Id |
Subject |
Object |
Predicate |
Lexical cue |
T14353 |
5110-5113 |
CC |
denotes |
and |
T14354 |
5114-5117 |
CD |
denotes |
two |
T14355 |
5118-5120 |
NN |
denotes |
P0 |
T14356 |
5121-5126 |
NNS |
denotes |
cases |
T14357 |
5126-5128 |
, |
denotes |
, |
T14358 |
5128-5131 |
CC |
denotes |
and |
T14359 |
5132-5138 |
VBP |
denotes |
report |
T14360 |
5139-5143 |
IN |
denotes |
that |
T14361 |
5173-5177 |
VBP |
denotes |
stop |
T14362 |
5144-5151 |
JJ |
denotes |
central |
T14363 |
5167-5172 |
NNS |
denotes |
axons |
T14364 |
5152-5166 |
JJ |
denotes |
proprioceptive |
T14365 |
5178-5180 |
IN |
denotes |
in |
T14366 |
5181-5184 |
DT |
denotes |
the |
T14367 |
5198-5205 |
NNS |
denotes |
laminae |
T14368 |
5185-5197 |
JJ |
denotes |
intermediate |
T14369 |
5205-5207 |
, |
denotes |
, |
T14370 |
5207-5212 |
RB |
denotes |
never |
T14371 |
5213-5221 |
VBG |
denotes |
entering |
T14372 |
5222-5225 |
DT |
denotes |
the |
T14373 |
5234-5238 |
NN |
denotes |
cord |
T14374 |
5226-5233 |
JJ |
denotes |
ventral |
T14375 |
5238-5239 |
. |
denotes |
. |
T14376 |
5239-5400 |
sentence |
denotes |
We have examined nine Bax/NT-3 double KO cases, and often incomplete DiI labeling gives the impression that there are no axons reaching the ventral spinal cord. |
T14377 |
5240-5242 |
PRP |
denotes |
We |
T14378 |
5248-5256 |
VBN |
denotes |
examined |
T14379 |
5243-5247 |
VBP |
denotes |
have |
T14380 |
5257-5261 |
CD |
denotes |
nine |
T14381 |
5281-5286 |
NNS |
denotes |
cases |
T14382 |
5262-5265 |
NN |
denotes |
Bax |
T14383 |
5278-5280 |
NN |
denotes |
KO |
T14384 |
5265-5266 |
HYPH |
denotes |
/ |
T14385 |
5266-5268 |
NN |
denotes |
NT |
T14386 |
5268-5269 |
HYPH |
denotes |
- |
T14387 |
5269-5270 |
CD |
denotes |
3 |
T14388 |
5271-5277 |
JJ |
denotes |
double |
T14389 |
5286-5288 |
, |
denotes |
, |
T14390 |
5288-5291 |
CC |
denotes |
and |
T14391 |
5292-5297 |
RB |
denotes |
often |
T14392 |
5322-5327 |
VBZ |
denotes |
gives |
T14393 |
5298-5308 |
JJ |
denotes |
incomplete |
T14394 |
5313-5321 |
NN |
denotes |
labeling |
T14395 |
5309-5312 |
NN |
denotes |
DiI |
T14396 |
5328-5331 |
DT |
denotes |
the |
T14397 |
5332-5342 |
NN |
denotes |
impression |
T14398 |
5343-5347 |
IN |
denotes |
that |
T14399 |
5354-5357 |
VBP |
denotes |
are |
T14400 |
5348-5353 |
EX |
denotes |
there |
T14401 |
5358-5360 |
DT |
denotes |
no |
T14402 |
5361-5366 |
NNS |
denotes |
axons |
T14403 |
5367-5375 |
VBG |
denotes |
reaching |
T14404 |
5376-5379 |
DT |
denotes |
the |
T14405 |
5395-5399 |
NN |
denotes |
cord |
T14406 |
5380-5387 |
JJ |
denotes |
ventral |
T14407 |
5388-5394 |
JJ |
denotes |
spinal |
T14408 |
5399-5400 |
. |
denotes |
. |
T14409 |
5400-5554 |
sentence |
denotes |
We have also seen cases similar to theirs (n = 4), but at higher magnification these axons did not have terminal boutons and were not completely labeled. |
T14410 |
5401-5403 |
PRP |
denotes |
We |
T14411 |
5414-5418 |
VBN |
denotes |
seen |
T14412 |
5404-5408 |
VBP |
denotes |
have |
T14413 |
5409-5413 |
RB |
denotes |
also |
T14414 |
5419-5424 |
NNS |
denotes |
cases |
T14415 |
5425-5432 |
JJ |
denotes |
similar |
T14416 |
5433-5435 |
IN |
denotes |
to |
T14417 |
5436-5442 |
PRP |
denotes |
theirs |
T14418 |
5443-5444 |
-LRB- |
denotes |
( |
T14419 |
5448-5449 |
CD |
denotes |
4 |
T14420 |
5444-5445 |
NN |
denotes |
n |
T14421 |
5446-5447 |
SYM |
denotes |
= |
T14422 |
5449-5450 |
-RRB- |
denotes |
) |
T14423 |
5450-5452 |
, |
denotes |
, |
T14424 |
5452-5455 |
CC |
denotes |
but |
T13384 |
11-21 |
RB |
denotes |
Relatively |
T13385 |
26-33 |
NNS |
denotes |
studies |
T13386 |
22-25 |
JJ |
denotes |
few |
T13387 |
39-49 |
VBN |
denotes |
implicated |
T13388 |
34-38 |
VBP |
denotes |
have |
T13389 |
50-52 |
NN |
denotes |
NT |
T13390 |
52-53 |
HYPH |
denotes |
- |
T13391 |
53-54 |
CD |
denotes |
3 |
T13392 |
55-57 |
IN |
denotes |
as |
T13393 |
58-59 |
DT |
denotes |
a |
T13394 |
76-81 |
NN |
denotes |
agent |
T13395 |
60-75 |
JJ |
denotes |
chemoattractant |
T13396 |
82-85 |
IN |
denotes |
for |
T13397 |
86-93 |
JJ |
denotes |
sensory |
T13398 |
104-109 |
NNS |
denotes |
axons |
T13399 |
94-97 |
CC |
denotes |
and |
T13400 |
98-103 |
NN |
denotes |
motor |
T13401 |
109-110 |
. |
denotes |
. |
T13402 |
110-343 |
sentence |
denotes |
Previously noted chemoattractant action of the embryonic mouse maxillary process on trigeminal ganglion neurons (Lumsden and Davies 1986) is now attributed to NT-3 and brain-derived neurotrophic factor (BDNF) (O'Connor et al. 1999). |
T13403 |
111-121 |
RB |
denotes |
Previously |
T13404 |
122-127 |
VBN |
denotes |
noted |
T13405 |
144-150 |
NN |
denotes |
action |
T13406 |
128-143 |
NN |
denotes |
chemoattractant |
T13407 |
256-266 |
VBN |
denotes |
attributed |
T13408 |
151-153 |
IN |
denotes |
of |
T13409 |
154-157 |
DT |
denotes |
the |
T13410 |
184-191 |
NN |
denotes |
process |
T13411 |
158-167 |
JJ |
denotes |
embryonic |
T13412 |
168-173 |
NN |
denotes |
mouse |
T13413 |
174-183 |
JJ |
denotes |
maxillary |
T13414 |
192-194 |
IN |
denotes |
on |
T13415 |
195-205 |
JJ |
denotes |
trigeminal |
T13416 |
215-222 |
NNS |
denotes |
neurons |
T13417 |
206-214 |
NN |
denotes |
ganglion |
T13418 |
223-224 |
-LRB- |
denotes |
( |
T13419 |
224-231 |
NNP |
denotes |
Lumsden |
T13420 |
232-235 |
CC |
denotes |
and |
T13421 |
236-242 |
NNP |
denotes |
Davies |
T13422 |
243-247 |
CD |
denotes |
1986 |
T13423 |
247-248 |
-RRB- |
denotes |
) |
T13424 |
249-251 |
VBZ |
denotes |
is |
T13425 |
252-255 |
RB |
denotes |
now |
T13426 |
267-269 |
IN |
denotes |
to |
T13427 |
270-272 |
NN |
denotes |
NT |
T13428 |
272-273 |
HYPH |
denotes |
- |
T13429 |
273-274 |
CD |
denotes |
3 |
T13430 |
275-278 |
CC |
denotes |
and |
T13431 |
279-284 |
NN |
denotes |
brain |
T13432 |
285-292 |
VBN |
denotes |
derived |
T13433 |
284-285 |
HYPH |
denotes |
- |
T13434 |
306-312 |
NN |
denotes |
factor |
T13435 |
293-305 |
JJ |
denotes |
neurotrophic |
T13436 |
313-314 |
-LRB- |
denotes |
( |
T13437 |
314-318 |
NN |
denotes |
BDNF |
T13438 |
318-319 |
-RRB- |
denotes |
) |
T13439 |
320-321 |
-LRB- |
denotes |
( |
T13440 |
321-329 |
NNP |
denotes |
O'Connor |
T13441 |
330-332 |
FW |
denotes |
et |
T13442 |
333-336 |
FW |
denotes |
al. |
T13443 |
337-341 |
CD |
denotes |
1999 |
T13444 |
341-342 |
-RRB- |
denotes |
) |
T13445 |
342-343 |
. |
denotes |
. |
T13446 |
343-546 |
sentence |
denotes |
Recently, Tucker et al. (2001) showed that developing sensory and motor axons in limb slice cultures preferentially grow towards neurotrophin-soaked beads instead of following their normal trajectories. |
T13447 |
344-352 |
RB |
denotes |
Recently |
T13448 |
375-381 |
VBD |
denotes |
showed |
T13449 |
352-354 |
, |
denotes |
, |
T13450 |
354-360 |
NNP |
denotes |
Tucker |
T13451 |
361-363 |
FW |
denotes |
et |
T13452 |
364-367 |
FW |
denotes |
al. |
T13453 |
368-369 |
-LRB- |
denotes |
( |
T13454 |
369-373 |
CD |
denotes |
2001 |
T13455 |
373-374 |
-RRB- |
denotes |
) |
T13456 |
382-386 |
IN |
denotes |
that |
T13457 |
460-464 |
VBP |
denotes |
grow |
T13458 |
387-397 |
JJ |
denotes |
developing |
T13459 |
416-421 |
NNS |
denotes |
axons |
T13460 |
398-405 |
JJ |
denotes |
sensory |
T13461 |
406-409 |
CC |
denotes |
and |
T13462 |
410-415 |
JJ |
denotes |
motor |
T13463 |
422-424 |
IN |
denotes |
in |
T13464 |
425-429 |
NN |
denotes |
limb |
T13465 |
430-435 |
NN |
denotes |
slice |
T13466 |
436-444 |
NNS |
denotes |
cultures |
T13467 |
445-459 |
RB |
denotes |
preferentially |
T13468 |
465-472 |
IN |
denotes |
towards |
T13469 |
473-485 |
NN |
denotes |
neurotrophin |
T13470 |
486-492 |
VBN |
denotes |
soaked |
T13471 |
485-486 |
HYPH |
denotes |
- |
T13472 |
493-498 |
NNS |
denotes |
beads |
T13473 |
499-506 |
RB |
denotes |
instead |
T13474 |
507-509 |
IN |
denotes |
of |
T13475 |
510-519 |
VBG |
denotes |
following |
T13476 |
520-525 |
PRP$ |
denotes |
their |
T13477 |
533-545 |
NNS |
denotes |
trajectories |
T13478 |
526-532 |
JJ |
denotes |
normal |
T13479 |
545-546 |
. |
denotes |
. |
T13480 |
546-686 |
sentence |
denotes |
Conversely, beads soaked with neurotrophin function-blocking antibodies led to reduction of sensory and motor axon growth towards the limb. |
T13481 |
547-557 |
RB |
denotes |
Conversely |
T13482 |
619-622 |
VBD |
denotes |
led |
T13483 |
557-559 |
, |
denotes |
, |
T13484 |
559-564 |
NNS |
denotes |
beads |
T13485 |
565-571 |
VBN |
denotes |
soaked |
T13486 |
572-576 |
IN |
denotes |
with |
T13487 |
577-589 |
NN |
denotes |
neurotrophin |
T13488 |
608-618 |
NNS |
denotes |
