Id |
Subject |
Object |
Predicate |
Lexical cue |
T8900 |
0-10 |
RB |
denotes |
Previously |
T8901 |
14-26 |
VBD |
denotes |
demonstrated |
T8902 |
11-13 |
PRP |
denotes |
we |
T8903 |
27-31 |
IN |
denotes |
that |
T8904 |
101-109 |
VBN |
denotes |
required |
T8905 |
32-35 |
DT |
denotes |
the |
T8906 |
46-52 |
NN |
denotes |
action |
T8907 |
36-45 |
JJ |
denotes |
concerted |
T8908 |
53-55 |
IN |
denotes |
of |
T8909 |
56-59 |
DT |
denotes |
the |
T8910 |
74-81 |
NNS |
denotes |
signals |
T8911 |
60-73 |
JJ |
denotes |
extracellular |
T8912 |
82-85 |
NN |
denotes |
Wnt |
T8913 |
86-89 |
CC |
denotes |
and |
T8914 |
90-96 |
NN |
denotes |
noggin |
T8915 |
97-100 |
VBP |
denotes |
are |
T8916 |
110-113 |
IN |
denotes |
for |
T8917 |
175-182 |
VB |
denotes |
repress |
T8918 |
114-117 |
DT |
denotes |
the |
T8919 |
118-128 |
NN |
denotes |
generation |
T8920 |
129-131 |
IN |
denotes |
of |
T8921 |
132-133 |
DT |
denotes |
a |
T8922 |
164-171 |
NN |
denotes |
complex |
T8923 |
134-137 |
NN |
denotes |
LEF |
T8924 |
137-138 |
HYPH |
denotes |
- |
T8925 |
138-139 |
CD |
denotes |
1 |
T8926 |
139-140 |
HYPH |
denotes |
/ |
T8927 |
140-141 |
NN |
denotes |
β |
T8928 |
142-149 |
NN |
denotes |
catenin |
T8929 |
141-142 |
HYPH |
denotes |
- |
T8930 |
150-163 |
NN |
denotes |
transcription |
T8931 |
172-174 |
TO |
denotes |
to |
T8932 |
183-184 |
NN |
denotes |
E |
T8933 |
185-193 |
NN |
denotes |
cadherin |
T8934 |
184-185 |
HYPH |
denotes |
- |
T8935 |
194-207 |
NN |
denotes |
transcription |
T8936 |
208-210 |
IN |
denotes |
at |
T8937 |
211-214 |
DT |
denotes |
the |
T8938 |
215-220 |
NN |
denotes |
onset |
T8939 |
221-223 |
IN |
denotes |
of |
T8940 |
224-228 |
NN |
denotes |
hair |
T8941 |
229-233 |
NN |
denotes |
fate |
T8942 |
234-247 |
NN |
denotes |
specification |
T8943 |
247-248 |
. |
denotes |
. |
T8944 |
248-415 |
sentence |
denotes |
As shown in Figure 6I and 6J, both WT and TGF-β2 null buds exhibited nuclear LEF-1 and β-catenin localization, signs that the Wnt-noggin signaling pathway was intact. |
T8945 |
249-251 |
IN |
denotes |
As |
T8946 |
252-257 |
VBN |
denotes |
shown |
T8947 |
308-317 |
VBD |
denotes |
exhibited |
T8948 |
258-260 |
IN |
denotes |
in |
T8949 |
261-267 |
NN |
denotes |
Figure |
T8950 |
268-270 |
NN |
denotes |
6I |
T8951 |
271-274 |
CC |
denotes |
and |
T8952 |
275-277 |
NN |
denotes |
6J |
T8953 |
277-279 |
, |
denotes |
, |
T8954 |
279-283 |
CC |
denotes |
both |
T8955 |
284-286 |
NN |
denotes |
WT |
T8956 |
298-302 |
JJ |
denotes |
null |
T8957 |
287-290 |
CC |
denotes |
and |
T8958 |
291-294 |
NN |
denotes |
TGF |
T8959 |
295-297 |
NN |
denotes |
β2 |
T8960 |
294-295 |
HYPH |
denotes |
