PMC:529315 / 199-557 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/529315","sourcedb":"PMC","sourceid":"529315","source_url":"http://www.ncbi.nlm.nih.gov/pmc/529315","text":"roapoptotic gene Bax in NT-3 knockout mice rescues these neurons and allows for examination of their axon growth in the absence of NT-3 signaling. TrkC-positive peripheral and central axons from dorsal root ganglia follow proper trajectories and arrive in close proximity to their targets but fail to innervate them. Peripherally, muscle spindles are absent ","tracks":[{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T374","span":{"begin":2,"end":11},"obj":"GO_PATO_EXT:apoptotic_process_or_quality"},{"id":"T375","span":{"begin":12,"end":16},"obj":"SO_EXT:0000704"},{"id":"T376","span":{"begin":17,"end":20},"obj":"PR_EXT:000002193"},{"id":"T377","span":{"begin":24,"end":28},"obj":"PR_EXT:000011459"},{"id":"T378","span":{"begin":38,"end":42},"obj":"NCBITaxon:10088"},{"id":"T379","span":{"begin":43,"end":50},"obj":"SO_EXT:sequence_rescue_process"},{"id":"T380","span":{"begin":57,"end":64},"obj":"CL:0000540"},{"id":"T381","span":{"begin":101,"end":105},"obj":"GO:0030424"},{"id":"T382","span":{"begin":106,"end":112},"obj":"GO_EXT:biological_growth_entity_or_process"},{"id":"T383","span":{"begin":131,"end":135},"obj":"PR_EXT:000011459"},{"id":"T384","span":{"begin":136,"end":145},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T385","span":{"begin":147,"end":151},"obj":"PR_EXT:000011471"},{"id":"T386","span":{"begin":184,"end":189},"obj":"GO:0030424"},{"id":"T387","span":{"begin":195,"end":214},"obj":"UBERON:0000044"},{"id":"T388","span":{"begin":301,"end":310},"obj":"GO:0060384"},{"id":"T389","span":{"begin":331,"end":346},"obj":"UBERON:0003718"}],"attributes":[{"subj":"T374","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T375","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T376","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T377","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T378","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T379","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T380","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T381","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T382","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T383","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T384","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T385","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T386","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T387","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T388","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T389","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T337","span":{"begin":12,"end":16},"obj":"SO:0000704"},{"id":"T338","span":{"begin":17,"end":20},"obj":"PR:000002193"},{"id":"T339","span":{"begin":24,"end":28},"obj":"PR:000011459"},{"id":"T340","span":{"begin":38,"end":42},"obj":"NCBITaxon:10088"},{"id":"T341","span":{"begin":57,"end":64},"obj":"CL:0000540"},{"id":"T342","span":{"begin":101,"end":105},"obj":"GO:0030424"},{"id":"T343","span":{"begin":131,"end":135},"obj":"PR:000011459"},{"id":"T344","span":{"begin":147,"end":151},"obj":"PR:000011471"},{"id":"T345","span":{"begin":184,"end":189},"obj":"GO:0030424"},{"id":"T346","span":{"begin":195,"end":214},"obj":"UBERON:0000044"},{"id":"T347","span":{"begin":301,"end":310},"obj":"GO:0060384"},{"id":"T348","span":{"begin":331,"end":346},"obj":"UBERON:0003718"}],"attributes":[{"subj":"T337","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T338","