antibodies |
T13489 |
590-598 |
NN |
denotes |
function |
T13490 |
599-607 |
VBG |
denotes |
blocking |
T13491 |
598-599 |
HYPH |
denotes |
- |
T13492 |
623-625 |
IN |
denotes |
to |
T13493 |
626-635 |
NN |
denotes |
reduction |
T13494 |
636-638 |
IN |
denotes |
of |
T13495 |
639-646 |
JJ |
denotes |
sensory |
T13496 |
662-668 |
NN |
denotes |
growth |
T13497 |
647-650 |
CC |
denotes |
and |
T13498 |
651-656 |
JJ |
denotes |
motor |
T13499 |
657-661 |
NN |
denotes |
axon |
T13500 |
669-676 |
IN |
denotes |
towards |
T13501 |
677-680 |
DT |
denotes |
the |
T13502 |
681-685 |
NN |
denotes |
limb |
T13503 |
685-686 |
. |
denotes |
. |
T13504 |
686-963 |
sentence |
denotes |
In transgenic mice, which over-express NT-3 under the nestin promoter in the central nervous system, the course of the proprioceptive afferents are altered and directed towards the regions with high levels of ectopic NT-3 expression in the spinal cord (Ringstedt et al. 1997). |
T13505 |
687-689 |
IN |
denotes |
In |
T13506 |
835-842 |
VBN |
denotes |
altered |
T13507 |
690-700 |
JJ |
denotes |
transgenic |
T13508 |
701-705 |
NNS |
denotes |
mice |
T13509 |
705-707 |
, |
denotes |
, |
T13510 |
707-712 |
WDT |
denotes |
which |
T13511 |
713-725 |
VBP |
denotes |
over-express |
T13512 |
726-728 |
NN |
denotes |
NT |
T13513 |
728-729 |
HYPH |
denotes |
- |
T13514 |
729-730 |
CD |
denotes |
3 |
T13515 |
731-736 |
IN |
denotes |
under |
T13516 |
737-740 |
DT |
denotes |
the |
T13517 |
748-756 |
NN |
denotes |
promoter |
T13518 |
741-747 |
NN |
denotes |
nestin |
T13519 |
757-759 |
IN |
denotes |
in |
T13520 |
760-763 |
DT |
denotes |
the |
T13521 |
780-786 |
NN |
denotes |
system |
T13522 |
764-771 |
JJ |
denotes |
central |
T13523 |
772-779 |
JJ |
denotes |
nervous |
T13524 |
786-788 |
, |
denotes |
, |
T13525 |
788-791 |
DT |
denotes |
the |
T13526 |
792-798 |
NN |
denotes |
course |
T13527 |
799-801 |
IN |
denotes |
of |
T13528 |
802-805 |
DT |
denotes |
the |
T13529 |
821-830 |
NNS |
denotes |
afferents |
T13530 |
806-820 |
JJ |
denotes |
proprioceptive |
T13531 |
831-834 |
VBP |
denotes |
are |
T13532 |
843-846 |
CC |
denotes |
and |
T13533 |
847-855 |
VBN |
denotes |
directed |
T13534 |
856-863 |
IN |
denotes |
towards |
T13535 |
864-867 |
DT |
denotes |
the |
T13536 |
868-875 |
NNS |
denotes |
regions |
T13537 |
876-880 |
IN |
denotes |
with |
T13538 |
881-885 |
JJ |
denotes |
high |
T13539 |
886-892 |
NNS |
denotes |
levels |
T13540 |
893-895 |
IN |
denotes |
of |
T13541 |
896-903 |
JJ |
denotes |
ectopic |
T13542 |
909-919 |
NN |
denotes |
expression |
T13543 |
904-906 |
NN |
denotes |
NT |
T13544 |
906-907 |
HYPH |
denotes |
- |
T13545 |
907-908 |
CD |
denotes |
3 |
T13546 |
920-922 |
IN |
denotes |
in |
T13547 |
923-926 |
DT |
denotes |
the |
T13548 |
934-938 |
NN |
denotes |
cord |
T13549 |
927-933 |
JJ |
denotes |
spinal |
T13550 |
939-940 |
-LRB- |
denotes |
( |
T13551 |
940-949 |
NNP |
denotes |
Ringstedt |
T13552 |
950-952 |
FW |
denotes |
et |
T13553 |
953-956 |
FW |
denotes |
al. |
T13554 |
957-961 |
CD |
denotes |
1997 |
T13555 |
961-962 |
-RRB- |
denotes |
) |
T13556 |
962-963 |
. |
denotes |
. |
T13557 |
963-1118 |
sentence |
denotes |
Ringstedt et al. considered the possibility that NT-3 may play a chemoattractant role during the innervation of ventral horns by proprioceptive afferents. |
T13558 |
964-973 |
NNP |
denotes |
Ringstedt |
T13559 |
981-991 |
VBD |
denotes |
considered |
T13560 |
974-976 |
FW |
denotes |
et |
T13561 |
977-980 |
FW |
denotes |
al. |
T13562 |
992-995 |
DT |
denotes |
the |
T13563 |
996-1007 |
NN |
denotes |
possibility |
T13564 |
1008-1012 |
IN |
denotes |
that |
T13565 |
1022-1026 |
VB |
denotes |
play |
T13566 |
1013-1015 |
NN |
denotes |
NT |
T13567 |
1015-1016 |
HYPH |
denotes |
- |
T13568 |
1016-1017 |
CD |
denotes |
3 |
T13569 |
1018-1021 |
MD |
denotes |
may |
T13570 |
1027-1028 |
DT |
denotes |
a |
T13571 |
1045-1049 |
NN |
denotes |
role |
T13572 |
1029-1044 |
NN |
denotes |
chemoattractant |
T13573 |
1050-1056 |
IN |
denotes |
during |
T13574 |
1057-1060 |
DT |
denotes |
the |
T13575 |
1061-1072 |
NN |
denotes |
innervation |
T13576 |
1073-1075 |
IN |
denotes |
of |
T13577 |
1076-1083 |
JJ |
denotes |
ventral |
T13578 |
1084-1089 |
NNS |
denotes |
horns |
T13579 |
1090-1092 |
IN |
denotes |
by |
T13580 |
1093-1107 |
JJ |
denotes |
proprioceptive |
T13581 |
1108-1117 |
NNS |
denotes |
afferents |
T13582 |
1117-1118 |
. |
denotes |
. |
T13583 |
1118-1344 |
sentence |
denotes |
However, earlier findings of normal proprioceptive afferent trajectories in chicken embryos despite injection of function-blocking NT-3 antibody into the spinal cord (Oakley et al. 1995) led them to discount this possibility. |
T13584 |
1119-1126 |
RB |
denotes |
However |
T13585 |
1306-1309 |
VBD |
denotes |
led |
T13586 |
1126-1128 |
, |
denotes |
, |
T13587 |
1128-1135 |
JJR |
denotes |
earlier |
T13588 |
1136-1144 |
NNS |
denotes |
findings |
T13589 |
1145-1147 |
IN |
denotes |
of |
T13590 |
1148-1154 |
JJ |
denotes |
normal |
T13591 |
1179-1191 |
NNS |
denotes |
trajectories |
T13592 |
1155-1169 |
JJ |
denotes |
proprioceptive |
T13593 |
1170-1178 |
JJ |
denotes |
afferent |
T13594 |
1192-1194 |
IN |
denotes |
in |
T13595 |
1195-1202 |
NN |
denotes |
chicken |
T13596 |
1203-1210 |
NNS |
denotes |
embryos |
T13597 |
1211-1218 |
IN |
denotes |
despite |
T13598 |
1219-1228 |
NN |
denotes |
injection |
T13599 |
1229-1231 |
IN |
denotes |
of |
T13600 |
1232-1240 |
NN |
denotes |
function |
T13601 |
1241-1249 |
VBG |
denotes |
blocking |
T13602 |
1240-1241 |
HYPH |
denotes |
- |
T13603 |
1255-1263 |
NN |
denotes |
antibody |
T13604 |
1250-1252 |
NN |
denotes |
NT |
T13605 |
1252-1253 |
HYPH |
denotes |
- |
T13606 |
1253-1254 |
CD |
denotes |
3 |
T13607 |
1264-1268 |
IN |
denotes |
into |
T13608 |
1269-1272 |
DT |
denotes |
the |
T13609 |
1280-1284 |
NN |
denotes |
cord |
T13610 |
1273-1279 |
JJ |
denotes |
spinal |
T13611 |
1285-1286 |
-LRB- |
denotes |
( |
T13612 |
1286-1292 |
NNP |
denotes |
Oakley |
T13613 |
1293-1295 |
FW |
denotes |
et |
T13614 |
1296-1299 |
FW |
denotes |
al. |
T13615 |
1300-1304 |
CD |
denotes |
1995 |
T13616 |
1304-1305 |
-RRB- |
denotes |
) |
T13617 |
1310-1314 |
PRP |
denotes |
them |
T13618 |
1315-1317 |
TO |
denotes |
to |
T13619 |
1318-1326 |
VB |
denotes |
discount |
T13620 |
1327-1331 |
DT |
denotes |
this |
T13621 |
1332-1343 |
NN |
denotes |
possibility |
T13622 |
1343-1344 |
. |
denotes |
. |
T13623 |
1344-1553 |
sentence |
denotes |
In that study, though, assays on the effectiveness of antibody perturbation on NT-3-dependent cell survival showed that effectiveness was significant (approximately 90%) but not complete (Oakley et al. 1995). |
T13624 |
1345-1347 |
IN |
denotes |
In |
T13625 |
1453-1459 |
VBD |
denotes |
showed |
T13626 |
1348-1352 |
DT |
denotes |
that |
T13627 |
1353-1358 |
NN |
denotes |
study |
T13628 |
1358-1360 |
, |
denotes |
, |
T13629 |
1360-1366 |
RB |
denotes |
though |
T13630 |
1366-1368 |
, |
denotes |
, |
T13631 |
1368-1374 |
NNS |
denotes |
assays |
T13632 |
1375-1377 |
IN |
denotes |
on |
T13633 |
1378-1381 |
DT |
denotes |
the |
T13634 |
1382-1395 |
NN |
denotes |
effectiveness |
T13635 |
1396-1398 |
IN |
denotes |
of |
T13636 |
1399-1407 |
NN |
denotes |
antibody |
T13637 |
1408-1420 |
NN |
denotes |
perturbation |
T13638 |
1421-1423 |
IN |
denotes |
on |
T13639 |
1424-1426 |
NN |
denotes |
NT |
T13640 |
1429-1438 |
JJ |
denotes |
dependent |
T13641 |
1426-1427 |
HYPH |
denotes |
- |
T13642 |
1427-1428 |
CD |
denotes |
3 |
T13643 |
1428-1429 |
HYPH |
denotes |
- |
T13644 |
1444-1452 |
NN |
denotes |
survival |
T13645 |
1439-1443 |
NN |
denotes |
cell |
T13646 |
1460-1464 |
IN |
denotes |
that |
T13647 |
1479-1482 |
VBD |
denotes |
was |
T13648 |
1465-1478 |
NN |
denotes |
effectiveness |
T13649 |
1483-1494 |
JJ |
denotes |
significant |
T13650 |
1495-1496 |
-LRB- |
denotes |
( |
T13651 |
1512-1513 |
NN |
denotes |
% |
T13652 |
1496-1509 |
RB |
denotes |
approximately |
T13653 |
1510-1512 |
CD |
denotes |
90 |
T13654 |
1513-1514 |
-RRB- |
denotes |
) |
T13655 |
1515-1518 |
CC |
denotes |
but |
T13656 |
1519-1522 |
RB |
denotes |
not |
T13657 |
1523-1531 |
JJ |
denotes |
complete |
T13658 |
1532-1533 |
-LRB- |
denotes |
( |
T13659 |
1533-1539 |
NNP |
denotes |
Oakley |
T13660 |
1540-1542 |
FW |
denotes |
et |
T13661 |
1543-1546 |
FW |
denotes |
al. |
T13662 |
1547-1551 |
CD |
denotes |
1995 |
T13663 |
1551-1552 |
-RRB- |
denotes |
) |
T13664 |
1552-1553 |
. |
denotes |
. |
T13665 |
1553-1721 |
