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PMC:539061 / 1322-3521 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T88 76-80 UBERON:0001037 denotes hair
T571 318-327 NCBITaxon:40674 denotes Mammalian
T572 353-366 GO:0009653 denotes morphogenesis
T573 499-511 _FRAGMENT denotes formation of
T574 517-523 GO:0048513 denotes organs
T575 517-523 UBERON:0000062 denotes organs
T576 535-540 UBERON:0002048 denotes lungs
T577 542-553 UBERON:0002240 denotes spinal cord
T578 555-569 UBERON:0001911 denotes mammary glands
T579 575-589 UBERON:0002073 denotes hair follicles
T580 621-631 UBERON:0000483 denotes epithelial
T581 621-637 CL:0000066 denotes epithelial cells
T582 710-726 UBERON:0010136 denotes epithelial sheet
T583 761-771 UBERON:0003104 denotes mesenchyme
T584 781-794 GO:0009653 denotes morphogenesis
T585 849-859 UBERON:0000483 denotes epithelium
T586 864-874 UBERON:0003104 denotes mesenchyme
T587 906-911 UBERON:0000062 denotes organ
T588 934-940 GO:0065007 denotes govern
T589 1017-1042 PR:000000034 denotes bone morphogenic proteins
T590 1044-1048 PR:000000034 denotes BMPs
T591 1051-1080 PR:000000046 denotes transforming growth factor βs
T592 1082-1088 PR:000000046 denotes TGF-βs
T593 1095-1105 CL:0000057 denotes fibroblast
T594 1151-1163 GO:0009986 denotes cell surface
T595 1169-1177 GO:0016020 denotes membrane
T596 1195-1203 GO:0005576 denotes external
T597 1204-1223 CHEBI:62488 denotes signaling molecules
T598 1241-1273 GO:0035556 denotes cascades of intracellular events
T599 1253-1266 GO:0005622 denotes intracellular
T600 1303-1307 SO:0000704 denotes gene
T601 1303-1318 GO:0010467 denotes gene expression
T602 1465-1478 GO:0009653 denotes morphogenetic
T603 1680-1689 CHEBI:35224 denotes effectors
T604 1866-1882 UBERON:0010136 denotes epithelial sheet
T605 1938-1951 _FRAGMENT denotes proliferation
T606 1987-1989 _FRAGMENT denotes of
T607 1999-2004 GO:0008283 denotes cells
T608 2074-2087 GO:0005576 denotes extracellular
T609 2088-2098 UBERON:0000483 denotes epithelial
T610 2099-2110 UBERON:0003104 denotes mesenchymal
T611 2168-2184 _FRAGMENT denotes determination of
R215 T574 T573 _lexicallyChainedTo organs,formation of
R216 T606 T605 _lexicallyChainedTo of,proliferation
R217 T607 T606 _lexicallyChainedTo cells,of

2_test

Id Subject Object Predicate Lexical cue
15630473-9988217-84810234 591-592 9988217 denotes 1
15630473-11841536-84810235 1349-1350 11841536 denotes 2
T56986 591-592 9988217 denotes 1
T26441 1349-1350 11841536 denotes 2

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T141 16-26 GO_EXT:0016015 denotes morphogens
T142 42-57 GO_EXT:transcription denotes transcriptional
T143 70-75 GO_EXT:biological_direction_or_guidance denotes guide
T144 76-80 UBERON:0001037 denotes hair
T145 117-121 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T744 318-327 NCBITaxon:40674 denotes Mammalian
T745 353-366 GO:0009653 denotes morphogenesis
T746 440-455 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes masses of cells
T747 450-455 CL_GO_EXT:cell denotes cells
T748 499-511 _FRAGMENT denotes formation of
T749 517-523 GO:0048513 denotes organs
T750 517-523 UBERON:0000062 denotes organs
T751 535-540 UBERON:0002048 denotes lungs
T752 542-553 UBERON:0002240 denotes spinal cord
T753 555-569 UBERON:0001911 denotes mammary glands
T754 575-589 UBERON:0002073 denotes hair follicles
T755 612-620 GO_PATO_EXT:biological_adhesion_or_attachedness denotes adhering
T756 621-631 UBERON:0000483 denotes epithelial
T757 621-637 CL:0000066 denotes epithelial cells
T758 632-637 CL_GO_EXT:cell denotes cells
T759 678-690 GO_UBERON_EXT:basal_lamina denotes basal lamina
T760 710-726 UBERON:0010136 denotes epithelial sheet
T761 761-771 UBERON:0003104 denotes mesenchyme
T762 781-794 GO:0009653 denotes morphogenesis
T763 798-804 GO_EXT:biological_direction_or_guidance denotes guided
T764 849-859 UBERON:0000483 denotes epithelium
T765 864-874 UBERON:0003104 denotes mesenchyme
T766 906-911 UBERON:0000062 denotes organ
T767 934-940 GO:0065007 denotes govern
T768 945-951 GO_EXT:biological_growth_entity_or_process denotes growth
