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PMC:539061 / 15644-22933 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3694 10-20 GO:0010467 denotes Expression
T3695 24-29 PR:000015308 denotes Snail
T3696 41-50 UBERON:0007376 denotes Epidermal
T3697 56-69 GO:0008283 denotes proliferation
T3698 104-109 NCBITaxon:10088 denotes Mouse
T3699 137-142 PR:000015308 denotes Snail
T3700 143-153 GO:0010467 denotes expression
T3701 170-174 UBERON:0001037 denotes hair
T3702 202-215 GO:0008283 denotes proliferation
T3703 271-281 GO:0010467 denotes expressing
T3704 282-287 PR:000015308 denotes Snail
T3705 301-306 NCBITaxon:10088 denotes mouse
T3706 307-321 UBERON:0001003 denotes skin epidermis
T3707 357-362 PR:000015308 denotes Snail
T3708 418-423 PR:000015308 denotes Snail
T3709 463-466 PR:000009454 denotes K14
T3710 467-472 PR:000015308 denotes Snail
T3711 480-487 NCBITaxon:33208 denotes animals
T3712 505-514 GO:0010467 denotes expressed
T3713 519-528 SO:0000902 denotes transgene
T3714 569-573 NCBITaxon:10088 denotes Mice
T3715 594-603 SO:0000902 denotes transgene
T3716 629-633 GO:0016265 denotes died
T3717 654-659 GO:0007567 denotes birth
T3718 697-701 NCBITaxon:10088 denotes mice
T3719 711-720 SO:0000902 denotes transgene
T3720 774-779 PR:000015308 denotes Snail
T3721 780-784 SO:0000704 denotes gene
T3722 780-795 GO:0010467 denotes gene expression
T3723 922-927 GO:0007567 denotes birth
T3724 932-937 PR:000015308 denotes Snail
T3725 941-948 NCBITaxon:33208 denotes animals
T3726 949-953 GO:0040007 denotes grew
T3727 1008-1013 UBERON:0002415 denotes tails
T3728 1081-1085 NCBITaxon:10088 denotes mice
T3729 1120-1129 UBERON:0007376 denotes epidermal
T3730 1209-1214 PR:000015308 denotes Snail
T3731 1261-1271 GO:0010467 denotes expressing
T3732 1272-1279 GO:0005634 denotes nuclear
T3733 1290-1295 PR:000015308 denotes Snail
T3734 1361-1374 GO:0008283 denotes proliferation
T3735 1391-1401 GO:0042571 denotes antibodies
T3736 1414-1427 GO:0008283 denotes proliferating
T3737 1428-1435 GO:0005634 denotes nuclear
T3738 1436-1443 CHEBI:59132 denotes antigen
T3739 1444-1448 PR:000010425 denotes Ki67
T3740 1570-1580 GO:0010467 denotes expressing
T3741 1617-1634 UBERON:0010402 denotes suprabasal layers
T3742 3666-3676 GO:0010467 denotes Expression
T3743 3684-3689 PR:000015308 denotes Snail
T3744 3690-3699 SO:0000902 denotes transgene
T3745 3765-3774 UBERON:0007376 denotes epidermis
T3746 3842-3855 GO:0008283 denotes proliferating
T3747 3868-3873 PR:000015308 denotes Snail
T3748 3874-3884 GO:0010467 denotes expression
T3749 3913-3919 _FRAGMENT denotes layers
T3750 3925-3932 UBERON:0002026 denotes spinous
T3751 4020-4029 PR:000009481 denotes keratin 5
T3752 4031-4033 PR:000009481 denotes K5
T3753 4073-4084 UBERON:0002025 denotes basal layer
T3754 4125-4130 PR:000015308 denotes Snail
T3755 4136-4140 NCBITaxon:10088 denotes mice
T3756 4157-4169 GO:0007369 denotes gastrulation
T3757 4218-4223 PR:000015308 denotes Snail
T3758 4236-4252 GO:0043588 denotes skin development
T3759 4293-4303 GO:0010467 denotes expression
T3760 4307-4312 PR:000015308 denotes Snail
T3761 4342-4344 PR:000009481 denotes K5
T3762 4346-4350 PR:000010425 denotes Ki67
T3763 4362-4374 UBERON:0010402 denotes suprabasally
T3764 6283-6296 GO:0008283 denotes proliferation
T3765 6366-6376 UBERON:0000483 denotes epithelial
T3766 6411-6420 UBERON:0007376 denotes epidermal
T3767 6468-6473 PR:000015308 denotes Snail
T3768 6478-6487 GO:0010467 denotes expressed
T3769 6739-6749 GO:0042571 denotes antibodies
T3770 6776-6790 GO:0030056 denotes hemidesmosomes
T3771 6825-6846 CL:0002187 denotes basal epidermal cells
T3772 6831-6840 UBERON:0007376 denotes epidermal
T3773 6980-6984 UBERON:0001037 denotes hair
T3774 6992-7001 UBERON:0000922 denotes embryonic
T3775 7014-7018 NCBITaxon:10088 denotes mice
T3776 7024-7029 PR:000015308 denotes Snail
T3777 7042-7051 GO:0010467 denotes expressed
T3778 7104-7113 UBERON:0007376 denotes epidermis
T3779 7123-7129 UBERON:0002067 denotes dermis
T3780 7153-7158 UBERON:0007023 denotes adult
T3781 7162-7169 NCBITaxon:33208 denotes animals
T3782 7251-7260 UBERON:0007376 denotes epidermis
R2287 T3750 T3749 _lexicallyChainedTo spinous,layers

2_test

Id Subject Object Predicate Lexical cue
15630473-10655587-84810261 452-454 10655587 denotes 12
15630473-11689706-84810262 4171-4173 11689706 denotes 21
T65812 452-454 10655587 denotes 12
T54526 4171-4173 11689706 denotes 21

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T3783 10-20 GO:0010467 denotes Expression
T3784 24-29 PR_EXT:000015308 denotes Snail
T3785 41-50 UBERON:0007376 denotes Epidermal
T3786 56-69 GO:0008283 denotes proliferation
T3787 74-89 GO_RO_EXT:developmental_differentiation_process denotes Differentiation
T3788 101-103 SO_EXT:transgenic_entity denotes Tg
T3789 104-109 NCBITaxon:10088 denotes Mouse
T3790 110-114 UBERON_EXT:zone_of_skin_or_skin_of_body denotes Skin
T3791 137-142 PR_EXT:000015308 denotes Snail
T3792 143-153 GO:0010467 denotes expression
T3793 170-174 UBERON:0001037 denotes hair
T3794 202-215 GO:0008283 denotes proliferation
T3795 271-281 GO:0010467 denotes expressing
T3796 282-287 PR_EXT:000015308 denotes Snail
T3797 301-306 NCBITaxon:10088 denotes mouse
T3798 307-321 UBERON:0001003 denotes skin epidermis
T3799 338-340 SO_EXT:transgenic_entity denotes Tg
T3800 357-362 PR_EXT:000015308 denotes Snail
T3801 379-386 CHEBI_SO_EXT:epitope denotes epitope
T3802 418-423 PR_EXT:000015308 denotes Snail
T3803 426-441 GO_EXT:transcription denotes transcriptional
T3804 463-466 PR_EXT:000009454 denotes K14
T3805 467-472 PR_EXT:000015308 denotes Snail
T3806 477-479 SO_EXT:transgenic_entity denotes Tg
T3807 480-487 NCBITaxon:33208 denotes animals
T3808 505-514 GO:0010467 denotes expressed
T3809 519-528 SO_EXT:0000902 denotes transgene
T3810 569-573 NCBITaxon:10088 denotes Mice
T3811 594-603 SO_EXT:0000902 denotes transgene
T3812 618-622 CL_GO_EXT:cell denotes cell
T3813 629-633 GO:0016265 denotes died
T3814 654-659 GO:0007567 denotes birth
T3815 686-688 SO_EXT:transgenic_entity denotes Tg
T3816 697-701 NCBITaxon:10088 denotes mice
T3817 711-720 SO_EXT:0000902 denotes transgene
T3818 774-779 PR_EXT:000015308 denotes Snail
T3819 780-784 SO_EXT:0000704 denotes gene
T3820 780-795 GO:0010467 denotes gene expression
T3821 861-872 GO_EXT:killing denotes sacrificing
T3822 922-927 GO:0007567 denotes birth
T3823 932-937 PR_EXT:000015308 denotes Snail
T3824 938-940 SO_EXT:transgenic_entity denotes Tg
T3825 941-948 NCBITaxon:33208 denotes animals
T3826 949-953 GO:0040007 denotes grew
T3827 1008-1013 UBERON:0002415 denotes tails
T3828 1025-1029 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T3829 1081-1085 NCBITaxon:10088 denotes mice
T3830 1120-1129 UBERON:0007376 denotes epidermal
T3831 1206-1208 SO_EXT:transgenic_entity denotes Tg
T3832 1209-1214 PR_EXT:000015308 denotes Snail
T3833 1215-1222 CHEBI_PR_EXT:protein denotes protein
T3834 1261-1271 GO:0010467 denotes expressing
T3835 1272-1279 GO:0005634 denotes nuclear
T3836 1283-1289 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes tagged
T3837 1290-1295 PR_EXT:000015308 denotes Snail
T3838 1361-1374 GO:0008283 denotes proliferation
T3839 1391-1401 GO:0042571 denotes antibodies
T3840 1414-1427 GO:0008283 denotes proliferating
T3841 1428-1435 GO:0005634 denotes nuclear
T3842 1436-1443 CHEBI_EXT:59132 denotes antigen
T3843 1444-1448 PR_EXT:000010425 denotes Ki67
T3844 1495-1500 CL_GO_EXT:cell denotes cells
T3845 1564-1569 CL_GO_EXT:cell denotes cells
T3846 1570-1580 GO:0010467 denotes expressing
T3847 1581-1590 PR_EXT:keratin_6 denotes keratin 6
T3848 1617-1634 UBERON:0010402 denotes suprabasal layers
T3849 1643-1656 GO_PATO_EXT:cell_proliferation_or_proliferativity denotes proliferative
