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PMC:539061 / 7562-8693 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T717 53-58 PR:000015308 denotes Snail
T718 66-70 UBERON:0001037 denotes hair
T719 126-139 GO:0016055 denotes Wnt signaling
T720 144-147 PR:000000034 denotes BMP
T721 160-165 PR:000009751 denotes LEF-1
T722 166-175 PR:000002198 denotes β-catenin
T723 213-218 PR:000015308 denotes Snail
T724 219-223 SO:0000704 denotes gene
T725 219-234 GO:0010467 denotes gene expression
T726 238-247 UBERON:0000922 denotes embryonic
T727 253-266 CL:0000312 denotes keratinocytes
T728 323-327 SO:0000704 denotes gene
T729 360-366 PR:000000183 denotes TGF-β2
T730 371-441 PR:000000364 denotes small phenotype– and mothers against decapentaplegic–related protein 2
T731 443-448 PR:000000364 denotes SMAD2
T732 485-490 PR:000015308 denotes Snail
T733 491-495 SO:0000704 denotes gene
T734 491-506 GO:0010467 denotes gene expression
T735 510-525 UBERON:0019204 denotes skin epithelium
T736 545-551 PR:000000183 denotes TGF-β2
T737 566-571 PR:000015308 denotes Snail
T738 572-576 SO:0000704 denotes gene
T739 572-587 GO:0010467 denotes gene expression
T740 589-602 UBERON:0005086 denotes hair placodes
T741 693-698 PR:000015308 denotes Snail
T742 730-753 GO:0001708 denotes cell fate specification
T743 807-820 GO:0008283 denotes proliferation
T2400 846-851 PR:000015308 denotes Snail
T2401 873-882 GO:0010467 denotes Expressed
T2402 902-906 UBERON:0001037 denotes Hair
T2403 929-942 GO:0009653 denotes Morphogenesis
T2404 952-957 PR:000015308 denotes Snail
T2405 1009-1013 GO:0001837 denotes EMTs

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T980 5-20 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T981 53-58 PR_EXT:000015308 denotes Snail
T982 66-70 UBERON:0001037 denotes hair
T983 95-99 CHEBI_SO_EXT:mRNA denotes mRNA
T984 126-139 GO:0016055 denotes Wnt signaling
T985 144-147 PR_EXT:000000034 denotes BMP
T986 160-165 PR_EXT:000009751 denotes LEF-1
T987 166-175 PR_EXT:000002198 denotes β-catenin
T988 213-218 PR_EXT:000015308 denotes Snail
T989 219-223 SO_EXT:0000704 denotes gene
T990 219-234 GO:0010467 denotes gene expression
T991 238-247 UBERON:0000922 denotes embryonic
T992 248-252 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T993 253-266 CL:0000312 denotes keratinocytes
T994 302-312 SO_EXT:transgenic_entity denotes transgenic
T995 314-316 SO_EXT:transgenic_entity denotes Tg
T996 323-327 SO_EXT:0000704 denotes gene
T997 360-366 PR_EXT:000000183 denotes TGF-β2
T998 371-441 PR_EXT:000000364 denotes small phenotype– and mothers against decapentaplegic–related protein 2
T999 432-439 CHEBI_PR_EXT:protein denotes protein
T1000 443-448 PR_EXT:000000364 denotes SMAD2
T1001 450-459 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T1002 485-490 PR_EXT:000015308 denotes Snail
T1003 491-495 SO_EXT:0000704 denotes gene
T1004 491-506 GO:0010467 denotes gene expression
T1005 510-525 UBERON:0019204 denotes skin epithelium
T1006 545-551 PR_EXT:000000183 denotes TGF-β2
T1007 552-561 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T1008 566-571 PR_EXT:000015308 denotes Snail
T1009 572-576 SO_EXT:0000704 denotes gene
T1010 572-587 GO:0010467 denotes gene expression
T1011 589-602 UBERON:0005086 denotes hair placodes
T1012 625-633 UBERON_EXT:follicle denotes follicle
T1013 639-645 GO_EXT:biological_growth_entity_or_process denotes growth
T1014 693-698 PR_EXT:000015308 denotes Snail
T1015 730-734 CL_GO_EXT:cell denotes cell
T1016 730-753 GO:0001708 denotes cell fate specification
T1017 807-820 GO:0008283 denotes proliferation
T1018 825-834 GO_EXT:biological_movement_or_translocation_process denotes migration
T2526 846-851 PR_EXT:000015308 denotes Snail
T2527 852-856 CHEBI_SO_EXT:mRNA denotes mRNA
T2528 861-868 CHEBI_PR_EXT:protein denotes Protein
T2529 873-882 GO:0010467 denotes Expressed
T2530 902-906 UBERON:0001037 denotes Hair
T2531 920-928 UBERON_EXT:follicle denotes Follicle
T2532 929-942 GO:0009653 denotes Morphogenesis
T2533 952-957 PR_EXT:000015308 denotes Snail
T2534 1009-1013 GO:0001837 denotes EMTs
T2535 1077-1092 GO_EXT:negative_regulation denotes down-regulation

craft-sa-dev

Id Subject Object Predicate Lexical cue
T2117 5-20 NN denotes differentiation
T2119 20-21 . denotes .
