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PMC:539061 / 129-1444 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T69 21-34 GO:0048513 denotes organogenesis
T70 71-87 UBERON:0010136 denotes epithelial sheet
T71 166-170 UBERON:0001037 denotes hair
T72 175-188 GO:0009653 denotes morphogenesis
T73 223-228 NCBITaxon:10088 denotes mouse
T74 249-262 CL:0000312 denotes keratinocytes
T75 304-317 GO:0005576 denotes extracellular
T76 362-375 GO:0008283 denotes proliferation
T77 430-459 PR:000000183 denotes transforming growth factor β2
T78 530-535 PR:000015308 denotes Snail
T79 557-564 CHEBI:52290 denotes mitogen
T80 624-633 UBERON:0007376 denotes epidermis
T81 635-640 PR:000015308 denotes Snail
T82 644-654 GO:0010467 denotes expression
T83 669-682 GO:0008283 denotes proliferation
T84 731-741 PR:000001447 denotes E-cadherin
T85 859-877 GO:0005911 denotes cell-cell contacts
T86 923-938 GO:0000187 denotes MAPK activation
T87 1078-1091 GO:0008283 denotes proliferation
T88 1269-1273 UBERON:0001037 denotes hair

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T94 21-34 GO:0048513 denotes organogenesis
T95 44-49 CL_GO_EXT:cell denotes cells
T96 71-87 UBERON:0010136 denotes epithelial sheet
T97 166-170 UBERON:0001037 denotes hair
T98 175-188 GO:0009653 denotes morphogenesis
T99 216-222 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T100 223-228 NCBITaxon:10088 denotes mouse
T101 249-262 CL:0000312 denotes keratinocytes
T102 304-317 GO:0005576 denotes extracellular
T103 309-317 CL_GO_EXT:cell denotes cellular
T104 340-348 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T105 362-375 GO:0008283 denotes proliferation
T106 389-405 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes cluster of cells
T107 400-405 CL_GO_EXT:cell denotes cells
T108 430-459 PR_EXT:000000183 denotes transforming growth factor β2
T109 443-449 GO_EXT:biological_growth_entity_or_process denotes growth
T110 443-456 GO_EXT:0008083 denotes growth factor
T111 460-469 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T112 509-522 GO_EXT:transcription denotes transcription
T113 509-529 GO_EXT:transcription_factor denotes transcription factor
T114 530-535 PR_EXT:000015308 denotes Snail
T115 557-564 CHEBI_EXT:52290 denotes mitogen
T116 557-589 GO_PR_EXT:MAP_kinase denotes mitogen-activated protein kinase
T117 575-582 CHEBI_PR_EXT:protein denotes protein
T118 591-595 GO_PR_EXT:MAP_kinase denotes MAPK
T119 624-633 UBERON:0007376 denotes epidermis
T120 635-640 PR_EXT:000015308 denotes Snail
T121 644-654 GO:0010467 denotes expression
T122 669-682 GO:0008283 denotes proliferation
T123 707-715 CL_GO_EXT:cell denotes cellular
T124 716-724 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T125 731-741 PR_EXT:000001447 denotes E-cadherin
T126 745-762 GO_EXT:transcription denotes transcriptionally
T127 763-777 GO_EXT:negative_regulation denotes down-regulated
T128 790-798 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T129 799-807 CHEBI_PR_EXT:protein denotes proteins
T130 831-840 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T131 845-853 GO_EXT:biological_release denotes released
T132 859-877 GO:0005911 denotes cell-cell contacts
T133 859-863 _FRAGMENT denotes cell
T134 992-997 CL_GO_EXT:cell denotes cells
T135 864-868 CL_GO_EXT:cell denotes cell
T136 923-927 GO_PR_EXT:MAP_kinase denotes MAPK
T137 923-938 GO:0000187 denotes MAPK activation
T138 1039-1054 GO_EXT:transcription denotes transcriptional
T139 1078-1091 GO:0008283 denotes proliferation
T140 1146-1163 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling pathway
T141 1209-1219 GO_EXT:0016015 denotes morphogens
T142 1235-1250 GO_EXT:transcription denotes transcriptional
T143 1263-1268 GO_EXT:biological_direction_or_guidance denotes guide
T144 1269-1273 UBERON:0001037 denotes hair
T145 1310-1314 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
R1 T134 T133 _lexicallyChainedTo cells,cell

craft-sa-dev

Id Subject Object Predicate Lexical cue
T161 0-159 sentence denotes In a common theme of organogenesis, certain cells within a multipotent epithelial sheet exchange signals with their neighbors and develop into a bud structure.