T3850 1657-1661 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T3851 3666-3676 GO:0010467 denotes Expression
T3852 3684-3689 PR_EXT:000015308 denotes Snail
T3853 3690-3699 SO_EXT:0000902 denotes transgene
T3854 3723-3738 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3855 3751-3764 GO_PATO_EXT:cell_proliferation_or_proliferativity denotes proliferative
T3856 3765-3774 UBERON:0007376 denotes epidermis
T3857 3842-3855 GO:0008283 denotes proliferating
T3858 3868-3873 PR_EXT:000015308 denotes Snail
T3859 3874-3884 GO:0010467 denotes expression
T3860 3913-3919 _FRAGMENT denotes layers
T3861 3925-3932 UBERON:0002026 denotes spinous
T3862 4020-4029 PR_EXT:000009481 denotes keratin 5
T3863 4031-4033 PR_EXT:000009481 denotes K5
T3864 4073-4084 UBERON:0002025 denotes basal layer
T3865 4125-4130 PR_EXT:000015308 denotes Snail
T3866 4131-4135 SO_EXT:sequence_nullness denotes null
T3867 4136-4140 NCBITaxon:10088 denotes mice
T3868 4157-4169 GO:0007369 denotes gastrulation
T3869 4218-4223 PR_EXT:000015308 denotes Snail
T3870 4236-4240 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T3871 4236-4252 GO:0043588 denotes skin development
T3872 4293-4303 GO:0010467 denotes expression
T3873 4307-4312 PR_EXT:000015308 denotes Snail
T3874 4313-4320 CHEBI_PR_EXT:protein denotes protein
T3875 4342-4344 PR_EXT:000009481 denotes K5
T3876 4346-4350 PR_EXT:000010425 denotes Ki67
T3877 4362-4374 UBERON:0010402 denotes suprabasally
T3878 6283-6296 GO:0008283 denotes proliferation
T3879 6301-6316 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T3880 6366-6376 UBERON:0000483 denotes epithelial
T3881 6411-6420 UBERON:0007376 denotes epidermal
T3882 6468-6473 PR_EXT:000015308 denotes Snail
T3883 6478-6487 GO:0010467 denotes expressed
T3884 6493-6506 GO_PATO_EXT:cell_proliferation_or_proliferativity denotes proliferative
T3885 6507-6514 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T3886 6566-6574 PR_EXT:cyclin_D denotes cyclin D
T3887 6660-6677 GO_UBERON_EXT:basement_membrane denotes basement membrane
T3888 6739-6749 GO:0042571 denotes antibodies
T3889 6776-6790 GO:0030056 denotes hemidesmosomes
T3890 6813-6821 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T3891 6825-6846 CL:0002187 denotes basal epidermal cells
T3892 6831-6840 UBERON:0007376 denotes epidermal
T3893 6841-6846 CL_GO_EXT:cell denotes cells
T3894 6865-6877 GO_UBERON_EXT:basal_lamina denotes basal lamina
T3895 6955-6972 GO_UBERON_EXT:basement_membrane denotes basement membrane
T3896 6980-6984 UBERON:0001037 denotes hair
T3897 6992-7001 UBERON:0000922 denotes embryonic
T3898 7006-7013 PATO_UBERON_EXT:neonate_or_newborn denotes newborn
T3899 7014-7018 NCBITaxon:10088 denotes mice
T3900 7024-7029 PR_EXT:000015308 denotes Snail
T3901 7042-7051 GO:0010467 denotes expressed
T3902 7071-7088 GO_UBERON_EXT:basement_membrane denotes basement membrane
T3903 7104-7113 UBERON:0007376 denotes epidermis
T3904 7123-7129 UBERON:0002067 denotes dermis
T3905 7153-7158 UBERON:0007023 denotes adult
T3906 7159-7161 SO_EXT:transgenic_entity denotes Tg
T3907 7162-7169 NCBITaxon:33208 denotes animals
T3908 7251-7260 UBERON:0007376 denotes epidermis
T3909 7280-7288 UBERON_EXT:follicle denotes follicle
R2288 T3861 T3860 _lexicallyChainedTo spinous,layers

craft-sa-dev

Id Subject Object Predicate Lexical cue
T3910 0-9 JJ denotes Sustained
T3911 10-20 NN denotes Expression
T3912 30-37 VBZ denotes Results
T3913 21-23 IN denotes of
T3914 24-29 NN denotes Snail
T3915 38-40 IN denotes in
T3916 41-50 JJ denotes Epidermal
T3917 51-69 NN denotes Hyperproliferation
T3918 70-73 CC denotes and
T3919 74-89 NN denotes Differentiation
T3920 90-97 NNS denotes Defects
T3921 98-100 IN denotes in
T3922 101-103 NN denotes Tg
T3923 110-114 NN denotes Skin
T3924 104-109 NN denotes Mouse
T3925 114-322 sentence denotes The striking spike of Snail expression coincident with hair bud formation and enhanced proliferation prompted us to examine the consequences of ectopically expressing Snail elsewhere in mouse skin epidermis.
T3926 115-118 DT denotes The
T3927 128-133 NN denotes spike
T3928 119-127 JJ denotes striking
T3929 216-224 VBD denotes prompted
T3930 134-136 IN denotes of
T3931 137-142 NN denotes Snail
T3932 143-153 NN denotes expression
T3933 154-164 JJ denotes coincident
T3934 165-169 IN denotes with
T3935 170-174 NN denotes hair
T3936 175-178 NN denotes bud
T3937 179-188 NN denotes formation
T3938 189-192 CC denotes and
T3939 193-201 VBN denotes enhanced
T3940 202-215 NN denotes proliferation
T3941 225-227 PRP denotes us
T3942 228-230 TO denotes to
T3943 231-238 VB denotes examine
T3944 239-242 DT denotes the
T3945 243-255 NNS denotes consequences
T3946 256-258 IN denotes of
T3947 259-270 RB denotes ectopically
T3948 271-281 VBG denotes expressing
T3949 282-287 NN denotes Snail
T3950 288-297 RB denotes elsewhere
T3951 298-300 IN denotes in
T3952 301-306 NN denotes mouse
T3953 312-321 NN denotes epidermis
T3954 307-311 NN denotes skin
T3955 321-322 . denotes .
T3956 322-456 sentence denotes To distinguish Tg from endogenous Snail, we used the HA-epitope, shown previously not to alter Snail's transcriptional activity [12].
T3957 323-325 TO denotes To
T3958 326-337 VB denotes distinguish
T3959 367-371 VBD denotes used
T3960 338-340 NN denotes Tg
T3961 341-345 IN denotes from
T3962 346-356 JJ denotes endogenous
T3963 357-362 NN denotes Snail
T3964 362-364 , denotes ,
T3965 364-366 PRP denotes we
T3966 372-375 DT denotes the
T3967 379-386 NN denotes epitope
T3968 376-378 NN denotes HA
T3969 378-379 HYPH denotes -
T3970 386-388 , denotes ,
T3971 388-393 VBN denotes shown
T3972 394-404 RB denotes previously
T3973 405-408 RB denotes not
T3974 412-417 VB denotes alter
T3975 409-411 TO denotes to
T3976 418-423 NNP denotes Snail
T3977 442-450 NN denotes activity
T3978 423-425 POS denotes 's
T3979 426-441 JJ denotes transcriptional
T3980 451-452 -LRB- denotes [
T3981 452-454 CD denotes 12
T3982 454-455 -RRB- denotes ]
T3983 455-456 . denotes .
T3984 456-568 sentence denotes Of 20 K14-Snail[HA] Tg animals generated, three expressed the transgene and all exhibited analogous phenotypes.
T3985 457-459 IN denotes Of
T3986 505-514 VBD denotes expressed
T3987 460-462 CD denotes 20
T3988 480-487 NNS denotes animals
T3989 463-466 NN denotes K14
T3990 467-472 NN denotes Snail
T3991 466-467 HYPH denotes -
T3992 472-473 -LRB- denotes [
T3993 473-475 NN denotes HA
T3994 475-476 -RRB- denotes ]
T3995 477-479 NN denotes Tg
T3996 488-497 VBN denotes generated
T3997 497-499 , denotes ,
T3998 499-504 CD denotes three
T3999 515-518 DT denotes the
T4000 519-528 NN denotes transgene
T4001 529-532 CC denotes and
T4002 533-536 DT denotes all
T4003 537-546 VBD denotes exhibited
T4004 547-556 JJ denotes analogous
T4005 557-567 NNS denotes phenotypes
T4006 567-568 . denotes .
T4007 568-660 sentence denotes Mice that integrated the transgene at the single-cell stage died at or shortly after birth.
T4008 569-573 NNS denotes Mice
T4009 629-633 VBD denotes died
T4010 574-578 WDT denotes that
T4011 579-589 VBD denotes integrated
T4012 590-593 DT denotes the
T4013 594-603 NN denotes transgene
T4014 604-606 IN denotes at
T4015 607-610 DT denotes the
T4016 623-628 NN denotes stage
T4017 611-617 JJ denotes single
T4018 618-622 NN denotes cell
T4019 617-618 HYPH denotes -
T4020 634-636 IN denotes at
T4021 637-639 CC denotes or
T4022 640-647 RB denotes shortly
T4023 648-653 IN denotes after
T4024 654-659 NN denotes birth
T4025 659-660 . denotes .
T4026 660-817 sentence denotes The three surviving full-Tg founder mice harbored transgene integrations that gave stable transmission of mosaic Snail gene expression through the germline.
