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PMC:539297 / 11900-15419 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2386 757-759 UBERON:0002037 denotes Cb
T2387 759-763 PR:000005591 denotes Cln3
T2388 777-788 PR:000006025 denotes cathepsin D
T2389 811-820 GO:0031982 denotes vesicular
T2390 834-841 GO:0005634 denotes nuclear
T2391 903-905 UBERON:0002037 denotes Cb
T2392 905-909 PR:000005591 denotes Cln3
T2393 925-929 PR:000005591 denotes Cln3
T2394 936-942 UBERON:0000479 denotes tissue
T2395 991-1002 PR:000006025 denotes cathepsin D
T2396 1003-1011 SO:0001060 denotes isoforms
T2397 1023-1034 PR:000006025 denotes Cathepsin D
T2398 1035-1043 SO:0001060 denotes isoforms
T2399 1145-1157 SO:0000984 denotes single chain
T2400 1212-1224 SO:0000985 denotes double-chain
T2401 1271-1273 UBERON:0002037 denotes Cb
T2402 1273-1277 PR:000005591 denotes Cln3
T2403 1293-1297 PR:000005591 denotes Cln3
T2404 1304-1310 UBERON:0000479 denotes tissue
T2405 1501-1512 PR:000006025 denotes cathepsin D
T2406 1573-1577 PR:000005591 denotes Cln3
T2407 1584-1588 NCBITaxon:10088 denotes mice
T2408 1593-1595 UBERON:0002037 denotes Cb
T2409 1595-1599 PR:000005591 denotes Cln3
T2410 2853-2854 PR:000006025 denotes i
T2411 2881-2886 PR:000006025 denotes sin D
T2412 3004-3013 PR:000022190 denotes subunit c
T2413 3029-3040 CHEBI:76219 denotes fluorogenic
T2414 3057-3068 PR:000006025 denotes cathepsin D
T2415 3149-3151 UBERON:0002037 denotes Cb
T2416 3151-3155 PR:000005591 denotes Cln3
T2417 3358-3369 PR:000006025 denotes cathepsin D
T2418 3423-3425 UBERON:0002037 denotes Cb
T2419 3425-3429 PR:000005591 denotes Cln3
T9165 1725-1736 PR:000006025 denotes Cathepsin D
T9166 1793-1795 UBERON:0002037 denotes Cb
T9167 1795-1799 PR:000005591 denotes Cln3
T9168 1858-1860 UBERON:0002037 denotes Cb
T9169 1860-1864 PR:000005591 denotes Cln3
T9170 1897-1908 PR:000006025 denotes cathepsin D
T9171 1909-1917 GO:0042571 denotes antibody
T9172 1966-1977 PR:000006025 denotes cathepsin D
T9173 1996-1998 UBERON:0002037 denotes Cb
T9174 1998-2002 PR:000005591 denotes Cln3
T9175 2041-2048 GO:0005634 denotes nuclear
T9176 2053-2064 GO:0005737 denotes cytoplasmic
T9177 2082-2093 PR:000006025 denotes Cathepsin D
T9178 2115-2117 UBERON:0002037 denotes Cb
T9179 2117-2121 PR:000005591 denotes Cln3
T9180 2167-2174 GO:0005634 denotes nuclear
T9181 2186-2197 GO:0005737 denotes cytoplasmic
T9182 2237-2239 UBERON:0002037 denotes Cb
T9183 2239-2243 PR:000005591 denotes Cln3
T9184 2279-2290 PR:000006025 denotes Cathepsin D
T9185 2347-2351 PR:000005591 denotes Cln3
T9186 2367-2373 UBERON:0000479 denotes tissue
T9187 2377-2379 UBERON:0002037 denotes Cb
T9188 2379-2383 PR:000005591 denotes Cln3
T9189 2431-2442 PR:000006025 denotes cathepsin D
T9190 2516-2522 UBERON:0000479 denotes tissue
T9191 2655-2659 PR:000005591 denotes Cln3
T9192 2670-2672 UBERON:0002037 denotes Cb
T9193 2672-2676 PR:000005591 denotes Cln3
T9194 2764-2776 SO:0000985 denotes double-chain
T9195 2821-2833 SO:0000984 denotes single-chain
T2362 11-13 UBERON:0002037 denotes Cb
T2363 13-17 PR:000005591 denotes Cln3
T2364 34-38 PR:000005591 denotes Cln3
T2365 54-58 NCBITaxon:10088 denotes mice
T2366 67-78 PR:000006025 denotes cathepsin D
T2367 125-134 PR:000022190 denotes subunit c
T2368 177-188 PR:000006025 denotes cathepsin D
T2369 226-248 PR:000022190 denotes ATP synthase subunit c
T2370 268-276 GO:0005764 denotes lysosome
T2371 299-310 PR:000006025 denotes cathepsin D
T2372 350-352 UBERON:0002037 denotes Cb
T2373 352-356 PR:000005591 denotes Cln3
T2374 373-377 PR:000005591 denotes Cln3
T2375 384-388 NCBITaxon:10088 denotes mice
T2376 400-411 PR:000006025 denotes cathepsin D
T2377 412-420 GO:0042571 denotes antibody
T2378 463-474 PR:000006025 denotes cathepsin D
T2379 475-483 SO:0001060 denotes isoforms
T2380 528-530 UBERON:0002037 denotes Cb
T2381 530-534 PR:000005591 denotes Cln3
T2382 562-569 GO:0005634 denotes nuclear
T2383 583-592 GO:0031982 denotes vesicular
T2384 593-604 PR:000006025 denotes cathepsin D
T2385 714-722 GO:0005764 denotes lysosome

craft-sa-dev

Id Subject Object Predicate Lexical cue
T2526 0-10 JJ denotes Homozygous
T2527 24-29 NNS denotes cells
T2528 11-21 NN denotes CbCln3Δex7
T2529 21-22 HYPH denotes /
T2530 22-23 CD denotes 8
T2531 59-66 VBP denotes process
T2532 30-33 CC denotes and
T2533 34-42 NN denotes Cln3Δex7
T2534 54-58 NNS denotes mice
T2535 42-43 HYPH denotes /
T2536 43-44 CD denotes 8
T2537 45-50 VB denotes knock
T2538 50-51 HYPH denotes -
T2539 51-53 RP denotes in
T2540 67-76 NN denotes cathepsin
T2541 77-78 NN denotes D
T2542 79-89 RB denotes abnormally
T2543 89-282 sentence denotes We next investigated the basis for subunit c accumulation, testing the hypothesis that cathepsin D is abnormal since it is required for ATP synthase subunit c degradation in the lysosome [13].
T2544 90-92 PRP denotes We
T2545 98-110 VBD denotes investigated
T2546 93-97 RB denotes next
T2547 111-114 DT denotes the
T2548 115-120 NN denotes basis
T2549 121-124 IN denotes for
T2550 125-132 NN denotes subunit
T2551 133-134 NN denotes c
T2552 135-147 NN denotes accumulation
T2553 147-149 , denotes ,
T2554 149-156 VBG denotes testing
T2555 157-160 DT denotes the
T2556 161-171 NN denotes hypothesis
T2557 172-176 IN denotes that
T2558 189-191 VBZ denotes is
T2559 177-186 NN denotes cathepsin
T2560 187-188 NN denotes D
T2561 192-200 JJ denotes abnormal
T2562 201-206 IN denotes since
T2563 210-212 VBZ denotes is
T2564 207-209 PRP denotes it
T2565 213-221 JJ denotes required
T2566 222-225 IN denotes for
T2567 226-229 NN denotes ATP
T2568 249-260 NN denotes degradation
T2569 230-238 NN denotes synthase
T2570 239-246 NN denotes subunit
T2571 247-248 NN denotes c
T2572 261-263 IN denotes in
T2573 264-267 DT denotes the
T2574 268-276 NN denotes lysosome
T2575 277-278 -LRB- denotes [
T2576 278-280 CD denotes 13
T2577 280-281 -RRB- denotes ]
T2578 281-282 . denotes .
T2579 282-484 sentence denotes We first tested cathepsin D transport and processing in homozygous CbCln3Δex7/8 cells and Cln3Δex7/8 mice using anti-cathepsin D antibody that recognizes unprocessed and processed cathepsin D isoforms.
T2580 283-285 PRP denotes We
T2581 292-298 VBD denotes tested
T2582 286-291 RB denotes first
T2583 299-308 NN denotes cathepsin
T2584 309-310 NN denotes D
T2585 311-320 NN denotes transport
T2586 321-324 CC denotes and
T2587 325-335 NN denotes processing
T2588 336-338 IN denotes in
T2589 339-349 JJ denotes homozygous
T2590 363-368 NNS denotes cells
T2591 350-360 NN denotes CbCln3Δex7
T2592 360-361 HYPH denotes /
T2593 361-362 CD denotes 8
T2594 369-372 CC denotes and
T2595 373-381 NN denotes Cln3Δex7
T2596 384-388 NNS denotes mice
T2597 381-382 HYPH denotes /
T2598 382-383 CD denotes 8
T2599 389-394 VBG denotes using
T2600 395-409 JJ denotes anti-cathepsin
T2601 410-411 NN denotes D
T2602 412-420 NN denotes antibody
T2603 421-425 WDT denotes that
T2604 426-436 VBZ denotes recognizes
T2605 437-448 JJ denotes unprocessed
T2606 475-483 NNS denotes isoforms
T2607 449-452 CC denotes and
T2608 453-462 VBN denotes processed
T2609 463-472 NN denotes cathepsin
T2610 473-474 NN denotes D
T2611 483-484 . denotes .
T2612 484-733 sentence denotes Immunostaining of wild-type and homozygous CbCln3Δex7/8 cells revealed a perinuclear and punctate vesicular cathepsin D distribution, consistent with its transport and processing through the secretory pathway and delivery to the lysosome (Fig. 5a).