T162 0-2 IN denotes In
T163 88-96 VB denotes exchange
T164 3-4 DT denotes a
T165 12-17 NN denotes theme
T166 5-11 JJ denotes common
T167 18-20 IN denotes of
T168 21-34 NN denotes organogenesis
T169 34-36 , denotes ,
T170 36-43 JJ denotes certain
T171 44-49 NNS denotes cells
T172 50-56 IN denotes within
T173 57-58 DT denotes a
T174 82-87 NN denotes sheet
T175 59-70 JJ denotes multipotent
T176 71-81 JJ denotes epithelial
T177 97-104 NNS denotes signals
T178 105-109 IN denotes with
T179 110-115 PRP$ denotes their
T180 116-125 NNS denotes neighbors
T181 126-129 CC denotes and
T182 130-137 VBP denotes develop
T183 138-142 IN denotes into
T184 143-144 DT denotes a
T185 149-158 NN denotes structure
T186 145-148 NN denotes bud
T187 158-159 . denotes .
T188 159-415 sentence denotes Using hair bud morphogenesis as a paradigm, we employed mutant mouse models and cultured keratinocytes to dissect the contributions of multiple extracellular cues in orchestrating adhesion dynamics and proliferation to shape the cluster of cells involved.
T189 160-165 VBG denotes Using
T190 207-215 VBD denotes employed
T191 166-170 NN denotes hair
T192 171-174 NN denotes bud
T193 175-188 NN denotes morphogenesis
T194 189-191 IN denotes as
T195 192-193 DT denotes a
T196 194-202 NN denotes paradigm
T197 202-204 , denotes ,
T198 204-206 PRP denotes we
T199 216-222 NN denotes mutant
T200 223-228 NN denotes mouse
T201 229-235 NNS denotes models
T202 236-239 CC denotes and
T203 240-248 VBN denotes cultured
T204 249-262 NNS denotes keratinocytes
T205 263-265 TO denotes to
T206 266-273 VB denotes dissect
T207 274-277 DT denotes the
T208 278-291 NNS denotes contributions
T209 292-294 IN denotes of
T210 295-303 JJ denotes multiple
T211 318-322 NNS denotes cues
T212 304-317 JJ denotes extracellular
T213 323-325 IN denotes in
T214 326-339 VBG denotes orchestrating
T215 340-348 NN denotes adhesion
T216 349-357 NNS denotes dynamics
T217 358-361 CC denotes and
T218 362-375 NN denotes proliferation
T219 376-378 TO denotes to
T220 379-384 VB denotes shape
T221 385-388 DT denotes the
T222 389-396 NN denotes cluster
T223 397-399 IN denotes of
T224 400-405 NNS denotes cells
T225 406-414 VBN denotes involved
T226 414-415 . denotes .
T227 415-616 sentence denotes We found that transforming growth factor β2 signaling is necessary to transiently induce the transcription factor Snail and activate the Ras-mitogen-activated protein kinase (MAPK) pathway in the bud.
T228 416-418 PRP denotes We
T229 419-424 VBD denotes found
T230 425-429 IN denotes that
T231 470-472 VBZ denotes is
T232 430-442 VBG denotes transforming
T233 443-449 NN denotes growth
T234 457-459 NN denotes β2
T235 450-456 NN denotes factor
T236 460-469 NN denotes signaling
T237 473-482 JJ denotes necessary
T238 483-485 TO denotes to
T239 498-504 VB denotes induce
T240 486-497 RB denotes transiently
T241 505-508 DT denotes the
T242 530-535 NN denotes Snail
T243 509-522 NN denotes transcription
T244 523-529 NN denotes factor
T245 536-539 CC denotes and
T246 540-548 VB denotes activate
T247 549-552 DT denotes the
T248 597-604 NN denotes pathway
T249 553-556 NN denotes Ras
T250 583-589 NN denotes kinase
T251 556-557 HYPH denotes -
T252 557-564 NN denotes mitogen
T253 565-574 VBN denotes activated
T254 564-565 HYPH denotes -
T255 575-582 NN denotes protein
T256 590-591 -LRB- denotes (
T257 591-595 NN denotes MAPK
T258 595-596 -RRB- denotes )
T259 605-607 IN denotes in
T260 608-611 DT denotes the
T261 612-615 NN denotes bud
T262 615-616 . denotes .
T263 616-725 sentence denotes In the epidermis, Snail misexpression leads to hyperproliferation and a reduction in intercellular adhesion.
