PMC:5324983 / 4934-5730 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5324983","sourcedb":"PMC","sourceid":"5324983","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5324983","text":"Although skin and nervous system share a common ectodermal origin, between the third and fifth week of gestation the neural ectoderm separates from the cutaneous ectoderm (disjunction). It is worth observing that this is one of the most vulnerable stages in human development. With a complete separation of neural and cutaneous ectoderms, mesoderm inserts between these two layers to form the meninges, vertebral column, and muscles. In contrast, an incomplete separation results in abnormal development of the spinal cord with or without a persistent connection with the overlying skin, which may also produce abnormalities in the tissues derived from mesoderm and cutaneous ectoderm.5 Therefore, the association of SCD with neural tube defects and congenital hemangioma may not be coincidental.","tracks":[]}