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PMC:539061 / 8408-15642 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2400 0-5 PR:000015308 denotes Snail
T2401 27-36 GO:0010467 denotes Expressed
T2402 56-60 UBERON:0001037 denotes Hair
T2403 83-96 GO:0009653 denotes Morphogenesis
T2404 106-111 PR:000015308 denotes Snail
T2405 163-167 GO:0001837 denotes EMTs
T2406 284-307 GO:0005911 denotes intercellular junctions
T2407 360-365 PR:000015308 denotes Snail
T2408 428-438 UBERON:0000483 denotes epithelial
T2409 470-483 UBERON:0002073 denotes hair follicle
T2410 550-555 PR:000015308 denotes Snail
T2411 577-582 PR:000009751 denotes LEF-1
T2412 583-592 PR:000002198 denotes β-catenin
T2413 612-622 PR:000001447 denotes E-cadherin
T2414 623-633 GO:0010467 denotes expression
T2415 637-650 CL:0000312 denotes keratinocytes
T2416 701-706 PR:000009751 denotes LEF-1
T2417 707-716 PR:000002198 denotes β-catenin
T2418 720-733 UBERON:0002073 denotes hair follicle
T2419 720-747 GO:0031069 denotes hair follicle morphogenesis
T2420 788-793 PR:000015308 denotes Snail
T2421 794-798 PR:000015309 denotes Slug
T2422 887-892 PR:000015308 denotes Snail
T2423 898-908 GO:0010467 denotes expression
T2424 933-946 GO:0009790 denotes embryogenesis
T2425 961-975 UBERON:0002073 denotes hair follicles
T2426 1038-1043 PR:000015308 denotes Snail
T2427 1052-1061 GO:0010467 denotes expressed
T2428 1107-1120 GO:0097617 denotes hybridization
T2429 1154-1159 PR:000015308 denotes Snail
T2430 1160-1182 SO:0000205 denotes 3′ untranslated region
T2431 1160-1162 _FRAGMENT denotes 3′
T2432 1184-1187 SO:0000205 denotes UTR
T2433 1165-1175 GO:0006412 denotes translated
T2434 1190-1199 UBERON:0000922 denotes Embryonic
T2435 1266-1279 GO:0009653 denotes morphogenesis
T2436 1326-1331 PR:000015308 denotes Snail
T2437 1332-1342 GO:0010467 denotes expression
T2438 1411-1424 GO:0097617 denotes hybridization
T2439 1449-1459 UBERON:0000483 denotes epithelium
T2440 1471-1475 UBERON:0001037 denotes hair
T2441 1609-1622 GO:0097617 denotes hybridization
T2442 1660-1665 PR:000015308 denotes Snail
T2443 1671-1681 GO:0010467 denotes expression
T2444 1731-1741 GO:0097617 denotes hybridized
T2445 1805-1818 GO:0009653 denotes morphogenesis
T2446 1843-1854 GO:0097617 denotes Hybridizing
T2447 1855-1859 UBERON:0001037 denotes hair
T2448 1911-1922 GO:0097617 denotes hybridizing
T2449 4397-4402 PR:000015308 denotes Snail
T2450 4408-4418 GO:0010467 denotes expression
T2451 4470-4478 GO:0042571 denotes antibody
T2452 4567-4574 SO:0000417 denotes domains
T2453 4616-4624 GO:0042571 denotes antibody
T2454 4674-4687 CL:0000312 denotes keratinocytes
T2455 4739-4752 CL:0000312 denotes keratinocytes
T2456 4765-4775 GO:0010467 denotes expressing
T2457 4804-4809 PR:000015308 denotes Snail
T2458 4835-4843 GO:0042571 denotes antibody
T2459 4907-4912 PR:000015308 denotes Snail
T2460 4952-4961 UBERON:0000922 denotes embryonic
T2461 4962-4967 NCBITaxon:10088 denotes mouse
T2462 5036-5049 UBERON:0002073 denotes hair follicle
T2463 5036-5063 GO:0031069 denotes hair follicle morphogenesis
T2464 5107-5111 UBERON:0010164 denotes hair
T2465 5119-5124 NCBITaxon:10088 denotes mouse
T2466 5231-5236 PR:000015308 denotes Snail
T2467 5261-5270 UBERON:0007376 denotes epidermis
T2468 5351-5364 _FRAGMENT denotes commitment of
T2469 5377-5382 _FRAGMENT denotes cells
T2470 5409-5411 _FRAGMENT denotes to
T2471 5419-5428 GO:0045165 denotes cell fate
T2472 5377-5385 _FRAGMENT denotes cells of
T2473 5400-5408 CL:0000221 denotes ectoderm
T2474 5390-5408 UBERON:0000924 denotes embryonic ectoderm
T2475 5414-5418 UBERON:0001037 denotes hair
T2476 5414-5423 CL:0002559 denotes hair cell
T2477 5470-5483 GO:0097617 denotes hybridization
T2478 5498-5503 PR:000015308 denotes Snail
T2479 5504-5512 GO:0042571 denotes antibody
T2480 5526-5530 _FRAGMENT denotes hair
T2481 5544-5553 UBERON:0002073 denotes follicles
T2482 5629-5634 PR:000015308 denotes Snail
T2483 5635-5643 GO:0042571 denotes antibody
T2484 5716-5721 PR:000015308 denotes Snail
T2485 5749-5758 GO:0010467 denotes expressed
T2486 5762-5775 CL:0000312 denotes keratinocytes
T2487 5865-5870 PR:000015308 denotes Snail
T2488 5879-5892 GO:0097617 denotes hybridization
T2489 5918-5923 PR:000015308 denotes Snail
T2490 5924-5934 GO:0010467 denotes expression
T2491 5942-5946 UBERON:0001037 denotes hair
T2492 6005-6010 PR:000015308 denotes Snail
T2493 6040-6049 _FRAGMENT denotes nuclei of
T2494 6063-6068 GO:0005634 denotes cells
T2495 6054-6058 UBERON:0001037 denotes hair
T2496 6115-6120 PR:000015308 denotes Snail
T2497 6197-6202 PR:000015308 denotes Snail
T2498 6275-6288 GO:0009653 denotes morphogenesis
T2499 6290-6295 PR:000015308 denotes Snail
T2500 6325-6336 UBERON:0010512 denotes guard hairs
T2501 6366-6371 UBERON:0001037 denotes hairs
T2502 6433-6438 NCBITaxon:10088 denotes mouse
T2503 6439-6443 UBERON:0010166 denotes coat
T2504 6501-6511 GO:0042571 denotes antibodies
T2505 6524-6537 GO:0008283 denotes proliferating
T2506 6538-6545 GO:0005634 denotes nuclear
T2507 6546-6553 CHEBI:59132 denotes antigen
T2508 6554-6558 PR:000010425 denotes Ki67
T2509 6574-6579 PR:000015308 denotes Snail
T2510 6580-6590 GO:0010467 denotes expression
T2511 6662-6675 GO:0008283 denotes proliferation
T2512 6731-6741 GO:0042571 denotes antibodies
T2513 6822-6835 GO:0008283 denotes proliferating
T2514 6837-6841 PR:000010425 denotes Ki67
T2515 6905-6909 UBERON:0001037 denotes hair
T2516 6941-6946 PR:000015308 denotes Snail
T2517 6961-6965 PR:000010425 denotes Ki67
T2518 6994-6998 UBERON:0001037 denotes hair
T2519 7047-7052 PR:000009751 denotes LEF-1
T2520 7053-7062 PR:000002198 denotes β-catenin
T2521 7098-7110 UBERON:0005086 denotes hair placode
T2522 7147-7151 UBERON:0001037 denotes hair
T2523 7167-7185 _FRAGMENT denotes down-regulation in
T2524 7197-7207 GO:0010629 denotes expression
T2525 7186-7196 PR:000001447 denotes E-cadherin
R1417 T2432 T2431 _lexicallyChainedTo UTR,3′
R1418 T2469 T2468 _lexicallyChainedTo cells,commitment of
R1419 T2470 T2469 _lexicallyChainedTo to,cells
R1420 T2471 T2470 _lexicallyChainedTo cell fate,to
R1421 T2473 T2472 _lexicallyChainedTo ectoderm,cells of
R1422 T2481 T2480 _lexicallyChainedTo follicles,hair
R1423 T2494 T2493 _lexicallyChainedTo cells,nuclei of
R1424 T2524 T2523 _lexicallyChainedTo expression,down-regulation in

2_test

Id Subject Object Predicate Lexical cue
15630473-14644200-84810253 309-311 14644200 denotes 18
15630473-12646922-84810254 652-653 12646922 denotes 4
15630473-12646922-84810255 749-750 12646922 denotes 4
15630473-7958926-84810256 751-753 7958926 denotes 19
15630473-10655587-84810257 6170-6172 10655587 denotes 12
15630473-10655586-84810258 6173-6175 10655586 denotes 13
15630473-10498690-84810259 7118-7120 10498690 denotes 20
15630473-12646922-84810260 7230-7231 12646922 denotes 4
T89400 309-311 14644200 denotes 18
T54398 652-653 12646922 denotes 4
T55026 749-750 12646922 denotes 4
T82528 751-753 7958926 denotes 19
T99055 6170-6172 10655587 denotes 12
T23817 6173-6175 10655586 denotes 13
T93454 7118-7120 10498690 denotes 20
T72430 7230-7231 12646922 denotes 4

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2526 0-5 PR_EXT:000015308 denotes Snail
T2527 6-10 CHEBI_SO_EXT:mRNA denotes mRNA
T2528 15-22 CHEBI_PR_EXT:protein denotes Protein
T2529 27-36 GO:0010467 denotes Expressed
T2530 56-60 UBERON:0001037 denotes Hair
T2531 74-82 UBERON_EXT:follicle denotes Follicle
T2532 83-96 GO:0009653 denotes Morphogenesis
T2533 106-111 PR_EXT:000015308 denotes Snail
T2534 163-167 GO:0001837 denotes EMTs
T2535 231-246 GO_EXT:negative_regulation denotes down-regulation
T2536 284-307 GO:0005911 denotes intercellular junctions
T2537 289-297 CL_GO_EXT:cell denotes cellular
T2538 360-365 PR_EXT:000015308 denotes Snail
T2539 428-438 UBERON:0000483 denotes epithelial
T2540 470-483 UBERON:0002073 denotes hair follicle
T2541 550-555 PR_EXT:000015308 denotes Snail
T2542 577-582 PR_EXT:000009751 denotes LEF-1
T2543 583-592 PR_EXT:000002198 denotes β-catenin
T2544 596-611 GO_EXT:negative_regulation denotes down-regulating
T2545 612-622 PR_EXT:000001447 denotes E-cadherin
T2546 623-633 GO:0010467 denotes expression
T2547 637-650 CL:0000312 denotes keratinocytes
T2548 701-706 PR_EXT:000009751 denotes LEF-1
T2549 707-716 PR_EXT:000002198 denotes β-catenin
T2550 720-733 UBERON:0002073 denotes hair follicle
T2551 720-747 GO:0031069 denotes hair follicle morphogenesis
T2552 788-793 PR_EXT:000015308 denotes Snail
T2553 794-798 PR_EXT:000015309 denotes Slug
T2554 887-892 PR_EXT:000015308 denotes Snail
T2555 893-897 CHEBI_SO_EXT:mRNA denotes mRNA
T2556 898-908 GO:0010467 denotes expression
T2557 928-932 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T2558 933-946 GO:0009790 denotes embryogenesis
T2559 961-975 UBERON:0002073 denotes hair follicles
T2560 1038-1043 PR_EXT:000015308 denotes Snail
T2561 1044-1048 CHEBI_SO_EXT:mRNA denotes mRNA
T2562 1052-1061 GO:0010467 denotes expressed
T2563 1080-1084 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T2564 1107-1120 GO:0097617 denotes hybridization
T2565 1134-1139 CHEBI_SO_EXT:molecular_probe denotes probe
T2566 1154-1159 PR_EXT:000015308 denotes Snail
T2567 1160-1182 SO_EXT:0000205 denotes 3′ untranslated region
T2568 1160-1162 _FRAGMENT denotes 3′
T2569 1184-1187 SO_EXT:0000205 denotes UTR
T2570 1165-1175 GO:0006412 denotes translated
T2571 1190-1199 UBERON:0000922 denotes Embryonic
T2572 1257-1265 UBERON_EXT:follicle denotes follicle
T2573 1266-1279 GO:0009653 denotes morphogenesis
T2574 1326-1331 PR_EXT:000015308 denotes Snail
T2575 1332-1342 GO:0010467 denotes expression
T2576 1411-1424 GO:0097617 denotes hybridization
T2577 1449-1459 UBERON:0000483 denotes epithelium
T2578 1471-1475 UBERON:0001037 denotes hair
T2579 1498-1507 UBERON_EXT:follicle denotes follicles
T2580 1609-1622 GO:0097617 denotes hybridization
T2581 1660-1665 PR_EXT:000015308 denotes Snail
T2582 1666-1670 CHEBI_SO_EXT:mRNA denotes mRNA
T2583 1671-1681 GO:0010467 denotes expression
T2584 1689-1697 UBERON_EXT:follicle denotes follicle
T2585 1731-1741 GO:0097617 denotes hybridized
T2586 1742-1746 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T2587 1767-1776 UBERON_EXT:follicle denotes follicles
T2588 1805-1818 GO:0009653 denotes morphogenesis
T2589 1843-1854 GO:0097617 denotes Hybridizing
T2590 1855-1859 UBERON:0001037 denotes hair
T2591 1911-1922 GO:0097617 denotes hybridizing
T2592 1923-1932 UBERON_EXT:follicle denotes follicles
T2593 4397-4402 PR_EXT:000015308 denotes Snail
T2594 4403-4407 CHEBI_SO_EXT:mRNA denotes mRNA
T2595 4408-4418 GO:0010467 denotes expression
T2596 4439-4446 CHEBI_PR_EXT:protein denotes protein
T2597 4470-4478 GO:0042571 denotes antibody
T2598 4491-4501 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminal
T2599 4502-4510 SO_EXT:biological_sequence denotes sequence
T2600 4524-4532 SO_EXT:sequence_upstreamness denotes upstream
T2601 4545-4554 SO_EXT:biological_conservation_process_or_quality denotes conserved
T2602 4555-4559 CHEBI_EXT:zinc denotes zinc
