PMC:540021 / 6157-6905 JSONTXT

{"project":"2_test","denotations":[{"id":"15608176-11734650-77178217","span":{"begin":524,"end":526},"obj":"11734650"}],"text":"Rate shifting sites\nSites in a protein evolve at different rates, with some functionally constrained sites evolving slowly and some others evolving faster. Some sites also evolve at different rates in different subfamilies of a family. Sites with such shifts in evolutionary rates between two subfamilies are referred to as RSS. Detecting a large number of such positions between two subfamilies suggests that the function has diverged between them. RSS between subfamilies in a family were determined using the LRT method (13). Each position in the alignment is analyzed individually and the program generates U-values that specify the likelihood that there is a rate change for each alignment position between the subfamilies under consideration."}