Id |
Subject |
Object |
Predicate |
Lexical cue |
T3359 |
0-3 |
DT |
denotes |
The |
T3360 |
13-22 |
NN |
denotes |
transport |
T3361 |
4-12 |
JJ |
denotes |
abnormal |
T3362 |
53-62 |
VBD |
denotes |
suggested |
T3363 |
23-26 |
CC |
denotes |
and |
T3364 |
27-37 |
NN |
denotes |
processing |
T3365 |
38-40 |
IN |
denotes |
of |
T3366 |
41-50 |
NN |
denotes |
cathepsin |
T3367 |
51-52 |
NN |
denotes |
D |
T3368 |
144-152 |
VBD |
denotes |
surveyed |
T3369 |
63-71 |
NN |
denotes |
membrane |
T3370 |
72-83 |
NN |
denotes |
trafficking |
T3371 |
84-95 |
NNS |
denotes |
disruptions |
T3372 |
96-98 |
IN |
denotes |
in |
T3373 |
99-109 |
JJ |
denotes |
homozygous |
T3374 |
123-128 |
NNS |
denotes |
cells |
T3375 |
110-120 |
NN |
denotes |
CbCln3Δex7 |
T3376 |
120-121 |
HYPH |
denotes |
/ |
T3377 |
121-122 |
CD |
denotes |
8 |
T3378 |
128-129 |
: |
denotes |
; |
T3379 |
130-139 |
RB |
denotes |
therefore |
T3380 |
139-141 |
, |
denotes |
, |
T3381 |
141-143 |
PRP |
denotes |
we |
T3382 |
153-156 |
DT |
denotes |
the |
T3383 |
169-181 |
NN |
denotes |
distribution |
T3384 |
157-168 |
JJ |
denotes |
subcellular |
T3385 |
182-185 |
CC |
denotes |
and |
T3386 |
186-196 |
NN |
denotes |
morphology |
T3387 |
197-199 |
IN |
denotes |
of |
T3388 |
200-208 |
NN |
denotes |
membrane |
T3389 |
209-219 |
NNS |
denotes |
organelles |
T3390 |
219-220 |
. |
denotes |
. |
T3391 |
220-462 |
sentence |
denotes |
Components of the secretory pathway, including the ER, cis-Golgi, and trans-Golgi, did not appear altered from wild-type appearance when labeled with the respective markers, protein disulfide isomerase (PDI), GM130, and VVL (data not shown). |
T3392 |
221-231 |
NNS |
denotes |
Components |
T3393 |
312-318 |
VB |
denotes |
appear |
T3394 |
232-234 |
IN |
denotes |
of |
T3395 |
235-238 |
DT |
denotes |
the |
T3396 |
249-256 |
NN |
denotes |
pathway |
T3397 |
239-248 |
JJ |
denotes |
secretory |
T3398 |
256-258 |
, |
denotes |
, |
T3465 |
580-581 |
CD |
denotes |
8 |
T3399 |
258-267 |
VBG |
denotes |
including |
T3400 |
268-271 |
DT |
denotes |
the |
T3401 |
272-274 |
NN |
denotes |
ER |
T3402 |
274-276 |
, |
denotes |
, |
T3403 |
276-279 |
NN |
denotes |
cis |
T3404 |
280-285 |
NN |
denotes |
Golgi |
T3405 |
279-280 |
HYPH |
denotes |
- |
T3406 |
285-287 |
, |
denotes |
, |
T3407 |
287-290 |
CC |
denotes |
and |
T3408 |
291-296 |
NN |
denotes |
trans |
T3409 |
297-302 |
NN |
denotes |
Golgi |
T3410 |
296-297 |
HYPH |
denotes |
- |
T3411 |
302-304 |
, |
denotes |
, |
T3412 |
304-307 |
VBD |
denotes |
did |
T3413 |
308-311 |
RB |
denotes |
not |
T3414 |
319-326 |
JJ |
denotes |
altered |
T3415 |
327-331 |
IN |
denotes |
from |
T3416 |
332-336 |
JJ |
denotes |
wild |
T3417 |
337-341 |
NN |
denotes |
type |
T3418 |
336-337 |
HYPH |
denotes |
- |
T3419 |
342-352 |
NN |
denotes |
appearance |
T3420 |
353-357 |
WRB |
denotes |
when |
T3421 |
358-365 |
VBN |
denotes |
labeled |
T3422 |
366-370 |
IN |
denotes |
with |
T3423 |
371-374 |
DT |
denotes |
the |
T3424 |
386-393 |
NNS |
denotes |
markers |
T3425 |
375-385 |
JJ |
denotes |
