
PMC:539297 / 14749-15419
Annnotations
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2410 | 4-5 | PR:000006025 | denotes | i |
T2411 | 32-37 | PR:000006025 | denotes | sin D |
T2412 | 155-164 | PR:000022190 | denotes | subunit c |
T2413 | 180-191 | CHEBI:76219 | denotes | fluorogenic |
T2414 | 208-219 | PR:000006025 | denotes | cathepsin D |
T2415 | 300-302 | UBERON:0002037 | denotes | Cb |
T2416 | 302-306 | PR:000005591 | denotes | Cln3 |
T2417 | 509-520 | PR:000006025 | denotes | cathepsin D |
T2418 | 574-576 | UBERON:0002037 | denotes | Cb |
T2419 | 576-580 | PR:000005591 | denotes | Cln3 |
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2889 | 111-120 | JJ | denotes | enzymatic |
T2890 | 139-142 | IN | denotes | for |
T2891 | 143-154 | JJ | denotes | inefficient |
T2892 | 165-173 | NN | denotes | turnover |
T2893 | 155-162 | NN | denotes | subunit |
T2894 | 163-164 | NN | denotes | c |
T2895 | 173-174 | . | denotes | . |
T2896 | 174-502 | sentence | denotes | In a fluorogenic in vitro assay, cathepsin D activity in total cellular extracts was not significantly altered in homozygous CbCln3Δex7/8 cells (376 ± 89 RFU/μg total protein), versus wild-type cells (324 ± 58 RFU/μg total protein), although a consistent trend towards increased enzymatic activity in mutant cells was observed. |
T2897 | 175-177 | IN | denotes | In |
T2898 | 278-285 | VBN | denotes | altered |
T2899 | 178-179 | DT | denotes | a |
T2900 | 201-206 | NN | denotes | assay |
T2901 | 180-191 | JJ | denotes | fluorogenic |
T2902 | 192-194 | FW | denotes | in |
T2903 | 195-200 | FW | denotes | vitro |
T2904 | 206-208 | , | denotes | , |
T2905 | 208-217 | NN | denotes | cathepsin |
T2906 | 218-219 | NN | denotes | D |
T2907 | 220-228 | NN | denotes | activity |
T2908 | 229-231 | IN | denotes | in |
T2909 | 232-237 | JJ | denotes | total |
T2910 | 247-255 | NNS | denotes | extracts |
T2911 | 238-246 | JJ | denotes | cellular |
T2912 | 256-259 | VBD | denotes | was |
T2913 | 260-263 | RB | denotes | not |
T2914 | 264-277 | RB | denotes | significantly |
T2915 | 286-288 | IN | denotes | in |
T2916 | 289-299 | JJ | denotes | homozygous |
T2917 | 313-318 | NNS | denotes | cells |
T2918 | 300-310 | NN | denotes | CbCln3Δex7 |
T2919 | 310-311 | HYPH | denotes | / |
T2920 | 311-312 | CD | denotes | 8 |
T2921 | 319-320 | -LRB- | denotes | ( |
T2922 | 329-332 | NN | denotes | RFU |
T2923 | 320-323 | CD | denotes | 376 |
T2924 | 326-328 | CD | denotes | 89 |
T2925 | 324-325 | SYM | denotes | ± |
T2926 | 332-333 | SYM | denotes | / |
T2927 | 342-349 | NN | denotes | protein |
T2928 | 333-335 | NN | denotes | μg |
T2929 | 336-341 | JJ | denotes | total |
T2930 | 349-350 | -RRB- | denotes | ) |
T2931 | 350-352 | , | denotes | , |
T2932 | 352-358 | CC | denotes | versus |
T2933 | 359-363 | JJ | denotes | wild |
T2934 | 364-368 | NN | denotes | type |