T264 617-619 IN denotes In
T265 655-660 VBZ denotes leads
T266 620-623 DT denotes the
T267 624-633 NN denotes epidermis
T268 633-635 , denotes ,
T269 635-640 NN denotes Snail
T270 641-654 NN denotes misexpression
T271 661-663 IN denotes to
T272 664-682 NN denotes hyperproliferation
T273 683-686 CC denotes and
T274 687-688 DT denotes a
T275 689-698 NN denotes reduction
T276 699-701 IN denotes in
T277 702-715 JJ denotes intercellular
T278 716-724 NN denotes adhesion
T279 724-725 . denotes .
T280 725-939 sentence denotes When E-cadherin is transcriptionally down-regulated, associated adhesion proteins with dual functions in signaling are released from cell-cell contacts, a process which we demonstrate leads to Ras-MAPK activation.
T281 726-730 WRB denotes When
T282 768-777 VBN denotes regulated
T283 731-732 NN denotes E
T284 733-741 NN denotes cadherin
T285 732-733 HYPH denotes -
T286 742-744 VBZ denotes is
T287 745-762 RB denotes transcriptionally
T288 763-767 RB denotes down
T289 767-768 HYPH denotes -
T290 845-853 VBN denotes released
T291 777-779 , denotes ,
T292 779-789 VBN denotes associated
T293 799-807 NN denotes proteins
T294 790-798 NN denotes adhesion
T295 808-812 IN denotes with
T296 813-817 JJ denotes dual
T297 818-827 NNS denotes functions
T298 828-830 IN denotes in
T299 831-840 NN denotes signaling
T300 841-844 VBP denotes are
T301 854-858 IN denotes from
T302 859-863 NN denotes cell
T303 864-868 NN denotes cell
T304 863-864 HYPH denotes -
T305 869-877 NNS denotes contacts
T306 877-879 , denotes ,
T307 879-880 DT denotes a
T308 881-888 NN denotes process
T309 889-894 WDT denotes which
T310 898-909 VBP denotes demonstrate
T311 895-897 PRP denotes we
T312 910-915 VBZ denotes leads
T313 916-918 IN denotes to
T314 919-922 NN denotes Ras
T315 923-927 NN denotes MAPK
T316 922-923 HYPH denotes -
T317 928-938 NN denotes activation
T318 938-939 . denotes .
T319 939-1134 sentence denotes These studies provide insights into how multipotent cells within a sheet are stimulated to undergo transcriptional changes that result in proliferation, junctional remodeling, and bud formation.
T320 940-945 DT denotes These
T321 946-953 NNS denotes studies
T322 954-961 VBP denotes provide
T323 962-970 NNS denotes insights
T324 971-975 IN denotes into
T325 976-979 WRB denotes how
T326 1017-1027 VBN denotes stimulated
T327 980-991 JJ denotes multipotent
T328 992-997 NNS denotes cells
T329 998-1004 IN denotes within
T330 1005-1006 DT denotes a
T331 1007-1012 NN denotes sheet
T332 1013-1016 VBP denotes are
T333 1028-1030 TO denotes to
T334 1031-1038 VB denotes undergo
T335 1039-1054 JJ denotes transcriptional
T336 1055-1062 NNS denotes changes
T337 1063-1067 WDT denotes that
T338 1068-1074 VBP denotes result
T339 1075-1077 IN denotes in
T340 1078-1091 NN denotes proliferation
T341 1091-1093 , denotes ,
T342 1093-1103 JJ denotes junctional
T343 1104-1114 NN denotes remodeling
T344 1114-1116 , denotes ,
T345 1116-1119 CC denotes and
T346 1120-1123 NN denotes bud
T347 1124-1133 NN denotes formation
T348 1133-1134 . denotes .
T349 1134-1315 sentence denotes This novel signaling pathway further weaves together the web of different morphogens and downstream transcriptional events that guide hair bud formation within the developing skin.
T350 1135-1139 DT denotes This
T351 1156-1163 NN denotes pathway
T352 1140-1145 JJ denotes novel
T353 1146-1155 NN denotes signaling
T354 1172-1178 VBZ denotes weaves
T355 1164-1171 RB denotes further
T356 1179-1187 RP denotes together
T357 1188-1191 DT denotes the
T358 1192-1195 NN denotes web
T359 1196-1198 IN denotes of
T360 1199-1208 JJ denotes different
T361 1209-1219 NNS denotes morphogens
T362 1220-1223 CC denotes and
T363 1224-1234 JJ denotes downstream
T364 1251-1257 NNS denotes events
T365 1235-1250 JJ denotes transcriptional
T366 1258-1262 WDT denotes that
T367 1263-1268 VBP denotes guide
T368 1269-1273 NN denotes hair
T369 1274-1277 NN denotes bud
T370 1278-1287 NN denotes formation
T371 1288-1294 IN denotes within
T372 1295-1298 DT denotes the
T373 1310-1314 NN denotes skin
T374 1299-1309 VBG denotes developing
T375 1314-1315 . denotes .
