PMC:5400020 / 7363-13723 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5400020","sourcedb":"PMC","sourceid":"5400020","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5400020","text":"RESULTS\nFive hundred patients have been enrolled in the SAVI-1 and SAVI-2 registries. The patient flow is displayed in ure 1. In SAVI-1, approximately 70% of centres were first-time users, and 15 (58%) new centres were included in SAVI-2. No centre enrolled more than 15% of patients. The centre list is provided in the Supplementary Material, Table S1.\nFigure 1: Patient flow diagram.\nBaseline and procedural characteristics are displayed in Table 1. Risk scores were slightly lower in the SAVI-1 compared to the SAVI-2 cohort (Logistic EuroSCORE-I of 22.3 ± 12.7% vs 24.7 ± 15.7%).\nTable 1: Baseline and procedural characteristics\nSAVI-1 SAVI-2 Total\nn = 250 n = 250 n = 500\nBaseline\n  Age [years] 80.9 ± 6.3 80.7 ± 5.9 80.8 ± 6.1\n  Male 126 (50.8)a 104 (41.6) 230 (46.2)\n  Logistic EuroSCORE-I [%] 22.3 ± 12.7 24.7 ± 15.7 23.4 ± 14.3\n  STS Score [%] 8.0 ± 5.9 11.9 ± 10.0 9.8 ± 8.3\nProcedure\n  Prior balloon valvuloplasty 240 (97.2)b 218 (87.2) 458 (92.2)\n  Device sizes used\n   S 84 (33.6) 68 (27.2) 152 (30.4)\n   M 93 (37.2) 109 (43.6) 202 (40.4)\n   L 73 (29.2) 73 (29.2) 146 (29.2)\n  Deployment under rapid pacing 176 (71.3)b 9 (3.6) 185 (37.0)\n  Post-dilatation 97 (38.8) 110 (44.0) 207 (41.4)\nProcedure\n  Successful implant 245 (98.0) 241 (96.4) 489 (97.8)\n  Valve-in-valve procedure 2 (0.8) 6 (2.4) 8 (1.6)\n  Conversion to surgery 3 (1.2) 0 3 (0.6)\nData are presented as mean ± SD or n (%). NA: not assessed. aunknown in two patients, bunknown in three patients.\nOf all 500 procedures, in SAVI-1 and SAVI-2, implantation of the ACURATE TA valve was successful in 489 (97.8%) patients. In SAVI-1, 3 conversions to open-heart surgery occurred (1 intraprocedural event when the device was pulled into the left ventricle during delivery system withdrawal, 1 on post-procedure day 1 for severe aortic regurgitation, and another on day 7 for severe aortic regurgitation after tilted valve deployment). Two valve-in-valve procedures using another commercially available transcatheter heart valve were performed for severe aortic regurgitation. In SAVI-2, no conversion to open heart occurred, but 6 valve-in-valve procedures (of these, 1 was associated with coronary obstruction, 2 with valve migration 1 with coronary obstruction and valve migration), 1 unplanned use of cardiopulmonary bypass and 1 mitral valve apparatus damage/dysfunction. Both patients with coronary obstruction and valve-in-valve procedure were diagnosed with porcelain aorta at baseline.\nEchocardiographic parameters were similar between the registries, with slightly less paravalvular leakage ≥2+ at 1 year in SAVI-2 (0.8% vs 4.1%) (Table 2, Fig. 2). The NYHA classification improved from 93.5% of patients in NYHA class III/IV at baseline to 13.0% at 1 year (Fig. 3, Supplementary Material, Table S2).\nFigure 2: Echocardiographic parameters over time (SAVI-1 and SAVI-2). (A) Aortic valve haemodynamics, measured as mean gradient and effective orifice area (EOA), and (B) percentage of patients with paravalvular leakage. Values remained stable between early follow-up at discharge/30 days and 1 year.