PMC:546330 / 159-1307 JSONTXT

{"project":"Biotea","denotations":[{"id":"T2","span":{"begin":41,"end":46},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14220"},{"id":"T3","span":{"begin":470,"end":475},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14220"},{"id":"T4","span":{"begin":756,"end":761},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14220"},{"id":"T6","span":{"begin":41,"end":46},"obj":"http://purl.bioontology.org/ontology/MESH/D015497"},{"id":"T7","span":{"begin":470,"end":475},"obj":"http://purl.bioontology.org/ontology/MESH/D015497"},{"id":"T8","span":{"begin":756,"end":761},"obj":"http://purl.bioontology.org/ontology/MESH/D015497"},{"id":"T10","span":{"begin":4,"end":32},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14219"},{"id":"T11","span":{"begin":41,"end":44},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14219"},{"id":"T12","span":{"begin":470,"end":473},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14219"},{"id":"T13","span":{"begin":756,"end":759},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14219"},{"id":"T15","span":{"begin":41,"end":44},"obj":"http://purl.bioontology.org/ontology/MESH/D006678"},{"id":"T16","span":{"begin":470,"end":473},"obj":"http://purl.bioontology.org/ontology/MESH/D006678"},{"id":"T17","span":{"begin":756,"end":759},"obj":"http://purl.bioontology.org/ontology/MESH/D006678"},{"id":"T19","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_P04694"},{"id":"T20","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_P04694"},{"id":"T21","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_P04694"},{"id":"T22","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_P04694"},{"id":"T24","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_000016089"},{"id":"T25","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_000016089"},{"id":"T26","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_000016089"},{"id":"T27","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_000016089"},{"id":"T29","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_000032034"},{"id":"T30","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_000032034"},{"id":"T31","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_000032034"},{"id":"T32","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_000032034"},{"id":"T34","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_Q8QZR1"},{"id":"T35","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_Q8QZR1"},{"id":"T36","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_Q8QZR1"},{"id":"T37","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_Q8QZR1"},{"id":"T39","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_Q54K95"},{"id":"T40","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_Q54K95"},{"id":"T41","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_Q54K95"},{"id":"T42","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_Q54K95"},{"id":"T44","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_Q6MG11"},{"id":"T45","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_Q6MG11"},{"id":"T46","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_Q6MG11"},{"id":"T47","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_Q6MG11"},{"id":"T49","span":{"begin":71,"end":74},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116443"},{"id":"T50","span":{"begin":221,"end":224},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116443"},{"id":"T51","span":{"begin":385,"end":388},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116443"},{"id":"T52","span":{"begin":592,"end":595},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116443"},{"id":"T54","span":{"begin":71,"end":74},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106574"},{"id":"T55","span":{"begin":221,"end":224},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106574"},{"id":"T56","span":{"begin":385,"end":388},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106574"},{"id":"T57","span":{"begin":592,"end":595},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106574"},{"id":"T59","span":{"begin":71,"end":74},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94843"},{"id":"T60","span":{"begin":221,"end":224},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94843"},{"id":"T61","span":{"begin":385,"end":388},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94843"},{"id":"T62","span":{"begin":592,"end":595},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94843"},{"id":"T64","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_Q8K341"},{"id":"T65","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_Q8K341"},{"id":"T66","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_Q8K341"},{"id":"T67","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_Q8K341"},{"id":"T69","span":{"begin":71,"end":74},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154151"},{"id":"T70","span":{"begin":221,"end":224},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154151"},{"id":"T71","span":{"begin":385,"end":388},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154151"},{"id":"T72","span":{"begin":592,"end":595},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154151"},{"id":"T74","span":{"begin":71,"end":74},