T2935 | 363-364 | HYPH | denotes | - |
T2936 | 369-374 | NNS | denotes | cells |
T2937 | 375-376 | -LRB- | denotes | ( |
T2938 | 385-388 | NN | denotes | RFU |
T2939 | 376-379 | CD | denotes | 324 |
T2940 | 382-384 | CD | denotes | 58 |
T2941 | 380-381 | IN | denotes | ± |
T2942 | 388-389 | SYM | denotes | / |
T2943 | 398-405 | NN | denotes | protein |
T2944 | 389-391 | NN | denotes | μg |
T2945 | 392-397 | JJ | denotes | total |
T2946 | 405-406 | -RRB- | denotes | ) |
T2947 | 406-408 | , | denotes | , |
T2948 | 408-416 | IN | denotes | although |
T2949 | 493-501 | VBN | denotes | observed |
T2950 | 417-418 | DT | denotes | a |
T2951 | 430-435 | NN | denotes | trend |
T2952 | 419-429 | JJ | denotes | consistent |
T2953 | 436-443 | IN | denotes | towards |
T2954 | 444-453 | VBN | denotes | increased |
T2955 | 464-472 | NN | denotes | activity |
T2956 | 454-463 | JJ | denotes | enzymatic |
T2957 | 473-475 | IN | denotes | in |
T2958 | 476-482 | NN | denotes | mutant |
T2959 | 483-488 | NNS | denotes | cells |
T2960 | 489-492 | VBD | denotes | was |
T2961 | 501-502 | . | denotes | . |
T2962 | 502-670 | sentence | denotes | Thus, cathepsin D transport and processing are disrupted in homozygous CbCln3Δex7/8 cells in a manner such that enzymatic activity appears to be relatively unaffected. |
T2963 | 503-507 | RB | denotes | Thus |
T2964 | 550-559 | VBN | denotes | disrupted |
T2965 | 507-509 | , | denotes | , |
T2966 | 509-518 | NN | denotes | cathepsin |
T2967 | 519-520 | NN | denotes | D |
T2968 | 521-530 | NN | denotes | transport |
T2969 | 531-534 | CC | denotes | and |
T2970 | 535-545 | NN | denotes | processing |
T2971 | 546-549 | VBP | denotes | are |
T2972 | 560-562 | IN | denotes | in |
T2973 | 563-573 | JJ | denotes | homozygous |
T2974 | 587-592 | NNS | denotes | cells |
T2975 | 574-584 | NN | denotes | CbCln3Δex7 |
T2976 | 584-585 | HYPH | denotes | / |
T2977 | 585-586 | CD | denotes | 8 |
T2978 | 593-595 | IN | denotes | in |
T2979 | 596-597 | DT | denotes | a |
T2980 | 598-604 | NN | denotes | manner |
T2981 | 605-609 | JJ | denotes | such |
T2982 | 610-614 | IN | denotes | that |
T2983 | 634-641 | VBZ | denotes | appears |
T2984 | 615-624 | JJ | denotes | enzymatic |
T2985 | 625-633 | NN | denotes | activity |
T2986 | 642-644 | TO | denotes | to |
T2987 | 645-647 | VB | denotes | be |
T2988 | 648-658 | RB | denotes | relatively |
T2989 | 659-669 | JJ | denotes | unaffected |
T2990 | 669-670 | . | denotes | . |
T2849 | 0-19 | sentence | denotes | The impact of the a |
T2850 | 0-3 | DT | denotes | The |
T2851 | 4-5 | NN | denotes | i |
T2852 | 5-6 | JJ | denotes | m |
T2853 | 6-7 | NN | denotes | p |
T2854 | 7-8 | CC | denotes | a |
T2855 | 8-9 | JJ | denotes | c |
T2856 | 9-10 | NNS | denotes | t |
T2857 | 10-11 | , | denotes | |
T2858 | 11-12 | JJR | denotes | o |