T2603 4567-4574 SO_EXT:0000417 denotes domains
T2604 4616-4624 GO:0042571 denotes antibody
T2605 4651-4659 CHEBI_PR_EXT:protein denotes proteins
T2606 4674-4687 CL:0000312 denotes keratinocytes
T2607 4739-4752 CL:0000312 denotes keratinocytes
T2608 4765-4775 GO:0010467 denotes expressing
T2609 4797-4803 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes tagged
T2610 4804-4809 PR_EXT:000015308 denotes Snail
T2611 4810-4817 CHEBI_PR_EXT:protein denotes protein
T2612 4835-4843 GO:0042571 denotes antibody
T2613 4907-4912 PR_EXT:000015308 denotes Snail
T2614 4952-4961 UBERON:0000922 denotes embryonic
T2615 4962-4967 NCBITaxon:10088 denotes mouse
T2616 4968-4972 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T2617 5036-5049 UBERON:0002073 denotes hair follicle
T2618 5036-5063 GO:0031069 denotes hair follicle morphogenesis
T2619 5078-5085 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T2620 5107-5111 UBERON:0010164 denotes hair
T2621 5119-5124 NCBITaxon:10088 denotes mouse
T2622 5231-5236 PR_EXT:000015308 denotes Snail
T2623 5261-5270 UBERON:0007376 denotes epidermis
T2624 5294-5301 UBERON_EXT:placode denotes placode
T2625 5351-5364 _FRAGMENT denotes commitment of
T2626 5377-5382 _FRAGMENT denotes cells
T2627 5409-5411 _FRAGMENT denotes to
T2628 5419-5428 GO:0045165 denotes cell fate
T2629 5377-5382 CL_GO_EXT:cell denotes cells
T2630 5377-5385 _FRAGMENT denotes cells of
T2631 5400-5408 CL:0000221 denotes ectoderm
T2632 5390-5408 UBERON:0000924 denotes embryonic ectoderm
T2633 5414-5418 UBERON:0001037 denotes hair
T2634 5414-5423 CL:0002559 denotes hair cell
T2635 5419-5423 CL_GO_EXT:cell denotes cell
T2636 5470-5483 GO:0097617 denotes hybridization
T2637 5498-5503 PR_EXT:000015308 denotes Snail
T2638 5504-5512 GO:0042571 denotes antibody
T2639 5513-5520 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T2640 5526-5530 _FRAGMENT denotes hair
T2641 5544-5553 UBERON:0002073 denotes follicles
T2642 5629-5634 PR_EXT:000015308 denotes Snail
T2643 5635-5643 GO:0042571 denotes antibody
T2644 5683-5690 CHEBI_PR_EXT:protein denotes protein
T2645 5716-5721 PR_EXT:000015308 denotes Snail
T2646 5749-5758 GO:0010467 denotes expressed
T2647 5762-5775 CL:0000312 denotes keratinocytes
T2648 5783-5787 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T2649 5865-5870 PR_EXT:000015308 denotes Snail
T2650 5879-5892 GO:0097617 denotes hybridization
T2651 5918-5923 PR_EXT:000015308 denotes Snail
T2652 5924-5934 GO:0010467 denotes expression
T2653 5942-5946 UBERON:0001037 denotes hair
T2654 6005-6010 PR_EXT:000015308 denotes Snail
T2655 6011-6018 CHEBI_PR_EXT:protein denotes protein
T2656 6023-6032 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T2657 6040-6049 _FRAGMENT denotes nuclei of
T2658 6063-6068 GO:0005634 denotes cells
T2659 6054-6058 UBERON:0001037 denotes hair
T2660 6063-6068 CL_GO_EXT:cell denotes cells
T2661 6115-6120 PR_EXT:000015308 denotes Snail
T2662 6143-6158 GO_EXT:transcription denotes transcriptional
T2663 6197-6202 PR_EXT:000015308 denotes Snail
T2664 6203-6211 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeling
T2665 6266-6274 UBERON_EXT:follicle denotes follicle
T2666 6275-6288 GO:0009653 denotes morphogenesis
T2667 6290-6295 PR_EXT:000015308 denotes Snail
T2668 6325-6336 UBERON:0010512 denotes guard hairs
T2669 6366-6371 UBERON:0001037 denotes hairs
T2670 6433-6438 NCBITaxon:10088 denotes mouse
T2671 6439-6443 UBERON:0010166 denotes coat
T2672 6501-6511 GO:0042571 denotes antibodies
T2673 6524-6537 GO:0008283 denotes proliferating
T2674 6538-6545 GO:0005634 denotes nuclear
T2675 6546-6553 CHEBI_EXT:59132 denotes antigen
T2676 6554-6558 PR_EXT:000010425 denotes Ki67
T2677 6574-6579 PR_EXT:000015308 denotes Snail
T2678 6580-6590 GO:0010467 denotes expression
T2679 6640-6648 UBERON_EXT:follicle denotes follicle
T2680 6662-6675 GO:0008283 denotes proliferation
T2681 6685-6691 GO_EXT:biological_growth_entity_or_process denotes growth
T2682 6731-6741 GO:0042571 denotes antibodies
T2683 6762-6776 GO_PATO_EXT:phosphorylation_process_or_quality denotes phosphorylated
T2684 6786-6790 GO_PR_EXT:MAP_kinase denotes MAPK
T2685 6799-6805 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes marked
T2686 6822-6835 GO:0008283 denotes proliferating
T2687 6837-6841 PR_EXT:000010425 denotes Ki67
T2688 6852-6857 CL_GO_EXT:cell denotes cells
T2689 6878-6883 CL_GO_EXT:cell denotes cells
T2690 6905-6909 UBERON:0001037 denotes hair
T2691 6941-6946 PR_EXT:000015308 denotes Snail
T2692 6961-6965 PR_EXT:000010425 denotes Ki67
T2693 6994-6998 UBERON:0001037 denotes hair
T2694 7047-7052 PR_EXT:000009751 denotes LEF-1
T2695 7053-7062 PR_EXT:000002198 denotes β-catenin
T2696 7098-7110 UBERON:0005086 denotes hair placode
T2697 7137-7145 UBERON_EXT:placode denotes placodes
T2698 7147-7151 UBERON:0001037 denotes hair
T2699 7167-7185 _FRAGMENT denotes down-regulation in
T2700 7197-7207 GO:0010629 denotes expression
T2701 7186-7196 PR_EXT:000001447 denotes E-cadherin
R1427 T2627 T2626 _lexicallyChainedTo to,cells
R1428 T2628 T2627 _lexicallyChainedTo cell fate,to
R1429 T2631 T2630 _lexicallyChainedTo ectoderm,cells of
R1430 T2641 T2640 _lexicallyChainedTo follicles,hair
R1431 T2658 T2657 _lexicallyChainedTo cells,nuclei of
R1432 T2700 T2699 _lexicallyChainedTo expression,down-regulation in
R1425 T2569 T2568 _lexicallyChainedTo UTR,3′
R1426 T2626 T2625 _lexicallyChainedTo cells,commitment of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T2702 0-5 NN denotes Snail
T2703 6-10 NN denotes mRNA
T2704 27-36 VBN denotes Expressed
T2705 11-14 CC denotes and
T2706 15-22 NN denotes Protein
T2707 23-26 VBP denotes Are
T2708 37-48 RB denotes Transiently
T2709 49-51 IN denotes at
T2710 52-55 DT denotes the
T2711 65-70 NN denotes Stage
T2712 56-60 NN denotes Hair
T2713 61-64 NN denotes Bud
T2714 71-73 IN denotes of
T2715 74-82 NN denotes Follicle
T2716 83-96 NN denotes Morphogenesis
T2717 96-313 sentence denotes Although Snail family members are most frequently associated with EMTs, they also participate in many malignant processes involving a down-regulation but not a quantitative abrogation of intercellular junctions [18].
T2718 97-105 IN denotes Although
T2719 147-157 VBN denotes associated
T2720 106-111 NN denotes Snail
T2721 119-126 NNS denotes members
T2722 112-118 NN denotes family
T2723 127-130 VBP denotes are
T2724 131-135 RBS denotes most
T2725 136-146 RB denotes frequently
T2726 179-190 VBP denotes participate
T2727 158-162 IN denotes with
T2728 163-167 NNS denotes EMTs
T2729 167-169 , denotes ,
T2730 169-173 PRP denotes they
T2731 174-178 RB denotes also
T2732 191-193 IN denotes in
T2733 194-198 JJ denotes many
T2734 209-218 NNS denotes processes
T2735 199-208 JJ denotes malignant
T2736 219-228 VBG denotes involving
T2737 229-230 DT denotes a
T2738 236-246 NN denotes regulation
T2739 231-235 JJ denotes down
T2740 235-236 HYPH denotes -
T2741 247-250 CC denotes but
T2742 251-254 RB denotes not
T2743 255-256 DT denotes a
T2744 270-280 NN denotes abrogation
T2745 257-269 JJ denotes quantitative
T2746 281-283 IN denotes of
T2747 284-297 JJ denotes intercellular
T2748 298-307 NNS denotes junctions
T2749 308-309 -LRB- denotes [
T2750 309-311 CD denotes 18
T2751 311-312 -RRB- denotes ]
T2752 312-313 . denotes .
T2753 313-498 sentence denotes The range of developmental processes in which Snail family members have been implicated thus includes the type of epithelial remodeling that is observed in hair follicle bud formation.
T2754 314-317 DT denotes The
T2755 318-323 NN denotes range
T2756 407-415 VBZ denotes includes
T2757 324-326 IN denotes of
T2758 327-340 JJ denotes developmental
T2759 341-350 NNS denotes processes
T2760 351-353 IN denotes in
T2761 391-401 VBN denotes implicated
T2762 354-359 WDT denotes which
T2763 360-365 NN denotes Snail
T2764 373-380 NNS denotes members
T2765 366-372 NN denotes family
T2766 381-385 VBP denotes have
T2767 386-390 VBN denotes been
T2768 402-406 RB denotes thus
T2769 416-419 DT denotes the
T2770 420-424 NN denotes type
T2771 425-427 IN denotes of
T2772 428-438 JJ denotes epithelial
T2773 439-449 NN denotes remodeling
T2774 450-454 WDT denotes that
T2775 458-466 VBN denotes observed
T2776 455-457 VBZ denotes is
T2777 467-469 IN denotes in
T2778 470-474 NN denotes hair
T2779 475-483 NN denotes follicle
T2780 484-487 NN denotes bud
T2781 488-497 NN denotes formation
T2782 497-498 . denotes .
T2783 498-852 sentence denotes Given our prior observation that exogenously added Snail can participate with LEF-1/β-catenin in down-regulating E-cadherin expression in keratinocytes [4], coupled with the established requirement for LEF-1/β-catenin in hair follicle morphogenesis [4,19], we turned to addressing whether Snail/Slug family members might also participate in the process.
T2784 499-504 VBN denotes Given
T2785 759-765 VBD denotes turned
T2786 505-508 PRP$ denotes our
T2787 515-526 NN denotes observation
T2788 509-514 JJ denotes prior
T2789 527-531 IN denotes that
T2790 560-571 VB denotes participate
T2791 532-543 RB denotes exogenously
T2792 544-549 VBN denotes added
T2793 550-555 NN denotes Snail
T2794 556-559 MD denotes can
T2795 572-576 IN denotes with
T2796 577-580 NN denotes LEF
T2797 580-581 HYPH denotes -
T2798 581-582 CD denotes 1
T2799 582-583 HYPH denotes /
T2800 583-584 NN denotes β
T2801 585-592 NN denotes catenin
T2802 584-585 HYPH denotes -
T2803 593-595 IN denotes in
T2804 596-600 RB denotes down
T2805 601-611 VBG denotes regulating
T2806 600-601 HYPH denotes -
T2807 612-613 NN denotes E
T2808 614-622 NN denotes cadherin
T2809 613-614 HYPH denotes -
T2810 623-633 NN denotes expression
T2811 634-636 IN denotes in
T2812 637-650 NNS denotes keratinocytes
T2813 651-652 -LRB- denotes [
T2814 652-653 CD denotes 4
T2815 653-654 -RRB- denotes ]
T2816 654-656 , denotes ,
T2817 656-663 VBN denotes coupled
T2818 664-668 IN denotes with
T2819 669-672 DT denotes the
T2820 685-696 NN denotes requirement
T2821 673-684 JJ denotes established
T2822 697-700 IN denotes for
T2823 701-704 NN denotes LEF
T2824 704-705 HYPH denotes -
T2825 705-706 CD denotes 1
T2826 706-707 HYPH denotes /
T2827 707-708 NN denotes β
T2828 709-716 NN denotes catenin
T2829 708-709 HYPH denotes -
T2830 717-719 IN denotes in
T2831 720-724 NN denotes hair
T2832 725-733 NN denotes follicle
T2833 734-747 NN denotes morphogenesis
T2834 748-749 -LRB- denotes [
T2835 751-753 CD denotes 19
T2836 749-750 CD denotes 4
T2837 750-751 , denotes ,
T2838 753-754 -RRB- denotes ]
T2839 754-756 , denotes ,
T2840 756-758 PRP denotes we
T2841 766-768 IN denotes to
T2842 769-779 VBG denotes addressing
T2843 780-787 IN denotes whether
T2844 825-836 VB denotes participate
T2845 788-793 NN denotes Snail
T2846 794-798 NN denotes Slug
T2847 793-794 HYPH denotes /
T2848 806-813 NNS denotes members
T2849 799-805 NN denotes family
T2850 814-819 MD denotes might
T2851 820-824 RB denotes also
T2852 837-839 IN denotes in
T2853 840-843 DT denotes the
T2854 844-851 NN denotes process
T2855 851-852 . denotes .