T769 974-983 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T770 984-1006 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes communication pathways
T771 1017-1021 UBERON_EXT:bone_element_or_tissue denotes bone
T772 1017-1042 PR_EXT:000000034 denotes bone morphogenic proteins
T773 1022-1033 GO_EXT:0016015 denotes morphogenic
T774 1034-1042 CHEBI_PR_EXT:protein denotes proteins
T775 1044-1048 PR_EXT:000000034 denotes BMPs
T776 1051-1080 PR_EXT:000000046 denotes transforming growth factor βs
T777 1064-1070 GO_EXT:biological_growth_entity_or_process denotes growth
T778 1064-1077 GO_EXT:0008083 denotes growth factor
T779 1082-1088 PR_EXT:000000046 denotes TGF-βs
T780 1095-1105 CL:0000057 denotes fibroblast
T781 1106-1112 GO_EXT:biological_growth_entity_or_process denotes growth
T782 1106-1120 GO_EXT:0008083 denotes growth factors
T783 1151-1155 CL_GO_EXT:cell denotes cell
T784 1151-1163 GO:0009986 denotes cell surface
T785 1169-1177 GO:0016020 denotes membrane
T786 1178-1187 GO_EXT:0004872 denotes receptors
T787 1195-1203 GO:0005576 denotes external
T788 1204-1213 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T789 1204-1223 CHEBI_EXT:62488 denotes signaling molecules
T790 1241-1273 GO:0035556 denotes cascades of intracellular events
T791 1253-1266 GO:0005622 denotes intracellular
T792 1258-1266 CL_GO_EXT:cell denotes cellular
T793 1303-1307 SO_EXT:0000704 denotes gene
T794 1303-1318 GO:0010467 denotes gene expression
T795 1320-1326 GO_EXT:biological_growth_entity_or_process denotes growth
T796 1332-1347 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T797 1465-1478 GO:0009653 denotes morphogenetic
T798 1561-1570 GO_PATO_EXT:biological_patterning_process_or_quality denotes patterned
T799 1680-1689 CHEBI_EXT:35224 denotes effectors
T800 1726-1730 CL_GO_EXT:cell denotes cell
T801 1825-1833 GO_PATO_EXT:biological_behavior denotes behavior
T802 1850-1855 CL_GO_EXT:cell denotes cells
T803 1866-1882 UBERON:0010136 denotes epithelial sheet
T805 1987-1989 _FRAGMENT denotes of
T806 1999-2004 GO:0008283 denotes cells
T807 1999-2004 CL_GO_EXT:cell denotes cells
T808 2054-2066 GO_UBERON_EXT:basal_lamina denotes basal lamina
T809 2074-2087 GO:0005576 denotes extracellular
T810 2079-2087 CL_GO_EXT:cell denotes cellular
T811 2088-2098 UBERON:0000483 denotes epithelial
T812 2099-2110 UBERON:0003104 denotes mesenchymal
T813 2168-2184 _FRAGMENT denotes determination of
T815 2194-2198 CL_GO_EXT:cell denotes cell
T804 1938-1951 _FRAGMENT denotes proliferation
R220 T749 T748 _lexicallyChainedTo organs,formation of
R221 T805 T804 _lexicallyChainedTo of,proliferation
R222 T806 T805 _lexicallyChainedTo cells,of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T359 3-5 IN denotes of
T360 6-15 JJ denotes different
T361 16-26 NNS denotes morphogens
T362 27-30 CC denotes and
T363 31-41 JJ denotes downstream
T364 58-64 NNS denotes events
T365 42-57 JJ denotes transcriptional
T366 65-69 WDT denotes that
T367 70-75 VBP denotes guide
T368 76-80 NN denotes hair
T369 81-84 NN denotes bud
T370 85-94 NN denotes formation
T371 95-101 IN denotes within
T372 102-105 DT denotes the
T373 117-121 NN denotes skin
T374 106-116 VBG denotes developing
T375 121-122 . denotes .
T1019 318-327 JJ denotes Mammalian
T1020 328-339 NN denotes development
T1021 340-348 VBZ denotes involves
T1022 349-352 DT denotes the
T1023 353-366 NN denotes morphogenesis
T1024 367-369 IN denotes of
T1025 370-377 JJ denotes complex
T1026 396-406 NNS denotes structures
T1027 378-383 CD denotes three
T1028 384-395 JJ denotes dimensional
T1029 383-384 HYPH denotes -
T1030 407-411 IN denotes from
T1031 412-421 RB denotes seemingly
T1032 422-429 JJ denotes uniform
T1033 430-436 NNS denotes sheets
T1034 437-439 CC denotes or
T1035 440-446 NNS denotes masses
T1036 447-449 IN denotes of
T1037 450-455 NNS denotes cells
T1038 455-456 . denotes .
T1039 456-594 sentence denotes A simple bud-like structure initiates the formation of many organs, including lungs, spinal cord, mammary glands, and hair follicles [1].
