4622 T7562 T7563 compound photoreceptor,synapses
R4623 T7563 T7561 pobj synapses,of
R4624 T7564 T7558 advmod unfortunately,presented
R4625 T7565 T7558 auxpass are,presented
R4626 T7566 T7558 neg not,presented
R4627 T7567 T7558 prep in,presented
R4628 T7568 T7569 det the,section
R4629 T7569 T7567 pobj section,in
R4630 T7570 T7569 compound data,section
R4631 T7571 T7569 prep of,section
R4632 T7572 T7573 det the,paper
R4633 T7573 T7571 pobj paper,of
R4634 T7574 T7540 punct .,claim
R4635 T7576 T7577 prep Given,require
R4636 T7578 T7579 det the,scarcity
R4637 T7579 T7576 pobj scarcity,Given
R4638 T7580 T7579 prep of,scarcity
R4639 T7581 T7582 amod available,tissue
R4640 T7582 T7580 pobj tissue,of
R4641 T7583 T7582 amod human,tissue
R4642 T7584 T7577 punct ", ",require
R4643 T7585 T7586 det the,characterization
R4644 T7586 T7577 nsubj characterization,require
R4645 T7587 T7586 prep of,characterization
R4646 T7588 T7589 det the,pathology
R4647 T7589 T7587 pobj pathology,of
R4648 T7590 T7589 amod primary,pathology
R4649 T7591 T7589 prep of,pathology
R4650 T7592 T7591 pobj LCA,of
R4651 T7593 T7577 aux will,require
R4652 T7594 T7595 compound animal,models
R4653 T7595 T7577 dobj models,require
R4654 T7596 T7577 punct .,require
R4655 T7598 T7599 prep In,present
R4656 T7600 T7601 det the,study
R4657 T7601 T7598 pobj study,In
R4658 T7602 T7601 amod current,study
R4659 T7603 T7599 punct ", ",present
R4660 T7604 T7599 nsubj we,present
R4661 T7605 T7599 dobj data,present
R4662 T7606 T7607 dep that,argue
R4663 T7607 T7605 relcl argue,data
R4664 T7608 T7609 mark that,be
R4665 T7609 T7607 ccomp be,argue
R4666 T7610 T7609 punct ", ",be
R4667 T7611 T7609 prep in,be
R4668 T7612 T7611 pobj addition,in
R4669 T7613 T7612 prep to,addition
R4670 T7614 T7615 amod outer,segment
R4671 T7615 T7616 compound segment,morphogenesis
R4672 T7616 T7613 pobj morphogenesis,to
R4673 T7617 T7609 punct ", ",be
R4674 T7618 T7609 nsubj synaptogenesis,be
R4675 T7619 T7609 aux may,be
R4676 T7620 T7609 advmod also,be
R4677 T7621 T7622 advmod critically,impaired
R4678 T7622 T7609 acomp impaired,be
R4679 T7623 T7609 prep in,be
R4680 T7624 T7625 advmod at,a
R4681 T7625 T7627 nummod a,subset
R4682 T7626 T7625 advmod least,a
R4683 T7627 T7623 pobj subset,in
R4684 T7628 T7627 prep of,subset
R4685 T7629 T7628 pobj LCA,of
R4686 T7630 T7599 punct .,present
R4687 T7658 T7659 nmod Crx,mice
R4688 T7659 T7663 nsubjpass mice,generated
R4689 T7660 T7658 punct -,Crx
R4690 T7661 T7658 punct /,Crx
R4691 T7662 T7658 punct -,Crx
R4692 T7664 T7663 auxpass were,generated
R4693 T7665 T7666 mark as,reported
R4694 T7666 T7663 advcl reported,generated
R4695 T7667 T7666 advmod elsewhere,reported
R4696 T7668 T7669 punct [,34
R4697 T7669 T7663 parataxis 34,generated
R4698 T7670 T7669 punct ],34
R4699 T7671 T7663 punct .,generated
R4700 T7673 T7674 npadvmod Rhodosin,null
R4701 T7674 T7676 amod null,mice
R4702 T7675 T7674 punct -,null
R4703 T7676 T7677 nsubjpass mice,obtained
R4704 T7678 T7679 punct [,29
R4705 T7679 T7676 parataxis 29,mice
R4706 T7680 T7679 punct ],29
R4707 T7681 T7677 auxpass were,obtained
R4708 T7682 T7677 prep from,obtained
R4709 T7683 T7684 compound Paul,Sieving
R4710 T7684 T7682 pobj Sieving,from
R4711 T7685 T7686 punct (,University
R4712 T7686 T7677 parataxis University,obtained
R4713 T7687 T7686 prep of,University
R4714 T7688 T7687 pobj Michigan,of
R4715 T7689 T7686 punct ),University
R4716 T7690 T7677 punct .,obtained
R4717 T7692 T7693 compound Rds,mice
R4718 T7693 T7694 nsubjpass mice,acquired
R4719 T7695 T7694 auxpass were,acquired
R4720 T7696 T7694 prep from,acquired
R4721 T7697 T7698 compound Jackson,Laboratory
R4722 T7698 T7696 pobj Laboratory,from
R4723 T7699 T7694 punct .,acquired
R4724 T7779 T7780 compound Transmission,microscopy
R4725 T7781 T7780 compound electron,microscopy
R4726 T7783 T7784 nmod Littermate,pups
R4727 T7784 T7791 nsubjpass pups,perfused
R4728 T7785 T7784 nmod Crx,pups
R4729 T7786 T7785 punct -,Crx
R4730 T7787 T7785 punct /,Crx
R4731 T7788 T7785 punct -,Crx
R4732 T7789 T7785 cc and,Crx
R4733 T7790 T7785 conj wildtype,Crx
R4734 T7792 T7791 auxpass were,perfused
R4735 T7793 T7791 prep in,perfused
R4736 T7794 T7795 nummod 1,%
R4737 T7795 T7796 compound %,formaldehyde
R4738 T7796 T7793 pobj formaldehyde,in
R4739 T7797 T7796 cc and,formaldehyde
R4740 T7798 T7799 nummod 0.5,%
R4741 T7799 T7800 compound %,glutaraldehyde
R4742 T7800 T7796 conj glutaraldehyde,formaldehyde
R4743 T7801 T7791 prep at,perfused
R4744 T7802 T7803 amod various,stages
R4745 T7803 T7801 pobj stages,at
R4746 T7804 T7803 amod postnatal,stages
R4747 T7805 T7791 punct .,perfused
R4748 T7807 T7808 det The,eyes
R4749 T7808 T7809 nsubjpass eyes,enucleated
R4750 T7810 T7809 auxpass were,enucleated
R4751 T7811 T7809 advmod then,enucleated
R4752 T7812 T7809 punct ", ",enucleated
R4753 T7813 T7809 cc and,enucleated
R4754 T7814 T7815 det the,cornea
R4755 T7815 T7816 nsubjpass cornea,removed
R4756 T7816 T7809 conj removed,enucleated
R4757 T7817 T7815 cc and,cornea
R4758 T7818 T7815 conj lens,cornea
R4759 T7819 T7816 auxpass were,removed
R4760 T7820 T7816 punct .,removed
R4761 T7822 T7823 det The,cup
R4762 T7823 T7825 nsubjpass cup,immersed
R4763 T7824 T7823 compound eye,cup
R4764 T7826 T7825 auxpass was,immersed
R4765 T7827 T7825 prep in,immersed
R4766 T7828 T7827 pobj fixative,in
R4767 T7829 T7828 punct (,fixative
R4768 T7830 T7831 nummod 1,%
R4769 T7831 T7832 compound %,formaldehyde
R4770 T7832 T7828 appos formaldehyde,fixative
R4771 T7833 T7832 cc and,formaldehyde
R4772 T7834 T7835 nummod 2.5,%
R4773 T7835 T7836 compound %,glutaraldehyde
R4774 T7836 T7832 conj glutaraldehyde,formaldehyde
R4775 T7837 T7828 punct ),fixative
R4776 T7838 T7825 prep for,immersed
R4777 T7839 T7840 quantmod 3,4
R4778 T7840 T7842 nummod 4,hours
R4779 T7841 T7840 quantmod to,4
R4780 T7842 T7838 pobj hours,for
R4781 T7843 T7825 prep at,immersed
R4782 T7844 T7845 nummod 4,°C
R4783 T7845 T7843 pobj °C,at
R4784 T7846 T7825 punct .,immersed
R4785 T7848 T7849 det The,sclera
R4786 T7849 T7850 nsubjpass sclera,removed
R4787 T7851 T7850 auxpass was,removed
R4788 T7852 T7850 advmod then,removed
R4789 T7853 T7850 advmod partially,removed
R4790 T7854 T7850 cc and,removed
R4791 T7855 T7856 det the,retinas
R4792 T7856 T7857 nsubjpass retinas,sliced
R4793 T7857 T7850 conj sliced,removed
R4794 T7858 T7857 auxpass were,sliced
R4795 T7859 T7857 prep into,sliced
R4796 T7860 T7861 amod small,pieces
R4797 T7861 T7859 pobj pieces,into
R4798 T7862 T7857 cc and,sliced
R4799 T7863 T7857 conj fixed,sliced
R4800 T7864 T7865 punct (,paraformaldehyde
R4801 T7865 T7863 parataxis paraformaldehyde,fixed
R4802 T7866 T7867 nummod 1,%
R4803 T7867 T7865 compound %,paraformaldehyde
R4804 T7868 T7865 cc and,paraformaldehyde
R4805 T7869 T7870 nummod 2.5,%
R4806 T7870 T7871 compound %,glutaraldehyde
R4807 T7871 T7865 conj glutaraldehyde,paraformaldehyde
R4808 T7872 T7865 punct ),paraformaldehyde
R4809 T7873 T7863 advmod overnight,fixed
R4810 T7874 T7863 prep at,fixed
R4811 T7875 T7876 nummod 4,°C
R4812 T7876 T7874 pobj °C,at
R4813 T7877 T7857 punct .,sliced
R4814 T7879 T7880 det These,procedures
R4815 T7880 T7881 nsubjpass procedures,found
R4816 T7882 T7881 auxpass were,found
R4817 T7883 T7881 oprd optimal,found
R4818 T7884 T7883 prep for,optimal
R4819 T7885 T7884 pcomp maintaining,for
R4820 T7886 T7887 det the,integrity
R4821 T7887 T7885 dobj integrity,maintaining
R4822 T7888 T7887 amod structural,integrity
R4823 T7889 T7887 prep of,integrity
R4824 T7890 T7891 det the,segments
R4825 T7891 T7889 pobj segments,of
R4826 T7892 T7891 nmod photoreceptor,segments
R4827 T7893 T7891 amod outer,segments
R4828 T7894 T7881 punct .,found
R4829 T7896 T7897 prep After,washed