sentence |
denotes |
Ringstedt et al. (1997) argue that while central sensory axons may still navigate properly in the absence of NT-3, ectopic expression of NT-3 disrupts their targeting. |
T13666 |
1554-1563 |
NNP |
denotes |
Ringstedt |
T13667 |
1578-1583 |
VBP |
denotes |
argue |
T13668 |
1564-1566 |
FW |
denotes |
et |
T13669 |
1567-1570 |
FW |
denotes |
al. |
T13670 |
1571-1572 |
-LRB- |
denotes |
( |
T13671 |
1572-1576 |
CD |
denotes |
1997 |
T13672 |
1576-1577 |
-RRB- |
denotes |
) |
T13673 |
1584-1588 |
IN |
denotes |
that |
T13674 |
1696-1704 |
VBZ |
denotes |
disrupts |
T13675 |
1589-1594 |
IN |
denotes |
while |
T13676 |
1627-1635 |
VB |
denotes |
navigate |
T13677 |
1595-1602 |
JJ |
denotes |
central |
T13678 |
1611-1616 |
NNS |
denotes |
axons |
T13679 |
1603-1610 |
JJ |
denotes |
sensory |
T13680 |
1617-1620 |
MD |
denotes |
may |
T13681 |
1621-1626 |
RB |
denotes |
still |
T13682 |
1636-1644 |
RB |
denotes |
properly |
T13683 |
1645-1647 |
IN |
denotes |
in |
T13684 |
1648-1651 |
DT |
denotes |
the |
T13685 |
1652-1659 |
NN |
denotes |
absence |
T13686 |
1660-1662 |
IN |
denotes |
of |
T13687 |
1663-1665 |
NN |
denotes |
NT |
T13688 |
1665-1666 |
HYPH |
denotes |
- |
T13689 |
1666-1667 |
CD |
denotes |
3 |
T13690 |
1667-1669 |
, |
denotes |
, |
T13691 |
1669-1676 |
JJ |
denotes |
ectopic |
T13692 |
1677-1687 |
NN |
denotes |
expression |
T13693 |
1688-1690 |
IN |
denotes |
of |
T13694 |
1691-1693 |
NN |
denotes |
NT |
T13695 |
1693-1694 |
HYPH |
denotes |
- |
T13696 |
1694-1695 |
CD |
denotes |
3 |
T13697 |
1705-1710 |
PRP$ |
denotes |
their |
T13698 |
1711-1720 |
NN |
denotes |
targeting |
T13699 |
1720-1721 |
. |
denotes |
. |
T13700 |
1721-1887 |
sentence |
denotes |
Recently, another member of the neurotrophin family, BDNF, has been suggested to act as a chemoattractant for sensory axons innervating ear (Tessarollo et al. 2004). |
T13701 |
1722-1730 |
RB |
denotes |
Recently |
T13702 |
1790-1799 |
VBN |
denotes |
suggested |
T13703 |
1730-1732 |
, |
denotes |
, |
T13704 |
1732-1739 |
DT |
denotes |
another |
T13705 |
1740-1746 |
NN |
denotes |
member |
T13706 |
1747-1749 |
IN |
denotes |
of |
T13707 |
1750-1753 |
DT |
denotes |
the |
T13708 |
1767-1773 |
NN |
denotes |
family |
T13709 |
1754-1766 |
NN |
denotes |
neurotrophin |
T13710 |
1773-1775 |
, |
denotes |
, |
T13711 |
1775-1779 |
NN |
denotes |
BDNF |
T13712 |
1779-1781 |
, |
denotes |
, |
T13713 |
1781-1784 |
VBZ |
denotes |
has |
T13714 |
1785-1789 |
VBN |
denotes |
been |
T13715 |
1800-1802 |
TO |
denotes |
to |
T13716 |
1803-1806 |
VB |
denotes |
act |
T13717 |
1807-1809 |
IN |
denotes |
as |
T13718 |
1810-1811 |
DT |
denotes |
a |
T13719 |
1812-1827 |
NN |
denotes |
chemoattractant |
T13720 |
1828-1831 |
IN |
denotes |
for |
T13721 |
1832-1839 |
JJ |
denotes |
sensory |
T13722 |
1840-1845 |
NNS |
denotes |
axons |
T13723 |
1858-1861 |
NN |
denotes |
ear |
T13724 |
1846-1857 |
VBG |
denotes |
innervating |
T13725 |
1862-1863 |
-LRB- |
denotes |
( |
T13726 |
1863-1873 |
NNP |
denotes |
Tessarollo |
T13727 |
1874-1876 |
FW |
denotes |
et |
T13728 |
1877-1880 |
FW |
denotes |
al. |
T13729 |
1881-1885 |
CD |
denotes |
2004 |
T13730 |
1885-1886 |
-RRB- |
denotes |
) |
T13731 |
1886-1887 |
. |
denotes |
. |
T13732 |
1887-2118 |
sentence |
denotes |
In a gene replacement strategy in which BDNF expression was driven by the NT-3 promoter, vestibular axons rerouted towards ectopic sources of BDNF in the cochlea that normally expressed NT-3 and were not innervated by these axons. |
T13733 |
1888-1890 |
IN |
denotes |
In |
T13734 |
1994-2002 |
VBP |
denotes |
rerouted |
T13735 |
1891-1892 |
DT |
denotes |
a |
T13736 |
1910-1918 |
NN |
denotes |
strategy |
T13737 |
1893-1897 |
NN |
denotes |
gene |
T13738 |
1898-1909 |
NN |
denotes |
replacement |
T13739 |
1919-1921 |
IN |
denotes |
in |
T13740 |
1948-1954 |
VBN |
denotes |
driven |
T13741 |
1922-1927 |
WDT |
denotes |
which |
T13742 |
1928-1932 |
NN |
denotes |
BDNF |
T13743 |
1933-1943 |
NN |
denotes |
expression |
T13744 |
1944-1947 |
VBD |
denotes |
was |
T13745 |
1955-1957 |
IN |
denotes |
by |
T13746 |
1958-1961 |
DT |
denotes |
the |
T13747 |
1967-1975 |
NN |
denotes |
promoter |
T13748 |
1962-1964 |
NN |
denotes |
NT |
T13749 |
1964-1965 |
HYPH |
denotes |
- |
T13750 |
1965-1966 |
CD |
denotes |
3 |
T13751 |
1975-1977 |
, |
denotes |
, |
T13752 |
1977-1987 |
JJ |
denotes |
vestibular |
T13753 |
1988-1993 |
NNS |
denotes |
axons |
T13754 |
2003-2010 |
IN |
denotes |
towards |
T13755 |
2011-2018 |
JJ |
denotes |
ectopic |
T13756 |
2019-2026 |
NNS |
denotes |
sources |
T13757 |
2027-2029 |
IN |
denotes |
of |
T13758 |
2030-2034 |
NN |
denotes |
BDNF |
T13759 |
2035-2037 |
IN |
denotes |
in |
T13760 |
2038-2041 |
DT |
denotes |
the |
T13761 |
2042-2049 |
NN |
denotes |
cochlea |
T13762 |
2050-2054 |
WDT |
denotes |
that |
T13763 |
2064-2073 |
VBD |
denotes |
expressed |
T13764 |
2055-2063 |
RB |
denotes |
normally |
T13765 |
2074-2076 |
NN |
denotes |
NT |
T13766 |
2076-2077 |
HYPH |
denotes |
- |
T13767 |
2077-2078 |
CD |
denotes |
3 |
T13768 |
2079-2082 |
CC |
denotes |
and |
T13769 |
2083-2087 |
VBD |
denotes |
were |
T13770 |
2092-2102 |
VBN |
denotes |
innervated |
T13771 |
2088-2091 |
RB |
denotes |
not |
T13772 |
2103-2105 |
IN |
denotes |
by |
T13773 |
2106-2111 |
DT |
denotes |
these |
T13774 |
2112-2117 |
NNS |
denotes |
axons |
T13775 |
2117-2118 |
. |
denotes |
. |
T13776 |
2118-2553 |
sentence |
denotes |
Ectopic NT-3 supplied using osmotic pumps and adenovirus-mediated expression induce sensory axon growth during regeneration (Zhang et al. 1998, Bradbury et al. 1999, Oudega et al. 1999, Ramer et al. 2002), and induce axonal plasticity of corticospinal axons in injured adult spinal cord (Zhou et al. 2003), where the sprouting axons from the intact site cross the midline towards the NT-3 source on the lesion side of the spinal cord. |
T13777 |
2119-2126 |
JJ |
denotes |
Ectopic |
T13778 |
2127-2129 |
NN |
denotes |
NT |
T13779 |
2196-2202 |
VBP |
denotes |
induce |
T13780 |
2129-2130 |
HYPH |
denotes |
- |
T13781 |
2130-2131 |
CD |
denotes |
3 |
T13782 |
2132-2140 |
VBN |
denotes |
supplied |
T13783 |
2141-2146 |
VBG |
denotes |
using |
T13784 |
2147-2154 |
JJ |
denotes |
osmotic |
T13785 |
2155-2160 |
NNS |
denotes |
pumps |
T13786 |
2161-2164 |
CC |
denotes |
and |
T13787 |
2165-2175 |
NN |
denotes |
adenovirus |
T13788 |
2176-2184 |
VBN |
denotes |
mediated |
T13789 |
2175-2176 |
HYPH |
denotes |
- |
T13790 |
2185-2195 |
NN |
denotes |
expression |
T13791 |
2203-2210 |
JJ |
denotes |
sensory |
T13792 |
2216-2222 |
NN |
denotes |
growth |
T13793 |
2211-2215 |
NN |
denotes |
axon |
T13794 |
2223-2229 |
IN |
denotes |
during |
T13795 |
2230-2242 |
NN |
denotes |
regeneration |
T13796 |
2243-2244 |
-LRB- |
denotes |
( |
T13797 |
2244-2249 |
NNP |
denotes |
Zhang |
T13798 |
2250-2252 |
FW |
denotes |
et |
T13799 |
2253-2256 |
FW |
denotes |
al. |
T13800 |
2257-2261 |
CD |
denotes |
1998 |
T13801 |
2261-2263 |
, |
denotes |
, |
T13802 |
2263-2271 |
NNP |
denotes |
Bradbury |
T13803 |
2272-2274 |
FW |
denotes |
et |
T13804 |
2275-2278 |
FW |
denotes |
al. |
T13805 |
2279-2283 |
CD |
denotes |
1999 |
T13806 |
2283-2285 |
, |
denotes |
, |
T13807 |
2285-2291 |
NNP |
denotes |
Oudega |
T13808 |
2292-2294 |
FW |
denotes |
et |
T13809 |
2295-2298 |
FW |
denotes |
al. |
T13810 |
2299-2303 |
CD |
denotes |
1999 |
T13811 |
2303-2305 |
, |
denotes |
, |
T13812 |
2305-2310 |
NNP |
denotes |
Ramer |
T13813 |
2311-2313 |
FW |
denotes |
et |
T13814 |
2314-2317 |
FW |
denotes |
al. |
T13815 |
2318-2322 |
CD |
denotes |
2002 |
T13816 |
2322-2323 |
-RRB- |
denotes |
) |
T13817 |
2323-2325 |
, |
denotes |
, |
T13818 |
2325-2328 |
CC |
denotes |
and |
T13819 |
2329-2335 |
VBP |
denotes |
induce |
T13820 |
2336-2342 |
JJ |
denotes |
axonal |
T13821 |
2343-2353 |
NN |
denotes |
plasticity |
T13822 |
2354-2356 |
IN |
denotes |
of |
T13823 |
2357-2370 |
JJ |
denotes |
corticospinal |
T13824 |
2371-2376 |
NNS |
denotes |
axons |
T13825 |
2377-2379 |
IN |
denotes |
in |
T13826 |
2380-2387 |
VBN |
denotes |
injured |
T13827 |
2401-2405 |
NN |
denotes |
cord |
T13828 |
2388-2393 |
JJ |
denotes |
adult |
T13829 |
2394-2400 |
JJ |
denotes |
spinal |
T13830 |
2406-2407 |
-LRB- |
denotes |
( |
T13831 |
2407-2411 |
NNP |
denotes |
Zhou |
T13832 |
2412-2414 |
FW |
denotes |
et |
T13833 |
2415-2418 |
FW |
denotes |
al. |
T13834 |
2419-2423 |
CD |
denotes |
2003 |
T13835 |
2423-2424 |
-RRB- |
denotes |
) |
T13836 |
2424-2426 |
, |
denotes |