\nFigure 3: New York Heart Association (NYHA) classification at baseline and follow-up (SAVI-1 and SAVI-2).\nTable 2: Echocardiographic assessments\nSAVI-1 SAVI-2 Total\nn = 250 n =  250 n =  500\nBaseline\n  Effective orifice area [mm2] 0.71 ± 0.21 0.75 ± 0.31 0.73 ± 0.26\n  Mean gradient [mmHg] 43.1 ± 17.4 42.2 ± 14.9 42.7 ± 16.2\nn =  219 n =  203 n =  422\n30 days Discharge/7-daysa\n  Effective orifice area 1.44 ± 0.45 1.48 ± 0.43 1.45 ± 0.44\n  Mean gradient [mmHg] 12.4 ± 5.8 12.5 ± 6.0 12.5 ± 5.9\n  Paravalvular leak\n   0: non/trace 159 (72.6) 141 (69.5) 300 (71.1)\n   1+: mild 55 (25.1) 59 (29.1) 114 (27.0)\n   2+: moderate 5 (2.3) 3 (1.5) 8 (1.9)\n   3+: moderate/severe 0 0 0\n   4+: severe 0 0 0\n1 year n = 148 n = 126 n = 274\n  Effective orifice area 1.51 ± 0.38 1.57 ± 0.40 1.54 ± 0.39\n  Mean gradient 12.9 ± 5.3 11.1 ± 4.4 12.1 ± 5.0\n  Paravalvular leak\n   0: non/trace 111 (75.0) 80 (63.5) 191 (69.7)\n   1+: mild 31 (20.9) 45 (35.7) 76 (27.7)\n   2+: moderate 5 (3.4) 1 (0.8) 6 (2.2)\n   3+: moderate/severe 1 (0.7) 0 1 (0.4)\n   4+: severe 0 0 0\nData are presented as mean ± SD or n (%). Not all measurements were available for all patients displayed,.\na whichever was earlier.\nRelevant safety outcomes are displayed in Table 3, and additional outcomes in Supplementary Material, Table S3. Notably, only SAVI-2 outcomes were categorized by VARC-2 criteria. In general, outcomes were similar between SAVI-1 and SAVI-2. Mortality at 30 days was 6.4% [95% CI: 3.3–9.4] for SAVI-1 and 7.2% [95% CI:3.9–10.4] for SAVI-2, and at 1 year 18.9% [95% CI:13.9–23.7] and 20.8% [95% CI:15.6–25.8] respectively, P = 0.64 (Fig. 4).\nFigure 4: All-cause mortality per Kaplan–Meier estimate.\nTable 3: Kaplan–Meier estimates of relevant clinical outcomes at 30 days and 1 year\nSAVI-1a SAVI-2 Total HR\n30 days\n  Mortality 16 (6.4) [3.3–9.4] 18 (7.2) [3.9–10.4] 34 (6.8) [4.6–9.0] 1.12 (0.57:2.2)\n   Cardiovascular 5 (2.0) [0.3–3.8] 9 (3.6) [1.3–5.9] 14 (2.8) [1.4–4.3] 1.80 (0.60:5.37)\n   Non-cardiovascular 11 (4.5) [1.9–7.0] 9 (3.7) [1.3–6.0] 20 (4.1) [2.3–5.8] 0.82 (0.34:2.00)\n  Strokeb 7 (2.9) [0.8–4.9] 4 (1.6) [0.0–3.2] 11 (2.2) [0.9–3.5] 0.57 (0.17:1.95)\n  Myocardial infarction 1 (0.4) [0.0–2.0] 1 (0.4) [0.0–1.2] 2 (0.4) [0.0–1.0] 1.00 (0.06:15.99)\n  AKI stage 3 NA 7 (2.8) [0.7–4.9] – NA\n  Other TAVI-related complications post-discharge 0 0 0 NA\n  New onset of atrial fibrillation/atrial flutter NA 20 (8.2) [4.7–11.5] – NA\n  Permanent pacemaker 25 (10.2) [6.3–14.0] 25 (10.2) [6.3–13.9] 50 (10.2) [7.5–12.9] 1.01 (0.58:1.76)\n1 year n = 241 n = 243 n = 484\n  Mortality 47 (18.9) [13.9–23.7] 51 (20.8) [15.6–25.8] 98 (19.9) [16.3–23.3] 1.10 (0.74:1.64)\n   Cardiovascular 15 (6.4) [3.2–9.4] 19 (8.2) [4.5–11.6] 34 (7.3) [4.9–9.6] 1.31 (0.66:2.57)\n   Non-cardiovascular 32 (13.2) [8.9–17.4] 32 (13.8) [9.2–18.1] 64 (13.5) [10.4–16.5] 1.02 (0.62:1.66)\n  Stroke 10 (4.2) [1.6–6.7] 7 (3.2) [0.8–5.5] 17 (3.7) [1.9–5.4] 0.72 (0.27:1.89)\n  Other TAVI-related complications post-discharge 0 0 0 NA\nData are presented as n (%) [95% CI], and HR. AKI-acute