Id |
Subject |
Object |
Predicate |
Lexical cue |
T948 |
0-2 |
TO |
denotes |
To |
T949 |
3-10 |
VB |
denotes |
explore |
T950 |
66-75 |
VBD |
denotes |
generated |
T951 |
11-15 |
NN |
denotes |
JNCL |
T952 |
16-28 |
NN |
denotes |
pathogenesis |
T953 |
29-32 |
CC |
denotes |
and |
T954 |
33-41 |
NN |
denotes |
battenin |
T955 |
42-50 |
NN |
denotes |
function |
T956 |
50-52 |
, |
denotes |
, |
T957 |
52-54 |
PRP |
denotes |
we |
T958 |
55-65 |
RB |
denotes |
previously |
T959 |
76-77 |
DT |
denotes |
a |
T960 |
109-114 |
NN |
denotes |
model |
T961 |
78-89 |
RB |
denotes |
genetically |
T962 |
90-97 |
JJ |
denotes |
precise |
T963 |
98-102 |
NN |
denotes |
JNCL |
T964 |
103-108 |
NN |
denotes |
mouse |
T965 |
114-115 |
. |
denotes |
. |
T966 |
115-298 |
sentence |
denotes |
Cln3Δex7/8 knock-in mice harbor the ~1 kb common JNCL mutation and express a non-truncated mutant battenin isoform that is detectable with antibodies recognizing C-terminal epitopes. |
T967 |
116-124 |
NN |
denotes |
Cln3Δex7 |
T968 |
136-140 |
NNS |
denotes |
mice |
T969 |
124-125 |
HYPH |
denotes |
/ |
T970 |
125-126 |
CD |
denotes |
8 |
T971 |
127-132 |
VB |
denotes |
knock |
T972 |
132-133 |
HYPH |
denotes |
- |
T973 |
133-135 |
RP |
denotes |
in |
T974 |
141-147 |
VBP |
denotes |
harbor |
T975 |
148-151 |
DT |
denotes |
the |
T976 |
170-178 |
NN |
denotes |
mutation |
T977 |
152-153 |
SYM |
denotes |
~ |
T978 |
153-154 |
CD |
denotes |
1 |
T979 |
155-157 |
NN |
denotes |
kb |
T980 |
158-164 |
JJ |
denotes |
common |
T981 |
165-169 |
NN |
denotes |
JNCL |
T982 |
179-182 |
CC |
denotes |
and |
T983 |
183-190 |
VBP |
denotes |
express |
T984 |
191-192 |
DT |
denotes |
a |
T985 |
223-230 |
NN |
denotes |
isoform |
T986 |
193-206 |
JJ |
denotes |
non-truncated |
T987 |
207-213 |
NN |
denotes |
mutant |
T988 |
214-222 |
NN |
denotes |
battenin |
T989 |
231-235 |
WDT |
denotes |
that |
T990 |
236-238 |
VBZ |
denotes |
is |
T991 |
239-249 |
JJ |
denotes |
detectable |
T992 |
250-254 |
IN |
denotes |
with |
T993 |
255-265 |
NNS |
denotes |
antibodies |
T994 |
266-277 |
VBG |
denotes |
recognizing |
T995 |
278-279 |
NN |
denotes |
C |
T996 |
280-288 |
JJ |
denotes |
terminal |
T997 |
279-280 |
HYPH |
denotes |
- |
T998 |
289-297 |
NNS |
denotes |
epitopes |
T999 |
297-298 |
. |
denotes |
. |
T1000 |
298-509 |
sentence |
denotes |
Homozygous Cln3Δex7/8 knock-in mice exhibit a progressive JNCL-like disease, with perinatal onset of subunit c deposition in many cell types and later onset of neuronal dysfunction and behavioral deficits [12]. |
T1001 |
299-309 |
JJ |
denotes |
Homozygous |
T1002 |
330-334 |
NNS |
denotes |
mice |