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T339","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T340","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T341","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T342","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T343","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T344","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T345","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T346","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T347","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T348","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-sa-dev","denotations":[{"id":"T440","span":{"begin":43,"end":50},"obj":"VBZ"},{"id":"T443","span":{"begin":12,"end":16},"obj":"NN"},{"id":"T445","span":{"begin":17,"end":20},"obj":"NN"},{"id":"T446","span":{"begin":21,"end":23},"obj":"IN"},{"id":"T447","span":{"begin":24,"end":26},"obj":"NN"},{"id":"T448","span":{"begin":29,"end":37},"obj":"NN"},{"id":"T449","span":{"begin":26,"end":27},"obj":"HYPH"},{"id":"T450","span":{"begin":27,"end":28},"obj":"CD"},{"id":"T451","span":{"begin":38,"end":42},"obj":"NNS"},{"id":"T452","span":{"begin":51,"end":56},"obj":"DT"},{"id":"T453","span":{"begin":57,"end":64},"obj":"NNS"},{"id":"T454","span":{"begin":65,"end":68},"obj":"CC"},{"id":"T455","span":{"begin":69,"end":75},"obj":"VBZ"},{"id":"T456","span":{"begin":76,"end":79},"obj":"IN"},{"id":"T457","span":{"begin":80,"end":91},"obj":"NN"},{"id":"T458","span":{"begin":92,"end":94},"obj":"IN"},{"id":"T459","span":{"begin":95,"end":100},"obj":"PRP$"},{"id":"T460","span":{"begin":106,"end":112},"obj":"NN"},{"id":"T461","span":{"begin":101,"end":105},"obj":"NN"},{"id":"T462","span":{"begin":113,"end":115},"obj":"IN"},{"id":"T463","span":{"begin":116,"end":119},"obj":"DT"},{"id":"T464","span":{"begin":120,"end":127},"obj":"NN"},{"id":"T465","span":{"begin":128,"end":130},"obj":"IN"},{"id":"T466","span":{"begin":131,"end":133},"obj":"NN"},{"id":"T467","span":{"begin":136,"end":145},"obj":"NN"},{"id":"T468","span":{"begin":133,"end":134},"obj":"HYPH"},{"id":"T469","span":{"begin":134,"end":135},"obj":"CD"},{"id":"T470","span":{"begin":145,"end":146},"obj":"."},{"id":"T471","span":{"begin":146,"end":316},"obj":"sentence"},{"id":"T472","span":{"begin":147,"end":151},"obj":"NN"},{"id":"T473","span":{"begin":152,"end":160},"obj":"JJ"},{"id":"T474","span":{"begin":151,"end":152},"obj":"HYPH"},{"id":"T475","span":{"begin":184,"end":189},"obj":"NNS"},{"id":"T476","span":{"begin":161,"end":171},"obj":"JJ"},{"id":"T477","span":{"begin":172,"end":175},"obj":"CC"},{"id":"T478","span":{"begin":176,"end":183},"obj":"JJ"},{"id":"T479","span":{"begin":215,"end":221},"obj":"VBP"},{"id":"T480","span":{"begin":190,"end":194},"obj":"IN"},{"id":"T481","span":{"begin":195,"end":201},"obj":"JJ"},{"id":"T482","span":{"begin":202,"end":206},"obj":"NN"},{"id":"T483","span":{"begin":207,"end":214},"obj":"NNS"},{"id":"T484","span":{"begin":222,"end":228},"obj":"JJ"},{"id":"T485","span":{"begin":229,"end":241},"obj":"NNS"},{"id":"T486","span":{"begin":242,"end":245},"obj":"CC"},{"id":"T487","span":{"begin":246,"end":252},"obj":"VBP"},{"id":"T488","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T489","span":{"begin":256,"end":261},"obj":"JJ"},{"id":"T490","span":{"begin":262,"end":271},"obj":"NN"},{"id":"T491","span":{"begin":272,"end":274},"obj":"IN"},{"id":"T492","span":{"begin":275,"end":280},"obj":"PRP$"},{"id":"T493","span":{"begin":281,"end":288},"obj":"NNS"},{"id":"T494","span":{"begin":289,"end":292},"obj":"CC"},{"id":"T495","span":{"begin":293,"end":297},"obj":"VBP"},{"id":"T496","span":{"begin":298,"end":300},"obj":"TO"},{"id":"T497","span":{"begin":301,"end":310},"obj":"VB"},{"id":"T498","span":{"begin":311,"end":315},"obj":"PRP"},{"id":"T499","span":{"begin":315,"end":316},"obj":"."