respective |
T3426 |
393-395 |
, |
denotes |
, |
T3427 |
395-402 |
NN |
denotes |
protein |
T3428 |
413-422 |
NN |
denotes |
isomerase |
T3429 |
403-412 |
NN |
denotes |
disulfide |
T3430 |
423-424 |
-LRB- |
denotes |
( |
T3431 |
424-427 |
NN |
denotes |
PDI |
T3432 |
427-428 |
-RRB- |
denotes |
) |
T3433 |
428-430 |
, |
denotes |
, |
T3434 |
430-435 |
NN |
denotes |
GM130 |
T3435 |
435-437 |
, |
denotes |
, |
T3436 |
437-440 |
CC |
denotes |
and |
T3437 |
441-444 |
NN |
denotes |
VVL |
T3438 |
445-446 |
-LRB- |
denotes |
( |
T3439 |
455-460 |
VBN |
denotes |
shown |
T3440 |
446-450 |
NNS |
denotes |
data |
T3441 |
451-454 |
RB |
denotes |
not |
T3442 |
460-461 |
-RRB- |
denotes |
) |
T3443 |
461-462 |
. |
denotes |
. |
T3444 |
462-612 |
sentence |
denotes |
By contrast, the lysosomal markers, Lysotracker and Lamp 2 had significantly altered signal in homozygous CbCln3Δex7/8 cells, versus wild-type cells. |
T3445 |
463-465 |
IN |
denotes |
By |
T3446 |
522-525 |
VBD |
denotes |
had |
T3447 |
466-474 |
NN |
denotes |
contrast |
T3448 |
474-476 |
, |
denotes |
, |
T3449 |
476-479 |
DT |
denotes |
the |
T3450 |
490-497 |
NNS |
denotes |
markers |
T3451 |
480-489 |
JJ |
denotes |
lysosomal |
T3452 |
497-499 |
, |
denotes |
, |
T3453 |
499-510 |
NN |
denotes |
Lysotracker |
T3454 |
511-514 |
CC |
denotes |
and |
T3455 |
515-519 |
NN |
denotes |
Lamp |
T3456 |
520-521 |
CD |
denotes |
2 |
T3457 |
526-539 |
RB |
denotes |
significantly |
T3458 |
540-547 |
JJ |
denotes |
altered |
T3459 |
548-554 |
NN |
denotes |
signal |
T3460 |
555-557 |
IN |
denotes |
in |
T3461 |
558-568 |
JJ |
denotes |
homozygous |
T3462 |
582-587 |
NNS |
denotes |
cells |
T3463 |
569-579 |
NN |
denotes |
CbCln3Δex7 |
T3464 |
579-580 |
HYPH |
denotes |
/ |
T3466 |
587-589 |
, |
denotes |
, |
T3467 |
589-595 |
CC |
denotes |
versus |
T3468 |
596-600 |
JJ |
denotes |
wild |
T3469 |
601-605 |
NN |
denotes |
type |
T3470 |
600-601 |
HYPH |
denotes |
- |
T3471 |
606-611 |
NNS |
denotes |
cells |
T3472 |
611-612 |
. |
denotes |
. |
T3473 |
612-876 |
sentence |
denotes |
Wild-type cells exhibited brightly stained lysosomes that were large and clustered in the perinuclear region whereas homozygous CbCln3Δex7/8 lysosomes were lightly stained, smaller vesicles that were more diffusely scattered in the cytoplasm of the cell (Fig. 6). |
T3474 |
613-617 |
JJ |
denotes |
Wild |
T3475 |
618-622 |
NN |
denotes |
type |
T3476 |
617-618 |
HYPH |
denotes |
- |
T3477 |
623-628 |
NNS |
denotes |
cells |
T3478 |
629-638 |
VBD |
denotes |
exhibited |
T3479 |
639-647 |
RB |
denotes |
brightly |
T3480 |
648-655 |
VBN |
denotes |
stained |
T3481 |
656-665 |
NNS |
denotes |
lysosomes |
T3482 |
666-670 |
WDT |
denotes |
that |
T3483 |
671-675 |
VBD |
denotes |
were |
T3484 |
676-681 |
JJ |
denotes |
large |
T3485 |
682-685 |
CC |
denotes |
and |
T3486 |
686-695 |
JJ |
denotes |
clustered |
T3487 |
696-698 |
IN |
denotes |
in |
T3488 |
699-702 |
DT |
denotes |
the |
T3489 |
715-721 |
NN |
denotes |
region |
T3490 |
703-714 |
JJ |
denotes |
perinuclear |
T3491 |