, |
T13837 |
2426-2431 |
WRB |
denotes |
where |
T13838 |
2473-2478 |
VBP |
denotes |
cross |
T13839 |
2432-2435 |
DT |
denotes |
the |
T13840 |
2446-2451 |
NNS |
denotes |
axons |
T13841 |
2436-2445 |
VBG |
denotes |
sprouting |
T13842 |
2452-2456 |
IN |
denotes |
from |
T13843 |
2457-2460 |
DT |
denotes |
the |
T13844 |
2468-2472 |
NN |
denotes |
site |
T13845 |
2461-2467 |
JJ |
denotes |
intact |
T13846 |
2479-2482 |
DT |
denotes |
the |
T13847 |
2483-2490 |
NN |
denotes |
midline |
T13848 |
2491-2498 |
IN |
denotes |
towards |
T13849 |
2499-2502 |
DT |
denotes |
the |
T13850 |
2508-2514 |
NN |
denotes |
source |
T13851 |
2503-2505 |
NN |
denotes |
NT |
T13852 |
2505-2506 |
HYPH |
denotes |
- |
T13853 |
2506-2507 |
CD |
denotes |
3 |
T13854 |
2515-2517 |
IN |
denotes |
on |
T13855 |
2518-2521 |
DT |
denotes |
the |
T13856 |
2529-2533 |
NN |
denotes |
side |
T13857 |
2522-2528 |
NN |
denotes |
lesion |
T13858 |
2534-2536 |
IN |
denotes |
of |
T13859 |
2537-2540 |
DT |
denotes |
the |
T13860 |
2548-2552 |
NN |
denotes |
cord |
T13861 |
2541-2547 |
JJ |
denotes |
spinal |
T13862 |
2552-2553 |
. |
denotes |
. |
T13863 |
2553-2703 |
sentence |
denotes |
Our present results are in agreement with these observations, and provide further evidence that NT-3 acts as a chemoattractant for sensory afferents. |
T13864 |
2554-2557 |
PRP$ |
denotes |
Our |
T13865 |
2566-2573 |
NNS |
denotes |
results |
T13866 |
2558-2565 |
JJ |
denotes |
present |
T13867 |
2574-2577 |
VBP |
denotes |
are |
T13868 |
2578-2580 |
IN |
denotes |
in |
T13869 |
2581-2590 |
NN |
denotes |
agreement |
T13870 |
2591-2595 |
IN |
denotes |
with |
T13871 |
2596-2601 |
DT |
denotes |
these |
T13872 |
2602-2614 |
NNS |
denotes |
observations |
T13873 |
2614-2616 |
, |
denotes |
, |
T13874 |
2616-2619 |
CC |
denotes |
and |
T13875 |
2620-2627 |
VBP |
denotes |
provide |
T13876 |
2628-2635 |
JJ |
denotes |
further |
T13877 |
2636-2644 |
NN |
denotes |
evidence |
T13878 |
2645-2649 |
IN |
denotes |
that |
T13879 |
2655-2659 |
VBZ |
denotes |
acts |
T13880 |
2650-2652 |
NN |
denotes |
NT |
T13881 |
2652-2653 |
HYPH |
denotes |
- |
T13882 |
2653-2654 |
CD |
denotes |
3 |
T13883 |
2660-2662 |
IN |
denotes |
as |
T13884 |
2663-2664 |
DT |
denotes |
a |
T13885 |
2665-2680 |
NN |
denotes |
chemoattractant |
T13886 |
2681-2684 |
IN |
denotes |
for |
T13887 |
2685-2692 |
JJ |
denotes |
sensory |
T13888 |
2693-2702 |
NNS |
denotes |
afferents |
T13889 |
2702-2703 |
. |
denotes |
. |
T13890 |
2703-2853 |
sentence |
denotes |
Previously, normal motor neuron innervation was rescued in NT-3 KO animals by over-expressing NT-3 selectively in their muscles (Wright et al. 1997). |
T13891 |
2704-2714 |
RB |
denotes |
Previously |
T13892 |
2752-2759 |
VBN |
denotes |
rescued |
T13893 |
2714-2716 |
, |
denotes |
, |
T13894 |
2716-2722 |
JJ |
denotes |
normal |
T13895 |
2736-2747 |
NN |
denotes |
innervation |
T13896 |
2723-2728 |
NN |
denotes |
motor |
T13897 |
2729-2735 |
NN |
denotes |
neuron |
T13898 |
2748-2751 |
VBD |
denotes |
was |
T13899 |
2760-2762 |
IN |
denotes |
in |
T13900 |
2763-2765 |
NN |
denotes |
NT |
T13901 |
2768-2770 |
NN |
denotes |
KO |
T13902 |
2765-2766 |
HYPH |
denotes |
- |
T13903 |
2766-2767 |
CD |
denotes |
3 |
T13904 |
2771-2778 |
NNS |
denotes |
animals |
T13905 |
2779-2781 |
IN |
denotes |
by |
T13906 |
2782-2797 |
VBG |
denotes |
over-expressing |
T13907 |
2798-2800 |
NN |
denotes |
NT |
T13908 |
2800-2801 |
HYPH |
denotes |
- |
T13909 |
2801-2802 |
CD |
denotes |
3 |
T13910 |
2803-2814 |
RB |
denotes |
selectively |
T13911 |
2815-2817 |
IN |
denotes |
in |
T13912 |
2818-2823 |
PRP$ |
denotes |
their |
T13913 |
2824-2831 |
NNS |
denotes |
muscles |
T13914 |
2832-2833 |
-LRB- |
denotes |
( |
T13915 |
2833-2839 |
NNP |
denotes |
Wright |
T13916 |
2840-2842 |
FW |
denotes |
et |
T13917 |
2843-2846 |
FW |
denotes |
al. |
T13918 |
2847-2851 |
CD |
denotes |
1997 |
T13919 |
2851-2852 |
-RRB- |
denotes |
) |
T13920 |
2852-2853 |
. |
denotes |
. |
T13921 |
2853-3010 |
sentence |
denotes |
It appears that peripheral NT-3 alone is sufficient for rescuing proprioceptive neurons in NT-3 KO animals and proper axonal pathfinding in the spinal cord. |
T13922 |
2854-2856 |
PRP |
denotes |
It |
T13923 |
2857-2864 |
VBZ |
denotes |
appears |
T13924 |
2865-2869 |
IN |
denotes |
that |
T13925 |
2892-2894 |
VBZ |
denotes |
is |
T13926 |
2870-2880 |
JJ |
denotes |
peripheral |
T13927 |
2881-2883 |
NN |
denotes |
NT |
T13928 |
2883-2884 |
HYPH |
denotes |
- |
T13929 |
2884-2885 |
CD |
denotes |
3 |
T13930 |
2886-2891 |
RB |
denotes |
alone |
T13931 |
2895-2905 |
JJ |
denotes |
sufficient |
T13932 |
2906-2909 |
IN |
denotes |
for |
T13933 |
2910-2918 |
VBG |
denotes |
rescuing |
T13934 |
2919-2933 |
JJ |
denotes |
proprioceptive |
T13935 |
2934-2941 |
NNS |
denotes |
neurons |
T13936 |
2942-2944 |
IN |
denotes |
in |
T13937 |
2945-2947 |
NN |
denotes |
NT |
T13938 |
2950-2952 |
NN |
denotes |
KO |
T13939 |
2947-2948 |
HYPH |
denotes |
- |
T13940 |
2948-2949 |
CD |
denotes |
3 |
T13941 |
2953-2960 |
NNS |
denotes |
animals |
T13942 |
2961-2964 |
CC |
denotes |
and |
T13943 |
2965-2971 |
JJ |
denotes |
proper |
T13944 |
2979-2990 |
NN |
denotes |
pathfinding |
T13945 |
2972-2978 |
JJ |
denotes |
axonal |
T13946 |
2991-2993 |
IN |
denotes |
in |
T13947 |
2994-2997 |
DT |
denotes |
the |
T13948 |
3005-3009 |
NN |
denotes |
cord |
T13949 |
2998-3004 |
JJ |
denotes |
spinal |
T13950 |
3009-3010 |
. |
denotes |
. |
T13951 |
3010-3104 |
sentence |
denotes |
However, it is unclear whether NT-3 is absent from the ventral spinal cords of these animals. |
T13952 |
3011-3018 |
RB |
denotes |
However |
T13953 |
3023-3025 |
VBZ |
denotes |
is |
T13954 |
3018-3020 |
, |
denotes |
, |
T13955 |
3020-3022 |
PRP |
denotes |
it |
T13956 |
3026-3033 |
JJ |
denotes |
unclear |
T13957 |
3034-3041 |
IN |
denotes |
whether |
T13958 |
3047-3049 |
VBZ |
denotes |
is |
T13959 |
3042-3044 |
NN |
denotes |
NT |
T13960 |
3044-3045 |
HYPH |
denotes |
- |
T13961 |
3045-3046 |
CD |
denotes |
3 |
T13962 |
3050-3056 |
JJ |
denotes |
absent |
T13963 |
3057-3061 |
IN |
denotes |
from |
T13964 |
3062-3065 |
DT |
denotes |
the |
T13965 |
3081-3086 |
NNS |
denotes |
cords |
T13966 |
3066-3073 |
JJ |
denotes |
ventral |
T13967 |
3074-3080 |
JJ |
denotes |
spinal |
T13968 |
3087-3089 |
IN |
denotes |
of |
T13969 |
3090-3095 |
DT |
denotes |
these |
T13970 |
3096-3103 |
NNS |
denotes |
animals |
T13971 |
3103-3104 |
. |
denotes |
. |
T13972 |
3104-3239 |
sentence |
denotes |
The possibility has been raised that motor neurons may retrogradely transport NT-3 in muscle to the spinal cord (Chen and Frank 1999). |
T13973 |
3105-3108 |
DT |
denotes |
The |
T13974 |
3109-3120 |
NN |
denotes |
possibility |
T13975 |
3130-3136 |
VBN |
denotes |
raised |
T13976 |
3121-3124 |
VBZ |
denotes |
has |
T13977 |
3125-3129 |
VBN |
denotes |
been |
T13978 |
3137-3141 |
IN |
denotes |
that |
T13979 |
3173-3182 |
VB |
denotes |
transport |
T13980 |
3142-3147 |
NN |
denotes |
motor |
T13981 |
3148-3155 |
NNS |
denotes |
neurons |
T13982 |
3156-3159 |
MD |
denotes |
may |
T13983 |
3160-3172 |
RB |
denotes |
retrogradely |
T13984 |
3183-3185 |
NN |
denotes |
NT |
T13985 |
3185-3186 |
HYPH |
denotes |
- |
T13986 |
3186-3187 |
CD |
denotes |
3 |
T13987 |
3188-3190 |
IN |
denotes |
in |
T13988 |
3191-3197 |
NN |
denotes |
muscle |
T13989 |
3198-3200 |
IN |
denotes |
to |
T13990 |
3201-3204 |
DT |
denotes |
the |
T13991 |
3212-3216 |
NN |
denotes |
cord |
T13992 |
3205-3211 |
JJ |
denotes |
spinal |
T13993 |
3217-3218 |
-LRB- |
denotes |
( |
T13994 |
3218-3222 |
NNP |
denotes |
Chen |
T13996 |
3227-3232 |
NNP |
denotes |
Frank |
T13997 |
3233-3237 |
CD |
denotes |
1999 |
T13998 |
3237-3238 |
-RRB- |
denotes |
) |
T13999 |
3238-3239 |
. |
denotes |
. |
T14000 |
3239-3344 |
sentence |
denotes |
Assays to determine whether any NT-3 is present in the ventral horns of these mice would be informative. |
T14001 |
3240-3246 |
NNS |
denotes |
Assays |
T14002 |
3329-3331 |
VB |
denotes |
be |
T14003 |
3247-3249 |
TO |
denotes |
to |
T14004 |
3250-3259 |
VB |
denotes |
determine |
T14005 |
3260-3267 |
IN |
denotes |
whether |
T14006 |
3277-3279 |
VBZ |
denotes |
is |
T14007 |
3268-3271 |
DT |
denotes |
any |
T14008 |
3272-3274 |
NN |
denotes |
NT |
T14009 |
3274-3275 |
HYPH |
denotes |
- |
T14010 |
3275-3276 |
CD |
denotes |
3 |
T14011 |
3280-3287 |
JJ |
denotes |
present |
T14012 |
3288-3290 |
IN |
denotes |
in |
T14013 |
3291-3294 |
DT |
denotes |
the |
T14014 |
3303-3308 |