R4830 T7898 T7896 pobj fixing,After
R4831 T7899 T7897 punct ", ",washed
R4832 T7900 T7901 det the,tissue
R4833 T7901 T7897 nsubjpass tissue,washed
R4834 T7902 T7897 auxpass was,washed
R4835 T7903 T7897 npadvmod 2,washed
R4836 T7904 T7903 punct X,2
R4837 T7905 T7897 prep in,washed
R4838 T7906 T7905 pobj PBS,in
R4839 T7907 T7897 prep for,washed
R4840 T7908 T7909 nummod thirty,minutes
R4841 T7909 T7907 pobj minutes,for
R4842 T7910 T7909 prep per,minutes
R4843 T7911 T7910 pobj wash,per
R4844 T7912 T7897 punct .,washed
R4845 T7914 T7915 det The,tissue
R4846 T7915 T7916 nsubjpass tissue,postfixed
R4847 T7917 T7916 auxpass was,postfixed
R4848 T7918 T7916 advmod then,postfixed
R4849 T7919 T7916 prep in,postfixed
R4850 T7920 T7921 det a,mixture
R4851 T7921 T7919 pobj mixture,in
R4852 T7922 T7923 nummod 1,%
R4853 T7923 T7924 nmod %,tetroxide
R4854 T7924 T7921 nmod tetroxide,mixture
R4855 T7925 T7924 nmod osmium,tetroxide
R4856 T7926 T7924 punct /,tetroxide
R4857 T7927 T7928 nummod 1.5,%
R4858 T7928 T7929 compound %,ferrocyanide
R4859 T7929 T7924 appos ferrocyanide,tetroxide
R4860 T7930 T7929 compound potassium,ferrocyanide
R4861 T7931 T7916 prep for,postfixed
R4862 T7932 T7933 nummod 2,hours
R4863 T7933 T7931 pobj hours,for
R4864 T7934 T7916 prep at,postfixed
R4865 T7935 T7936 nummod 4,°C
R4866 T7936 T7934 pobj °C,at
R4867 T7937 T7916 punct .,postfixed
R4868 T7939 T7940 nsubjpass Staining,carried
R4869 T7941 T7940 auxpass was,carried
R4870 T7942 T7940 prt out,carried
R4871 T7943 T7940 prep for,carried
R4872 T7944 T7945 nummod 30,minutes
R4873 T7945 T7943 pobj minutes,for
R4874 T7946 T7940 prep in,carried
R4875 T7947 T7948 nummod 1,%
R4876 T7948 T7949 compound %,acetate
R4877 T7949 T7946 pobj acetate,in
R4878 T7950 T7949 compound uranyl,acetate
R4879 T7951 T7940 prep in,carried
R4880 T7952 T7953 compound maleate,buffer
R4881 T7953 T7951 pobj buffer,in
R4882 T7954 T7955 punct (,6.0
R4883 T7955 T7953 parataxis 6.0,buffer
R4884 T7956 T7955 nsubj pH,6.0
R4885 T7957 T7955 punct =,6.0
R4886 T7958 T7955 punct ),6.0
R4887 T7959 T7953 prep at,buffer
R4888 T7960 T7961 compound room,temperature
R4889 T7961 T7959 pobj temperature,at
R4890 T7962 T7953 acl followed,buffer
R4891 T7963 T7962 agent by,followed
R4892 T7964 T7965 nummod 1,%
R4893 T7965 T7966 nmod %,acid
R4894 T7966 T7963 pobj acid,by
R4895 T7967 T7966 amod tannic,acid
R4896 T7968 T7966 prep in,acid
R4897 T7969 T7970 nummod 0.1,M
R4898 T7970 T7971 compound M,buffer
R4899 T7971 T7968 pobj buffer,in
R4900 T7972 T7971 compound cacodylate,buffer
R4901 T7973 T7974 punct (,7.4
R4902 T7974 T7966 parataxis 7.4,acid
R4903 T7975 T7974 nsubj pH,7.4
R4904 T7976 T7974 punct =,7.4
R4905 T7977 T7974 punct ),7.4
R4906 T7978 T7966 prep for,acid
R4907 T7979 T7980 nummod thirty,minutes
R4908 T7980 T7978 pobj minutes,for
R4909 T7981 T7940 punct .,carried
R4910 T7983 T7984 det The,specimens
R4911 T7984 T7985 nsubjpass specimens,dehydrated
R4912 T7986 T7985 auxpass were,dehydrated
R4913 T7987 T7985 advmod then,dehydrated
R4914 T7988 T7985 cc and,dehydrated
R4915 T7989 T7985 conj embedded,dehydrated
R4916 T7990 T7989 prep in,embedded
R4917 T7991 T7992 compound Epon,Araldite
R4918 T7992 T7990 pobj Araldite,in
R4919 T7993 T7992 punct /,Araldite
R4920 T7994 T7985 punct .,dehydrated
R4921 T7996 T7997 amod Thin,sections
R4922 T7997 T7998 nsubjpass sections,stained
R4923 T7999 T7998 auxpass were,stained
R4924 T8000 T7998 prep with,stained
R4925 T8001 T8002 compound uranyl,acetate
R4926 T8002 T8000 pobj acetate,with
R4927 T8003 T8002 cc and,acetate
R4928 T8004 T8005 compound lead,citrate
R4929 T8005 T8002 conj citrate,acetate
R4930 T8006 T7998 punct ", ",stained
R4931 T8007 T7998 cc and,stained
R4932 T8008 T7998 conj examined,stained
R4933 T8009 T8008 prep in,examined
R4934 T8010 T8011 det a,microscope
R4935 T8011 T8009 pobj microscope,in
R4936 T8012 T8013 compound Jeol,1200EX
R4937 T8013 T8011 compound 1200EX,microscope
R4938 T8014 T8013 compound JEM,1200EX
R4939 T8015 T8013 punct -,1200EX
R4940 T8016 T8011 compound electron,microscope
R4941 T8017 T7998 punct .,stained
R4942 T8072 T8073 amod Scanning,microscopy
R4943 T8074 T8073 compound electron,microscopy
R4944 T8076 T8077 nsubj Specimens,required
R4945 T8078 T8076 acl used,Specimens
R4946 T8079 T8078 prep for,used
R4947 T8080 T8079 pobj SEM,for
R4948 T8081 T8077 dobj removal,required
R4949 T8082 T8081 prep of,removal
R4950 T8083 T8084 det the,epithelium
R4951 T8084 T8082 pobj epithelium,of
R4952 T8085 T8084 amod retinal,epithelium
R4953 T8086 T8084 compound pigment,epithelium
R4954 T8087 T8084 punct (,epithelium
R4955 T8088 T8084 appos PE,epithelium
R4956 T8089 T8077 punct ),required
R4957 T8090 T8077 punct ", ",required
R4958 T8091 T8077 advcl enabling,required
R4959 T8092 T8091 dobj visualization,enabling
R4960 T8093 T8092 prep of,visualization
R4961 T8094 T8095 det the,surface
R4962 T8095 T8093 pobj surface,of
R4963 T8096 T8095 amod outer,surface
R4964 T8097 T8095 prep of,surface
R4965 T8098 T8099 det the,retina
R4966 T8099 T8097 pobj retina,of
R4967 T8100 T8099 amod neural,retina
R4968 T8101 T8077 punct .,required
R4969 T8103 T8104 nsubjpass Retinae,dissected
R4970 T8105 T8103 prep from,Retinae
R4971 T8106 T8107 nmod Crx,eyes
R4972 T8107 T8105 pobj eyes,from
R4973 T8108 T8106 punct -,Crx
R4974 T8109 T8106 punct /,Crx
R4975 T8110 T8106 punct -,Crx
R4976 T8111 T8106 punct ", ",Crx
R4977 T8112 T8106 conj rhodopsin,Crx
R4978 T8113 T8112 punct -,rhodopsin
R4979 T8114 T8112 punct /,rhodopsin
R4980 T8115 T8112 punct -,rhodopsin
R4981 T8116 T8112 punct ", ",rhodopsin
R4982 T8117 T8112 conj RDS,rhodopsin
R4983 T8118 T8117 punct ", ",RDS
R4984 T8119 T8117 cc or,RDS
R4985 T8120 T8117 conj wildtype,RDS
R4986 T8121 T8104 auxpass were,dissected
R4987 T8122 T8104 oprd free,dissected
R4988 T8123 T8122 prep from,free
R4989 T8124 T8123 pobj PE,from
R4990 T8125 T8104 prep in,dissected
R4991 T8126 T8127 det a,solution
R4992 T8127 T8125 pobj solution,in
R4993 T8128 T8127 compound dispase,solution
R4994 T8129 T8104 cc and,dissected
R4995 T8130 T8104 conj fixed,dissected
R4996 T8131 T8130 prep in,fixed
R4997 T8132 T8133 nummod 1.25,%
R4998 T8133 T8134 compound %,glutaraldehyde
R4999 T8134 T8131 pobj glutaraldehyde,in
R5000 T8135 T8134 cc and,glutaraldehyde
R5001 T8136 T8137 nummod 1.0,%
R5002 T8137 T8138 compound %,formaldehyde
R5003 T8138 T8134 conj formaldehyde,glutaraldehyde
R5004 T8139 T8130 advmod overnight,fixed
R5005 T8140 T8130 prep at,fixed
R5006 T8141 T8142 nummod 4,°C
R5007 T8142 T8140 pobj °C,at
R5008 T8143 T8104 punct .,dissected
R5009 T8145 T8146 nsubjpass Tissue,washed
R5010 T8147 T8146 auxpass was,washed
R5011 T8148 T8146 advmod then,washed
R5012 T8149 T8146 npadvmod 5,washed
R5013 T8150 T8149 punct X,5
R5014 T8151 T8146 prep in,washed
R5015 T8152 T8153 compound cacodylate,buffer
R5016 T8153 T8151 pobj buffer,in
R5017 T8154 T8146 cc and,washed
R5018 T8155 T8146 conj dehydrated,washed
R5019 T8156 T8155 prep in,dehydrated
R5020 T8157 T8158 amod ascending,grades
R5021 T8158 T8156 pobj grades,in
R5022 T8159 T8158 prep of,grades
R5023 T8160 T8159 pobj ethanol,of
R5024 T8161 T8146 punct .,washed
R5025 T8163 T8164 nsubjpass Tissues,dried
R5026 T8165 T8164 auxpass were,dried
R5027 T8166 T8164 advmod subsequently,dried
R5028 T8167 T8168 amod critical,point
R5029 T8168 T8164 npadvmod point,dried
R5030 T8169 T8164 prep in,dried
R5031 T8170 T8171 compound carbon,dioxide
R5032 T8171 T8169 pobj dioxide,in
R5033 T8172 T8164 punct .,dried
R5034 T8174 T8175 det All,specimens
R5035 T8175 T8176 nsubjpass specimens,mounted
R5036 T8177 T8176 auxpass were,mounted
R5037 T8178 T8176 cc and,mounted
R5038 T8179 T8176 conj coated,mounted
R5039 T8180 T8179 prep with,coated