T1040 457-458 DT denotes A
T1041 475-484 NN denotes structure
T1042 459-465 JJ denotes simple
T1043 466-469 NN denotes bud
T1044 470-474 JJ denotes like
T1045 469-470 HYPH denotes -
T1046 485-494 VBZ denotes initiates
T1047 495-498 DT denotes the
T1048 499-508 NN denotes formation
T1049 509-511 IN denotes of
T1050 512-516 JJ denotes many
T1051 517-523 NNS denotes organs
T1052 523-525 , denotes ,
T1053 525-534 VBG denotes including
T1054 535-540 NNS denotes lungs
T1055 540-542 , denotes ,
T1056 542-548 JJ denotes spinal
T1057 549-553 NN denotes cord
T1058 553-555 , denotes ,
T1059 555-562 JJ denotes mammary
T1060 563-569 NNS denotes glands
T1061 569-571 , denotes ,
T1062 571-574 CC denotes and
T1063 575-579 NN denotes hair
T1064 580-589 NNS denotes follicles
T1065 590-591 -LRB- denotes [
T1066 591-592 CD denotes 1
T1067 592-593 -RRB- denotes ]
T1068 593-594 . denotes .
T1069 594-772 sentence denotes The multipotent, adhering epithelial cells are typically attached to an underlying basal lamina that polarizes the epithelial sheet and separates it from surrounding mesenchyme.
T1070 595-598 DT denotes The
T1071 632-637 NNS denotes cells
T1072 599-610 JJ denotes multipotent
T1073 610-612 , denotes ,
T1074 612-620 VBG denotes adhering
T1075 621-631 JJ denotes epithelial
T1076 652-660 VBN denotes attached
T1077 638-641 VBP denotes are
T1078 642-651 RB denotes typically
T1079 661-663 IN denotes to
T1080 664-666 DT denotes an
T1081 684-690 NN denotes lamina
T1082 667-677 VBG denotes underlying
T1083 678-683 JJ denotes basal
T1084 691-695 WDT denotes that
T1085 696-705 VBZ denotes polarizes
T1086 706-709 DT denotes the
T1087 721-726 NN denotes sheet
T1088 710-720 JJ denotes epithelial
T1089 727-730 CC denotes and
T1090 731-740 VBZ denotes separates
T1091 741-743 PRP denotes it
T1092 744-748 IN denotes from
T1093 749-760 VBG denotes surrounding
T1094 761-771 NN denotes mesenchyme
T1095 771-772 . denotes .
T1096 772-952 sentence denotes Budding morphogenesis is guided by a reciprocal exchange of signals between epithelium and mesenchyme to specify the identity of the organ that will form and to govern its growth.
T1097 773-780 VBG denotes Budding
T1098 781-794 NN denotes morphogenesis
T1099 798-804 VBN denotes guided
T1100 795-797 VBZ denotes is
T1101 805-807 IN denotes by
T1102 808-809 DT denotes a
T1103 821-829 NN denotes exchange
T1104 810-820 JJ denotes reciprocal
T1105 830-832 IN denotes of
T1106 833-840 NNS denotes signals
T1107 841-848 IN denotes between
T1108 849-859 NN denotes epithelium
T1109 860-863 CC denotes and
T1110 864-874 NN denotes mesenchyme
T1111 875-877 TO denotes to
T1112 878-885 VB denotes specify
T1113 886-889 DT denotes the
T1114 890-898 NN denotes identity
T1115 899-901 IN denotes of
T1116 902-905 DT denotes the
T1117 906-911 NN denotes organ
T1118 912-916 WDT denotes that
T1119 922-926 VB denotes form
T1120 917-921 MD denotes will
T1121 927-930 CC denotes and
T1122 931-933 TO denotes to
T1123 934-940 VB denotes govern
T1124 941-944 PRP$ denotes its
T1125 945-951 NN denotes growth
T1126 951-952 . denotes .
T1127 952-1128 sentence denotes At the helm of these molecular communication pathways are Wnts, bone morphogenic proteins (BMPs), transforming growth factor βs (TGF-βs), and fibroblast growth factors (FGFs).
T1128 953-955 IN denotes At
T1129 1007-1010 VBP denotes are
T1130 956-959 DT denotes the
T1131 960-964 NN denotes helm
T1132 965-967 IN denotes of
T1133 968-973 DT denotes these
T1134 998-1006 NNS denotes pathways
T1135 974-983 JJ denotes molecular
T1136 984-997 NN denotes communication
T1137 1011-1015 NNS denotes Wnts
T1138 1015-1017 , denotes ,
T1139 1017-1021 NN denotes bone
T1140 1034-1042 NN denotes proteins
T1141 1022-1033 JJ denotes morphogenic
T1142 1043-1044 -LRB- denotes (
T1143 1044-1048 NNS denotes BMPs
T1144 1048-1049 -RRB- denotes )
T1145 1049-1051 , denotes ,
T1146 1051-1063 VBG denotes transforming
T1147 1078-1080 NNS denotes βs
T1148 1064-1070 NN denotes growth
T1149 1071-1077 NN denotes factor
T1150 1081-1082 -LRB- denotes (
T1151 1082-1085 NN denotes TGF
T1152 1086-1088 NNS denotes βs
T1153 1085-1086 HYPH denotes -
T1154 1088-1089 -RRB- denotes )
T1155 1089-1091 , denotes ,
T1156 1091-1094 CC denotes and
T1157 1095-1105 NN denotes fibroblast
T1158 1113-1120 NNS denotes factors
T1159 1106-1112 NN denotes growth
T1160 1121-1122 -LRB- denotes (
T1161 1122-1126 NNS denotes FGFs
T1162 1126-1127 -RRB- denotes )
T1163 1127-1128 . denotes .