T2613 485-499 NN denotes Immunostaining
T2614 547-555 VBD denotes revealed
T2615 500-502 IN denotes of
T2616 503-507 JJ denotes wild
T2617 508-512 NN denotes type
T2618 507-508 HYPH denotes -
T2619 541-546 NNS denotes cells
T2620 513-516 CC denotes and
T2621 517-527 JJ denotes homozygous
T2622 528-538 NN denotes CbCln3Δex7
T2623 538-539 HYPH denotes /
T2624 539-540 CD denotes 8
T2625 556-557 DT denotes a
T2626 605-617 NN denotes distribution
T2627 558-569 JJ denotes perinuclear
T2628 570-573 CC denotes and
T2629 574-582 JJ denotes punctate
T2630 583-592 JJ denotes vesicular
T2631 593-602 NN denotes cathepsin
T2632 603-604 NN denotes D
T2633 617-619 , denotes ,
T2634 619-629 JJ denotes consistent
T2635 630-634 IN denotes with
T2636 635-638 PRP$ denotes its
T2637 639-648 NN denotes transport
T2638 649-652 CC denotes and
T2639 653-663 NN denotes processing
T2640 664-671 IN denotes through
T2641 672-675 DT denotes the
T2642 686-693 NN denotes pathway
T2643 676-685 JJ denotes secretory
T2644 694-697 CC denotes and
T2645 698-706 NN denotes delivery
T2646 707-709 IN denotes to
T2647 710-713 DT denotes the
T2648 714-722 NN denotes lysosome
T2649 723-724 -LRB- denotes (
T2650 729-731 NN denotes 5a
T2651 724-728 NN denotes Fig.
T2652 731-732 -RRB- denotes )
T2653 732-733 . denotes .
T2654 733-876 sentence denotes However, in homozygous CbCln3Δex7/8 cells, cathepsin D distribution was less vesicular and more perinuclear-clustered than in wild-type cells.
T2655 734-741 RB denotes However
T2656 802-805 VBD denotes was
T2657 741-743 , denotes ,
T2658 743-745 IN denotes in
T2659 746-756 JJ denotes homozygous
T2660 770-775 NNS denotes cells
T2661 757-767 NN denotes CbCln3Δex7
T2662 767-768 HYPH denotes /
T2663 768-769 CD denotes 8
T2664 775-777 , denotes ,
T2665 777-786 NN denotes cathepsin
T2666 787-788 NN denotes D
T2667 789-801 NN denotes distribution
T2668 806-810 RBR denotes less
T2669 811-820 JJ denotes vesicular
T2670 821-824 CC denotes and
T2671 825-829 RBR denotes more
T2672 842-851 VBN denotes clustered
T2673 830-841 JJ denotes perinuclear
T2674 841-842 HYPH denotes -
T2675 852-856 IN denotes than
T2676 857-859 IN denotes in
T2677 860-864 JJ denotes wild
T2678 865-869 NN denotes type
T2679 864-865 HYPH denotes -
T2680 870-875 NNS denotes cells
T2681 875-876 . denotes .
T2682 876-1022 sentence denotes Immunoblots of homozygous CbCln3Δex7/8 cell and Cln3Δex7/8 tissue extracts also showed altered relative levels of cathepsin D isoforms (Fig. 5b).
T2683 877-888 NNS denotes Immunoblots
T2684 957-963 VBD denotes showed
T2685 889-891 IN denotes of
T2686 892-902 JJ denotes homozygous
T2687 943-951 NNS denotes extracts
T2688 903-913 NN denotes CbCln3Δex7
T2689 916-920 NN denotes cell
T2690 913-914 HYPH denotes /
T2691 914-915 CD denotes 8
T2692 921-924 CC denotes and
T2693 925-933 NN denotes Cln3Δex7
T2694 936-942 NN denotes tissue
T2695 933-934 HYPH denotes /
T2696 934-935 CD denotes 8
T2697 952-956 RB denotes also
T2698 964-971 VBN denotes altered
T2699 981-987 NNS denotes levels
T2700 972-980 JJ denotes relative
T2701 988-990 IN denotes of
T2702 991-1000 NN denotes cathepsin
T2703 1001-1002 NN denotes D
T2704 1003-1011 NNS denotes isoforms
T2705 1012-1013 -LRB- denotes (
T2706 1018-1020 NN denotes 5b
T2707 1013-1017 NN denotes Fig.
T2708 1020-1021 -RRB- denotes )
T2709 1021-1022 . denotes .
T2710 1022-1256 sentence denotes Cathepsin D isoforms, identified by relative molecular weights, represent the ~45 kDa precursor, the ~43 kDa intermediate single chain form of the enzyme, and the 31 kDa heavy chain of the double-chain form of the mature enzyme [14].
T2711 1023-1032 NN denotes Cathepsin
T2712 1033-1034 NN denotes D
T2713 1035-1043 NNS denotes isoforms
T2714 1087-1096 VBP denotes represent
T2715 1043-1045 , denotes ,
T2716 1045-1055 VBN denotes identified
T2717 1056-1058 IN denotes by
T2718 1059-1067 JJ denotes relative
T2719 1078-1085 NNS denotes weights
T2720 1068-1077 JJ denotes molecular
T2721 1085-1087 , denotes ,
T2722 1097-1100 DT denotes the
T2723 1109-1118 NN denotes precursor
T2724 1101-1102 SYM denotes ~
T2725 1102-1104 CD denotes 45
T2726 1105-1108 NN denotes kDa
T2727 1118-1120 , denotes ,
T2728 1120-1123 DT denotes the
T2729 1158-1162 NN denotes form
T2730 1124-1125 SYM denotes ~
T2731 1125-1127 CD denotes 43
T2732 1128-1131 NN denotes kDa
T2733 1132-1144 JJ denotes intermediate
T2734 1145-1151 JJ denotes single
T2735 1152-1157 NN denotes chain
T2736 1163-1165 IN denotes of
T2737 1166-1169 DT denotes the
T2738 1170-1176 NN denotes enzyme
T2739 1176-1178 , denotes ,
T2740 1178-1181 CC denotes and
T2741 1182-1185 DT denotes the
T2742 1199-1204 NN denotes chain
T2743 1186-1188 CD denotes 31
T2744 1189-1192 NN denotes kDa
T2745 1193-1198 JJ denotes heavy
T2746 1205-1207 IN denotes of
T2747 1208-1211 DT denotes the
T2748 1225-1229 NN denotes form
T2749 1212-1218 JJ denotes double
T2750 1219-1224 NN denotes chain
T2751 1218-1219 HYPH denotes -
T2752 1230-1232 IN denotes of
T2753 1233-1236 DT denotes the
T2754 1244-1250 NN denotes enzyme
T2755 1237-1243 JJ denotes mature
T2756 1251-1252 -LRB- denotes [
T2757 1252-1254 CD denotes 14
T2758 1254-1255 -RRB- denotes ]
T2759 1255-1256 . denotes .
T2760 1256-1440 sentence denotes In homozygous CbCln3Δex7/8 cell and Cln3Δex7/8 tissue extracts, the precursor and heavy chains were reduced, and the single chain was slightly elevated compared to wild-type extracts.
T2761 1257-1259 IN denotes In
T2762 1357-1364 VBN denotes reduced
T2763 1260-1270 JJ denotes homozygous
T2764 1311-1319 NNS denotes extracts
T2765 1271-1281 NN denotes CbCln3Δex7
T2766 1284-1288 NN denotes cell
T2767 1281-1282 HYPH denotes /
T2768 1282-1283 CD denotes 8
T2769 1289-1292 CC denotes and
T2770 1293-1301 NN denotes Cln3Δex7
T2771 1304-1310 NN denotes tissue
T2772 1301-1302 HYPH denotes /
T2773 1302-1303 CD denotes 8
T2774 1319-1321 , denotes ,
T2775 1321-1324 DT denotes the
T2776 1325-1334 NN denotes precursor
T2777 1335-1338 CC denotes and
T2778 1339-1344 JJ denotes heavy
T2779 1345-1351 NNS denotes chains
T2780 1352-1356 VBD denotes were
T2781 1364-1366 , denotes ,
T2782 1366-1369 CC denotes and
T2783 1370-1373 DT denotes the
T2784 1381-1386 NN denotes chain
T2785 1374-1380 JJ denotes single
T2786 1387-1390 VBD denotes was
T2787 1391-1399 RB denotes slightly
T2788 1400-1408 JJ denotes elevated
T2789 1409-1417 VBN denotes compared
T2790 1418-1420 IN denotes to
T2838 1667-1668 DT denotes a
T2839 1687-1696 NN denotes phenotype
T2840 1669-1678 JJ denotes recessive
T2841 1679-1686 NN denotes disease
T2842 1697-1698 -LRB- denotes (
T2843 1707-1712 VBN denotes shown
T2844 1698-1702 NNS denotes data
T2845 1703-1706 RB denotes not
T2846 1712-1713 -RRB- denotes )
T2847 1713-1714 . denotes .
T2848 1714-1715 sentence denotes
T2889 2960-2969 JJ denotes enzymatic
T2890 2988-2991 IN denotes for
T2891 2992-3003 JJ denotes inefficient
T2892 3014-3022 NN denotes turnover
T2893 3004-3011 NN denotes subunit
T2894 3012-3013 NN denotes c
T2895 3022-3023 . denotes .
T2896 3023-3351 sentence denotes In a fluorogenic in vitro assay, cathepsin D activity in total cellular extracts was not significantly altered in homozygous CbCln3Δex7/8 cells (376 ± 89 RFU/μg total protein), versus wild-type cells (324 ± 58 RFU/μg total protein), although a consistent trend towards increased enzymatic activity in mutant cells was observed.
T2897 3024-3026 IN denotes In
T2898 3127-3134 VBN denotes altered
T2899 3027-3028 DT denotes a
T2900 3050-3055 NN denotes assay
T2901 3029-3040 JJ denotes fluorogenic
T2902 3041-3043 FW denotes in
T2903 3044-3049 FW denotes vitro
T2904 3055-3057 , denotes ,
T2905 3057-3066 NN denotes cathepsin
T2906 3067-3068 NN denotes D
T2907 3069-3077 NN denotes activity
T2908 3078-3080 IN denotes in
T2909 3081-3086 JJ denotes total
T2910 3096-3104 NNS denotes extracts
T2911 3087-3095 JJ denotes cellular
T2912 3105-3108 VBD denotes was
T2913 3109-3112 RB denotes not
T2914 3113-3126 RB denotes significantly
T2915 3135-3137 IN denotes in
T2916 3138-3148 JJ denotes homozygous
T2917 3162-3167 NNS denotes cells
T2918 3149-3159 NN denotes CbCln3Δex7
T2919 3159-3160 HYPH denotes /
T2920 3160-3161 CD denotes 8
T2921 3168-3169 -LRB- denotes (
T2922 3178-3181 NN denotes RFU
T2923 3169-3172 CD denotes 376
T2924 3175-3177 CD denotes 89
T2925 3173-3174 SYM denotes ±
T2926 3181-3182 SYM denotes /
T2927 3191-3198 NN denotes protein
T2928 3182-3184 NN denotes μg
T2929 3185-3190 JJ denotes total
T2930 3198-3199 -RRB- denotes )
T2931 3199-3201 , denotes ,
T2932 3201-3207 CC denotes versus
T2933 3208-3212 JJ denotes wild
T2934 3213-3217 NN denotes type
T2935 3212-3213 HYPH denotes -
T2936 3218-3223 NNS denotes cells
T2937 3224-3225 -LRB- denotes (
T2938 3234-3237 NN denotes RFU
T2939 3225-3228 CD denotes 324
T2940 3231-3233 CD denotes 58
T2941 3229-3230 IN denotes ±
T2942 3237-3238 SYM denotes /
T2943 3247-3254 NN denotes protein
T2944 3238-3240 NN denotes μg
T2945 3241-3246 JJ denotes total
T2946 3254-3255 -RRB- denotes )
T2947 3255-3257 , denotes ,
T2948 3257-3265 IN denotes although
T2949 3342-3350 VBN denotes observed
T2950 3266-3267 DT denotes a
T2951 3279-3284 NN denotes trend
T2952 3268-3278 JJ denotes consistent
T2953 3285-3292 IN denotes towards
T2954 3293-3302 VBN denotes increased
T2955 3313-3321 NN denotes activity
T2956 3303-3312 JJ denotes enzymatic
T2957 3322-3324 IN denotes in
T2958 3325-3331 NN denotes mutant
T2959 3332-3337 NNS denotes cells
T2960 3338-3341 VBD denotes was
T2961 3350-3351 . denotes .