722-729 |
IN |
denotes |
whereas |
T3492 |
764-768 |
VBD |
denotes |
were |
T3493 |
730-740 |
JJ |
denotes |
homozygous |
T3494 |
754-763 |
NNS |
denotes |
lysosomes |
T3495 |
741-751 |
NN |
denotes |
CbCln3Δex7 |
T3496 |
751-752 |
HYPH |
denotes |
/ |
T3497 |
752-753 |
CD |
denotes |
8 |
T3498 |
769-776 |
RB |
denotes |
lightly |
T3499 |
777-784 |
VBN |
denotes |
stained |
T3500 |
794-802 |
NNS |
denotes |
vesicles |
T3501 |
784-786 |
, |
denotes |
, |
T3502 |
786-793 |
JJR |
denotes |
smaller |
T3503 |
803-807 |
WDT |
denotes |
that |
T3504 |
828-837 |
VBN |
denotes |
scattered |
T3505 |
808-812 |
VBD |
denotes |
were |
T3506 |
813-817 |
RBR |
denotes |
more |
T3507 |
818-827 |
RB |
denotes |
diffusely |
T3508 |
838-840 |
IN |
denotes |
in |
T3509 |
841-844 |
DT |
denotes |
the |
T3510 |
845-854 |
NN |
denotes |
cytoplasm |
T3511 |
855-857 |
IN |
denotes |
of |
T3512 |
858-861 |
DT |
denotes |
the |
T3513 |
862-866 |
NN |
denotes |
cell |
T3514 |
867-868 |
-LRB- |
denotes |
( |
T3515 |
868-872 |
NN |
denotes |
Fig. |
T3516 |
873-874 |
CD |
denotes |
6 |
T3517 |
874-875 |
-RRB- |
denotes |
) |
T3518 |
875-876 |
. |
denotes |
. |
T3519 |
876-944 |
sentence |
denotes |
Lamp 1 distribution was also altered, as previously noted (Fig. 3). |
T3520 |
877-881 |
NN |
denotes |
Lamp |
T3521 |
884-896 |
NN |
denotes |
distribution |
T3522 |
882-883 |
CD |
denotes |
1 |
T3523 |
906-913 |
VBN |
denotes |
altered |
T3524 |
897-900 |
VBD |
denotes |
was |
T3525 |
901-905 |
RB |
denotes |
also |
T3526 |
913-915 |
, |
denotes |
, |
T3527 |
915-917 |
IN |
denotes |
as |
T3528 |
929-934 |
VBN |
denotes |
noted |
T3533 |
942-943 |
-RRB- |
denotes |
) |
T3534 |
943-944 |
. |
denotes |
. |
T3535 |
944-1212 |
sentence |
denotes |
However, Lamp 1 and Lamp 2 total protein levels were similar in wild-type and homozygous CbCln3Δex7/8 cells by immunoblot analysis, indicating the altered signal likely reflects dispersed lysosomes or altered localization and/or epitope availability (data not shown). |
T3536 |
945-952 |
RB |
denotes |
However |
T3537 |
993-997 |
VBD |
denotes |
were |
T3538 |
952-954 |
, |
denotes |
, |
T3539 |
954-958 |
NN |
denotes |
Lamp |
T3540 |
986-992 |
NNS |
denotes |
levels |
T3541 |
959-960 |
CD |
denotes |
1 |
T3542 |
961-964 |
CC |
denotes |
and |
T3543 |
965-969 |
NN |
denotes |
Lamp |
T3544 |
970-971 |
CD |
denotes |
2 |
T3545 |
972-977 |
JJ |
denotes |
total |
T3546 |
978-985 |
NN |
denotes |
protein |
T3547 |
998-1005 |
JJ |
denotes |
similar |
T3548 |
1006-1008 |
IN |
denotes |
in |
T3549 |
1009-1013 |
JJ |
denotes |
wild |
T3550 |
1014-1018 |
NN |
denotes |
type |
T3551 |
1013-1014 |
HYPH |
denotes |
- |
T3552 |
1047-1052 |
NNS |
denotes |
cells |
T3553 |
1019-1022 |
CC |
denotes |
and |
T3554 |
1023-1033 |
JJ |
denotes |
homozygous |
T3555 |
1034-1044 |
NN |
denotes |
CbCln3Δex7 |
T3556 |
1044-1045 |
HYPH |
denotes |
/ |
T3557 |
1045-1046 |
CD |
denotes |
8 |
T3558 |
1053-1055 |
IN |
denotes |
by |
T3559 |
1056-1066 |
NN |
denotes |
immunoblot |
T3560 |
1067-1075 |
NN |
denotes |
analysis |