T1003 |
310-318 |
NN |
denotes |
Cln3Δex7 |
T1004 |
318-319 |
HYPH |
denotes |
/ |
T1005 |
319-320 |
CD |
denotes |
8 |
T1006 |
321-326 |
VB |
denotes |
knock |
T1007 |
326-327 |
HYPH |
denotes |
- |
T1008 |
327-329 |
RP |
denotes |
in |
T1009 |
335-342 |
VBP |
denotes |
exhibit |
T1010 |
343-344 |
DT |
denotes |
a |
T1011 |
367-374 |
NN |
denotes |
disease |
T1012 |
345-356 |
JJ |
denotes |
progressive |
T1013 |
357-361 |
NN |
denotes |
JNCL |
T1014 |
362-366 |
JJ |
denotes |
like |
T1015 |
361-362 |
HYPH |
denotes |
- |
T1016 |
374-376 |
, |
denotes |
, |
T1017 |
376-380 |
IN |
denotes |
with |
T1018 |
381-390 |
JJ |
denotes |
perinatal |
T1019 |
391-396 |
NN |
denotes |
onset |
T1020 |
397-399 |
IN |
denotes |
of |
T1021 |
400-407 |
NN |
denotes |
subunit |
T1022 |
408-409 |
NN |
denotes |
c |
T1023 |
410-420 |
NN |
denotes |
deposition |
T1024 |
421-423 |
IN |
denotes |
in |
T1025 |
424-428 |
JJ |
denotes |
many |
T1026 |
434-439 |
NNS |
denotes |
types |
T1027 |
429-433 |
NN |
denotes |
cell |
T1028 |
440-443 |
CC |
denotes |
and |
T1029 |
444-449 |
JJ |
denotes |
later |
T1030 |
450-455 |
NN |
denotes |
onset |
T1031 |
456-458 |
IN |
denotes |
of |
T1032 |
459-467 |
JJ |
denotes |
neuronal |
T1033 |
468-479 |
NN |
denotes |
dysfunction |
T1034 |
480-483 |
CC |
denotes |
and |
T1035 |
484-494 |
JJ |
denotes |
behavioral |
T1061 |
620-626 |
NN |
denotes |
manner |
T1036 |
495-503 |
NNS |
denotes |
deficits |
T1037 |
504-505 |
-LRB- |
denotes |
[ |
T1038 |
505-507 |
CD |
denotes |
12 |
T1039 |
507-508 |
-RRB- |
denotes |
] |
T1040 |
508-509 |
. |
denotes |
. |
T1041 |
509-668 |
sentence |
denotes |
These findings suggest that the major JNCL defect leads to abnormal turnover of mitochondrial subunit c, in a manner that selectively compromises CNS neurons. |
T1042 |
510-515 |
DT |
denotes |
These |
T1043 |
516-524 |
NNS |
denotes |
findings |
T1044 |
525-532 |
VBP |
denotes |
suggest |
T1045 |
533-537 |
IN |
denotes |
that |
T1046 |
560-565 |
VBZ |
denotes |
leads |
T1047 |
538-541 |
DT |
denotes |
the |
T1048 |
553-559 |
NN |
denotes |
defect |
T1049 |
542-547 |
JJ |
denotes |
major |
T1050 |
548-552 |
NN |
denotes |
JNCL |
T1051 |
566-568 |
IN |
denotes |
to |
T1052 |
569-577 |
JJ |
denotes |
abnormal |
T1053 |
578-586 |
NN |
denotes |
turnover |
T1054 |
587-589 |
IN |
denotes |
of |
T1055 |
590-603 |
JJ |
denotes |
mitochondrial |
T1056 |
612-613 |
NN |
denotes |
c |
T1057 |
604-611 |
NN |
denotes |
subunit |
T1058 |
613-615 |
, |
denotes |
, |
T1059 |
615-617 |
IN |
denotes |
in |
T1060 |
618-619 |
DT |
denotes |
a |
T1062 |
627-631 |
WDT |
denotes |
that |
T1063 |
644-655 |
VBZ |