T2962 3351-3519 sentence denotes Thus, cathepsin D transport and processing are disrupted in homozygous CbCln3Δex7/8 cells in a manner such that enzymatic activity appears to be relatively unaffected.
T2963 3352-3356 RB denotes Thus
T2964 3399-3408 VBN denotes disrupted
T2965 3356-3358 , denotes ,
T2966 3358-3367 NN denotes cathepsin
T2967 3368-3369 NN denotes D
T2968 3370-3379 NN denotes transport
T2969 3380-3383 CC denotes and
T2970 3384-3394 NN denotes processing
T2971 3395-3398 VBP denotes are
T2972 3409-3411 IN denotes in
T2973 3412-3422 JJ denotes homozygous
T2974 3436-3441 NNS denotes cells
T2975 3423-3433 NN denotes CbCln3Δex7
T2976 3433-3434 HYPH denotes /
T2977 3434-3435 CD denotes 8
T2978 3442-3444 IN denotes in
T2979 3445-3446 DT denotes a
T2980 3447-3453 NN denotes manner
T2981 3454-3458 JJ denotes such
T2982 3459-3463 IN denotes that
T2983 3483-3490 VBZ denotes appears
T2984 3464-3473 JJ denotes enzymatic
T2985 3474-3482 NN denotes activity
T2986 3491-3493 TO denotes to
T2987 3494-3496 VB denotes be
T2988 3497-3507 RB denotes relatively
T2989 3508-3518 JJ denotes unaffected
T2990 3518-3519 . denotes .
T9254 1725-1734 NN denotes Cathepsin
T9255 1735-1736 NN denotes D
T9256 1737-1749 NN denotes localization
T9257 1750-1753 CC denotes and
T9258 1754-1764 NN denotes processing
T9259 1765-1767 IN denotes in
T9260 1768-1772 JJ denotes wild
T9261 1773-1777 NN denotes type
T9262 1772-1773 HYPH denotes -
T9263 1806-1811 NNS denotes cells
T9264 1778-1781 CC denotes and
T9265 1782-1792 JJ denotes homozygous
T9266 1793-1803 NN denotes CbCln3Δex7
T9267 1803-1804 HYPH denotes /
T9268 1804-1805 CD denotes 8
T9269 1811-1995 sentence denotes a. Immunostaining of wild-type and homozygous CbCln3Δex7/8 precursor cells with anti-cathepsin D antibody, recognizing unprocessed and processed forms of cathepsin D protein is shown.
T9270 1812-1813 LS denotes a
T9271 1989-1994 VBN denotes shown
T9272 1813-1814 . denotes .
T9273 1815-1829 NN denotes Immunostaining
T9274 1830-1832 IN denotes of
T9275 1833-1837 JJ denotes wild
T9276 1838-1842 NN denotes type
T9277 1837-1838 HYPH denotes -
T9278 1881-1886 NNS denotes cells
T9279 1843-1846 CC denotes and
T9280 1847-1857 JJ denotes homozygous
T9281 1858-1868 NN denotes CbCln3Δex7
T9282 1868-1869 HYPH denotes /
T9283 1869-1870 CD denotes 8
T9284 1871-1880 NN denotes precursor
T9285 1887-1891 IN denotes with
T9286 1892-1906 JJ denotes anti-cathepsin
T9287 1907-1908 NN denotes D
T9288 1909-1917 NN denotes antibody
T9289 1917-1919 , denotes ,
T9290 1919-1930 VBG denotes recognizing
T9291 1931-1942 JJ denotes unprocessed
T9292 1957-1962 NNS denotes forms
T9293 1943-1946 CC denotes and
T9294 1947-1956 VBN denotes processed
T9295 1963-1965 IN denotes of
T9296 1966-1975 NN denotes cathepsin
T9297 1976-1977 NN denotes D
T9298 1978-1985 NN denotes protein
T9299 1986-1988 VBZ denotes is
T9300 1994-1995 . denotes .
T9301 1995-2081 sentence denotes CbCln3+/+ cells (left panel) exhibited a perinuclear and cytoplasmic punctate signal.
T9302 1996-2002 NN denotes CbCln3
T9303 2006-2011 NNS denotes cells
T9304 2002-2003 SYM denotes +
T9305 2003-2004 HYPH denotes /
T9306 2004-2005 SYM denotes +
T9307 2025-2034 VBD denotes exhibited
T9308 2012-2013 -LRB- denotes (
T9309 2018-2023 NN denotes panel
T9310 2013-2017 JJ denotes left
T9311 2023-2024 -RRB- denotes )
T9312 2035-2036 DT denotes a
T9313 2074-2080 NN denotes signal
T9314 2037-2048 JJ denotes perinuclear
T9315 2049-2052 CC denotes and
T9316 2053-2064 JJ denotes cytoplasmic
T9317 2065-2073 JJ denotes punctate
T9318 2080-2081 . denotes .
T9319 2081-2253 sentence denotes Cathepsin D signal in homozygous CbCln3Δex7/8 cells (right panel) was more often perinuclear, with less cytoplasmic punctate signal, compared to wild-type CbCln3+/+ cells.
T9320 2082-2091 NN denotes Cathepsin
T9321 2092-2093 NN denotes D
T9322 2094-2100 NN denotes signal
T9323 2148-2151 VBD denotes was
T9324 2101-2103 IN denotes in
T9325 2104-2114 JJ denotes homozygous
T9326 2128-2133 NNS denotes cells
T9327 2115-2125 NN denotes CbCln3Δex7
T9328 2125-2126 HYPH denotes /
T9329 2126-2127 CD denotes 8
T9330 2134-2135 -LRB- denotes (
T9331 2141-2146 NN denotes panel
T9332 2135-2140 JJ denotes right
T9333 2146-2147 -RRB- denotes )
T9334 2152-2156 RBR denotes more
T9335 2157-2162 RB denotes often
T9336 2163-2174 JJ denotes perinuclear
T9337 2174-2176 , denotes ,
T9338 2176-2180 IN denotes with
T9339 2181-2185 RBR denotes less
T9340 2207-2213 NN denotes signal
T9341 2186-2197 JJ denotes cytoplasmic
T9342 2198-2206 NN denotes punctate
T9343 2213-2215 , denotes ,
T9344 2215-2223 VBN denotes compared
T9345 2224-2226 IN denotes to
T9346 2227-2231 JJ denotes wild
T9347 2232-2236 NN denotes type
T9348 2231-2232 HYPH denotes -
T9349 2247-2252 NNS denotes cells
T9350 2237-2243 NN denotes CbCln3
T9351 2243-2244 SYM denotes +
T9352 2244-2245 HYPH denotes /
T9353 2245-2246 SYM denotes +
T9354 2252-2253 . denotes .
T9355 2253-2273 sentence denotes 40 × magnification.
T9356 2254-2256 CD denotes 40
T9357 2259-2272 NN denotes magnification
T9358 2257-2258 SYM denotes ×
T9359 2272-2273 . denotes .
T9360 2273-2418 sentence denotes b. α-Cathepsin D-probed immunoblots of total wild-type versus homozygous Cln3Δex7/8 knock-in tissue or CbCln3Δex7/8 cellular extracts are shown.
T9361 2274-2275 LS denotes b
T9362 2412-2417 VBN denotes shown
T9363 2275-2276 . denotes .
T9364 2277-2278 NN denotes α
T9365 2289-2290 NN denotes D
T9366 2278-2279 HYPH denotes -
T9367 2279-2288 NN denotes Cathepsin
T9368 2291-2297 VBN denotes probed
T9369 2290-2291 HYPH denotes -
T9370 2298-2309 NNS denotes immunoblots
T9371 2310-2312 IN denotes of
T9372 2313-2318 JJ denotes total
T9373 2367-2373 NN denotes tissue
T9374 2319-2323 JJ denotes wild
T9375 2324-2328 NN denotes type
T9376 2323-2324 HYPH denotes -
T9377 2329-2335 CC denotes versus
T9378 2336-2346 JJ denotes homozygous
T9379 2347-2355 NN denotes Cln3Δex7
T9380 2358-2363 VB denotes knock
T9381 2355-2356 HYPH denotes /
T9382 2356-2357 CD denotes 8
T9383 2363-2364 HYPH denotes -
T9384 2364-2366 RP denotes in
T9385 2374-2376 CC denotes or
T9386 2377-2387 NN denotes CbCln3Δex7
T9387 2399-2407 NNS denotes extracts
T9388 2387-2388 HYPH denotes /
T9389 2388-2389 CD denotes 8
T9390 2390-2398 JJ denotes cellular
T9391 2408-2411 VBP denotes are
T9392 2417-2418 . denotes .
T9393 2418-2631 sentence denotes The ~45 kDa cathepsin D band, representing precursor, was the predominant band in wild-type (wt) tissue and cellular extracts, with lower levels of mature enzyme (single chain, ~43 kDa, and heavy chain, ~31 kDa).