T2856 852-1007 sentence denotes PCR analyses identified transient Snail mRNA expression during a period of skin embryogenesis when waves of hair follicles are forming (unpublished data).
T2857 853-856 NN denotes PCR
T2858 857-865 NNS denotes analyses
T2859 866-876 VBD denotes identified
T2860 877-886 JJ denotes transient
T2861 898-908 NN denotes expression
T2862 887-892 NN denotes Snail
T2863 893-897 NN denotes mRNA
T2864 909-915 IN denotes during
T2865 916-917 DT denotes a
T2866 918-924 NN denotes period
T2867 925-927 IN denotes of
T2868 928-932 NN denotes skin
T2869 933-946 NN denotes embryogenesis
T2870 947-951 WRB denotes when
T2871 980-987 VBG denotes forming
T2872 952-957 NNS denotes waves
T2873 958-960 IN denotes of
T2874 961-965 NN denotes hair
T2875 966-975 NNS denotes follicles
T2876 976-979 VBP denotes are
T2877 988-989 -LRB- denotes (
T2878 1001-1005 NNS denotes data
T2879 989-1000 JJ denotes unpublished
T2880 1005-1006 -RRB- denotes )
T2881 1006-1007 . denotes .
T2882 1007-1009 TO denotes To
T2883 1010-1018 VB denotes pinpoint
T2884 1007-1189 sentence denotes To pinpoint specifically where Snail mRNA is expressed in the developing skin, we conducted in situ hybridization using a cRNA probe unique to the Snail 3′ untranslated region (UTR).
T2885 1089-1098 VBD denotes conducted
T2886 1019-1031 RB denotes specifically
T2887 1032-1037 WRB denotes where
T2888 1052-1061 VBN denotes expressed
T2889 1038-1043 NN denotes Snail
T2890 1044-1048 NN denotes mRNA
T2891 1049-1051 VBZ denotes is
T2892 1062-1064 IN denotes in
T2893 1065-1068 DT denotes the
T2894 1080-1084 NN denotes skin
T2895 1069-1079 VBG denotes developing
T2896 1084-1086 , denotes ,
T2897 1086-1088 PRP denotes we
T2898 1099-1101 FW denotes in
T2899 1102-1106 FW denotes situ
T2900 1107-1120 NN denotes hybridization
T2901 1121-1126 VBG denotes using
T2902 1127-1128 DT denotes a
T2903 1134-1139 NN denotes probe
T2904 1129-1133 NN denotes cRNA
T2905 1140-1146 JJ denotes unique
T2906 1147-1149 IN denotes to
T2907 1150-1153 DT denotes the
T2908 1176-1182 NN denotes region
T2909 1154-1159 NNP denotes Snail
T2910 1160-1161 CD denotes 3
T2911 1161-1162 SYM denotes ′
T2912 1163-1175 JJ denotes untranslated
T2913 1183-1184 -LRB- denotes (
T2914 1184-1187 NN denotes UTR
T2915 1187-1188 -RRB- denotes )
T2916 1188-1189 . denotes .
T2917 1189-1378 sentence denotes Embryonic day 17.5 (E17.5) was chosen, since the multiple waves of follicle morphogenesis occurring at this time enabled us to evaluate Snail expression at different stages of the process.
T2918 1190-1199 JJ denotes Embryonic
T2919 1200-1203 NN denotes day
T2920 1221-1227 VBN denotes chosen
T2921 1204-1208 CD denotes 17.5
T2922 1209-1210 -LRB- denotes (
T2923 1210-1215 NN denotes E17.5
T2924 1215-1216 -RRB- denotes )
T2925 1217-1220 VBD denotes was
T2926 1227-1229 , denotes ,
T2927 1229-1234 IN denotes since
T2928 1303-1310 VBD denotes enabled
T2929 1235-1238 DT denotes the
T2930 1248-1253 NNS denotes waves
T2931 1239-1247 JJ denotes multiple
T2932 1254-1256 IN denotes of
T2933 1257-1265 NN denotes follicle
T2934 1266-1279 NN denotes morphogenesis
T2935 1280-1289 VBG denotes occurring
T2936 1290-1292 IN denotes at
T2937 1293-1297 DT denotes this
T2938 1298-1302 NN denotes time
T2939 1311-1313 PRP denotes us
T2940 1314-1316 TO denotes to
T2941 1317-1325 VB denotes evaluate
T2942 1326-1331 NN denotes Snail
T2943 1332-1342 NN denotes expression
T2944 1343-1345 IN denotes at
T2945 1346-1355 JJ denotes different
T2946 1356-1362 NNS denotes stages
T2947 1363-1365 IN denotes of
T2948 1366-1369 DT denotes the
T2949 1370-1377 NN denotes process
T2950 1377-1378 . denotes .
T2951 1378-1481 sentence denotes As shown in Figure 1A, specific hybridization was detected within the epithelium of nascent hair buds.
T2952 1379-1381 IN denotes As
T2953 1382-1387 VBN denotes shown
T2954 1429-1437 VBN denotes detected
T2955 1388-1390 IN denotes in
T2956 1391-1397 NN denotes Figure
T2957 1398-1400 NN denotes 1A
T2958 1400-1402 , denotes ,
T2959 1402-1410 JJ denotes specific
T2960 1411-1424 NN denotes hybridization
T2961 1425-1428 VBD denotes was
T2962 1438-1444 IN denotes within
T2963 1445-1448 DT denotes the
T2964 1449-1459 NN denotes epithelium
T2965 1460-1462 IN denotes of
T2966 1463-1470 JJ denotes nascent
T2967 1476-1480 NNS denotes buds
T2968 1471-1475 NN denotes hair
T2969 1480-1481 . denotes .
T2970 1481-1635 sentence denotes By contrast, as follicles progressed further through their development (e.g., germ and peg stages), they exhibited no signs of hybridization (Figure 1A).
T2971 1482-1484 IN denotes By
T2972 1587-1596 VBD denotes exhibited
T2973 1485-1493 NN denotes contrast
T2974 1493-1495 , denotes ,
T2975 1495-1497 IN denotes as
T2976 1508-1518 VBD denotes progressed
T2977 1498-1507 NNS denotes follicles
T2978 1519-1526 RBR denotes further
T2979 1527-1534 IN denotes through
T2980 1535-1540 PRP$ denotes their
T2981 1541-1552 NN denotes development
T2982 1553-1554 -LRB- denotes (
T2983 1573-1579 NNS denotes stages
T2984 1554-1558 FW denotes e.g.
T2985 1558-1560 , denotes ,
T2986 1560-1564 NN denotes germ
T2987 1565-1568 CC denotes and
T2988 1569-1572 NN denotes peg
T2989 1579-1580 -RRB- denotes )
T2990 1580-1582 , denotes ,
T2991 1582-1586 PRP denotes they
T2992 1597-1599 DT denotes no
T2993 1600-1605 NNS denotes signs
T2994 1606-1608 IN denotes of
T2995 1609-1622 NN denotes hybridization
T2996 1623-1624 -LRB- denotes (
T2997 1631-1633 NN denotes 1A
T2998 1624-1630 NN denotes Figure
T2999 1633-1634 -RRB- denotes )
T3000 1634-1635 . denotes .
T3001 1635-1842 sentence denotes The transient nature of Snail mRNA expression during follicle development was most apparent in hybridized skin sections containing follicles from two different waves of morphogenesis (as shown in Figure 1).
T3002 1636-1639 DT denotes The
T3003 1650-1656 NN denotes nature
T3004 1640-1649 JJ denotes transient
T3005 1710-1713 VBD denotes was
T3006 1657-1659 IN denotes of
T3007 1660-1665 NN denotes Snail
T3008 1671-1681 NN denotes expression
T3009 1666-1670 NN denotes mRNA
T3010 1682-1688 IN denotes during
T3011 1689-1697 NN denotes follicle
T3012 1698-1709 NN denotes development
T3013 1714-1718 RBS denotes most
T3014 1719-1727 JJ denotes apparent
T3015 1728-1730 IN denotes in
T3016 1731-1741 VBN denotes hybridized
T3017 1747-1755 NNS denotes sections
T3018 1742-1746 NN denotes skin
T3019 1756-1766 VBG denotes containing
T3020 1767-1776 NNS denotes follicles
T3021 1777-1781 IN denotes from
T3022 1782-1785 CD denotes two
T3023 1796-1801 NNS denotes waves
T3024 1786-1795 JJ denotes different
T3025 1802-1804 IN denotes of
T3026 1805-1818 NN denotes morphogenesis
T3027 1819-1820 -LRB- denotes (
T3028 1823-1828 VBN denotes shown
T3029 1820-1822 IN denotes as
T3030 1829-1831 IN denotes in
T3031 1832-1838 NN denotes Figure
T3032 1839-1840 CD denotes 1
T3033 1840-1841 -RRB- denotes )
T3034 1841-1842 . denotes .
T3035 1842-1954 sentence denotes Hybridizing hair buds from a later wave appeared juxtaposed with nonhybridizing follicles from an earlier wave.
T3036 1843-1854 VBG denotes Hybridizing
T3037 1860-1864 NNS denotes buds
T3038 1855-1859 NN denotes hair
T3039 1883-1891 VBD denotes appeared
T3040 1865-1869 IN denotes from
T3041 1870-1871 DT denotes a
T3042 1878-1882 NN denotes wave
T3043 1872-1877 JJ denotes later
T3044 1892-1902 JJ denotes juxtaposed
T3045 1903-1907 IN denotes with
T3046 1908-1922 JJ denotes nonhybridizing
T3047 1923-1932 NNS denotes follicles
T3048 1933-1937 IN denotes from
T3049 1938-1940 DT denotes an
T3050 1949-1953 NN denotes wave
T3051 1941-1948 JJR denotes earlier
T3052 1953-1954 . denotes .
T3053 1954-4575 sentence denotes Figure 1 Snail Is Expressed Exclusively in the Hair Bud during Morphogenesis Embryos were either frozen in OCT embedding compound (A, F, and H) or embedded in paraffin (C, D, E, and G), and then sectioned (8 μm). (A) In situ hybridizations with Snail sense or antisense cRNA probes. Black dotted lines demarcate the basement membrane that separates the epidermis (epi) from dermis (der). Arrows point to Snail RNA expression, restricted to the hair bud stage of follicle morphogenesis. It was not seen in later hair germ or peg stages. (B) Expression of Snail protein coincides with hair development. Protein extracts were prepared from keratinocytes transfected with empty expression vector (K14), containing the K14 promoter or with the vector driving HA-tagged Snail (K14-Snail); or from whole skin from E13.5 to P5 animals, including newborn (nb). Equal amounts of proteins were then resolved by SDS-PAGE through 12% gels and subjected to Western blotting using either an affinity-purified Snail polyclonal antiserum, which we generated, or anti-tubulin (loading control). (C–E) Immunohistochemistry shows expression of Snail protein in the nuclei of cells within the hair and skin. (C) E13.5 skin with a single layered epidermis (epi) shows no Snail expression. (D) The first morphological sign that cells have adopted a hair follicle fate is a cluster of cells called a placode in E16.5 skin. Snail is not expressed at this stage of development. (E) Snail is expressed in the hair bud of E17.5 skin but not in later stages of development such as the germ or peg. (F) Immunofluorescence with anti-Ki67 (green) identifies the proliferating cells of the skin, restricted to the basal layer of the epidermis and developing hair follicles. Anti-β4 int labeling reveals the presence of the hemidesmosomal integrin β4, restricted to the base of cells adhering to the underlying basement membrane. The white dotted line marks the outermost surface of the skin. (G) Immunohistochemistry with pMAPK marks a subset of proliferating cells within the epidermis and hair bud. Anti-pMAPK labeling was consistently robust within the hair bud. (H) Immunofluorescence with anti-laminin 5 (lam5), which demarcates the basement membrane, and anti-E-cadherin (E-cad), a component of AJs. At the leading edge of the growing bud, cell-cell borders show markedly diminished anti-E-cadherin labeling (arrowheads). To determine whether this transient nature of Snail mRNA expression is reflected at the protein level, we generated an antibody against the N-terminal sequence that resides upstream of the more conserved zinc finger domains.
T3054 4351-4353 TO denotes To
T3055 4354-4363 VB denotes determine
T3056 4457-4466 VBD denotes generated
T3057 4364-4371 IN denotes whether
T3058 4422-4431 VBN denotes reflected
T3059 4372-4376 DT denotes this
T3060 4387-4393 NN denotes nature
T3061 4377-4386 JJ denotes transient
T3062 4394-4396 IN denotes of
T3063 4397-4402 NN denotes Snail
T3064 4408-4418 NN denotes expression
T3065 4403-4407 NN denotes mRNA
T3066 4419-4421 VBZ denotes is
T3067 4432-4434 IN denotes at
T3068 4435-4438 DT denotes the
T3069 4447-4452 NN denotes level
T3070 4439-4446 NN denotes protein
T3071 4452-4454 , denotes ,
T3072 4454-4456 PRP denotes we
T3073 4467-4469 DT denotes an
T3074 4470-4478 NN denotes antibody
T3075 4479-4486 IN denotes against
T3076 4487-4490 DT denotes the
T3077 4502-4510 NN denotes sequence
T3078 4491-4492 NN denotes N
T3079 4493-4501 JJ denotes terminal
T3080 4492-4493 HYPH denotes -
T3081 4511-4515 WDT denotes that
T3082 4516-4523 VBZ denotes resides
T3083 4524-4532 RB denotes upstream
T3084 4533-4535 IN denotes of
T3085 4536-4539 DT denotes the
T3086 4567-4574 NNS denotes domains
T3087 4540-4544 RBR denotes more
T3088 4545-4554 VBN denotes conserved
T3089 4555-4559 NN denotes zinc
T3090 4560-4566 NN denotes finger
T3091 4574-4575 . denotes .