NNS |
denotes |
horns |
T14015 |
3295-3302 |
JJ |
denotes |
ventral |
T14016 |
3309-3311 |
IN |
denotes |
of |
T14017 |
3312-3317 |
DT |
denotes |
these |
T14018 |
3318-3322 |
NNS |
denotes |
mice |
T14019 |
3323-3328 |
MD |
denotes |
would |
T14020 |
3332-3343 |
JJ |
denotes |
informative |
T14021 |
3343-3344 |
. |
denotes |
. |
T14022 |
3344-3440 |
sentence |
denotes |
Recently, Patel et al. (2003) reported their observations on Bax/NT-3 double KO mice they bred. |
T14023 |
3345-3353 |
RB |
denotes |
Recently |
T14024 |
3375-3383 |
VBD |
denotes |
reported |
T14025 |
3353-3355 |
, |
denotes |
, |
T14026 |
3355-3360 |
NNP |
denotes |
Patel |
T14027 |
3361-3363 |
FW |
denotes |
et |
T14028 |
3364-3367 |
FW |
denotes |
al. |
T14029 |
3368-3369 |
-LRB- |
denotes |
( |
T14030 |
3369-3373 |
CD |
denotes |
2003 |
T14031 |
3373-3374 |
-RRB- |
denotes |
) |
T14032 |
3384-3389 |
PRP$ |
denotes |
their |
T14033 |
3390-3402 |
NNS |
denotes |
observations |
T14034 |
3403-3405 |
IN |
denotes |
on |
T14035 |
3406-3409 |
NN |
denotes |
Bax |
T14036 |
3422-3424 |
NN |
denotes |
KO |
T14037 |
3409-3410 |
HYPH |
denotes |
/ |
T14038 |
3410-3412 |
NN |
denotes |
NT |
T14039 |
3412-3413 |
HYPH |
denotes |
- |
T14040 |
3413-3414 |
CD |
denotes |
3 |
T14041 |
3415-3421 |
JJ |
denotes |
double |
T14042 |
3425-3429 |
NNS |
denotes |
mice |
T14043 |
3430-3434 |
PRP |
denotes |
they |
T14044 |
3435-3439 |
VBD |
denotes |
bred |
T14045 |
3439-3440 |
. |
denotes |
. |
T14046 |
3440-3493 |
sentence |
denotes |
Their results are significantly different from ours. |
T14047 |
3441-3446 |
PRP$ |
denotes |
Their |
T14048 |
3447-3454 |
NNS |
denotes |
results |
T14049 |
3455-3458 |
VBP |
denotes |
are |
T14050 |
3459-3472 |
RB |
denotes |
significantly |
T14051 |
3473-3482 |
JJ |
denotes |
different |
T14052 |
3483-3487 |
IN |
denotes |
from |
T14053 |
3488-3492 |
PRP |
denotes |
ours |
T14054 |
3492-3493 |
. |
denotes |
. |
T14055 |
3493-3689 |
sentence |
denotes |
They see no proprioceptive afferents in the periphery of the double knockouts and note that central proprioceptive afferents terminate in the intermediate spinal cord without extending ventrally. |
T14056 |
3494-3498 |
PRP |
denotes |
They |
T14057 |
3499-3502 |
VBP |
denotes |
see |
T14058 |
3503-3505 |
DT |
denotes |
no |
T14059 |
3521-3530 |
NNS |
denotes |
afferents |
T14060 |
3506-3520 |
JJ |
denotes |
proprioceptive |
T14061 |
3531-3533 |
IN |
denotes |
in |
T14062 |
3534-3537 |
DT |
denotes |
the |
T14063 |
3538-3547 |
NN |
denotes |
periphery |
T14064 |
3548-3550 |
IN |
denotes |
of |
T14065 |
3551-3554 |
DT |
denotes |
the |
T14066 |
3562-3571 |
NNS |
denotes |
knockouts |
T14067 |
3555-3561 |
JJ |
denotes |
double |
T14068 |
3572-3575 |
CC |
denotes |
and |
T14069 |
3576-3580 |
VBP |
denotes |
note |
T14070 |
3581-3585 |
IN |
denotes |
that |
T14071 |
3619-3628 |
VBP |
denotes |
terminate |
T14072 |
3586-3593 |
JJ |
denotes |
central |
T14073 |
3609-3618 |
NNS |
denotes |
afferents |
T14074 |
3594-3608 |
JJ |
denotes |
proprioceptive |
T14075 |
3629-3631 |
IN |
denotes |
in |
T14076 |
3632-3635 |
DT |
denotes |
the |
T14077 |
3656-3660 |
NN |
denotes |
cord |
T14078 |
3636-3648 |
JJ |
denotes |
intermediate |
T14079 |
3649-3655 |
JJ |
denotes |
spinal |
T14080 |
3661-3668 |
IN |
denotes |
without |
T14081 |
3669-3678 |
VBG |
denotes |
extending |
T14082 |
3679-3688 |
RB |
denotes |
ventrally |
T14083 |
3688-3689 |
. |
denotes |
. |
T14084 |
3689-3782 |
sentence |
denotes |
Their observations are based on PV immunostaining and DiI labeling of the peripheral nerves. |
T14085 |
3690-3695 |
PRP$ |
denotes |
Their |
T14086 |
3696-3708 |
NNS |
denotes |
observations |
T14087 |
3713-3718 |
VBN |
denotes |
based |
T14088 |
3709-3712 |
VBP |
denotes |
are |
T14089 |
3719-3721 |
IN |
denotes |
on |
T14090 |
3722-3724 |
NN |
denotes |
PV |
T14091 |
3725-3739 |
NN |
denotes |
immunostaining |
T14092 |
3740-3743 |
CC |
denotes |
and |
T14093 |
3744-3747 |
NN |
denotes |
DiI |
T14094 |
3748-3756 |
NN |
denotes |
labeling |
T14095 |
3757-3759 |
IN |
denotes |
of |
T14096 |
3760-3763 |
DT |
denotes |
the |
T14097 |
3775-3781 |
NNS |
denotes |
nerves |
T14098 |
3764-3774 |
JJ |
denotes |
peripheral |
T14099 |
3781-3782 |
. |
denotes |
. |
T14100 |
3782-3856 |
sentence |
denotes |
We noted that PV immunolabeling is diminished in our Bax/NT-3 double KOs. |
T14101 |
3783-3785 |
PRP |
denotes |
We |
T14102 |
3786-3791 |
VBD |
denotes |
noted |
T14103 |
3792-3796 |
IN |
denotes |
that |
T14104 |
3815-3817 |
VBZ |
denotes |
is |
T14105 |
3797-3799 |
NN |
denotes |
PV |
T14106 |
3800-3814 |
NN |
denotes |
immunolabeling |
T14107 |
3818-3828 |
JJ |
denotes |
diminished |
T14108 |
3829-3831 |
IN |
denotes |
in |
T14109 |
3832-3835 |
PRP$ |
denotes |
our |
T14110 |
3852-3855 |
NNS |
denotes |
KOs |
T14111 |
3836-3839 |
NN |
denotes |
Bax |
T14112 |
3839-3840 |
HYPH |
denotes |
/ |
T14113 |
3840-3842 |
NN |
denotes |
NT |
T14114 |
3842-3843 |
HYPH |
denotes |
- |
T14115 |
3843-3844 |
CD |
denotes |
3 |
T14116 |
3845-3851 |
JJ |
denotes |
double |
T14117 |
3855-3856 |
. |
denotes |
. |
T14118 |
3856-4228 |
sentence |
denotes |
In various manipulations of the neurotrophins it has been noted that molecular markers for proprioceptive axons such as PV or calcitonin gene-related peptide for nerve growth factor–responsive axons are compromised (Ringstedt et al. 1997; Patel et al. 2000), thus PV immunostaining in Bax/NT-3 double KOs cannot reveal the extent of proprioceptive axons in the periphery. |
T14119 |
3857-3859 |
IN |
denotes |
In |
T14120 |
3915-3920 |
VBN |
denotes |
noted |
T14121 |
3860-3867 |
JJ |
denotes |
various |
T14122 |
3868-3881 |
NNS |
denotes |
manipulations |
T14123 |
3882-3884 |
IN |
denotes |
of |
T14124 |
3885-3888 |
DT |
denotes |
the |
T14125 |
3889-3902 |
NNS |
denotes |
neurotrophins |
T14126 |
3903-3905 |
PRP |
denotes |
it |
T14127 |
3906-3909 |
VBZ |
denotes |
has |
T14128 |
3910-3914 |
VBN |
denotes |
been |
T14129 |
4169-4175 |
VB |
denotes |
reveal |
T14130 |
3921-3925 |
IN |
denotes |
that |
T14131 |
4056-4059 |
VBP |
denotes |
are |
T14132 |
3926-3935 |
JJ |
denotes |
molecular |
T14133 |
3936-3943 |
NNS |
denotes |
markers |
T14134 |
3944-3947 |
IN |
denotes |
for |
T14135 |
3948-3962 |
JJ |
denotes |
proprioceptive |
T14136 |
3963-3968 |
NNS |
denotes |
axons |
T14137 |
3969-3973 |
JJ |
denotes |
such |
T14138 |
3974-3976 |
IN |
denotes |
as |
T14139 |
3977-3979 |
NN |
denotes |
PV |
T14140 |
3980-3982 |
CC |
denotes |
or |
T14141 |
3983-3993 |
NN |
denotes |
calcitonin |
T14142 |
4007-4014 |
NN |
denotes |
peptide |
T14143 |
3994-3998 |
NN |
denotes |
gene |
T14144 |
3999-4006 |
VBN |
denotes |
related |
T14145 |
3998-3999 |
HYPH |
denotes |
- |
T14146 |
4015-4018 |
IN |
denotes |
for |
T14147 |
4019-4024 |
NN |
denotes |
nerve |
T14148 |
4050-4055 |
NNS |
denotes |
axons |
T14149 |
4025-4031 |
NN |
denotes |
growth |
T14150 |
4032-4038 |
NN |
denotes |
factor |
T14151 |
4039-4049 |
JJ |
denotes |
responsive |
T14152 |
4038-4039 |
HYPH |
denotes |
– |
T14153 |
4060-4071 |
JJ |
denotes |
compromised |
T14154 |
4072-4073 |
-LRB- |
denotes |
( |
T14155 |
4073-4082 |
NNP |
denotes |
Ringstedt |
T14156 |
4083-4085 |
FW |
denotes |
et |
T14157 |
4086-4089 |
FW |
denotes |
al. |
T14158 |
4090-4094 |
CD |
denotes |
1997 |
T14159 |
4094-4095 |
: |
denotes |
; |
T14160 |
4096-4101 |
NNP |
denotes |
Patel |
T14161 |
4102-4104 |
FW |
denotes |
et |
T14162 |
4105-4108 |
FW |
denotes |
al. |
T14163 |
4109-4113 |
CD |
denotes |
2000 |
T14164 |
4113-4114 |
-RRB- |
denotes |
) |
T14165 |
4114-4116 |
, |
denotes |
, |
T14166 |
4116-4120 |
RB |
denotes |
thus |
T14167 |
4121-4123 |
NN |
denotes |
PV |
T14168 |
4124-4138 |
NN |
denotes |
immunostaining |
T14169 |
4139-4141 |
IN |
denotes |
in |
T14170 |
4142-4145 |
NN |
denotes |
Bax |
T14171 |
4158-4161 |
NNS |
denotes |
KOs |
T14172 |
4145-4146 |
HYPH |
denotes |
/ |
T14173 |
4146-4148 |
NN |
denotes |
NT |
T14174 |
4148-4149 |
HYPH |
denotes |
- |
T14175 |
4149-4150 |
CD |
denotes |
3 |
T14176 |
4151-4157 |
JJ |
denotes |
double |
T14177 |
4162-4165 |
MD |
denotes |
can |
T14178 |
4165-4168 |
RB |
denotes |
not |
T14179 |
4176-4179 |
DT |
denotes |
the |
T14180 |
4180-4186 |
NN |
denotes |
extent |
T14181 |
4187-4189 |
IN |
denotes |
of |
T14182 |
4190-4204 |
JJ |
denotes |
proprioceptive |
T14183 |
4205-4210 |
NNS |
denotes |
axons |
T14184 |
4211-4213 |
IN |
denotes |
in |
T14185 |
4214-4217 |
DT |
denotes |
the |
T14186 |
4218-4227 |
NN |
denotes |
periphery |
