PMC:546184 / 9755-11965 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/546184","sourcedb":"PMC","sourceid":"546184","source_url":"http://www.ncbi.nlm.nih.gov/pmc/546184","text":"Patients\nIn all studies, patients were 18 years of age or older and met criteria for MDD as defined by the Diagnostic and Statistical Manual of Mental Disorders, 4thEdition (DSM-IV) [43]. The diagnosis of MDD was confirmed by the Mini International Neuropsychiatric Interview (MINI) [44], a standardized diagnostic interview based on DSM-IV criteria. Patients had a 17-item Hamilton Rating Scale for Depression (HAMD17)[45] total score ≥ 15 and a Clinical Global Impression of Severity (CGI-S)[46] score ≥ 4 at the screening and second study visits. The presence of melancholic features (DSM-IV criteria) was determined using results from the MINI:\n\"Either feature 1 or 2 in Criteria A AND three (or more) features from Criteria B must be present to qualify for melancholic features.\nA. Either of the following, occurring during the most severe period of the current episode.\n1. Loss of pleasure in all, or almost all, activities;\n2. Lack of reactivity to usually pleasurable stimuli\nB. Three (or more) of the following:\n1. Distinct quality of depressed mood;\n2. Depression regularly worse in the morning;\n3. Early morning awakening (at least 2 hours before usual time of awakening);\n4. Marked psychomotor retardation or agitation;\n5. Significant anorexia or weight loss;\n6. Excessive or inappropriate guilt.\"\nPatients were excluded for the following reasons: a current and primary Axis I disorder, other than MDD; an Axis II disorder which could interfere with protocol compliance; lack of response of the current depressive episode to two or more adequate courses of antidepressant therapy; serious medical illness; a serious risk of suicide; a history of substance abuse or dependence within the last year, or a positive urine drug screen.\nConcomitant medications with primarily central nervous system activity were not permitted, with the exception of episodic use of chloral hydrate or zolpidem for insomnia. Chronic use of prescription analgesic medications was not allowed; episodic use was permitted at the discretion of the physician in charge of the study. Use of anti-hypertensive medications was not permitted unless the patient had been on a stable dose for at least 3 months prior to study entry.","divisions":[{"label":"Title","span":{"begin":0,"end":8}}],"tracks":[{"project":"2_test","denotations":[{"id":"15631624-9881538-13857387","span":{"begin":284,"end":286},"obj":"9881538"},{"id":"15631624-14399272-13857388","span":{"begin":420,"end":422},"obj":"14399272"}],"attributes":[{"subj":"15631624-9881538-13857387","pred":"source","obj":"2_test"},{"subj":"15631624-14399272-13857388","pred":"source","obj":"2_test"}]},{"project":"NEUROSES","denotations":[{"id":"T203","span":{"begin":51,"end":54},"obj":"PATO_0000011"},{"id":"T204","span":{"begin":51,"end":54},"obj":"CHEBI_84123"},{"id":"T205","span":{"begin":68,"end":71},"obj":"CHEBI_16044"},{"id":"T206","span":{"begin":68,"end":71},"obj":"CHEBI_16811"},{"id":"T207","span":{"begin":68,"end":71},"obj":"CHEBI_16643"},{"id":"T208","span":{"begin":85,"end":88},"obj":"CHEBI_566274"},{"id":"T209","span":{"begin":205,"end":208},"obj":"CHEBI_566274"},{"id":"T210","span":{"begin":1410,"end":1413},"obj":"CHEBI_566274"},{"id":"T211","span":{"begin":174,"end":177},"obj":"CHEBI_38624"},{"id":"T212","span":{"begin":334,"end":337},