- |
T8961 |
303-307 |
NNS |
denotes |
buds |
T8962 |
318-325 |
JJ |
denotes |
nuclear |
T8963 |
346-358 |
NN |
denotes |
localization |
T8964 |
326-329 |
NN |
denotes |
LEF |
T8965 |
329-330 |
HYPH |
denotes |
- |
T8966 |
330-331 |
CD |
denotes |
1 |
T8967 |
332-335 |
CC |
denotes |
and |
T8968 |
336-337 |
NN |
denotes |
β |
T8969 |
338-345 |
NN |
denotes |
catenin |
T8970 |
337-338 |
HYPH |
denotes |
- |
T8971 |
358-360 |
, |
denotes |
, |
T8972 |
360-365 |
NNS |
denotes |
signs |
T8973 |
366-370 |
IN |
denotes |
that |
T8974 |
404-407 |
VBD |
denotes |
was |
T8975 |
371-374 |
DT |
denotes |
the |
T8976 |
396-403 |
NN |
denotes |
pathway |
T8977 |
375-378 |
NN |
denotes |
Wnt |
T8978 |
379-385 |
NN |
denotes |
noggin |
T8979 |
378-379 |
HYPH |
denotes |
- |
T8980 |
386-395 |
NN |
denotes |
signaling |
T8981 |
408-414 |
JJ |
denotes |
intact |
T9019 |
610-612 |
, |
denotes |
, |
T9020 |
612-615 |
NN |
denotes |
TGF |
T9021 |
616-618 |
NN |
denotes |
β2 |
T9022 |
615-616 |
HYPH |
denotes |
- |
T9023 |
627-629 |
TO |
denotes |
to |
T9024 |
630-634 |
VB |
denotes |
work |
T9025 |
635-637 |
IN |
denotes |
in |
T9026 |
638-644 |
NN |
denotes |
tandem |
T9027 |
645-649 |
IN |
denotes |
with |
T9028 |
650-655 |
DT |
denotes |
these |
T9029 |
662-672 |
NNS |
denotes |
morphogens |
T9030 |
656-661 |
JJ |
denotes |
other |
T9031 |
673-675 |
TO |
denotes |
to |
T9032 |
681-689 |
VB |
denotes |
regulate |
T9033 |
676-680 |
RB |
denotes |
down |
T9034 |
680-681 |
HYPH |
denotes |
- |
T9035 |
690-691 |
NN |
denotes |
E |
T9036 |
692-700 |
NN |
denotes |
cadherin |
T9037 |
691-692 |
HYPH |
denotes |
- |
T9038 |
701-707 |
NNS |
denotes |
levels |
T9039 |
707-709 |
, |
denotes |
, |
T9040 |
709-714 |
WDT |
denotes |
which |
T9041 |
715-726 |
VBZ |
denotes |
contributes |
T9042 |
727-729 |
IN |
denotes |
to |
T9043 |
730-733 |
DT |
denotes |
the |
T9044 |
734-744 |
NN |
denotes |
activation |
T9045 |
745-747 |
IN |
denotes |
of |
T9046 |
748-761 |
JJ |
denotes |
proliferative |
T9047 |
762-773 |
NNS |
denotes |
circuitries |
T9048 |
773-774 |
. |
denotes |
. |
T9016 |
589-594 |
NN |
denotes |
Snail |
T9017 |
600-610 |
NN |
denotes |
expression |
T9018 |
595-599 |
NN |
denotes |
gene |
T8982 |
414-415 |
. |
denotes |
. |
T8983 |
415-556 |
sentence |
denotes |
These data suggest that during hair follicle morphogenesis, TGF-β2 functions subsequently to Wnt/noggin-mediated determination of hair fate. |
T8984 |
416-421 |
DT |
denotes |
These |
T8985 |
422-426 |
NNS |
denotes |
data |
T8986 |
427-434 |
VBP |
denotes |
suggest |
T8987 |
435-439 |
IN |
denotes |
that |
T8988 |
483-492 |
VBZ |
denotes |
functions |
T8989 |
440-446 |
IN |