T14187 |
4227-4228 |
. |
denotes |
. |
T14188 |
4228-4461 |
sentence |
denotes |
Seventy-three percent of retrogradely labeled gastrocnemius muscle afferents were reported to be expressing TrkC RNA in the adult rat DRG, although some of these (about 10%) may represent cutaneous innervation (McMahon et al. 1994). |
T14189 |
4229-4236 |
CD |
denotes |
Seventy |
T14190 |
4237-4242 |
CD |
denotes |
three |
T14191 |
4236-4237 |
HYPH |
denotes |
- |
T14192 |
4243-4250 |
NN |
denotes |
percent |
T14193 |
4311-4319 |
VBN |
denotes |
reported |
T14194 |
4251-4253 |
IN |
denotes |
of |
T14195 |
4254-4266 |
RB |
denotes |
retrogradely |
T14196 |
4267-4274 |
VBN |
denotes |
labeled |
T14197 |
4296-4305 |
NNS |
denotes |
afferents |
T14198 |
4275-4288 |
NN |
denotes |
gastrocnemius |
T14199 |
4289-4295 |
NN |
denotes |
muscle |
T14200 |
4306-4310 |
VBD |
denotes |
were |
T14201 |
4320-4322 |
TO |
denotes |
to |
T14202 |
4326-4336 |
VBG |
denotes |
expressing |
T14203 |
4323-4325 |
VB |
denotes |
be |
T14204 |
4337-4341 |
NN |
denotes |
TrkC |
T14205 |
4342-4345 |
NN |
denotes |
RNA |
T14206 |
4346-4348 |
IN |
denotes |
in |
T14207 |
4349-4352 |
DT |
denotes |
the |
T14208 |
4363-4366 |
NN |
denotes |
DRG |
T14209 |
4353-4358 |
JJ |
denotes |
adult |
T14210 |
4359-4362 |
NN |
denotes |
rat |
T14211 |
4366-4368 |
, |
denotes |
, |
T14212 |
4368-4376 |
IN |
denotes |
although |
T14213 |
4407-4416 |
VB |
denotes |
represent |
T14214 |
4377-4381 |
DT |
denotes |
some |
T14215 |
4382-4384 |
IN |
denotes |
of |
T14216 |
4385-4390 |
DT |
denotes |
these |
T14217 |
4391-4392 |
-LRB- |
denotes |
( |
T14218 |
4392-4397 |
RB |
denotes |
about |
T14219 |
4398-4400 |
CD |
denotes |
10 |
T14220 |
4400-4401 |
NN |
denotes |
% |
T14221 |
4401-4402 |
-RRB- |
denotes |
) |
T14222 |
4403-4406 |
MD |
denotes |
may |
T14223 |
4417-4426 |
JJ |
denotes |
cutaneous |
T14224 |
4427-4438 |
NN |
denotes |
innervation |
T14225 |
4439-4440 |
-LRB- |
denotes |
( |
T14226 |
4440-4447 |
NNP |
denotes |
McMahon |
T14227 |
4448-4450 |
FW |
denotes |
et |
T14228 |
4451-4454 |
FW |
denotes |
al. |
T14229 |
4455-4459 |
CD |
denotes |
1994 |
T14230 |
4459-4460 |
-RRB- |
denotes |
) |
T14231 |
4460-4461 |
. |
denotes |
. |
T14232 |
4461-4631 |
sentence |
denotes |
Presently, it is not clear whether TrkC protein is also made by cutaneous afferents and if so at what stage in development this receptor is expressed by cutaneous axons. |
T14233 |
4462-4471 |
RB |
denotes |
Presently |
T14234 |
4476-4478 |
VBZ |
denotes |
is |
T14235 |
4471-4473 |
, |
denotes |
, |
T14236 |
4473-4475 |
PRP |
denotes |
it |
T14237 |
4479-4482 |
RB |
denotes |
not |
T14238 |
4483-4488 |
JJ |
denotes |
clear |
T14239 |
4489-4496 |
IN |
denotes |
whether |
T14240 |
4518-4522 |
VBN |
denotes |
made |
T14241 |
4497-4501 |
NN |
denotes |
TrkC |
T14242 |
4502-4509 |
NN |
denotes |
protein |
T14243 |
4510-4512 |
VBZ |
denotes |
is |
T14244 |
4513-4517 |
RB |
denotes |
also |
T14245 |
4523-4525 |
IN |
denotes |
by |
T14246 |
4526-4535 |
JJ |
denotes |
cutaneous |
T14247 |
4536-4545 |
NNS |
denotes |
afferents |
T14248 |
4546-4549 |
CC |
denotes |
and |
T14249 |
4550-4552 |
IN |
denotes |
if |
T14250 |
4553-4555 |
RB |
denotes |
so |
T14251 |
4602-4611 |
VBN |
denotes |
expressed |
T14252 |
4556-4558 |
IN |
denotes |
at |
T14253 |
4559-4563 |
WDT |
denotes |
what |
T14254 |
4564-4569 |
NN |
denotes |
stage |
T14255 |
4570-4572 |
IN |
denotes |
in |
T14256 |
4573-4584 |
NN |
denotes |
development |
T14257 |
4585-4589 |
DT |
denotes |
this |
T14258 |
4590-4598 |
NN |
denotes |
receptor |
T14259 |
4599-4601 |
VBZ |
denotes |
is |
T14260 |
4612-4614 |
IN |
denotes |
by |
T14261 |
4615-4624 |
JJ |
denotes |
cutaneous |
T14262 |
4625-4630 |
NNS |
denotes |
axons |
T14263 |
4630-4631 |
. |
denotes |
. |
T14264 |
4631-4876 |
sentence |
denotes |
Based on the available evidence showing that all proprioceptive neurons are eliminated in NT-3 or TrkC null mice, we think that TrkC staining in the tibial nerve mostly represents proprioceptive axons in the vicinity of their peripheral target. |
T14265 |
4632-4637 |
VBN |
denotes |
Based |
T14266 |
4749-4754 |
VBP |
denotes |
think |
T14267 |
4638-4640 |
IN |
denotes |
on |
T14268 |
4641-4644 |
DT |
denotes |
the |
T14269 |
4655-4663 |
NN |
denotes |
evidence |
T14270 |
4645-4654 |
JJ |
denotes |
available |
T14271 |
4664-4671 |
VBG |
denotes |
showing |
T14272 |
4672-4676 |
IN |
denotes |
that |
T14273 |
4708-4718 |
VBN |
denotes |
eliminated |
T14274 |
4677-4680 |
DT |
denotes |
all |
T14275 |
4696-4703 |
NNS |
denotes |
neurons |
T14276 |
4681-4695 |
JJ |
denotes |
proprioceptive |
T14277 |
4704-4707 |
VBP |
denotes |
are |
T14278 |
4719-4721 |
IN |
denotes |
in |
T14279 |
4722-4724 |
NN |
denotes |
NT |
T14280 |
4735-4739 |
JJ |
denotes |
null |
T14281 |
4724-4725 |
HYPH |
denotes |
- |
T14282 |
4725-4726 |
CD |
denotes |
3 |
T14283 |
4727-4729 |
CC |
denotes |
or |
T14284 |
4730-4734 |
NN |
denotes |
TrkC |
T14285 |
4740-4744 |
NNS |
denotes |
mice |
T14286 |
4744-4746 |
, |
denotes |
, |
T14287 |
4746-4748 |
PRP |
denotes |
we |
T14288 |
4755-4759 |
IN |
denotes |
that |
T14289 |
4801-4811 |
VBZ |
denotes |
represents |
T14290 |
4760-4764 |
NN |
denotes |
TrkC |
T14291 |
4765-4773 |
NN |
denotes |
staining |
T14292 |
4774-4776 |
IN |
denotes |
in |
T14293 |
4777-4780 |
DT |
denotes |
the |
T14294 |
4788-4793 |
NN |
denotes |
nerve |
T14295 |
4781-4787 |
JJ |
denotes |
tibial |
T14296 |
4794-4800 |
RB |
denotes |
mostly |
T14297 |
4812-4826 |
JJ |
denotes |
proprioceptive |
T14298 |
4827-4832 |
NNS |
denotes |
axons |
T14299 |
4833-4835 |
IN |
denotes |
in |
T14300 |
4836-4839 |
DT |
denotes |
the |
T14301 |
4840-4848 |
NN |
denotes |
vicinity |
T14302 |
4849-4851 |
IN |
denotes |
of |
T14303 |
4852-4857 |
PRP$ |
denotes |
their |
T14304 |
4869-4875 |
NN |
denotes |
target |
T14305 |
4858-4868 |
JJ |
denotes |
peripheral |
T14306 |
4875-4876 |
. |
denotes |
. |
T14307 |
4876-5018 |
sentence |
denotes |
Altogether, our findings suggest a role for NT-3 in initiation of muscle innervation and spindle differentiation by the proprioceptive axons. |
T14308 |
4877-4887 |
RB |
denotes |
Altogether |
T14309 |
4902-4909 |
VBP |
denotes |
suggest |
T14310 |
4887-4889 |
, |
denotes |
, |
T14311 |
4889-4892 |
PRP$ |
denotes |
our |
T14312 |
4893-4901 |
NNS |
denotes |
findings |
T14313 |
4910-4911 |
DT |
denotes |
a |
T14314 |
4912-4916 |
NN |
denotes |
role |
T14315 |
4917-4920 |
IN |
denotes |
for |
T14316 |
4921-4923 |
NN |
denotes |
NT |
T14317 |
4923-4924 |
HYPH |
denotes |
- |
T14318 |
4924-4925 |
CD |
denotes |
3 |
T14319 |
4926-4928 |
IN |
denotes |
in |
T14320 |
4929-4939 |
NN |
denotes |
initiation |
T14321 |
4940-4942 |
IN |
denotes |
of |
T14322 |
4943-4949 |
NN |
denotes |
muscle |
T14323 |
4950-4961 |
NN |
denotes |
innervation |
T14324 |
4962-4965 |
CC |
denotes |
and |
T14325 |
4966-4973 |
NN |
denotes |
spindle |
T14326 |
4974-4989 |
NN |
denotes |
differentiation |
T14327 |
4990-4992 |
IN |
denotes |
by |
T14328 |
4993-4996 |
DT |
denotes |
the |
T14329 |
5012-5017 |
NNS |
denotes |
axons |
T14330 |
4997-5011 |
JJ |
denotes |
proprioceptive |
T14331 |
5017-5018 |
. |
denotes |
. |
T14332 |
5018-5239 |
sentence |
denotes |
Patel et al. (2003) examined DiI-labeled central DRG axons in the spinal cord of three E17 and two P0 cases, and report that central proprioceptive axons stop in the intermediate laminae, never entering the ventral cord. |
T14333 |
5019-5024 |
NNP |
denotes |
Patel |
T14334 |
5039-5047 |
VBN |
denotes |
examined |
T14335 |
5025-5027 |
FW |
denotes |
et |
T14336 |
5028-5031 |
FW |
denotes |
al. |
T14337 |
5032-5033 |
-LRB- |
denotes |
( |
T14338 |
5033-5037 |
CD |
denotes |
2003 |
T14339 |
5037-5038 |
-RRB- |
denotes |
) |
T14340 |
5048-5051 |
NN |
denotes |
DiI |
T14341 |
5052-5059 |
VBN |
denotes |
labeled |
T14342 |
5051-5052 |
HYPH |
denotes |
- |
T14343 |
5072-5077 |
NNS |
denotes |
axons |
T14344 |
5060-5067 |
JJ |
denotes |
central |
T14345 |
5068-5071 |
NN |
denotes |
DRG |
T14346 |
5078-5080 |
IN |
denotes |
in |
T14347 |
5081-5084 |
DT |
denotes |
the |
T14348 |
5092-5096 |
NN |
denotes |
cord |
T14349 |
5085-5091 |
JJ |
denotes |
spinal |
T14350 |
5097-5099 |
IN |
denotes |
of |
T14351 |
5100-5105 |
CD |
denotes |
three |
T14352 |
5106-5109 |
NN |
denotes |
E17 |
T14425 |
5456-5458 |
IN |
denotes |
at |
T14426 |
5500-5504 |
VB |
denotes |
have |
T14427 |
5459-5465 |
JJR |
denotes |
higher |
T14428 |
5466-5479 |
NN |
denotes |
magnification |
T14429 |