kidney injury, HR-hazard ratio, calculated using the Cox proportional hazards regression analysis, NA-not assessed, TAVI-transcatheter aortic valve implantation, ano VARC classification, bnot further specified if disabling or not disabling.","divisions":[{"label":"title","span":{"begin":0,"end":7}},{"label":"p","span":{"begin":8,"end":385}},{"label":"figure","span":{"begin":354,"end":385}},{"label":"label","span":{"begin":354,"end":363}},{"label":"caption","span":{"begin":364,"end":385}},{"label":"p","span":{"begin":364,"end":385}},{"label":"p","span":{"begin":386,"end":1471}},{"label":"table-wrap","span":{"begin":584,"end":1471}},{"label":"label","span":{"begin":584,"end":592}},{"label":"caption","span":{"begin":593,"end":632}},{"label":"p","span":{"begin":593,"end":632}},{"label":"table","span":{"begin":633,"end":1357}},{"label":"tr","span":{"begin":633,"end":652}},{"label":"th","span":{"begin":633,"end":639}},{"label":"th","span":{"begin":640,"end":646}},{"label":"th","span":{"begin":647,"end":652}},{"label":"tr","span":{"begin":653,"end":676}},{"label":"th","span":{"begin":653,"end":660}},{"label":"th","span":{"begin":661,"end":668}},{"label":"th","span":{"begin":669,"end":676}},{"label":"tr","span":{"begin":677,"end":685}},{"label":"td","span":{"begin":677,"end":685}},{"label":"tr","span":{"begin":686,"end":732}},{"label":"td","span":{"begin":686,"end":699}},{"label":"td","span":{"begin":700,"end":710}},{"label":"td","span":{"begin":711,"end":721}},{"label":"td","span":{"begin":722,"end":732}},{"label":"tr","span":{"begin":733,"end":773}},{"label":"td","span":{"begin":733,"end":739}},{"label":"td","span":{"begin":740,"end":751}},{"label":"td","span":{"begin":752,"end":762}},{"label":"td","span":{"begin":763,"end":773}},{"label":"tr","span":{"begin":774,"end":836}},{"label":"td","span":{"begin":774,"end":800}},{"label":"td","span":{"begin":801,"end":812}},{"label":"td","span":{"begin":813,"end":824}},{"label":"td","span":{"begin":825,"end":836}},{"label":"tr","span":{"begin":837,"end":884}},{"label":"td","span":{"begin":837,"end":852}},{"label":"td","span":{"begin":853,"end":862}},{"label":"td","span":{"begin":863,"end":874}},{"label":"td","span":{"begin":875,"end":884}},{"label":"tr","span":{"begin":885,"end":894}},{"label":"td","span":{"begin":885,"end":894}},{"label":"tr","span":{"begin":895,"end":958}},{"label":"td","span":{"begin":895,"end":924}},{"label":"td","span":{"begin":925,"end":936}},{"label":"td","span":{"begin":937,"end":947}},{"label":"td","span":{"begin":948,"end":958}},{"label":"tr","span":{"begin":959,"end":978}},{"label":"td","span":{"begin":959,"end":978}},{"label":"tr","span":{"begin":979,"end":1014}},{"label":"td","span":{"begin":979,"end":983}},{"label":"td","span":{"begin":984,"end":993}},{"label":"td","span":{"begin":994,"end":1003}},{"label":"td","span":{"begin":1004,"end":1014}},{"label":"tr","span":{"begin":1015,"end":1051}},{"label":"td","span":{"begin":1015,"end":1019}},{"label":"td","span":{"begin":1020,"end":1029}},{"label":"td","span":{"begin":1030,"end":1040}},{"label":"td","span":{"begin":1041,"end":1051}},{"label":"tr","span":{"begin":1052,"end":1087}},{"label":"td","span":{"begin":1052,"end":1056}},{