T2120 21-267 sentence denotes Although the temporal spike of Snail in the hair bud is reflected at the mRNA level and seems to follow Wnt signaling and BMP inhibition, LEF-1/β-catenin activation does not appear to induce Snail gene expression in embryonic skin keratinocytes.
T2121 22-30 IN denotes Although
T2122 78-87 VBN denotes reflected
T2123 31-34 DT denotes the
T2124 44-49 NN denotes spike
T2125 35-43 JJ denotes temporal
T2126 50-52 IN denotes of
T2127 53-58 NN denotes Snail
T2128 59-61 IN denotes in
T2129 62-65 DT denotes the
T2130 71-74 NN denotes bud
T2131 66-70 NN denotes hair
T2132 75-77 VBZ denotes is
T2133 196-202 VB denotes appear
T2134 88-90 IN denotes at
T2135 91-94 DT denotes the
T2136 100-105 NN denotes level
T2137 95-99 NN denotes mRNA
T2138 106-109 CC denotes and
T2139 110-115 VBZ denotes seems
T2140 116-118 TO denotes to
T2141 119-125 VB denotes follow
T2142 126-129 NN denotes Wnt
T2143 130-139 NN denotes signaling
T2144 140-143 CC denotes and
T2145 144-147 NN denotes BMP
T2146 148-158 NN denotes inhibition
T2147 158-160 , denotes ,
T2148 160-163 NN denotes LEF
T2149 176-186 NN denotes activation
T2150 163-164 HYPH denotes -
T2151 164-165 CD denotes 1
T2152 165-166 HYPH denotes /
T2153 166-167 NN denotes β
T2154 168-175 NN denotes catenin
T2155 167-168 HYPH denotes -
T2156 187-191 VBZ denotes does
T2157 192-195 RB denotes not
T2158 203-205 TO denotes to
T2159 206-212 VB denotes induce
T2160 213-218 NN denotes Snail
T2161 224-234 NN denotes expression
T2162 219-223 NN denotes gene
T2163 235-237 IN denotes in
T2164 238-247 JJ denotes embryonic
T2165 253-266 NNS denotes keratinocytes
T2166 248-252 NN denotes skin
T2167 266-267 . denotes .
T2168 267-526 sentence denotes In contrast, we provide in vitro, transgenic (Tg), and gene targeting evidence to show that TGF-β2 and small phenotype– and mothers against decapentaplegic–related protein 2 (SMAD2) signaling are upstream inducers of Snail gene expression in skin epithelium.