T3092 4575-4830 sentence denotes As judged by Western blot analysis, the antibody did not detect endogenous proteins from cultured keratinocytes, but it did yield a band of the expected size from keratinocytes transiently expressing a hemagglutinin (HA)-tagged Snail protein (Figure 1B).
T3093 4576-4578 IN denotes As
T3094 4579-4585 VBN denotes judged
T3095 4633-4639 VB denotes detect
T3096 4586-4588 IN denotes by
T3097 4589-4596 NNP denotes Western
T3098 4597-4601 NN denotes blot
T3099 4602-4610 NN denotes analysis
T3100 4610-4612 , denotes ,
T3101 4612-4615 DT denotes the
T3102 4616-4624 NN denotes antibody
T3103 4625-4628 VBD denotes did
T3104 4629-4632 RB denotes not
T3105 4640-4650 JJ denotes endogenous
T3106 4651-4659 NN denotes proteins
T3107 4660-4664 IN denotes from
T3108 4665-4673 VBN denotes cultured
T3109 4674-4687 NNS denotes keratinocytes
T3110 4687-4689 , denotes ,
T3111 4689-4692 CC denotes but
T3112 4693-4695 PRP denotes it
T3113 4700-4705 VB denotes yield
T3114 4696-4699 VBD denotes did
T3115 4706-4707 DT denotes a
T3116 4708-4712 NN denotes band
T3117 4713-4715 IN denotes of
T3118 4716-4719 DT denotes the
T3119 4729-4733 NN denotes size
T3120 4720-4728 VBN denotes expected
T3121 4734-4738 IN denotes from
T3122 4739-4752 NNS denotes keratinocytes
T3123 4753-4764 RB denotes transiently
T3124 4765-4775 VBG denotes expressing
T3125 4776-4777 DT denotes a
T3126 4810-4817 NN denotes protein
T3127 4778-4791 NN denotes hemagglutinin
T3128 4797-4803 VBN denotes tagged
T3129 4792-4793 -LRB- denotes (
T3130 4793-4795 NN denotes HA
T3131 4795-4796 -RRB- denotes )
T3132 4796-4797 HYPH denotes -
T3133 4804-4809 NN denotes Snail
T3134 4818-4819 -LRB- denotes (
T3135 4826-4828 NN denotes 1B
T3136 4819-4825 NN denotes Figure
T3137 4828-4829 -RRB- denotes )
T3138 4829-4830 . denotes .
T3139 4830-5147 sentence denotes The antibody also recognized a band corresponding to the size of endogenous Snail (approximately 28 kDa) in lysates from embryonic mouse skin, the temporal appearance of which corresponded to the waves of hair follicle morphogenesis from E15.5 to newborn when over 90% of the hair on the mouse is formed (Figure 1B).
T3140 4831-4834 DT denotes The
T3141 4835-4843 NN denotes antibody
T3142 4849-4859 VBD denotes recognized
T3143 4844-4848 RB denotes also
T3144 4860-4861 DT denotes a
T3145 4862-4866 NN denotes band
T3146 4867-4880 VBG denotes corresponding
T3147 4881-4883 IN denotes to
T3148 4884-4887 DT denotes the
T3149 4888-4892 NN denotes size
T3150 4893-4895 IN denotes of
T3151 4896-4906 JJ denotes endogenous
T3152 4907-4912 NN denotes Snail
T3153 4913-4914 -LRB- denotes (
T3154 4914-4927 RB denotes approximately
T3155 4928-4930 CD denotes 28
T3156 4931-4934 NN denotes kDa
T3157 4934-4935 -RRB- denotes )
T3158 4936-4938 IN denotes in
T3159 4939-4946 NNS denotes lysates
T3160 4947-4951 IN denotes from
T3161 4952-4961 JJ denotes embryonic
T3162 4968-4972 NN denotes skin
T3163 4962-4967 NN denotes mouse
T3164 4972-4974 , denotes ,
T3165 4974-4977 DT denotes the
T3166 4987-4997 NN denotes appearance
T3167 4978-4986 JJ denotes temporal
T3168 5007-5019 VBD denotes corresponded
T3169 4998-5000 IN denotes of
T3170 5001-5006 WDT denotes which
T3171 5020-5022 IN denotes to
T3172 5023-5026 DT denotes the
T3173 5027-5032 NNS denotes waves
T3174 5033-5035 IN denotes of
T3175 5036-5040 NN denotes hair
T3176 5041-5049 NN denotes follicle
T3177 5050-5063 NN denotes morphogenesis
T3178 5064-5068 IN denotes from
T3179 5069-5074 NN denotes E15.5
T3180 5075-5077 IN denotes to
T3181 5078-5085 JJ denotes newborn
T3182 5086-5090 WRB denotes when
T3183 5128-5134 VBN denotes formed
T3184 5091-5095 IN denotes over
T3185 5096-5098 CD denotes 90
T3186 5098-5099 NN denotes %
T3187 5100-5102 IN denotes of
T3188 5103-5106 DT denotes the
T3189 5107-5111 NN denotes hair
T3190 5112-5114 IN denotes on
T3191 5115-5118 DT denotes the
T3192 5119-5124 NN denotes mouse
T3193 5125-5127 VBZ denotes is
T3194 5135-5136 -LRB- denotes (
T3195 5143-5145 NN denotes 1B
T3196 5136-5142 NN denotes Figure
T3197 5145-5146 -RRB- denotes )
T3198 5146-5147 . denotes .
T3199 5147-5441 sentence denotes Consistent with the Western blot data, immunohistochemical analysis did not detect Snail in single-layered E13.5 epidermis (Figure 1C) nor in the placode, which is the earliest morphological sign of the commitment of multipotent cells of the embryonic ectoderm to a hair cell fate (Figure 1D).
T3200 5148-5158 JJ denotes Consistent
T3201 5224-5230 VB denotes detect
T3202 5159-5163 IN denotes with
T3203 5164-5167 DT denotes the
T3204 5181-5185 NNS denotes data
T3205 5168-5175 NNP denotes Western
T3206 5176-5180 NN denotes blot
T3207 5185-5187 , denotes ,
T3208 5187-5206 JJ denotes immunohistochemical
T3209 5207-5215 NN denotes analysis
T3210 5216-5219 VBD denotes did
T3211 5220-5223 RB denotes not
T3212 5231-5236 NN denotes Snail
T3213 5237-5239 IN denotes in
T3214 5240-5246 JJ denotes single
T3215 5247-5254 JJ denotes layered
T3216 5246-5247 HYPH denotes -
T3217 5261-5270 NN denotes epidermis
T3218 5255-5260 NN denotes E13.5
T3219 5271-5272 -LRB- denotes (
T3220 5279-5281 NN denotes 1C
T3221 5272-5278 NN denotes Figure
T3222 5281-5282 -RRB- denotes )
T3223 5283-5286 CC denotes nor
T3224 5287-5289 IN denotes in
T3225 5290-5293 DT denotes the
T3226 5294-5301 NN denotes placode
T3227 5301-5303 , denotes ,
T3228 5303-5308 WDT denotes which
T3229 5309-5311 VBZ denotes is
T3230 5312-5315 DT denotes the
T3231 5339-5343 NN denotes sign
T3232 5316-5324 JJS denotes earliest
T3233 5325-5338 JJ denotes morphological
T3234 5344-5346 IN denotes of
T3235 5347-5350 DT denotes the
T3236 5351-5361 NN denotes commitment
T3237 5362-5364 IN denotes of
T3238 5365-5376 JJ denotes multipotent
T3239 5377-5382 NNS denotes cells
T3240 5383-5385 IN denotes of
T3241 5386-5389 DT denotes the
T3242 5400-5408 NN denotes ectoderm
T3243 5390-5399 JJ denotes embryonic
T3244 5409-5411 IN denotes to
T3245 5412-5413 DT denotes a
T3246 5424-5428 NN denotes fate
T3247 5414-5418 NN denotes hair
T3248 5419-5423 NN denotes cell
T3249 5429-5430 -LRB- denotes (
T3250 5437-5439 NN denotes 1D
T3251 5430-5436 NN denotes Figure
T3252 5439-5440 -RRB- denotes )
T3253 5440-5441 . denotes .
T3254 5441-5603 sentence denotes Consistent with the in situ hybridization results, anti-Snail antibody labeled only hair buds and not follicles at more mature stages of development (Figure 1E).
T3255 5442-5452 JJ denotes Consistent
T3256 5513-5520 VBD denotes labeled
T3257 5453-5457 IN denotes with
T3258 5458-5461 DT denotes the
T3259 5484-5491 NNS denotes results
T3260 5462-5464 FW denotes in
T3261 5465-5469 FW denotes situ
T3262 5470-5483 NN denotes hybridization
T3263 5491-5493 , denotes ,
T3264 5493-5503 JJ denotes anti-Snail
T3265 5504-5512 NN denotes antibody
T3266 5521-5525 RB denotes only
T3267 5531-5535 NNS denotes buds
T3268 5526-5530 NN denotes hair
T3269 5536-5539 CC denotes and
T3270 5540-5543 RB denotes not
T3271 5544-5553 NNS denotes follicles
T3272 5554-5556 IN denotes at
T3273 5557-5561 RBR denotes more
T3274 5569-5575 NNS denotes stages
T3275 5562-5568 JJ denotes mature
T3276 5576-5578 IN denotes of
T3277 5579-5590 NN denotes development
T3278 5591-5592 -LRB- denotes (
T3279 5599-5601 NN denotes 1E
T3280 5592-5598 NN denotes Figure
T3281 5601-5602 -RRB- denotes )
T3282 5602-5603 . denotes .
T3283 5603-5691 sentence denotes Taken together, the anti-Snail antibody appeared to be specific for its target protein.
T3284 5604-5609 VBN denotes Taken
T3285 5644-5652 VBD denotes appeared
T3286 5610-5618 RB denotes together
T3287 5618-5620 , denotes ,
T3288 5620-5623 DT denotes the
T3289 5635-5643 NN denotes antibody
T3290 5624-5634 JJ denotes anti-Snail
T3291 5653-5655 TO denotes to
T3292 5656-5658 VB denotes be
T3293 5659-5667 JJ denotes specific
T3294 5668-5671 IN denotes for
T3295 5672-5675 PRP$ denotes its
T3296 5683-5690 NN denotes protein
T3297 5676-5682 NN denotes target
T3298 5690-5691 . denotes .
T3299 5691-5807 sentence denotes It did not detect other Snail family members known to be expressed in keratinocytes and/or skin (unpublished data).
T3300 5692-5694 PRP denotes It
T3301 5703-5709 VB denotes detect
T3302 5695-5698 VBD denotes did
T3303 5699-5702 RB denotes not
T3304 5710-5715 JJ denotes other
T3305 5729-5736 NNS denotes members
T3306 5716-5721 NN denotes Snail
T3307 5722-5728 NN denotes family
T3308 5737-5742 VBN denotes known
T3309 5743-5745 TO denotes to
T3310 5749-5758 VBN denotes expressed
T3311 5746-5748 VB denotes be
T3312 5759-5761 IN denotes in
T3313 5762-5775 NNS denotes keratinocytes
T3314 5776-5779 CC denotes and
T3315 5779-5780 HYPH denotes /
T3316 5780-5782 CC denotes or
T3317 5783-5787 NN denotes skin
T3318 5788-5789 -LRB- denotes (
T3319 5801-5805 NNS denotes data
T3320 5789-5800 JJ denotes unpublished
T3321 5805-5806 -RRB- denotes )
T3322 5806-5807 . denotes .
T3323 5807-5969 sentence denotes Furthermore, the immunohistochemical data paralleled our Snail in situ hybridization data revealing transient Snail expression at the hair bud stage (Figure 1A).
T3324 5808-5819 RB denotes Furthermore
T3325 5850-5860 VBD denotes paralleled
T3326 5819-5821 , denotes ,
T3327 5821-5824 DT denotes the
T3328 5845-5849 NNS denotes data
T3329 5825-5844 JJ denotes immunohistochemical
T3330 5861-5864 PRP$ denotes our
T3331 5893-5897 NNS denotes data
T3332 5865-5870 NN denotes Snail
T3333 5879-5892 NN denotes hybridization
T3334 5871-5873 FW denotes in
T3335 5874-5878 FW denotes situ
T3336 5898-5907 VBG denotes revealing
T3337 5908-5917 JJ denotes transient
T3338 5924-5934 NN denotes expression
T3339 5918-5923 NN denotes Snail
T3340 5935-5937 IN denotes at
T3341 5938-5941 DT denotes the
T3342 5951-5956 NN denotes stage
T3343 5942-5946 NN denotes hair
T3344 5947-5950 NN denotes bud
T3345 5957-5958 -LRB- denotes (
T3346 5965-5967 NN denotes 1A
T3347 5958-5964 NN denotes Figure
T3348 5967-5968 -RRB- denotes )
T3349 5968-5969 . denotes .
T3350 5969-6081 sentence denotes As judged by immunohistochemistry, Snail protein was localized to the nuclei of the hair bud cells (Figure 1E).