"label":"td","span":{"begin":1057,"end":1066}},{"label":"td","span":{"begin":1067,"end":1076}},{"label":"td","span":{"begin":1077,"end":1087}},{"label":"tr","span":{"begin":1088,"end":1150}},{"label":"td","span":{"begin":1088,"end":1119}},{"label":"td","span":{"begin":1120,"end":1131}},{"label":"td","span":{"begin":1132,"end":1139}},{"label":"td","span":{"begin":1140,"end":1150}},{"label":"tr","span":{"begin":1151,"end":1200}},{"label":"td","span":{"begin":1151,"end":1168}},{"label":"td","span":{"begin":1169,"end":1178}},{"label":"td","span":{"begin":1179,"end":1189}},{"label":"td","span":{"begin":1190,"end":1200}},{"label":"tr","span":{"begin":1201,"end":1210}},{"label":"td","span":{"begin":1201,"end":1210}},{"label":"tr","span":{"begin":1211,"end":1264}},{"label":"td","span":{"begin":1211,"end":1231}},{"label":"td","span":{"begin":1232,"end":1242}},{"label":"td","span":{"begin":1243,"end":1253}},{"label":"td","span":{"begin":1254,"end":1264}},{"label":"tr","span":{"begin":1265,"end":1315}},{"label":"td","span":{"begin":1265,"end":1291}},{"label":"td","span":{"begin":1292,"end":1299}},{"label":"td","span":{"begin":1300,"end":1307}},{"label":"td","span":{"begin":1308,"end":1315}},{"label":"tr","span":{"begin":1316,"end":1357}},{"label":"td","span":{"begin":1316,"end":1339}},{"label":"td","span":{"begin":1340,"end":1347}},{"label":"td","span":{"begin":1348,"end":1349}},{"label":"td","span":{"begin":1350,"end":1357}},{"label":"table-wrap-foot","span":{"begin":1358,"end":1471}},{"label":"footnote","span":{"begin":1358,"end":1471}},{"label":"p","span":{"begin":1358,"end":1471}},{"label":"p","span":{"begin":1472,"end":2463}},{"label":"p","span":{"begin":2464,"end":4260}},{"label":"figure","span":{"begin":2780,"end":3079}},{"label":"label","span":{"begin":2780,"end":2789}},{"label":"caption","span":{"begin":2790,"end":3079}},{"label":"p","span":{"begin":2790,"end":3079}},{"label":"figure","span":{"begin":3080,"end":3185}},{"label":"label","span":{"begin":3080,"end":3089}},{"label":"caption","span":{"begin":3090,"end":3185}},{"label":"p","span":{"begin":3090,"end":3185}},{"label":"table-wrap","span":{"begin":3186,"end":4260}},{"label":"label","span":{"begin":3186,"end":3194}},{"label":"caption","span":{"begin":3195,"end":3224}},{"label":"p","span":{"begin":3195,"end":3224}},{"label":"table","span":{"begin":3225,"end":4128}},{"label":"tr","span":{"begin":3225,"end":3244}},{"label":"th","span":{"begin":3225,"end":3231}},{"label":"th","span":{"begin":3232,"end":3238}},{"label":"th","span":{"begin":3239,"end":3244}},{"label":"tr","span":{"begin":3245,"end":3270}},{"label":"th","span":{"begin":3245,"end":3252}},{"label":"th","span":{"begin":3253,"end":3261}},{"label":"th","span":{"begin":3262,"end":3270}},{"label":"tr","span":{"begin":3271,"end":3279}},{"label":"td","span":{"begin":3271,"end":3279}},{"label":"tr","span":{"begin":3280,"end":3346}},{"label":"td","span":{"begin":3280,"end":3310}},{"label":"td","span":{"begin":3311,"end":3322}},{"label":"td","span":{"begin":3323,"end":3334}},{"label":"td","span":{"begin":3335,"end":3346}},{"label":"tr","span":{"begin":3347,"end":3405}},{"label":"td","span":{"begin":3347,"end":3369}},{"label":"td","span":