T1164 1128-1352 sentence denotes Through activation of cell surface transmembrane receptors, these external signaling molecules trigger distinct cascades of intracellular events that culminate in changes in gene expression, growth, and differentiation [2].
T1165 1129-1136 IN denotes Through
T1166 1224-1231 VBP denotes trigger
T1167 1137-1147 NN denotes activation
T1168 1148-1150 IN denotes of
T1169 1151-1155 NN denotes cell
T1170 1156-1163 NN denotes surface
T1171 1178-1187 NNS denotes receptors
T1172 1164-1177 NN denotes transmembrane
T1173 1187-1189 , denotes ,
T1174 1189-1194 DT denotes these
T1175 1214-1223 NNS denotes molecules
T1176 1195-1203 JJ denotes external
T1177 1204-1213 NN denotes signaling
T1178 1232-1240 JJ denotes distinct
T1179 1241-1249 NNS denotes cascades
T1180 1250-1252 IN denotes of
T1181 1253-1266 JJ denotes intracellular
T1182 1267-1273 NNS denotes events
T1183 1274-1278 WDT denotes that
T1184 1279-1288 VBP denotes culminate
T1185 1289-1291 IN denotes in
T1186 1292-1299 NNS denotes changes
T1187 1300-1302 IN denotes in
T1188 1303-1307 NN denotes gene
T1189 1308-1318 NN denotes expression
T1190 1318-1320 , denotes ,
T1191 1320-1326 NN denotes growth
T1192 1326-1328 , denotes ,
T1193 1328-1331 CC denotes and
T1194 1332-1347 NN denotes differentiation
T1195 1348-1349 -LRB- denotes [
T1196 1349-1350 CD denotes 2
T1197 1350-1351 -RRB- denotes ]
T1198 1351-1352 . denotes .
T1199 1352-1525 sentence denotes How this constellation of signals collaborates in tailoring each budding process so that it executes a distinct morphogenetic program has yet to be comprehensively defined.
T1200 1353-1356 WRB denotes How
T1201 1387-1399 VBZ denotes collaborates
T1202 1357-1361 DT denotes this
T1203 1362-1375 NN denotes constellation
T1204 1376-1378 IN denotes of
T1205 1379-1386 NNS denotes signals
T1206 1487-1490 VBZ denotes has
T1207 1400-1402 IN denotes in
T1208 1403-1412 VBG denotes tailoring
T1209 1413-1417 DT denotes each
T1210 1426-1433 NN denotes process
T1211 1418-1425 NN denotes budding
T1212 1434-1436 IN denotes so
T1213 1445-1453 VBZ denotes executes
T1214 1437-1441 IN denotes that
T1215 1442-1444 PRP denotes it
T1216 1454-1455 DT denotes a
T1217 1479-1486 NN denotes program
T1218 1456-1464 JJ denotes distinct
T1219 1465-1478 JJ denotes morphogenetic
T1220 1491-1494 RB denotes yet
T1221 1517-1524 VBN denotes defined
T1222 1495-1497 TO denotes to
T1223 1498-1500 VB denotes be
T1224 1501-1516 RB denotes comprehensively
T1225 1524-1525 . denotes .
T1226 1525-1751 sentence denotes However, the process appears to be patterned at the initial stages of bud formation, since the relative importance of these pathways and their downstream effectors differ as buds begin to develop and cell fates are specified.
T1227 1526-1533 RB denotes However
T1228 1547-1554 VBZ denotes appears
T1229 1533-1535 , denotes ,
T1230 1535-1538 DT denotes the
T1231 1539-1546 NN denotes process
T1232 1555-1557 TO denotes to
T1233 1561-1570 VBN denotes patterned
T1234 1558-1560 VB denotes be
T1235 1571-1573 IN denotes at
T1236 1574-1577 DT denotes the
T1237 1586-1592 NNS denotes stages
T1238 1578-1585 JJ denotes initial
T1239 1593-1595 IN denotes of
T1240 1596-1599 NN denotes bud
T1241 1600-1609 NN denotes formation
T1242 1609-1611 , denotes ,
T1243 1611-1616 IN denotes since
T1244 1690-1696 VBP denotes differ
T1245 1617-1620 DT denotes the
T1246 1630-1640 NN denotes importance
T1247 1621-1629 JJ denotes relative
T1248 1641-1643 IN denotes of
T1249 1644-1649 DT denotes these
T1250 1650-1658 NNS denotes pathways
T1251 1659-1662 CC denotes and
T1252 1663-1668 PRP$ denotes their
T1253 1680-1689 NNS denotes effectors
T1254 1669-1679 JJ denotes downstream
T1255 1697-1699 IN denotes as
T1256 1705-1710 VBP denotes begin
T1257 1700-1704 NNS denotes buds
T1258 1711-1713 TO denotes to
T1259 1714-1721 VB denotes develop
T1260 1722-1725 CC denotes and
T1261 1726-1730 NN denotes cell
T1262 1731-1736 NNS denotes fates
T1263 1741-1750 VBN denotes specified
T1264 1737-1740 VBP denotes are
T1265 1750-1751 . denotes .