denotes |
during |
T8990 |
447-451 |
NN |
denotes |
hair |
T8991 |
452-460 |
NN |
denotes |
follicle |
T8992 |
461-474 |
NN |
denotes |
morphogenesis |
T8993 |
474-476 |
, |
denotes |
, |
T8994 |
476-479 |
NN |
denotes |
TGF |
T8995 |
480-482 |
NN |
denotes |
β2 |
T8996 |
479-480 |
HYPH |
denotes |
- |
T8997 |
493-505 |
RB |
denotes |
subsequently |
T8998 |
506-508 |
IN |
denotes |
to |
T8999 |
509-512 |
NN |
denotes |
Wnt |
T9000 |
513-519 |
NN |
denotes |
noggin |
T9001 |
512-513 |
HYPH |
denotes |
/ |
T9002 |
520-528 |
VBN |
denotes |
mediated |
T9003 |
519-520 |
HYPH |
denotes |
- |
T9004 |
529-542 |
NN |
denotes |
determination |
T9005 |
543-545 |
IN |
denotes |
of |
T9006 |
546-550 |
NN |
denotes |
hair |
T9007 |
551-555 |
NN |
denotes |
fate |
T9008 |
555-556 |
. |
denotes |
. |
T9009 |
556-774 |
sentence |
denotes |
Moreover, through activation of Snail gene expression, TGF-β2 appears to work in tandem with these other morphogens to down-regulate E-cadherin levels, which contributes to the activation of proliferative circuitries. |
T9010 |
557-565 |
RB |
denotes |
Moreover |
T9011 |
619-626 |
VBZ |
denotes |
appears |
T9012 |
565-567 |
, |
denotes |
, |
T9013 |
567-574 |
IN |
denotes |
through |
T9014 |
575-585 |
NN |
denotes |
activation |
T9015 |
586-588 |
IN |
denotes |
of |
R5602 |
T8900 |
T8901 |
advmod |
Previously,demonstrated |
R5604 |
T8902 |
T8901 |
nsubj |
we,demonstrated |
R5605 |
T8903 |
T8904 |
mark |
that,required |
R5607 |
T8904 |
T8901 |
ccomp |
required,demonstrated |
R5608 |
T8905 |
T8906 |
det |
the,action |
R5609 |
T8906 |
T8904 |
nsubjpass |
action,required |
R5610 |
T8907 |
T8906 |
amod |
concerted,action |
R5611 |
T8908 |
T8906 |
prep |
of,action |
R5613 |
T8909 |
T8910 |
det |
the,signals |
R5614 |
T8910 |
T8908 |
pobj |
signals,of |
R5615 |
T8911 |
T8910 |
amod |
extracellular,signals |
R5617 |
T8912 |
T8910 |
appos |
Wnt,signals |
R5618 |
T8913 |
T8912 |
cc |
and,Wnt |
R5619 |
T8914 |
T8912 |
conj |
noggin,Wnt |
R5621 |
T8915 |
T8904 |
auxpass |
are,required |
R5622 |
T8916 |
T8917 |
mark |
for,repress |
R5625 |
T8917 |
T8904 |
advcl |
repress,required |
R5626 |
T8918 |
T8919 |
det |
the,generation |
R5628 |
T8919 |
T8917 |
nsubj |
generation,repress |
R5629 |
T8920 |
T8919 |
prep |
of,generation |
R5630 |
T8921 |
T8922 |
det |
a,complex |
R5632 |
T8922 |
T8920 |
pobj |
complex,of |
R5633 |
T8923 |
T8922 |
nmod |
LEF,complex |
R5634 |
T8924 |
T8923 |
punct |
-,LEF |
R5636 |
T8925 |
T8923 |
nummod |
1,LEF |
R5637 |
T8926 |
T8923 |
punct |
/,LEF |
R5638 |
T8927 |
T8928 |
compound |
β,catenin |
R5640 |
T8928 |
T8923 |
appos |
catenin,LEF |
R5641 |
T8929 |
T8928 |
punct |
-,catenin |