{"begin":3370,"end":3381}},{"label":"td","span":{"begin":3382,"end":3393}},{"label":"td","span":{"begin":3394,"end":3405}},{"label":"tr","span":{"begin":3406,"end":3432}},{"label":"td","span":{"begin":3406,"end":3414}},{"label":"td","span":{"begin":3415,"end":3423}},{"label":"td","span":{"begin":3424,"end":3432}},{"label":"tr","span":{"begin":3433,"end":3458}},{"label":"td","span":{"begin":3433,"end":3440}},{"label":"td","span":{"begin":3441,"end":3458}},{"label":"tr","span":{"begin":3459,"end":3519}},{"label":"td","span":{"begin":3459,"end":3483}},{"label":"td","span":{"begin":3484,"end":3495}},{"label":"td","span":{"begin":3496,"end":3507}},{"label":"td","span":{"begin":3508,"end":3519}},{"label":"tr","span":{"begin":3520,"end":3575}},{"label":"td","span":{"begin":3520,"end":3542}},{"label":"td","span":{"begin":3543,"end":3553}},{"label":"td","span":{"begin":3554,"end":3564}},{"label":"td","span":{"begin":3565,"end":3575}},{"label":"tr","span":{"begin":3576,"end":3595}},{"label":"td","span":{"begin":3576,"end":3595}},{"label":"tr","span":{"begin":3596,"end":3644}},{"label":"td","span":{"begin":3596,"end":3611}},{"label":"td","span":{"begin":3612,"end":3622}},{"label":"td","span":{"begin":3623,"end":3633}},{"label":"td","span":{"begin":3634,"end":3644}},{"label":"tr","span":{"begin":3645,"end":3687}},{"label":"td","span":{"begin":3645,"end":3656}},{"label":"td","span":{"begin":3657,"end":3666}},{"label":"td","span":{"begin":3667,"end":3676}},{"label":"td","span":{"begin":3677,"end":3687}},{"label":"tr","span":{"begin":3688,"end":3727}},{"label":"td","span":{"begin":3688,"end":3703}},{"label":"td","span":{"begin":3704,"end":3711}},{"label":"td","span":{"begin":3712,"end":3719}},{"label":"td","span":{"begin":3720,"end":3727}},{"label":"tr","span":{"begin":3728,"end":3756}},{"label":"td","span":{"begin":3728,"end":3750}},{"label":"td","span":{"begin":3751,"end":3752}},{"label":"td","span":{"begin":3753,"end":3754}},{"label":"td","span":{"begin":3755,"end":3756}},{"label":"tr","span":{"begin":3757,"end":3776}},{"label":"td","span":{"begin":3757,"end":3770}},{"label":"td","span":{"begin":3771,"end":3772}},{"label":"td","span":{"begin":3773,"end":3774}},{"label":"td","span":{"begin":3775,"end":3776}},{"label":"tr","span":{"begin":3777,"end":3807}},{"label":"td","span":{"begin":3777,"end":3783}},{"label":"td","span":{"begin":3784,"end":3791}},{"label":"td","span":{"begin":3792,"end":3799}},{"label":"td","span":{"begin":3800,"end":3807}},{"label":"tr","span":{"begin":3808,"end":3868}},{"label":"td","span":{"begin":3808,"end":3832}},{"label":"td","span":{"begin":3833,"end":3844}},{"label":"td","span":{"begin":3845,"end":3856}},{"label":"td","span":{"begin":3857,"end":3868}},{"label":"tr","span":{"begin":3869,"end":3917}},{"label":"td","span":{"begin":3869,"end":3884}},{"label":"td","span":{"begin":3885,"end":3895}},{"label":"td","span":{"begin":3896,"end":3906}},{"label":"td","span":{"begin":3907,"end":3917}},{"label":"tr","span":{"begin":3918,"end":3937}},{"label":"td","span":{"begin":3918,"end":3937}},{"label":"tr","span":{"begin":3938,"end":3985}},{"label":"td","span":{"begin":3938,"end":3953}},{"label":"td","span":{"begin":3954,"end":3964}},{"