T1266 1751-1883 sentence denotes The development of a bud requires a number of coordinated changes in the behavior of the targeted cells within an epithelial sheet.
T1267 1752-1755 DT denotes The
T1268 1756-1767 NN denotes development
T1269 1777-1785 VBZ denotes requires
T1270 1768-1770 IN denotes of
T1271 1771-1772 DT denotes a
T1272 1773-1776 NN denotes bud
T1273 1786-1787 DT denotes a
T1274 1788-1794 NN denotes number
T1275 1795-1797 IN denotes of
T1276 1798-1809 VBN denotes coordinated
T1277 1810-1817 NNS denotes changes
T1278 1818-1820 IN denotes in
T1279 1821-1824 DT denotes the
T1280 1825-1833 NN denotes behavior
T1281 1834-1836 IN denotes of
T1282 1837-1840 DT denotes the
T1283 1850-1855 NNS denotes cells
T1284 1841-1849 VBN denotes targeted
T1285 1856-1862 IN denotes within
T1286 1863-1865 DT denotes an
T1287 1877-1882 NN denotes sheet
T1288 1866-1876 JJ denotes epithelial
T1289 1882-1883 . denotes .
T1290 1883-2067 sentence denotes The process must be accompanied by alterations in the proliferation, polarity, shape, and adhesiveness of selected cells, as well as by modifications in their underlying basal lamina.
T1291 1884-1887 DT denotes The
T1292 1888-1895 NN denotes process
T1293 1904-1915 VBN denotes accompanied
T1294 1896-1900 MD denotes must
T1295 1901-1903 VB denotes be
T1296 1916-1918 IN denotes by
T1297 1919-1930 NNS denotes alterations
T1298 1931-1933 IN denotes in
T1299 1934-1937 DT denotes the
T1300 1938-1951 NN denotes proliferation
T1301 1951-1953 , denotes ,
T1302 1953-1961 NN denotes polarity
T1303 1961-1963 , denotes ,
T1304 1963-1968 NN denotes shape
T1305 1968-1970 , denotes ,
T1306 1970-1973 CC denotes and
T1307 1974-1986 NN denotes adhesiveness
T1308 1987-1989 IN denotes of
T1309 1990-1998 VBN denotes selected
T1310 1999-2004 NNS denotes cells
T1311 2004-2006 , denotes ,
T1312 2006-2008 RB denotes as
T1313 2014-2016 IN denotes as
T1314 2009-2013 RB denotes well
T1315 2017-2019 IN denotes by
T1316 2020-2033 NNS denotes modifications
T1317 2034-2036 IN denotes in
T1318 2037-2042 PRP$ denotes their
T1319 2060-2066 NN denotes lamina
T1320 2043-2053 VBG denotes underlying
T1321 2054-2059 JJ denotes basal
T1322 2066-2067 . denotes .