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17186"},{"id":"T75","span":{"begin":221,"end":224},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17186"},{"id":"T76","span":{"begin":385,"end":388},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17186"},{"id":"T77","span":{"begin":592,"end":595},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17186"},{"id":"T79","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_Q6PH17"},{"id":"T80","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_Q6PH17"},{"id":"T81","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_Q6PH17"},{"id":"T82","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_Q6PH17"},{"id":"T84","span":{"begin":71,"end":74},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16619"},{"id":"T85","span":{"begin":221,"end":224},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16619"},{"id":"T86","span":{"begin":385,"end":388},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16619"},{"id":"T87","span":{"begin":592,"end":595},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16619"},{"id":"T89","span":{"begin":71,"end":74},"obj":"http://purl.obolibrary.org/obo/PR_Q9LVY1"},{"id":"T90","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/PR_Q9LVY1"},{"id":"T91","span":{"begin":385,"end":388},"obj":"http://purl.obolibrary.org/obo/PR_Q9LVY1"},{"id":"T92","span":{"begin":592,"end":595},"obj":"http://purl.obolibrary.org/obo/PR_Q9LVY1"},{"id":"T94","span":{"begin":89,"end":104},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17208"},{"id":"T95","span":{"begin":245,"end":258},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17208"},{"id":"T96","span":{"begin":669,"end":682},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17208"},{"id":"T97","span":{"begin":1036,"end":1049},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17208"},{"id":"T99","span":{"begin":245,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T100","span":{"begin":669,"end":682},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T101","span":{"begin":1036,"end":1049},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T103","span":{"begin":245,"end":258},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142497"},{"id":"T104","span":{"begin":669,"end":682},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142497"},{"id":"T105","span":{"begin":1036,"end":1049},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142497"},{"id":"T107","span":{"begin":259,"end":266},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/103360007"},{"id":"T109","span":{"begin":259,"end":266},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19398"},{"id":"T111","span":{"begin":259,"end":266},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47881"},{"id":"T113","span":{"begin":259,"end":266},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157677"},{"id":"T115","span":{"begin":259,"end":266},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C134028"},{"id":"T117","span":{"begin":272,"end":280},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52474"},{"id":"T118","span":{"begin":416,"end":424},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52474"},{"id":"T119","span":{"begin":841,"end":849},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52474"},{"id":"T121","span":{"begin":272,"end":280},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63548"},{"id":"T122","span":{"begin":416,"end":424},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63548"},{"id":"T123","span":{"begin":841,"end":849},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63548"},{"id":"T125","span":{"begin":272,"end":280},"obj":"http://purl.obolibrary.org/obo/SO_0001248"},{"id":"T126","span":{"begin":416,"end":424},"obj":"http://purl.obolibrary.org/obo/SO_0001248"},{"id":"T127","span":{"begin":841,"end":849},"obj":"http://purl.obolibrary.org/obo/SO_0001248"},{"id":"T131","span":{"begin":548,"end":551},"obj":"http://purl.obolibrary.org/obo/PR_P17871"},{"id":"T132","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/PR_P17871"},{"id":"T133","span":{"begin":869,"end":872},"obj":"http://purl.obolibrary.org/obo/PR_P17871"},{"id":"T134","span":{"begin":983,"end":986},"obj":"http://purl.obolibrary.org/obo/PR_P17871"},{"id":"T136","span":{"begin":548,"end":551},"obj":"http://purl.obolibrary.org/obo/PR_Q9YGV8"},{"id":"T137","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/PR_Q9YGV8"},{"id":"T138","span":{"begin":869,"end":872},"obj":"http://purl.obolibrary.org/obo/PR_Q9YGV8"},{"id":"T139","span":{"begin":983,"end":986},"obj":"http://purl.obolibrary.org/obo/PR_Q9YGV8"},{"id":"T141","span":{"begin":548,"end":551},"obj":"http://purl.obolibrary.org/obo/PR_P26355"},{"id":"T142","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/PR_P26355"},{"id":"T143","span":{"begin":869,"end":872},"obj":"http://purl.obolibrary.org/obo/PR_P26355"},{"id":"T144","span":{"begin":983,"end":986},"obj":"http://purl.obolibrary.org/obo/PR_P26355"},{"id":"T146","span":{"begin":522,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_000016137"},{"id":"T147","span":{"begin":548,"end":551},"obj":"http://purl.obolibrary.org/obo/PR_000016137"},{"id":"T148","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/PR_000016137"},{"id":"T149","span":{"begin":869,"end":