T4027 661-664 DT denotes The
T4028 697-701 NNS denotes mice
T4029 665-670 CD denotes three
T4030 671-680 VBG denotes surviving
T4031 681-685 JJ denotes full
T4032 686-688 NN denotes Tg
T4033 685-686 HYPH denotes -
T4034 689-696 NN denotes founder
T4035 702-710 VBD denotes harbored
T4036 711-720 NN denotes transgene
T4037 721-733 NNS denotes integrations
T4038 734-738 WDT denotes that
T4039 739-743 VBD denotes gave
T4040 744-750 JJ denotes stable
T4041 751-763 NN denotes transmission
T4042 764-766 IN denotes of
T4043 767-773 JJ denotes mosaic
T4044 780-784 NN denotes gene
T4045 774-779 NN denotes Snail
T4046 785-795 NN denotes expression
T4047 796-803 IN denotes through
T4048 804-807 DT denotes the
T4049 808-816 NN denotes germline
T4050 816-817 . denotes .
T4051 817-928 sentence denotes Progressively poor health necessitated our sacrificing most offspring from these lines within a year of birth.
T4052 818-831 RB denotes Progressively
T4053 832-836 JJ denotes poor
T4054 837-843 NN denotes health
T4055 844-856 VBD denotes necessitated
T4056 857-860 PRP$ denotes our
T4057 861-872 VBG denotes sacrificing
T4058 873-877 JJS denotes most
T4059 878-887 NN denotes offspring
T4060 888-892 IN denotes from
T4061 893-898 DT denotes these
T4062 899-904 NNS denotes lines
T4063 905-911 IN denotes within
T4064 912-913 DT denotes a
T4065 914-918 NN denotes year
T4066 919-921 IN denotes of
T4067 922-927 NN denotes birth
T4068 927-928 . denotes .
T4069 928-1042 sentence denotes As Snail Tg animals grew, they became distinguished by their small size, short tails, and flaky skin (Figure 2A).
T4070 929-931 IN denotes As
T4071 949-953 VBD denotes grew
T4072 932-937 NN denotes Snail
T4073 941-948 NNS denotes animals
T4074 938-940 NN denotes Tg
T4075 960-966 VBD denotes became
T4076 953-955 , denotes ,
T4077 955-959 PRP denotes they
T4078 967-980 JJ denotes distinguished
T4079 981-983 IN denotes by
T4080 984-989 PRP$ denotes their
T4081 996-1000 NN denotes size
T4082 990-995 JJ denotes small
T4083 1000-1002 , denotes ,
T4084 1002-1007 JJ denotes short
T4085 1008-1013 NNS denotes tails
T4086 1013-1015 , denotes ,
T4087 1015-1018 CC denotes and
T4088 1019-1024 JJ denotes flaky
T4089 1025-1029 NN denotes skin
T4090 1030-1031 -LRB- denotes (
T4091 1038-1040 NN denotes 2A
T4092 1031-1037 NN denotes Figure
T4093 1040-1041 -RRB- denotes )
T4094 1041-1042 . denotes .
T4095 1042-1153 sentence denotes Histological analyses of 3-d old (P3) mice revealed mosaic patches marked by epidermal thickening (Figure 2B).
T4096 1043-1055 JJ denotes Histological
T4097 1056-1064 NNS denotes analyses
T4098 1086-1094 VBD denotes revealed
T4099 1065-1067 IN denotes of
T4100 1068-1069 CD denotes 3
T4101 1070-1071 NN denotes d
T4102 1069-1070 HYPH denotes -
T4103 1072-1075 JJ denotes old
T4104 1081-1085 NNS denotes mice
T4105 1076-1077 -LRB- denotes (
T4106 1077-1079 JJ denotes P3
T4107 1079-1080 -RRB- denotes )
T4108 1095-1101 NN denotes mosaic
T4109 1102-1109 NNS denotes patches
T4110 1110-1116 VBN denotes marked
T4111 1117-1119 IN denotes by
T4112 1120-1129 JJ denotes epidermal
T4113 1130-1140 NN denotes thickening
T4114 1141-1142 -LRB- denotes (
T4115 1149-1151 NN denotes 2B
T4116 1142-1148 NN denotes Figure
T4117 1151-1152 -RRB- denotes )
T4118 1152-1153 . denotes .
T4119 1153-1308 sentence denotes The mosaic morphology was reflected at the level of Tg Snail protein, with only the hyperthickened regions expressing nuclear HA-tagged Snail (Figure 2C).
T4120 1154-1157 DT denotes The
T4121 1165-1175 NN denotes morphology
T4122 1158-1164 NN denotes mosaic
T4123 1180-1189 VBN denotes reflected
T4124 1176-1179 VBD denotes was
T4125 1190-1192 IN denotes at
T4126 1193-1196 DT denotes the
T4127 1197-1202 NN denotes level
T4128 1203-1205 IN denotes of
T4129 1206-1208 NN denotes Tg
T4130 1215-1222 NN denotes protein
T4131 1209-1214 NN denotes Snail
T4132 1222-1224 , denotes ,
T4133 1224-1228 IN denotes with
T4134 1261-1271 VBG denotes expressing
T4135 1229-1233 RB denotes only
T4136 1253-1260 NNS denotes regions
T4137 1234-1237 DT denotes the
T4138 1238-1252 VBN denotes hyperthickened
T4139 1272-1279 JJ denotes nuclear
T4140 1290-1295 NN denotes Snail
T4141 1280-1282 NN denotes HA
T4142 1283-1289 VBN denotes tagged
T4143 1282-1283 HYPH denotes -
T4144 1296-1297 -LRB- denotes (
T4145 1304-1306 NN denotes 2C
T4146 1297-1303 NN denotes Figure
T4147 1306-1307 -RRB- denotes )
T4148 1307-1308 . denotes .
T4149 1308-1468 sentence denotes These hyperthickened areas were marked by excessive proliferation, as revealed by antibodies against the proliferating nuclear antigen Ki67 (Figure 2D and 2E).
T4150 1309-1314 DT denotes These
T4151 1330-1335 NNS denotes areas
T4152 1315-1329 VBN denotes hyperthickened
T4153 1341-1347 VBN denotes marked
T4154 1336-1340 VBD denotes were
T4155 1348-1350 IN denotes by
T4156 1351-1360 JJ denotes excessive
T4157 1361-1374 NN denotes proliferation
T4158 1374-1376 , denotes ,
T4159 1376-1378 IN denotes as
T4160 1379-1387 VBN denotes revealed
T4161 1388-1390 IN denotes by
T4162 1391-1401 NNS denotes antibodies
T4163 1402-1409 IN denotes against
T4164 1410-1413 DT denotes the
T4165 1436-1443 NN denotes antigen
T4166 1414-1427 VBG denotes proliferating
T4167 1428-1435 JJ denotes nuclear
T4168 1444-1448 NN denotes Ki67
T4169 1449-1450 -LRB- denotes (
T4170 1457-1459 NN denotes 2D
T4171 1450-1456 NN denotes Figure
T4172 1460-1463 CC denotes and
T4173 1464-1466 NN denotes 2E
T4174 1466-1467 -RRB- denotes )
T4175 1467-1468 . denotes .
T4176 1468-1681 sentence denotes Activated, pMAPK-positive cells were also prevalent in these areas (Figure 2F and 2G), as were cells expressing keratin 6, a keratin induced in the suprabasal layers of hyperproliferative skin (Figure 2H and 2I).
T4177 1469-1478 VBN denotes Activated
T4178 1495-1500 NNS denotes cells
T4179 1478-1480 , denotes ,
T4180 1480-1485 NN denotes pMAPK
T4181 1486-1494 JJ denotes positive
T4182 1485-1486 HYPH denotes -
T4183 1501-1505 VBD denotes were
T4184 1506-1510 RB denotes also
T4185 1511-1520 JJ denotes prevalent
T4186 1521-1523 IN denotes in
T4187 1524-1529 DT denotes these
T4188 1530-1535 NNS denotes areas
T4189 1536-1537 -LRB- denotes (
T4190 1544-1546 NN denotes 2F
T4191 1537-1543 NN denotes Figure
T4192 1547-1550 CC denotes and
T4193 1551-1553 NN denotes 2G
T4194 1553-1554 -RRB- denotes )
T4195 1554-1556 , denotes ,
T4196 1556-1558 IN denotes as
T4197 1559-1563 VBD denotes were
T4198 1564-1569 NNS denotes cells
T4199 1570-1580 VBG denotes expressing
T4200 1581-1588 NN denotes keratin
T4201 1589-1590 CD denotes 6
T4202 1590-1592 , denotes ,
T4203 1592-1593 DT denotes a
T4204 1594-1601 NN denotes keratin
T4205 1602-1609 VBN denotes induced
T4206 1610-1612 IN denotes in
T4207 1613-1616 DT denotes the
T4208 1628-1634 NNS denotes layers
T4209 1617-1627 JJ denotes suprabasal
T4210 1635-1637 IN denotes of
T4211 1638-1656 JJ denotes hyperproliferative
T4212 1657-1661 NN denotes skin
T4213 1662-1663 -LRB- denotes (
T4214 1670-1672 NN denotes 2H
T4215 1663-1669 NN denotes Figure
T4216 1673-1676 CC denotes and
T4217 1677-1679 NN denotes 2I
T4218 1679-1680 -RRB- denotes )
T4219 1680-1681 . denotes .