T2169 268-270 IN denotes In
T2170 284-291 VBP denotes provide
T2171 271-279 NN denotes contrast
T2172 279-281 , denotes ,
T2173 281-283 PRP denotes we
T2174 292-294 FW denotes in
T2175 295-300 FW denotes vitro
T2176 338-346 NN denotes evidence
T2177 300-302 , denotes ,
T2178 302-312 JJ denotes transgenic
T2179 313-314 -LRB- denotes (
T2180 314-316 JJ denotes Tg
T2181 316-317 -RRB- denotes )
T2182 317-319 , denotes ,
T2183 319-322 CC denotes and
T2184 323-327 NN denotes gene
T2185 328-337 VBG denotes targeting
T2186 347-349 TO denotes to
T2187 350-354 VB denotes show
T2188 355-359 IN denotes that
T2189 460-463 VBP denotes are
T2190 360-363 NN denotes TGF
T2191 364-366 NN denotes β2
T2192 363-364 HYPH denotes -
T2193 450-459 NN denotes signaling
T2194 367-370 CC denotes and
T2195 371-376 JJ denotes small
T2196 377-386 NN denotes phenotype
T2197 424-431 VBN denotes related
T2198 386-387 -LRB- denotes –
T2199 388-391 CC denotes and
T2200 392-399 NNS denotes mothers
T2201 400-407 IN denotes against
T2202 408-423 NN denotes decapentaplegic
T2203 423-424 -RRB- denotes –
T2204 432-439 NN denotes protein
T2205 440-441 CD denotes 2
T2206 442-443 -LRB- denotes (
T2207 443-448 NN denotes SMAD2
T2208 448-449 -RRB- denotes )
T2209 464-472 JJ denotes upstream
T2210 473-481 NNS denotes inducers
T2211 482-484 IN denotes of
T2212 485-490 NN denotes Snail
T2213 496-506 NN denotes expression
T2214 491-495 NN denotes gene
T2215 507-509 IN denotes in
T2216 510-514 NN denotes skin
T2217 515-525 NN denotes epithelium
T2218 525-526 . denotes .
T2219 526-657 sentence denotes In the absence of TGF-β2 signaling and Snail gene expression, hair placodes can form, but further follicle down-growth is blocked.
T2220 527-529 IN denotes In
T2221 607-611 VB denotes form
T2222 530-533 DT denotes the
T2223 534-541 NN denotes absence
T2224 542-544 IN denotes of
T2225 545-548 NN denotes TGF
T2226 549-551 NN denotes β2
T2227 548-549 HYPH denotes -
T2228 552-561 NN denotes signaling
T2229 562-565 CC denotes and
T2230 566-571 NN denotes Snail
T2231 577-587 NN denotes expression
T2232 572-576 NN denotes gene
T2233 587-589 , denotes ,
T2234 589-593 NN denotes hair
T2235 594-602 NNS denotes placodes
T2236 603-606 MD denotes can
T2237 611-613 , denotes ,
T2238 613-616 CC denotes but
T2239 617-624 JJ denotes further
T2240 639-645 NN denotes growth
T2241 625-633 NN denotes follicle
T2242 634-638 JJ denotes down
T2243 638-639 HYPH denotes -
T2244 649-656 VBN denotes blocked
T2245 646-648 VBZ denotes is
T2246 656-657 . denotes .
T2247 657-835 sentence denotes Our studies point to the view that Snail likely functions downstream of cell fate specification, at a stage where the bud begins to exhibit enhanced proliferation and migration.
T2248 658-661 PRP$ denotes Our
T2249 662-669 NNS denotes studies
T2250 670-675 VBP denotes point
T2251 676-678 IN denotes to
T2252 679-682 DT denotes the
T2253 683-687 NN denotes view
T2254 688-692 IN denotes that
T2255 706-715 VBZ denotes functions
T2256 693-698 NN denotes Snail
T2257 699-705 RB denotes likely
T2258 716-726 RB denotes downstream
T2259 727-729 IN denotes of
T2260 730-734 NN denotes cell
T2261 735-739 NN denotes fate
T2262 740-753 NN denotes specification
T2263 753-755 , denotes ,
T2264 755-757 IN denotes at
T2265 758-759 DT denotes a
T2266 760-765 NN denotes stage
T2267 766-771 WRB denotes where
T2268 780-786 VBZ denotes begins
T2269 772-775 DT denotes the
T2270 776-779 NN denotes bud
T2271 787-789 TO denotes to
T2272 790-797 VB denotes exhibit
T2273 798-806 VBN denotes enhanced
T2274 807-820 NN denotes proliferation
T2275 821-824 CC denotes and
T2276 825-834 NN denotes migration
T2277 834-835 . denotes .