R5040 T8181 T8182 amod sublimated,palladium
R5041 T8182 T8180 pobj palladium,with
R5042 T8183 T8182 compound gold,palladium
R5043 T8184 T8182 punct -,palladium
R5044 T8185 T8179 prep by,coated
R5045 T8186 T8187 det the,technique
R5046 T8187 T8185 pobj technique,by
R5047 T8188 T8187 compound sputtering,technique
R5048 T8189 T8176 punct .,mounted
R5049 T8191 T8192 nsubjpass Micrographs,obtained
R5050 T8193 T8192 auxpass were,obtained
R5051 T8194 T8192 prep with,obtained
R5052 T8195 T8196 det a,microscope
R5053 T8196 T8194 pobj microscope,with
R5054 T8197 T8198 nmod Jeol,35CF
R5055 T8198 T8196 nmod 35CF,microscope
R5056 T8199 T8198 nmod JSM,35CF
R5057 T8200 T8198 punct -,35CF
R5058 T8201 T8196 amod scanning,microscope
R5059 T8202 T8196 compound electron,microscope
R5060 T8203 T8192 punct .,obtained
R5061 T8250 T8251 compound Transmission,microscopy
R5062 T8252 T8251 compound electron,microscopy
R5063 T8253 T8251 prep of,microscopy
R5064 T8254 T8255 det the,retina
R5065 T8255 T8253 pobj retina,of
R5066 T8256 T8255 amod outer,retina
R5067 T8257 T8251 prep at,microscopy
R5068 T8258 T8257 pobj P21,at
R5069 T8259 T8251 prep in,microscopy
R5070 T8260 T8261 punct (,A
R5071 T8261 T8262 meta A,Crx
R5072 T8262 T8264 nmod Crx,retinas
R5073 T8263 T8261 punct ),A
R5074 T8264 T8259 pobj retinas,in
R5075 T8265 T8262 punct +,Crx
R5076 T8266 T8262 punct /,Crx
R5077 T8267 T8262 punct +,Crx
R5078 T8268 T8262 cc and,Crx
R5079 T8269 T8270 punct (,B
R5080 T8270 T8271 meta B,Crx
R5081 T8271 T8262 conj Crx,Crx
R5082 T8272 T8270 punct ),B
R5083 T8273 T8271 punct -,Crx
R5084 T8274 T8271 punct /,Crx
R5085 T8275 T8271 punct -,Crx
R5086 T8276 T8251 punct .,microscopy
R5087 T8279 T8278 punct ", ",pe
R5088 T8280 T8281 amod pigmented,epithelium
R5089 T8281 T8278 appos epithelium,pe
R5090 T8282 T8278 punct .,pe
R5091 T8285 T8284 punct ", ",os
R5092 T8286 T8287 amod outer,segments
R5093 T8287 T8284 appos segments,os
R5094 T8288 T8284 punct .,os
R5095 T8291 T8290 punct ", ",is
R5096 T8292 T8293 amod inner,segments
R5097 T8293 T8290 appos segments,is
R5098 T8294 T8290 punct .,is
R5099 T8297 T8296 punct ", ",onl
R5100 T8298 T8299 amod outer,layer
R5101 T8299 T8296 appos layer,onl
R5102 T8300 T8299 amod nuclear,layer
R5103 T8301 T8299 prep with,layer
R5104 T8302 T8303 compound photoreceptor,nuclei
R5105 T8303 T8301 pobj nuclei,with
R5106 T8304 T8296 punct .,onl
R5107 T8306 T8307 compound Scale,bar
R5108 T8307 T8308 nsubj bar,μm
R5109 T8309 T8308 punct =,μm
R5110 T8310 T8308 nummod 5,μm
R5111 T8311 T8308 prep for,μm
R5112 T8312 T8311 pobj A,for
R5113 T8313 T8312 cc and,A
R5114 T8314 T8312 conj B,A
R5115 T8315 T8308 punct .,μm
R5118 T8372 T8373 compound Transmission,micrograph
R5119 T8374 T8373 compound electron,micrograph
R5120 T8375 T8373 prep of,micrograph
R5121 T8376 T8377 det the,layer
R5122 T8377 T8375 pobj layer,of
R5123 T8378 T8379 amod outer,segment
R5124 T8379 T8377 compound segment,layer
R5125 T8380 T8377 prep of,layer
R5126 T8381 T8382 nmod Crx,retina
R5127 T8382 T8380 pobj retina,of
R5128 T8383 T8381 punct -,Crx
R5129 T8384 T8381 punct /,Crx
R5130 T8385 T8381 punct -,Crx
R5131 T8386 T8373 prep at,micrograph
R5132 T8387 T8386 pobj P21,at
R5133 T8388 T8373 punct .,micrograph
R5134 T8390 T8391 amod Inner,segments
R5135 T8391 T8392 nsubj segments,exhibit
R5136 T8393 T8391 prep of,segments
R5137 T8394 T8395 nmod Crx,photoreceptors
R5138 T8395 T8393 pobj photoreceptors,of
R5139 T8396 T8394 punct -,Crx
R5140 T8397 T8394 punct /,Crx
R5141 T8398 T8394 punct -,Crx
R5142 T8399 T8400 amod numerous,mitochondria
R5143 T8400 T8392 dobj mitochondria,exhibit
R5144 T8401 T8402 punct (,indicated
R5145 T8402 T8400 parataxis indicated,mitochondria
R5146 T8403 T8402 nsubj m,indicated
R5147 T8404 T8402 agent by,indicated
R5148 T8405 T8404 pobj arrow,by
R5149 T8406 T8402 punct ),indicated
R5150 T8407 T8392 prep as,exhibit
R5151 T8408 T8407 prep in,as
R5152 T8409 T8408 pobj Crx,in
R5153 T8410 T8409 punct +,Crx
R5154 T8411 T8409 punct /,Crx
R5155 T8412 T8409 punct +,Crx
R5156 T8413 T8414 punct (,Figure
R5157 T8414 T8392 parataxis Figure,exhibit
R5158 T8415 T8414 nummod 1A,Figure
R5159 T8416 T8414 punct ),Figure
R5160 T8417 T8392 punct .,exhibit
R5161 T8420 T8419 punct ", ",pe
R5162 T8421 T8422 amod pigmented,epithelium
R5163 T8422 T8419 appos epithelium,pe
R5164 T8423 T8419 punct .,pe
R5165 T8426 T8425 punct ", ",is
R5166 T8427 T8428 amod inner,segments
R5167 T8428 T8425 appos segments,is
R5168 T8429 T8425 punct .,is
R5169 T8432 T8431 punct ", ",onl
R5170 T8433 T8434 amod outer,layer
R5171 T8434 T8431 appos layer,onl
R5172 T8435 T8434 amod nuclear,layer
R5173 T8436 T8431 punct .,onl
R5174 T8438 T8439 compound Scale,bar
R5175 T8439 T8440 nsubj bar,μm
R5176 T8441 T8440 punct =,μm
R5177 T8442 T8440 nummod 2,μm
R5178 T8443 T8440 punct .,μm
R5181 T8570 T8571 compound Transmission,micrograph
R5182 T8572 T8571 compound electron,micrograph
R5183 T8573 T8571 prep of,micrograph
R5184 T8574 T8575 nmod Crx,retina
R5185 T8575 T8573 pobj retina,of
R5186 T8576 T8574 punct -,Crx
R5187 T8577 T8574 punct /,Crx
R5188 T8578 T8574 punct -,Crx
R5189 T8579 T8575 prep at,retina
R5190 T8580 T8579 pobj P21,at
R5191 T8581 T8582 punct (,A
R5192 T8582 T8571 parataxis A,micrograph
R5193 T8583 T8582 cc and,A
R5194 T8584 T8582 conj B,A
R5195 T8585 T8582 punct ),A
R5196 T8586 T8571 punct ", ",micrograph
R5197 T8587 T8571 cc and,micrograph
R5198 T8588 T8589 amod scanning,micrograph
R5199 T8589 T8571 conj micrograph,micrograph
R5200 T8590 T8589 compound electron,micrograph
R5201 T8591 T8589 prep of,micrograph
R5202 T8592 T8591 pobj Crx,of
R5203 T8593 T8592 punct -,Crx
R5204 T8594 T8592 punct /,Crx
R5205 T8595 T8592 punct -,Crx
R5206 T8596 T8592 prep at,Crx
R5207 T8597 T8596 pobj P10,at
R5208 T8598 T8599 punct (,C
R5209 T8599 T8589 parataxis C,micrograph
R5210 T8600 T8599 punct ),C
R5211 T8601 T8571 prep of,micrograph
R5212 T8602 T8603 amod outer,segment
R5213 T8603 T8604 compound segment,layer
R5214 T8604 T8601 pobj layer,of
R5215 T8605 T8571 punct .,micrograph
R5216 T8607 T8608 punct (,A
R5217 T8608 T8609 meta A,Evidence
R5218 T8610 T8608 punct ),A
R5219 T8611 T8609 prep of,Evidence
R5220 T8612 T8611 pobj ciliogenesis,of
R5221 T8613 T8609 prep in,Evidence
R5222 T8614 T8615 det the,layer
R5223 T8615 T8613 pobj layer,in
R5224 T8616 T8615 compound photoreceptor,layer
R5225 T8617 T8615 prep of,layer
R5226 T8618 T8619 nmod Crx,retina
R5227 T8619 T8617 pobj retina,of
R5228 T8620 T8618 punct -,Crx
R5229 T8621 T8618 punct /,Crx
R5230 T8622 T8618 punct -,Crx
R5231 T8623 T8609 punct .,Evidence
R5232 T8625 T8626 amod Nonmotile,cilia
R5233 T8626 T8628 nsubjpass cilia,observed
R5234 T8627 T8626 amod connecting,cilia
R5235 T8629 T8628 auxpass were,observed
R5236 T8630 T8628 prep in,observed
R5237 T8631 T8632 compound cross,section
R5238 T8632 T8630 pobj section,in
R5239 T8633 T8634 punct (,1
R5240 T8634 T8628 parataxis 1,observed
R5241 T8635 T8634 nmod arrowheads,1
R5242 T8636 T8634 punct ",",1
R5243 T8637 T8634 conj 2,1
R5244 T8638 T8637 punct ", ",2
R5245 T8639 T8637 cc and,2
R5246 T8640 T8637 conj 3,2
R5247 T8641 T8634 punct ", ",1
R5248 T8642 T8634 prep for,1
R5249 T8643 T8642 pobj examples,for
R5250 T8644 T8634 punct ),1
R5251 T8645 T8628 punct .,observed
R5252 T8647 T8648 amod Connecting,cilium
R5253 T8648 T8649 nsubj cilium,demonstrated
R5254 T8650 T8648 nummod 1,cilium
R5255 T8651 T8652 punct (,arrowhead
R5256 T8652 T8648 parataxis arrowhead,cilium
R5257 T8653 T8652 nummod 1,arrowhead
R5258 T8654 T8652 punct ),arrowhead
R5259 T8655 T8656 nummod seven,doublets
R5260 T8656 T8649 dobj doublets,demonstrated
R5261 T8657 T8656 amod microtuble,doublets
R5262 T8658 T8649 punct ", ",demonstrated
R5263 T8659 T8660 mark while,exhibited