T4220 1681-3820 sentence denotes Figure 2 Misexpression of Snail in Mouse Skin Epidermis Results in Hyperproliferation Three different surviving Tg founder mice harbored a K14-Snail transgene that was integrated into a locus that resulted in inheritable, mosaic expression of the transgene in skin epidermis. All displayed similar abnormalities, as did their offspring. (A) P16 WT and K14-Snail Tg mice. Insets denote magnified tail segments, which displayed a mosaic, flaky appearance in Tg mice. Size differences appeared with age, and are likely due to K14-promoter activity in the tongue and oral epithelium, resulting in progressive defects and reduced food intake. Hence, skin sections from young (P3) mice were analyzed (B–I). (B) Hematoxylin- and eosin-stained Tg skin section. Double arrows demarcate the border of mosaic histology, with seemingly normal epidermis (epi) and a mature hair follicle (hf) at left and hyperthickened epidermis at right. (C) Immunofluorescence of Tg skin section labeled with antibodies as color-coded on frame. Double arrows demarcate the border of mosaic anti-Snail (green), revealing Snail expression coincident with regions of hyperthickened epidermis (at left) and absent in regions of normal epidermis (at right). (D–I) Sections of P3 WT or Tg skin (affected region) subjected to either immunofluorescence (D, E, H, and I) or immunohistochemistry (F and G) with antibodies as indicated on the panel. Anti-keratin 5 indicates K5, normally restricted to the basal layer of the epidermis; anti-keratin 6 detects keratin 6, expressed in postnatal epidermis under conditions such as wounding, in which hyperproliferation occurs. All other antibodies are as in the legend to Figure 2. Comparison of D and E provide representative examples that illustrate that pMAPK is found in only a subset of all proliferating (Ki67-positive) cells. Note also the presence of Ki67- (E) and pMAPK-positive (G) cells in some suprabasal areas; Ki67-positive cells colabeled with anti-Snail (E). Expression of the Snail transgene did not block terminal differentiation in the hyperproliferative epidermis, but it distorted it markedly (Figure 3A–3H).
T4221 3666-3676 NN denotes Expression
T4222 3708-3713 VB denotes block
T4223 3677-3679 IN denotes of
T4224 3680-3683 DT denotes the
T4225 3690-3699 NN denotes transgene
T4226 3684-3689 NN denotes Snail
T4227 3700-3703 VBD denotes did
T4228 3704-3707 RB denotes not
T4229 3714-3722 JJ denotes terminal
T4230 3723-3738 NN denotes differentiation
T4231 3739-3741 IN denotes in
T4232 3742-3745 DT denotes the
T4233 3765-3774 NN denotes epidermis
T4234 3746-3764 JJ denotes hyperproliferative
T4235 3774-3776 , denotes ,
T4236 3776-3779 CC denotes but
T4237 3780-3782 PRP denotes it
T4238 3783-3792 VBD denotes distorted
T4239 3793-3795 PRP denotes it
T4240 3796-3804 RB denotes markedly
T4241 3805-3806 -LRB- denotes (
T4242 3813-3815 NN denotes 3A
T4243 3806-3812 NN denotes Figure
T4244 3815-3816 SYM denotes –
T4245 3816-3818 NN denotes 3H
T4246 3818-3819 -RRB- denotes )
T4247 3819-3820 . denotes .
T4248 3820-3957 sentence denotes Typical of most hyperproliferating conditions, Snail expression led to a large expansion in layers with spinous and granular morphology.
T4249 3821-3828 JJ denotes Typical
T4250 3885-3888 VBD denotes led
T4251 3829-3831 IN denotes of
T4252 3832-3836 JJS denotes most
T4253 3856-3866 NNS denotes conditions
T4254 3837-3855 NN denotes hyperproliferating
T4255 3866-3868 , denotes ,
T4256 3868-3873 NN denotes Snail
T4257 3874-3884 NN denotes expression
T4258 3889-3891 IN denotes to
T4259 3892-3893 DT denotes a
T4260 3900-3909 NN denotes expansion
T4261 3894-3899 JJ denotes large
T4262 3910-3912 IN denotes in
T4263 3913-3919 NNS denotes layers
T4264 3920-3924 IN denotes with
T4265 3925-3932 JJ denotes spinous
T4266 3946-3956 NN denotes morphology
T4267 3933-3936 CC denotes and
T4268 3937-3945 JJ denotes granular
T4269 3956-3957 . denotes .
T4270 3957-4100 sentence denotes Additionally, however, was a marked and variable expansion of keratin 5 (K5), normally restricted to the innermost basal layer (see Figure 3).
T4271 3958-3970 RB denotes Additionally
T4272 3981-3984 VBD denotes was
T4273 3970-3972 , denotes ,
T4274 3972-3979 RB denotes however
T4275 3979-3981 , denotes ,
T4276 3985-3986 DT denotes a
T4277 4007-4016 NN denotes expansion
T4278 3987-3993 JJ denotes marked
T4279 3994-3997 CC denotes and
T4280 3998-4006 JJ denotes variable
T4281 4017-4019 IN denotes of
T4282 4020-4027 NN denotes keratin
T4283 4028-4029 CD denotes 5
T4284 4030-4031 -LRB- denotes (
T4285 4031-4033 NN denotes K5
T4286 4033-4034 -RRB- denotes )
T4287 4034-4036 , denotes ,
T4288 4036-4044 RB denotes normally
T4289 4045-4055 VBN denotes restricted
T4290 4056-4058 IN denotes to
T4291 4059-4062 DT denotes the
T4292 4079-4084 NN denotes layer
T4293 4063-4072 JJS denotes innermost
T4294 4073-4078 JJ denotes basal
T4295 4085-4086 -LRB- denotes (
T4296 4086-4089 VB denotes see
T4297 4090-4096 NN denotes Figure
T4298 4097-4098 CD denotes 3
T4299 4098-4099 -RRB- denotes )
T4300 4099-4100 . denotes .
T4301 4100-4409 sentence denotes Although the failure of Snail-null mice to develop past gastrulation [21] precluded our ability to study the loss of Snail function in skin development, a good correlation emerged between the expression of Snail protein and the extension of K5, Ki67, and pMAPK suprabasally (compare data in Figures 2 and 3).
T4302 4101-4109 IN denotes Although
T4303 4175-4184 VBD denotes precluded
T4304 4110-4113 DT denotes the
T4305 4114-4121 NN denotes failure
T4306 4122-4124 IN denotes of
T4307 4125-4130 NN denotes Snail
T4308 4136-4140 NNS denotes mice
T4309 4130-4131 HYPH denotes -
T4310 4131-4135 JJ denotes null
T4311 4141-4143 TO denotes to
T4312 4144-4151 VB denotes develop
T4313 4152-4156 JJ denotes past
T4314 4157-4169 NN denotes gastrulation
T4315 4170-4171 -LRB- denotes [
T4316 4171-4173 CD denotes 21
T4317 4173-4174 -RRB- denotes ]
T4318 4273-4280 VBD denotes emerged
T4319 4185-4188 PRP$ denotes our
T4320 4189-4196 NN denotes ability
T4321 4197-4199 TO denotes to
T4322 4200-4205 VB denotes study
T4323 4206-4209 DT denotes the
T4324 4210-4214 NN denotes loss
T4325 4215-4217 IN denotes of
T4326 4218-4223 NN denotes Snail
T4327 4224-4232 NN denotes function
T4328 4233-4235 IN denotes in
T4329 4236-4240 NN denotes skin
T4330 4241-4252 NN denotes development
T4331 4252-4254 , denotes ,
T4332 4254-4255 DT denotes a
T4333 4261-4272 NN denotes correlation
T4334 4256-4260 JJ denotes good
T4335 4281-4288 IN denotes between
T4336 4289-4292 DT denotes the
T4337 4293-4303 NN denotes expression
T4338 4304-4306 IN denotes of
T4339 4307-4312 NN denotes Snail
T4340 4313-4320 NN denotes protein
T4341 4321-4324 CC denotes and
T4342 4325-4328 DT denotes the
T4343 4329-4338 NN denotes extension
T4344 4339-4341 IN denotes of
T4345 4342-4344 NN denotes K5
T4346 4344-4346 , denotes ,
T4347 4346-4350 NN denotes Ki67
T4348 4350-4352 , denotes ,
T4349 4352-4355 CC denotes and
T4350 4356-4361 NN denotes pMAPK
T4351 4362-4374 RB denotes suprabasally
T4352 4375-4376 -LRB- denotes (
T4353 4376-4383 VB denotes compare
T4354 4384-4388 NNS denotes data
T4355 4389-4391 IN denotes in
T4356 4392-4399 NNS denotes Figures
T4357 4400-4401 CD denotes 2
T4358 4402-4405 CC denotes and
T4359 4406-4407 CD denotes 3
T4360 4407-4408 -RRB- denotes )
T4361 4408-4409 . denotes .
T4362 4409-6391 sentence denotes Figure 3 Alterations in the Differentiation Program and Basement Membrane Organization in Snail-Expressing Tg Epidermis (A–H) Immunofluorescence of skin sections from P3 WT and Tg mice. Shown are affected areas of Tg skin; in areas where Snail protein was not expressed, stainings were normal. Sections were labeled with antibodies as indicated and color-coded on each frame. Antibodies are against markers of normal epidermal differentiation, and include K5 (a basally expressed keratin), K1 (a suprabasal keratin, expressed in spinous layer cells), involucrin (Inv; a suprabasally expressed cornified envelope protein found in upper spinous and granular layer cells), loricrin (Lor; a cornified envelope protein expressed in the granular layer), and filaggrin (Fil; a protein that bundles keratin filaments in the granular layer and stratum corneum). Note abnormal extension of anti-K5 suprabasally, often present in anti-K1 positive suprabasal Tg cells. (I–N) Immunohistochemistry (I and J) or immunofluorescence (K–N) of sections of P30 Wt (I, K, and M) and Tg (J, L, and N) (affected areas) skins using the antibodies indicated. Note that with age, affected areas of the Tg epidermis became increasingly undulating, often exhibiting papilloma-like invaginations (J). Insets in I and J are magnified views of the boxed areas, illustrating the absence (Wt) or presence (Tg) of nuclear anti-cyclin D staining. With age, affected areas of the Tg epidermis also displayed perturbations within the basement membrane, as judged by antibody labeling against either basement membrane (K and L) or hemidesmosomal (M and N) components. Double arrows in L demarcate mosaic zones, revealing that perturbations were restricted to hyperthickened, i.e., Snail-positive zones (to left of double arrows). Other abbreviations are as noted in the legend to Figure 2. The changes in hyperproliferation and differentiation were not initially accompanied by gross signs of epithelial invaginations.