872},"obj":"http://purl.obolibrary.org/obo/PR_000016137"},{"id":"T150","span":{"begin":983,"end":986},"obj":"http://purl.obolibrary.org/obo/PR_000016137"},{"id":"T152","span":{"begin":548,"end":551},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20460"},{"id":"T153","span":{"begin":561,"end":564},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20460"},{"id":"T154","span":{"begin":869,"end":872},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20460"},{"id":"T155","span":{"begin":983,"end":986},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20460"},{"id":"T157","span":{"begin":548,"end":551},"obj":"http://purl.bioontology.org/ontology/MESH/C009524"},{"id":"T158","span":{"begin":561,"end":564},"obj":"http://purl.bioontology.org/ontology/MESH/C009524"},{"id":"T159","span":{"begin":869,"end":872},"obj":"http://purl.bioontology.org/ontology/MESH/C009524"},{"id":"T160","span":{"begin":983,"end":986},"obj":"http://purl.bioontology.org/ontology/MESH/C009524"},{"id":"T162","span":{"begin":548,"end":551},"obj":"http://purl.obolibrary.org/obo/PR_P13393"},{"id":"T163","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/PR_P13393"},{"id":"T164","span":{"begin":869,"end":872},"obj":"http://purl.obolibrary.org/obo/PR_P13393"},{"id":"T165","span":{"begin":983,"end":986},"obj":"http://purl.obolibrary.org/obo/PR_P13393"},{"id":"T167","span":{"begin":548,"end":551},"obj":"http://purl.obolibrary.org/obo/PR_O43133"},{"id":"T168","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/PR_O43133"},{"id":"T169","span":{"begin":869,"end":872},"obj":"http://purl.obolibrary.org/obo/PR_O43133"},{"id":"T170","span":{"begin":983,"end":986},"obj":"http://purl.obolibrary.org/obo/PR_O43133"},{"id":"T172","span":{"begin":548,"end":551},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52514"},{"id":"T173","span":{"begin":561,"end":564},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52514"},{"id":"T174","span":{"begin":869,"end":872},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52514"},{"id":"T175","span":{"begin":983,"end":986},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52514"},{"id":"T177","span":{"begin":548,"end":551},"obj":"http://purl.obolibrary.org/obo/PR_P32085"},{"id":"T178","span":{"begin":561,"end":564},"obj":"http://purl.obolibrary.org/obo/PR_P32085"},{"id":"T179","span":{"begin":869,"end":872},"obj":"http://purl.obolibrary.org/obo/PR_P32085"},{"id":"T180","span":{"begin":983,"end":986},"obj":"http://purl.obolibrary.org/obo/PR_P32085"},{"id":"T182","span":{"begin":522,"end":546},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17578"},{"id":"T183","span":{"begin":548,"end":551},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17578"},{"id":"T184","span":{"begin":561,"end":564},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17578"},{"id":"T185","span":{"begin":869,"end":872},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17578"},{"id":"T186","span":{"begin":983,"end":986},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17578"},{"id":"T188","span":{"begin":994,"end":1001},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/418560003"},{"id":"T189","span":{"begin":1130,"end":1137},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/418560003"},{"id":"T190","span":{"begin":4,"end":39},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/89293008"},{"id":"T191","span":{"begin":4,"end":32},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0019682"},{"id":"T192","span":{"begin":4,"end":32},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/19030005"},{"id":"T193","span":{"begin":4,"end":32},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/72621000119104"},{"id":"T194","span":{"begin":4,"end":9},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14225"},{"id":"T195","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T196","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T197","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T198","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T199","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T200","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T201","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T202","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T203","span":{"begin":4,"end":9},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T204","span":{"begin":4,"end":9},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T205","span":{"begin":4,"end":9},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T206","span":{"begin":10,"end":26},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3131"},{"id":"T207","span":{"begin":10,"end":26},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39725"},{"id":"T208","span":{"begin":10,"end":26},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10061598"},{"id":"T209","span":{"begin":10,"end":26},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU007447"},{"id":"T210","span":{"begin":27,"end":37},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/277234002"},{"id":"T211","span":{"begin":27,"end":37},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/246256003"},{"id":"T212","span":{"begin":27,"end":32},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T213","