},{"id":"T501","span":{"begin":317,"end":329},"obj":"RB"},{"id":"T502","span":{"begin":347,"end":350},"obj":"VBP"},{"id":"T503","span":{"begin":329,"end":331},"obj":","},{"id":"T504","span":{"begin":331,"end":337},"obj":"NN"},{"id":"T505","span":{"begin":338,"end":346},"obj":"NNS"},{"id":"T506","span":{"begin":351,"end":357},"obj":"JJ"}],"relations":[{"id":"R16","pred":"appos","subj":"T445","obj":"T443"},{"id":"R18","pred":"nmod","subj":"T447","obj":"T448"},{"id":"R19","pred":"compound","subj":"T448","obj":"T451"},{"id":"R20","pred":"punct","subj":"T449","obj":"T447"},{"id":"R21","pred":"nummod","subj":"T450","obj":"T447"},{"id":"R22","pred":"pobj","subj":"T451","obj":"T446"},{"id":"R23","pred":"det","subj":"T452","obj":"T453"},{"id":"R24","pred":"dobj","subj":"T453","obj":"T440"},{"id":"R25","pred":"cc","subj":"T454","obj":"T440"},{"id":"R26","pred":"conj","subj":"T455","obj":"T440"},{"id":"R27","pred":"prep","subj":"T456","obj":"T455"},{"id":"R28","pred":"pobj","subj":"T457","obj":"T456"},{"id":"R29","pred":"prep","subj":"T458","obj":"T457"},{"id":"R30","pred":"poss","subj":"T459","obj":"T460"},{"id":"R31","pred":"pobj","subj":"T460","obj":"T458"},{"id":"R32","pred":"compound","subj":"T461","obj":"T460"},{"id":"R33","pred":"prep","subj":"T462","obj":"T455"},{"id":"R34","pred":"det","subj":"T463","obj":"T464"},{"id":"R35","pred":"pobj","subj":"T464","obj":"T462"},{"id":"R36","pred":"prep","subj":"T465","obj":"T464"},{"id":"R37","pred":"nmod","subj":"T466","obj":"T467"},{"id":"R38","pred":"pobj","subj":"T467","obj":"T465"},{"id":"R39","pred":"punct","subj":"T468","obj":"T466"},{"id":"R40","pred":"nummod","subj":"T469","obj":"T466"},{"id":"R41","pred":"punct","subj":"T470","obj":"T440"},{"id":"R42","pred":"npadvmod","subj":"T472","obj":"T473"},{"id":"R43","pred":"amod","subj":"T473","obj":"T475"},{"id":"R44","pred":"punct","subj":"T474","obj":"T473"},{"id":"R45","pred":"nsubj","subj":"T475","obj":"T479"},{"id":"R46","pred":"amod","subj":"T476","obj":"T475"},{"id":"R47","pred":"cc","subj":"T477","obj":"T476"},{"id":"R48","pred":"conj","subj":"T478","obj":"T476"},{"id":"R49","pred":"prep","subj":"T480","obj":"T475"},{"id":"R50","pred":"amod","subj":"T481","obj":"T482"},{"id":"R51","pred":"compound","subj":"T482","obj":"T483"},{"id":"R52","pred":"pobj","subj":"T483","obj":"T480"},{"id":"R53","pred":"amod","subj":"T484","obj":"T485"},{"id":"R54","pred":"dobj","subj":"T485","obj":"T479"},{"id":"R55","pred":"cc","subj":"T486","obj":"T479"},{"id":"R56","pred":"conj","subj":"T487","obj":"T479"},{"id":"R57","pred":"prep","subj":"T488","obj":"T487"},{"id":"R58","pred":"amod","subj":"T489","obj":"T490"},{"id":"R59","pred":"pobj","subj":"T490","obj":"T488"},{"id":"R60","pred":"prep","subj":"T491","obj":"T490"},{"id":"R61","pred":"poss","subj":"T492","obj":"T493"},{"id":"R62","pred":"pobj","subj":"T493","obj":"T491"},{"id":"R79","pred":"cc","subj":"T494","obj":"T479"},{"id":"R80","pred":"conj","subj":"T495","obj":"T479"},{"id":"R81","pred":"aux","subj":"T496","obj":"T497"},{"id":"R82","pred":"xcomp","subj":"T497","obj":"T495"},{"id":"R83","pred":"dobj","subj":"T498","obj":"T497"},{"id":"R84","pred":"punct","subj":"T499","obj":"T479"},{"id":"R85","pred":"advmod","subj":"T501","obj":"T502"},{"id":"R86","pred":"punct","subj":"T503","obj":"T502"},{"id":"R87","pred":"compound","subj":"T504","obj":"T505"},{"id":"R88","pred":"nsubj","subj":"