label":"td","span":{"begin":3965,"end":3974}},{"label":"td","span":{"begin":3975,"end":3985}},{"label":"tr","span":{"begin":3986,"end":4027}},{"label":"td","span":{"begin":3986,"end":3997}},{"label":"td","span":{"begin":3998,"end":4007}},{"label":"td","span":{"begin":4008,"end":4017}},{"label":"td","span":{"begin":4018,"end":4027}},{"label":"tr","span":{"begin":4028,"end":4067}},{"label":"td","span":{"begin":4028,"end":4043}},{"label":"td","span":{"begin":4044,"end":4051}},{"label":"td","span":{"begin":4052,"end":4059}},{"label":"td","span":{"begin":4060,"end":4067}},{"label":"tr","span":{"begin":4068,"end":4108}},{"label":"td","span":{"begin":4068,"end":4090}},{"label":"td","span":{"begin":4091,"end":4098}},{"label":"td","span":{"begin":4099,"end":4100}},{"label":"td","span":{"begin":4101,"end":4108}},{"label":"tr","span":{"begin":4109,"end":4128}},{"label":"td","span":{"begin":4109,"end":4122}},{"label":"td","span":{"begin":4123,"end":4124}},{"label":"td","span":{"begin":4125,"end":4126}},{"label":"td","span":{"begin":4127,"end":4128}},{"label":"table-wrap-foot","span":{"begin":4129,"end":4260}},{"label":"footnote","span":{"begin":4129,"end":4235}},{"label":"p","span":{"begin":4129,"end":4235}},{"label":"footnote","span":{"begin":4236,"end":4260}},{"label":"label","span":{"begin":4236,"end":4237}},{"label":"p","span":{"begin":4238,"end":4260}},{"label":"figure","span":{"begin":4700,"end":4756}},{"label":"label","span":{"begin":4700,"end":4709}},{"label":"caption","span":{"begin":4710,"end":4756}},{"label":"p","span":{"begin":4710,"end":4756}},{"label":"label","span":{"begin":4757,"end":4765}},{"label":"caption","span":{"begin":4766,"end":4840}},{"label":"p","span":{"begin":4766,"end":4840}},{"label":"table","span":{"begin":4841,"end":6063}},{"label":"tr","span":{"begin":4841,"end":4864}},{"label":"th","span":{"begin":4841,"end":4848}},{"label":"th","span":{"begin":4849,"end":4855}},{"label":"th","span":{"begin":4856,"end":4861}},{"label":"th","span":{"begin":4862,"end":4864}},{"label":"tr","span":{"begin":4865,"end":4872}},{"label":"td","span":{"begin":4865,"end":4872}},{"label":"tr","span":{"begin":4873,"end":4958}},{"label":"td","span":{"begin":4873,"end":4884}},{"label":"td","span":{"begin":4885,"end":4903}},{"label":"td","span":{"begin":4904,"end":4923}},{"label":"td","span":{"begin":4924,"end":4942}},{"label":"td","span":{"begin":4943,"end":4958}},{"label":"tr","span":{"begin":4959,"end":5048}},{"label":"td","span":{"begin":4959,"end":4976}},{"label":"td","span":{"begin":4977,"end":4994}},{"label":"td","span":{"begin":4995,"end":5012}},{"label":"td","span":{"begin":5013,"end":5031}},{"label":"td","span":{"begin":5032,"end":5048}},{"label":"tr","span":{"begin":5049,"end":5143}},{"label":"td","span":{"begin":5049,"end":5070}},{"label":"td","span":{"begin":5071,"end":5089}},{"label":"td","span":{"begin":5090,"end":5107}},{"label":"td","span":{"begin":5108,"end":5126}},{"label":"td","span":{"begin":5127,"end":5143}},{"label":"tr","span":{"begin":5144,"end":5225}},{"label":"td","span":{"begin":5144,"end":5153}},{"label":"td","span":{"begin":5154,"end":5171}},{"label":"td","span":{"begin":5172,"end":5189}},{"label":"td","span":{"begin":5190