T1324 2068-2072 RB denotes Thus
T1325 2141-2153 VBN denotes orchestrated
T1326 2072-2074 , denotes ,
T1327 2074-2087 JJ denotes extracellular
T1328 2111-2120 NN denotes crosstalk
T1329 2088-2098 JJ denotes epithelial
T1330 2099-2110 JJ denotes mesenchymal
T1331 2098-2099 HYPH denotes -
T1332 2121-2125 MD denotes must
T1333 2126-2128 VB denotes be
T1334 2129-2140 RB denotes intricately
T1335 2154-2156 TO denotes to
T1336 2157-2163 VB denotes couple
T1337 2164-2167 DT denotes the
T1338 2168-2181 NN denotes determination
T1339 2182-2184 IN denotes of
T1340 2185-2193 JJ denotes distinct
T1342 2194-2198 NN denotes cell
R202 T364 T361 conj events,morphogens
R203 T365 T364 amod transcriptional,events
R211 T373 T371 pobj skin,within
R212 T374 T373 amod developing,skin
R227 T1019 T1020 amod Mammalian,development
R228 T1020 T1021 nsubj development,involves
R229 T1022 T1023 det the,morphogenesis
R230 T1023 T1021 dobj morphogenesis,involves
R231 T1024 T1023 prep of,morphogenesis
R232 T1025 T1026 amod complex,structures
R233 T1026 T1024 pobj structures,of
R234 T1027 T1028 advmod three,dimensional
R235 T1028 T1026 amod dimensional,structures
R236 T1029 T1028 punct -,dimensional
R237 T1030 T1023 prep from,morphogenesis
R238 T1031 T1032 advmod seemingly,uniform
R239 T1032 T1033 amod uniform,sheets
R240 T1033 T1030 pobj sheets,from
R241 T1034 T1033 cc or,sheets
R242 T1035 T1033 conj masses,sheets
R243 T1036 T1033 prep of,sheets
R244 T1037 T1036 pobj cells,of
R245 T1038 T1021 punct .,involves
R246 T1040 T1041 det A,structure
R247 T1041 T1046 nsubj structure,initiates
R248 T1042 T1041 amod simple,structure
R249 T1043 T1044 npadvmod bud,like
R250 T1044 T1041 amod like,structure
R251 T1045 T1044 punct -,like
R252 T1047 T1048 det the,formation
R253 T1048 T1046 dobj formation,initiates
R254 T1049 T1048 prep of,formation
R255 T1050 T1051 amod many,organs
R256 T1051 T1049 pobj organs,of
R257 T1052 T1051 punct ", ",organs
R258 T1053 T1051 prep including,organs
R259 T1054 T1053 pobj lungs,including
R260 T1055 T1054 punct ", ",lungs
R261 T1056 T1057 amod spinal,cord
R262 T1057 T1054 conj cord,lungs
R263 T1058 T1057 punct ", ",cord
R264 T1059 T1060 amod mammary,glands
R265 T1060 T1057 conj glands,cord
R266 T1061 T1060 punct ", ",glands
R267 T1062 T1060 cc and,glands
R268 T1063 T1064 compound hair,follicles
R269 T1064 T1060 conj follicles,glands
R270 T1065 T1066 punct [,1
R271 T1066 T1046 parataxis 1,initiates
R272 T1067 T1066 punct ],1
R273 T1068 T1046 punct .,initiates
R274 T1070 T1071 det The,cells
R275 T1071 T1076 nsubjpass cells,attached
R276 T1072 T1071 amod multipotent,cells
R277 T1073 T1071 punct ", ",cells
R278 T1074 T1071 amod adhering,cells
R279 T1075 T1071 amod epithelial,cells
R280 T1077 T1076 auxpass are,attached
R281 T1078 T1076 advmod typically,attached
R282 T1079 T1076 prep to,attached
R283 T1080 T1081 det an,lamina
R284 T1081 T1079 pobj lamina,to
R285 T1082 T1081 amod underlying,lamina
R286 T1083 T1081 amod basal,lamina
R287 T1084 T1085 dep that,polarizes
R288 T1085 T1081 relcl polarizes,lamina
R289 T1086 T1087 det the,sheet
R290 T1087 T1085 dobj sheet,polarizes
R291 T1088 T1087 amod epithelial,sheet
R292 T1089 T1085 cc and,polarizes
R293 T1090 T1085 conj separates,polarizes
R294 T1091 T1090 dobj it,separates
R295 T1092 T1090 prep from,separates
R296 T1093 T1094 amod surrounding,mesenchyme
R297 T1094 T1092 pobj mesenchyme,from
R298 T1095 T1076 punct .,attached
R299 T1097 T1098 amod Budding,morphogenesis
R300 T1098 T1099 nsubjpass morphogenesis,guided
R301 T1100 T1099 auxpass is,guided
R302 T1101 T1099 agent by,guided
R303 T1102 T1103 det a,exchange
R304 T1103 T1101 pobj exchange,by
R305 T1104 T1103 amod reciprocal,exchange
R306 T1105 T1103 prep of,exchange
R307 T1106 T1105 pobj signals,of
R308 T1107 T1103 prep between,exchange
R309 T1108 T1107 pobj epithelium,between
R310 T1109 T1108 cc and,epithelium
R311 T1110 T1108 conj mesenchyme,epithelium
R312 T1111 T1112 aux to,specify
R313 T1112 T1103 advcl specify,exchange
R314 T1113 T1114 det the,identity