T3351 5970-5972 IN denotes As
T3352 5973-5979 VBN denotes judged
T3353 6023-6032 VBN denotes localized
T3354 5980-5982 IN denotes by
T3355 5983-6003 NN denotes immunohistochemistry
T3356 6003-6005 , denotes ,
T3357 6005-6010 NN denotes Snail
T3358 6011-6018 NN denotes protein
T3359 6019-6022 VBD denotes was
T3360 6033-6035 IN denotes to
T3361 6036-6039 DT denotes the
T3362 6040-6046 NNS denotes nuclei
T3363 6047-6049 IN denotes of
T3364 6050-6053 DT denotes the
T3365 6063-6068 NNS denotes cells
T3366 6054-6058 NN denotes hair
T3367 6059-6062 NN denotes bud
T3368 6069-6070 -LRB- denotes (
T3369 6077-6079 NN denotes 1E
T3370 6070-6076 NN denotes Figure
T3371 6079-6080 -RRB- denotes )
T3372 6080-6081 . denotes .
T3373 6081-6177 sentence denotes This feature was consistent with Snail's known function as a transcriptional repressor [12,13].
T3374 6082-6086 DT denotes This
T3375 6087-6094 NN denotes feature
T3376 6095-6098 VBD denotes was
T3377 6099-6109 JJ denotes consistent
T3378 6110-6114 IN denotes with
T3379 6115-6120 NN denotes Snail
T3380 6129-6137 NN denotes function
T3381 6120-6122 POS denotes 's
T3382 6123-6128 VBN denotes known
T3383 6138-6140 IN denotes as
T3384 6141-6142 DT denotes a
T3385 6159-6168 NN denotes repressor
T3386 6143-6158 JJ denotes transcriptional
T3387 6169-6170 -LRB- denotes [
T3388 6173-6175 CD denotes 13
T3389 6170-6172 CD denotes 12
T3390 6172-6173 , denotes ,
T3391 6175-6176 -RRB- denotes ]
T3392 6176-6177 . denotes .
T3393 6177-6289 sentence denotes Additionally, anti-Snail labeling was detected in only three of the four major waves of follicle morphogenesis.
T3394 6178-6190 RB denotes Additionally
T3395 6216-6224 VBN denotes detected
T3396 6190-6192 , denotes ,
T3397 6192-6202 JJ denotes anti-Snail
T3398 6203-6211 NN denotes labeling
T3399 6212-6215 VBD denotes was
T3400 6225-6227 IN denotes in
T3401 6228-6232 RB denotes only
T3402 6246-6250 CD denotes four
T3403 6233-6238 CD denotes three
T3404 6239-6241 IN denotes of
T3405 6242-6245 DT denotes the
T3406 6257-6262 NNS denotes waves
T3407 6251-6256 JJ denotes major
T3408 6263-6265 IN denotes of
T3409 6266-6274 NN denotes follicle
T3410 6275-6288 NN denotes morphogenesis
T3411 6288-6289 . denotes .
T3412 6289-6463 sentence denotes Snail was not found in the buds of guard hairs that are the earliest of all hairs to form (at E13.5), and which constitute less than 5% of the mouse coat (unpublished data).
T3413 6290-6295 NN denotes Snail
T3414 6304-6309 VBN denotes found
T3415 6296-6299 VBD denotes was
T3416 6300-6303 RB denotes not
T3417 6310-6312 IN denotes in
T3418 6313-6316 DT denotes the
T3419 6317-6321 NNS denotes buds
T3420 6322-6324 IN denotes of
T3421 6325-6330 NN denotes guard
T3422 6331-6336 NNS denotes hairs
T3423 6337-6341 WDT denotes that
T3424 6342-6345 VBP denotes are
T3425 6346-6349 DT denotes the
T3426 6350-6358 JJS denotes earliest
T3427 6359-6361 IN denotes of
T3428 6362-6365 DT denotes all
T3429 6366-6371 NNS denotes hairs
T3430 6372-6374 TO denotes to
T3431 6375-6379 VB denotes form
T3432 6380-6381 -LRB- denotes (
T3433 6381-6383 IN denotes at
T3434 6384-6389 NN denotes E13.5
T3435 6389-6390 -RRB- denotes )
T3436 6390-6392 , denotes ,
T3437 6392-6395 CC denotes and
T3438 6396-6401 WDT denotes which
T3439 6402-6412 VBP denotes constitute
T3440 6413-6417 JJR denotes less
T3441 6423-6424 CD denotes 5
T3442 6418-6422 IN denotes than
T3443 6424-6425 NN denotes %
T3444 6426-6428 IN denotes of
T3445 6429-6432 DT denotes the
T3446 6439-6443 NN denotes coat
T3447 6433-6438 NN denotes mouse
T3448 6444-6445 -LRB- denotes (
T3449 6457-6461 NNS denotes data
T3450 6445-6456 JJ denotes unpublished
T3451 6461-6462 -RRB- denotes )
T3452 6462-6463 . denotes .
T3453 6463-6704 sentence denotes As judged by immunofluorescence with antibodies against the proliferating nuclear antigen Ki67, the timing of Snail expression coincided with the stage at which the developing follicle enhanced its proliferation and down-growth (Figure 1F).
T3454 6464-6466 IN denotes As
T3455 6467-6473 VBN denotes judged
T3456 6591-6600 VBD denotes coincided
T3457 6474-6476 IN denotes by
T3458 6477-6495 NN denotes immunofluorescence
T3459 6496-6500 IN denotes with
T3460 6501-6511 NNS denotes antibodies
T3461 6512-6519 IN denotes against
T3462 6520-6523 DT denotes the
T3463 6546-6553 NN denotes antigen
T3464 6524-6537 VBG denotes proliferating
T3465 6538-6545 JJ denotes nuclear
T3466 6554-6558 NN denotes Ki67
T3467 6558-6560 , denotes ,
T3468 6560-6563 DT denotes the
T3469 6564-6570 NN denotes timing
T3470 6571-6573 IN denotes of
T3471 6574-6579 NN denotes Snail
T3472 6580-6590 NN denotes expression
T3473 6601-6605 IN denotes with
T3474 6606-6609 DT denotes the
T3475 6610-6615 NN denotes stage
T3476 6616-6618 IN denotes at
T3477 6649-6657 VBD denotes enhanced
T3478 6619-6624 WDT denotes which
T3479 6625-6628 DT denotes the
T3480 6640-6648 NN denotes follicle
T3481 6629-6639 VBG denotes developing
T3482 6658-6661 PRP$ denotes its
T3483 6662-6675 NN denotes proliferation
T3484 6676-6679 CC denotes and
T3485 6680-6684 JJ denotes down
T3486 6685-6691 NN denotes growth
T3487 6684-6685 HYPH denotes -
T3488 6692-6693 -LRB- denotes (
T3489 6700-6702 NN denotes 1F
T3490 6693-6699 NN denotes Figure
T3491 6702-6703 -RRB- denotes )
T3492 6703-6704 . denotes .
T3493 6704-6926 sentence denotes Immunohistochemistry with antibodies against the active (phosphorylated) form of MAPK (pMAPK) marked a subset of the proliferating (Ki67-positive) cells, and pMAPK-positive cells were enriched in the hair bud (Figure 1G).
T3494 6705-6725 NN denotes Immunohistochemistry
T3495 6799-6805 VBD denotes marked
T3496 6726-6730 IN denotes with
T3497 6731-6741 NNS denotes antibodies
T3498 6742-6749 IN denotes against
T3499 6750-6753 DT denotes the
T3500 6778-6782 NN denotes form
T3501 6754-6760 JJ denotes active
T3502 6761-6762 -LRB- denotes (
T3503 6762-6776 VBN denotes phosphorylated
T3504 6776-6777 -RRB- denotes )
T3505 6783-6785 IN denotes of
T3506 6786-6790 NN denotes MAPK
T3507 6791-6792 -LRB- denotes (
T3508 6792-6797 NN denotes pMAPK
T3509 6797-6798 -RRB- denotes )
T3510 6806-6807 DT denotes a
T3511 6808-6814 NN denotes subset
T3512 6815-6817 IN denotes of
T3513 6818-6821 DT denotes the
T3514 6852-6857 NNS denotes cells
T3515 6822-6835 VBG denotes proliferating
T3516 6836-6837 -LRB- denotes (
T3517 6837-6841 NN denotes Ki67
T3518 6842-6850 JJ denotes positive
T3519 6841-6842 HYPH denotes -
T3520 6850-6851 -RRB- denotes )
T3521 6857-6859 , denotes ,
T3522 6859-6862 CC denotes and
T3523 6863-6868 NN denotes pMAPK
T3524 6869-6877 JJ denotes positive
T3525 6868-6869 HYPH denotes -
T3526 6878-6883 NNS denotes cells
T3527 6889-6897 VBN denotes enriched
T3528 6884-6888 VBD denotes were
T3529 6898-6900 IN denotes in
T3530 6901-6904 DT denotes the
T3531 6910-6913 NN denotes bud
T3532 6905-6909 NN denotes hair
T3533 6914-6915 -LRB- denotes (
T3534 6922-6924 NN denotes 1G
T3535 6915-6921 NN denotes Figure
T3536 6924-6925 -RRB- denotes )
T3537 6925-6926 . denotes .
T3538 6926-7122 sentence denotes The timing of Snail induction and Ki67 and pMAPK enrichment in the hair bud appeared to follow closely the induction of LEF-1/β-catenin activity, known to initiate in the hair placode stage [20].
T3539 6927-6930 DT denotes The
T3540 6931-6937 NN denotes timing
T3541 7003-7011 VBD denotes appeared
T3542 6938-6940 IN denotes of
T3543 6941-6946 NN denotes Snail
T3544 6947-6956 NN denotes induction
T3545 6957-6960 CC denotes and
T3546 6961-6965 NN denotes Ki67
T3547 6976-6986 NN denotes enrichment
T3548 6966-6969 CC denotes and
T3549 6970-6975 NN denotes pMAPK
T3550 6987-6989 IN denotes in
T3551 6990-6993 DT denotes the
T3552 6999-7002 NN denotes bud
T3553 6994-6998 NN denotes hair
T3554 7012-7014 TO denotes to
T3555 7015-7021 VB denotes follow
T3556 7022-7029 RB denotes closely
T3557 7030-7033 DT denotes the
T3558 7034-7043 NN denotes induction
T3559 7044-7046 IN denotes of
T3560 7047-7050 NN denotes LEF
T3561 7063-7071 NN denotes activity
T3562 7050-7051 HYPH denotes -
T3563 7051-7052 CD denotes 1
T3564 7052-7053 HYPH denotes /
T3565 7053-7054 NN denotes β
T3566 7055-7062 NN denotes catenin
T3567 7054-7055 HYPH denotes -
T3568 7071-7073 , denotes ,
T3569 7073-7078 VBN denotes known
T3570 7079-7081 TO denotes to
T3571 7082-7090 VB denotes initiate
T3572 7091-7093 IN denotes in
T3573 7094-7097 DT denotes the
T3574 7111-7116 NN denotes stage
T3575 7098-7102 NN denotes hair
T3576 7103-7110 NN denotes placode
T3577 7117-7118 -LRB- denotes [
T3578 7118-7120 CD denotes 20
T3579 7120-7121 -RRB- denotes ]
T3580 7121-7122 . denotes .
T3581 7122-7234 sentence denotes However, like placodes, hair buds exhibited down-regulation in E-cadherin expression (Figure 1H; see also [4]).
T3582 7123-7130 RB denotes However
T3583 7157-7166 VBD denotes exhibited
T3584 7130-7132 , denotes ,
T3585 7132-7136 IN denotes like
T3586 7137-7145 NNS denotes placodes
T3587 7145-7147 , denotes ,
T3588 7147-7151 NN denotes hair
T3589 7152-7156 NNS denotes buds
T3590 7167-7171 JJ denotes down
T3591 7172-7182 NN denotes regulation
T3592 7171-7172 HYPH denotes -
T3593 7183-7185 IN denotes in
T3594 7186-7187 NN denotes E
T3595 7188-7196 NN denotes cadherin
T3596 7187-7188 HYPH denotes -
T3597 7197-7207 NN denotes expression
T3598 7208-7209 -LRB- denotes (
T3599 7216-7218 NN denotes 1H
T3600 7209-7215 NN denotes Figure
T3601 7218-7219 : denotes ;
T3602 7220-7223 VB denotes see
T3603 7224-7228 RB denotes also
T3604 7229-7230 -LRB- denotes [
T3605 7230-7231 CD denotes 4
T3606 7231-7232 -RRB- denotes ]
T3607 7232-7233 -RRB- denotes )
T3608 7233-7234 . denotes .