T9394 2419-2422 DT denotes The
T9395 2443-2447 NN denotes band
T9396 2423-2424 SYM denotes ~
T9397 2424-2426 CD denotes 45
T9398 2427-2430 NN denotes kDa
T9399 2431-2440 NN denotes cathepsin
T9400 2441-2442 NN denotes D
T9401 2473-2476 VBD denotes was
T9402 2447-2449 , denotes ,
T9403 2449-2461 VBG denotes representing
T9404 2462-2471 NN denotes precursor
T9405 2471-2473 , denotes ,
T9406 2477-2480 DT denotes the
T9407 2493-2497 NN denotes band
T9408 2481-2492 JJ denotes predominant
T9409 2498-2500 IN denotes in
T9410 2501-2505 JJ denotes wild
T9411 2506-2510 NN denotes type
T9412 2505-2506 HYPH denotes -
T9413 2511-2512 -LRB- denotes (
T9414 2512-2514 NN denotes wt
T9415 2514-2515 -RRB- denotes )
T9416 2516-2522 NN denotes tissue
T9417 2523-2526 CC denotes and
T9418 2527-2535 JJ denotes cellular
T9419 2536-2544 NNS denotes extracts
T9420 2544-2546 , denotes ,
T9421 2546-2550 IN denotes with
T9422 2551-2556 JJR denotes lower
T9423 2557-2563 NNS denotes levels
T9424 2564-2566 IN denotes of
T9425 2567-2573 JJ denotes mature
T9426 2574-2580 NN denotes enzyme
T9427 2581-2582 -LRB- denotes (
T9428 2600-2603 NN denotes kDa
T9429 2582-2588 JJ denotes single
T9430 2589-2594 NN denotes chain
T9431 2594-2596 , denotes ,
T9432 2596-2597 SYM denotes ~
T9433 2597-2599 CD denotes 43
T9434 2603-2605 , denotes ,
T9435 2605-2608 CC denotes and
T9436 2609-2614 JJ denotes heavy
T9437 2615-2620 NN denotes chain
T9438 2626-2629 NN denotes kDa
T9439 2620-2622 , denotes ,
T9440 2622-2623 SYM denotes ~
T9441 2623-2625 CD denotes 31
T9442 2629-2630 -RRB- denotes )
T9443 2630-2631 . denotes .
T9444 2631-2848 sentence denotes Conversely, homozygous Cln3Δex7/8 and CbCln3Δex7/8 mutant (m) extracts exhibited reduced levels of precursor and heavy chain of the double-chain form of the enzyme, with elevated levels of single-chain mature enzyme.
T9445 2632-2642 RB denotes Conversely
T9446 2703-2712 VBD denotes exhibited
T9447 2642-2644 , denotes ,
T9448 2644-2654 JJ denotes homozygous
T9449 2694-2702 NNS denotes extracts
T9450 2655-2663 NN denotes Cln3Δex7
T9451 2663-2664 HYPH denotes /
T9452 2664-2665 CD denotes 8
T9453 2666-2669 CC denotes and
T9454 2670-2680 NN denotes CbCln3Δex7
T9455 2680-2681 HYPH denotes /
T9456 2681-2682 CD denotes 8
T9457 2683-2689 NN denotes mutant
T9458 2690-2691 -LRB- denotes (
T9459 2691-2692 NN denotes m
T9460 2692-2693 -RRB- denotes )
T9461 2713-2720 VBN denotes reduced
T9462 2721-2727 NNS denotes levels
T9463 2728-2730 IN denotes of
T9464 2731-2740 NN denotes precursor
T9465 2741-2744 CC denotes and
T9466 2745-2750 JJ denotes heavy
T9467 2751-2756 NN denotes chain
T9468 2757-2759 IN denotes of
T9469 2760-2763 DT denotes the
T9470 2777-2781 NN denotes form
T9471 2764-2770 JJ denotes double
T9472 2771-2776 NN denotes chain
T9473 2770-2771 HYPH denotes -
T9474 2782-2784 IN denotes of
T9475 2785-2788 DT denotes the
T9476 2789-2795 NN denotes enzyme
T9477 2795-2797 , denotes ,
T9478 2797-2801 IN denotes with
T9479 2802-2810 JJ denotes elevated
T9480 2811-2817 NNS denotes levels
T9481 2818-2820 IN denotes of
T9482 2821-2827 JJ denotes single
T9483 2828-2833 NN denotes chain
T9484 2827-2828 HYPH denotes -
T9485 2841-2847 NN denotes enzyme
T9486 2834-2840 JJ denotes mature
T9487 2847-2848 . denotes .
T2791 1421-1425 JJ denotes wild
T2792 1426-1430 NN denotes type
T2793 1425-1426 HYPH denotes -
T2794 1431-1439 NNS denotes extracts
T2795 1439-1440 . denotes .
T2796 1440-1559 sentence denotes The cellular growth media did not contain altered levels of cathepsin D, indicating enzyme secretion was not affected.
T2797 1441-1444 DT denotes The
T2798 1461-1466 NNS denotes media
T2799 1445-1453 JJ denotes cellular
T2800 1454-1460 NN denotes growth
T2801 1475-1482 VB denotes contain
T2802 1467-1470 VBD denotes did
T2803 1471-1474 RB denotes not
T2804 1483-1490 VBN denotes altered
T2805 1491-1497 NNS denotes levels
T2806 1498-1500 IN denotes of
T2807 1501-1510 NN denotes cathepsin
T2808 1511-1512 NN denotes D
T2809 1512-1514 , denotes ,
T2810 1514-1524 VBG denotes indicating
T2811 1525-1531 NN denotes enzyme
T2812 1532-1541 NN denotes secretion
T2813 1550-1558 VBN denotes affected
T2814 1542-1545 VBD denotes was
T2815 1546-1549 RB denotes not
T2816 1558-1559 . denotes .
T2817 1559-1714 sentence denotes Heterozygous Cln3Δex7/8 mice and CbCln3Δex7/8 cells were indistinguishable from wild-type, as expected for a recessive disease phenotype (data not shown).
T2818 1560-1572 JJ denotes Heterozygous
T2819 1584-1588 NNS denotes mice
T2820 1573-1581 NN denotes Cln3Δex7
T2821 1581-1582 HYPH denotes /
T2822 1582-1583 CD denotes 8
T2823 1612-1616 VBD denotes were
T2824 1589-1592 CC denotes and
T2825 1593-1603 NN denotes CbCln3Δex7
T2826 1606-1611 NNS denotes cells
T2827 1603-1604 HYPH denotes /
T2828 1604-1605 CD denotes 8
T2829 1617-1634 JJ denotes indistinguishable
T2830 1635-1639 IN denotes from
T2831 1640-1644 JJ denotes wild
T2832 1645-1649 NN denotes type
T2833 1644-1645 HYPH denotes -
T2834 1649-1651 , denotes ,
T2835 1651-1653 IN denotes as
T2836 1654-1662 VBN denotes expected
T2837 1663-1666 IN denotes for
T2849 2849-2868 sentence denotes The impact of the a
T2850 2849-2852 DT denotes The
T2851 2853-2854 NN denotes i
T2852 2854-2855 JJ denotes m
T2853 2855-2856 NN denotes p
T2854 2856-2857 CC denotes a
T2855 2857-2858 JJ denotes c
T2856 2858-2859 NNS denotes t
T2857 2859-2860 , denotes
T2858 2860-2861 JJR denotes o
T2859 2861-2862 IN denotes f
T2860 2863-2864 JJ denotes t
T2861 2864-2865 NN denotes h
T2862 2865-2866 JJ denotes e
T2863 2867-2868 NN denotes a
T2864 2868-2880 sentence denotes ltered cathe
T2865 2868-2869 RB denotes l
T2866 2872-2874 VBD denotes ed
T2867 2870-2872 NNS denotes er
T2868 2869-2870 NN denotes t
T2869 2875-2876 VBN denotes c
T2870 2876-2877 CC denotes a
T2871 2877-2880 DT denotes the
T2872 2880-3023 sentence denotes psin D processing on enzymatic activity was next tested to determine if altered enzymatic activity accounts for inefficient subunit c turnover.