R15 T165 T162 pobj theme,In
R16 T166 T165 amod common,theme
R24 T174 T172 pobj sheet,within
R25 T175 T174 amod multipotent,sheet
R26 T176 T174 amod epithelial,sheet
R35 T185 T183 pobj structure,into
R36 T186 T185 compound bud,structure
R59 T211 T209 pobj cues,of
R60 T212 T211 amod extracellular,cues
R77 T231 T229 ccomp is,found
R78 T232 T231 csubj transforming,is
R79 T233 T234 compound growth,β2
R81 T235 T234 compound factor,β2
R82 T236 T232 dobj signaling,transforming
R85 T239 T231 advcl induce,is
R86 T240 T239 advmod transiently,induce
R88 T242 T239 dobj Snail,induce
R89 T243 T242 compound transcription,Snail
R90 T244 T242 compound factor,Snail
R94 T248 T246 dobj pathway,activate
R95 T249 T250 nmod Ras,kinase
R96 T250 T248 nmod kinase,pathway
R97 T251 T250 punct -,kinase
R98 T252 T253 npadvmod mitogen,activated
R99 T253 T250 amod activated,kinase
R100 T254 T253 punct -,activated
R101 T255 T250 nmod protein,kinase
R102 T256 T250 punct (,kinase
R103 T257 T250 appos MAPK,kinase
R104 T258 T248 punct ),pathway
R125 T282 T290 advcl regulated,released
R126 T283 T284 compound E,cadherin
R128 T285 T284 punct -,cadherin
R129 T286 T282 auxpass is,regulated
R130 T287 T282 advmod transcriptionally,regulated
R131 T288 T282 advmod down,regulated
R132 T289 T282 punct -,regulated
R135 T293 T290 nsubjpass proteins,released
R136 T294 T293 compound adhesion,proteins
R145 T303 T305 compound cell,contacts
R146 T304 T303 punct -,cell
R152 T310 T308 relcl demonstrate,process
R153 T311 T310 nsubj we,demonstrate
R157 T315 T317 compound MAPK,activation
R158 T316 T315 punct -,MAPK
R166 T326 T324 pcomp stimulated,into
R167 T327 T328 amod multipotent,cells
R168 T328 T326 nsubjpass cells,stimulated
R169 T329 T328 prep within,cells
R170 T330 T331 det a,sheet
R171 T331 T329 pobj sheet,within
R172 T332 T326 auxpass are,stimulated
R190 T351 T354 nsubj pathway,weaves
R191 T352 T351 amod novel,pathway
R192 T353 T351 compound signaling,pathway
R202 T364 T361 conj events,morphogens
R203 T365 T364 amod transcriptional,events
R211 T373 T371 pobj skin,within
R212 T374 T373 amod developing,skin
R13 T162 T163 prep In,exchange
R14 T164 T165 det a,theme
R17 T167 T165 prep of,theme
R18 T168 T167 pobj organogenesis,of
R19 T169 T163 punct ", ",exchange
R20 T170 T171 amod certain,cells
R21 T171 T163 nsubj cells,exchange
R22 T172 T171 prep within,cells
R23 T173 T174 det a,sheet
R27 T177 T163 dobj signals,exchange
R28 T178 T163 prep with,exchange
R29 T179 T180 poss their,neighbors
R30 T180 T178 pobj neighbors,with
R31 T181 T163 cc and,exchange
R32 T182 T163 conj develop,exchange
R33 T183 T182 prep into,develop
R34 T184 T185 det a,structure
R37 T187 T163 punct .,exchange
R38 T189 T190 advcl Using,employed
R39 T191 T192 compound hair,bud
R40 T192 T193 compound bud,morphogenesis
R41 T193 T189 dobj morphogenesis,Using
R42 T194 T189 prep as,Using
R43 T195 T196 det a,paradigm
R44 T196 T194 pobj paradigm,as
R45 T197 T190 punct ", ",employed
R46 T198 T190 nsubj we,employed
R47 T199 T200 compound mutant,mouse
R48 T200 T201 compound mouse,models
R49 T201 T190 dobj models,employed
R50 T202 T201 cc and,models
R51 T203 T204 amod cultured,keratinocytes
R52 T204 T201 conj keratinocytes,models
R53 T205 T206 aux to,dissect
R54 T206 T190 advcl dissect,employed
R55 T207 T208 det the,contributions
R56 T208 T206 dobj contributions,dissect
R57 T209 T208 prep of,contributions
R58 T210 T211 amod multiple,cues
R61 T213 T208 prep in,contributions
R62 T214 T213 pcomp orchestrating,in