T4363 6263-6266 DT denotes The
T4364 6267-6274 NNS denotes changes
T4365 6336-6347 VBN denotes accompanied
T4366 6275-6277 IN denotes in
T4367 6278-6296 NN denotes hyperproliferation
T4368 6297-6300 CC denotes and
T4369 6301-6316 NN denotes differentiation
T4370 6317-6321 VBD denotes were
T4371 6322-6325 RB denotes not
T4372 6326-6335 RB denotes initially
T4373 6348-6350 IN denotes by
T4374 6351-6356 JJ denotes gross
T4375 6357-6362 NNS denotes signs
T4376 6363-6365 IN denotes of
T4377 6366-6376 JJ denotes epithelial
T4378 6377-6390 NNS denotes invaginations
T4379 6390-6391 . denotes .
T4380 6391-6585 sentence denotes With age, however, epidermal folds and undulations developed in areas where Snail was expressed, and proliferative markers persisted in these regions (Figure 3I and 3J; anti-cyclin D staining).
T4381 6392-6396 IN denotes With
T4382 6443-6452 VBN denotes developed
T4383 6397-6400 NN denotes age
T4384 6400-6402 , denotes ,
T4385 6402-6409 RB denotes however
T4386 6409-6411 , denotes ,
T4387 6411-6420 JJ denotes epidermal
T4388 6421-6426 NNS denotes folds
T4389 6427-6430 CC denotes and
T4390 6431-6442 NNS denotes undulations
T4391 6453-6455 IN denotes in
T4392 6456-6461 NNS denotes areas
T4393 6462-6467 WRB denotes where
T4394 6478-6487 VBN denotes expressed
T4395 6468-6473 NN denotes Snail
T4396 6474-6477 VBD denotes was
T4397 6487-6489 , denotes ,
T4398 6489-6492 CC denotes and
T4399 6493-6506 JJ denotes proliferative
T4400 6507-6514 NNS denotes markers
T4401 6515-6524 VBD denotes persisted
T4402 6525-6527 IN denotes in
T4403 6528-6533 DT denotes these
T4404 6534-6541 NNS denotes regions
T4405 6542-6543 -LRB- denotes (
T4406 6575-6583 NN denotes staining
T4407 6543-6549 NN denotes Figure
T4408 6550-6552 NN denotes 3I
T4409 6553-6556 CC denotes and
T4410 6557-6559 NN denotes 3J
T4411 6559-6560 : denotes ;
T4412 6561-6572 JJ denotes anti-cyclin
T4413 6573-6574 NN denotes D
T4414 6583-6584 -RRB- denotes )
T4415 6584-6585 . denotes .
T4416 6585-6697 sentence denotes The undulations were accompanied by partial dissolution of the underlying basement membrane (Figure 3K and 3L).
T4417 6586-6589 DT denotes The
T4418 6590-6601 NNS denotes undulations
T4419 6607-6618 VBN denotes accompanied
T4420 6602-6606 VBD denotes were
T4421 6619-6621 IN denotes by
T4422 6622-6629 JJ denotes partial
T4423 6630-6641 NN denotes dissolution
T4424 6642-6644 IN denotes of
T4425 6645-6648 DT denotes the
T4426 6669-6677 NN denotes membrane
T4427 6649-6659 JJ denotes underlying
T4428 6660-6668 NN denotes basement
T4429 6678-6679 -LRB- denotes (
T4430 6686-6688 NN denotes 3K
T4431 6679-6685 NN denotes Figure
T4432 6689-6692 CC denotes and
T4433 6693-6695 NN denotes 3L
T4434 6695-6696 -RRB- denotes )
T4435 6696-6697 . denotes .
T4436 6697-6897 sentence denotes Aberrant staining was also observed with antibodies against components of the hemidesmosomes, which provide strong adhesion of basal epidermal cells to the underlying basal lamina (Figure 3M and 3N).
T4437 6698-6706 JJ denotes Aberrant
T4438 6707-6715 NN denotes staining
T4439 6725-6733 VBN denotes observed
T4440 6716-6719 VBD denotes was
T4441 6720-6724 RB denotes also
T4442 6734-6738 IN denotes with
T4443 6739-6749 NNS denotes antibodies
T4444 6750-6757 IN denotes against
T4445 6758-6768 NNS denotes components
T4446 6769-6771 IN denotes of
T4447 6772-6775 DT denotes the
T4448 6776-6790 NNS denotes hemidesmosomes
T4449 6790-6792 , denotes ,
T4450 6792-6797 WDT denotes which
T4451 6798-6805 VBP denotes provide
T4452 6806-6812 JJ denotes strong
T4453 6813-6821 NN denotes adhesion
T4454 6822-6824 IN denotes of
T4455 6825-6830 JJ denotes basal
T4456 6841-6846 NNS denotes cells
T4457 6831-6840 JJ denotes epidermal
T4458 6847-6849 IN denotes to
T4459 6850-6853 DT denotes the
T4460 6871-6877 NN denotes lamina
T4461 6854-6864 JJ denotes underlying
T4462 6865-6870 JJ denotes basal
T4463 6878-6879 -LRB- denotes (
T4464 6886-6888 NN denotes 3M
T4465 6879-6885 NN denotes Figure
T4466 6889-6892 CC denotes and
T4467 6893-6895 NN denotes 3N
T4468 6895-6896 -RRB- denotes )
T4469 6896-6897 . denotes .
T4470 6897-7052 sentence denotes Interestingly, similar types of alterations occur in the basement membrane in the hair bud of embryonic and newborn mice when Snail is normally expressed.
T4471 6898-6911 RB denotes Interestingly
T4472 6942-6947 VBP denotes occur
T4473 6911-6913 , denotes ,
T4474 6913-6920 JJ denotes similar
T4475 6921-6926 NNS denotes types
T4476 6927-6929 IN denotes of
T4477 6930-6941 NNS denotes alterations
T4478 6948-6950 IN denotes in
T4479 6951-6954 DT denotes the
T4480 6964-6972 NN denotes membrane
T4481 6955-6963 NN denotes basement
T4482 6973-6975 IN denotes in
T4483 6976-6979 DT denotes the
T4484 6985-6988 NN denotes bud
T4485 6980-6984 NN denotes hair
T4486 6989-6991 IN denotes of
T4487 6992-7001 JJ denotes embryonic
T4488 7014-7018 NNS denotes mice
T4489 7002-7005 CC denotes and
T4490 7006-7013 JJ denotes newborn
T4491 7019-7023 WRB denotes when
T4492 7042-7051 VBN denotes expressed
T4493 7024-7029 NN denotes Snail
T4494 7030-7032 VBZ denotes is
T4495 7033-7041 RB denotes normally
T4496 7051-7052 . denotes .
T4497 7052-7289 sentence denotes The fact that the basement membrane separating the epidermis from the dermis is altered only in the adult Tg animals suggests the involvement of intermediary factors not as readily available in the epidermis as they are in the follicle.
T4498 7053-7056 DT denotes The
T4499 7057-7061 NN denotes fact
T4500 7170-7178 VBZ denotes suggests
T4501 7062-7066 IN denotes that
T4502 7133-7140 VBN denotes altered
T4503 7067-7070 DT denotes the
T4504 7080-7088 NN denotes membrane
T4505 7071-7079 NN denotes basement
T4506 7089-7099 VBG denotes separating
T4507 7100-7103 DT denotes the
T4508 7104-7113 NN denotes epidermis
T4509 7114-7118 IN denotes from
T4510 7119-7122 DT denotes the
T4511 7123-7129 NN denotes dermis
T4512 7130-7132 VBZ denotes is
T4513 7141-7145 RB denotes only
T4514 7146-7148 IN denotes in
T4515 7149-7152 DT denotes the
T4516 7162-7169 NNS denotes animals
T4517 7153-7158 JJ denotes adult
T4518 7159-7161 NN denotes Tg
T4519 7179-7182 DT denotes the
T4520 7183-7194 NN denotes involvement
T4521 7195-7197 IN denotes of
T4522 7198-7210 JJ denotes intermediary
T4523 7211-7218 NNS denotes factors
T4524 7219-7222 RB denotes not
T4525 7234-7243 JJ denotes available
T4526 7223-7225 RB denotes as
T4527 7226-7233 RB denotes readily
T4528 7244-7246 IN denotes in
T4529 7247-7250 DT denotes the
T4530 7251-7260 NN denotes epidermis
T4531 7261-7263 IN denotes as
T4532 7269-7272 VBP denotes are
T4533 7264-7268 PRP denotes they
T4534 7273-7275 IN denotes in
T4535 7276-7279 DT denotes the
T4536 7280-7288 NN denotes follicle
T4537 7288-7289 . denotes .