T2873 2880-2881 NN denotes p
T2874 2929-2935 VBN denotes tested
T2875 2887-2897 NN denotes processing
T2876 2881-2884 NN denotes sin
T2877 2885-2886 NN denotes D
T2878 2898-2900 IN denotes on
T2879 2901-2910 JJ denotes enzymatic
T2880 2911-2919 NN denotes activity
T2881 2920-2923 VBD denotes was
T2882 2924-2928 RB denotes next
T2883 2936-2938 TO denotes to
T2884 2939-2948 VB denotes determine
T2885 2949-2951 IN denotes if
T2886 2979-2987 VBZ denotes accounts
T2887 2952-2959 VBN denotes altered
T2888 2970-2978 NN denotes activity
R5964 T9402 T9395 punct ", ",band
R5965 T9403 T9395 acl representing,band
R5966 T9404 T9403 dobj precursor,representing
R5967 T9405 T9401 punct ", ",was
R5968 T9406 T9407 det the,band
R5969 T9407 T9401 attr band,was
R5970 T9408 T9407 amod predominant,band
R5971 T9409 T9407 prep in,band
R5834 T9260 T9261 amod wild,type
R5835 T9261 T9263 nmod type,cells
R5836 T9262 T9261 punct -,type
R5838 T9264 T9261 cc and,type
R5839 T9265 T9261 conj homozygous,type
R5840 T9266 T9263 nmod CbCln3Δex7,cells
R5841 T9267 T9266 punct /,CbCln3Δex7
R5862 T9290 T9273 acl recognizing,Immunostaining
R5863 T9291 T9292 amod unprocessed,forms
R5864 T9292 T9290 dobj forms,recognizing
R5865 T9293 T9291 cc and,unprocessed
R5866 T9294 T9291 conj processed,unprocessed
R5867 T9295 T9292 prep of,forms
R5868 T9296 T9297 compound cathepsin,D
R5869 T9297 T9298 compound D,protein
R5870 T9298 T9295 pobj protein,of
R5871 T9299 T9271 auxpass is,shown
R5872 T9300 T9271 punct .,shown
R5873 T9302 T9303 nmod CbCln3,cells
R5874 T9303 T9307 nsubj cells,exhibited
R5875 T9304 T9302 punct +,CbCln3
R5876 T9305 T9302 punct /,CbCln3
R5877 T9306 T9302 punct +,CbCln3
R5878 T9308 T9309 punct (,panel
R5879 T9309 T9303 parataxis panel,cells
R5880 T9310 T9309 amod left,panel
R5881 T9311 T9309 punct ),panel
R5882 T9312 T9313 det a,signal
R5883 T9313 T9307 dobj signal,exhibited
R5884 T9314 T9313 amod perinuclear,signal
R5885 T9315 T9314 cc and,perinuclear
R5886 T9316 T9314 conj cytoplasmic,perinuclear
R5887 T9317 T9313 amod punctate,signal
R5888 T9318 T9307 punct .,exhibited
R5889 T9320 T9321 compound Cathepsin,D
R5890 T9321 T9322 compound D,signal
R5891 T9322 T9323 nsubj signal,was
R5892 T9324 T9322 prep in,signal
R5893 T9325 T9326 amod homozygous,cells
R5894 T9326 T9324 pobj cells,in
R5895 T9327 T9326 nmod CbCln3Δex7,cells
R5896 T9328 T9327 punct /,CbCln3Δex7
R5897 T9329 T9327 nummod 8,CbCln3Δex7
R5898 T9330 T9331 punct (,panel
R5899 T9331 T9322 parataxis panel,signal
R5900 T9332 T9331 amod right,panel
R5901 T9333 T9331 punct ),panel
R5902 T9334 T9335 advmod more,often
R5903 T9335 T9323 advmod often,was
R5904 T9336 T9323 acomp perinuclear,was
R5905 T9337 T9323 punct ", ",was
R5906 T9338 T9323 prep with,was
R5907 T9339 T9340 advmod less,signal
R5908 T9340 T9338 pobj signal,with
R5909 T9341 T9342 amod cytoplasmic,punctate
R5910 T9342 T9340 compound punctate,signal
R5911 T9343 T9340 punct ", ",signal
R5912 T9344 T9340 prep compared,signal
R5913 T9345 T9344 prep to,compared
R5914 T9346 T9347 amod wild,type
R5915 T9347 T9349 nmod type,cells
R5916 T9348 T9347 punct -,type
R5917 T9349 T9345 pobj cells,to
R5918 T9350 T9349 nmod CbCln3,cells
R5919 T9351 T9350 punct +,CbCln3
R5920 T9352 T9350 punct /,CbCln3
R5921 T9353 T9350 punct +,CbCln3
R5922 T9354 T9323 punct .,was
R5923 T9356 T9357 nummod 40,magnification
R5924 T9358 T9356 punct ×,40
R5925 T9359 T9357 punct .,magnification
R5926 T9361 T9362 meta b,shown
R5927 T9363 T9361 punct .,b
R5928 T9364 T9365 compound α,D
R5929 T9365 T9368 npadvmod D,probed
R5930 T9366 T9365 punct -,D
R5931 T9367 T9365 compound Cathepsin,D
R5932 T9368 T9370 amod probed,immunoblots
R5933 T9369 T9368 punct -,probed
R5934 T9370 T9362 nsubjpass immunoblots,shown
R5935 T9371 T9370 prep of,immunoblots
R5936 T9372 T9373 amod total,tissue
R5938 T9374 T9375 amod wild,type
R5939 T9375 T9373 nmod type,tissue
R5940 T9376 T9375 punct -,type
R5959 T9396 T9397 punct ~,45
R5960 T9397 T9398 nummod 45,kDa
R5961 T9398 T9395 compound kDa,band
R5962 T9399 T9400 compound cathepsin,D
R5963 T9400 T9395 compound D,band
R5972 T9410 T9411 amod wild,type
R5973 T9411 T9409 pobj type,in
R5974 T9412 T9411 punct -,type
R5975 T9413 T9411 punct (,type
R5976 T9414 T9411 appos wt,type
R5977 T9415 T9411 punct ),type
R5978 T9416 T9411 appos tissue,type
R5979 T9417 T9416 cc and,tissue
R5980 T9418 T9419 amod cellular,extracts
R5981 T9419 T9416 conj extracts,tissue
R5982 T9420 T9407 punct ", ",band
R5983 T9421 T9407 prep with,band
R5984 T9422 T9423 amod lower,levels
R5985 T9423 T9421 pobj levels,with
R5986 T9424 T9423 prep of,levels
R5987 T9425 T9426 amod mature,enzyme
R5988 T9426 T9424 pobj enzyme,of
R5989 T9427 T9428 punct (,kDa
R5990 T9428 T9401 parataxis kDa,was
R5991 T9429 T9430 amod single,chain
R5992 T9430 T9428 dep chain,kDa
R5993 T9431 T9428 punct ", ",kDa
R5994 T9432 T9433 punct ~,43
R5995 T9433 T9428 nummod 43,kDa
R5996 T9434 T9428 punct ", ",kDa
R5997 T9435 T9428 cc and,kDa
R5998 T9436 T9437 amod heavy,chain
R5999 T9437 T9438 dep chain,kDa
R6000 T9438 T9428 conj kDa,kDa
R6001 T9439 T9438 punct ", ",kDa
R6002 T9440 T9441 punct ~,31
R6003 T9441 T9438 nummod 31,kDa
R6004 T9442 T9438 punct ),kDa
R6005 T9443 T9401 punct .,was
R6006 T9445 T9446 advmod Conversely,exhibited
R6007 T9447 T9446 punct ", ",exhibited
R6008 T9448 T9449 amod homozygous,extracts
R6009 T9449 T9446 nsubj extracts,exhibited
R6010 T9450 T9449 nmod Cln3Δex7,extracts
R6011 T9451 T9450 punct /,Cln3Δex7
R6012 T9452 T9450 nummod 8,Cln3Δex7
R6013 T9453 T9450 cc and,Cln3Δex7
R6014 T9454 T9450 conj CbCln3Δex7,Cln3Δex7
R6015 T9455 T9454 punct /,CbCln3Δex7
R6016 T9456 T9454 nummod 8,CbCln3Δex7
R6017 T9457 T9449 nmod mutant,extracts
R6018 T9458 T9457 punct (,mutant
R6019 T9459 T9457 appos m,mutant
R6020 T9460 T9449 punct ),extracts
R6021 T9461 T9462 amod reduced,levels
R6022 T9462 T9446 dobj levels,exhibited
R6023 T9463 T9462 prep of,levels
R6024 T9464 T9463 pobj precursor,of
R6025 T9465 T9464 cc and,precursor
R6026 T9466 T9467 amod heavy,chain
R6027 T9467 T9464 conj chain,precursor
R6028 T9468 T9464 prep of,precursor
R6029 T9469 T9470 det the,form
R6030 T9470 T9468 pobj form,of
R6031 T9471 T9472 amod double,chain
R6032 T9472 T9470 compound chain,form
R6033 T9473 T9472 punct -,chain
R6034 T9474 T9470 prep of,form
R6035 T9475 T9476 det the,enzyme
R6036 T9476 T9474 pobj enzyme,of
R6037 T9477 T9446 punct ", ",exhibited
R6038 T9478 T9446 prep with,exhibited
R6039 T9479 T9480 amod elevated,levels
R6040 T9480 T9478 pobj levels,with
R6041 T9481 T9480 prep of,levels
R6042 T9482 T9483 amod single,chain
R6043 T9483 T9485 nmod chain,enzyme
R6044 T9484 T9483 punct -,chain
R6045 T9485 T9481 pobj enzyme,of
R6046 T9486 T9485 amod mature,enzyme
R6047 T9487 T9446 punct .,exhibited
R1375 T2526 T2527 amod Homozygous,cells
R1376 T2527 T2531 nsubj cells,process
R1377 T2528 T2527 nmod CbCln3Δex7,cells
R1378 T2529 T2528 punct /,CbCln3Δex7
R1379 T2530 T2528 nummod 8,CbCln3Δex7
R1380 T2532 T2527 cc and,cells
R1381 T2533 T2534 nmod Cln3Δex7,mice
R1382 T2534 T2527 conj mice,cells
R1383 T2535 T2533 punct /,Cln3Δex7
R1384 T2536 T2533 nummod 8,Cln3Δex7
R1385 T2537 T2534 amod knock,mice
R1386 T2538 T2537 punct -,knock
R1387 T2539 T2537 prt in,knock
R1388 T2540 T2541 compound cathepsin,D
R1389 T2541 T2531 dobj D,process
R1390 T2542 T2531 advmod abnormally,process
R1391 T2544 T2545 nsubj We,investigated
R1392 T2546 T2545 advmod next,investigated
R1393 T2547 T2548 det the,basis
R1394 T2548 T2545 dobj basis,investigated
R1395 T2549 T2548 prep for,basis
R1396 T2550 T2551 compound subunit,c
R1397 T2551 T2552 compound c,accumulation
R1398 T2552 T2549 pobj accumulation,for
R1399 T2553 T2545 punct ", ",investigated
R1400 T2554 T2545 advcl testing,investigated
R1401 T2555 T2556 det the,hypothesis
R1402 T2556 T2554 dobj hypothesis,testing
R1403 T2557 T2558 mark that,is
R1404 T2558 T2556 acl is,hypothesis
R1405 T2559 T2560 compound cathepsin,D
R1406 T2560 T2558 nsubj D,is
R1407 T2561 T2558 acomp abnormal,is
R1408 T2562 T2563 mark since,is
R1409 T2563 T2558 advcl is,is
R1410 T2564 T2563 nsubj it,is
R1411 T2565 T2563 acomp required,is
R1412 T2566 T2565 prep for,required
R1413 T2567 T2568 compound ATP,degradation