R63 T215 T216 compound adhesion,dynamics
R64 T216 T214 dobj dynamics,orchestrating
R65 T217 T216 cc and,dynamics
R66 T218 T216 conj proliferation,dynamics
R67 T219 T220 aux to,shape
R68 T220 T214 advcl shape,orchestrating
R69 T221 T222 det the,cluster
R70 T222 T220 dobj cluster,shape
R71 T223 T222 prep of,cluster
R72 T224 T223 pobj cells,of
R73 T225 T222 acl involved,cluster
R74 T226 T190 punct .,employed
R75 T228 T229 nsubj We,found
R76 T230 T231 mark that,is
R80 T234 T236 compound β2,signaling
R83 T237 T231 acomp necessary,is
R84 T238 T239 aux to,induce
R87 T241 T242 det the,Snail
R91 T245 T239 cc and,induce
R92 T246 T239 conj activate,induce
R93 T247 T248 det the,pathway
R105 T259 T246 prep in,activate
R106 T260 T261 det the,bud
R107 T261 T259 pobj bud,in
R108 T262 T229 punct .,found
R109 T264 T265 prep In,leads
R110 T266 T267 det the,epidermis
R111 T267 T264 pobj epidermis,In
R112 T268 T265 punct ", ",leads
R113 T269 T270 compound Snail,misexpression
R114 T270 T265 nsubj misexpression,leads
R115 T271 T265 prep to,leads
R116 T272 T271 pobj hyperproliferation,to
R117 T273 T272 cc and,hyperproliferation
R118 T274 T275 det a,reduction
R119 T275 T272 conj reduction,hyperproliferation
R120 T276 T275 prep in,reduction
R121 T277 T278 amod intercellular,adhesion
R122 T278 T276 pobj adhesion,in
R123 T279 T265 punct .,leads
R124 T281 T282 advmod When,regulated
R127 T284 T282 nsubjpass cadherin,regulated
R133 T291 T290 punct ", ",released
R134 T292 T293 amod associated,proteins
R137 T295 T293 prep with,proteins
R138 T296 T297 amod dual,functions
R139 T297 T295 pobj functions,with
R140 T298 T297 prep in,functions
R141 T299 T298 pobj signaling,in
R142 T300 T290 auxpass are,released
R143 T301 T290 prep from,released
R144 T302 T303 compound cell,cell
R147 T305 T301 pobj contacts,from
R148 T306 T290 punct ", ",released
R149 T307 T308 det a,process
R150 T308 T290 npadvmod process,released
R151 T309 T310 dep which,demonstrate
R154 T312 T310 advcl leads,demonstrate
R155 T313 T312 prep to,leads
R156 T314 T315 compound Ras,MAPK
R159 T317 T313 pobj activation,to
R160 T318 T290 punct .,released
R161 T320 T321 det These,studies
R162 T321 T322 nsubj studies,provide
R163 T323 T322 dobj insights,provide
R164 T324 T323 prep into,insights
R165 T325 T326 advmod how,stimulated
R173 T333 T334 aux to,undergo
R174 T334 T326 advcl undergo,stimulated
R175 T335 T336 amod transcriptional,changes
R176 T336 T334 dobj changes,undergo
R177 T337 T338 dep that,result
R178 T338 T336 relcl result,changes
R179 T339 T338 prep in,result
R180 T340 T339 pobj proliferation,in
R181 T341 T340 punct ", ",proliferation
R182 T342 T343 amod junctional,remodeling
R183 T343 T340 conj remodeling,proliferation
R184 T344 T343 punct ", ",remodeling
R185 T345 T343 cc and,remodeling
R186 T346 T347 compound bud,formation
R187 T347 T343 conj formation,remodeling
R188 T348 T322 punct .,provide
R189 T350 T351 det This,pathway
R193 T355 T354 advmod further,weaves
R194 T356 T354 prt together,weaves
R195 T357 T358 det the,web
R196 T358 T354 dobj web,weaves
R197 T359 T358 prep of,web
R198 T360 T361 amod different,morphogens
R199 T361 T359 pobj morphogens,of
R200 T362 T361 cc and,morphogens
R201 T363 T364 amod downstream,events
R204 T366 T367 dep that,guide
R205 T367 T358 relcl guide,web
R206 T368 T369 compound hair,bud
R207 T369 T370 compound bud,formation
R208 T370 T367 dobj formation,guide
R209 T371 T367 prep within,guide
R210 T372 T373 det the,skin
R213 T375 T354 punct .,weaves