,"end":5208}},{"label":"td","span":{"begin":5209,"end":5225}},{"label":"tr","span":{"begin":5226,"end":5321}},{"label":"td","span":{"begin":5226,"end":5249}},{"label":"td","span":{"begin":5250,"end":5267}},{"label":"td","span":{"begin":5268,"end":5285}},{"label":"td","span":{"begin":5286,"end":5303}},{"label":"td","span":{"begin":5304,"end":5321}},{"label":"tr","span":{"begin":5322,"end":5361}},{"label":"td","span":{"begin":5322,"end":5335}},{"label":"td","span":{"begin":5336,"end":5338}},{"label":"td","span":{"begin":5339,"end":5356}},{"label":"td","span":{"begin":5357,"end":5358}},{"label":"td","span":{"begin":5359,"end":5361}},{"label":"tr","span":{"begin":5362,"end":5420}},{"label":"td","span":{"begin":5362,"end":5411}},{"label":"td","span":{"begin":5412,"end":5413}},{"label":"td","span":{"begin":5414,"end":5415}},{"label":"td","span":{"begin":5416,"end":5417}},{"label":"td","span":{"begin":5418,"end":5420}},{"label":"tr","span":{"begin":5421,"end":5498}},{"label":"td","span":{"begin":5421,"end":5470}},{"label":"td","span":{"begin":5471,"end":5473}},{"label":"td","span":{"begin":5474,"end":5493}},{"label":"td","span":{"begin":5494,"end":5495}},{"label":"td","span":{"begin":5496,"end":5498}},{"label":"tr","span":{"begin":5499,"end":5600}},{"label":"td","span":{"begin":5499,"end":5520}},{"label":"td","span":{"begin":5521,"end":5541}},{"label":"td","span":{"begin":5542,"end":5562}},{"label":"td","span":{"begin":5563,"end":5583}},{"label":"td","span":{"begin":5584,"end":5600}},{"label":"tr","span":{"begin":5601,"end":5631}},{"label":"td","span":{"begin":5601,"end":5607}},{"label":"td","span":{"begin":5608,"end":5615}},{"label":"td","span":{"begin":5616,"end":5623}},{"label":"td","span":{"begin":5624,"end":5631}},{"label":"tr","span":{"begin":5632,"end":5726}},{"label":"td","span":{"begin":5632,"end":5643}},{"label":"td","span":{"begin":5644,"end":5665}},{"label":"td","span":{"begin":5666,"end":5687}},{"label":"td","span":{"begin":5688,"end":5709}},{"label":"td","span":{"begin":5710,"end":5726}},{"label":"tr","span":{"begin":5727,"end":5819}},{"label":"td","span":{"begin":5727,"end":5744}},{"label":"td","span":{"begin":5745,"end":5763}},{"label":"td","span":{"begin":5764,"end":5783}},{"label":"td","span":{"begin":5784,"end":5802}},{"label":"td","span":{"begin":5803,"end":5819}},{"label":"tr","span":{"begin":5820,"end":5922}},{"label":"td","span":{"begin":5820,"end":5841}},{"label":"td","span":{"begin":5842,"end":5862}},{"label":"td","span":{"begin":5863,"end":5883}},{"label":"td","span":{"begin":5884,"end":5905}},{"label":"td","span":{"begin":5906,"end":5922}},{"label":"tr","span":{"begin":5923,"end":6004}},{"label":"td","span":{"begin":5923,"end":5931}},{"label":"td","span":{"begin":5932,"end":5950}},{"label":"td","span":{"begin":5951,"end":5968}},{"label":"td","span":{"begin":5969,"end":5987}},{"label":"td","span":{"begin":5988,"end":6004}},{"label":"tr","span":{"begin":6005,"end":6063}},{"label":"td","span":{"begin":6005,"end":6054}},{"label":"td","span":{"begin":6055,"end":6056}},{"label":"td","span":{"begin":6057,"end":6058}},{"label":"td","span":{"begin":6059,"end":6060}},{"label":"td","span":{"begin":6061,"end":6063}}],"tracks":[]}