R1433 T2702 T2703 compound Snail,mRNA
R1434 T2703 T2704 nsubjpass mRNA,Expressed
R1435 T2705 T2703 cc and,mRNA
R1436 T2706 T2703 conj Protein,mRNA
R1437 T2707 T2704 auxpass Are,Expressed
R1438 T2708 T2704 advmod Transiently,Expressed
R1439 T2709 T2704 prep at,Expressed
R1440 T2710 T2711 det the,Stage
R1441 T2711 T2709 pobj Stage,at
R1442 T2712 T2713 compound Hair,Bud
R1443 T2713 T2711 compound Bud,Stage
R1444 T2714 T2711 prep of,Stage
R1445 T2715 T2716 compound Follicle,Morphogenesis
R1446 T2716 T2714 pobj Morphogenesis,of
R1447 T2718 T2719 mark Although,associated
R1448 T2719 T2726 advcl associated,participate
R1449 T2720 T2721 compound Snail,members
R1450 T2721 T2719 nsubjpass members,associated
R1451 T2722 T2721 compound family,members
R1452 T2723 T2719 auxpass are,associated
R1453 T2724 T2725 advmod most,frequently
R1454 T2725 T2719 advmod frequently,associated
R1455 T2727 T2719 prep with,associated
R1456 T2728 T2727 pobj EMTs,with
R1457 T2729 T2726 punct ", ",participate
R1458 T2730 T2726 nsubj they,participate
R1459 T2731 T2726 advmod also,participate
R1460 T2732 T2726 prep in,participate
R1461 T2733 T2734 amod many,processes
R1462 T2734 T2732 pobj processes,in
R1463 T2735 T2734 amod malignant,processes
R1464 T2736 T2734 acl involving,processes
R1465 T2737 T2738 det a,regulation
R1466 T2738 T2736 dobj regulation,involving
R1467 T2739 T2738 amod down,regulation
R1468 T2740 T2738 punct -,regulation
R1469 T2741 T2738 cc but,regulation
R1470 T2742 T2741 neg not,but
R1471 T2743 T2744 det a,abrogation
R1472 T2744 T2738 conj abrogation,regulation
R1473 T2745 T2744 amod quantitative,abrogation
R1474 T2746 T2738 prep of,regulation
R1475 T2747 T2748 amod intercellular,junctions
R1476 T2748 T2746 pobj junctions,of
R1477 T2749 T2750 punct [,18
R1478 T2750 T2726 parataxis 18,participate
R1479 T2751 T2750 punct ],18
R1480 T2752 T2726 punct .,participate
R1481 T2754 T2755 det The,range
R1482 T2755 T2756 nsubj range,includes
R1483 T2757 T2755 prep of,range
R1484 T2758 T2759 amod developmental,processes
R1485 T2759 T2757 pobj processes,of
R1486 T2760 T2761 prep in,implicated
R1487 T2761 T2759 relcl implicated,processes
R1488 T2762 T2760 pobj which,in
R1489 T2763 T2764 compound Snail,members
R1490 T2764 T2761 nsubjpass members,implicated
R1491 T2765 T2764 compound family,members
R1492 T2766 T2761 aux have,implicated
R1493 T2767 T2761 auxpass been,implicated
R1494 T2768 T2756 advmod thus,includes
R1495 T2769 T2770 det the,type
R1496 T2770 T2756 dobj type,includes
R1497 T2771 T2770 prep of,type
R1498 T2772 T2773 amod epithelial,remodeling
R1499 T2773 T2771 pobj remodeling,of
R1500 T2774 T2775 dep that,observed
R1501 T2775 T2770 relcl observed,type
R1502 T2776 T2775 auxpass is,observed
R1503 T2777 T2775 prep in,observed
R1504 T2778 T2779 compound hair,follicle
R1505 T2779 T2780 compound follicle,bud
R1506 T2780 T2781 compound bud,formation
R1507 T2781 T2777 pobj formation,in
R1508 T2782 T2756 punct .,includes
R1509 T2784 T2785 prep Given,turned
R1510 T2786 T2787 poss our,observation
R1511 T2787 T2784 pobj observation,Given
R1512 T2788 T2787 amod prior,observation
R1513 T2789 T2790 mark that,participate
R1514 T2790 T2787 acl participate,observation
R1515 T2791 T2792 advmod exogenously,added
R1516 T2792 T2793 amod added,Snail
R1517 T2793 T2790 nsubj Snail,participate
R1518 T2794 T2790 aux can,participate
R1519 T2795 T2790 prep with,participate
R1520 T2796 T2795 pobj LEF,with
R1521 T2797 T2796 punct -,LEF
R1522 T2798 T2796 nummod 1,LEF
R1523 T2799 T2796 punct /,LEF
R1524 T2800 T2801 compound β,catenin
R1525 T2801 T2796 appos catenin,LEF
R1526 T2802 T2801 punct -,catenin
R1527 T2803 T2790 prep in,participate
R1528 T2804 T2805 advmod down,regulating
R1529 T2805 T2803 pcomp regulating,in
R1530 T2806 T2805 punct -,regulating
R1531 T2807 T2808 compound E,cadherin
R1532 T2808 T2810 compound cadherin,expression
R1533 T2809 T2808 punct -,cadherin
R1534 T2810 T2805 dobj expression,regulating
R1535 T2811 T2790 prep in,participate
R1536 T2812 T2811 pobj keratinocytes,in
R1537 T2813 T2814 punct [,4
R1538 T2814 T2790 parataxis 4,participate
R1539 T2815 T2814 punct ],4
R1540 T2816 T2787 punct ", ",observation
R1541 T2817 T2787 acl coupled,observation
R1542 T2818 T2817 prep with,coupled
R1543 T2819 T2820 det the,requirement
R1544 T2820 T2818 pobj requirement,with
R1545 T2821 T2820 amod established,requirement
R1546 T2822 T2820 prep for,requirement
R1547 T2823 T2822 pobj LEF,for
R1548 T2824 T2823 punct -,LEF
R1549 T2825 T2823 nummod 1,LEF
R1550 T2826 T2823 punct /,LEF
R1551 T2827 T2828 compound β,catenin
R1552 T2828 T2823 appos catenin,LEF
R1553 T2829 T2828 punct -,catenin
R1554 T2830 T2820 prep in,requirement
R1555 T2831 T2832 compound hair,follicle
R1556 T2832 T2833 compound follicle,morphogenesis
R1557 T2833 T2830 pobj morphogenesis,in
R1558 T2834 T2835 punct [,19
R1559 T2835 T2817 parataxis 19,coupled
R1560 T2836 T2835 nummod 4,19
R1561 T2837 T2835 punct ",",19
R1562 T2838 T2835 punct ],19
R1563 T2839 T2785 punct ", ",turned
R1564 T2840 T2785 nsubj we,turned
R1565 T2841 T2785 prep to,turned
R1566 T2842 T2841 pcomp addressing,to
R1567 T2843 T2844 mark whether,participate
R1568 T2844 T2842 ccomp participate,addressing
R1569 T2845 T2846 compound Snail,Slug
R1570 T2846 T2848 compound Slug,members
R1571 T2847 T2846 punct /,Slug
R1572 T2848 T2844 nsubj members,participate
R1573 T2849 T2848 compound family,members
R1574 T2850 T2844 aux might,participate
R1575 T2851 T2844 advmod also,participate
R1576 T2852 T2844 prep in,participate
R1577 T2853 T2854 det the,process
R1578 T2854 T2852 pobj process,in
R1579 T2855 T2785 punct .,turned
R1580 T2857 T2858 compound PCR,analyses
R1581 T2858 T2859 nsubj analyses,identified
R1582 T2860 T2861 amod transient,expression
R1583 T2861 T2859 dobj expression,identified
R1584 T2862 T2861 compound Snail,expression
R1585 T2863 T2861 compound mRNA,expression
R1586 T2864 T2859 prep during,identified
R1587 T2865 T2866 det a,period
R1588 T2866 T2864 pobj period,during
R1589 T2867 T2866 prep of,period
R1590 T2868 T2869 compound skin,embryogenesis
R1591 T2869 T2867 pobj embryogenesis,of
R1592 T2870 T2871 advmod when,forming
R1593 T2871 T2866 advcl forming,period
R1594 T2872 T2871 nsubj waves,forming
R1595 T2873 T2872 prep of,waves
R1596 T2874 T2875 compound hair,follicles
R1597 T2875 T2873 pobj follicles,of
R1598 T2876 T2871 aux are,forming
R1599 T2877 T2878 punct (,data
R1600 T2878 T2859 meta data,identified
R1601 T2879 T2878 amod unpublished,data
R1602 T2880 T2878 punct ),data
R1603 T2881 T2859 punct .,identified
R1604 T2882 T2883 aux To,pinpoint
R1605 T2883 T2885 advcl pinpoint,conducted
R1606 T2886 T2883 advmod specifically,pinpoint
R1607 T2887 T2888 advmod where,expressed
R1608 T2888 T2883 advcl expressed,pinpoint
R1609 T2889 T2890 compound Snail,mRNA
R1610 T2890 T2888 nsubjpass mRNA,expressed
R1611 T2891 T2888 auxpass is,expressed
R1612 T2892 T2888 prep in,expressed
R1613 T2893 T2894 det the,skin
R1614 T2894 T2892 pobj skin,in
R1615 T2895 T2894 amod developing,skin
R1616 T2896 T2885 punct ", ",conducted
R1617 T2897 T2885 nsubj we,conducted
R1618 T2898 T2899 advmod in,situ
R1619 T2899 T2900 amod situ,hybridization
R1620 T2900 T2885 dobj hybridization,conducted
R1621 T2901 T2885 advcl using,conducted
R1622 T2902 T2903 det a,probe
R1623 T2903 T2901 dobj probe,using
R1624 T2904 T2903 compound cRNA,probe
R1625 T2905 T2903 amod unique,probe
R1626 T2906 T2905 prep to,unique
R1627 T2907 T2908 det the,region
R1628 T2908 T2906 pobj region,to
R1629 T2909 T2908 nmod Snail,region
R1630 T2910 T2908 nummod 3,region
R1631 T2911 T2910 punct ′,3
R1632 T2912 T2908 amod untranslated,region
R1633 T2913 T2908 punct (,region
R1634 T2914 T2908 appos UTR,region
R1635 T2915 T2908 punct ),region
R1636 T2916 T2885 punct .,conducted
R1637 T2918 T2919 amod Embryonic,day
R1638 T2919 T2920 nsubjpass day,chosen
R1639 T2921 T2919 nummod 17.5,day
R1640 T2922 T2919 punct (,day
R1641 T2923 T2919 appos E17.5,day
R1642 T2924 T2920 punct ),chosen
R1643 T2925 T2920 auxpass was,chosen
R1644 T2926 T2920 punct ", ",chosen
R1645 T2927 T2928 mark since,enabled
R1646 T2928 T2920 advcl enabled,chosen
R1647 T2929 T2930 det the,waves
R1648 T2930 T2928 nsubj waves,enabled
R1649 T2931 T2930 amod multiple,waves
R1650 T2932 T2930 prep of,waves
R1651 T2933 T2934 compound follicle,morphogenesis
R1652 T2934 T2932 pobj morphogenesis,of
R1653 T2935 T2930 acl occurring,waves
R1654 T2936 T2935 prep at,occurring
R1655 T2937 T2938 det this,time
R1656 T2938 T2936 pobj time,at
R1657 T2939 T2928 dobj us,enabled
R1658 T2940 T2941 aux to,evaluate
R1659 T2941 T2928 xcomp evaluate,enabled
R1660 T2942 T2943 compound Snail,expression
R1661 T2943 T2941 dobj expression,evaluate
R1662 T2944 T2941 prep at,evaluate
R1663 T2945 T2946 amod different,stages
R1664 T2946 T2944 pobj stages,at
R1665 T2947 T2946 prep of,stages
R1666 T2948 T2949 det the,process
R1667 T2949 T2947 pobj process,of
R1668 T2950 T2920 punct .,chosen
R1669 T2952 T2953 mark As,shown
R1670 T2953 T2954 advcl shown,detected
R1671 T2955 T2953 prep in,shown
R1672 T2956 T2957 compound Figure,1A
R1673 T2957 T2955 pobj 1A,in
R1674 T2958 T2954 punct ", ",detected
R1675 T2959 T2960 amod specific,hybridization
R1676 T2960 T2954 nsubjpass hybridization,detected
R1677 T2961 T2954 auxpass was,detected
R1678 T2962 T2954 prep within,detected
R1679 T2963 T2964 det the,epithelium
R1680 T2964 T2962 pobj epithelium,within
R1681 T2965 T2964 prep of,epithelium
R1682 T2966 T2967 amod nascent,buds
R1683 T2967 T2965 pobj buds,of
R1684 T2968 T2967 compound hair,buds
R1685 T2969 T2954 punct .,detected
R1686 T2971 T2972 prep By,exhibited
R1687 T2973 T2971 pobj contrast,By
R1688 T2974 T2972 punct ", ",exhibited
R1689 T2975 T2976 mark as,progressed
R1690 T2976 T2972 advcl progressed,exhibited
R1691 T2977 T2976 nsubj follicles,progressed
R1692 T2978 T2976 advmod further,progressed
R1693 T2979 T2976 prep through,progressed
R1694 T2980 T2981 poss their,development
R1695 T2981 T2979 pobj development,through
R1696 T2982 T2983 punct (,stages
R1697 T2983 T2976 parataxis stages,progressed
R1698 T2984 T2983 advmod e.g.,stages
R1699 T2985 T2983 punct ", ",stages
R1700 T2986 T2983 nmod germ,stages
R1701 T2987 T2986 cc and,germ
R1702 T2988 T2986 conj peg,germ
R1703 T2989 T2983 punct ),stages
R1704 T2990 T2972 punct ", ",exhibited
R1705 T2991 T2972 nsubj they,exhibited
R1706 T2992 T2993 det no,signs
R1707 T2993 T2972 dobj signs,exhibited
R1708 T2994 T2993 prep of,signs
R1709 T2995 T2994 pobj hybridization,of