R1414 T2568 T2566 pobj degradation,for
R1415 T2569 T2568 compound synthase,degradation
R1416 T2570 T2571 compound subunit,c
R1417 T2571 T2568 compound c,degradation
R1418 T2572 T2568 prep in,degradation
R1419 T2573 T2574 det the,lysosome
R1420 T2574 T2572 pobj lysosome,in
R1421 T2575 T2576 punct [,13
R1422 T2576 T2554 parataxis 13,testing
R1423 T2577 T2576 punct ],13
R1424 T2578 T2545 punct .,investigated
R1425 T2580 T2581 nsubj We,tested
R1426 T2582 T2581 advmod first,tested
R1427 T2583 T2584 compound cathepsin,D
R1428 T2584 T2581 dobj D,tested
R1429 T2585 T2584 appos transport,D
R1430 T2586 T2585 cc and,transport
R1431 T2587 T2585 conj processing,transport
R1432 T2588 T2581 prep in,tested
R1433 T2589 T2590 amod homozygous,cells
R1434 T2590 T2588 pobj cells,in
R1435 T2591 T2590 nmod CbCln3Δex7,cells
R1436 T2592 T2591 punct /,CbCln3Δex7
R1437 T2593 T2591 nummod 8,CbCln3Δex7
R1438 T2594 T2590 cc and,cells
R1439 T2595 T2596 nmod Cln3Δex7,mice
R1440 T2596 T2590 conj mice,cells
R1441 T2597 T2595 punct /,Cln3Δex7
R1442 T2598 T2595 nummod 8,Cln3Δex7
R1443 T2599 T2581 advcl using,tested
R1444 T2600 T2601 amod anti-cathepsin,D
R1445 T2601 T2602 amod D,antibody
R1446 T2602 T2599 dobj antibody,using
R1447 T2603 T2604 dep that,recognizes
R1448 T2604 T2602 relcl recognizes,antibody
R1449 T2605 T2606 amod unprocessed,isoforms
R1450 T2606 T2604 dobj isoforms,recognizes
R1451 T2607 T2605 cc and,unprocessed
R1452 T2608 T2605 conj processed,unprocessed
R1453 T2609 T2610 compound cathepsin,D
R1454 T2610 T2606 compound D,isoforms
R1455 T2611 T2581 punct .,tested
R1456 T2613 T2614 nsubj Immunostaining,revealed
R1457 T2615 T2613 prep of,Immunostaining
R1458 T2616 T2617 amod wild,type
R1459 T2617 T2619 nmod type,cells
R1460 T2618 T2617 punct -,type
R1461 T2619 T2615 pobj cells,of
R1462 T2620 T2617 cc and,type
R1463 T2621 T2617 conj homozygous,type
R1464 T2622 T2619 nmod CbCln3Δex7,cells
R1465 T2623 T2622 punct /,CbCln3Δex7
R1466 T2624 T2622 nummod 8,CbCln3Δex7
R1467 T2625 T2626 det a,distribution
R1468 T2626 T2614 dobj distribution,revealed
R1469 T2627 T2626 amod perinuclear,distribution
R1470 T2628 T2627 cc and,perinuclear
R1471 T2629 T2627 conj punctate,perinuclear
R1472 T2630 T2626 amod vesicular,distribution
R1473 T2631 T2632 compound cathepsin,D
R1474 T2632 T2626 compound D,distribution
R1475 T2633 T2614 punct ", ",revealed
R1476 T2634 T2614 advcl consistent,revealed
R1477 T2635 T2634 prep with,consistent
R1478 T2636 T2637 poss its,transport
R1479 T2637 T2635 pobj transport,with
R1480 T2638 T2637 cc and,transport
R1481 T2639 T2637 conj processing,transport
R1482 T2640 T2637 prep through,transport
R1483 T2641 T2642 det the,pathway
R1484 T2642 T2640 pobj pathway,through
R1485 T2643 T2642 amod secretory,pathway
R1486 T2644 T2637 cc and,transport
R1487 T2645 T2637 conj delivery,transport
R1488 T2646 T2645 prep to,delivery
R1489 T2647 T2648 det the,lysosome
R1490 T2648 T2646 pobj lysosome,to
R1491 T2649 T2650 punct (,5a
R1492 T2650 T2614 parataxis 5a,revealed
R1493 T2651 T2650 compound Fig.,5a
R1494 T2652 T2650 punct ),5a
R1495 T2653 T2614 punct .,revealed
R1496 T2655 T2656 advmod However,was
R1497 T2657 T2656 punct ", ",was
R1498 T2658 T2656 prep in,was
R1499 T2659 T2660 amod homozygous,cells
R1500 T2660 T2658 pobj cells,in
R1501 T2661 T2660 nmod CbCln3Δex7,cells
R1502 T2662 T2661 punct /,CbCln3Δex7
R1503 T2663 T2661 nummod 8,CbCln3Δex7
R1504 T2664 T2656 punct ", ",was
R1505 T2665 T2666 compound cathepsin,D
R1506 T2666 T2667 compound D,distribution
R1507 T2667 T2656 nsubj distribution,was
R1508 T2668 T2669 advmod less,vesicular
R1509 T2669 T2656 acomp vesicular,was
R1510 T2670 T2669 cc and,vesicular
R1511 T2671 T2672 advmod more,clustered
R1512 T2672 T2669 conj clustered,vesicular
R1513 T2673 T2672 amod perinuclear,clustered
R1514 T2674 T2672 punct -,clustered
R1515 T2675 T2669 prep than,vesicular
R1516 T2676 T2675 prep in,than
R1517 T2677 T2678 amod wild,type
R1518 T2678 T2680 compound type,cells
R1519 T2679 T2678 punct -,type
R1520 T2680 T2676 pobj cells,in
R1521 T2681 T2656 punct .,was
R1522 T2683 T2684 nsubj Immunoblots,showed
R1523 T2685 T2683 prep of,Immunoblots
R1524 T2686 T2687 amod homozygous,extracts
R1525 T2687 T2685 pobj extracts,of
R1526 T2688 T2689 nmod CbCln3Δex7,cell
R1527 T2689 T2687 nmod cell,extracts
R1528 T2690 T2688 punct /,CbCln3Δex7
R1529 T2691 T2688 nummod 8,CbCln3Δex7
R1530 T2692 T2689 cc and,cell
R1531 T2693 T2694 nmod Cln3Δex7,tissue
R1532 T2694 T2689 conj tissue,cell
R1533 T2695 T2693 punct /,Cln3Δex7
R1534 T2696 T2693 nummod 8,Cln3Δex7
R1535 T2697 T2684 advmod also,showed
R1536 T2698 T2699 amod altered,levels
R1537 T2699 T2684 dobj levels,showed
R1538 T2700 T2699 amod relative,levels
R1539 T2701 T2699 prep of,levels
R1540 T2702 T2703 compound cathepsin,D
R1541 T2703 T2704 compound D,isoforms
R1542 T2704 T2701 pobj isoforms,of
R1543 T2705 T2706 punct (,5b
R1544 T2706 T2684 parataxis 5b,showed
R1545 T2707 T2706 compound Fig.,5b
R1546 T2708 T2706 punct ),5b
R1547 T2709 T2684 punct .,showed
R1548 T2711 T2712 compound Cathepsin,D
R1549 T2712 T2713 compound D,isoforms
R1550 T2713 T2714 nsubj isoforms,represent
R1551 T2715 T2713 punct ", ",isoforms
R1552 T2716 T2713 acl identified,isoforms
R1553 T2717 T2716 agent by,identified
R1554 T2718 T2719 amod relative,weights
R1555 T2719 T2717 pobj weights,by
R1556 T2720 T2719 amod molecular,weights
R1557 T2721 T2714 punct ", ",represent
R1558 T2722 T2723 det the,precursor
R1559 T2723 T2714 dobj precursor,represent
R1560 T2724 T2725 punct ~,45
R1561 T2725 T2726 nummod 45,kDa
R1562 T2726 T2723 compound kDa,precursor
R1563 T2727 T2723 punct ", ",precursor
R1564 T2728 T2729 det the,form
R1565 T2729 T2723 conj form,precursor
R1566 T2730 T2731 punct ~,43
R1567 T2731 T2732 nummod 43,kDa
R1568 T2732 T2729 nmod kDa,form
R1569 T2733 T2729 amod intermediate,form
R1570 T2734 T2735 amod single,chain
R1571 T2735 T2729 compound chain,form
R1572 T2736 T2729 prep of,form
R1573 T2737 T2738 det the,enzyme
R1574 T2738 T2736 pobj enzyme,of
R1575 T2739 T2729 punct ", ",form
R1576 T2740 T2729 cc and,form
R1577 T2741 T2742 det the,chain
R1578 T2742 T2729 conj chain,form
R1579 T2743 T2744 nummod 31,kDa
R1580 T2744 T2742 nmod kDa,chain
R1581 T2745 T2742 amod heavy,chain
R1582 T2746 T2742 prep of,chain
R1583 T2747 T2748 det the,form
R1584 T2748 T2746 pobj form,of
R1585 T2749 T2750 amod double,chain
R1586 T2750 T2748 compound chain,form
R1587 T2751 T2750 punct -,chain
R1588 T2752 T2748 prep of,form
R1589 T2753 T2754 det the,enzyme
R1590 T2754 T2752 pobj enzyme,of
R1591 T2755 T2754 amod mature,enzyme
R1592 T2756 T2757 punct [,14
R1593 T2757 T2714 parataxis 14,represent
R1594 T2758 T2757 punct ],14
R1595 T2759 T2714 punct .,represent
R1596 T2761 T2762 prep In,reduced
R1597 T2763 T2764 amod homozygous,extracts
R1598 T2764 T2761 pobj extracts,In
R1599 T2765 T2766 nmod CbCln3Δex7,cell
R1600 T2766 T2764 nmod cell,extracts
R1601 T2767 T2765 punct /,CbCln3Δex7
R1602 T2768 T2765 nummod 8,CbCln3Δex7
R1603 T2769 T2766 cc and,cell
R1604 T2770 T2771 nmod Cln3Δex7,tissue
R1605 T2771 T2766 conj tissue,cell
R1606 T2772 T2770 punct /,Cln3Δex7
R1607 T2773 T2770 nummod 8,Cln3Δex7
R1608 T2774 T2762 punct ", ",reduced
R1609 T2775 T2776 det the,precursor
R1610 T2776 T2762 nsubjpass precursor,reduced
R1611 T2777 T2776 cc and,precursor
R1612 T2778 T2779 amod heavy,chains
R1613 T2779 T2776 conj chains,precursor
R1614 T2780 T2762 auxpass were,reduced
R1615 T2781 T2762 punct ", ",reduced
R1616 T2782 T2762 cc and,reduced
R1617 T2783 T2784 det the,chain
R1618 T2784 T2786 nsubj chain,was
R1619 T2785 T2784 amod single,chain
R1620 T2786 T2762 conj was,reduced
R1621 T2787 T2788 advmod slightly,elevated
R1622 T2788 T2786 acomp elevated,was
R1623 T2789 T2786 prep compared,was
R1624 T2790 T2789 prep to,compared
R1625 T2791 T2792 amod wild,type
R1626 T2792 T2794 compound type,extracts
R1627 T2793 T2792 punct -,type
R1628 T2794 T2790 pobj extracts,to
R1629 T2795 T2786 punct .,was
R1630 T2797 T2798 det The,media
R1631 T2798 T2801 nsubj media,contain
R1632 T2799 T2800 amod cellular,growth
R1633 T2800 T2798 compound growth,media
R1634 T2802 T2801 aux did,contain
R1635 T2803 T2801 neg not,contain