T2702 846-851 NN denotes Snail
T2703 852-856 NN denotes mRNA
T2704 873-882 VBN denotes Expressed
T2705 857-860 CC denotes and
T2706 861-868 NN denotes Protein
T2707 869-872 VBP denotes Are
T2708 883-894 RB denotes Transiently
T2709 895-897 IN denotes at
T2710 898-901 DT denotes the
T2711 911-916 NN denotes Stage
T2712 902-906 NN denotes Hair
T2713 907-910 NN denotes Bud
T2714 917-919 IN denotes of
T2715 920-928 NN denotes Follicle
T2716 929-942 NN denotes Morphogenesis
T2718 943-951 IN denotes Although
T2719 993-1003 VBN denotes associated
T2720 952-957 NN denotes Snail
T2721 965-972 NNS denotes members
T2722 958-964 NN denotes family
T2723 973-976 VBP denotes are
T2724 977-981 RBS denotes most
T2725 982-992 RB denotes frequently
T2726 1025-1036 VBP denotes participate
T2727 1004-1008 IN denotes with
T2728 1009-1013 NNS denotes EMTs
T2729 1013-1015 , denotes ,
T2730 1015-1019 PRP denotes they
T2731 1020-1024 RB denotes also
T2732 1037-1039 IN denotes in
T2733 1040-1044 JJ denotes many
T2734 1055-1064 NNS denotes processes
T2735 1045-1054 JJ denotes malignant
T2736 1065-1074 VBG denotes involving
T2737 1075-1076 DT denotes a
T2738 1082-1092 NN denotes regulation
T2739 1077-1081 JJ denotes down
T2740 1081-1082 HYPH denotes -
T2741 1093-1096 CC denotes but
T2742 1097-1100 RB denotes not
T2743 1101-1102 DT denotes a
T2744 1116-1126 NN denotes abrogation
T2745 1103-1115 JJ denotes quantitative
T2746 1127-1129 IN denotes of
R1208 T2121 T2122 mark Although,reflected
R1210 T2122 T2133 advcl reflected,appear
R1211 T2123 T2124 det the,spike
R1213 T2124 T2122 nsubjpass spike,reflected
R1214 T2125 T2124 amod temporal,spike
R1216 T2126 T2124 prep of,spike
R1217 T2127 T2126 pobj Snail,of
R1219 T2128 T2124 prep in,spike
R1220 T2129 T2130 det the,bud
R1221 T2130 T2128 pobj bud,in
R1223 T2131 T2130 compound hair,bud
R1224 T2132 T2122 auxpass is,reflected
R1226 T2134 T2122 prep at,reflected
R1227 T2135 T2136 det the,level
R1228 T2136 T2134 pobj level,at
R1230 T2137 T2136 compound mRNA,level
R1231 T2138 T2122 cc and,reflected
R1232 T2139 T2122 conj seems,reflected
R1234 T2140 T2141 aux to,follow
R1235 T2141 T2139 xcomp follow,seems
R1236 T2142 T2143 compound Wnt,signaling
R1238 T2143 T2141 dobj signaling,follow
R1239 T2144 T2143 cc and,signaling
R1241 T2145 T2146 compound BMP,inhibition
R1242 T2146 T2143 conj inhibition,signaling
R1243 T2147 T2133 punct ", ",appear
R1245 T2148 T2149 nmod LEF,activation
R1246 T2149 T2133 nsubj activation,appear
R1248 T2150 T2148 punct -,LEF
R1249 T2151 T2148 nummod 1,LEF
R1250 T2152 T2148 punct /,LEF
R1252 T2153 T2154 compound β,catenin
R1253 T2154 T2148 appos catenin,LEF
R1254 T2155 T2154 punct -,catenin
R1256 T2156 T2133 aux does,appear
R1257 T2157 T2133 neg not,appear
R1258 T2158 T2159 aux to,induce
R1259 T2159 T2133 xcomp induce,appear
R1260 T2160 T2161 compound Snail,expression