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/49872002"},{"id":"T214","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T215","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T216","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T217","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T218","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T219","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T220","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T221","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T222","span":{"begin":27,"end":32},"obj":"http://purl.bioontology.org/ontology/STY/T005"},{"id":"T223","span":{"begin":27,"end":32},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14283"},{"id":"T224","span":{"begin":33,"end":37},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/410656007"},{"id":"T225","span":{"begin":33,"end":37},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25284"},{"id":"T226","span":{"begin":48,"end":70},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38537"},{"id":"T227","span":{"begin":63,"end":70},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64858"},{"id":"T228","span":{"begin":539,"end":546},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64858"},{"id":"T229","span":{"begin":1053,"end":1060},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64858"},{"id":"T230","span":{"begin":63,"end":70},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T231","span":{"begin":539,"end":546},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T232","span":{"begin":1053,"end":1060},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T233","span":{"begin":63,"end":70},"obj":"http://purl.obolibrary.org/obo/GO_0003675"},{"id":"T234","span":{"begin":539,"end":546},"obj":"http://purl.obolibrary.org/obo/GO_0003675"},{"id":"T235","span":{"begin":1053,"end":1060},"obj":"http://purl.obolibrary.org/obo/GO_0003675"},{"id":"T236","span":{"begin":63,"end":70},"obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"T237","span":{"begin":539,"end":546},"obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"T238","span":{"begin":1053,"end":1060},"obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"T239","span":{"begin":63,"end":70},"obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"T240","span":{"begin":539,"end":546},"obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"T241","span":{"begin":1053,"end":1060},"obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"T242","span":{"begin":63,"end":70},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000148318"},{"id":"T243","span":{"begin":539,"end":546},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000148318"},{"id":"T244","span":{"begin":1053,"end":1060},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000148318"},{"id":"T245","span":{"begin":63,"end":70},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T246","span":{"begin":539,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T247","span":{"begin":1053,"end":1060},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T248","span":{"begin":63,"end":70},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T249","span":{"begin":539,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T250","span":{"begin":1053,"end":1060},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T251","span":{"begin":63,"end":70},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41172"},{"id":"T252","span":{"begin":539,"end":546},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41172"},{"id":"T253","span":{"begin":1053,"end":1060},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41172"},{"id":"T254","span":{"begin":63,"end":70},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/88878007"},{"id":"T255","span":{"begin":539,"end":546},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/88878007"},{"id":"T256","span":{"begin":1053,"end":1060},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/88878007"},{"id":"T257","span":{"begin":63,"end":70},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10036987"},{"id":"T258","span":{"begin":539,"end":546},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10036987"},{"id":"T259","span":{"begin":1053,"end":1060},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10036987"},{"id":"T260","span":{"begin":81,"end":88},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77967"},{"id":"T261","span":{"begin":89,"end":114},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18526"},{"id":"T262","span":{"begin":105,"end":114},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154897"},{"id":"T263","span":{"begin":148,"end":157},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61391"},{"id":"T264","span":{"begin":158,"end":175},"obj":"http://purl.bioontology.org/ontology/MESH/D012319"},{"id":"T265","span":{"begin":158,"end":175},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/116739004"},{"id":"T266","span":{"begin":158,"end":175},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95948"},{"id":"T267","span":{"begin":158,"end":172},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91427"},{"id":"T268","span":{"begin":158,"end":172},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20076"},{"id":"T269","span":{"begin":158,"end":