R5643 |
T8930 |
T8922 |
compound |
transcription,complex |
R5644 |
T8931 |
T8917 |
aux |
to,repress |
R5645 |
T8932 |
T8933 |
compound |
E,cadherin |
R5647 |
T8933 |
T8935 |
compound |
cadherin,transcription |
R5648 |
T8934 |
T8933 |
punct |
-,cadherin |
R5650 |
T8935 |
T8917 |
dobj |
transcription,repress |
R5651 |
T8936 |
T8917 |
prep |
at,repress |
R5652 |
T8937 |
T8938 |
det |
the,onset |
R5654 |
T8938 |
T8936 |
pobj |
onset,at |
R5655 |
T8939 |
T8938 |
prep |
of,onset |
R5657 |
T8940 |
T8941 |
compound |
hair,fate |
R5658 |
T8941 |
T8942 |
compound |
fate,specification |
R5659 |
T8942 |
T8939 |
pobj |
specification,of |
R5660 |
T8943 |
T8901 |
punct |
.,demonstrated |
R5662 |
T8945 |
T8946 |
mark |
As,shown |
R5663 |
T8946 |
T8947 |
advcl |
shown,exhibited |
R5664 |
T8948 |
T8946 |
prep |
in,shown |
R5666 |
T8949 |
T8950 |
compound |
Figure,6I |
R5667 |
T8950 |
T8948 |
pobj |
6I,in |
R5669 |
T8951 |
T8950 |
cc |
and,6I |
R5670 |
T8952 |
T8950 |
conj |
6J,6I |
R5671 |
T8953 |
T8947 |
punct |
", ",exhibited |
R5673 |
T8954 |
T8955 |
preconj |
both,WT |
R5674 |
T8955 |
T8956 |
npadvmod |
WT,null |
R5676 |
T8956 |
T8961 |
amod |
null,buds |
R5677 |
T8957 |
T8955 |
cc |
and,WT |
R5678 |
T8958 |
T8959 |
compound |
TGF,β2 |
R5679 |
T8959 |
T8955 |
conj |
β2,WT |
R5680 |
T8960 |
T8959 |
punct |
-,β2 |
R5682 |
T8961 |
T8947 |
nsubj |
buds,exhibited |
R5683 |
T8962 |
T8963 |
amod |
nuclear,localization |
R5684 |
T8963 |
T8947 |
dobj |
localization,exhibited |
R5685 |
T8964 |
T8963 |
nmod |
LEF,localization |
R5687 |
T8965 |
T8964 |
punct |
-,LEF |
R5688 |
T8966 |
T8964 |
nummod |
1,LEF |
R5689 |
T8967 |
T8964 |
cc |
and,LEF |
R5691 |
T8968 |
T8969 |
compound |
β,catenin |
R5692 |
T8969 |
T8964 |
conj |
catenin,LEF |
R5693 |
T8970 |
T8969 |
punct |
-,catenin |
R5694 |
T8982 |
T8947 |
punct |
.,exhibited |
R5695 |
T8971 |
T8947 |
punct |
", ",exhibited |
R5696 |
T8972 |
T8947 |
npadvmod |
signs,exhibited |
R5697 |
T8973 |
T8974 |
mark |
that,was |
R5698 |
T8974 |
T8972 |
acl |
was,signs |
R5699 |
T8975 |
T8976 |
det |
the,pathway |
R5700 |
T8976 |
T8974 |
nsubj |
pathway,was |
R5701 |
T8977 |
T8978 |
compound |
Wnt,noggin |
R5702 |
T8984 |
T8985 |
det |
These,data |
R5703 |
T8978 |
T8976 |
compound |
noggin,pathway |
R5704 |
T8979 |
T8978 |
punct |
-,noggin |
R5705 |
T8980 |
T8976 |
compound |
signaling,pathway |
R5706 |
T8981 |
T8974 |
acomp |
intact,was |
R5707 |
T8985 |
T8986 |
nsubj |
data,suggest |
R5708 |
T8987 |
T8988 |
mark |
that,functions |
R5709 |
T8988 |
T8986 |
ccomp |
functions,suggest |
R5710 |
T8989 |
T8988 |
prep |
during,functions |
R5711 |
T8990 |
T8991 |
compound |
hair,follicle |
R5712 |
T8991 |
T8992 |