R1636 T2804 T2805 amod altered,levels
R1637 T2805 T2801 dobj levels,contain
R1638 T2806 T2805 prep of,levels
R1639 T2807 T2808 compound cathepsin,D
R1640 T2808 T2806 pobj D,of
R1641 T2809 T2801 punct ", ",contain
R1642 T2810 T2801 advcl indicating,contain
R1700 T2892 T2890 pobj turnover,for
R1701 T2893 T2894 compound subunit,c
R1702 T2894 T2892 compound c,turnover
R1703 T2895 T2874 punct .,tested
R1704 T2897 T2898 prep In,altered
R1705 T2899 T2900 det a,assay
R1706 T2900 T2897 pobj assay,In
R1707 T2901 T2900 amod fluorogenic,assay
R1708 T2902 T2903 advmod in,vitro
R1709 T2903 T2900 amod vitro,assay
R1710 T2904 T2898 punct ", ",altered
R1711 T2905 T2906 compound cathepsin,D
R1712 T2906 T2907 compound D,activity
R1713 T2907 T2898 nsubjpass activity,altered
R1714 T2908 T2907 prep in,activity
R1715 T2909 T2910 amod total,extracts
R1716 T2910 T2908 pobj extracts,in
R1717 T2911 T2910 amod cellular,extracts
R1718 T2912 T2898 auxpass was,altered
R1719 T2913 T2898 neg not,altered
R1720 T2914 T2898 advmod significantly,altered
R1721 T2915 T2898 prep in,altered
R1722 T2916 T2917 amod homozygous,cells
R1723 T2917 T2915 pobj cells,in
R1724 T2918 T2917 nmod CbCln3Δex7,cells
R1725 T2919 T2918 punct /,CbCln3Δex7
R1726 T2920 T2918 nummod 8,CbCln3Δex7
R1727 T2921 T2922 punct (,RFU
R1728 T2922 T2917 parataxis RFU,cells
R1729 T2923 T2924 quantmod 376,89
R1730 T2924 T2922 nummod 89,RFU
R1731 T2925 T2924 punct ±,89
R1732 T2926 T2927 punct /,protein
R1733 T2927 T2922 prep protein,RFU
R1734 T2928 T2927 nmod μg,protein
R1735 T2929 T2927 amod total,protein
R1736 T2930 T2922 punct ),RFU
R1737 T2931 T2917 punct ", ",cells
R1738 T2932 T2917 cc versus,cells
R1739 T2933 T2934 amod wild,type
R1740 T2934 T2936 compound type,cells
R1741 T2935 T2934 punct -,type
R1742 T2936 T2917 conj cells,cells
R1743 T2937 T2938 punct (,RFU
R1744 T2938 T2936 parataxis RFU,cells
R1745 T2939 T2940 quantmod 324,58
R1746 T2940 T2938 nummod 58,RFU
R1747 T2941 T2940 quantmod ±,58
R1748 T2942 T2943 punct /,protein
R1749 T2943 T2938 prep protein,RFU
R1750 T2944 T2943 nmod μg,protein
R1751 T2945 T2943 amod total,protein
R1752 T2946 T2938 punct ),RFU
R1753 T2947 T2898 punct ", ",altered
R1754 T2948 T2949 mark although,observed
R1755 T2949 T2898 advcl observed,altered
R1756 T2950 T2951 det a,trend
R1757 T2951 T2949 nsubjpass trend,observed
R1758 T2952 T2951 amod consistent,trend
R1759 T2953 T2951 prep towards,trend
R1760 T2954 T2955 amod increased,activity
R1761 T2955 T2953 pobj activity,towards
R1762 T2956 T2955 amod enzymatic,activity
R1763 T2957 T2955 prep in,activity
R1764 T2958 T2959 compound mutant,cells
R1765 T2959 T2957 pobj cells,in
R1766 T2960 T2949 auxpass was,observed
R1767 T2961 T2898 punct .,altered
R1768 T2963 T2964 advmod Thus,disrupted
R1769 T2965 T2964 punct ", ",disrupted
R1770 T2966 T2967 compound cathepsin,D
R1771 T2967 T2964 nsubjpass D,disrupted
R1772 T2968 T2967 appos transport,D
R1773 T2969 T2968 cc and,transport
R1774 T2970 T2968 conj processing,transport
R1775 T2971 T2964 auxpass are,disrupted
R1776 T2972 T2964 prep in,disrupted
R1777 T2973 T2974 amod homozygous,cells
R1778 T2974 T2972 pobj cells,in
R1779 T2975 T2974 nmod CbCln3Δex7,cells
R1780 T2976 T2975 punct /,CbCln3Δex7
R1781 T2977 T2975 nummod 8,CbCln3Δex7
R1782 T2978 T2964 prep in,disrupted
R1783 T2979 T2980 det a,manner
R1784 T2980 T2978 pobj manner,in
R1785 T2981 T2980 amod such,manner
R1786 T2982 T2983 mark that,appears
R1787 T2983 T2981 ccomp appears,such
R1788 T2984 T2985 amod enzymatic,activity
R1789 T2985 T2983 nsubj activity,appears
R1790 T2986 T2987 aux to,be
R1791 T2987 T2983 xcomp be,appears
R1792 T2988 T2989 advmod relatively,unaffected
R1793 T2989 T2987 acomp unaffected,be
R1794 T2990 T2964 punct .,disrupted
R5844 T9272 T9270 punct .,a
R1687 T2879 T2880 amod enzymatic,activity
R1688 T2880 T2878 pobj activity,on
R1689 T2881 T2874 auxpass was,tested
R1690 T2882 T2874 advmod next,tested
R1691 T2883 T2884 aux to,determine
R1692 T2884 T2874 advcl determine,tested
R1693 T2885 T2886 mark if,accounts
R1694 T2886 T2884 ccomp accounts,determine
R1695 T2887 T2888 amod altered,activity
R1696 T2888 T2886 nsubj activity,accounts
R1697 T2889 T2888 amod enzymatic,activity
R1698 T2890 T2886 prep for,accounts
R1699 T2891 T2892 amod inefficient,turnover
R5829 T9254 T9255 compound Cathepsin,D
R5830 T9256 T9255 appos localization,D
R5831 T9257 T9256 cc and,localization
R5832 T9258 T9256 conj processing,localization
R5833 T9259 T9255 prep in,D
R5837 T9263 T9259 pobj cells,in
R5842 T9268 T9266 nummod 8,CbCln3Δex7
R5843 T9270 T9271 meta a,shown
R5845 T9273 T9271 nsubjpass Immunostaining,shown
R5846 T9274 T9273 prep of,Immunostaining
R5847 T9275 T9276 amod wild,type
R5848 T9276 T9278 nmod type,cells
R5849 T9277 T9276 punct -,type
R5850 T9278 T9274 pobj cells,of
R5851 T9279 T9276 cc and,type
R5852 T9280 T9276 conj homozygous,type
R5853 T9281 T9278 nmod CbCln3Δex7,cells
R5854 T9282 T9281 punct /,CbCln3Δex7
R5855 T9283 T9281 nummod 8,CbCln3Δex7
R5856 T9284 T9278 compound precursor,cells
R5857 T9285 T9273 prep with,Immunostaining
R5858 T9286 T9287 amod anti-cathepsin,D
R5859 T9287 T9288 amod D,antibody
R5860 T9288 T9285 pobj antibody,with
R5861 T9289 T9273 punct ", ",Immunostaining
R5937 T9373 T9371 pobj tissue,of
R5941 T9377 T9375 cc versus,type
R5942 T9378 T9379 amod homozygous,Cln3Δex7
R5943 T9379 T9380 npadvmod Cln3Δex7,knock
R5944 T9380 T9375 conj knock,type
R5945 T9381 T9379 punct /,Cln3Δex7
R5946 T9382 T9379 nummod 8,Cln3Δex7
R5947 T9383 T9380 punct -,knock
R5948 T9384 T9380 prt in,knock
R5949 T9385 T9373 cc or,tissue
R5950 T9386 T9387 nmod CbCln3Δex7,extracts
R5951 T9387 T9373 conj extracts,tissue
R5952 T9388 T9386 punct /,CbCln3Δex7
R5953 T9389 T9386 nummod 8,CbCln3Δex7
R5954 T9390 T9387 amod cellular,extracts
R5955 T9391 T9362 auxpass are,shown
R5956 T9392 T9362 punct .,shown
R5957 T9394 T9395 det The,band
R5958 T9395 T9401 nsubj band,was
R1643 T2811 T2812 compound enzyme,secretion
R1644 T2812 T2813 nsubjpass secretion,affected
R1645 T2813 T2810 advcl affected,indicating
R1646 T2814 T2813 auxpass was,affected
R1647 T2815 T2813 neg not,affected
R1648 T2816 T2801 punct .,contain
R1649 T2818 T2819 amod Heterozygous,mice
R1650 T2819 T2823 nsubj mice,were
R1651 T2820 T2819 nmod Cln3Δex7,mice
R1652 T2821 T2820 punct /,Cln3Δex7
R1653 T2822 T2820 nummod 8,Cln3Δex7
R1654 T2824 T2819 cc and,mice
R1655 T2825 T2826 nmod CbCln3Δex7,cells
R1656 T2826 T2819 conj cells,mice
R1657 T2827 T2825 punct /,CbCln3Δex7
R1658 T2828 T2825 nummod 8,CbCln3Δex7
R1659 T2829 T2823 acomp indistinguishable,were
R1660 T2830 T2829 prep from,indistinguishable
R1661 T2831 T2832 amod wild,type
R1662 T2832 T2830 pobj type,from
R1663 T2833 T2832 punct -,type
R1664 T2834 T2823 punct ", ",were
R1665 T2835 T2836 mark as,expected
R1666 T2836 T2823 advcl expected,were
R1667 T2837 T2836 prep for,expected
R1668 T2838 T2839 det a,phenotype
R1669 T2839 T2837 pobj phenotype,for
R1670 T2840 T2839 amod recessive,phenotype
R1671 T2841 T2839 compound disease,phenotype
R1672 T2842 T2843 punct (,shown
R1673 T2843 T2836 parataxis shown,expected
R1674 T2844 T2843 nsubj data,shown
R1675 T2845 T2843 neg not,shown
R1676 T2846 T2843 punct ),shown
R1677 T2847 T2823 punct .,were
R1678 T2855 T2856 amod c,t
R1679 T2862 T2863 amod e,a
R1680 T2865 T2866 advmod l,ed
R1681 T2867 T2866 nsubj er,ed
R1682 T2868 T2867 nmod t,er
R1683 T2873 T2874 nsubjpass p,tested
R1684 T2876 T2877 compound sin,D
R1685 T2877 T2875 compound D,processing
R1686 T2878 T2873 prep on,p

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2420 11-13 UBERON:0002037 denotes Cb
T2421 13-17 PR_EXT:000005591 denotes Cln3
T2422 24-29 CL_GO_EXT:cell denotes cells
T2423 34-38 PR_EXT:000005591 denotes Cln3
T2424 54-58 NCBITaxon:10088 denotes mice
T2425 59-66 SO_EXT:sequence_alteration_process denotes process
T2426 67-78 PR_EXT:000006025 denotes cathepsin D
T2427 125-134 PR_EXT:000022190 denotes subunit c
T2428 177-188 PR_EXT:000006025 denotes cathepsin D
T2429 226-229 CHEBI_EXT:ATP denotes ATP
T2430 226-248 PR_EXT:000022190 denotes ATP synthase subunit c
T2431 268-276 GO:0005764 denotes lysosome
T2432 299-310 PR_EXT:000006025 denotes cathepsin D