T505","obj":"T502"},{"id":"R89","pred":"acomp","subj":"T506","obj":"T502"}],"attributes":[{"subj":"T440","pred":"source","obj":"craft-sa-dev"},{"subj":"T443","pred":"source","obj":"craft-sa-dev"},{"subj":"T445","pred":"source","obj":"craft-sa-dev"},{"subj":"T446","pred":"source","obj":"craft-sa-dev"},{"subj":"T447","pred":"source","obj":"craft-sa-dev"},{"subj":"T448","pred":"source","obj":"craft-sa-dev"},{"subj":"T449","pred":"source","obj":"craft-sa-dev"},{"subj":"T450","pred":"source","obj":"craft-sa-dev"},{"subj":"T451","pred":"source","obj":"craft-sa-dev"},{"subj":"T452","pred":"source","obj":"craft-sa-dev"},{"subj":"T453","pred":"source","obj":"craft-sa-dev"},{"subj":"T454","pred":"source","obj":"craft-sa-dev"},{"subj":"T455","pred":"source","obj":"craft-sa-dev"},{"subj":"T456","pred":"source","obj":"craft-sa-dev"},{"subj":"T457","pred":"source","obj":"craft-sa-dev"},{"subj":"T458","pred":"source","obj":"craft-sa-dev"},{"subj":"T459","pred":"source","obj":"craft-sa-dev"},{"subj":"T460","pred":"source","obj":"craft-sa-dev"},{"subj":"T461","pred":"source","obj":"craft-sa-dev"},{"subj":"T462","pred":"source","obj":"craft-sa-dev"},{"subj":"T463","pred":"source","obj":"craft-sa-dev"},{"subj":"T464","pred":"source","obj":"craft-sa-dev"},{"subj":"T465","pred":"source","obj":"craft-sa-dev"},{"subj":"T466","pred":"source","obj":"craft-sa-dev"},{"subj":"T467","pred":"source","obj":"craft-sa-dev"},{"subj":"T468","pred":"source","obj":"craft-sa-dev"},{"subj":"T469","pred":"source","obj":"craft-sa-dev"},{"subj":"T470","pred":"source","obj":"craft-sa-dev"},{"subj":"T471","pred":"source","obj":"craft-sa-dev"},{"subj":"T472","pred":"source","obj":"craft-sa-dev"},{"subj":"T473","pred":"source","obj":"craft-sa-dev"},{"subj":"T474","pred":"source","obj":"craft-sa-dev"},{"subj":"T475","pred":"source","obj":"craft-sa-dev"},{"subj":"T476","pred":"source","obj":"craft-sa-dev"},{"subj":"T477","pred":"source","obj":"craft-sa-dev"},{"subj":"T478","pred":"source","obj":"craft-sa-dev"},{"subj":"T479","pred":"source","obj":"craft-sa-dev"},{"subj":"T480","pred":"source","obj":"craft-sa-dev"},{"subj":"T481","pred":"source","obj":"craft-sa-dev"},{"subj":"T482","pred":"source","obj":"craft-sa-dev"},{"subj":"T483","pred":"source","obj":"craft-sa-dev"},{"subj":"T484","pred":"source","obj":"craft-sa-dev"},{"subj":"T485","pred":"source","obj":"craft-sa-dev"},{"subj":"T486","pred":"source","obj":"craft-sa-dev"},{"subj":"T487","pred":"source","obj":"craft-sa-dev"},{"subj":"T488","pred":"source","obj":"craft-sa-dev"},{"subj":"T489","pred":"source","obj":"craft-sa-dev"},{"subj":"T490","pred":"source","obj":"craft-sa-dev"},{"subj":"T491","pred":"source","obj":"craft-sa-dev"},{"subj":"T492","pred":"source","obj":"craft-sa-dev"},{"subj":"T493","pred":"source","obj":"craft-sa-dev"},{"subj":"T494","pred":"source","obj":"craft-sa-dev"},{"subj":"T495","pred":"source","obj":"craft-sa-dev"},{"subj":"T496","pred":"source","obj":"craft-sa-dev"},{"subj":"T497","pred":"source","obj":"craft-sa-dev"},{"subj":"T498","pred":"source","obj":"craft-sa-dev"},{"subj":"T499","pred":"source","obj":"craft-sa-dev"},{"subj":"T501","pred":"source","obj":"craft-sa-dev"},{"subj":"T502","pred":"source","obj":"craft-sa-dev"},{"subj":"T503","pred":"source","obj":"craft-sa-dev"},{"subj":"T504","pred":"source","obj":"craft-sa-dev"},{"subj":"T505","pred":"source","obj":"craft-sa-dev"},{"subj":"T506","pred":"source","obj":"craft-sa-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-ca-core-ex-dev","color":"#ec93db","default":true},{"id":"craft-ca-core-dev","color":"#93ece2"},{"id":"craft-sa-dev","color":"#ecc893"}]}]}}