PMC:539297 / 3793-4155
Annnotations
craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T584","span":{"begin":23,"end":43},"obj":"GO:0008150"},{"id":"T585","span":{"begin":76,"end":86},"obj":"UBERON:0002037"},{"id":"T586","span":{"begin":76,"end":95},"obj":"CL:1001611"},{"id":"T587","span":{"begin":122,"end":126},"obj":"PR:000005591"},{"id":"T588","span":{"begin":142,"end":146},"obj":"NCBITaxon:10088"},{"id":"T589","span":{"begin":159,"end":161},"obj":"UBERON:0002037"},{"id":"T590","span":{"begin":161,"end":165},"obj":"PR:000005591"},{"id":"T591","span":{"begin":241,"end":260},"obj":"GO:0043227"},{"id":"T592","span":{"begin":270,"end":278},"obj":"GO:0016020"},{"id":"T593","span":{"begin":270,"end":290},"obj":"GO:0055085"},{"id":"T594","span":{"begin":303,"end":316},"obj":"GO:0005739"},{"id":"T595","span":{"begin":350,"end":352},"obj":"UBERON:0002037"}],"text":"ommon JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8"}
craft-sa-dev
{"project":"craft-sa-dev","denotations":[{"id":"T1084","span":{"begin":11,"end":19},"obj":"NN"},{"id":"T1086","span":{"begin":6,"end":10},"obj":"NN"},{"id":"T1087","span":{"begin":20,"end":22},"obj":"IN"},{"id":"T1088","span":{"begin":23,"end":33},"obj":"JJ"},{"id":"T1089","span":{"begin":34,"end":43},"obj":"NNS"},{"id":"T1090","span":{"begin":43,"end":44},"obj":"."},{"id":"T1091","span":{"begin":44,"end":147},"obj":"sentence"},{"id":"T1092","span":{"begin":45,"end":54},"obj":"RB"},{"id":"T1093","span":{"begin":64,"end":75},"obj":"VBN"},{"id":"T1094","span":{"begin":54,"end":56},"obj":","},{"id":"T1095","span":{"begin":56,"end":58},"obj":"PRP"},{"id":"T1096","span":{"begin":59,"end":63},"obj":"VBP"},{"id":"T1097","span":{"begin":76,"end":86},"obj":"JJ"},{"id":"T1098","span":{"begin":111,"end":116},"obj":"NNS"},{"id":"T1099","span":{"begin":87,"end":95},"obj":"JJ"},{"id":"T1100","span":{"begin":96,"end":105},"obj":"NN"},{"id":"T1101","span":{"begin":106,"end":110},"obj":"NN"},{"id":"T1102","span":{"begin":117,"end":121},"obj":"IN"},{"id":"T1103","span":{"begin":122,"end":130},"obj":"NN"},{"id":"T1104","span":{"begin":142,"end":146},"obj":"NNS"},{"id":"T1105","span":{"begin":130,"end":131},"obj":"HYPH"},{"id":"T1106","span":{"begin":131,"end":132},"obj":"CD"},{"id":"T1107","span":{"begin":133,"end":138},"obj":"VB"},{"id":"T1108","span":{"begin":138,"end":139},"obj":"HYPH"},{"id":"T1109","span":{"begin":139,"end":141},"obj":"RP"},{"id":"T1110","span":{"begin":146,"end":147},"obj":"."},{"id":"T1112","span":{"begin":148,"end":158},"obj":"JJ"},{"id":"T1113","span":{"begin":172,"end":177},"obj":"NNS"},{"id":"T1114","span":{"begin":159,"end":169},"obj":"NN"},{"id":"T1115","span":{"begin":169,"end":170},"obj":"HYPH"},{"id":"T1116","span":{"begin":170,"end":171},"obj":"CD"},{"id":"T1117","span":{"begin":178,"end":185},"obj":"VBP"},{"id":"T1118","span":{"begin":186,"end":198},"obj":"JJ"},{"id":"T1119","span":{"begin":199,"end":208},"obj":"NNS"},{"id":"T1120","span":{"begin":209,"end":211},"obj":"IN"},{"id":"T1121","span":{"begin":212,"end":215},"obj":"DT"},{"id":"T1122","span":{"begin":216,"end":223},"obj":"NN"},{"id":"T1123","span":{"begin":223,"end":225},"obj":","},{"id":"T1124","span":{"begin":225,"end":228},"obj":"CC"},{"id":"T1125","span":{"begin":229,"end":230},"obj":"DT"},{"id":"T1126","span":{"begin":231,"end":237},"obj":"NN"},{"id":"T1127","span":{"begin":261,"end":269},"obj":"VBD"},{"id":"T1128","span":{"begin":238,"end":240},"obj":"IN"},{"id":"T1129","span":{"begin":241,"end":249},"obj":"NN"},{"id":"T1130","span":{"begin":250,"end":260},"obj":"NNS"},{"id":"T1131","span":{"begin":270,"end":278},"obj":"NN"},{"id":"T1132","span":{"begin":279,"end":290},"obj":"VBG"},{"id":"T1133","span":{"begin":291,"end":298