161},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132301"},{"id":"T270","span":{"begin":786,"end":789},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132301"},{"id":"T271","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/GO_0005562"},{"id":"T272","span":{"begin":786,"end":789},"obj":"http://purl.obolibrary.org/obo/GO_0005562"},{"id":"T273","span":{"begin":158,"end":161},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C812"},{"id":"T274","span":{"begin":786,"end":789},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C812"},{"id":"T275","span":{"begin":158,"end":161},"obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"T276","span":{"begin":786,"end":789},"obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"T277","span":{"begin":158,"end":161},"obj":"http://purl.bioontology.org/ontology/MESH/D012313"},{"id":"T278","span":{"begin":786,"end":789},"obj":"http://purl.bioontology.org/ontology/MESH/D012313"},{"id":"T279","span":{"begin":158,"end":161},"obj":"http://purl.obolibrary.org/obo/PR_000023786"},{"id":"T280","span":{"begin":786,"end":789},"obj":"http://purl.obolibrary.org/obo/PR_000023786"},{"id":"T281","span":{"begin":162,"end":172},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20636"},{"id":"T282","span":{"begin":198,"end":203},"obj":"http://purl.obolibrary.org/obo/OBI_0000073"},{"id":"T283","span":{"begin":198,"end":203},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/224699009"},{"id":"T284","span":{"begin":198,"end":203},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45319"},{"id":"T285","span":{"begin":198,"end":203},"obj":"http://purl.obolibrary.org/obo/OBI_0000066"},{"id":"T286","span":{"begin":198,"end":203},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63537"},{"id":"T287","span":{"begin":198,"end":203},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15206"},{"id":"T288","span":{"begin":198,"end":203},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63536"},{"id":"T289","span":{"begin":208,"end":217},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50285"},{"id":"T290","span":{"begin":208,"end":217},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25343"},{"id":"T291","span":{"begin":208,"end":217},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/278109006"},{"id":"T292","span":{"begin":225,"end":231},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/129264002"},{"id":"T293","span":{"begin":225,"end":231},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25404"},{"id":"T294","span":{"begin":225,"end":231},"obj":"http://www.owl-ontologies.com/Ontology1184060740.owl#Class_89"},{"id":"T295","span":{"begin":281,"end":288},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15744"},{"id":"T296","span":{"begin":295,"end":324},"obj":"http://purl.bioontology.org/ontology/MESH/D047369"},{"id":"T297","span":{"begin":295,"end":324},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C106048"},{"id":"T298","span":{"begin":295,"end":324},"obj":"http://purl.obolibrary.org/obo/OBI_00001975"},{"id":"T299","span":{"begin":295,"end":304},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/60085001"},{"id":"T300","span":{"begin":295,"end":304},"obj":"http://purl.obolibrary.org/obo/GO_0000785"},{"id":"T301","span":{"begin":295,"end":304},"obj":"http://purl.obolibrary.org/obo/GO_0000785"},{"id":"T302","span":{"begin":295,"end":304},"obj":"http://purl.bioontology.org/ontology/MESH/D002843"},{"id":"T303","span":{"begin":295,"end":304},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13201"},{"id":"T304","span":{"begin":295,"end":304},"obj":"http://purl.org/sig/ont/fma/fma67526"},{"id":"T305","span":{"begin":295,"end":304},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000169072"},{"id":"T306","span":{"begin":305,"end":324},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16724"},{"id":"T307","span":{"begin":305,"end":324},"obj":"http://purl.obolibrary.org/obo/OBI_0000690"},{"id":"T308","span":{"begin":305,"end":324},"obj":"http://purl.bioontology.org/ontology/MESH/D047468"},{"id":"T309","span":{"begin":336,"end":340},"obj":"http://purl.obolibrary.org/obo/PR_000016389"},{"id":"T310","span":{"begin":366,"end":373},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102843"},{"id":"T311","span":{"begin":456,"end":462},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/35810008"},{"id":"T312","span":{"begin":476,"end":496},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13251"},{"id":"T313","span":{"begin":476,"end":480},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25248"},{"id":"T314","span":{"begin":476,"end":480},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/255511005"},{"id":"T315","span":{"begin":476,"end":480},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU015091"},{"id":"T316","span":{"begin":476,"end":480},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48311"},{"id":"T317","span":{"begin":481,"end":489},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50216"},{"id":"T318","span":{"begin":481,"end":489},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47940"},{"id":"T319","span":{"begin":490,"end":496},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47886"},{"id":"T320","span":{"begin":490,"end":496},