R1710 T2996 T2997 punct (,1A
R1711 T2997 T2972 parataxis 1A,exhibited
R1712 T2998 T2997 compound Figure,1A
R1713 T2999 T2997 punct ),1A
R1714 T3000 T2972 punct .,exhibited
R1715 T3002 T3003 det The,nature
R1716 T3003 T3005 nsubj nature,was
R1717 T3004 T3003 amod transient,nature
R1718 T3006 T3003 prep of,nature
R1719 T3007 T3008 compound Snail,expression
R1720 T3008 T3006 pobj expression,of
R1721 T3009 T3008 compound mRNA,expression
R1722 T3010 T3008 prep during,expression
R1723 T3011 T3012 compound follicle,development
R1724 T3012 T3010 pobj development,during
R1725 T3013 T3014 advmod most,apparent
R1726 T3014 T3005 acomp apparent,was
R1727 T3015 T3005 prep in,was
R1728 T3016 T3017 amod hybridized,sections
R1729 T3017 T3015 pobj sections,in
R1730 T3018 T3017 compound skin,sections
R1731 T3019 T3017 acl containing,sections
R1732 T3020 T3019 dobj follicles,containing
R1733 T3021 T3020 prep from,follicles
R1734 T3022 T3023 nummod two,waves
R1735 T3023 T3021 pobj waves,from
R1736 T3024 T3023 amod different,waves
R1737 T3025 T3023 prep of,waves
R1738 T3026 T3025 pobj morphogenesis,of
R1739 T3027 T3028 punct (,shown
R1740 T3028 T3005 parataxis shown,was
R1741 T3029 T3028 mark as,shown
R1742 T3030 T3028 prep in,shown
R1743 T3031 T3030 pobj Figure,in
R1744 T3032 T3031 nummod 1,Figure
R1745 T3033 T3028 punct ),shown
R1746 T3034 T3005 punct .,was
R1747 T3036 T3037 amod Hybridizing,buds
R1748 T3037 T3039 nsubj buds,appeared
R1749 T3038 T3037 compound hair,buds
R1750 T3040 T3037 prep from,buds
R1751 T3041 T3042 det a,wave
R1752 T3042 T3040 pobj wave,from
R1753 T3043 T3042 amod later,wave
R1754 T3044 T3039 oprd juxtaposed,appeared
R1755 T3045 T3044 prep with,juxtaposed
R1756 T3046 T3047 amod nonhybridizing,follicles
R1757 T3047 T3045 pobj follicles,with
R1758 T3048 T3047 prep from,follicles
R1759 T3049 T3050 det an,wave
R1760 T3050 T3048 pobj wave,from
R1761 T3051 T3050 amod earlier,wave
R1762 T3052 T3039 punct .,appeared
R1763 T3054 T3055 aux To,determine
R1764 T3055 T3056 advcl determine,generated
R1765 T3057 T3058 mark whether,reflected
R1766 T3058 T3055 ccomp reflected,determine
R1767 T3059 T3060 det this,nature
R1768 T3060 T3058 nsubjpass nature,reflected
R1769 T3061 T3060 amod transient,nature
R1770 T3062 T3060 prep of,nature
R1771 T3063 T3064 compound Snail,expression
R1772 T3064 T3062 pobj expression,of
R1773 T3065 T3064 compound mRNA,expression
R1774 T3066 T3058 auxpass is,reflected
R1775 T3067 T3058 prep at,reflected
R1776 T3068 T3069 det the,level
R1777 T3069 T3067 pobj level,at
R1778 T3070 T3069 compound protein,level
R1779 T3071 T3056 punct ", ",generated
R1780 T3072 T3056 nsubj we,generated
R1781 T3073 T3074 det an,antibody
R1782 T3074 T3056 dobj antibody,generated
R1783 T3075 T3074 prep against,antibody
R1784 T3076 T3077 det the,sequence
R1785 T3077 T3075 pobj sequence,against
R1786 T3078 T3079 npadvmod N,terminal
R1787 T3079 T3077 amod terminal,sequence
R1788 T3080 T3079 punct -,terminal
R1789 T3081 T3082 dep that,resides
R1790 T3082 T3077 relcl resides,sequence
R1791 T3083 T3082 advmod upstream,resides
R1792 T3084 T3083 prep of,upstream
R1793 T3085 T3086 det the,domains
R1794 T3086 T3084 pobj domains,of
R1795 T3087 T3088 advmod more,conserved
R1796 T3088 T3086 amod conserved,domains
R1797 T3089 T3090 compound zinc,finger
R1798 T3090 T3086 compound finger,domains
R1799 T3091 T3056 punct .,generated
R1800 T3093 T3094 mark As,judged
R1801 T3094 T3095 advcl judged,detect
R1802 T3096 T3094 prep by,judged
R1803 T3097 T3098 compound Western,blot
R1804 T3098 T3099 compound blot,analysis
R1805 T3099 T3096 pobj analysis,by
R1806 T3100 T3095 punct ", ",detect
R1807 T3101 T3102 det the,antibody
R1808 T3102 T3095 nsubj antibody,detect
R1809 T3103 T3095 aux did,detect
R1810 T3104 T3095 neg not,detect
R1811 T3105 T3106 amod endogenous,proteins
R1812 T3106 T3095 dobj proteins,detect
R1813 T3107 T3106 prep from,proteins
R1814 T3108 T3109 amod cultured,keratinocytes
R1815 T3109 T3107 pobj keratinocytes,from
R1816 T3110 T3095 punct ", ",detect
R1817 T3111 T3095 cc but,detect
R1818 T3112 T3113 nsubj it,yield
R1819 T3113 T3095 conj yield,detect
R1820 T3114 T3113 aux did,yield
R1821 T3115 T3116 det a,band
R1822 T3116 T3113 dobj band,yield
R1823 T3117 T3116 prep of,band
R1824 T3118 T3119 det the,size
R1825 T3119 T3117 pobj size,of
R1826 T3120 T3119 amod expected,size
R1827 T3121 T3113 prep from,yield
R1828 T3122 T3121 pobj keratinocytes,from
R1829 T3123 T3124 advmod transiently,expressing
R1830 T3124 T3122 acl expressing,keratinocytes
R1831 T3125 T3126 det a,protein
R1832 T3126 T3124 dobj protein,expressing
R1833 T3127 T3128 npadvmod hemagglutinin,tagged
R1834 T3128 T3126 amod tagged,protein
R1835 T3129 T3127 punct (,hemagglutinin
R1836 T3130 T3127 appos HA,hemagglutinin
R1837 T3131 T3128 punct ),tagged
R1838 T3132 T3128 punct -,tagged
R1839 T3133 T3126 compound Snail,protein
R1840 T3134 T3135 punct (,1B
R1841 T3135 T3113 parataxis 1B,yield
R1842 T3136 T3135 compound Figure,1B
R1843 T3137 T3135 punct ),1B
R1844 T3138 T3095 punct .,detect
R1845 T3140 T3141 det The,antibody
R1846 T3141 T3142 nsubj antibody,recognized
R1847 T3143 T3142 advmod also,recognized
R1848 T3144 T3145 det a,band
R1849 T3145 T3142 dobj band,recognized
R1850 T3146 T3145 acl corresponding,band
R1851 T3147 T3146 prep to,corresponding
R1852 T3148 T3149 det the,size
R1853 T3149 T3147 pobj size,to
R1854 T3150 T3149 prep of,size
R1855 T3151 T3152 amod endogenous,Snail
R1856 T3152 T3150 pobj Snail,of
R1857 T3153 T3149 punct (,size
R1858 T3154 T3155 advmod approximately,28
R1859 T3155 T3156 nummod 28,kDa
R1860 T3156 T3149 appos kDa,size
R1861 T3157 T3149 punct ),size
R1862 T3158 T3149 prep in,size
R1863 T3159 T3158 pobj lysates,in
R1864 T3160 T3159 prep from,lysates
R1865 T3161 T3162 amod embryonic,skin
R1866 T3162 T3160 pobj skin,from
R1867 T3163 T3162 compound mouse,skin
R1868 T3164 T3145 punct ", ",band
R1869 T3165 T3166 det the,appearance
R1870 T3166 T3168 dep appearance,corresponded
R1871 T3167 T3166 amod temporal,appearance
R1872 T3168 T3145 relcl corresponded,band
R1873 T3169 T3166 prep of,appearance
R1874 T3170 T3169 pobj which,of
R1875 T3171 T3168 prep to,corresponded
R1876 T3172 T3173 det the,waves
R1877 T3173 T3171 pobj waves,to
R1878 T3174 T3173 prep of,waves
R1879 T3175 T3176 compound hair,follicle
R1880 T3176 T3177 compound follicle,morphogenesis
R1881 T3177 T3174 pobj morphogenesis,of
R1882 T3178 T3173 prep from,waves
R1883 T3179 T3178 pobj E15.5,from
R1884 T3180 T3178 prep to,from
R1885 T3181 T3180 amod newborn,to
R1886 T3182 T3183 advmod when,formed
R1887 T3183 T3173 relcl formed,waves
R1888 T3184 T3185 quantmod over,90
R1889 T3185 T3186 nummod 90,%
R1890 T3186 T3183 nsubjpass %,formed
R1891 T3187 T3186 prep of,%
R1892 T3188 T3189 det the,hair
R1893 T3189 T3187 pobj hair,of
R1894 T3190 T3189 prep on,hair
R1895 T3191 T3192 det the,mouse
R1896 T3192 T3190 pobj mouse,on
R1897 T3193 T3183 auxpass is,formed
R1898 T3194 T3195 punct (,1B
R1899 T3195 T3142 parataxis 1B,recognized
R1900 T3196 T3195 compound Figure,1B
R1901 T3197 T3195 punct ),1B
R1902 T3198 T3142 punct .,recognized
R1903 T3200 T3201 advcl Consistent,detect
R1904 T3202 T3200 prep with,Consistent
R1905 T3203 T3204 det the,data
R1906 T3204 T3202 pobj data,with
R1907 T3205 T3206 compound Western,blot
R1908 T3206 T3204 compound blot,data
R1909 T3207 T3201 punct ", ",detect
R1910 T3208 T3209 amod immunohistochemical,analysis
R1911 T3209 T3201 nsubj analysis,detect
R1912 T3210 T3201 aux did,detect
R1913 T3211 T3201 neg not,detect
R1914 T3212 T3201 dobj Snail,detect
R1915 T3213 T3201 prep in,detect
R1916 T3214 T3215 amod single,layered
R1917 T3215 T3217 amod layered,epidermis
R1918 T3216 T3215 punct -,layered
R1919 T3217 T3213 pobj epidermis,in
R1920 T3218 T3217 compound E13.5,epidermis
R1921 T3219 T3220 punct (,1C
R1922 T3220 T3217 parataxis 1C,epidermis
R1923 T3221 T3220 compound Figure,1C
R1924 T3222 T3220 punct ),1C
R1925 T3223 T3213 cc nor,in
R1926 T3224 T3213 conj in,in
R1927 T3225 T3226 det the,placode
R1928 T3226 T3224 pobj placode,in
R1929 T3227 T3201 punct ", ",detect
R1930 T3228 T3229 dep which,is
R1931 T3229 T3201 advcl is,detect
R1932 T3230 T3231 det the,sign
R1933 T3231 T3229 attr sign,is
R1934 T3232 T3231 amod earliest,sign
R1935 T3233 T3231 amod morphological,sign
R1936 T3234 T3231 prep of,sign
R1937 T3235 T3236 det the,commitment
R1938 T3236 T3234 pobj commitment,of
R1939 T3237 T3236 prep of,commitment
R1940 T3238 T3239 amod multipotent,cells
R1941 T3239 T3237 pobj cells,of
R1942 T3240 T3239 prep of,cells
R1943 T3241 T3242 det the,ectoderm
R1944 T3242 T3240 pobj ectoderm,of
R1945 T3243 T3242 amod embryonic,ectoderm
R1946 T3244 T3236 prep to,commitment
R1947 T3245 T3246 det a,fate
R1948 T3246 T3244 pobj fate,to
R1949 T3247 T3248 compound hair,cell
R1950 T3248 T3246 compound cell,fate
R1951 T3249 T3250 punct (,1D
R1952 T3250 T3201 parataxis 1D,detect
R1953 T3251 T3250 compound Figure,1D
R1954 T3252 T3250 punct ),1D
R1955 T3253 T3201 punct .,detect
R1956 T3255 T3256 advcl Consistent,labeled
R1957 T3257 T3255 prep with,Consistent
R1958 T3258 T3259 det the,results
R1959 T3259 T3257 pobj results,with
R1960 T3260 T3261 advmod in,situ
R1961 T3261 T3259 amod situ,results
R1962 T3262 T3259 compound hybridization,results
R1963 T3263 T3256 punct ", ",labeled
R1964 T3264 T3265 amod anti-Snail,antibody
R1965 T3265 T3256 nsubj antibody,labeled
R1966 T3266 T3267 advmod only,buds
R1967 T3267 T3256 dobj buds,labeled
R1968 T3268 T3267 compound hair,buds
R1969 T3269 T3267 cc and,buds
R1970 T3270 T3269 neg not,and
R1971 T3271 T3267 conj follicles,buds
R1972 T3272 T3256 prep at,labeled
R1973 T3273 T3274 advmod more,stages
R1974 T3274 T3272 pobj stages,at
R1975 T3275 T3274 amod mature,stages
R1976 T3276 T3274 prep of,stages
R1977 T3277 T3276 pobj development,of
R1978 T3278 T3279 punct (,1E
R1979 T3279 T3256 parataxis 1E,labeled
R1980 T3280 T3279 compound Figure,1E
R1981 T3281 T3279 punct ),1E
R1982 T3282 T3256 punct .,labeled
R1983 T3284 T3285 advcl Taken,appeared
R1984 T3286 T3284 advmod together,Taken
R1985 T3287 T3285 punct ", ",appeared
R1986 T3288 T3289 det the,antibody
R1987 T3289 T3285 nsubj antibody,appeared
R1988 T3290 T3289 amod anti-Snail,antibody
R1989 T3291 T3292 aux to,be
R1990 T3292 T3285 xcomp be,appeared
R1991 T3293 T3292 acomp specific,be
R1992 T3294 T3293 prep for,specific
R1993 T3295 T3296 poss its,protein
R1994 T3296 T3294 pobj protein,for
R1995 T3297 T3296 compound target,protein
R1996 T3298 T3285 punct .,appeared
R1997 T3300 T3301 nsubj It,detect