denotes |
compromises |
T1064 |
632-643 |
RB |
denotes |
selectively |
T1065 |
656-659 |
NN |
denotes |
CNS |
T1066 |
660-667 |
NNS |
denotes |
neurons |
T1067 |
667-668 |
. |
denotes |
. |
R504 |
T948 |
T949 |
aux |
To,explore |
R505 |
T949 |
T950 |
advcl |
explore,generated |
R506 |
T951 |
T952 |
compound |
JNCL,pathogenesis |
R507 |
T952 |
T949 |
dobj |
pathogenesis,explore |
R508 |
T953 |
T952 |
cc |
and,pathogenesis |
R509 |
T954 |
T955 |
compound |
battenin,function |
R510 |
T955 |
T952 |
conj |
function,pathogenesis |
R511 |
T956 |
T950 |
punct |
", ",generated |
R512 |
T957 |
T950 |
nsubj |
we,generated |
R513 |
T958 |
T950 |
advmod |
previously,generated |
R514 |
T959 |
T960 |
det |
a,model |
R516 |
T961 |
T962 |
advmod |
genetically,precise |
R517 |
T962 |
T960 |
amod |
precise,model |
R518 |
T963 |
T960 |
compound |
JNCL,model |
R519 |
T964 |
T960 |
compound |
mouse,model |
R520 |
T965 |
T950 |
punct |
.,generated |
R521 |
T967 |
T968 |
nmod |
Cln3Δex7,mice |
R522 |
T968 |
T974 |
nsubj |
mice,harbor |
R523 |
T969 |
T967 |
punct |
/,Cln3Δex7 |
R524 |
T970 |
T967 |
nummod |
8,Cln3Δex7 |
R525 |
T971 |
T968 |
amod |
knock,mice |
R526 |
T972 |
T971 |
punct |
-,knock |
R527 |
T973 |
T971 |
prt |
in,knock |
R528 |
T975 |
T976 |
det |
the,mutation |
R529 |
T976 |
T974 |
dobj |
mutation,harbor |
R530 |
T977 |
T978 |
punct |
~,1 |
R531 |
T978 |
T979 |
nummod |
1,kb |
R532 |
T979 |
T976 |
nmod |
kb,mutation |
R533 |
T980 |
T976 |
amod |
common,mutation |
R534 |
T981 |
T976 |
compound |
JNCL,mutation |
R535 |
T982 |
T974 |
cc |
and,harbor |
R536 |
T983 |
T974 |
conj |
express,harbor |
R537 |
T984 |
T985 |
det |
a,isoform |
R538 |
T985 |
T983 |
dobj |
isoform,express |
R539 |
T986 |
T985 |
amod |
non-truncated,isoform |
R540 |
T987 |
T988 |
compound |
mutant,battenin |
R541 |
T988 |
T985 |
compound |
battenin,isoform |
R542 |
T989 |
T990 |
dep |
that,is |
R543 |
T990 |
T985 |
relcl |
is,isoform |
R544 |
T991 |
T990 |
acomp |
detectable,is |
R545 |
T992 |
T990 |
prep |
with,is |
R546 |
T993 |
T992 |
pobj |
antibodies,with |
R547 |
T994 |
T993 |
acl |
recognizing,antibodies |
R548 |
T995 |
T996 |
npadvmod |
C,terminal |
R549 |
T996 |
T998 |
amod |
terminal,epitopes |
R550 |
T997 |
T996 |
punct |
-,terminal |
R551 |
T998 |
T994 |
dobj |
epitopes,recognizing |
R552 |
T999 |
T974 |
punct |
.,harbor |
R553 |
T1001 |
T1002 |
amod |
Homozygous,mice |
R554 |
T1002 |
T1009 |
nsubj |
mice,exhibit |
R555 |
T1003 |
T1002 |
nmod |
Cln3Δex7,mice |
R556 |
T1004 |
T1003 |
punct |
/,Cln3Δex7 |
R557 |
T1005 |
T1003 |
nummod |
8,Cln3Δex7 |
R558 |
T1006 |
T1002 |
amod |
knock,mice |
R559 |
T1007 |
T1006 |
punct |