T2859 | 12-13 | IN | denotes | f |
T2860 | 14-15 | JJ | denotes | t |
T2861 | 15-16 | NN | denotes | h |
T2862 | 16-17 | JJ | denotes | e |
T2863 | 18-19 | NN | denotes | a |
T2864 | 19-31 | sentence | denotes | ltered cathe |
T2865 | 19-20 | RB | denotes | l |
T2866 | 23-25 | VBD | denotes | ed |
T2867 | 21-23 | NNS | denotes | er |
T2868 | 20-21 | NN | denotes | t |
T2869 | 26-27 | VBN | denotes | c |
T2870 | 27-28 | CC | denotes | a |
T2871 | 28-31 | DT | denotes | the |
T2872 | 31-174 | sentence | denotes | psin D processing on enzymatic activity was next tested to determine if altered enzymatic activity accounts for inefficient subunit c turnover. |
T2873 | 31-32 | NN | denotes | p |
T2874 | 80-86 | VBN | denotes | tested |
T2875 | 38-48 | NN | denotes | processing |
T2876 | 32-35 | NN | denotes | sin |
T2877 | 36-37 | NN | denotes | D |
T2878 | 49-51 | IN | denotes | on |
T2879 | 52-61 | JJ | denotes | enzymatic |
T2880 | 62-70 | NN | denotes | activity |
T2881 | 71-74 | VBD | denotes | was |
T2882 | 75-79 | RB | denotes | next |
T2883 | 87-89 | TO | denotes | to |
T2884 | 90-99 | VB | denotes | determine |
T2885 | 100-102 | IN | denotes | if |
T2886 | 130-138 | VBZ | denotes | accounts |
T2887 | 103-110 | VBN | denotes | altered |
T2888 | 121-129 | NN | denotes | activity |
R1700 | T2892 | T2890 | pobj | turnover,for |
R1701 | T2893 | T2894 | compound | subunit,c |
R1702 | T2894 | T2892 | compound | c,turnover |
R1703 | T2895 | T2874 | punct | .,tested |
R1704 | T2897 | T2898 | prep | In,altered |
R1705 | T2899 | T2900 | det | a,assay |
R1706 | T2900 | T2897 | pobj | assay,In |
R1707 | T2901 | T2900 | amod | fluorogenic,assay |
R1708 | T2902 | T2903 | advmod | in,vitro |
R1709 | T2903 | T2900 | amod | vitro,assay |
R1710 | T2904 | T2898 | punct | ", ",altered |
R1711 | T2905 | T2906 | compound | cathepsin,D |
R1712 | T2906 | T2907 | compound | D,activity |
R1713 | T2907 | T2898 | nsubjpass | activity,altered |
R1714 | T2908 | T2907 | prep | in,activity |
R1715 | T2909 | T2910 | amod | total,extracts |
R1716 | T2910 | T2908 | pobj | extracts,in |
R1717 | T2911 | T2910 | amod | cellular,extracts |
R1718 | T2912 | T2898 | auxpass | was,altered |
R1719 | T2913 | T2898 | neg | not,altered |
R1720 | T2914 | T2898 | advmod | significantly,altered |
R1721 | T2915 | T2898 | prep | in,altered |
R1722 | T2916 | T2917 | amod | homozygous,cells |
R1723 | T2917 | T2915 | pobj | cells,in |
R1724 | T2918 | T2917 | nmod | CbCln3Δex7,cells |
R1725 | T2919 | T2918 | punct | /,CbCln3Δex7 |
R1726 | T2920 | T2918 | nummod | 8,CbCln3Δex7 |
R1727 | T2921 | T2922 | punct | (,RFU |
R1728 | T2922 | T2917 | parataxis | RFU,cells |
R1729 | T2923 | T2924 | quantmod | 376,89 |
R1730 | T2924 | T2922 | nummod | 89,RFU |
R1731 | T2925 | T2924 | punct | ±,89 |
R1732 | T2926 | T2927 | punct | /,protein |
