PMC:539297 / 3793-4155 JSONTXT

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    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T584","span":{"begin":23,"end":43},"obj":"GO:0008150"},{"id":"T585","span":{"begin":76,"end":86},"obj":"UBERON:0002037"},{"id":"T586","span":{"begin":76,"end":95},"obj":"CL:1001611"},{"id":"T587","span":{"begin":122,"end":126},"obj":"PR:000005591"},{"id":"T588","span":{"begin":142,"end":146},"obj":"NCBITaxon:10088"},{"id":"T589","span":{"begin":159,"end":161},"obj":"UBERON:0002037"},{"id":"T590","span":{"begin":161,"end":165},"obj":"PR:000005591"},{"id":"T591","span":{"begin":241,"end":260},"obj":"GO:0043227"},{"id":"T592","span":{"begin":270,"end":278},"obj":"GO:0016020"},{"id":"T593","span":{"begin":270,"end":290},"obj":"GO:0055085"},{"id":"T594","span":{"begin":303,"end":316},"obj":"GO:0005739"},{"id":"T595","span":{"begin":350,"end":352},"obj":"UBERON:0002037"}],"text":"ommon JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8"}

    craft-sa-dev

    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JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8"}

    craft-ca-core-ex-dev

    {"project":"craft-ca-core-ex-dev","denotations":[{"id":"T678","span":{"begin":11,"end":19},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T679","span":{"begin":23,"end":33},"obj":"CHEBI_GO_EXT:biological_process_or_quality_or_role"},{"id":"T680","span":{"begin":23,"end":43},"obj":"GO:0008150"},{"id":"T681","span":{"begin":76,"end":86},"obj":"UBERON:0002037"},{"id":"T682","span":{"begin":76,"end":95},"obj":"CL:1001611"},{"id":"T683","span":{"begin":106,"end":110},"obj":"CL_GO_EXT:cell"},{"id":"T684","span":{"begin":122,"end":126},"obj":"PR_EXT:000005591"},{"id":"T685","span":{"begin":142,"end":146},"obj":"NCBITaxon:10088"},{"id":"T686","span":{"begin":159,"end":161},"obj":"UBERON:0002037"},{"id":"T687","span":{"begin":161,"end":165},"obj":"PR_EXT:000005591"},{"id":"T688","span":{"begin":172,"end":177},"obj":"CL_GO_EXT:cell"},{"id":"T689","span":{"begin":241,"end":260},"obj":"GO:0043227"},{"id":"T690","span":{"begin":270,"end":278},"obj":"GO:0016020"},{"id":"T691","span":{"begin":270,"end":290},"obj":"GO:0055085"},{"id":"T692","span":{"begin":303,"end":316},"obj":"GO:0005739"},{"id":"T693","span":{"begin":343,"end":349},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T694","span":{"begin":350,"end":352},"obj":"UBERON:0002037"}],"text":"ommon JNCL mutation on biological processes. Therefore, we have established cerebellar neuronal precursor cell lines from Cln3Δex7/8 knock-in mice. Homozygous CbCln3Δex7/8 cells exhibit pathological hallmarks of the disease, and a survey of membrane organelles revealed membrane trafficking defects and mitochondrial dysfunction in homozygous mutant CbCln3Δex7/8"}