R1998 T3302 T3301 aux did,detect
R1999 T3303 T3301 neg not,detect
R2000 T3304 T3305 amod other,members
R2001 T3305 T3301 dobj members,detect
R2002 T3306 T3305 compound Snail,members
R2003 T3307 T3305 compound family,members
R2004 T3308 T3305 acl known,members
R2005 T3309 T3310 aux to,expressed
R2006 T3310 T3308 xcomp expressed,known
R2007 T3311 T3310 auxpass be,expressed
R2008 T3312 T3310 prep in,expressed
R2009 T3313 T3312 pobj keratinocytes,in
R2010 T3314 T3313 cc and,keratinocytes
R2011 T3315 T3314 punct /,and
R2012 T3316 T3314 cc or,and
R2013 T3317 T3313 conj skin,keratinocytes
R2014 T3318 T3319 punct (,data
R2015 T3319 T3308 meta data,known
R2016 T3320 T3319 amod unpublished,data
R2017 T3321 T3319 punct ),data
R2018 T3322 T3301 punct .,detect
R2019 T3324 T3325 advmod Furthermore,paralleled
R2020 T3326 T3325 punct ", ",paralleled
R2021 T3327 T3328 det the,data
R2022 T3328 T3325 nsubj data,paralleled
R2023 T3329 T3328 amod immunohistochemical,data
R2024 T3330 T3331 poss our,data
R2025 T3331 T3325 dobj data,paralleled
R2026 T3332 T3333 nmod Snail,hybridization
R2027 T3333 T3331 compound hybridization,data
R2028 T3334 T3335 advmod in,situ
R2029 T3335 T3333 amod situ,hybridization
R2030 T3336 T3325 advcl revealing,paralleled
R2031 T3337 T3338 amod transient,expression
R2032 T3338 T3336 dobj expression,revealing
R2033 T3339 T3338 compound Snail,expression
R2034 T3340 T3336 prep at,revealing
R2035 T3341 T3342 det the,stage
R2036 T3342 T3340 pobj stage,at
R2037 T3343 T3344 compound hair,bud
R2038 T3344 T3342 compound bud,stage
R2039 T3345 T3346 punct (,1A
R2040 T3346 T3325 parataxis 1A,paralleled
R2041 T3347 T3346 compound Figure,1A
R2042 T3348 T3346 punct ),1A
R2043 T3349 T3325 punct .,paralleled
R2044 T3351 T3352 mark As,judged
R2045 T3352 T3353 advcl judged,localized
R2046 T3354 T3352 prep by,judged
R2047 T3355 T3354 pobj immunohistochemistry,by
R2048 T3356 T3353 punct ", ",localized
R2049 T3357 T3358 compound Snail,protein
R2050 T3358 T3353 nsubjpass protein,localized
R2051 T3359 T3353 auxpass was,localized
R2052 T3360 T3353 prep to,localized
R2053 T3361 T3362 det the,nuclei
R2054 T3362 T3360 pobj nuclei,to
R2055 T3363 T3362 prep of,nuclei
R2056 T3364 T3365 det the,cells
R2057 T3365 T3363 pobj cells,of
R2058 T3366 T3367 compound hair,bud
R2059 T3367 T3365 compound bud,cells
R2060 T3368 T3369 punct (,1E
R2061 T3369 T3353 parataxis 1E,localized
R2062 T3370 T3369 compound Figure,1E
R2063 T3371 T3369 punct ),1E
R2064 T3372 T3353 punct .,localized
R2065 T3374 T3375 det This,feature
R2066 T3375 T3376 nsubj feature,was
R2067 T3377 T3376 acomp consistent,was
R2068 T3378 T3377 prep with,consistent
R2069 T3379 T3380 poss Snail,function
R2070 T3380 T3378 pobj function,with
R2071 T3381 T3379 case 's,Snail
R2072 T3382 T3380 amod known,function
R2073 T3383 T3380 prep as,function
R2074 T3384 T3385 det a,repressor
R2075 T3385 T3383 pobj repressor,as
R2076 T3386 T3385 amod transcriptional,repressor
R2077 T3387 T3388 punct [,13
R2078 T3388 T3376 parataxis 13,was
R2079 T3389 T3388 nummod 12,13
R2080 T3390 T3388 punct ",",13
R2081 T3391 T3388 punct ],13
R2082 T3392 T3376 punct .,was
R2083 T3394 T3395 advmod Additionally,detected
R2084 T3396 T3395 punct ", ",detected
R2085 T3397 T3398 amod anti-Snail,labeling
R2086 T3398 T3395 nsubjpass labeling,detected
R2087 T3399 T3395 auxpass was,detected
R2088 T3400 T3395 prep in,detected
R2089 T3401 T3402 advmod only,four
R2090 T3402 T3406 nummod four,waves
R2091 T3403 T3402 quantmod three,four
R2092 T3404 T3402 quantmod of,four
R2093 T3405 T3402 quantmod the,four
R2094 T3406 T3400 pobj waves,in
R2095 T3407 T3406 amod major,waves
R2096 T3408 T3406 prep of,waves
R2097 T3409 T3410 compound follicle,morphogenesis
R2098 T3410 T3408 pobj morphogenesis,of
R2099 T3411 T3395 punct .,detected
R2100 T3413 T3414 nsubjpass Snail,found
R2101 T3415 T3414 auxpass was,found
R2102 T3416 T3414 neg not,found
R2103 T3417 T3414 prep in,found
R2104 T3418 T3419 det the,buds
R2105 T3419 T3417 pobj buds,in
R2106 T3420 T3419 prep of,buds
R2107 T3421 T3422 compound guard,hairs
R2108 T3422 T3420 pobj hairs,of
R2109 T3423 T3424 dep that,are
R2110 T3424 T3422 advcl are,hairs
R2111 T3425 T3426 det the,earliest
R2112 T3426 T3424 attr earliest,are
R2113 T3427 T3426 prep of,earliest
R2114 T3428 T3429 det all,hairs
R2115 T3429 T3427 pobj hairs,of
R2116 T3430 T3431 aux to,form
R2117 T3431 T3429 advcl form,hairs
R2118 T3432 T3433 punct (,at
R2119 T3433 T3426 parataxis at,earliest
R2120 T3434 T3433 pobj E13.5,at
R2121 T3435 T3433 punct ),at
R2122 T3436 T3424 punct ", ",are
R2123 T3437 T3424 cc and,are
R2124 T3438 T3439 dep which,constitute
R2125 T3439 T3424 conj constitute,are
R2126 T3440 T3441 amod less,5
R2127 T3441 T3443 nummod 5,%
R2128 T3442 T3441 quantmod than,5
R2129 T3443 T3439 dobj %,constitute
R2130 T3444 T3443 prep of,%
R2131 T3445 T3446 det the,coat
R2132 T3446 T3444 pobj coat,of
R2133 T3447 T3446 compound mouse,coat
R2134 T3448 T3449 punct (,data
R2135 T3449 T3414 meta data,found
R2136 T3450 T3449 amod unpublished,data
R2137 T3451 T3449 punct ),data
R2138 T3452 T3414 punct .,found
R2139 T3454 T3455 mark As,judged
R2140 T3455 T3456 advcl judged,coincided
R2141 T3457 T3455 prep by,judged
R2142 T3458 T3457 pobj immunofluorescence,by
R2143 T3459 T3458 prep with,immunofluorescence
R2144 T3460 T3459 pobj antibodies,with
R2145 T3461 T3460 prep against,antibodies
R2146 T3462 T3463 det the,antigen
R2147 T3463 T3461 pobj antigen,against
R2148 T3464 T3463 amod proliferating,antigen
R2149 T3465 T3463 amod nuclear,antigen
R2150 T3466 T3463 appos Ki67,antigen
R2151 T3467 T3456 punct ", ",coincided
R2152 T3468 T3469 det the,timing
R2153 T3469 T3456 nsubj timing,coincided
R2154 T3470 T3469 prep of,timing
R2155 T3471 T3472 compound Snail,expression
R2156 T3472 T3470 pobj expression,of
R2157 T3473 T3456 prep with,coincided
R2158 T3474 T3475 det the,stage
R2159 T3475 T3473 pobj stage,with
R2160 T3476 T3477 prep at,enhanced
R2161 T3477 T3475 relcl enhanced,stage
R2162 T3478 T3476 pobj which,at
R2163 T3479 T3480 det the,follicle
R2164 T3480 T3477 nsubj follicle,enhanced
R2165 T3481 T3480 amod developing,follicle
R2166 T3482 T3483 poss its,proliferation
R2167 T3483 T3477 dobj proliferation,enhanced
R2168 T3484 T3483 cc and,proliferation
R2169 T3485 T3486 amod down,growth
R2170 T3486 T3483 conj growth,proliferation
R2171 T3487 T3486 punct -,growth
R2172 T3488 T3489 punct (,1F
R2173 T3489 T3456 parataxis 1F,coincided
R2174 T3490 T3489 compound Figure,1F
R2175 T3491 T3489 punct ),1F
R2176 T3492 T3456 punct .,coincided
R2177 T3494 T3495 nsubj Immunohistochemistry,marked
R2178 T3496 T3494 prep with,Immunohistochemistry
R2179 T3497 T3496 pobj antibodies,with
R2180 T3498 T3497 prep against,antibodies
R2181 T3499 T3500 det the,form
R2182 T3500 T3498 pobj form,against
R2183 T3501 T3500 amod active,form
R2184 T3502 T3500 punct (,form
R2185 T3503 T3500 amod phosphorylated,form
R2186 T3504 T3500 punct ),form
R2187 T3505 T3500 prep of,form
R2188 T3506 T3505 pobj MAPK,of
R2189 T3507 T3500 punct (,form
R2190 T3508 T3500 appos pMAPK,form
R2191 T3509 T3495 punct ),marked
R2192 T3510 T3511 det a,subset
R2193 T3511 T3495 dobj subset,marked
R2194 T3512 T3511 prep of,subset
R2195 T3513 T3514 det the,cells
R2196 T3514 T3512 pobj cells,of
R2197 T3601 T3599 punct ;,1H
R2198 T3515 T3514 amod proliferating,cells
R2199 T3602 T3599 advcl see,1H
R2200 T3516 T3514 punct (,cells
R2201 T3603 T3602 advmod also,see
R2202 T3604 T3602 punct [,see
R2203 T3517 T3518 npadvmod Ki67,positive
R2204 T3605 T3602 dobj 4,see
R2205 T3606 T3599 punct ],1H
R2206 T3607 T3599 punct ),1H
R2207 T3518 T3514 amod positive,cells
R2208 T3608 T3583 punct .,exhibited
R2209 T3519 T3518 punct -,positive
R2210 T3520 T3514 punct ),cells
R2211 T3521 T3495 punct ", ",marked
R2212 T3522 T3495 cc and,marked
R2213 T3523 T3524 npadvmod pMAPK,positive
R2214 T3524 T3526 amod positive,cells
R2215 T3525 T3524 punct -,positive
R2216 T3526 T3527 nsubjpass cells,enriched
R2217 T3527 T3495 conj enriched,marked
R2218 T3528 T3527 auxpass were,enriched
R2219 T3529 T3527 prep in,enriched
R2220 T3530 T3531 det the,bud
R2221 T3531 T3529 pobj bud,in
R2222 T3532 T3531 compound hair,bud
R2223 T3533 T3534 punct (,1G
R2224 T3534 T3527 parataxis 1G,enriched
R2225 T3535 T3534 compound Figure,1G
R2226 T3536 T3534 punct ),1G
R2227 T3537 T3527 punct .,enriched
R2228 T3539 T3540 det The,timing
R2229 T3540 T3541 nsubj timing,appeared
R2230 T3542 T3540 prep of,timing
R2231 T3543 T3544 compound Snail,induction
R2232 T3544 T3542 pobj induction,of
R2233 T3545 T3544 cc and,induction
R2234 T3546 T3547 nmod Ki67,enrichment
R2235 T3547 T3544 conj enrichment,induction
R2236 T3548 T3546 cc and,Ki67
R2237 T3549 T3546 conj pMAPK,Ki67
R2238 T3550 T3540 prep in,timing
R2239 T3551 T3552 det the,bud
R2240 T3552 T3550 pobj bud,in
R2241 T3553 T3552 compound hair,bud
R2242 T3554 T3555 aux to,follow
R2243 T3555 T3541 xcomp follow,appeared
R2244 T3556 T3555 advmod closely,follow
R2245 T3557 T3558 det the,induction
R2246 T3558 T3555 dobj induction,follow
R2247 T3559 T3558 prep of,induction
R2248 T3560 T3561 nmod LEF,activity
R2249 T3561 T3559 pobj activity,of
R2250 T3562 T3560 punct -,LEF
R2251 T3563 T3560 nummod 1,LEF
R2252 T3564 T3560 punct /,LEF
R2253 T3565 T3566 compound β,catenin
R2254 T3566 T3560 appos catenin,LEF
R2255 T3567 T3566 punct -,catenin
R2256 T3568 T3561 punct ", ",activity
R2257 T3569 T3561 acl known,activity
R2258 T3570 T3571 aux to,initiate
R2259 T3571 T3569 xcomp initiate,known
R2260 T3572 T3571 prep in,initiate
R2261 T3573 T3574 det the,stage
R2262 T3574 T3572 pobj stage,in
R2263 T3575 T3576 compound hair,placode
R2264 T3576 T3574 compound placode,stage
R2265 T3577 T3578 punct [,20
R2266 T3578 T3555 parataxis 20,follow
R2267 T3579 T3578 punct ],20
R2268 T3580 T3541 punct .,appeared
R2269 T3582 T3583 advmod However,exhibited
R2270 T3584 T3583 punct ", ",exhibited
R2271 T3585 T3583 prep like,exhibited
R2272 T3586 T3585 pobj placodes,like
R2273 T3587 T3583 punct ", ",exhibited
R2274 T3588 T3589 compound hair,buds
R2275 T3589 T3583 nsubj buds,exhibited
R2276 T3590 T3591 amod down,regulation
R2277 T3591 T3583 dobj regulation,exhibited
R2278 T3592 T3591 punct -,regulation
R2279 T3593 T3591 prep in,regulation
R2280 T3594 T3595 compound E,cadherin
R2281 T3595 T3597 compound cadherin,expression
R2282 T3596 T3595 punct -,cadherin
R2283 T3597 T3593 pobj expression,in
R2284 T3598 T3599 punct (,1H
R2285 T3599 T3583 parataxis 1H,exhibited
R2286 T3600 T3599 compound Figure,1H