R5264 T8660 T8649 advcl exhibited,demonstrated
R5265 T8661 T8660 nsubj cilium,exhibited
R5266 T8662 T8661 nummod 2,cilium
R5267 T8663 T8661 cc and,cilium
R5268 T8664 T8661 conj cilium,cilium
R5269 T8665 T8664 nummod 3,cilium
R5270 T8666 T8660 dobj nine,exhibited
R5271 T8667 T8649 punct .,demonstrated
R5272 T8669 T8670 prep In,seen
R5273 T8671 T8669 pobj A,In
R5274 T8672 T8670 punct ", ",seen
R5275 T8673 T8674 det a,nucleus
R5276 T8674 T8670 nsubjpass nucleus,seen
R5277 T8675 T8674 amod displaced,nucleus
R5278 T8676 T8674 compound cell,nucleus
R5279 T8677 T8674 punct (,nucleus
R5280 T8678 T8674 appos n,nucleus
R5281 T8679 T8674 punct ),nucleus
R5282 T8680 T8674 acl appearing,nucleus
R5283 T8681 T8680 oprd pyknotic,appearing
R5284 T8682 T8674 cc and,nucleus
R5285 T8683 T8684 amod abnormal,deposition
R5286 T8684 T8674 conj deposition,nucleus
R5287 T8685 T8684 prep of,deposition
R5288 T8686 T8687 nmod matrix,material
R5289 T8687 T8685 pobj material,of
R5290 T8688 T8686 punct (,matrix
R5291 T8689 T8686 appos mx,matrix
R5292 T8690 T8687 punct ),material
R5293 T8691 T8687 prep of,material
R5294 T8692 T8693 amod unknown,identity
R5295 T8693 T8691 pobj identity,of
R5296 T8694 T8670 auxpass were,seen
R5297 T8695 T8670 punct ", ",seen
R5298 T8696 T8670 prep along,seen
R5299 T8697 T8696 prep with,along
R5300 T8698 T8699 amod large,amounts
R5301 T8699 T8697 pobj amounts,with
R5302 T8700 T8699 prep of,amounts
R5303 T8701 T8702 amod membranous,vesicles
R5304 T8702 T8700 pobj vesicles,of
R5305 T8703 T8704 punct (,arrow
R5306 T8704 T8702 parataxis arrow,vesicles
R5307 T8705 T8704 punct ),arrow
R5308 T8706 T8707 dep which,filled
R5309 T8707 T8699 relcl filled,amounts
R5310 T8708 T8709 det the,space
R5311 T8709 T8707 dobj space,filled
R5312 T8710 T8709 compound photoreceptor,space
R5313 T8711 T8707 cc and,filled
R5314 T8712 T8707 conj appeared,filled
R5315 T8713 T8714 aux to,released
R5316 T8714 T8712 xcomp released,appeared
R5317 T8715 T8714 auxpass be,released
R5318 T8716 T8714 prep from,released
R5319 T8717 T8718 amod inner,segments
R5320 T8718 T8716 pobj segments,from
R5321 T8719 T8670 punct .,seen
R5322 T8721 T8722 compound Scale,bar
R5323 T8722 T8723 nsubj bar,μm
R5324 T8724 T8723 punct =,μm
R5325 T8725 T8723 nummod 3.7,μm
R5326 T8726 T8723 punct .,μm
R5327 T8728 T8729 punct (,B
R5328 T8729 T8730 meta B,cilium
R5329 T8731 T8729 punct ),B
R5330 T8732 T8730 amod Nonmotile,cilium
R5331 T8733 T8730 amod connecting,cilium
R5332 T8734 T8730 prep in,cilium
R5333 T8735 T8736 compound cross,section
R5334 T8736 T8734 pobj section,in
R5335 T8737 T8730 punct ", ",cilium
R5336 T8738 T8730 prep from,cilium
R5337 T8739 T8740 det a,photoreceptor
R5338 T8740 T8738 pobj photoreceptor,from
R5339 T8741 T8740 nmod Crx,photoreceptor
R5340 T8742 T8741 punct -,Crx
R5341 T8743 T8741 punct /,Crx
R5342 T8744 T8741 punct -,Crx
R5343 T8745 T8730 punct ", ",cilium
R5344 T8746 T8730 acl demonstrating,cilium
R5345 T8747 T8748 amod characteristic,array
R5346 T8748 T8746 dobj array,demonstrating
R5347 T8749 T8750 nummod 9,0
R5348 T8750 T8748 nummod 0,array
R5349 T8751 T8750 punct +,0
R5350 T8752 T8748 amod radial,array
R5351 T8753 T8748 prep of,array
R5352 T8754 T8755 compound microtubule,doublets
R5353 T8755 T8753 pobj doublets,of
R5354 T8756 T8730 punct .,cilium
R5355 T8758 T8759 compound Scale,bar
R5356 T8759 T8760 nsubj bar,nm
R5357 T8761 T8760 punct =,nm
R5358 T8762 T8760 nummod 88,nm
R5359 T8763 T8760 punct .,nm
R5360 T8765 T8766 punct (,C
R5361 T8766 T8767 meta C,micrograph
R5362 T8768 T8766 punct ),C
R5363 T8769 T8767 amod Scanning,micrograph
R5364 T8770 T8767 compound electron,micrograph
R5365 T8771 T8772 punct (,SEM
R5366 T8772 T8767 appos SEM,micrograph
R5367 T8773 T8767 punct ),micrograph
R5368 T8774 T8767 prep of,micrograph
R5369 T8775 T8776 amod membranous,vesicles
R5370 T8776 T8774 pobj vesicles,of
R5371 T8777 T8778 punct (,shows
R5372 T8778 T8776 parataxis shows,vesicles
R5373 T8779 T8778 nsubj arrow,shows
R5374 T8780 T8781 nummod one,example
R5375 T8781 T8778 dobj example,shows
R5376 T8782 T8778 punct ),shows
R5377 T8783 T8776 acl shed,vesicles
R5378 T8784 T8783 prep from,shed
R5379 T8785 T8786 amod inner,segments
R5380 T8786 T8784 pobj segments,from
R5381 T8787 T8786 prep of,segments
R5382 T8788 T8789 nmod Crx,photoreceptors
R5383 T8789 T8787 pobj photoreceptors,of
R5384 T8790 T8788 punct -,Crx
R5385 T8791 T8788 punct /,Crx
R5386 T8792 T8788 punct -,Crx
R5387 T8793 T8783 prep at,shed
R5388 T8794 T8793 pobj P10,at
R5389 T8795 T8767 punct .,micrograph
R5390 T8797 T8798 nsubj Figure,shows
R5391 T8799 T8800 amod inner,segments
R5392 T8800 T8798 dobj segments,shows
R5393 T8801 T8800 acl viewed,segments
R5394 T8802 T8801 prep from,viewed
R5395 T8803 T8804 det the,side
R5396 T8804 T8802 pobj side,from
R5397 T8805 T8804 amod scleral,side
R5398 T8806 T8807 mark with,removed
R5399 T8807 T8798 advcl removed,shows
R5400 T8808 T8809 det the,epithelium
R5401 T8809 T8807 nsubj epithelium,removed
R5402 T8810 T8809 amod pigmented,epithelium
R5403 T8811 T8798 punct .,shows
R5404 T8813 T8814 compound Scale,bar
R5405 T8814 T8815 nsubj bar,μm
R5406 T8816 T8815 punct =,μm
R5407 T8817 T8815 nummod 1,μm
R5408 T8818 T8815 punct .,μm
R5409 T8923 T8924 compound Outer,segment
R5410 T8924 T8925 compound segment,morphogenesis
R5411 T8926 T8925 prep in,morphogenesis
R5412 T8927 T8928 nmod Crx,photoreceptors
R5413 T8928 T8926 pobj photoreceptors,in
R5414 T8929 T8927 punct -,Crx
R5415 T8930 T8927 punct /,Crx
R5416 T8931 T8927 punct -,Crx
R5417 T8932 T8925 punct .,morphogenesis
R5418 T8934 T8935 amod Scanning,microscopy
R5419 T8936 T8935 compound electron,microscopy
R5420 T8937 T8935 prep of,microscopy
R5421 T8938 T8939 amod developing,photoreceptors
R5422 T8939 T8937 pobj photoreceptors,of
R5423 T8940 T8939 acl viewed,photoreceptors
R5424 T8941 T8940 prep from,viewed
R5425 T8942 T8943 det the,side
R5426 T8943 T8941 pobj side,from
R5427 T8944 T8943 amod scleral,side
R5428 T8945 T8946 mark with,removed
R5429 T8946 T8940 advcl removed,viewed
R5430 T8947 T8948 det the,epithelium
R5431 T8948 T8946 nsubj epithelium,removed
R5432 T8949 T8948 amod pigmented,epithelium
R5433 T8950 T8946 prep at,removed
R5434 T8951 T8950 pobj P7,at
R5435 T8952 T8951 punct ", ",P7
R5436 T8953 T8951 conj P14,P7
R5437 T8954 T8953 punct ", ",P14
R5438 T8955 T8953 cc and,P14
R5439 T8956 T8953 conj P21,P14
R5440 T8957 T8946 prep for,removed
R5441 T8958 T8959 nmod Crx,littermates
R5442 T8959 T8957 pobj littermates,for
R5443 T8960 T8958 punct +,Crx
R5444 T8961 T8958 punct /,Crx
R5445 T8962 T8958 punct +,Crx
R5446 T8963 T8964 punct (,A
R5447 T8964 T8958 parataxis A,Crx
R5448 T8965 T8964 punct ", ",A
R5449 T8966 T8964 conj C,A
R5450 T8967 T8966 punct ", ",C
R5451 T8968 T8966 cc and,C
R5452 T8969 T8966 conj E,C
R5453 T8970 T8964 punct ),A
R5454 T8971 T8958 cc and,Crx
R5455 T8972 T8958 conj Crx,Crx
R5456 T8973 T8972 punct -,Crx
R5457 T8974 T8972 punct /,Crx
R5458 T8975 T8972 punct -,Crx
R5459 T8976 T8977 punct (,F
R5460 T8977 T8972 parataxis F,Crx
R5461 T8978 T8977 nmod B,F
R5462 T8979 T8977 punct ", ",F
R5463 T8980 T8977 nmod D,F
R5464 T8981 T8977 punct ", ",F
R5465 T8982 T8977 punct ),F
R5466 T8983 T8935 punct .,microscopy
R5467 T8985 T8986 prep In,were
R5468 T8987 T8988 nmod Crx,retina
R5469 T8988 T8985 pobj retina,In
R5470 T8989 T8987 punct +,Crx
R5471 T8990 T8987 punct /,Crx
R5472 T8991 T8987 punct +,Crx
R5473 T8992 T8986 punct ", ",were
R5474 T8993 T8994 amod numerous,cilia
R5475 T8994 T8986 nsubj cilia,were
R5476 T8995 T8994 amod connecting,cilia
R5477 T8996 T8997 punct (,cc
R5478 T8997 T8994 parataxis cc,cilia
R5479 T8998 T8997 dep A,cc
R5480 T8999 T8997 punct ", ",cc
R5481 T9000 T8997 punct ),cc