T3561 |
1075-1077 |
, |
denotes |
, |
T3562 |
1077-1087 |
VBG |
denotes |
indicating |
T3563 |
1088-1091 |
DT |
denotes |
the |
T3564 |
1100-1106 |
NN |
denotes |
signal |
T3565 |
1092-1099 |
JJ |
denotes |
altered |
T3566 |
1114-1122 |
VBZ |
denotes |
reflects |
T3567 |
1107-1113 |
RB |
denotes |
likely |
T3568 |
1123-1132 |
JJ |
denotes |
dispersed |
T3569 |
1133-1142 |
NNS |
denotes |
lysosomes |
T3570 |
1143-1145 |
CC |
denotes |
or |
T3571 |
1146-1153 |
JJ |
denotes |
altered |
T3572 |
1154-1166 |
NN |
denotes |
localization |
T3573 |
1167-1170 |
CC |
denotes |
and |
T3574 |
1170-1171 |
HYPH |
denotes |
/ |
T3575 |
1171-1173 |
CC |
denotes |
or |
T3576 |
1174-1181 |
NN |
denotes |
epitope |
T3577 |
1182-1194 |
NN |
denotes |
availability |
T3578 |
1195-1196 |
-LRB- |
denotes |
( |
T3579 |
1205-1210 |
VBN |
denotes |
shown |
T3580 |
1196-1200 |
NNS |
denotes |
data |
T3581 |
1201-1204 |
RB |
denotes |
not |
T3582 |
1210-1211 |
-RRB- |
denotes |
) |
T3583 |
1211-1212 |
. |
denotes |
. |
T3584 |
1212-1364 |
sentence |
denotes |
It is noteworthy that Lysotracker dye, which selectively accumulates in acidic compartments, exhibited the most marked reduction in lysosomal labeling. |
T3585 |
1213-1215 |
PRP |
denotes |
It |
T3586 |
1216-1218 |
VBZ |
denotes |
is |
T3587 |
1219-1229 |
JJ |
denotes |
noteworthy |
T3588 |
1230-1234 |
IN |
denotes |
that |
T3589 |
1306-1315 |
VBD |
denotes |
exhibited |
T3590 |
1235-1246 |
NN |
denotes |
Lysotracker |
T3591 |
1247-1250 |
NN |
denotes |
dye |
T3592 |
1250-1252 |
, |
denotes |
, |
T3593 |
1252-1257 |
WDT |
denotes |
which |
T3594 |
1270-1281 |
VBZ |
denotes |
accumulates |
T3595 |
1258-1269 |
RB |
denotes |
selectively |
T3596 |
1282-1284 |
IN |
denotes |
in |
T3597 |
1285-1291 |
JJ |
denotes |
acidic |
T3598 |
1292-1304 |
NNS |
denotes |
compartments |
T3599 |
1304-1306 |
, |
denotes |
, |
T3600 |
1316-1319 |
DT |
denotes |
the |
T3601 |
1332-1341 |
NN |
denotes |
reduction |
T3602 |
1320-1324 |
RBS |
denotes |
most |
T3603 |
1325-1331 |
JJ |
denotes |
marked |
T3604 |
1342-1344 |
IN |
denotes |
in |
T3605 |
1345-1354 |
JJ |
denotes |
lysosomal |
T3606 |
1355-1363 |
NN |
denotes |
labeling |
T3607 |
1363-1364 |
. |
denotes |
. |
T3608 |
1364-1455 |
sentence |
denotes |
This observation may reflect altered lysosomal pH, an established finding in JNCL [10,15]. |
T3609 |
1365-1369 |
DT |
denotes |
This |
T3610 |
1370-1381 |
NN |
denotes |
observation |
T3611 |
1386-1393 |
VB |
denotes |
reflect |
T3612 |
1382-1385 |
MD |
denotes |
may |
T3613 |
1394-1401 |
JJ |
denotes |
altered |
T3614 |
1412-1414 |
NN |
denotes |
pH |
T3615 |
1402-1411 |
JJ |
denotes |
lysosomal |
T3616 |
1414-1416 |
, |
denotes |
, |
T3617 |
1416-1418 |
DT |
denotes |
an |
T3618 |
1431-1438 |
NN |
denotes |
finding |
T3619 |
1419-1430 |
JJ |
denotes |
established |
T3620 |
1439-1441 |
IN |
denotes |
in |
T3621 |
1442-1446 |
NN |
denotes |
JNCL |
T3622 |
1447-1448 |
-LRB- |
denotes |
[ |
T3623 |
1451-1453 |
CD |
denotes |
15 |
T3624 |
1448-1450 |
CD |
denotes |
10 |
T3625 |
1450-1451 |
, |