R1261 T2161 T2159 dobj expression,induce
R1262 T2162 T2161 compound gene,expression
R1264 T2163 T2159 prep in,induce
R1265 T2164 T2165 amod embryonic,keratinocytes
R1266 T2165 T2163 pobj keratinocytes,in
R1267 T2166 T2165 compound skin,keratinocytes
R1269 T2167 T2133 punct .,appear
R1271 T2169 T2170 prep In,provide
R1272 T2171 T2169 pobj contrast,In
R1274 T2172 T2170 punct ", ",provide
R1275 T2173 T2170 nsubj we,provide
R1276 T2174 T2175 advmod in,vitro
R1278 T2175 T2176 amod vitro,evidence
R1279 T2176 T2170 dobj evidence,provide
R1281 T2177 T2175 punct ", ",vitro
R1282 T2178 T2175 conj transgenic,vitro
R1283 T2179 T2180 punct (,Tg
R1285 T2180 T2178 parataxis Tg,transgenic
R1286 T2181 T2180 punct ),Tg
R1287 T2182 T2178 punct ", ",transgenic
R1289 T2183 T2178 cc and,transgenic
R1290 T2184 T2185 npadvmod gene,targeting
R1292 T2185 T2178 conj targeting,transgenic
R1293 T2186 T2187 aux to,show
R1295 T2187 T2170 advcl show,provide
R1296 T2188 T2189 mark that,are
R1299 T2189 T2187 ccomp are,show
R1300 T2190 T2191 nmod TGF,β2
R1302 T2191 T2193 nmod β2,signaling
R1303 T2192 T2191 punct -,β2
R1304 T2193 T2189 nsubj signaling,are
R1306 T2194 T2191 cc and,β2
R1307 T2195 T2196 amod small,phenotype
R1308 T2196 T2197 npadvmod phenotype,related
R1309 T2197 T2204 amod related,protein
R1310 T2198 T2196 punct –,phenotype
R1311 T2199 T2196 cc and,phenotype
R1313 T2200 T2196 conj mothers,phenotype
R1314 T2201 T2200 prep against,mothers
R1315 T2202 T2201 pobj decapentaplegic,against
R1318 T2203 T2197 punct –,related
R1319 T2204 T2191 conj protein,β2
R1321 T2205 T2204 nummod 2,protein
R1322 T2206 T2204 punct (,protein
R1323 T2207 T2204 appos SMAD2,protein
R1325 T2208 T2193 punct ),signaling
R1326 T2209 T2210 amod upstream,inducers
R1328 T2210 T2189 attr inducers,are
R1329 T2211 T2210 prep of,inducers
R1330 T2212 T2213 compound Snail,expression
R1332 T2213 T2211 pobj expression,of
R1333 T2214 T2213 compound gene,expression
R1335 T2215 T2189 prep in,are
R1336 T2216 T2217 compound skin,epithelium
R1338 T2217 T2215 pobj epithelium,in
R1339 T2218 T2170 punct .,provide
R1341 T2220 T2221 prep In,form
R1343 T2222 T2223 det the,absence
R1344 T2223 T2220 pobj absence,In
R1346 T2224 T2223 prep of,absence
R1347 T2225 T2226 compound TGF,β2
R1348 T2226 T2228 compound β2,signaling
R1350 T2227 T2226 punct -,β2
R1352 T2228 T2224 pobj signaling,of
R1353 T2229 T2228 cc and,signaling
R1354 T2230 T2231 compound Snail,expression
R1356 T2231 T2228 conj expression,signaling
R1357 T2232 T2231 compound gene,expression
R1359 T2233 T2221 punct ", ",form
R1360 T2234 T2235 compound hair,placodes
R1361 T2235 T2221 nsubj placodes,form
R1362 T2236 T2221 aux can,form
R1363 T2237 T2221 punct ", ",form
R1364 T2238 T2221 cc but,form
R1366 T2239 T2240 amod further,growth
R1367 T2240 T2244 nsubjpass growth,blocked
R1371 T2243 T2240 punct -,growth
R1372 T2244 T2221 conj blocked,form