R5482 T9001 T8986 acomp evident,were
R5483 T9002 T8986 prep at,were
R5484 T9003 T9002 pobj P7,at
R5485 T9004 T8986 prep with,were
R5486 T9005 T9006 amod rudimentary,segments
R5487 T9006 T9004 pobj segments,with
R5488 T9007 T9006 amod outer,segments
R5489 T9008 T8986 punct .,were
R5490 T9010 T9011 prep After,occurs
R5491 T9012 T9010 pobj P7,After
R5492 T9013 T9011 punct ", ",occurs
R5493 T9014 T9011 prep in,occurs
R5494 T9015 T9014 pobj Crx,in
R5495 T9016 T9015 punct +,Crx
R5496 T9017 T9015 punct /,Crx
R5497 T9018 T9015 punct +,Crx
R5498 T9019 T9020 amod outer,segment
R5499 T9020 T9021 compound segment,elongation
R5500 T9021 T9011 nsubj elongation,occurs
R5501 T9022 T9011 punct .,occurs
R5502 T9024 T9025 advmod Initially,have
R5503 T9026 T9025 punct ", ",have
R5504 T9027 T9028 amod outer,segments
R5505 T9028 T9025 nsubj segments,have
R5506 T9029 T9030 det a,structure
R5507 T9030 T9025 dobj structure,have
R5508 T9031 T9032 npadvmod paddle,like
R5509 T9032 T9030 amod like,structure
R5510 T9033 T9032 punct -,like
R5511 T9034 T9035 punct (,os
R5512 T9035 T9030 parataxis os,structure
R5513 T9036 T9035 dep C,os
R5514 T9037 T9035 punct ", ",os
R5515 T9038 T9035 punct ),os
R5516 T9039 T9040 dep which,shed
R5517 T9040 T9030 relcl shed,structure
R5518 T9041 T9040 auxpass is,shed
R5519 T9042 T9040 advmod later,shed
R5520 T9043 T9044 punct (,os
R5521 T9044 T9040 parataxis os,shed
R5522 T9045 T9044 dep E,os
R5523 T9046 T9044 punct ", ",os
R5524 T9047 T9044 punct ),os
R5525 T9048 T9025 punct .,have
R5526 T9050 T9051 prep In,observed
R5527 T9052 T9053 nmod Crx,photoreceptors
R5528 T9053 T9050 pobj photoreceptors,In
R5529 T9054 T9052 punct -,Crx
R5530 T9055 T9052 punct /,Crx
R5531 T9056 T9052 punct -,Crx
R5532 T9057 T9051 punct ", ",observed
R5533 T9058 T9059 amod few,cilia
R5534 T9059 T9051 nsubjpass cilia,observed
R5535 T9060 T9059 amod connecting,cilia
R5536 T9061 T9051 auxpass were,observed
R5537 T9062 T9051 prep at,observed
R5538 T9063 T9062 pobj P7,at
R5539 T9064 T9065 punct (,cc
R5540 T9065 T9051 parataxis cc,observed
R5541 T9066 T9065 dep B,cc
R5542 T9067 T9065 punct ", ",cc
R5543 T9068 T9065 punct ),cc
R5544 T9069 T9051 punct .,observed
R5545 T9071 T9072 prep After,were
R5546 T9073 T9071 pobj P7,After
R5547 T9074 T9072 punct ", ",were
R5548 T9075 T9076 amod connecting,cilia
R5549 T9076 T9072 nsubj cilia,were
R5550 T9077 T9078 advmod more,numerous
R5551 T9078 T9072 acomp numerous,were
R5552 T9079 T9072 cc and,were
R5553 T9080 T9081 advmod occasionally,noted
R5554 T9081 T9072 conj noted,were
R5555 T9082 T9083 det a,segment
R5556 T9083 T9081 nsubjpass segment,noted
R5557 T9084 T9083 amod malformed,segment
R5558 T9085 T9083 amod outer,segment
R5559 T9086 T9081 auxpass was,noted
R5560 T9087 T9081 advcl extending,noted
R5561 T9088 T9087 prep from,extending
R5562 T9089 T9090 det a,cilium
R5563 T9090 T9088 pobj cilium,from
R5564 T9091 T9090 amod connecting,cilium
R5565 T9092 T9093 punct (,cc*
R5566 T9093 T9081 parataxis cc*,noted
R5567 T9094 T9093 dep D,cc*
R5568 T9095 T9094 cc and,D
R5569 T9096 T9094 conj F,D
R5570 T9097 T9093 punct ", ",cc*
R5571 T9098 T9093 punct ),cc*
R5572 T9099 T9081 punct .,noted
R5573 T9101 T9102 nsubjpass These,observed
R5574 T9103 T9102 auxpass were,observed
R5575 T9104 T9102 advmod rarely,observed
R5576 T9105 T9102 prep in,observed
R5577 T9106 T9105 pobj Crx,in
R5578 T9107 T9106 punct +,Crx
R5579 T9108 T9106 punct /,Crx
R5580 T9109 T9106 punct +,Crx
R5581 T9110 T9102 cc and,observed
R5582 T9111 T9112 advmod only,at
R5583 T9112 T9110 prep at,and
R5584 T9113 T9112 pobj P14,at
R5585 T9114 T9115 punct (,cc*
R5586 T9115 T9102 parataxis cc*,observed
R5587 T9116 T9115 dep C,cc*
R5588 T9117 T9115 punct ", ",cc*
R5589 T9118 T9115 punct ),cc*
R5590 T9119 T9102 punct .,observed
R5591 T9121 T9122 prep At,noted
R5592 T9123 T9121 pobj P21,At
R5593 T9124 T9122 punct ", ",noted
R5594 T9125 T9126 advmod abnormally,long
R5595 T9126 T9127 amod long,cilia
R5596 T9127 T9122 nsubjpass cilia,noted
R5597 T9128 T9127 amod connecting,cilia
R5598 T9129 T9122 auxpass are,noted
R5599 T9130 T9122 prep in,noted
R5600 T9131 T9130 pobj Crx,in
R5601 T9132 T9131 punct -,Crx
R5602 T9133 T9131 punct /,Crx
R5603 T9134 T9131 punct -,Crx
R5604 T9135 T9136 punct (,cc
R5605 T9136 T9122 parataxis cc,noted
R5606 T9137 T9136 dep F,cc
R5607 T9138 T9136 punct ", ",cc
R5608 T9139 T9136 punct ),cc
R5609 T9140 T9122 punct .,noted
R5610 T9142 T9143 compound Scale,bars
R5611 T9143 T9144 nsubj bars,μm
R5612 T9145 T9144 punct =,μm
R5613 T9146 T9144 nummod 10,μm
R5616 T9204 T9205 compound Transmission,micrographs
R5617 T9206 T9205 compound electron,micrographs
R5618 T9207 T9205 prep of,micrographs
R5619 T9208 T9209 nmod Crx,photoreceptors
R5620 T9209 T9207 pobj photoreceptors,of
R5621 T9210 T9208 punct -,Crx
R5622 T9211 T9208 punct /,Crx
R5623 T9212 T9208 punct -,Crx
R5624 T9213 T9205 prep in,micrographs
R5625 T9214 T9215 det the,layer
R5626 T9215 T9213 pobj layer,in
R5627 T9216 T9215 compound photoreceptor,layer
R5628 T9217 T9205 prep at,micrographs
R5629 T9218 T9217 pobj P7,at
R5630 T9219 T9205 punct .,micrographs
R5631 T9221 T9222 punct (,A
R5632 T9222 T9223 meta A,layer
R5633 T9224 T9222 punct ),A
R5634 T9225 T9223 compound Photoreceptor,layer
R5635 T9226 T9223 prep of,layer
R5636 T9227 T9228 nmod Crx,retina
R5637 T9228 T9226 pobj retina,of
R5638 T9229 T9227 punct +,Crx
R5639 T9230 T9227 punct /,Crx
R5640 T9231 T9227 punct +,Crx
R5641 T9232 T9223 acl demonstrating,layer
R5642 T9233 T9234 amod nascent,structures
R5643 T9234 T9237 nsubj structures,emerging
R5644 T9235 T9236 amod outer,segment
R5645 T9236 T9234 compound segment,structures
R5646 T9237 T9232 ccomp emerging,demonstrating
R5647 T9238 T9239 punct (,arrow
R5648 T9239 T9237 parataxis arrow,emerging
R5649 T9240 T9239 punct ),arrow
R5650 T9241 T9237 prep from,emerging
R5651 T9242 T9243 nmod photoreceptor,cilia
R5652 T9243 T9241 pobj cilia,from
R5653 T9244 T9243 amod connecting,cilia
R5654 T9245 T9243 punct (,cilia
R5655 T9246 T9243 appos cc,cilia
R5656 T9247 T9243 punct ),cilia
R5657 T9248 T9223 punct .,layer
R5658 T9250 T9251 punct (,B
R5659 T9251 T9252 meta B,observed
R5660 T9253 T9251 punct ),B
R5661 T9254 T9255 nmod Crx,photoreceptors
R5662 T9255 T9259 nsubj photoreceptors,exhibited
R5663 T9256 T9254 punct -,Crx
R5664 T9257 T9254 punct /,Crx
R5665 T9258 T9254 punct -,Crx
R5666 T9259 T9252 ccomp exhibited,observed
R5667 T9260 T9261 amod connecting,cilia
R5668 T9261 T9259 dobj cilia,exhibited
R5669 T9262 T9261 punct (,cilia
R5670 T9263 T9261 appos cc,cilia
R5671 T9264 T9259 punct ),exhibited
R5672 T9265 T9259 prep at,exhibited
R5673 T9266 T9267 det this,stage
R5674 T9267 T9265 pobj stage,at
R5675 T9268 T9267 amod early,stage
R5676 T9269 T9252 punct ", ",observed
R5677 T9270 T9252 advmod however,observed
R5678 T9271 T9252 punct ", ",observed
R5679 T9272 T9273 amod nascent,structures
R5680 T9273 T9252 nsubjpass structures,observed
R5681 T9274 T9275 amod outer,segment
R5682 T9275 T9273 compound segment,structures
R5683 T9276 T9252 auxpass were,observed
R5684 T9277 T9252 neg not,observed
R5685 T9278 T9252 punct .,observed
R5686 T9280 T9281 compound Scale,Bar
R5687 T9281 T9282 nsubj Bar,μm
R5688 T9283 T9282 punct =,μm
R5689 T9284 T9282 nummod 1,μm
R5690 T9285 T9282 punct .,μm
R5691 T9319 T9320 amod Scanning,microscopy
R5692 T9321 T9320 compound electron,microscopy
R5693 T9322 T9320 prep of,microscopy
R5694 T9323 T9324 nmod peripherin,photoreceptors
R5695 T9324 T9322 pobj photoreceptors,of
R5696 T9325 T9323 punct -,peripherin
R5697 T9326 T9323 punct /,peripherin
R5698 T9327 T9323 punct -,peripherin
R5699 T9328 T9329 punct (,A
R5700 T9329 T9323 parataxis A,peripherin
R5701 T9330 T9329 punct ),A