denotes |
, |
T3626 |
1453-1454 |
-RRB- |
denotes |
] |
T3627 |
1454-1455 |
. |
denotes |
. |
T3529 |
918-928 |
RB |
denotes |
previously |
T3530 |
935-936 |
-LRB- |
denotes |
( |
T3531 |
936-940 |
NN |
denotes |
Fig. |
T3532 |
941-942 |
CD |
denotes |
3 |
R1803 |
T3359 |
T3360 |
det |
The,transport |
R1804 |
T3360 |
T3362 |
nsubj |
transport,suggested |
R1805 |
T3361 |
T3360 |
amod |
abnormal,transport |
R1806 |
T3362 |
T3368 |
ccomp |
suggested,surveyed |
R1807 |
T3363 |
T3360 |
cc |
and,transport |
R1808 |
T3364 |
T3360 |
conj |
processing,transport |
R1809 |
T3365 |
T3360 |
prep |
of,transport |
R1810 |
T3366 |
T3367 |
compound |
cathepsin,D |
R1811 |
T3367 |
T3365 |
pobj |
D,of |
R1812 |
T3369 |
T3370 |
compound |
membrane,trafficking |
R1813 |
T3370 |
T3371 |
compound |
trafficking,disruptions |
R1814 |
T3371 |
T3362 |
dobj |
disruptions,suggested |
R1815 |
T3372 |
T3362 |
prep |
in,suggested |
R1816 |
T3373 |
T3374 |
amod |
homozygous,cells |
R1817 |
T3374 |
T3372 |
pobj |
cells,in |
R1818 |
T3375 |
T3374 |
nmod |
CbCln3Δex7,cells |
R1819 |
T3376 |
T3375 |
punct |
/,CbCln3Δex7 |
R1820 |
T3377 |
T3375 |
nummod |
8,CbCln3Δex7 |
R1821 |
T3378 |
T3368 |
punct |
;,surveyed |
R1822 |
T3379 |
T3368 |
advmod |
therefore,surveyed |
R1823 |
T3380 |
T3368 |
punct |
", ",surveyed |
R1824 |
T3381 |
T3368 |
nsubj |
we,surveyed |
R1825 |
T3382 |
T3383 |
det |
the,distribution |
R1826 |
T3383 |
T3368 |
dobj |
distribution,surveyed |
R1827 |
T3384 |
T3383 |
amod |
subcellular,distribution |
R1828 |
T3385 |
T3383 |
cc |
and,distribution |
R1829 |
T3386 |
T3383 |
conj |
morphology,distribution |
R1830 |
T3387 |
T3383 |
prep |
of,distribution |
R1831 |
T3388 |
T3389 |
compound |
membrane,organelles |
R1832 |
T3389 |
T3387 |
pobj |
organelles,of |
R1833 |
T3390 |
T3368 |
punct |
.,surveyed |
R1834 |
T3392 |
T3393 |
nsubj |
Components,appear |
R1835 |
T3394 |
T3392 |
prep |
of,Components |
R1836 |
T3395 |
T3396 |
det |
the,pathway |
R1837 |
T3396 |
T3394 |
pobj |
pathway,of |
R1838 |
T3397 |
T3396 |
amod |
secretory,pathway |
R1839 |
T3398 |
T3392 |
punct |
", ",Components |
R1840 |
T3399 |
T3392 |
prep |
including,Components |
R1841 |
T3400 |
T3401 |
det |
the,ER |
R1842 |
T3401 |
T3399 |
pobj |
ER,including |
R1843 |
T3402 |
T3401 |
punct |
", ",ER |
R1844 |
T3403 |
T3404 |
compound |
cis,Golgi |
R1845 |
T3404 |
T3401 |
conj |
Golgi,ER |
R1846 |
T3405 |
T3404 |
punct |
-,Golgi |
R1847 |
T3406 |
T3404 |
punct |
", ",Golgi |
R1848 |
T3407 |
T3404 |
cc |
and,Golgi |
R1849 |
T3408 |
T3409 |
compound |
trans,Golgi |
R1850 |
T3409 |
T3404 |
conj |
Golgi,Golgi |
R1851 |
T3410 |
T3409 |
punct |
-,Golgi |
R1852 |
T3411 |
T3393 |
punct |
", ",appear |
R1853 |
T3412 |
T3393 |
aux |
did,appear |
R1854 |
T3413 |
T3393 |
neg |
not,appear |
R1855 |
T3414 |
T3393 |
oprd |
altered,appear |
R1856 |
T3415 |
T3414 |
prep |
from,altered |
R1857 |
T3416 |
T3417 |
amod |
wild,type |
R1858 |
T3417 |
T3419 |
compound |
type,appearance |
R1859 |
T3418 |
T3417 |
punct |
-,type |
R1860 |
T3419 |
T3415 |
pobj |
appearance,from |
R1861 |
T3420 |