5480-5485 |
DT |
denotes |
these |
T14430 |
5486-5491 |
NNS |
denotes |
axons |
T14431 |
5492-5495 |
VBD |
denotes |
did |
T14432 |
5496-5499 |
RB |
denotes |
not |
T14433 |
5505-5513 |
JJ |
denotes |
terminal |
T14434 |
5514-5521 |
NNS |
denotes |
boutons |
T14435 |
5522-5525 |
CC |
denotes |
and |
T14436 |
5526-5530 |
VBD |
denotes |
were |
T14437 |
5546-5553 |
VBN |
denotes |
labeled |
T14438 |
5531-5534 |
RB |
denotes |
not |
T14439 |
5535-5545 |
RB |
denotes |
completely |
T14440 |
5553-5554 |
. |
denotes |
. |
T14441 |
5554-5754 |
sentence |
denotes |
However, with complete fills (n = 5), it was possible to trace these axons into the ventral midline and across to the contralateral side, and visualize terminal boutons at their tips (see Figure 3C). |
T14442 |
5555-5562 |
RB |
denotes |
However |
T14443 |
5596-5599 |
VBD |
denotes |
was |
T14444 |
5562-5564 |
, |
denotes |
, |
T14445 |
5564-5568 |
IN |
denotes |
with |
T14446 |
5569-5577 |
JJ |
denotes |
complete |
T14447 |
5578-5583 |
NNS |
denotes |
fills |
T14448 |
5584-5585 |
-LRB- |
denotes |
( |
T14449 |
5589-5590 |
CD |
denotes |
5 |
T14450 |
5585-5586 |
NN |
denotes |
n |
T14451 |
5587-5588 |
SYM |
denotes |
= |
T14452 |
5590-5591 |
-RRB- |
denotes |
) |
T14453 |
5591-5593 |
, |
denotes |
, |
T14454 |
5593-5595 |
PRP |
denotes |
it |
T14455 |
5600-5608 |
JJ |
denotes |
possible |
T14456 |
5609-5611 |
TO |
denotes |
to |
T14457 |
5612-5617 |
VB |
denotes |
trace |
T14458 |
5618-5623 |
DT |
denotes |
these |
T14459 |
5624-5629 |
NNS |
denotes |
axons |
T14460 |
5630-5634 |
IN |
denotes |
into |
T14461 |
5635-5638 |
DT |
denotes |
the |
T14462 |
5647-5654 |
NN |
denotes |
midline |
T14463 |
5639-5646 |
JJ |
denotes |
ventral |
T14464 |
5655-5658 |
CC |
denotes |
and |
T14465 |
5659-5665 |
IN |
denotes |
across |
T14466 |
5666-5668 |
IN |
denotes |
to |
T14467 |
5669-5672 |
DT |
denotes |
the |
T14468 |
5687-5691 |
NN |
denotes |
side |
T14469 |
5673-5686 |
JJ |
denotes |
contralateral |
T14470 |
5691-5693 |
, |
denotes |
, |
T14471 |
5693-5696 |
CC |
denotes |
and |
T14472 |
5697-5706 |
VB |
denotes |
visualize |
T14473 |
5707-5715 |
JJ |
denotes |
terminal |
T14474 |
5716-5723 |
NNS |
denotes |
boutons |
T14475 |
5724-5726 |
IN |
denotes |
at |
T14476 |
5727-5732 |
PRP$ |
denotes |
their |
T14477 |
5733-5737 |
NNS |
denotes |
tips |
T14478 |
5738-5739 |
-LRB- |
denotes |
( |
T14479 |
5739-5742 |
VB |
denotes |
see |
T14480 |
5743-5749 |
NN |
denotes |
Figure |
T14481 |
5750-5752 |
NN |
denotes |
3C |
T14482 |
5752-5753 |
-RRB- |
denotes |
) |
T14483 |
5753-5754 |
. |
denotes |
. |
T14484 |
5754-5953 |
sentence |
denotes |
Previously, Arber et al. (2000) reported that members of the Ets family of transcription factors, Er81 and Pea3, are expressed by DRG neurons as well as motor neurons and their target muscle fibers. |
T14485 |
5755-5765 |
RB |
denotes |
Previously |
T14486 |
5787-5795 |
VBD |
denotes |
reported |
T14487 |
5765-5767 |
, |
denotes |
, |
T14488 |
5767-5772 |
NNP |
denotes |
Arber |
T14489 |
5773-5775 |
FW |
denotes |
et |
T14490 |
5776-5779 |
FW |
denotes |
al. |
T14491 |
5780-5781 |
-LRB- |
denotes |
( |
T14492 |
5781-5785 |
CD |
denotes |
2000 |
T14493 |
5785-5786 |
-RRB- |
denotes |
) |
T14494 |
5796-5800 |
IN |
denotes |
that |
T14495 |
5872-5881 |
VBN |
denotes |
expressed |
T14496 |
5801-5808 |
NNS |
denotes |
members |
T14497 |
5809-5811 |
IN |
denotes |
of |
T14498 |
5812-5815 |
DT |
denotes |
the |
T14499 |
5820-5826 |
NN |
denotes |
family |
T14500 |
5816-5819 |
NN |
denotes |
Ets |
T14501 |
5827-5829 |
IN |
denotes |
of |
T14502 |
5830-5843 |
NN |
denotes |
transcription |
T14503 |
5844-5851 |
NNS |
denotes |
factors |
T14504 |
5851-5853 |
, |
denotes |
, |
T14505 |
5853-5857 |
NN |
denotes |
Er81 |
T14506 |
5858-5861 |
CC |
denotes |
and |
T14507 |
5862-5866 |
NN |
denotes |
Pea3 |
T14508 |
5866-5868 |
, |
denotes |
, |
T14509 |
5868-5871 |
VBP |
denotes |
are |
T14510 |
5882-5884 |
IN |
denotes |
by |
T14511 |
5885-5888 |
NN |
denotes |
DRG |
T14512 |
5889-5896 |
NNS |
denotes |
neurons |
T14513 |
5897-5899 |
RB |
denotes |
as |
T14514 |
5905-5907 |
IN |
denotes |
as |
T14515 |
5900-5904 |
RB |
denotes |
well |
T14516 |
5908-5913 |
NN |
denotes |
motor |
T14517 |
5914-5921 |
NNS |
denotes |
neurons |
T14518 |
5922-5925 |
CC |
denotes |
and |
T14519 |
5926-5931 |
PRP$ |
denotes |
their |
T14520 |
5946-5952 |
NNS |
denotes |
fibers |
T14521 |
5932-5938 |
NN |
denotes |
target |
T14522 |
5939-5945 |
NN |
denotes |
muscle |
T14523 |
5952-5953 |
. |
denotes |
. |
T14524 |
5953-6117 |
sentence |
denotes |
They found that in the spinal cord of Er81 KO mice, ventral projections of proprioceptive axons were mostly absent, and very few axons made it to the ventral cord. |
T14525 |
5954-5958 |
PRP |
denotes |
They |
T14526 |
5959-5964 |
VBD |
denotes |
found |
T14527 |
5965-5969 |
IN |
denotes |
that |
T14528 |
6050-6054 |
VBD |
denotes |
were |
T14529 |
5970-5972 |
IN |
denotes |
in |
T14530 |
5973-5976 |
DT |
denotes |
the |
T14531 |
5984-5988 |
NN |
denotes |
cord |
T14532 |
5977-5983 |
JJ |
denotes |
spinal |
T14533 |
5989-5991 |
IN |
denotes |
of |
T14534 |
5992-5996 |
NN |
denotes |
Er81 |
T14535 |
5997-5999 |
NN |
denotes |
KO |
T14536 |
6000-6004 |
NNS |
denotes |
mice |
T14537 |
6004-6006 |
, |
denotes |
, |
T14538 |
6006-6013 |
JJ |
denotes |
ventral |
T14539 |
6014-6025 |
NNS |
denotes |
projections |
T14540 |
6026-6028 |
IN |
denotes |
of |
T14541 |
6029-6043 |
JJ |
denotes |
proprioceptive |
T14542 |
6044-6049 |
NNS |
denotes |
axons |
T14543 |
6055-6061 |
RB |
denotes |
mostly |
T14544 |
6062-6068 |
JJ |
denotes |
absent |
T14545 |
6068-6070 |
, |
denotes |
, |
T14546 |
6070-6073 |
CC |
denotes |
and |
T14547 |
6074-6078 |
RB |
denotes |
very |
T14548 |
6083-6088 |
NNS |
denotes |
axons |
T14549 |
6079-6082 |
JJ |
denotes |
few |
T14550 |
6089-6093 |
VBD |
denotes |
made |
T14551 |
6094-6096 |
PRP |
denotes |
it |
T14552 |
6097-6099 |
IN |
denotes |
to |
T14553 |
6100-6103 |
DT |
denotes |
the |
T14554 |
6112-6116 |
NN |
denotes |
cord |
T14555 |
6104-6111 |
JJ |
denotes |
ventral |
T14556 |
6116-6117 |
. |
denotes |
. |
T14557 |
6117-6250 |
sentence |
denotes |
Patel et al. (2003) note that the phenotype they observed in their Bax/NT-3 double KO mice is quite similar to that of Er81 KO mice. |
T14558 |
6118-6123 |
NNP |
denotes |
Patel |
T14559 |
6138-6142 |
VBP |
denotes |
note |
T14560 |
6124-6126 |
FW |
denotes |
et |
T14561 |
6127-6130 |
FW |
denotes |
al. |
T14562 |
6131-6132 |
-LRB- |
denotes |
( |
T14563 |
6132-6136 |
CD |
denotes |
2003 |
T14564 |
6136-6137 |
-RRB- |
denotes |
) |
T14565 |
6143-6147 |
IN |
denotes |
that |
T14566 |
6209-6211 |
VBZ |
denotes |
is |
T14567 |
6148-6151 |
DT |
denotes |
the |
T14568 |
6152-6161 |
NN |
denotes |
phenotype |
T14569 |
6162-6166 |
PRP |
denotes |
they |
T14570 |
6167-6175 |
VBD |
denotes |
observed |
T14571 |
6176-6178 |
IN |
denotes |
in |
T14572 |
6179-6184 |
PRP$ |
denotes |
their |
T14573 |
6204-6208 |
NNS |
denotes |
mice |
T14574 |
6185-6188 |
NN |
denotes |
Bax |
T14575 |
6201-6203 |
NN |
denotes |
KO |
T14576 |
6188-6189 |
HYPH |
denotes |
/ |
T14577 |
6189-6191 |
NN |
denotes |
NT |
T14578 |
6191-6192 |
HYPH |
denotes |
- |
T14579 |
6192-6193 |
CD |
denotes |
3 |
T14580 |
6194-6200 |
JJ |
denotes |
double |
T14581 |
6212-6217 |
RB |
denotes |
quite |
T14582 |
6218-6225 |
JJ |
denotes |
similar |
T14583 |
6226-6228 |
IN |
denotes |
to |
T14584 |
6229-6233 |
DT |
denotes |
that |
T14585 |
6234-6236 |
IN |
denotes |
of |
T14586 |
6237-6241 |
NN |
denotes |
Er81 |
T14587 |
6242-6244 |
NN |
denotes |
KO |
T14588 |
6245-6249 |
NNS |
denotes |
mice |
T14589 |
6249-6250 |
. |
denotes |
. |
T14590 |
6250-6332 |
sentence |
denotes |
They provide evidence that NT-3 induces Er81 expression in DRG explants in vitro. |
T14591 |
6251-6255 |
PRP |
denotes |
They |
T14592 |
6256-6263 |
VBP |
denotes |
provide |
T14593 |
6264-6272 |
NN |
denotes |
evidence |
T14594 |
6273-6277 |
IN |
denotes |
that |
T14595 |
6283-6290 |
VBZ |
denotes |
induces |
T14596 |
6278-6280 |
NN |
denotes |
NT |
T14597 |
6280-6281 |
HYPH |
denotes |
- |
T14598 |
6281-6282 |
CD |
denotes |
3 |
T14599 |
6291-6295 |
NN |
denotes |
Er81 |
T14600 |
6296-6306 |
NN |
denotes |
expression |
T14601 |
6307-6309 |
IN |
denotes |
in |
T14602 |
6310-6313 |
NN |
denotes |
DRG |
T14603 |
6314-6322 |
NNS |
denotes |
explants |
T14604 |
6323-6325 |
FW |
denotes |
in |
T14605 |
6326-6331 |
FW |
denotes |
vitro |
T14606 |
6331-6332 |
. |
denotes |
. |