T2433 311-320 GO_EXT:biological_routing_or_transport denotes transport
T2434 325-335 SO_EXT:sequence_alteration_process denotes processing
T2435 350-352 UBERON:0002037 denotes Cb
T2436 352-356 PR_EXT:000005591 denotes Cln3
T2437 363-368 CL_GO_EXT:cell denotes cells
T2438 373-377 PR_EXT:000005591 denotes Cln3
T2439 384-388 NCBITaxon:10088 denotes mice
T2440 400-411 PR_EXT:000006025 denotes cathepsin D
T2441 412-420 GO:0042571 denotes antibody
T2442 439-448 SO_EXT:sequence_alteration_process denotes processed
T2443 453-462 SO_EXT:sequence_alteration_process denotes processed
T2477 1170-1176 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T2478 1212-1224 SO:0000985 denotes double-chain
T2479 1244-1250 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T2480 1271-1273 UBERON:0002037 denotes Cb
T2481 1273-1277 PR_EXT:000005591 denotes Cln3
T2482 1284-1288 CL_GO_EXT:cell denotes cell
T2483 1293-1297 PR_EXT:000005591 denotes Cln3
T2484 1304-1310 UBERON:0000479 denotes tissue
T2485 1421-1430 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2486 1445-1453 CL_GO_EXT:cell denotes cellular
T2487 1454-1460 GO_EXT:biological_growth_entity_or_process denotes growth
T2488 1501-1512 PR_EXT:000006025 denotes cathepsin D
T2489 1525-1531 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T2490 1532-1541 GO_EXT:secretion_entity_or_process denotes secretion
T2491 1573-1577 PR_EXT:000005591 denotes Cln3
T2492 1584-1588 NCBITaxon:10088 denotes mice
T2493 1593-1595 UBERON:0002037 denotes Cb
T2494 1595-1599 PR_EXT:000005591 denotes Cln3
T2495 1606-1611 CL_GO_EXT:cell denotes cells
T2496 1640-1649 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2497 2853-2854 PR_EXT:000006025 denotes i
T2498 2855-2856 SO_EXT:wild_type_entity_or_quality denotes p
T2499 2857-2858 CL_GO_EXT:cell denotes c
T2500 2869-2870 SO_EXT:sequence_altered_entity_or_alteration_process denotes t
T2501 2881-2886 PR_EXT:000006025 denotes sin D
T2502 2887-2897 SO_EXT:sequence_alteration_process denotes processing
T2503 2901-2910 CHEBI_GO_SO_EXT:enzyme denotes enzymatic
T2504 2960-2969 CHEBI_GO_SO_EXT:enzyme denotes enzymatic
T2505 3004-3013 PR_EXT:000022190 denotes subunit c
T2506 3029-3040 CHEBI_EXT:76219 denotes fluorogenic
T2507 3057-3068 PR_EXT:000006025 denotes cathepsin D
T2508 3087-3095 CL_GO_EXT:cell denotes cellular
T2509 3149-3151 UBERON:0002037 denotes Cb
T2510 3151-3155 PR_EXT:000005591 denotes Cln3
T2511 3162-3167 CL_GO_EXT:cell denotes cells
T2512 3191-3198 CHEBI_PR_EXT:protein denotes protein
T2513 3208-3217 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2514 3218-3223 CL_GO_EXT:cell denotes cells
T2515 3247-3254 CHEBI_PR_EXT:protein denotes protein
T2516 3303-3312 CHEBI_GO_SO_EXT:enzyme denotes enzymatic
T2517 3325-3331 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T2518 3332-3337 CL_GO_EXT:cell denotes cells
T2519 3358-3369 PR_EXT:000006025 denotes cathepsin D
T2520 3370-3379 GO_EXT:biological_routing_or_transport denotes transport
T2521 3384-3394 SO_EXT:sequence_alteration_process denotes processing
T2522 3423-3425 UBERON:0002037 denotes Cb
T2523 3425-3429 PR_EXT:000005591 denotes Cln3
T2524 3436-3441 CL_GO_EXT:cell denotes cells
T2525 3464-3473 CHEBI_GO_SO_EXT:enzyme denotes enzymatic
T9196 1725-1736 PR_EXT:000006025 denotes Cathepsin D
T9197 1737-1749 GO_PATO_EXT:biological_localization_process_or_quality denotes localization
T9198 1754-1764 SO_EXT:sequence_alteration_process denotes processing
T9199 1768-1777 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9200 1793-1795 UBERON:0002037 denotes Cb
T9201 1795-1799 PR_EXT:000005591 denotes Cln3
T9202 1806-1811 CL_GO_EXT:cell denotes cells
T9203 1833-1842 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9204 1858-1860 UBERON:0002037 denotes Cb
T9205 1860-1864 PR_EXT:000005591 denotes Cln3
T9206 1881-1886 CL_GO_EXT:cell denotes cells
T9207 1897-1908 PR_EXT:000006025 denotes cathepsin D
T9208 1909-1917 GO:0042571 denotes antibody
T9209 1933-1942 SO_EXT:sequence_alteration_process denotes processed
T9210 1947-1956 SO_EXT:sequence_alteration_process denotes processed
T9211 1966-1977 PR_EXT:000006025 denotes cathepsin D
T9212 1978-1985 CHEBI_PR_EXT:protein denotes protein
T9213 1996-1998 UBERON:0002037 denotes Cb
T9214 1998-2002 PR_EXT:000005591 denotes Cln3
T9215 2002-2003 SO_EXT:normal_or_wild_type_or_present denotes +
T9216 2004-2005 SO_EXT:normal_or_wild_type_or_present denotes +
T9217 2006-2011 CL_GO_EXT:cell denotes cells
T9218 2041-2048 GO:0005634 denotes nuclear
T9219 2053-2064 GO:0005737 denotes cytoplasmic
T9220 2082-2093 PR_EXT:000006025 denotes Cathepsin D
T9221 2115-2117 UBERON:0002037 denotes Cb
T9222 2117-2121 PR_EXT:000005591 denotes Cln3
T9223 2128-2133 CL_GO_EXT:cell denotes cells
T9224 2167-2174 GO:0005634 denotes nuclear
T9225 2186-2197 GO:0005737 denotes cytoplasmic
T9226 2227-2236 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9227 2237-2239 UBERON:0002037 denotes Cb
T9228 2239-2243 PR_EXT:000005591 denotes Cln3
T9229 2243-2244 SO_EXT:normal_or_wild_type_or_present denotes +
T9230 2245-2246 SO_EXT:normal_or_wild_type_or_present denotes +
T9231 2247-2252 CL_GO_EXT:cell denotes cells
T9232 2279-2290 PR_EXT:000006025 denotes Cathepsin D
T9233 2319-2328 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9234 2347-2351 PR_EXT:000005591 denotes Cln3
T9235 2367-2373 UBERON:0000479 denotes tissue
T9236 2377-2379 UBERON:0002037 denotes Cb
T9237 2379-2383 PR_EXT:000005591 denotes Cln3
T9238 2390-2398 CL_GO_EXT:cell denotes cellular
T9239 2431-2442 PR_EXT:000006025 denotes cathepsin D
T9240 2501-2510 SO_EXT:wild_type_entity_or_quality denotes wild-type
T9241 2512-2514 SO_EXT:wild_type_entity_or_quality denotes wt
T9242 2516-2522 UBERON:0000479 denotes tissue
T9243 2527-2535 CL_GO_EXT:cell denotes cellular
T9244 2574-2580 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T9245 2655-2659 PR_EXT:000005591 denotes Cln3
T9246 2670-2672 UBERON:0002037 denotes Cb
T9247 2672-2676 PR_EXT:000005591 denotes Cln3
T9248 2683-2689 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T9249 2691-2692 SO_EXT:sequence_altered_entity_or_alteration_process denotes m
T9250 2764-2776 SO:0000985 denotes double-chain
T9251 2789-2795 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T9252 2821-2833 SO:0000984 denotes single-chain
T9253 2841-2847 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T2444 463-474 PR_EXT:000006025 denotes cathepsin D
T2445 475-483 SO_EXT:0001060 denotes isoforms
T2446 503-512 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2447 528-530 UBERON:0002037 denotes Cb
T2448 530-534 PR_EXT:000005591 denotes Cln3
T2449 541-546 CL_GO_EXT:cell denotes cells
T2450 562-569 GO:0005634 denotes nuclear
T2451 583-592 GO:0031982 denotes vesicular
T2452 593-604 PR_EXT:000006025 denotes cathepsin D
T2453 639-648 GO_EXT:biological_routing_or_transport denotes transport
T2454 653-663 SO_EXT:sequence_alteration_process denotes processing
T2455 676-693 GO_EXT:secretory_pathway denotes secretory pathway
T2456 698-706 GO_EXT:biological_routing_or_transport denotes delivery
T2457 714-722 GO:0005764 denotes lysosome
T2458 757-759 UBERON:0002037 denotes Cb
T2459 759-763 PR_EXT:000005591 denotes Cln3
T2460 770-775 CL_GO_EXT:cell denotes cells
T2461 777-788 PR_EXT:000006025 denotes cathepsin D
T2462 811-820 GO:0031982 denotes vesicular
T2463 834-841 GO:0005634 denotes nuclear
T2464 860-869 SO_EXT:wild_type_entity_or_quality denotes wild-type
T2465 870-875 CL_GO_EXT:cell denotes cells
T2466 903-905 UBERON:0002037 denotes Cb
T2467 905-909 PR_EXT:000005591 denotes Cln3
T2468 916-920 CL_GO_EXT:cell denotes cell
T2469 925-929 PR_EXT:000005591 denotes Cln3
T2470 936-942 UBERON:0000479 denotes tissue
T2471 991-1002 PR_EXT:000006025 denotes cathepsin D
T2472 1003-1011 SO_EXT:0001060 denotes isoforms
T2473 1023-1034 PR_EXT:000006025 denotes Cathepsin D
T2474 1035-1043 SO_EXT:0001060 denotes isoforms
T2475 1068-1077 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T2476 1145-1157 SO:0000984 denotes single chain

2_test

Id Subject Object Predicate Lexical cue
15588329-12440525-12950144 278-280 12440525 denotes 13
15588329-12350228-12950145 1252-1254 12350228 denotes 14