T3421 |
advmod |
when,labeled |
R1862 |
T3421 |
T3393 |
advcl |
labeled,appear |
R1863 |
T3422 |
T3421 |
prep |
with,labeled |
R1864 |
T3423 |
T3424 |
det |
the,markers |
R1865 |
T3424 |
T3422 |
pobj |
markers,with |
R1866 |
T3425 |
T3424 |
amod |
respective,markers |
R1867 |
T3426 |
T3424 |
punct |
", ",markers |
R1868 |
T3427 |
T3428 |
compound |
protein,isomerase |
R1869 |
T3428 |
T3424 |
appos |
isomerase,markers |
R1870 |
T3429 |
T3428 |
compound |
disulfide,isomerase |
R1871 |
T3430 |
T3428 |
punct |
(,isomerase |
R1872 |
T3431 |
T3428 |
appos |
PDI,isomerase |
R1873 |
T3432 |
T3428 |
punct |
),isomerase |
R1874 |
T3433 |
T3428 |
punct |
", ",isomerase |
R1875 |
T3434 |
T3428 |
conj |
GM130,isomerase |
R1876 |
T3435 |
T3434 |
punct |
", ",GM130 |
R1877 |
T3436 |
T3434 |
cc |
and,GM130 |
R1878 |
T3437 |
T3434 |
conj |
VVL,GM130 |
R1879 |
T3438 |
T3439 |
punct |
(,shown |
R1880 |
T3439 |
T3393 |
parataxis |
shown,appear |
R1881 |
T3440 |
T3439 |
nsubj |
data,shown |
R1882 |
T3441 |
T3439 |
neg |
not,shown |
R1883 |
T3442 |
T3439 |
punct |
),shown |
R1884 |
T3443 |
T3393 |
punct |
.,appear |
R1885 |
T3445 |
T3446 |
prep |
By,had |
R1886 |
T3447 |
T3445 |
pobj |
contrast,By |
R1887 |
T3448 |
T3446 |
punct |
", ",had |
R1888 |
T3449 |
T3450 |
det |
the,markers |
R1889 |
T3450 |
T3446 |
nsubj |
markers,had |
R1890 |
T3451 |
T3450 |
amod |
lysosomal,markers |
R1891 |
T3452 |
T3450 |
punct |
", ",markers |
R1892 |
T3453 |
T3450 |
appos |
Lysotracker,markers |
R1893 |
T3454 |
T3453 |
cc |
and,Lysotracker |
R1894 |
T3455 |
T3453 |
conj |
Lamp,Lysotracker |
R1895 |
T3456 |
T3455 |
nummod |
2,Lamp |
R1896 |
T3457 |
T3458 |
advmod |
significantly,altered |
R1897 |
T3458 |
T3459 |
amod |
altered,signal |
R1898 |
T3459 |
T3446 |
dobj |
signal,had |
R1899 |
T3460 |
T3446 |
prep |
in,had |
R1900 |
T3461 |
T3462 |
amod |
homozygous,cells |
R1901 |
T3462 |
T3460 |
pobj |
cells,in |
R1902 |
T3463 |
T3462 |
nmod |
CbCln3Δex7,cells |
R1903 |
T3464 |
T3463 |
punct |
/,CbCln3Δex7 |
R1904 |
T3465 |
T3463 |
nummod |
8,CbCln3Δex7 |
R1905 |
T3466 |
T3462 |
punct |
", ",cells |
R1906 |
T3467 |
T3462 |
cc |
versus,cells |
R1907 |
T3468 |
T3469 |
amod |
wild,type |
R1908 |
T3469 |
T3471 |
compound |
type,cells |
R1909 |
T3470 |
T3469 |
punct |
-,type |
R1910 |
T3471 |
T3462 |
conj |
cells,cells |
R1911 |
T3472 |
T3446 |
punct |
.,had |
R1912 |
T3474 |
T3475 |
amod |
Wild,type |
R1913 |
T3475 |
T3477 |
compound |
type,cells |
R1914 |
T3476 |
T3475 |
punct |
-,type |
R1915 |
T3477 |
T3478 |
nsubj |
cells,exhibited |
R1916 |
T3479 |
T3480 |
advmod |
brightly,stained |
R1917 |
T3480 |
T3481 |
amod |
stained,lysosomes |
R1918 |
T3481 |
T3478 |
dobj |
lysosomes,exhibited |
R1919 |
T3482 |
T3483 |
dep |
that,were |
R1920 |
T3483 |
T3481 |
relcl |
were,lysosomes |
R1921 |
T3484 |
T3483 |
acomp |
large,were |
R1922 |
T3485 |
T3484 |
cc |
and,large |
R1923 |
T3486 |
T3484 |
conj |
clustered,large |
R1924 |
T3487 |
T3483 |
prep |
in,were |
R1925 |
T3488 |
T3489 |
det |
the,region |
R1926 |
T3489 |
T3487 |
pobj |
region,in |
R1927 |