R5702 T9331 T9323 cc and,peripherin
R5703 T9332 T9323 conj rhodopsin,peripherin
R5704 T9333 T9332 punct -,rhodopsin
R5705 T9334 T9332 punct /,rhodopsin
R5706 T9335 T9332 punct -,rhodopsin
R5707 T9336 T9337 punct (,B
R5708 T9337 T9332 parataxis B,rhodopsin
R5709 T9338 T9337 punct ),B
R5710 T9339 T9320 prep at,microscopy
R5711 T9340 T9339 pobj P21,at
R5712 T9341 T9320 punct ", ",microscopy
R5713 T9342 T9320 acl viewed,microscopy
R5714 T9343 T9342 prep from,viewed
R5715 T9344 T9345 det the,side
R5716 T9345 T9343 pobj side,from
R5717 T9346 T9345 amod scleral,side
R5718 T9347 T9348 mark with,removed
R5719 T9348 T9342 advcl removed,viewed
R5720 T9349 T9350 det the,epithelium
R5721 T9350 T9348 nsubj epithelium,removed
R5722 T9351 T9350 amod pigmented,epithelium
R5723 T9352 T9320 punct .,microscopy
R5724 T9355 T9354 punct ", ",cc
R5725 T9356 T9357 amod connecting,cilium
R5726 T9357 T9354 appos cilium,cc
R5727 T9358 T9354 punct .,cc
R5728 T9361 T9360 punct ", ",is
R5729 T9362 T9363 amod inner,segment
R5730 T9363 T9360 appos segment,is
R5731 T9364 T9360 punct .,is
R5732 T9366 T9367 compound Scale,bar
R5733 T9367 T9368 nsubj bar,μm
R5734 T9369 T9368 punct =,μm
R5735 T9370 T9368 nummod 10,μm
R5736 T9371 T9368 punct .,μm
R5743 T9460 T9461 compound Transmission,micrographs
R5744 T9462 T9461 compound electron,micrographs
R5745 T9463 T9461 prep of,micrographs
R5746 T9464 T9465 det the,layer
R5747 T9465 T9463 pobj layer,of
R5748 T9466 T9467 amod outer,plexiform
R5749 T9467 T9465 compound plexiform,layer
R5750 T9468 T9461 prep in,micrographs
R5751 T9469 T9470 nmod Crx,retinas
R5752 T9470 T9468 pobj retinas,in
R5753 T9471 T9469 punct -,Crx
R5754 T9472 T9469 punct /,Crx
R5755 T9473 T9469 punct -,Crx
R5756 T9474 T9461 punct .,micrographs
R5757 T9476 T9477 punct (,A
R5758 T9477 T9478 meta A,were
R5759 T9479 T9477 punct ),A
R5760 T9480 T9478 prep In,were
R5761 T9481 T9482 nmod Crx,retina
R5762 T9482 T9480 pobj retina,In
R5763 T9483 T9481 punct +,Crx
R5764 T9484 T9481 punct /,Crx
R5765 T9485 T9481 punct +,Crx
R5766 T9486 T9478 prep at,were
R5767 T9487 T9486 pobj P21,at
R5768 T9488 T9478 punct ", ",were
R5769 T9489 T9490 advmod newly,formed
R5770 T9490 T9491 amod formed,spherules
R5771 T9491 T9478 nsubj spherules,were
R5772 T9492 T9491 compound rod,spherules
R5773 T9493 T9478 acomp abundant,were
R5774 T9494 T9495 punct (,demonstrates
R5775 T9495 T9478 parataxis demonstrates,were
R5776 T9496 T9495 nsubj arrow,demonstrates
R5777 T9497 T9498 nummod one,example
R5778 T9498 T9495 dobj example,demonstrates
R5779 T9499 T9495 punct ),demonstrates
R5780 T9500 T9478 punct .,were
R5781 T9502 T9503 det The,spherules
R5782 T9503 T9504 nsubj spherules,were
R5783 T9505 T9506 npadvmod club,shaped
R5784 T9506 T9504 acomp shaped,were
R5785 T9507 T9506 punct -,shaped
R5786 T9508 T9504 cc and,were
R5787 T9509 T9504 conj contained,were
R5788 T9510 T9511 det a,synapse
R5789 T9511 T9509 dobj synapse,contained
R5790 T9512 T9511 amod single,synapse
R5791 T9513 T9511 amod invaginating,synapse
R5792 T9514 T9511 prep with,synapse
R5793 T9515 T9516 nummod one,complex
R5794 T9516 T9514 pobj complex,with
R5795 T9517 T9516 compound ribbon,complex
R5796 T9518 T9504 punct .,were
R5797 T9520 T9521 compound Cone,terminals
R5798 T9521 T9522 nsubj terminals,form
R5799 T9523 T9524 amod large,pedicles
R5800 T9524 T9522 dobj pedicles,form
R5801 T9525 T9524 punct ", ",pedicles
R5802 T9526 T9524 amod flat,pedicles
R5803 T9527 T9528 dep that,contain
R5804 T9528 T9524 relcl contain,pedicles
R5805 T9529 T9530 amod many,synapses
R5806 T9530 T9528 dobj synapses,contain
R5807 T9531 T9530 amod invaginating,synapses
R5808 T9532 T9530 prep with,synapses
R5809 T9533 T9534 amod separate,structures
R5810 T9534 T9532 pobj structures,with
R5811 T9535 T9534 compound ribbon,structures
R5812 T9536 T9522 punct .,form
R5813 T9538 T9539 det These,terminals
R5814 T9539 T9540 nsubj terminals,were
R5815 T9541 T9542 advmod more,scarce
R5816 T9542 T9540 acomp scarce,were
R5817 T9543 T9542 punct ", ",scarce
R5818 T9544 T9542 cc but,scarce
R5819 T9545 T9542 conj apparent,scarce
R5820 T9546 T9540 prep in,were
R5821 T9547 T9548 nmod Crx,retinas
R5822 T9548 T9546 pobj retinas,in
R5823 T9549 T9547 punct +,Crx
R5824 T9550 T9547 punct /,Crx
R5825 T9551 T9547 punct +,Crx
R5826 T9552 T9540 prep at,were
R5827 T9553 T9552 pobj P21,at
R5828 T9554 T9555 punct (,example
R5829 T9555 T9553 parataxis example,P21
R5830 T9556 T9555 nummod one,example
R5831 T9557 T9555 prep in,example
R5832 T9558 T9557 pobj box,in
R5833 T9559 T9555 punct ),example
R5834 T9560 T9540 punct .,were
R5835 T9562 T9563 punct (,B
R5836 T9563 T9564 meta B,appeared
R5837 T9565 T9563 punct ),B
R5838 T9566 T9564 prep In,appeared
R5839 T9567 T9568 det the,layer
R5840 T9568 T9566 pobj layer,In
R5841 T9569 T9568 amod outer,layer
R5842 T9570 T9568 compound plexiform,layer
R5843 T9571 T9568 punct (,layer
R5844 T9572 T9568 appos OPL,layer
R5845 T9573 T9568 punct ),layer
R5846 T9574 T9568 prep of,layer
R5847 T9575 T9576 nmod Crx,retinas
R5848 T9576 T9574 pobj retinas,of
R5849 T9577 T9575 punct -,Crx
R5850 T9578 T9575 punct /,Crx
R5851 T9579 T9575 punct -,Crx
R5852 T9580 T9564 punct ", ",appeared
R5853 T9581 T9582 compound photoreceptor,terminals
R5854 T9582 T9564 nsubj terminals,appeared
R5855 T9583 T9584 advmod highly,disorganized
R5856 T9584 T9564 oprd disorganized,appeared
R5857 T9585 T9564 prep at,appeared
R5858 T9586 T9585 pobj P21,at
R5859 T9587 T9588 punct (,arrows
R5860 T9588 T9564 parataxis arrows,appeared
R5861 T9589 T9588 punct ),arrows
R5862 T9590 T9564 punct .,appeared
R5863 T9592 T9593 advmod Well,formed
R5864 T9593 T9595 amod formed,pedicles
R5865 T9594 T9593 punct -,formed
R5866 T9595 T9596 nsubj pedicles,were
R5867 T9597 T9595 cc and,pedicles
R5868 T9598 T9595 conj spherules,pedicles
R5869 T9599 T9596 neg not,were
R5870 T9600 T9596 acomp evident,were
R5871 T9601 T9596 punct .,were
R5872 T9603 T9604 amod Putative,terminals
R5873 T9604 T9605 nsubj terminals,were
R5874 T9606 T9604 acl containing,terminals
R5875 T9607 T9608 npadvmod ribbon,like
R5876 T9608 T9610 amod like,structures
R5877 T9609 T9608 punct -,like
R5878 T9610 T9606 dobj structures,containing
R5879 T9611 T9605 acomp apparent,were
R5880 T9612 T9605 punct ", ",were
R5881 T9613 T9605 advcl suggesting,were
R5882 T9614 T9615 advmod at,least
R5883 T9615 T9616 advmod least,limited
R5884 T9616 T9617 amod limited,generation
R5885 T9617 T9613 dobj generation,suggesting
R5886 T9618 T9617 prep of,generation
R5887 T9619 T9620 compound synapse,components
R5888 T9620 T9618 pobj components,of
R5889 T9621 T9605 punct .,were
R5890 T9623 T9624 amod Many,terminals
R5891 T9624 T9625 nsubj terminals,appeared
R5892 T9626 T9627 aux to,contain
R5893 T9627 T9625 xcomp contain,appeared
R5894 T9628 T9629 amod multiple,structures
R5895 T9629 T9627 dobj structures,contain
R5896 T9630 T9631 npadvmod ribbon,like
R5897 T9631 T9629 amod like,structures
R5898 T9632 T9631 punct -,like
R5899 T9633 T9629 punct ", ",structures
R5900 T9634 T9635 advmod instead,of
R5901 T9635 T9629 prep of,structures
R5902 T9636 T9637 det a,ribbon
R5903 T9637 T9635 pobj ribbon,of
R5904 T9638 T9637 amod singule,ribbon
R5905 T9639 T9625 punct .,appeared
R5906 T9641 T9642 prep For,contained
R5907 T9643 T9641 pobj example,For
R5908 T9644 T9642 punct ", ",contained
R5909 T9645 T9646 nmod terminal,1
R5910 T9646 T9642 nsubj 1,contained
R5911 T9647 T9646 cc and,1
R5912 T9648 T9646 conj 2,1
R5913 T9649 T9650 nummod two,ribbons
R5914 T9650 T9642 dobj ribbons,contained
R5915 T9651 T9650 appos each,ribbons
R5916 T9652 T9642 punct ", ",contained
R5917 T9653 T9654 mark whereas,appeared
R5918 T9654 T9642 advcl appeared,contained
R5919 T9655 T9654 nsubj terminal,appeared
