PMC:546184 / 1521-2673 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/546184","sourcedb":"PMC","sourceid":"546184","source_url":"http://www.ncbi.nlm.nih.gov/pmc/546184","text":"Results\nIn data from all 8 studies, duloxetine's advantage over placebo did not differ significantly between melancholic and non-melancholic patients (treatment-by-melancholic status interactions were not statistically significant). Duloxetine demonstrated significantly greater improvement in depressive symptom severity, compared with placebo, within both melancholic and non-melancholic cohorts (p ≤ .001 for HAMD17 total score, CGI-S and PGI-I). When analyzed by gender, the magnitude of improvement in efficacy outcomes did not differ significantly between duloxetine-treated male and female melancholic patients. In the two studies that assessed duloxetine 60 mg once-daily dosing, duloxetine-treated melancholic patients had significantly greater improvement compared with placebo on HAMD17 total score, CGI-S, PGI-I, 3 of 4 subscales of the HAMD17, and VAS overall pain severity (p \u003c .01). Estimated probabilities of response and remission were significantly greater for melancholic patients receiving duloxetine 60 mg QD compared with placebo (response 74.7% vs. 42.2%, respectively, p \u003c .001; remission 44.4% vs. 24.7%, respectively, p = .002","divisions":[{"label":"Title","span":{"begin":0,"end":7}}],"tracks":[{"project":"NEUROSES","denotations":[{"id":"T29","span":{"begin":36,"end":46},"obj":"CHEBI_36796"},{"id":"T30","span":{"begin":233,"end":243},"obj":"CHEBI_36796"},{"id":"T31","span":{"begin":562,"end":572},"obj":"CHEBI_36796"},{"id":"T32","span":{"begin":652,"end":662},"obj":"CHEBI_36796"},{"id":"T33","span":{"begin":688,"end":698},"obj":"CHEBI_36796"},{"id":"T34","span":{"begin":1010,"end":1020},"obj":"CHEBI_36796"},{"id":"T47","span":{"begin":442,"end":445},"obj":"CHEBI_26345"},{"id":"T48","span":{"begin":818,"end":821},"obj":"CHEBI_26345"},{"id":"T50","span":{"begin":72,"end":75},"obj":"CHEBI_52027"},{"id":"T51","span":{"begin":525,"end":528},"obj":"CHEBI_52027"},{"id":"T53","span":{"begin":479,"end":488},"obj":"PATO_0002016"},{"id":"T54","span":{"begin":581,"end":585},"obj":"PATO_0000384"},{"id":"T55","span":{"begin":581,"end":585},"obj":"CHEBI_30780"},{"id":"T56","span":{"begin":590,"end":596},"obj":"PATO_0000383"}],"attributes":[{"subj":"T29","pred":"source","obj":"NEUROSES"},{"subj":"T30","pred":"source","obj":"NEUROSES"},{"subj":"T31","pred":"source","obj":"NEUROSES"},{"subj":"T32","pred":"source","obj":"NEUROSES"},{"subj":"T33","pred":"source","obj":"NEUROSES"},{"subj":"T34","pred":"source","obj":"NEUROSES"},{"subj":"T47","pred":"source","obj":"NEUROSES"},{"subj":"T48","pred":"source","obj":"NEUROSES"},{"subj":"T50","pred":"source","obj":"NEUROSES"},{"subj":"T51","pred":"source","obj":"NEUROSES"},{"subj":"T53","pred":"source","obj":"NEUROSES"},{"subj":"T54","pred":"source","obj":"NEUROSES"},{"subj":"T55","pred":"source","obj":"NEUROSES"},{"subj":"T56","pred":"source","obj":"NEUROSES"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#ecca93","default":true}]}]}}