T3490 |
T3489 |
amod |
perinuclear,region |
R1928 |
T3491 |
T3492 |
mark |
whereas,were |
R1929 |
T3492 |
T3483 |
advcl |
were,were |
R1930 |
T3493 |
T3494 |
amod |
homozygous,lysosomes |
R1931 |
T3494 |
T3492 |
nsubj |
lysosomes,were |
R1932 |
T3495 |
T3494 |
nmod |
CbCln3Δex7,lysosomes |
R1933 |
T3496 |
T3495 |
punct |
/,CbCln3Δex7 |
R1934 |
T3497 |
T3495 |
nummod |
8,CbCln3Δex7 |
R1935 |
T3498 |
T3499 |
advmod |
lightly,stained |
R1936 |
T3499 |
T3500 |
amod |
stained,vesicles |
R1937 |
T3500 |
T3492 |
attr |
vesicles,were |
R1938 |
T3501 |
T3500 |
punct |
", ",vesicles |
R1939 |
T3502 |
T3500 |
amod |
smaller,vesicles |
R1940 |
T3503 |
T3504 |
dep |
that,scattered |
R1941 |
T3504 |
T3500 |
relcl |
scattered,vesicles |
R1942 |
T3505 |
T3504 |
auxpass |
were,scattered |
R1943 |
T3506 |
T3507 |
advmod |
more,diffusely |
R1944 |
T3507 |
T3504 |
advmod |
diffusely,scattered |
R1945 |
T3508 |
T3504 |
prep |
in,scattered |
R1946 |
T3509 |
T3510 |
det |
the,cytoplasm |
R1947 |
T3510 |
T3508 |
pobj |
cytoplasm,in |
R1948 |
T3511 |
T3510 |
prep |
of,cytoplasm |
R1949 |
T3512 |
T3513 |
det |
the,cell |
R1950 |
T3513 |
T3511 |
pobj |
cell,of |
R1951 |
T3514 |
T3515 |
punct |
(,Fig. |
R1952 |
T3515 |
T3478 |
parataxis |
Fig.,exhibited |
R1953 |
T3516 |
T3515 |
nummod |
6,Fig. |
R1954 |
T3517 |
T3515 |
punct |
),Fig. |
R1955 |
T3518 |
T3478 |
punct |
.,exhibited |
R1956 |
T3520 |
T3521 |
nmod |
Lamp,distribution |
R1957 |
T3521 |
T3523 |
nsubjpass |
distribution,altered |
R1958 |
T3522 |
T3520 |
nummod |
1,Lamp |
R1959 |
T3524 |
T3523 |
auxpass |
was,altered |
R1960 |
T3525 |
T3523 |
advmod |
also,altered |
R1961 |
T3526 |
T3523 |
punct |
", ",altered |
R1962 |
T3527 |
T3528 |
mark |
as,noted |
R1963 |
T3528 |
T3523 |
advcl |
noted,altered |
R1964 |
T3529 |
T3528 |
advmod |
previously,noted |
R1965 |
T3530 |
T3531 |
punct |
(,Fig. |
R1966 |
T3531 |
T3523 |
parataxis |
Fig.,altered |
R1967 |
T3532 |
T3531 |
nummod |
3,Fig. |
R1968 |
T3533 |
T3531 |
punct |
),Fig. |
R1969 |
T3534 |
T3523 |
punct |
.,altered |
R1970 |
T3536 |
T3537 |
advmod |
However,were |
R1971 |
T3538 |
T3537 |
punct |
", ",were |
R1972 |
T3539 |
T3540 |
nmod |
Lamp,levels |
R1973 |
T3540 |
T3537 |
nsubj |
levels,were |
R1974 |
T3541 |
T3539 |
nummod |
1,Lamp |
R1975 |
T3542 |
T3539 |
cc |
and,Lamp |
R1976 |
T3543 |
T3539 |
conj |
Lamp,Lamp |
R1977 |
T3544 |
T3543 |
nummod |
2,Lamp |
R1978 |
T3545 |
T3546 |
amod |
total,protein |
R1979 |
T3546 |
T3540 |
compound |
protein,levels |
R1980 |
T3547 |
T3537 |
acomp |
similar,were |
R1981 |
T3548 |
T3537 |
prep |
in,were |
R1982 |
T3549 |
T3550 |
amod |
wild,type |
R1984 |
T3551 |
T3550 |
punct |
-,type |
R1992 |
T3559 |
T3560 |
compound |
immunoblot,analysis |
R1993 |
T3560 |
T3558 |
pobj |
analysis,by |
R1994 |
T3561 |
T3537 |
punct |
", ",were |
R1995 |
T3562 |
T3537 |
advcl |
indicating,were |
R1996 |
T3563 |
T3564 |
det |
the,signal |
R1997 |
T3564 |
T3566 |
nsubj |
signal,reflects |
R1998 |
T3565 |
T3564 |
amod |
altered,signal |
R1999 |
T3566 |
T3562 |
advcl |
reflects,indicating |
R2000 |