R5920 T9656 T9655 nummod 3,terminal
R5921 T9657 T9658 aux to,contain
R5922 T9658 T9654 xcomp contain,appeared
R5923 T9659 T9660 advmod only,one
R5924 T9660 T9658 dobj one,contain
R5925 T9661 T9642 punct .,contained
R5926 T9664 T9663 punct ", ",opl
R5927 T9665 T9666 amod outer,layer
R5928 T9666 T9663 appos layer,opl
R5929 T9667 T9666 compound plexiform,layer
R5930 T9668 T9663 punct .,opl
R5931 T9670 T9671 compound Scale,bar
R5932 T9671 T9672 nsubj bar,μm
R5933 T9673 T9672 punct =,μm
R5934 T9674 T9672 nummod 2,μm
R5935 T9675 T9672 punct .,μm
R5938 T9811 T9812 compound Transmission,micrographs
R5939 T9813 T9812 compound electron,micrographs
R5940 T9814 T9812 prep of,micrographs
R5941 T9815 T9816 det the,layer
R5942 T9816 T9814 pobj layer,of
R5943 T9817 T9818 amod outer,plexiform
R5944 T9818 T9816 compound plexiform,layer
R5945 T9819 T9812 prep in,micrographs
R5946 T9820 T9821 nmod Crx,retinas
R5947 T9821 T9819 pobj retinas,in
R5948 T9822 T9820 punct -,Crx
R5949 T9823 T9820 punct /,Crx
R5950 T9824 T9820 punct -,Crx
R5951 T9825 T9812 prep at,micrographs
R5952 T9826 T9825 pobj P21,at
R5953 T9827 T9812 punct .,micrographs
R5954 T9829 T9830 punct (,A
R5955 T9830 T9831 meta A,contained
R5956 T9832 T9830 punct ),A
R5957 T9833 T9834 nmod Crx,spherules
R5958 T9834 T9831 nsubj spherules,contained
R5959 T9835 T9833 punct +,Crx
R5960 T9836 T9833 punct /,Crx
R5961 T9837 T9833 punct +,Crx
R5962 T9838 T9834 compound rod,spherules
R5963 T9839 T9840 det a,synapse
R5964 T9840 T9831 dobj synapse,contained
R5965 T9841 T9840 amod single,synapse
R5966 T9842 T9840 amod invaginating,synapse
R5967 T9843 T9840 prep with,synapse
R5968 T9844 T9845 nummod one,complex
R5969 T9845 T9843 pobj complex,with
R5970 T9846 T9845 compound ribbon,complex
R5971 T9847 T9831 punct .,contained
R5972 T9849 T9850 det The,spherule
R5973 T9850 T9851 nsubj spherule,was
R5974 T9852 T9853 det a,structure
R5975 T9853 T9851 attr structure,was
R5976 T9854 T9853 amod blunt,structure
R5977 T9855 T9854 cc or,blunt
R5978 T9856 T9857 npadvmod club,shaped
R5979 T9857 T9854 conj shaped,blunt
R5980 T9858 T9857 punct -,shaped
R5981 T9859 T9851 punct .,was
R5982 T9861 T9862 punct (,B
R5983 T9862 T9863 meta B,contained
R5984 T9864 T9862 punct ),B
R5985 T9865 T9866 nmod Crx,terminals
R5986 T9866 T9863 nsubj terminals,contained
R5987 T9867 T9865 punct +,Crx
R5988 T9868 T9865 punct /,Crx
R5989 T9869 T9865 punct +,Crx
R5990 T9870 T9866 compound rod,terminals
R5991 T9871 T9872 det a,structure
R5992 T9872 T9863 dobj structure,contained
R5993 T9873 T9872 amod single,structure
R5994 T9874 T9872 compound ribbon,structure
R5995 T9875 T9872 punct (,structure
R5996 T9876 T9872 appos r,structure
R5997 T9877 T9863 punct ),contained
R5998 T9878 T9863 punct .,contained
R5999 T9880 T9881 nummod Two,processes
R6000 T9881 T9882 nsubj processes,contacted
R6001 T9883 T9881 punct ", ",processes
R6002 T9884 T9881 prep from,processes
R6003 T9885 T9886 amod horizontal,cells
R6004 T9886 T9884 pobj cells,from
R6005 T9887 T9886 punct (,cells
R6006 T9888 T9886 appos h,cells
R6007 T9889 T9882 punct ),contacted
R6008 T9890 T9882 punct ", ",contacted
R6009 T9891 T9892 det the,rod
R6010 T9892 T9882 dobj rod,contacted
R6011 T9893 T9882 advmod laterally,contacted
R6012 T9894 T9882 punct .,contacted
R6013 T9896 T9897 det An,process
R6014 T9897 T9899 nsubjpass process,situated
R6015 T9898 T9897 amod additional,process
R6016 T9900 T9897 punct ", ",process
R6017 T9901 T9902 det the,dendrite
R6018 T9902 T9897 appos dendrite,process
R6019 T9903 T9902 amod postsynaptic,dendrite
R6020 T9904 T9902 amod bipolar,dendrite
R6021 T9905 T9902 punct (,dendrite
R6022 T9906 T9902 appos b,dendrite
R6023 T9907 T9899 punct ),situated
R6024 T9908 T9899 punct ", ",situated
R6025 T9909 T9899 auxpass was,situated
R6026 T9910 T9911 advmod more,centrally
R6027 T9911 T9899 advmod centrally,situated
R6028 T9912 T9899 punct .,situated
R6029 T9914 T9915 nsubjpass Terminals,filled
R6030 T9916 T9915 auxpass were,filled
R6031 T9917 T9915 prep with,filled
R6032 T9918 T9919 amod synaptic,vesicles
R6033 T9919 T9917 pobj vesicles,with
R6034 T9920 T9915 punct .,filled
R6035 T9922 T9923 nummod One,vesicle
R6036 T9923 T9925 nsubjpass vesicle,observed
R6037 T9924 T9923 amod coated,vesicle
R6038 T9926 T9923 acl originatinf,vesicle
R6039 T9927 T9926 prep from,originatinf
R6040 T9928 T9929 det the,membrane
R6041 T9929 T9927 pobj membrane,from
R6042 T9930 T9929 compound cell,membrane
R6043 T9931 T9925 auxpass was,observed
R6044 T9932 T9933 punct (,arrow
R6045 T9933 T9925 parataxis arrow,observed
R6046 T9934 T9933 punct ),arrow
R6047 T9935 T9925 punct .,observed
R6048 T9937 T9938 punct (,C
R6049 T9938 T9939 meta C,appeared
R6050 T9940 T9938 punct ),C
R6051 T9941 T9939 prep In,appeared
R6052 T9942 T9943 det the,OPL
R6053 T9943 T9941 pobj OPL,In
R6054 T9944 T9943 prep of,OPL
R6055 T9945 T9946 nmod Crx,retinas
R6056 T9946 T9944 pobj retinas,of
R6057 T9947 T9945 punct -,Crx
R6058 T9948 T9945 punct /,Crx
R6059 T9949 T9945 punct -,Crx
R6060 T9950 T9939 punct ", ",appeared
R6061 T9951 T9952 compound photoreceptor,terminals
R6062 T9952 T9939 nsubj terminals,appeared
R6063 T9953 T9954 advmod highly,disorganized
R6064 T9954 T9939 oprd disorganized,appeared
R6065 T9955 T9939 punct .,appeared
R6066 T9957 T9958 amod Putative,terminals
R6067 T9958 T9959 nsubj terminals,were
R6068 T9960 T9958 acl containing,terminals
R6069 T9961 T9962 amod synaptic,vesicles
R6070 T9962 T9960 dobj vesicles,containing
R6071 T9963 T9962 cc and,vesicles
R6072 T9964 T9965 npadvmod ribbon,like
R6073 T9965 T9967 amod like,structures
R6074 T9966 T9965 punct -,like
R6075 T9967 T9962 conj structures,vesicles
R6076 T9968 T9959 acomp apparent,were
R6077 T9969 T9970 punct (,arrows
R6078 T9970 T9959 parataxis arrows,were
R6079 T9971 T9970 punct ),arrows
R6080 T9972 T9959 punct ", ",were
R6081 T9973 T9959 advcl suggesting,were
R6082 T9974 T9975 advmod at,least
R6083 T9975 T9976 advmod least,limited
R6084 T9976 T9977 amod limited,generation
R6085 T9977 T9973 dobj generation,suggesting
R6086 T9978 T9977 prep of,generation
R6087 T9979 T9980 compound synapse,components
R6088 T9980 T9978 pobj components,of
R6089 T9981 T9959 punct .,were
R6090 T9983 T9984 advmod However,observed
R6091 T9985 T9984 punct ", ",observed
R6092 T9986 T9987 advmod well,formed
R6093 T9987 T9988 amod formed,spherules
R6094 T9988 T9984 nsubjpass spherules,observed
R6095 T9989 T9988 cc and,spherules
R6096 T9990 T9988 conj pedicles,spherules
R6097 T9991 T9984 auxpass were,observed
R6098 T9992 T9984 neg not,observed
R6099 T9993 T9984 punct .,observed
R6100 T9995 T9996 advmod Further,appeared
R6101 T9997 T9996 punct ", ",appeared
R6102 T9998 T9999 amod many,terminals
R6103 T9999 T9996 nsubj terminals,appeared
R6104 T10000 T10001 aux to,contain
R6105 T10001 T9996 xcomp contain,appeared
R6106 T10002 T10003 amod multiple,structures
R6107 T10003 T10001 dobj structures,contain
R6108 T10004 T10005 npadvmod ribbon,like
R6109 T10005 T10003 amod like,structures
R6110 T10006 T10005 punct -,like
R6111 T10007 T10003 punct (,structures
R6112 T10008 T10003 appos r,structures
R6113 T10009 T9996 punct ),appeared
R6114 T10010 T9996 punct .,appeared
R6115 T10012 T10013 det The,majority
R6116 T10013 T10014 nsubjpass majority,associated
R6117 T10015 T10013 prep of,majority
R6118 T10016 T10017 det these,ribbons
R6119 T10017 T10015 pobj ribbons,of
R6120 T10018 T10014 auxpass were,associated
R6121 T10019 T10014 neg not,associated
R6122 T10020 T10014 prep with,associated
R6123 T10021 T10022 det the,membrane
R6124 T10022 T10020 pobj membrane,with
R6125 T10023 T10022 amod synaptic,membrane
R6126 T10024 T10014 punct ", ",associated
R6127 T10025 T10014 cc but,associated