R315 T1114 T1112 dobj identity,specify
R316 T1115 T1114 prep of,identity
R317 T1116 T1117 det the,organ
R318 T1117 T1115 pobj organ,of
R319 T1118 T1119 dep that,form
R320 T1119 T1117 relcl form,organ
R321 T1120 T1119 aux will,form
R322 T1121 T1112 cc and,specify
R323 T1122 T1123 aux to,govern
R324 T1123 T1112 conj govern,specify
R325 T1124 T1125 poss its,growth
R326 T1125 T1123 dobj growth,govern
R327 T1126 T1099 punct .,guided
R328 T1128 T1129 prep At,are
R329 T1130 T1131 det the,helm
R330 T1131 T1128 pobj helm,At
R331 T1132 T1131 prep of,helm
R332 T1133 T1134 det these,pathways
R333 T1134 T1132 pobj pathways,of
R334 T1135 T1136 amod molecular,communication
R335 T1136 T1134 compound communication,pathways
R336 T1137 T1129 nsubj Wnts,are
R337 T1138 T1137 punct ", ",Wnts
R338 T1139 T1140 nmod bone,proteins
R339 T1140 T1137 appos proteins,Wnts
R340 T1141 T1140 amod morphogenic,proteins
R341 T1142 T1140 punct (,proteins
R342 T1143 T1140 appos BMPs,proteins
R343 T1144 T1137 punct ),Wnts
R344 T1145 T1137 punct ", ",Wnts
R345 T1146 T1147 amod transforming,βs
R346 T1147 T1137 appos βs,Wnts
R347 T1148 T1147 compound growth,βs
R348 T1149 T1147 compound factor,βs
R349 T1150 T1147 punct (,βs
R350 T1151 T1152 compound TGF,βs
R351 T1152 T1147 appos βs,βs
R352 T1153 T1152 punct -,βs
R353 T1154 T1137 punct ),Wnts
R354 T1155 T1137 punct ", ",Wnts
R355 T1156 T1137 cc and,Wnts
R356 T1157 T1158 compound fibroblast,factors
R357 T1158 T1137 conj factors,Wnts
R358 T1159 T1158 compound growth,factors
R359 T1160 T1158 punct (,factors
R360 T1161 T1158 appos FGFs,factors
R361 T1162 T1129 punct ),are
R362 T1163 T1129 punct .,are
R363 T1165 T1166 prep Through,trigger
R364 T1167 T1165 pobj activation,Through
R365 T1168 T1167 prep of,activation
R366 T1169 T1170 compound cell,surface
R367 T1170 T1171 compound surface,receptors
R368 T1171 T1168 pobj receptors,of
R369 T1172 T1171 compound transmembrane,receptors
R370 T1173 T1166 punct ", ",trigger
R371 T1174 T1175 det these,molecules
R372 T1175 T1166 nsubj molecules,trigger
R373 T1176 T1175 amod external,molecules
R374 T1177 T1175 compound signaling,molecules
R375 T1178 T1179 amod distinct,cascades
R376 T1179 T1166 dobj cascades,trigger
R377 T1180 T1179 prep of,cascades
R378 T1181 T1182 amod intracellular,events
R379 T1182 T1180 pobj events,of
R380 T1183 T1184 dep that,culminate
R381 T1184 T1179 relcl culminate,cascades
R382 T1185 T1184 prep in,culminate
R383 T1186 T1185 pobj changes,in
R384 T1187 T1186 prep in,changes
R385 T1188 T1189 compound gene,expression
R386 T1189 T1187 pobj expression,in
R387 T1190 T1189 punct ", ",expression
R388 T1191 T1189 conj growth,expression
R389 T1192 T1191 punct ", ",growth
R390 T1193 T1191 cc and,growth
R391 T1194 T1191 conj differentiation,growth
R392 T1195 T1196 punct [,2
R393 T1196 T1166 parataxis 2,trigger
R394 T1197 T1196 punct ],2
R395 T1198 T1166 punct .,trigger
R396 T1200 T1201 advmod How,collaborates
R397 T1201 T1206 csubj collaborates,has
R398 T1202 T1203 det this,constellation
R399 T1203 T1201 nsubj constellation,collaborates
R400 T1204 T1203 prep of,constellation
R401 T1205 T1204 pobj signals,of
R402 T1207 T1201 prep in,collaborates
R403 T1208 T1207 pcomp tailoring,in
R404 T1209 T1210 det each,process
R405 T1210 T1208 dobj process,tailoring
R406 T1211 T1210 compound budding,process
R407 T1212 T1213 mark so,executes
R408 T1213 T1208 advcl executes,tailoring
R409 T1214 T1213 mark that,executes
R410 T1215 T1213 nsubj it,executes
R411 T1216 T1217 det a,program
R412 T1217 T1213 dobj program,executes
R413 T1218 T1217 amod distinct,program
R414 T1219 T1217 amod morphogenetic,program
R415 T1220 T1221 advmod yet,defined
R416 T1221 T1206 xcomp defined,has
R417 T1222 T1221 aux to,defined
R418 T1223 T1221 auxpass be,defined
R419 T1224 T1221 advmod comprehensively,defined
R420 T1225 T1206 punct .,has
R421 T1227 T1228 advmod However,appears
R422 T1229 T1228 punct ", ",appears
R423 T1230 T1231 det the,process
R424 T1231 T1228 nsubj process,appears
R425 T1232 T1233 aux to,patterned
R426 T1233 T1228 xcomp patterned,appears