T3567 |
T3566 |
advmod |
likely,reflects |
R2001 |
T3568 |
T3569 |
amod |
dispersed,lysosomes |
R2002 |
T3569 |
T3566 |
dobj |
lysosomes,reflects |
R2003 |
T3570 |
T3569 |
cc |
or,lysosomes |
R2004 |
T3571 |
T3572 |
amod |
altered,localization |
R2005 |
T3572 |
T3569 |
conj |
localization,lysosomes |
R2006 |
T3573 |
T3572 |
cc |
and,localization |
R2007 |
T3574 |
T3572 |
punct |
/,localization |
R2008 |
T3575 |
T3572 |
cc |
or,localization |
R2009 |
T3576 |
T3577 |
compound |
epitope,availability |
R2010 |
T3577 |
T3572 |
conj |
availability,localization |
R2011 |
T3578 |
T3579 |
punct |
(,shown |
R2012 |
T3579 |
T3562 |
parataxis |
shown,indicating |
R2013 |
T3580 |
T3579 |
nsubj |
data,shown |
R2014 |
T3581 |
T3579 |
neg |
not,shown |
R2015 |
T3582 |
T3579 |
punct |
),shown |
R2016 |
T3583 |
T3537 |
punct |
.,were |
R2017 |
T3585 |
T3586 |
nsubj |
It,is |
R2018 |
T3587 |
T3586 |
acomp |
noteworthy,is |
R2019 |
T3588 |
T3589 |
mark |
that,exhibited |
R2020 |
T3589 |
T3586 |
ccomp |
exhibited,is |
R2021 |
T3590 |
T3591 |
compound |
Lysotracker,dye |
R2022 |
T3591 |
T3589 |
nsubj |
dye,exhibited |
R2023 |
T3592 |
T3591 |
punct |
", ",dye |
R2024 |
T3593 |
T3594 |
dep |
which,accumulates |
R2025 |
T3594 |
T3591 |
relcl |
accumulates,dye |
R2026 |
T3595 |
T3594 |
advmod |
selectively,accumulates |
R2027 |
T3596 |
T3594 |
prep |
in,accumulates |
R2028 |
T3597 |
T3598 |
amod |
acidic,compartments |
R2029 |
T3598 |
T3596 |
pobj |
compartments,in |
R2030 |
T3599 |
T3589 |
punct |
", ",exhibited |
R2031 |
T3600 |
T3601 |
det |
the,reduction |
R2032 |
T3601 |
T3589 |
dobj |
reduction,exhibited |
R2033 |
T3602 |
T3603 |
advmod |
most,marked |
R2034 |
T3603 |
T3601 |
amod |
marked,reduction |
R2035 |
T3604 |
T3601 |
prep |
in,reduction |
R2036 |
T3605 |
T3606 |
amod |
lysosomal,labeling |
R2037 |
T3606 |
T3604 |
pobj |
labeling,in |
R2038 |
T3607 |
T3586 |
punct |
.,is |
R2039 |
T3609 |
T3610 |
det |
This,observation |
R2040 |
T3610 |
T3611 |
nsubj |
observation,reflect |
R2041 |
T3612 |
T3611 |
aux |
may,reflect |
R2042 |
T3613 |
T3614 |
amod |
altered,pH |
R2043 |
T3614 |
T3611 |
dobj |
pH,reflect |
R2044 |
T3615 |
T3614 |
amod |
lysosomal,pH |
R2045 |
T3616 |
T3614 |
punct |
", ",pH |
R2046 |
T3617 |
T3618 |
det |
an,finding |
R2047 |
T3618 |
T3614 |
appos |
finding,pH |
R2048 |
T3619 |
T3618 |
amod |
established,finding |
R2049 |
T3620 |
T3618 |
prep |
in,finding |
R2050 |
T3621 |
T3620 |
pobj |
JNCL,in |
R2051 |
T3622 |
T3623 |
punct |
[,15 |
R2052 |
T3623 |
T3611 |
parataxis |
15,reflect |
R2053 |
T3624 |
T3623 |
nummod |
10,15 |
R2054 |
T3625 |
T3623 |
punct |
",",15 |
R2055 |
T3626 |
T3623 |
punct |
],15 |
R2056 |
T3627 |
T3611 |
punct |
.,reflect |
R1983 |
T3550 |
T3552 |
nmod |
type,cells |
R1985 |
T3552 |
T3548 |
pobj |
cells,in |
R1986 |
T3553 |
T3550 |
cc |
and,type |
R1987 |
T3554 |
T3550 |
conj |
homozygous,type |
R1988 |
T3555 |
T3552 |
nmod |
CbCln3Δex7,cells |
R1989 |
T3556 |
T3555 |
punct |
/,CbCln3Δex7 |
R1990 |
T3557 |
T3555 |
nummod |
8,CbCln3Δex7 |
R1991 |
T3558 |
T3537 |
prep |
by,were |