R6128 T10026 T10025 advmod instead,but
R6129 T10027 T10028 auxpass were,found
R6130 T10028 T10014 conj found,associated
R6131 T10029 T10030 amod free,floating
R6132 T10030 T10028 advcl floating,found
R6133 T10031 T10028 cc and,found
R6134 T10032 T10028 punct ", ",found
R6135 T10033 T10034 prep in,were
R6136 T10034 T10028 conj were,found
R6137 T10035 T10036 det some,instances
R6138 T10036 T10033 pobj instances,in
R6139 T10037 T10034 punct ", ",were
R6140 T10038 T10034 acomp perinuclear,were
R6141 T10039 T10040 punct (,arrow
R6142 T10040 T10034 parataxis arrow,were
R6143 T10041 T10040 dep D,arrow
R6144 T10042 T10040 punct ", ",arrow
R6145 T10043 T10040 punct ),arrow
R6146 T10044 T10014 punct .,associated
R6147 T10047 T10046 punct ", ",H
R6148 T10048 T10049 amod horizontal,cell
R6149 T10049 T10046 appos cell,H
R6150 T10050 T10046 punct ;,H
R6151 T10051 T10046 appos B,H
R6152 T10052 T10051 punct ", ",B
R6153 T10053 T10054 amod bipolar,cell
R6154 T10054 T10051 appos cell,B
R6155 T10055 T10046 punct ;,H
R6156 T10056 T10046 appos N,H
R6157 T10057 T10056 punct ", ",N
R6158 T10058 T10056 appos nucleus,N
R6159 T10059 T10046 punct ;,H
R6160 T10060 T10046 appos r,H
R6161 T10061 T10060 punct ", ",r
R6162 T10062 T10060 appos ribbon,r
R6163 T10063 T10046 punct .,H
R6164 T10065 T10066 punct (,A
R6165 T10066 T10067 meta A,nm
R6166 T10067 T10073 ccomp nm,nm
R6167 T10068 T10066 punct ),A
R6168 T10069 T10070 compound Scale,bar
R6169 T10070 T10067 nsubj bar,nm
R6170 T10071 T10067 punct =,nm
R6171 T10072 T10067 nummod 500,nm
R6172 T10074 T10073 punct ", ",nm
R6173 T10075 T10076 punct (,B
R6174 T10076 T10077 meta B,nm
R6175 T10077 T10073 ccomp nm,nm
R6176 T10078 T10076 punct ),B
R6177 T10079 T10080 compound Scale,bar
R6178 T10080 T10077 nsubj bar,nm
R6179 T10081 T10077 punct =,nm
R6180 T10082 T10077 nummod 250,nm
R6181 T10083 T10073 punct ", ",nm
R6182 T10084 T10085 punct (,C
R6183 T10085 T10073 meta C,nm
R6184 T10086 T10085 cc and,C
R6185 T10087 T10085 conj D,C
R6186 T10088 T10087 punct ),D
R6187 T10089 T10090 compound Scale,bar
R6188 T10090 T10073 nsubj bar,nm
R6189 T10091 T10073 punct =,nm
R6190 T10092 T10073 nummod 500,nm
R6191 T10093 T10073 punct .,nm
R149 T283 T280 nsubj photoreceptors,demonstrated
R925 T1606 T1604 pobj presence,by
R1348 T2590 T2591 compound ceptor,i
R1349 T2601 T2600 parataxis nd,a
R1350 T2607 T2608 amod r,segments
R1351 T2611 T2610 amod ar,e
R1352 T2615 T2614 agent by,joined
R1353 T2616 T2617 det a,cilium
R1354 T2617 T2615 pobj cilium,by
R1355 T2618 T2617 amod non-motile,cilium
R1356 T2619 T2617 amod connecting,cilium
R1357 T2620 T2621 dep that,exhibits
R1358 T2621 T2617 relcl exhibits,cilium
R1359 T2622 T2623 det a,arrangement
R1360 T2623 T2621 dobj arrangement,exhibits
R1361 T2624 T2623 amod characteristic,arrangement
R1362 T2625 T2626 nummod 9,0
R1363 T2626 T2623 nummod 0,arrangement
R1364 T2627 T2626 punct +,0
R1365 T2628 T2623 prep of,arrangement
R1366 T2629 T2630 compound microtubule,doublets
R1367 T2630 T2628 pobj doublets,of
R1368 T2631 T2632 advmod when,viewed
R1369 T2632 T2621 advcl viewed,exhibits
R1370 T2633 T2632 prep in,viewed
R1371 T2634 T2633 pobj cross-section,in
R1372 T2635 T2614 punct .,joined
R1373 T2637 T2638 prep At,noted
R1374 T2639 T2637 pobj P21,At
R1375 T2640 T2638 punct ", ",noted
R1376 T2641 T2638 prep in,noted
R1377 T2642 T2643 nmod Crx,retinas
R1378 T2643 T2641 pobj retinas,in
R1379 T2644 T2642 punct -,Crx
R1380 T2645 T2642 punct /,Crx
R1381 T2646 T2642 punct -,Crx
R1382 T2647 T2638 punct ", ",noted
R1383 T2648 T2649 amod numerous,sections
R1384 T2649 T2638 nsubjpass sections,noted
R1385 T2650 T2649 compound cross,sections
R1386 T2651 T2649 prep of,sections
R1387 T2652 T2653 amod connecting,cilia
R1388 T2653 T2651 pobj cilia,of
R1468 T2741 T2739 pobj photoreceptors,in
R1471 T2744 T2740 punct -,Crx
R1472 T2745 T2725 punct .,indicate
R1473 T2747 T2748 advmod Further,appeared
R1474 T2749 T2748 punct ", ",appeared
R1475 T2750 T2748 prep in,appeared
R1476 T2751 T2752 nmod Crx,retinas
R1477 T2752 T2750 pobj retinas,in
R1478 T2753 T2751 punct -,Crx
R1479 T2754 T2751 punct /,Crx
R1480 T2755 T2751 punct -,Crx
R1481 T2756 T2757 det the,epithelium
R1482 T2757 T2748 nsubj epithelium,appeared
R1483 T2758 T2757 nmod retinal,epithelium
R1484 T2759 T2757 amod pigmented,epithelium
R1485 T2760 T2757 punct (,epithelium
R1486 T2761 T2757 appos PE,epithelium
R1487 T2762 T2748 punct ),appeared
R1488 T2763 T2748 oprd normal,appeared
R1489 T2764 T2748 punct ", ",appeared
R1490 T2765 T2766 advmod at,least
R1491 T2766 T2767 advmod least,up
R1492 T2767 T2748 prep up,appeared
R1493 T2768 T2767 prep to,up
R1494 T2769 T2768 pobj P21,to
R1495 T2770 T2771 punct (,shown
R1496 T2771 T2769 parataxis shown,P21
R1497 T2772 T2771 nsubj data,shown
R1498 T2773 T2771 neg not,shown
R1499 T2774 T2771 punct ),shown
R1500 T2775 T2769 punct ", ",P21
R1501 T2776 T2777 det the,age
R1502 T2777 T2769 appos age,P21
R1503 T2778 T2777 amod oldest,age
R1504 T2779 T2777 acl examined,age
R1505 T2780 T2748 punct .,appeared
R1506 T2787 T2786 oprd ti,i
R1507 T2788 T2789 amod o,n
R1508 T2792 T2791 pobj t,o
R1509 T2796 T2795 parataxis o,c
R1510 T2801 T2802 compound e,t
R1511 T2804 T2805 compound e,a
R1512 T2807 T2808 amod bs,e
R1513 T2814 T2812 advcl o,o
R1514 T2817 T2818 amod uter,segments
R1515 T2819 T2816 punct ", ",exhibited
R1516 T2820 T2821 nmod Crx,retinas
R1517 T2821 T2816 nsubj retinas,exhibited
R1518 T2822 T2820 punct -,Crx
R1519 T2823 T2820 punct /,Crx
R1520 T2824 T2820 punct -,Crx
R1521 T2825 T2826 nummod three,pathologies
R1522 T2826 T2816 dobj pathologies,exhibited
R1523 T2827 T2826 amod other,pathologies
R1524 T2828 T2826 amod notable,pathologies
R1525 T2829 T2816 prep in,exhibited
R1526 T2830 T2831 det the,layer
R1527 T2831 T2829 pobj layer,in
R1528 T2832 T2833 amod outer,segment
R1529 T2833 T2831 compound segment,layer
R1530 T2834 T2816 punct .,exhibited
R1531 T2836 T2837 advmod First,noted
R1532 T2838 T2837 punct ", ",noted
R1533 T2839 T2840 det an,deposition
R1534 T2840 T2837 nsubjpass deposition,noted
R1535 T2841 T2840 amod abnormal,deposition
R1536 T2842 T2840 prep of,deposition
R1537 T2843 T2842 pobj matrix,of
R1538 T2844 T2843 prep of,matrix
R1539 T2845 T2846 amod unknown,identity
R1540 T2846 T2844 pobj identity,of
R1541 T2847 T2837 auxpass was,noted
R1971 T3310 T3308 pobj formation,of
R1973 T3311 T3312 amod outer,segment
R1976 T3312 T3310 compound segment,formation
R1979 T3313 T3306 prep in,absence
R1983 T3314 T3315 det the,mouse
R1986 T3315 T3313 pobj mouse,in
R1987 T3316 T3315 compound Crx,mouse
R1989 T3317 T3315 compound mutant,mouse
R1993 T3318 T3306 punct ", ",absence
R1997 T3319 T3306 cc and,absence
R2001 T3320 T3321 det the,arrest
R2002 T3321 T3306 conj arrest,absence
R2003 T3322 T3321 prep of,arrest
R2004 T3323 T3322 pobj development,of
R2007 T3324 T3323 prep of,development
R2010 T3325 T3326 det the,appendage
R2014 T3326 T3324 pobj appendage,of
R2018 T3327 T3326 compound photoreceptor,appendage
R2022 T3328 T3321 prep at,arrest
R2028 T3329 T3330 det the,stage
R2033 T3330 T3328 pobj stage,at
R2036 T3331 T3330 compound elongation,stage
R2040 T3332 T3330 prep of,stage
R2042 T3333 T3334 amod outer,segment
R2046 T3334 T3335 compound segment,formation
R2049 T3335 T3332 pobj formation,of
R2053 T3336 T3304 punct .,demonstrate
R1964 T3356 T3355 prep o,ph
R1972 T3367 T3368 det the,photoreceptors
R1974 T3368 T3366 pobj photoreceptors,f
R1975 T3369 T3368 amod malformed,photoreceptors
R1977 T3370 T3368 nmod Crx,photoreceptors
R1978 T3371 T3370 punct -,Crx
R1980 T3372 T3370 punct /,Crx
R1981 T3373 T3370 punct -,Crx
R1982 T3374 T3365 auxpass was,compared
R1984 T3375 T3365 prep to,compared
R1985 T3376 T3377 nmod rhodopsin,photoreceptors