compound |
follicle,morphogenesis |
R5713 |
T8992 |
T8989 |
pobj |
morphogenesis,during |
R5714 |
T8993 |
T8988 |
punct |
", ",functions |
R5715 |
T8994 |
T8995 |
compound |
TGF,β2 |
R5716 |
T8995 |
T8988 |
nsubj |
β2,functions |
R5717 |
T8996 |
T8995 |
punct |
-,β2 |
R5718 |
T8997 |
T8988 |
advmod |
subsequently,functions |
R5719 |
T8998 |
T8997 |
prep |
to,subsequently |
R5720 |
T8999 |
T9000 |
compound |
Wnt,noggin |
R5721 |
T9000 |
T9002 |
npadvmod |
noggin,mediated |
R5722 |
T9001 |
T9000 |
punct |
/,noggin |
R5723 |
T9002 |
T9004 |
amod |
mediated,determination |
R5724 |
T9003 |
T9002 |
punct |
-,mediated |
R5725 |
T9004 |
T8998 |
pobj |
determination,to |
R5726 |
T9005 |
T9004 |
prep |
of,determination |
R5727 |
T9006 |
T9007 |
compound |
hair,fate |
R5728 |
T9007 |
T9005 |
pobj |
fate,of |
R5729 |
T9008 |
T8986 |
punct |
.,suggest |
R5730 |
T9010 |
T9011 |
advmod |
Moreover,appears |
R5731 |
T9012 |
T9011 |
punct |
", ",appears |
R5732 |
T9013 |
T9011 |
prep |
through,appears |
R5733 |
T9014 |
T9013 |
pobj |
activation,through |
R5734 |
T9015 |
T9014 |
prep |
of,activation |
R5735 |
T9016 |
T9017 |
compound |
Snail,expression |
R5736 |
T9017 |
T9015 |
pobj |
expression,of |
R5737 |
T9018 |
T9017 |
compound |
gene,expression |
R5738 |
T9019 |
T9011 |
punct |
", ",appears |
R5739 |
T9020 |
T9021 |
compound |
TGF,β2 |
R5740 |
T9021 |
T9011 |
nsubj |
β2,appears |
R5741 |
T9022 |
T9021 |
punct |
-,β2 |
R5742 |
T9023 |
T9024 |
aux |
to,work |
R5743 |
T9024 |
T9011 |
xcomp |
work,appears |
R5744 |
T9025 |
T9024 |
prep |
in,work |
R5745 |
T9026 |
T9025 |
pobj |
tandem,in |
R5746 |
T9027 |
T9026 |
prep |
with,tandem |
R5747 |
T9028 |
T9029 |
det |
these,morphogens |
R5748 |
T9029 |
T9027 |
pobj |
morphogens,with |
R5749 |
T9030 |
T9029 |
amod |
other,morphogens |
R5750 |
T9031 |
T9032 |
aux |
to,regulate |
R5751 |
T9032 |
T9024 |
advcl |
regulate,work |
R5752 |
T9033 |
T9032 |
advmod |
down,regulate |
R5753 |
T9034 |
T9032 |
punct |
-,regulate |
R5754 |
T9035 |
T9036 |
compound |
E,cadherin |
R5755 |
T9036 |
T9038 |
compound |
cadherin,levels |
R5756 |
T9037 |
T9036 |
punct |
-,cadherin |
R5757 |
T9038 |
T9032 |
dobj |
levels,regulate |
R5758 |
T9039 |
T9024 |
punct |
", ",work |
R5759 |
T9040 |
T9041 |
dep |
which,contributes |
R5760 |
T9041 |
T9024 |
advcl |
contributes,work |
R5761 |
T9042 |
T9041 |
prep |
to,contributes |
R5762 |
T9043 |
T9044 |
det |
the,activation |
R5763 |
T9044 |
T9042 |
pobj |
activation,to |
R5764 |
T9045 |
T9044 |
prep |
of,activation |
R5765 |
T9046 |
T9047 |
amod |
proliferative,circuitries |
R5766 |
T9047 |
T9045 |
pobj |
circuitries,of |
R5767 |
T9048 |
T9011 |
punct |
.,appears |