R2289 T3910 T3911 amod Sustained,Expression
R2290 T3911 T3912 nsubj Expression,Results
R2291 T3913 T3911 prep of,Expression
R2292 T3914 T3913 pobj Snail,of
R2293 T3915 T3912 prep in,Results
R2294 T3916 T3917 amod Epidermal,Hyperproliferation
R2295 T3917 T3915 pobj Hyperproliferation,in
R2296 T3918 T3917 cc and,Hyperproliferation
R2297 T3919 T3920 compound Differentiation,Defects
R2298 T3920 T3917 conj Defects,Hyperproliferation
R2299 T3921 T3912 prep in,Results
R2300 T3922 T3923 compound Tg,Skin
R2301 T3923 T3921 pobj Skin,in
R2302 T3924 T3923 compound Mouse,Skin
R2303 T3926 T3927 det The,spike
R2304 T3927 T3929 nsubj spike,prompted
R2305 T3928 T3927 amod striking,spike
R2306 T3930 T3927 prep of,spike
R2307 T3931 T3932 compound Snail,expression
R2308 T3932 T3930 pobj expression,of
R2309 T3933 T3927 amod coincident,spike
R2310 T3934 T3933 prep with,coincident
R2311 T3935 T3936 compound hair,bud
R2312 T3936 T3937 compound bud,formation
R2313 T3937 T3934 pobj formation,with
R2314 T3938 T3937 cc and,formation
R2315 T3939 T3940 amod enhanced,proliferation
R2316 T3940 T3937 conj proliferation,formation
R2317 T3941 T3929 dobj us,prompted
R2318 T3942 T3943 aux to,examine
R2319 T3943 T3929 xcomp examine,prompted
R2320 T3944 T3945 det the,consequences
R2321 T3945 T3943 dobj consequences,examine
R2322 T3946 T3945 prep of,consequences
R2323 T3947 T3948 advmod ectopically,expressing
R2324 T3948 T3946 pcomp expressing,of
R2325 T3949 T3948 dobj Snail,expressing
R2326 T3950 T3948 advmod elsewhere,expressing
R2327 T3951 T3950 prep in,elsewhere
R2328 T3952 T3953 compound mouse,epidermis
R2329 T3953 T3951 pobj epidermis,in
R2330 T3954 T3953 compound skin,epidermis
R2331 T3955 T3929 punct .,prompted
R2332 T3957 T3958 aux To,distinguish
R2333 T3958 T3959 advcl distinguish,used
R2334 T3960 T3958 dobj Tg,distinguish
R2335 T3961 T3958 prep from,distinguish
R2336 T3962 T3963 amod endogenous,Snail
R2337 T3963 T3961 pobj Snail,from
R2338 T3964 T3959 punct ", ",used
R2339 T3965 T3959 nsubj we,used
R2340 T3966 T3967 det the,epitope
R2341 T3967 T3959 dobj epitope,used
R2342 T3968 T3967 compound HA,epitope
R2343 T3969 T3967 punct -,epitope
R2344 T3970 T3967 punct ", ",epitope
R2345 T3971 T3967 acl shown,epitope
R2346 T3972 T3971 advmod previously,shown
R2347 T3973 T3974 neg not,alter
R2348 T3974 T3971 xcomp alter,shown
R2349 T3975 T3974 aux to,alter
R2350 T3976 T3977 poss Snail,activity
R2351 T3977 T3974 dobj activity,alter
R2352 T3978 T3976 case 's,Snail
R2353 T3979 T3977 amod transcriptional,activity
R2354 T3980 T3981 punct [,12
R2355 T3981 T3959 parataxis 12,used
R2356 T3982 T3981 punct ],12
R2357 T3983 T3959 punct .,used
R2358 T3985 T3986 prep Of,expressed
R2359 T3987 T3988 nummod 20,animals
R2360 T3988 T3985 pobj animals,Of
R2361 T3989 T3990 nmod K14,Snail
R2362 T3990 T3988 nmod Snail,animals
R2363 T3991 T3990 punct -,Snail
R2364 T3992 T3988 punct [,animals
R2365 T3993 T3988 nmod HA,animals
R2366 T3994 T3988 punct ],animals
R2367 T3995 T3988 compound Tg,animals
R2368 T3996 T3988 acl generated,animals
R2369 T3997 T3986 punct ", ",expressed
R2370 T3998 T3986 nsubj three,expressed
R2371 T3999 T4000 det the,transgene
R2372 T4000 T3986 dobj transgene,expressed
R2373 T4001 T3986 cc and,expressed
R2374 T4002 T4003 nsubj all,exhibited
R2375 T4003 T3986 conj exhibited,expressed
R2376 T4004 T4005 amod analogous,phenotypes
R2377 T4005 T4003 dobj phenotypes,exhibited
R2378 T4006 T3986 punct .,expressed
R2379 T4008 T4009 nsubj Mice,died
R2380 T4010 T4011 dep that,integrated
R2381 T4011 T4008 relcl integrated,Mice
R2382 T4012 T4013 det the,transgene
R2383 T4013 T4011 dobj transgene,integrated
R2384 T4014 T4011 prep at,integrated
R2385 T4015 T4016 det the,stage
R2386 T4016 T4014 pobj stage,at
R2387 T4017 T4018 amod single,cell
R2388 T4018 T4016 compound cell,stage
R2389 T4019 T4018 punct -,cell
R2390 T4020 T4009 prep at,died
R2391 T4021 T4020 cc or,at
R2392 T4022 T4023 advmod shortly,after
R2393 T4023 T4020 conj after,at
R2394 T4024 T4023 pobj birth,after
R2395 T4025 T4009 punct .,died
R2396 T4027 T4028 det The,mice
R2397 T4028 T4035 nsubj mice,harbored
R2398 T4029 T4028 nummod three,mice
R2399 T4030 T4028 amod surviving,mice
R2400 T4031 T4032 amod full,Tg
R2401 T4032 T4028 compound Tg,mice
R2402 T4033 T4032 punct -,Tg
R2403 T4034 T4028 compound founder,mice
R2404 T4036 T4037 compound transgene,integrations
R2405 T4037 T4035 dobj integrations,harbored
R2406 T4038 T4039 dep that,gave
R2407 T4039 T4037 relcl gave,integrations
R2408 T4040 T4041 amod stable,transmission
R2409 T4041 T4039 dobj transmission,gave
R2410 T4042 T4041 prep of,transmission
R2411 T4043 T4044 amod mosaic,gene
R2412 T4044 T4046 compound gene,expression
R2413 T4045 T4044 compound Snail,gene
R2414 T4046 T4042 pobj expression,of
R2415 T4047 T4039 prep through,gave
R2416 T4048 T4049 det the,germline
R2417 T4049 T4047 pobj germline,through
R2418 T4050 T4035 punct .,harbored
R2419 T4052 T4053 advmod Progressively,poor
R2420 T4053 T4054 amod poor,health
R2421 T4054 T4055 nsubj health,necessitated
R2422 T4056 T4057 nsubj our,sacrificing
R2423 T4057 T4055 ccomp sacrificing,necessitated
R2424 T4058 T4059 amod most,offspring
R2425 T4059 T4057 dobj offspring,sacrificing
R2426 T4060 T4059 prep from,offspring
R2427 T4061 T4062 det these,lines
R2428 T4062 T4060 pobj lines,from
R2429 T4063 T4057 prep within,sacrificing
R2430 T4064 T4065 det a,year
R2431 T4065 T4063 pobj year,within
R2432 T4066 T4065 prep of,year
R2433 T4067 T4066 pobj birth,of
R2434 T4068 T4055 punct .,necessitated
R2435 T4070 T4071 mark As,grew
R2436 T4071 T4075 advcl grew,became
R2437 T4072 T4073 compound Snail,animals
R2438 T4073 T4071 nsubj animals,grew
R2439 T4074 T4073 compound Tg,animals
R2440 T4076 T4075 punct ", ",became
R2441 T4077 T4075 nsubj they,became
R2442 T4078 T4075 acomp distinguished,became
R2443 T4079 T4078 prep by,distinguished
R2444 T4080 T4081 poss their,size
R2445 T4081 T4079 pobj size,by
R2446 T4082 T4081 amod small,size
R2447 T4083 T4081 punct ", ",size
R2448 T4084 T4085 amod short,tails
R2449 T4085 T4081 conj tails,size
R2450 T4086 T4085 punct ", ",tails
R2451 T4087 T4085 cc and,tails
R2452 T4088 T4089 amod flaky,skin
R2453 T4089 T4085 conj skin,tails
R2454 T4090 T4091 punct (,2A
R2455 T4091 T4075 parataxis 2A,became
R2456 T4092 T4091 compound Figure,2A
R2457 T4093 T4091 punct ),2A
R2458 T4094 T4075 punct .,became
R2459 T4096 T4097 amod Histological,analyses
R2460 T4097 T4098 nsubj analyses,revealed
R2461 T4099 T4097 prep of,analyses
R2462 T4100 T4101 nummod 3,d
R2463 T4101 T4103 npadvmod d,old
R2464 T4102 T4101 punct -,d
R2465 T4103 T4104 amod old,mice
R2466 T4104 T4099 pobj mice,of
R2467 T4105 T4106 punct (,P3
R2468 T4106 T4103 parataxis P3,old
R2469 T4107 T4106 punct ),P3
R2470 T4108 T4109 compound mosaic,patches
R2471 T4109 T4098 dobj patches,revealed
R2472 T4110 T4109 acl marked,patches
R2473 T4111 T4110 agent by,marked
R2474 T4112 T4113 amod epidermal,thickening
R2475 T4113 T4111 pobj thickening,by
R2476 T4114 T4115 punct (,2B
R2477 T4115 T4098 parataxis 2B,revealed
R2478 T4116 T4115 compound Figure,2B
R2479 T4117 T4115 punct ),2B
R2480 T4118 T4098 punct .,revealed
R2481 T4120 T4121 det The,morphology
R2482 T4121 T4123 nsubjpass morphology,reflected