},"obj":"NNS"},{"id":"T1134","span":{"begin":299,"end":302},"obj":"CC"},{"id":"T1135","span":{"begin":303,"end":316},"obj":"JJ"},{"id":"T1136","span":{"begin":317,"end":328},"obj":"NN"},{"id":"T1137","span":{"begin":329,"end":331},"obj":"IN"},{"id":"T1138","span":{"begin":332,"end":342},"obj":"JJ"},{"id":"T1139","span":{"begin":343,"end":349},"obj":"NN"},{"id":"T1141","span":{"begin":350,"end":360},"obj":"NN"},{"id":"T1142","span":{"begin":360,"end":361},"obj":"HYPH"},{"id":"T1143","span":{"begin":361,"end":362},"obj":"CD"}],"relations":[{"id":"R633","pred":"compound","subj":"T1086","obj":"T1084"},{"id":"R635","pred":"amod","subj":"T1088","obj":"T1089"},{"id":"R636","pred":"pobj","subj":"T1089","obj":"T1087"},{"id":"R638","pred":"advmod","subj":"T1092","obj":"T1093"},{"id":"R639","pred":"punct","subj":"T1094","obj":"T1093"},{"id":"R640","pred":"nsubj","subj":"T1095","obj":"T1093"},{"id":"R641","pred":"aux","subj":"T1096","obj":"T1093"},{"id":"R642","pred":"amod","subj":"T1097","obj":"T1098"},{"id":"R643","pred":"dobj","subj":"T1098","obj":"T1093"},{"id":"R644","pred":"amod","subj":"T1099","obj":"T1098"},{"id":"R645","pred":"compound","subj":"T1100","obj":"T1098"},{"id":"R646","pred":"compound","subj":"T1101","obj":"T1098"},{"id":"R647","pred":"prep","subj":"T1102","obj":"T1093"},{"id":"R648","pred":"nmod","subj":"T1103","obj":"T1104"},{"id":"R649","pred":"pobj","subj":"T1104","obj":"T1102"},{"id":"R650","pred":"punct","subj":"T1105","obj":"T1103"},{"id":"R651","pred":"nummod","subj":"T1106","obj":"T1103"},{"id":"R652","pred":"amod","subj":"T1107","obj":"T1104"},{"id":"R653","pred":"punct","subj":"T1108","obj":"T1107"},{"id":"R654","pred":"prt","subj":"T1109","obj":"T1107"},{"id":"R655","pred":"punct","subj":"T1110","obj":"T1093"},{"id":"R656","pred":"amod","subj":"T1112","obj":"T1113"},{"id":"R657","pred":"nsubj","subj":"T1113","obj":"T1117"},{"id":"R658","pred":"nmod","subj":"T1114","obj":"T1113"},{"id":"R659","pred":"punct","subj":"T1115","obj":"T1114"},{"id":"R660","pred":"nummod","subj":"T1116","obj":"T1114"},{"id":"R661","pred":"amod","subj":"T1118","obj":"T1119"},{"id":"R662","pred":"dobj","subj":"T1119","obj":"T1117"},{"id":"R663","pred":"prep","subj":"T1120","obj":"T1119"},{"id":"R664","pred":"det",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JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8"}
craft-ca-core-ex-dev
{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T678","span":{"begin":11,"end":19},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T679","span":{"begin":23,"end":33},"obj":"CHEBI_GO_EXT:biological_process_or_quality_or_role"},{"id":"T680","span":{"begin":23,"end":43},"obj":"GO:0008150"},{"id":"T681","span":{"begin":76,"end":86},"obj":"UBERON:0002037"},{"id":"T682","span":{"begin":76,"end":95},"obj":"CL:1001611"},{"id":"T683","span":{"begin":106,"end":110},"obj":"CL_GO_EXT:cell"},{"id":"T684","span":{"begin":122,"end":126},"obj":"PR_EXT:000005591"},{"id":"T685","span":{"begin":142,"end":146},"obj":"NCBITaxon:10088"},{"id":"T686","span":{"begin":159,"end":161},"obj":"UBERON:0002037"},{"id":"T687","span":{"begin":161,"end":165},"obj":"PR_EXT:000005591"},{"id":"T688","span":{"begin":172,"end":177},"obj":"CL_GO_EXT:cell"},{"id":"T689","span":{"begin":241,"end":260},"obj":"GO:0043227"},{"id":"T690","span":{"begin":270,"end":278},"obj":"GO:0016020"},{"id":"T691","span":{"begin":270,"end":290},"obj":"GO:0055085"},{"id":"T692","span":{"begin":303,"end":316},"obj":"GO:0005739"},{"id":"T693","span":{"begin":343,"end":349},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T694","span":{"begin":350,"end":352},"obj":"UBERON:0002037"}],"text":"ommon JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8"}