R427 T1234 T1233 auxpass be,patterned
R428 T1235 T1233 prep at,patterned
R429 T1236 T1237 det the,stages
R430 T1237 T1235 pobj stages,at
R431 T1238 T1237 amod initial,stages
R432 T1239 T1237 prep of,stages
R433 T1240 T1241 compound bud,formation
R434 T1241 T1239 pobj formation,of
R435 T1242 T1228 punct ", ",appears
R436 T1243 T1244 mark since,differ
R437 T1244 T1228 advcl differ,appears
R438 T1245 T1246 det the,importance
R439 T1246 T1244 nsubj importance,differ
R440 T1247 T1246 amod relative,importance
R441 T1248 T1246 prep of,importance
R442 T1249 T1250 det these,pathways
R443 T1250 T1248 pobj pathways,of
R444 T1251 T1250 cc and,pathways
R445 T1252 T1253 poss their,effectors
R446 T1253 T1250 conj effectors,pathways
R447 T1254 T1253 amod downstream,effectors
R448 T1255 T1256 mark as,begin
R449 T1256 T1244 advcl begin,differ
R450 T1257 T1256 nsubj buds,begin
R451 T1258 T1259 aux to,develop
R452 T1259 T1256 xcomp develop,begin
R453 T1260 T1256 cc and,begin
R454 T1261 T1262 compound cell,fates
R455 T1262 T1263 nsubjpass fates,specified
R456 T1263 T1256 conj specified,begin
R457 T1264 T1263 auxpass are,specified
R458 T1265 T1228 punct .,appears
R459 T1267 T1268 det The,development
R460 T1268 T1269 nsubj development,requires
R461 T1270 T1268 prep of,development
R462 T1271 T1272 det a,bud
R463 T1272 T1270 pobj bud,of
R464 T1273 T1274 det a,number
R465 T1274 T1269 dobj number,requires
R466 T1275 T1274 prep of,number
R467 T1276 T1277 amod coordinated,changes
R468 T1277 T1275 pobj changes,of
R469 T1278 T1277 prep in,changes
R470 T1279 T1280 det the,behavior
R471 T1280 T1278 pobj behavior,in
R472 T1281 T1280 prep of,behavior
R473 T1282 T1283 det the,cells
R474 T1283 T1281 pobj cells,of
R475 T1284 T1283 amod targeted,cells
R476 T1285 T1280 prep within,behavior
R477 T1286 T1287 det an,sheet
R478 T1287 T1285 pobj sheet,within
R479 T1288 T1287 amod epithelial,sheet
R480 T1289 T1269 punct .,requires
R481 T1291 T1292 det The,process
R482 T1292 T1293 nsubjpass process,accompanied
R483 T1294 T1293 aux must,accompanied
R484 T1295 T1293 auxpass be,accompanied
R485 T1296 T1293 prep by,accompanied
R486 T1297 T1296 pobj alterations,by
R487 T1298 T1297 prep in,alterations
R488 T1299 T1300 det the,proliferation
R489 T1300 T1298 pobj proliferation,in
R490 T1301 T1300 punct ", ",proliferation
R491 T1302 T1300 conj polarity,proliferation
R492 T1303 T1302 punct ", ",polarity
R493 T1304 T1302 conj shape,polarity
R494 T1305 T1304 punct ", ",shape
R495 T1306 T1304 cc and,shape
R496 T1307 T1304 conj adhesiveness,shape
R497 T1308 T1300 prep of,proliferation
R498 T1309 T1310 amod selected,cells
R499 T1310 T1308 pobj cells,of
R500 T1311 T1296 punct ", ",by
R501 T1312 T1313 advmod as,as
R502 T1313 T1296 cc as,by
R503 T1314 T1313 advmod well,as
R504 T1315 T1296 conj by,by
R505 T1316 T1315 pobj modifications,by
R506 T1317 T1316 prep in,modifications
R507 T1318 T1319 poss their,lamina
R508 T1319 T1317 pobj lamina,in
R509 T1320 T1319 amod underlying,lamina
R510 T1321 T1319 amod basal,lamina
R511 T1322 T1293 punct .,accompanied
R512 T1324 T1325 advmod Thus,orchestrated
R513 T1326 T1325 punct ", ",orchestrated
R514 T1327 T1328 amod extracellular,crosstalk
R515 T1328 T1325 nsubjpass crosstalk,orchestrated
R516 T1329 T1330 amod epithelial,mesenchymal
R517 T1330 T1328 amod mesenchymal,crosstalk
R518 T1331 T1330 punct -,mesenchymal
R519 T1332 T1325 aux must,orchestrated
R520 T1333 T1325 auxpass be,orchestrated
R521 T1334 T1325 advmod intricately,orchestrated
R522 T1335 T1336 aux to,couple
R523 T1336 T1325 advcl couple,orchestrated
R524 T1337 T1338 det the,determination
R525 T1338 T1336 dobj determination,couple
R526 T1339 T1338 prep of,determination
R198 T360 T361 amod different,morphogens
R199 T361 T359 pobj morphogens,of
R200 T362 T361 cc and,morphogens
R201 T363 T364 amod downstream,events
R204 T366 T367 dep that,guide
R206 T368 T369 compound hair,bud
R207 T369 T370 compound bud,formation
R208 T370 T367 dobj formation,guide
R209 T371 T367 prep within,guide
R210 T372 T373 det the,skin