R2483 T4122 T4121 compound mosaic,morphology
R2484 T4124 T4123 auxpass was,reflected
R2485 T4125 T4123 prep at,reflected
R2486 T4126 T4127 det the,level
R2487 T4127 T4125 pobj level,at
R2488 T4128 T4127 prep of,level
R2489 T4129 T4130 compound Tg,protein
R2490 T4130 T4128 pobj protein,of
R2491 T4131 T4130 compound Snail,protein
R2492 T4132 T4123 punct ", ",reflected
R2493 T4133 T4134 mark with,expressing
R2494 T4134 T4123 advcl expressing,reflected
R2495 T4135 T4136 advmod only,regions
R2496 T4136 T4134 nsubj regions,expressing
R2497 T4137 T4136 det the,regions
R2498 T4138 T4136 amod hyperthickened,regions
R2499 T4139 T4140 amod nuclear,Snail
R2500 T4140 T4134 dobj Snail,expressing
R2501 T4141 T4142 npadvmod HA,tagged
R2502 T4142 T4140 amod tagged,Snail
R2503 T4143 T4142 punct -,tagged
R2504 T4144 T4145 punct (,2C
R2505 T4145 T4123 parataxis 2C,reflected
R2506 T4146 T4145 compound Figure,2C
R2507 T4147 T4145 punct ),2C
R2508 T4148 T4123 punct .,reflected
R2509 T4150 T4151 det These,areas
R2510 T4151 T4153 nsubjpass areas,marked
R2511 T4152 T4151 amod hyperthickened,areas
R2512 T4154 T4153 auxpass were,marked
R2513 T4155 T4153 agent by,marked
R2514 T4156 T4157 amod excessive,proliferation
R2515 T4157 T4155 pobj proliferation,by
R2516 T4158 T4153 punct ", ",marked
R2517 T4159 T4160 mark as,revealed
R2518 T4160 T4153 advcl revealed,marked
R2519 T4161 T4160 agent by,revealed
R2520 T4162 T4161 pobj antibodies,by
R2521 T4163 T4162 prep against,antibodies
R2522 T4164 T4165 det the,antigen
R2523 T4165 T4163 pobj antigen,against
R2524 T4166 T4165 amod proliferating,antigen
R2525 T4167 T4165 amod nuclear,antigen
R2526 T4168 T4165 appos Ki67,antigen
R2527 T4169 T4170 punct (,2D
R2528 T4170 T4153 parataxis 2D,marked
R2529 T4171 T4170 compound Figure,2D
R2530 T4172 T4170 cc and,2D
R2531 T4173 T4170 conj 2E,2D
R2532 T4174 T4170 punct ),2D
R2533 T4175 T4153 punct .,marked
R2534 T4177 T4178 amod Activated,cells
R2535 T4178 T4183 nsubj cells,were
R2536 T4179 T4178 punct ", ",cells
R2537 T4180 T4181 npadvmod pMAPK,positive
R2538 T4181 T4178 amod positive,cells
R2539 T4182 T4181 punct -,positive
R2540 T4184 T4183 advmod also,were
R2541 T4185 T4183 acomp prevalent,were
R2542 T4186 T4183 prep in,were
R2543 T4187 T4188 det these,areas
R2544 T4188 T4186 pobj areas,in
R2545 T4189 T4190 punct (,2F
R2546 T4190 T4183 parataxis 2F,were
R2547 T4191 T4190 compound Figure,2F
R2548 T4192 T4190 cc and,2F
R2549 T4193 T4190 conj 2G,2F
R2550 T4194 T4190 punct ),2F
R2551 T4195 T4183 punct ", ",were
R2552 T4196 T4197 mark as,were
R2553 T4197 T4183 advcl were,were
R2554 T4198 T4197 nsubj cells,were
R2555 T4199 T4198 acl expressing,cells
R2556 T4200 T4199 dobj keratin,expressing
R2557 T4201 T4200 nummod 6,keratin
R2558 T4202 T4200 punct ", ",keratin
R2559 T4203 T4204 det a,keratin
R2560 T4204 T4200 appos keratin,keratin
R2561 T4205 T4204 acl induced,keratin
R2562 T4206 T4205 prep in,induced
R2563 T4207 T4208 det the,layers
R2564 T4208 T4206 pobj layers,in
R2565 T4209 T4208 amod suprabasal,layers
R2566 T4210 T4208 prep of,layers
R2567 T4211 T4212 amod hyperproliferative,skin
R2568 T4212 T4210 pobj skin,of
R2569 T4213 T4214 punct (,2H
R2570 T4214 T4183 parataxis 2H,were
R2571 T4215 T4214 compound Figure,2H
R2572 T4216 T4214 cc and,2H
R2573 T4217 T4214 conj 2I,2H
R2574 T4218 T4214 punct ),2H
R2575 T4219 T4183 punct .,were
R2576 T4221 T4222 nsubj Expression,block
R2577 T4223 T4221 prep of,Expression
R2578 T4224 T4225 det the,transgene
R2579 T4225 T4223 pobj transgene,of
R2580 T4226 T4225 compound Snail,transgene
R2581 T4227 T4222 aux did,block
R2582 T4228 T4222 neg not,block
R2583 T4229 T4230 amod terminal,differentiation
R2584 T4230 T4222 dobj differentiation,block
R2585 T4231 T4222 prep in,block
R2586 T4232 T4233 det the,epidermis
R2587 T4233 T4231 pobj epidermis,in
R2588 T4234 T4233 amod hyperproliferative,epidermis
R2589 T4235 T4222 punct ", ",block
R2590 T4236 T4222 cc but,block
R2591 T4237 T4238 nsubj it,distorted
R2592 T4238 T4222 conj distorted,block
R2593 T4239 T4238 dobj it,distorted
R2594 T4240 T4238 advmod markedly,distorted
R2595 T4241 T4242 punct (,3A
R2596 T4242 T4238 parataxis 3A,distorted
R2597 T4243 T4242 compound Figure,3A
R2598 T4244 T4245 punct –,3H
R2599 T4245 T4242 prep 3H,3A
R2600 T4246 T4242 punct ),3A
R2601 T4247 T4238 punct .,distorted
R2602 T4249 T4250 advcl Typical,led
R2603 T4251 T4249 prep of,Typical
R2604 T4252 T4253 amod most,conditions
R2605 T4253 T4251 pobj conditions,of
R2606 T4254 T4253 compound hyperproliferating,conditions
R2607 T4255 T4250 punct ", ",led
R2608 T4256 T4257 compound Snail,expression
R2609 T4257 T4250 nsubj expression,led
R2610 T4258 T4250 prep to,led
R2611 T4259 T4260 det a,expansion
R2612 T4260 T4258 pobj expansion,to
R2613 T4261 T4260 amod large,expansion
R2614 T4262 T4250 prep in,led
R2615 T4263 T4262 pobj layers,in
R2616 T4264 T4263 prep with,layers
R2617 T4265 T4266 amod spinous,morphology
R2618 T4266 T4264 pobj morphology,with
R2619 T4267 T4265 cc and,spinous
R2620 T4268 T4265 conj granular,spinous
R2621 T4269 T4250 punct .,led
R2622 T4271 T4272 advmod Additionally,was
R2623 T4273 T4272 punct ", ",was
R2624 T4274 T4272 advmod however,was
R2625 T4275 T4272 punct ", ",was
R2626 T4276 T4277 det a,expansion
R2627 T4277 T4272 attr expansion,was
R2628 T4278 T4277 amod marked,expansion
R2629 T4279 T4278 cc and,marked
R2630 T4280 T4278 conj variable,marked
R2631 T4281 T4277 prep of,expansion
R2632 T4282 T4281 pobj keratin,of
R2633 T4283 T4282 nummod 5,keratin
R2634 T4284 T4282 punct (,keratin
R2635 T4285 T4282 appos K5,keratin
R2636 T4286 T4282 punct ),keratin
R2637 T4287 T4282 punct ", ",keratin
R2638 T4288 T4289 advmod normally,restricted
R2639 T4289 T4282 acl restricted,keratin
R2640 T4290 T4289 prep to,restricted
R2641 T4291 T4292 det the,layer
R2642 T4292 T4290 pobj layer,to
R2643 T4293 T4292 amod innermost,layer
R2644 T4294 T4292 amod basal,layer
R2645 T4295 T4296 punct (,see
R2646 T4296 T4272 parataxis see,was
R2647 T4297 T4296 dobj Figure,see
R2648 T4298 T4297 nummod 3,Figure
R2649 T4299 T4296 punct ),see
R2650 T4300 T4272 punct .,was
R2651 T4302 T4303 mark Although,precluded
R2652 T4303 T4318 advcl precluded,emerged
R2653 T4304 T4305 det the,failure
R2654 T4305 T4303 nsubj failure,precluded
R2655 T4306 T4305 prep of,failure
R2656 T4307 T4308 nmod Snail,mice
R2657 T4308 T4306 pobj mice,of
R2658 T4309 T4307 punct -,Snail
R2659 T4310 T4307 amod null,Snail
R2660 T4311 T4312 aux to,develop
R2661 T4312 T4305 acl develop,failure
R2662 T4313 T4314 amod past,gastrulation
R2663 T4314 T4312 dobj gastrulation,develop
R2664 T4315 T4316 punct [,21
R2665 T4316 T4305 parataxis 21,failure
R2666 T4317 T4316 punct ],21
R2667 T4319 T4320 poss our,ability
R2668 T4320 T4303 dobj ability,precluded
R2669 T4321 T4322 aux to,study
R2670 T4322 T4320 acl study,ability
R2671 T4323 T4324 det the,loss
R2672 T4324 T4322 dobj loss,study
R2673 T4325 T4324 prep of,loss
R2674 T4326 T4327 compound Snail,function
R2675 T4327 T4325 pobj function,of
R2676 T4328 T4324 prep in,loss
R2677 T4329 T4330 compound skin,development
R2678 T4330 T4328 pobj development,in
R2679 T4331 T4318 punct ", ",emerged
R2680 T4332 T4333 det a,correlation