"obj":"CHEBI_38624"},{"id":"T213","span":{"begin":588,"end":591},"obj":"CHEBI_38624"},{"id":"T214","span":{"begin":554,"end":562},"obj":"PATO_0000070"},{"id":"T215","span":{"begin":739,"end":746},"obj":"PATO_0000467"},{"id":"T216","span":{"begin":1164,"end":1168},"obj":"PATO_0001309"},{"id":"T217","span":{"begin":1024,"end":1032},"obj":"PATO_0000463"},{"id":"T218","span":{"begin":1033,"end":1040},"obj":"PATO_0000001"},{"id":"T219","span":{"begin":1109,"end":1114},"obj":"PATO_0000694"},{"id":"T220","span":{"begin":1164,"end":1168},"obj":"PATO_0000165"},{"id":"T221","span":{"begin":1187,"end":1193},"obj":"PATO_0000465"},{"id":"T222","span":{"begin":1259,"end":1265},"obj":"PATO_0000128"},{"id":"T223","span":{"begin":1549,"end":1557},"obj":"PATO_0001627"},{"id":"T224","span":{"begin":1569,"end":1583},"obj":"CHEBI_35469"},{"id":"T225","span":{"begin":1658,"end":1667},"obj":"PATO_0000142"},{"id":"T226","span":{"begin":1730,"end":1734},"obj":"CHEBI_23888"},{"id":"T227","span":{"begin":1856,"end":1864},"obj":"PATO_0002530"},{"id":"T228","span":{"begin":1981,"end":1989},"obj":"PATO_0002530"},{"id":"T229","span":{"begin":1891,"end":1899},"obj":"CHEBI_10125"},{"id":"T230","span":{"begin":1904,"end":1912},"obj":"PATO_0000442"},{"id":"T231","span":{"begin":1914,"end":1921},"obj":"PATO_0000498"},{"id":"T232","span":{"begin":1914,"end":1921},"obj":"PATO_0001863"},{"id":"T233","span":{"begin":1942,"end":1951},"obj":"CHEBI_35480"},{"id":"T234","span":{"begin":400,"end":410},"obj":"PM3425"},{"id":"T235","span":{"begin":1063,"end":1073},"obj":"PM3425"},{"id":"T236","span":{"begin":400,"end":410},"obj":"PM3425"},{"id":"T237","span":{"begin":1063,"end":1073},"obj":"PM3425"}],"attributes":[{"subj":"T203","pred":"source","obj":"NEUROSES"},{"subj":"T204","pred":"source","obj":"NEUROSES"},{"subj":"T205","pred":"source","obj":"NEUROSES"},{"subj":"T206","pred":"source","obj":"NEUROSES"},{"subj":"T207","pred":"source","obj":"NEUROSES"},{"subj":"T208","pred":"source","obj":"NEUROSES"},{"subj":"T209","pred":"source","obj":"NEUROSES"},{"subj":"T210","pred":"source","obj":"NEUROSES"},{"subj":"T211","pred":"source","obj":"NEUROSES"},{"subj":"T212","pred":"source","obj":"NEUROSES"},{"subj":"T213","pred":"source","obj":"NEUROSES"},{"subj":"T214","pred":"source","obj":"NEUROSES"},{"subj":"T215","pred":"source","obj":"NEUROSES"},{"subj":"T216","pred":"source","obj":"NEUROSES"},{"subj":"T217","pred":"source","obj":"NEUROSES"},{"subj":"T218","pred":"source","obj":"NEUROSES"},{"subj":"T219","pred":"source","obj":"NEUROSES"},{"subj":"T220","pred":"source","obj":"NEUROSES"},{"subj":"T221","pred":"source","obj":"NEUROSES"},{"subj":"T222","pred":"source","obj":"NEUROSES"},{"subj":"T223","pred":"source","obj":"NEUROSES"},{"subj":"T224","pred":"source","obj":"NEUROSES"},{"subj":"T225","pred":"source","obj":"NEUROSES"},{"subj":"T226","pred":"source","obj":"NEUROSES"},{"subj":"T227","pred":"source","obj":"NEUROSES"},{"subj":"T228","pred":"source","obj":"NEUROSES"},{"subj":"T229","pred":"source","obj":"NEUROSES"},{"subj":"T230","pred":"source","obj":"NEUROSES"},{"subj":"T231","pred":"source","obj":"NEUROSES"},{"subj":"T232","pred":"source","obj":"NEUROSES"},{"subj":"T233","pred":"source","obj":"NEUROSES"},{"subj":"T234","pred":"source","obj":"NEUROSES"},{"subj":"T235","pred":"source","obj":"NEUROSES"},{"subj":"T236","pred":"source","obj":"NEUROSES"},{"subj":"T237","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecd4","default":true},{"id":"NEUROSES","color":"#ecba93"}]}]}}