PMC:539061 / 14872-15642 JSONTXT

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    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T2504","span":{"begin":37,"end":47},"obj":"GO:0042571"},{"id":"T2505","span":{"begin":60,"end":73},"obj":"GO:0008283"},{"id":"T2506","span":{"begin":74,"end":81},"obj":"GO:0005634"},{"id":"T2507","span":{"begin":82,"end":89},"obj":"CHEBI:59132"},{"id":"T2508","span":{"begin":90,"end":94},"obj":"PR:000010425"},{"id":"T2509","span":{"begin":110,"end":115},"obj":"PR:000015308"},{"id":"T2510","span":{"begin":116,"end":126},"obj":"GO:0010467"},{"id":"T2511","span":{"begin":198,"end":211},"obj":"GO:0008283"},{"id":"T2512","span":{"begin":267,"end":277},"obj":"GO:0042571"},{"id":"T2513","span":{"begin":358,"end":371},"obj":"GO:0008283"},{"id":"T2514","span":{"begin":373,"end":377},"obj":"PR:000010425"},{"id":"T2515","span":{"begin":441,"end":445},"obj":"UBERON:0001037"},{"id":"T2516","span":{"begin":477,"end":482},"obj":"PR:000015308"},{"id":"T2517","span":{"begin":497,"end":501},"obj":"PR:000010425"},{"id":"T2518","span":{"begin":530,"end":534},"obj":"UBERON:0001037"},{"id":"T2519","span":{"begin":583,"end":588},"obj":"PR:000009751"},{"id":"T2520","span":{"begin":589,"end":598},"obj":"PR:000002198"},{"id":"T2521","span":{"begin":634,"end":646},"obj":"UBERON:0005086"},{"id":"T2522","span":{"begin":683,"end":687},"obj":"UBERON:0001037"},{"id":"T2523","span":{"begin":703,"end":721},"obj":"_FRAGMENT"},{"id":"T2524","span":{"begin":733,"end":743},"obj":"GO:0010629"},{"id":"T2525","span":{"begin":722,"end":732},"obj":"PR:000001447"}],"relations":[{"id":"R1424","pred":"_lexicallyChainedTo","subj":"T2524","obj":"T2523"}],"text":"As judged by immunofluorescence with antibodies against the proliferating nuclear antigen Ki67, the timing of Snail expression coincided with the stage at which the developing follicle enhanced its proliferation and down-growth (Figure 1F). Immunohistochemistry with antibodies against the active (phosphorylated) form of MAPK (pMAPK) marked a subset of the proliferating (Ki67-positive) cells, and pMAPK-positive cells were enriched in the hair bud (Figure 1G). The timing of Snail induction and Ki67 and pMAPK enrichment in the hair bud appeared to follow closely the induction of LEF-1/β-catenin activity, known to initiate in the hair placode stage [20]. However, like placodes, hair buds exhibited down-regulation in E-cadherin expression (Figure 1H; see also [4])."}

    2_test

    {"project":"2_test","denotations":[{"id":"15630473-10498690-84810259","span":{"begin":654,"end":656},"obj":"10498690"},{"id":"15630473-12646922-84810260","span":{"begin":766,"end":767},"obj":"12646922"},{"id":"T93454","span":{"begin":654,"end":656},"obj":"10498690"},{"id":"T72430","span":{"begin":766,"end":767},"obj":"12646922"}],"text":"As judged by immunofluorescence with antibodies against the proliferating nuclear antigen Ki67, the timing of Snail expression coincided with the stage at which the developing follicle enhanced its proliferation and down-growth (Figure 1F). Immunohistochemistry with antibodies against the active (phosphorylated) form of MAPK (pMAPK) marked a subset of the proliferating (Ki67-positive) cells, and pMAPK-positive cells were enriched in the hair bud (Figure 1G). The timing of Snail induction and Ki67 and pMAPK enrichment in the hair bud appeared to follow closely the induction of LEF-1/β-catenin activity, known to initiate in the hair placode stage [20]. However, like placodes, hair buds exhibited down-regulation in E-cadherin expression (Figure 1H; see also [4])."}

    craft-ca-core-ex-dev

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    craft-sa-dev

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