R1733 | T2927 | T2922 | prep | protein,RFU |
R1734 | T2928 | T2927 | nmod | μg,protein |
R1735 | T2929 | T2927 | amod | total,protein |
R1736 | T2930 | T2922 | punct | ),RFU |
R1737 | T2931 | T2917 | punct | ", ",cells |
R1738 | T2932 | T2917 | cc | versus,cells |
R1739 | T2933 | T2934 | amod | wild,type |
R1740 | T2934 | T2936 | compound | type,cells |
R1741 | T2935 | T2934 | punct | -,type |
R1742 | T2936 | T2917 | conj | cells,cells |
R1743 | T2937 | T2938 | punct | (,RFU |
R1744 | T2938 | T2936 | parataxis | RFU,cells |
R1745 | T2939 | T2940 | quantmod | 324,58 |
R1746 | T2940 | T2938 | nummod | 58,RFU |
R1747 | T2941 | T2940 | quantmod | ±,58 |
R1748 | T2942 | T2943 | punct | /,protein |
R1749 | T2943 | T2938 | prep | protein,RFU |
R1750 | T2944 | T2943 | nmod | μg,protein |
R1751 | T2945 | T2943 | amod | total,protein |
R1752 | T2946 | T2938 | punct | ),RFU |
R1753 | T2947 | T2898 | punct | ", ",altered |
R1754 | T2948 | T2949 | mark | although,observed |
R1755 | T2949 | T2898 | advcl | observed,altered |
R1756 | T2950 | T2951 | det | a,trend |
R1757 | T2951 | T2949 | nsubjpass | trend,observed |
R1758 | T2952 | T2951 | amod | consistent,trend |
R1759 | T2953 | T2951 | prep | towards,trend |
R1760 | T2954 | T2955 | amod | increased,activity |
R1761 | T2955 | T2953 | pobj | activity,towards |
R1762 | T2956 | T2955 | amod | enzymatic,activity |
R1763 | T2957 | T2955 | prep | in,activity |
R1764 | T2958 | T2959 | compound | mutant,cells |
R1765 | T2959 | T2957 | pobj | cells,in |
R1766 | T2960 | T2949 | auxpass | was,observed |
R1767 | T2961 | T2898 | punct | .,altered |
R1768 | T2963 | T2964 | advmod | Thus,disrupted |
R1769 | T2965 | T2964 | punct | ", ",disrupted |
R1770 | T2966 | T2967 | compound | cathepsin,D |
R1771 | T2967 | T2964 | nsubjpass | D,disrupted |
R1772 | T2968 | T2967 | appos | transport,D |
R1773 | T2969 | T2968 | cc | and,transport |
R1774 | T2970 | T2968 | conj | processing,transport |
R1775 | T2971 | T2964 | auxpass | are,disrupted |
R1776 | T2972 | T2964 | prep | in,disrupted |
R1777 | T2973 | T2974 | amod | homozygous,cells |
R1778 | T2974 | T2972 | pobj | cells,in |
R1779 | T2975 | T2974 | nmod | CbCln3Δex7,cells |
R1780 | T2976 | T2975 | punct | /,CbCln3Δex7 |
R1781 | T2977 | T2975 | nummod | 8,CbCln3Δex7 |
R1782 | T2978 | T2964 | prep | in,disrupted |
R1783 | T2979 | T2980 | det | a,manner |
R1784 | T2980 | T2978 | pobj | manner,in |
R1785 | T2981 | T2980 | amod | such,manner |
R1786 | T2982 | T2983 | mark | that,appears |
R1787 | T2983 | T2981 | ccomp | appears,such |
R1788 | T2984 | T2985 | amod | enzymatic,activity |
R1789 | T2985 | T2983 | nsubj | activity,appears |
R1790 | T2986 | T2987 | aux | to,be |
R1791 | T2987 | T2983 | xcomp | be,appears |
R1792 | T2988 | T2989 | advmod | relatively,unaffected |
R1793 | T2989 | T2987 | acomp | unaffected,be |
R1794 | T2990 | T2964 | punct | .,disrupted |