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/27582007"},{"id":"T321","span":{"begin":490,"end":496},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48804"},{"id":"T322","span":{"begin":490,"end":496},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47942"},{"id":"T323","span":{"begin":500,"end":508},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25428"},{"id":"T324","span":{"begin":500,"end":508},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/112231000"},{"id":"T325","span":{"begin":500,"end":508},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C9478"},{"id":"T326","span":{"begin":522,"end":526},"obj":"http://purl.obolibrary.org/obo/PR_000024028"},{"id":"T327","span":{"begin":527,"end":530},"obj":"http://purl.bioontology.org/ontology/NDDF/ZB"},{"id":"T328","span":{"begin":527,"end":530},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/415183006"},{"id":"T329","span":{"begin":527,"end":530},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43178"},{"id":"T330","span":{"begin":527,"end":530},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48478"},{"id":"T331","span":{"begin":531,"end":546},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17728"},{"id":"T332","span":{"begin":531,"end":546},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/304372009"},{"id":"T333","span":{"begin":531,"end":538},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T334","span":{"begin":531,"end":538},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/257768005"},{"id":"T335","span":{"begin":531,"end":538},"obj":"http://purl.obolibrary.org/obo/OBI_0001588"},{"id":"T336","span":{"begin":531,"end":538},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82888"},{"id":"T337","span":{"begin":531,"end":538},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18219"},{"id":"T338","span":{"begin":565,"end":575},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25281"},{"id":"T339","span":{"begin":596,"end":604},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25518"},{"id":"T340","span":{"begin":596,"end":604},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/277064003"},{"id":"T341","span":{"begin":596,"end":604},"obj":"http://purl.bioontology.org/ontology/MESH/Q000502"},{"id":"T342","span":{"begin":596,"end":604},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/246464006"},{"id":"T343","span":{"begin":596,"end":604},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54025"},{"id":"T344","span":{"begin":596,"end":604},"obj":"http://purl.obolibrary.org/obo/BFO_0000034"},{"id":"T345","span":{"begin":614,"end":620},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/255589003"},{"id":"T346","span":{"begin":614,"end":620},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62254"},{"id":"T347","span":{"begin":621,"end":632},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54216"},{"id":"T348","span":{"begin":621,"end":632},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54708"},{"id":"T349","span":{"begin":642,"end":650},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111153"},{"id":"T350","span":{"begin":946,"end":954},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C111153"},{"id":"T351","span":{"begin":642,"end":650},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12508"},{"id":"T352","span":{"begin":946,"end":954},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12508"},{"id":"T353","span":{"begin":1030,"end":1035},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12508"},{"id":"T354","span":{"begin":651,"end":659},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61304"},{"id":"T355","span":{"begin":651,"end":659},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61511"},{"id":"T356","span":{"begin":660,"end":702},"obj":"http://purl.bioontology.org/ontology/MESH/D042925"},{"id":"T357","span":{"begin":660,"end":702},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000169820"},{"id":"T358","span":{"begin":660,"end":668},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C113772"},{"id":"T359","span":{"begin":660,"end":668},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81172"},{"id":"T360","span":{"begin":660,"end":668},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25246"},{"id":"T361","span":{"begin":660,"end":668},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/10828004"},{"id":"T362","span":{"begin":660,"end":668},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38758"},{"id":"T363","span":{"begin":669,"end":702},"obj":"http://purl.obolibrary.org/obo/PR_000000045"},{"id":"T364","span":{"begin":669,"end":693},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28586"},{"id":"T365","span":{"begin":683,"end":700},"obj":"http://purl.bioontology.org/ontology/MESH/D010445"},{"id":"T366","span":{"begin":694,"end":700},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25506"},{"id":"T367","span":{"begin":694,"end":700},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84380"},{"id":"T368","span":{"begin":713,"end":723},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61464"},{"id":"T369","span":{"begin":713,"end":723},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/71967004"},{"id":"T370","span":{"begin":762,"end":770},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