R1373 T2245 T2244 auxpass is,blocked
R1375 T2246 T2221 punct .,form
R1377 T2248 T2249 poss Our,studies
R1378 T2249 T2250 nsubj studies,point
R1379 T2251 T2250 prep to,point
R1381 T2252 T2253 det the,view
R1382 T2253 T2251 pobj view,to
R1384 T2254 T2255 mark that,functions
R1385 T2255 T2253 acl functions,view
R1386 T2256 T2255 nsubj Snail,functions
R1388 T2257 T2255 advmod likely,functions
R1389 T2258 T2255 advmod downstream,functions
R1390 T2259 T2258 prep of,downstream
R1392 T2260 T2261 compound cell,fate
R1393 T2261 T2262 compound fate,specification
R1395 T2262 T2259 pobj specification,of
R1396 T2263 T2250 punct ", ",point
R1397 T2264 T2250 prep at,point
R1399 T2265 T2266 det a,stage
R1400 T2266 T2264 pobj stage,at
R1402 T2267 T2268 advmod where,begins
R1403 T2268 T2266 relcl begins,stage
R1405 T2269 T2270 det the,bud
R1406 T2270 T2268 nsubj bud,begins
R1408 T2271 T2272 aux to,exhibit
R1409 T2272 T2268 xcomp exhibit,begins
R1410 T2273 T2274 amod enhanced,proliferation
R1412 T2274 T2272 dobj proliferation,exhibit
R1413 T2275 T2274 cc and,proliferation
R1414 T2276 T2274 conj migration,proliferation
R1415 T2277 T2250 punct .,point
R1433 T2702 T2703 compound Snail,mRNA
R1434 T2703 T2704 nsubjpass mRNA,Expressed
R1435 T2705 T2703 cc and,mRNA
R1436 T2706 T2703 conj Protein,mRNA
R1437 T2707 T2704 auxpass Are,Expressed
R1438 T2708 T2704 advmod Transiently,Expressed
R1439 T2709 T2704 prep at,Expressed
R1440 T2710 T2711 det the,Stage
R1441 T2711 T2709 pobj Stage,at
R1442 T2712 T2713 compound Hair,Bud
R1443 T2713 T2711 compound Bud,Stage
R1444 T2714 T2711 prep of,Stage
R1445 T2715 T2716 compound Follicle,Morphogenesis
R1446 T2716 T2714 pobj Morphogenesis,of
R1447 T2718 T2719 mark Although,associated
R1448 T2719 T2726 advcl associated,participate
R1449 T2720 T2721 compound Snail,members
R1450 T2721 T2719 nsubjpass members,associated
R1451 T2722 T2721 compound family,members
R1452 T2723 T2719 auxpass are,associated
R1453 T2724 T2725 advmod most,frequently
R1454 T2725 T2719 advmod frequently,associated
R1455 T2727 T2719 prep with,associated
R1456 T2728 T2727 pobj EMTs,with
R1457 T2729 T2726 punct ", ",participate
R1458 T2730 T2726 nsubj they,participate
R1459 T2731 T2726 advmod also,participate
R1460 T2732 T2726 prep in,participate
R1461 T2733 T2734 amod many,processes
R1462 T2734 T2732 pobj processes,in
R1463 T2735 T2734 amod malignant,processes
R1464 T2736 T2734 acl involving,processes
R1465 T2737 T2738 det a,regulation
R1466 T2738 T2736 dobj regulation,involving
R1467 T2739 T2738 amod down,regulation
R1468 T2740 T2738 punct -,regulation
R1469 T2741 T2738 cc but,regulation
R1470 T2742 T2741 neg not,but
R1471 T2743 T2744 det a,abrogation
R1472 T2744 T2738 conj abrogation,regulation
R1473 T2745 T2744 amod quantitative,abrogation
R1474 T2746 T2738 prep of,regulation
R1368 T2241 T2240 nmod follicle,growth
R1369 T2242 T2240 amod down,growth