R1687 | T2879 | T2880 | amod | enzymatic,activity |
R1688 | T2880 | T2878 | pobj | activity,on |
R1689 | T2881 | T2874 | auxpass | was,tested |
R1690 | T2882 | T2874 | advmod | next,tested |
R1691 | T2883 | T2884 | aux | to,determine |
R1692 | T2884 | T2874 | advcl | determine,tested |
R1693 | T2885 | T2886 | mark | if,accounts |
R1694 | T2886 | T2884 | ccomp | accounts,determine |
R1695 | T2887 | T2888 | amod | altered,activity |
R1696 | T2888 | T2886 | nsubj | activity,accounts |
R1697 | T2889 | T2888 | amod | enzymatic,activity |
R1698 | T2890 | T2886 | prep | for,accounts |
R1699 | T2891 | T2892 | amod | inefficient,turnover |
R1678 | T2855 | T2856 | amod | c,t |
R1679 | T2862 | T2863 | amod | e,a |
R1680 | T2865 | T2866 | advmod | l,ed |
R1681 | T2867 | T2866 | nsubj | er,ed |
R1682 | T2868 | T2867 | nmod | t,er |
R1683 | T2873 | T2874 | nsubjpass | p,tested |
R1684 | T2876 | T2877 | compound | sin,D |
R1685 | T2877 | T2875 | compound | D,processing |
R1686 | T2878 | T2873 | prep | on,p |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2497 | 4-5 | PR_EXT:000006025 | denotes | i |
T2498 | 6-7 | SO_EXT:wild_type_entity_or_quality | denotes | p |
T2499 | 8-9 | CL_GO_EXT:cell | denotes | c |
T2500 | 20-21 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | t |
T2501 | 32-37 | PR_EXT:000006025 | denotes | sin D |
T2502 | 38-48 | SO_EXT:sequence_alteration_process | denotes | processing |
T2503 | 52-61 | CHEBI_GO_SO_EXT:enzyme | denotes | enzymatic |
T2504 | 111-120 | CHEBI_GO_SO_EXT:enzyme | denotes | enzymatic |
T2505 | 155-164 | PR_EXT:000022190 | denotes | subunit c |
T2506 | 180-191 | CHEBI_EXT:76219 | denotes | fluorogenic |
T2507 | 208-219 | PR_EXT:000006025 | denotes | cathepsin D |
T2508 | 238-246 | CL_GO_EXT:cell | denotes | cellular |
T2509 | 300-302 | UBERON:0002037 | denotes | Cb |
T2510 | 302-306 | PR_EXT:000005591 | denotes | Cln3 |
T2511 | 313-318 | CL_GO_EXT:cell | denotes | cells |
T2512 | 342-349 | CHEBI_PR_EXT:protein | denotes | protein |
T2513 | 359-368 | SO_EXT:wild_type_entity_or_quality | denotes | wild-type |
T2514 | 369-374 | CL_GO_EXT:cell | denotes | cells |
T2515 | 398-405 | CHEBI_PR_EXT:protein | denotes | protein |
T2516 | 454-463 | CHEBI_GO_SO_EXT:enzyme | denotes | enzymatic |
T2517 | 476-482 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | mutant |
T2518 | 483-488 | CL_GO_EXT:cell | denotes | cells |
T2519 | 509-520 | PR_EXT:000006025 | denotes | cathepsin D |
T2520 | 521-530 | GO_EXT:biological_routing_or_transport | denotes | transport |
T2521 | 535-545 | SO_EXT:sequence_alteration_process | denotes | processing |
T2522 | 574-576 | UBERON:0002037 | denotes | Cb |
T2523 | 576-580 | PR_EXT:000005591 | denotes | Cln3 |
T2524 | 587-592 | CL_GO_EXT:cell | denotes | cells |
T2525 | 615-624 | CHEBI_GO_SO_EXT:enzyme | denotes | enzymatic |