13297"},{"id":"T371","span":{"begin":771,"end":774},"obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"T372","span":{"begin":771,"end":774},"obj":"http://purl.obolibrary.org/obo/GO_0005574"},{"id":"T373","span":{"begin":771,"end":774},"obj":"http://purl.bioontology.org/ontology/MESH/D004247"},{"id":"T374","span":{"begin":771,"end":774},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C135409"},{"id":"T375","span":{"begin":771,"end":774},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C449"},{"id":"T376","span":{"begin":815,"end":826},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25657"},{"id":"T377","span":{"begin":894,"end":899},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25430"},{"id":"T378","span":{"begin":894,"end":899},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000021972"},{"id":"T379","span":{"begin":908,"end":915},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61036"},{"id":"T380","span":{"begin":908,"end":915},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76124"},{"id":"T381","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T382","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T383","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T384","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T385","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T386","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T387","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T388","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T389","span":{"begin":908,"end":915},"obj":"http://purl.bioontology.org/ontology/STY/T033"},{"id":"T390","span":{"begin":908,"end":915},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3367"},{"id":"T391","span":{"begin":936,"end":945},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63905"},{"id":"T392","span":{"begin":936,"end":945},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78344"},{"id":"T393","span":{"begin":936,"end":945},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131934"},{"id":"T394","span":{"begin":936,"end":945},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131954"},{"id":"T395","span":{"begin":936,"end":945},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/371154000"},{"id":"T396","span":{"begin":936,"end":945},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C131948"},{"id":"T397","span":{"begin":1020,"end":1029},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14234"},{"id":"T398","span":{"begin":1030,"end":1035},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48938"},{"id":"T399","span":{"begin":1030,"end":1035},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000184307"},{"id":"T400","span":{"begin":1030,"end":1035},"obj":"http://purl.bioontology.org/ontology/MESH/D002477"},{"id":"T401","span":{"begin":1053,"end":1067},"obj":"http://purl.obolibrary.org/obo/SO_0000010"},{"id":"T402","span":{"begin":1061,"end":1067},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120363"},{"id":"T403","span":{"begin":1061,"end":1067},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120360"},{"id":"T404","span":{"begin":1061,"end":1067},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80216"},{"id":"T405","span":{"begin":1061,"end":1067},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45971"},{"id":"T406","span":{"begin":1068,"end":1073},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612"},{"id":"T407","span":{"begin":1068,"end":1073},"obj":"http://purl.bioontology.org/ontology/MESH/D005796"},{"id":"T408","span":{"begin":1083,"end":1094},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25415"},{"id":"T409","span":{"begin":1118,"end":1126},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/386397008"},{"id":"T410","span":{"begin":1118,"end":1126},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25626"},{"id":"T411","span":{"begin":1118,"end":1126},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/705057003"}],"namespaces":[{"prefix":"omim","uri":"http://purl.bioontology.org/ontology/OMIM/"},{"prefix":"pr","uri":"http://purl.obolibrary.org/obo/PR_"}],"text":"The human immunodeficiency virus type I (HIV-1) transactivator protein Tat is an unusual transcriptional activator that is thought to act solely by promoting RNA polymerase II processivity. Here we study the mechanism of Tat action by analyzing transcription complex (TC) assembly in vivo using chromatin immunoprecipitation assays. We find, unexpectedly, that like typical activators Tat dramatically stimulates TC assembly. Surprisingly, however, the TC formed on the HIV-1 long terminal repeat is atypical and contains TATA-box-binding protein (TBP) but not TBP-associated factors (TAFs). Tat function involves direct interaction with the cellular cofactor positive transcription elongation factor b (P-TEFb). Artificial tethering of P-TEFb subunits to HIV-1 promoter DNA or nascent RNA indicates that P-TEFb is responsible for directing assembly of a TC containing TBP but not TAFs. On the basis of this finding, we identify P-TEFb-dependent cellular promoters that also recruit TBP in the absence of TAFs. Thus, in mammalian cells transcription of protein-coding genes involves alternative TCs that differ by the presence or absence of TAFs.\n\n"}