-,knock |
R560 |
T1008 |
T1006 |
prt |
in,knock |
R561 |
T1010 |
T1011 |
det |
a,disease |
R563 |
T1012 |
T1011 |
amod |
progressive,disease |
R564 |
T1013 |
T1014 |
npadvmod |
JNCL,like |
R565 |
T1014 |
T1011 |
amod |
like,disease |
R566 |
T1015 |
T1014 |
punct |
-,like |
R567 |
T1016 |
T1011 |
punct |
", ",disease |
R568 |
T1017 |
T1011 |
prep |
with,disease |
R569 |
T1018 |
T1019 |
amod |
perinatal,onset |
R570 |
T1019 |
T1017 |
pobj |
onset,with |
R571 |
T1020 |
T1019 |
prep |
of,onset |
R572 |
T1021 |
T1022 |
compound |
subunit,c |
R573 |
T1022 |
T1023 |
compound |
c,deposition |
R574 |
T1023 |
T1020 |
pobj |
deposition,of |
R575 |
T1024 |
T1023 |
prep |
in,deposition |
R576 |
T1025 |
T1026 |
amod |
many,types |
R577 |
T1026 |
T1024 |
pobj |
types,in |
R578 |
T1027 |
T1026 |
compound |
cell,types |
R579 |
T1028 |
T1019 |
cc |
and,onset |
R580 |
T1029 |
T1030 |
amod |
later,onset |
R581 |
T1030 |
T1019 |
conj |
onset,onset |
R582 |
T1031 |
T1030 |
prep |
of,onset |
R583 |
T1032 |
T1033 |
amod |
neuronal,dysfunction |
R584 |
T1033 |
T1031 |
pobj |
dysfunction,of |
R585 |
T1034 |
T1033 |
cc |
and,dysfunction |
R586 |
T1035 |
T1036 |
amod |
behavioral,deficits |
R587 |
T1036 |
T1033 |
conj |
deficits,dysfunction |
R588 |
T1037 |
T1038 |
punct |
[,12 |
R589 |
T1038 |
T1009 |
parataxis |
12,exhibit |
R590 |
T1039 |
T1038 |
punct |
],12 |
R591 |
T1040 |
T1009 |
punct |
.,exhibit |
R592 |
T1042 |
T1043 |
det |
These,findings |
R593 |
T1043 |
T1044 |
nsubj |
findings,suggest |
R594 |
T1045 |
T1046 |
mark |
that,leads |
R596 |
T1047 |
T1048 |
det |
the,defect |
R597 |
T1048 |
T1046 |
nsubj |
defect,leads |
R598 |
T1049 |
T1048 |
amod |
major,defect |
R599 |
T1050 |
T1048 |
compound |
JNCL,defect |
R600 |
T1051 |
T1046 |
prep |
to,leads |
R601 |
T1052 |
T1053 |
amod |
abnormal,turnover |
R602 |
T1053 |
T1051 |
pobj |
turnover,to |
R603 |
T1054 |
T1053 |
prep |
of,turnover |
R604 |
T1055 |
T1056 |
amod |
mitochondrial,c |
R605 |
T1056 |
T1054 |
pobj |
c,of |
R606 |
T1057 |
T1056 |
compound |
subunit,c |
R607 |
T1058 |
T1046 |
punct |
", ",leads |
R608 |
T1059 |
T1046 |
prep |
in,leads |
R609 |
T1060 |
T1061 |
det |
a,manner |
R610 |
T1061 |
T1059 |
pobj |
manner,in |
R611 |
T1062 |
T1063 |
dep |
that,compromises |
R612 |
T1063 |
T1061 |
relcl |
compromises,manner |
R613 |
T1064 |
T1063 |
advmod |
selectively,compromises |
R614 |
T1065 |
T1066 |
compound |
CNS,neurons |
R615 |
T1066 |
T1063 |
dobj |
neurons,compromises |
R616 |
T1067 |
T1044 |
punct |
.,suggest |
R515 |
T960 |
T950 |
dobj |
model,generated |
R562 |
T1011 |
T1009 |
dobj |
disease,exhibit |
R595 |
T1046 |
T1044 |
ccomp |
leads,suggest |