R2681 T4333 T4318 nsubj correlation,emerged
R2682 T4334 T4333 amod good,correlation
R2683 T4335 T4318 prep between,emerged
R2684 T4336 T4337 det the,expression
R2685 T4337 T4335 pobj expression,between
R2686 T4338 T4337 prep of,expression
R2687 T4339 T4340 compound Snail,protein
R2688 T4340 T4338 pobj protein,of
R2689 T4341 T4337 cc and,expression
R2690 T4342 T4343 det the,extension
R2691 T4343 T4337 conj extension,expression
R2692 T4344 T4343 prep of,extension
R2693 T4345 T4344 pobj K5,of
R2694 T4346 T4345 punct ", ",K5
R2695 T4347 T4345 conj Ki67,K5
R2696 T4348 T4347 punct ", ",Ki67
R2697 T4349 T4347 cc and,Ki67
R2698 T4350 T4347 conj pMAPK,Ki67
R2699 T4351 T4343 advmod suprabasally,extension
R2700 T4352 T4353 punct (,compare
R2701 T4353 T4318 parataxis compare,emerged
R2702 T4354 T4353 dobj data,compare
R2703 T4355 T4353 prep in,compare
R2704 T4356 T4357 nmod Figures,2
R2705 T4357 T4355 pobj 2,in
R2706 T4358 T4357 cc and,2
R2707 T4359 T4357 conj 3,2
R2708 T4360 T4353 punct ),compare
R2709 T4361 T4318 punct .,emerged
R2710 T4363 T4364 det The,changes
R2711 T4364 T4365 nsubjpass changes,accompanied
R2712 T4366 T4364 prep in,changes
R2713 T4367 T4366 pobj hyperproliferation,in
R2714 T4368 T4367 cc and,hyperproliferation
R2715 T4369 T4367 conj differentiation,hyperproliferation
R2716 T4370 T4365 auxpass were,accompanied
R2717 T4371 T4365 neg not,accompanied
R2718 T4372 T4365 advmod initially,accompanied
R2719 T4373 T4365 agent by,accompanied
R2720 T4374 T4375 amod gross,signs
R2721 T4375 T4373 pobj signs,by
R2722 T4376 T4375 prep of,signs
R2723 T4377 T4378 amod epithelial,invaginations
R2724 T4378 T4376 pobj invaginations,of
R2725 T4379 T4365 punct .,accompanied
R2726 T4381 T4382 prep With,developed
R2727 T4383 T4381 pobj age,With
R2728 T4384 T4382 punct ", ",developed
R2729 T4385 T4382 advmod however,developed
R2730 T4386 T4382 punct ", ",developed
R2731 T4387 T4388 amod epidermal,folds
R2732 T4388 T4382 nsubj folds,developed
R2733 T4389 T4388 cc and,folds
R2734 T4390 T4388 conj undulations,folds
R2735 T4391 T4382 prep in,developed
R2736 T4392 T4391 pobj areas,in
R2737 T4393 T4394 advmod where,expressed
R2738 T4394 T4392 relcl expressed,areas
R2739 T4395 T4394 nsubjpass Snail,expressed
R2740 T4396 T4394 auxpass was,expressed
R2741 T4397 T4382 punct ", ",developed
R2742 T4398 T4382 cc and,developed
R2743 T4399 T4400 amod proliferative,markers
R2744 T4400 T4401 nsubj markers,persisted
R2745 T4401 T4382 conj persisted,developed
R2746 T4402 T4401 prep in,persisted
R2747 T4403 T4404 det these,regions
R2748 T4404 T4402 pobj regions,in
R2749 T4405 T4406 punct (,staining
R2750 T4406 T4401 parataxis staining,persisted
R2751 T4407 T4408 compound Figure,3I
R2752 T4408 T4406 dep 3I,staining
R2753 T4409 T4408 cc and,3I
R2754 T4410 T4408 conj 3J,3I
R2755 T4411 T4406 punct ;,staining
R2756 T4412 T4413 amod anti-cyclin,D
R2757 T4413 T4406 compound D,staining
R2758 T4414 T4406 punct ),staining
R2759 T4415 T4382 punct .,developed
R2760 T4417 T4418 det The,undulations
R2761 T4418 T4419 nsubjpass undulations,accompanied
R2762 T4420 T4419 auxpass were,accompanied
R2763 T4421 T4419 agent by,accompanied
R2764 T4422 T4423 amod partial,dissolution
R2765 T4423 T4421 pobj dissolution,by
R2766 T4424 T4423 prep of,dissolution
R2767 T4425 T4426 det the,membrane
R2768 T4426 T4424 pobj membrane,of
R2769 T4427 T4426 amod underlying,membrane
R2770 T4428 T4426 compound basement,membrane
R2771 T4429 T4430 punct (,3K
R2772 T4430 T4419 parataxis 3K,accompanied
R2773 T4431 T4430 compound Figure,3K
R2774 T4432 T4430 cc and,3K
R2775 T4433 T4430 conj 3L,3K
R2776 T4434 T4430 punct ),3K
R2777 T4435 T4419 punct .,accompanied
R2778 T4437 T4438 amod Aberrant,staining
R2779 T4438 T4439 nsubjpass staining,observed
R2780 T4440 T4439 auxpass was,observed
R2781 T4441 T4439 advmod also,observed
R2782 T4442 T4439 prep with,observed
R2783 T4443 T4442 pobj antibodies,with
R2784 T4444 T4443 prep against,antibodies
R2785 T4445 T4444 pobj components,against
R2786 T4446 T4445 prep of,components
R2787 T4447 T4448 det the,hemidesmosomes
R2788 T4448 T4446 pobj hemidesmosomes,of
R2789 T4449 T4445 punct ", ",components
R2790 T4450 T4451 dep which,provide
R2791 T4451 T4445 relcl provide,components
R2792 T4452 T4453 amod strong,adhesion
R2793 T4453 T4451 dobj adhesion,provide
R2794 T4454 T4453 prep of,adhesion
R2795 T4455 T4456 amod basal,cells
R2796 T4456 T4454 pobj cells,of
R2797 T4457 T4456 amod epidermal,cells
R2798 T4458 T4451 prep to,provide
R2799 T4459 T4460 det the,lamina
R2800 T4460 T4458 pobj lamina,to
R2801 T4461 T4460 amod underlying,lamina
R2802 T4462 T4460 amod basal,lamina
R2803 T4463 T4464 punct (,3M
R2804 T4464 T4439 parataxis 3M,observed
R2805 T4465 T4464 compound Figure,3M
R2806 T4466 T4464 cc and,3M
R2807 T4467 T4464 conj 3N,3M
R2808 T4468 T4464 punct ),3M
R2809 T4469 T4439 punct .,observed
R2810 T4471 T4472 advmod Interestingly,occur
R2811 T4473 T4472 punct ", ",occur
R2812 T4474 T4475 amod similar,types
R2813 T4475 T4472 nsubj types,occur
R2814 T4476 T4475 prep of,types
R2815 T4477 T4476 pobj alterations,of
R2816 T4478 T4472 prep in,occur
R2817 T4479 T4480 det the,membrane
R2818 T4480 T4478 pobj membrane,in
R2819 T4481 T4480 compound basement,membrane
R2820 T4482 T4472 prep in,occur
R2821 T4483 T4484 det the,bud
R2822 T4484 T4482 pobj bud,in
R2823 T4485 T4484 compound hair,bud
R2824 T4486 T4484 prep of,bud
R2825 T4487 T4488 amod embryonic,mice
R2826 T4488 T4486 pobj mice,of
R2827 T4489 T4487 cc and,embryonic
R2828 T4490 T4487 conj newborn,embryonic
R2829 T4491 T4492 advmod when,expressed
R2830 T4492 T4472 advcl expressed,occur
R2831 T4493 T4492 nsubjpass Snail,expressed
R2832 T4494 T4492 auxpass is,expressed
R2833 T4495 T4492 advmod normally,expressed
R2834 T4496 T4472 punct .,occur
R2835 T4498 T4499 det The,fact
R2836 T4499 T4500 nsubj fact,suggests
R2837 T4501 T4502 mark that,altered
R2838 T4502 T4499 acl altered,fact
R2839 T4503 T4504 det the,membrane
R2840 T4504 T4502 nsubjpass membrane,altered
R2841 T4505 T4504 compound basement,membrane
R2842 T4506 T4504 acl separating,membrane
R2843 T4507 T4508 det the,epidermis
R2844 T4508 T4506 dobj epidermis,separating
R2845 T4509 T4506 prep from,separating
R2846 T4510 T4511 det the,dermis
R2847 T4511 T4509 pobj dermis,from
R2848 T4512 T4502 auxpass is,altered
R2849 T4513 T4514 advmod only,in
R2850 T4514 T4502 prep in,altered
R2851 T4515 T4516 det the,animals
R2852 T4516 T4514 pobj animals,in
R2853 T4517 T4516 amod adult,animals
R2854 T4518 T4516 compound Tg,animals
R2855 T4519 T4520 det the,involvement
R2856 T4520 T4500 dobj involvement,suggests
R2857 T4521 T4520 prep of,involvement
R2858 T4522 T4523 amod intermediary,factors
R2859 T4523 T4521 pobj factors,of
R2860 T4524 T4525 neg not,available
R2861 T4525 T4523 relcl available,factors
R2862 T4526 T4527 advmod as,readily
R2863 T4527 T4525 advmod readily,available
R2864 T4528 T4525 prep in,available
R2865 T4529 T4530 det the,epidermis
R2866 T4530 T4528 pobj epidermis,in
R2867 T4531 T4532 mark as,are
R2868 T4532 T4525 advcl are,available
R2869 T4533 T4532 nsubj they,are
R2870 T4534 T4532 prep in,are
R2871 T4535 T4536 det the,follicle
R2872 T4536 T4534 pobj follicle,in
R2873 T4537 T4500 punct .,suggests