T14607 |
6332-6555 |
sentence |
denotes |
Patel et al. (2003) report that Er81 mRNA expression is diminished (but not abolished) in both NT-3 KO and Bax/NT-3 double KO mice, while their immunohistochemistry shows much less protein expression in the double KO mice. |
T14608 |
6333-6338 |
NNP |
denotes |
Patel |
T14609 |
6353-6359 |
VBP |
denotes |
report |
T14610 |
6339-6341 |
FW |
denotes |
et |
T14611 |
6342-6345 |
FW |
denotes |
al. |
T14612 |
6346-6347 |
-LRB- |
denotes |
( |
T14613 |
6347-6351 |
CD |
denotes |
2003 |
T14614 |
6351-6352 |
-RRB- |
denotes |
) |
T14615 |
6360-6364 |
IN |
denotes |
that |
T14616 |
6389-6399 |
VBN |
denotes |
diminished |
T14617 |
6365-6369 |
NN |
denotes |
Er81 |
T14618 |
6375-6385 |
NN |
denotes |
expression |
T14619 |
6370-6374 |
NN |
denotes |
mRNA |
T14620 |
6386-6388 |
VBZ |
denotes |
is |
T14621 |
6400-6401 |
-LRB- |
denotes |
( |
T14622 |
6401-6404 |
CC |
denotes |
but |
T14623 |
6405-6408 |
RB |
denotes |
not |
T14624 |
6409-6418 |
VBN |
denotes |
abolished |
T14625 |
6418-6419 |
-RRB- |
denotes |
) |
T14626 |
6420-6422 |
IN |
denotes |
in |
T14627 |
6423-6427 |
CC |
denotes |
both |
T14628 |
6459-6463 |
NNS |
denotes |
mice |
T14629 |
6428-6430 |
NN |
denotes |
NT |
T14630 |
6433-6435 |
NN |
denotes |
KO |
T14631 |
6430-6431 |
HYPH |
denotes |
- |
T14632 |
6431-6432 |
CD |
denotes |
3 |
T14633 |
6436-6439 |
CC |
denotes |
and |
T14634 |
6440-6443 |
NN |
denotes |
Bax |
T14635 |
6456-6458 |
NN |
denotes |
KO |
T14636 |
6443-6444 |
HYPH |
denotes |
/ |
T14637 |
6444-6446 |
NN |
denotes |
NT |
T14638 |
6446-6447 |
HYPH |
denotes |
- |
T14639 |
6447-6448 |
CD |
denotes |
3 |
T14640 |
6449-6455 |
JJ |
denotes |
double |
T14641 |
6463-6465 |
, |
denotes |
, |
T14642 |
6465-6470 |
IN |
denotes |
while |
T14643 |
6498-6503 |
VBZ |
denotes |
shows |
T14644 |
6471-6476 |
PRP$ |
denotes |
their |
T14645 |
6477-6497 |
NN |
denotes |
immunohistochemistry |
T14646 |
6504-6508 |
RB |
denotes |
much |
T14647 |
6509-6513 |
JJR |
denotes |
less |
T14648 |
6522-6532 |
NN |
denotes |
expression |
T14649 |
6514-6521 |
NN |
denotes |
protein |
T14650 |
6533-6535 |
IN |
denotes |
in |
T14651 |
6536-6539 |
DT |
denotes |
the |
T14652 |
6550-6554 |
NNS |
denotes |
mice |
T14653 |
6540-6546 |
JJ |
denotes |
double |
T14654 |
6547-6549 |
NN |
denotes |
KO |
T14655 |
6554-6555 |
. |
denotes |
. |
T14656 |
6555-6769 |
sentence |
denotes |
It is highly possible that a small but considerable number of DRG cells express the transcription factor Er81 and that their axons grow beyond the intermediate levels of the spinal cord in Bax/NT-3 double KO mice. |
T14657 |
6556-6558 |
PRP |
denotes |
It |
T14658 |
6559-6561 |
VBZ |
denotes |
is |
T14659 |
6562-6568 |
RB |
denotes |
highly |
T14660 |
6569-6577 |
JJ |
denotes |
possible |
T14661 |
6578-6582 |
IN |
denotes |
that |
T14662 |
6628-6635 |
VBP |
denotes |
express |
T14663 |
6583-6584 |
DT |
denotes |
a |
T14664 |
6608-6614 |
NN |
denotes |
number |
T14665 |
6585-6590 |
JJ |
denotes |
small |
T14666 |
6591-6594 |
CC |
denotes |
but |
T14667 |
6595-6607 |
JJ |
denotes |
considerable |
T14668 |
6615-6617 |
IN |
denotes |
of |
T14669 |
6618-6621 |
NN |
denotes |
DRG |
T14670 |
6622-6627 |
NNS |
denotes |
cells |
T14671 |
6636-6639 |
DT |
denotes |
the |
T14672 |
6654-6660 |
NN |
denotes |
factor |
T14673 |
6640-6653 |
NN |
denotes |
transcription |
T14674 |
6661-6665 |
NN |
denotes |
Er81 |
T14675 |
6666-6669 |
CC |
denotes |
and |
T14676 |
6670-6674 |
IN |
denotes |
that |
T14677 |
6687-6691 |
VB |
denotes |
grow |
T14678 |
6675-6680 |
PRP$ |
denotes |
their |
T14679 |
6681-6686 |
NNS |
denotes |
axons |
T14680 |
6692-6698 |
IN |
denotes |
beyond |
T14681 |
6699-6702 |
DT |
denotes |
the |
T14682 |
6716-6722 |
NNS |
denotes |
levels |
T14683 |
6703-6715 |
JJ |
denotes |
intermediate |
T14684 |
6723-6725 |
IN |
denotes |
of |
T14685 |
6726-6729 |
DT |
denotes |
the |
T14686 |
6737-6741 |
NN |
denotes |
cord |
T14687 |
6730-6736 |
JJ |
denotes |
spinal |
T14688 |
6742-6744 |
IN |
denotes |
in |
T14689 |
6745-6748 |
NN |
denotes |
Bax |
T14690 |
6761-6763 |
NN |
denotes |
KO |
T14691 |
6748-6749 |
HYPH |
denotes |
/ |
T14692 |
6749-6751 |
NN |
denotes |
NT |
T14693 |
6751-6752 |
HYPH |
denotes |
- |
T14694 |
6752-6753 |
CD |
denotes |
3 |
T14695 |
6754-6760 |
JJ |
denotes |
double |
T14696 |
6764-6768 |
NNS |
denotes |
mice |
T14697 |
6768-6769 |
. |
denotes |
. |
T14698 |
6769-7047 |
sentence |
denotes |
While the phenotype of Er81 KO mice is quite dramatic, and most proprioceptive axons stop within the intermediate spinal cord, it is important to note that a few axons still find their way to the ventral spinal cord and target properly to the motor neurons (Arber et al. 2000). |
T14699 |
6770-6775 |
IN |
denotes |
While |
T14700 |
6806-6808 |
VBZ |
denotes |
is |
T14701 |
6776-6779 |
DT |
denotes |
the |
T14702 |
6780-6789 |
NN |
denotes |
phenotype |
T14703 |
6790-6792 |
IN |
denotes |
of |
T14704 |
6793-6797 |
NN |
denotes |
Er81 |
T14705 |
6798-6800 |
NN |
denotes |
KO |
T14706 |
6801-6805 |
NNS |
denotes |
mice |
T14707 |
6900-6902 |
VBZ |
denotes |
is |
T14708 |
6809-6814 |
RB |
denotes |
quite |
T14709 |
6815-6823 |
JJ |
denotes |
dramatic |
T14710 |
6823-6825 |
, |
denotes |
, |
T14711 |
6825-6828 |
CC |
denotes |
and |
T14712 |
6829-6833 |
JJS |
denotes |
most |
T14713 |
6849-6854 |
NNS |
denotes |
axons |
T14714 |
6834-6848 |
JJ |
denotes |
proprioceptive |
T14715 |
6855-6859 |
VB |
denotes |
stop |
T14716 |
6860-6866 |
IN |
denotes |
within |
T14717 |
6867-6870 |
DT |
denotes |
the |
T14718 |
6891-6895 |
NN |
denotes |
cord |
T14719 |
6871-6883 |
JJ |
denotes |
intermediate |
T14720 |
6884-6890 |
JJ |
denotes |
spinal |
T14721 |
6895-6897 |
, |
denotes |
, |
T14722 |
6897-6899 |
PRP |
denotes |
it |
T14723 |
6903-6912 |
JJ |
denotes |
important |
T14724 |
6913-6915 |
TO |
denotes |
to |
T14725 |
6916-6920 |
VB |
denotes |
note |
T14726 |
6921-6925 |
IN |
denotes |
that |
T14727 |
6944-6948 |
VBP |
denotes |
find |
T14728 |
6926-6927 |
DT |
denotes |
a |
T14729 |
6932-6937 |
NNS |
denotes |
axons |
T14730 |
6928-6931 |
JJ |
denotes |
few |
T14731 |
6938-6943 |
RB |
denotes |
still |
T14732 |
6949-6954 |
PRP$ |
denotes |
their |
T14733 |
6955-6958 |
NN |
denotes |
way |
T14734 |
6959-6961 |
IN |
denotes |
to |
T14735 |
6962-6965 |
DT |
denotes |
the |
T14736 |
6981-6985 |
NN |
denotes |
cord |
T14737 |
6966-6973 |
JJ |
denotes |
ventral |
T14738 |
6974-6980 |
JJ |
denotes |
spinal |
T14739 |
6986-6989 |
CC |
denotes |
and |
T14740 |
6990-6996 |
VBP |
denotes |
target |
T14741 |
6997-7005 |
RB |
denotes |
properly |
T14742 |
7006-7008 |
IN |
denotes |
to |
T14743 |
7009-7012 |
DT |
denotes |
the |
T14744 |
7019-7026 |
NNS |
denotes |
neurons |
T14745 |
7013-7018 |
NN |
denotes |
motor |
T14746 |
7027-7028 |
-LRB- |
denotes |
( |
T14747 |
7028-7033 |
NNP |
denotes |
Arber |
T14748 |
7034-7036 |
FW |
denotes |
et |
T14749 |
7037-7040 |
FW |
denotes |
al. |
T14750 |
7041-7045 |
CD |
denotes |
2000 |
T14751 |
7045-7046 |
-RRB- |
denotes |
) |
T14752 |
7046-7047 |
. |
denotes |
. |
T14753 |
7047-7189 |
sentence |
denotes |
Patel et al. (2003) also present observations from islet2DTA mice, which lack a significant portion of the motor neurons in the ventral cord. |
T14754 |
7048-7053 |
NNP |
denotes |
Patel |
T14755 |
7073-7080 |
VBP |
denotes |
present |
T14756 |
7054-7056 |
FW |
denotes |
et |
T14757 |
7057-7060 |
FW |
denotes |
al. |
T14758 |
7061-7062 |
-LRB- |
denotes |
( |
T14759 |
7062-7066 |
CD |
denotes |
2003 |
T14760 |
7066-7067 |
-RRB- |
denotes |
) |
T14761 |
7068-7072 |
RB |
denotes |
also |
T14762 |
7081-7093 |
NNS |
denotes |
observations |
T14763 |
7094-7098 |
IN |
denotes |
from |
T14764 |
7099-7108 |
NN |
denotes |
islet2DTA |
T14765 |
7109-7113 |
NNS |
denotes |
mice |
T14766 |
7113-7115 |
, |
denotes |
, |
T14767 |
7115-7120 |
WDT |
denotes |
which |
T14768 |
7121-7125 |
VBP |
denotes |
lack |
T14769 |
7126-7127 |
DT |
denotes |
a |
T14770 |
7140-7147 |
NN |
denotes |
portion |
T14771 |
7128-7139 |
JJ |
denotes |
significant |
T14772 |
7148-7150 |
IN |
denotes |
of |
T14773 |
7151-7154 |
DT |
denotes |
the |
T14774 |
7161-7168 |
NNS |
denotes |
neurons |
T14775 |
7155-7160 |
NN |
denotes |
motor |
T14776 |
7169-7171 |
IN |
denotes |
in |
T14777 |
7172-7175 |
DT |
denotes |
the |
T14778 |
7184-7188 |
NN |
denotes |
cord |
T14779 |
7176-7183 |
JJ |
denotes |
ventral |
T14780 |
7188-7189 |
. |
denotes |
. |
T14781 |
7189-7255 |
sentence |
denotes |
In these mice PV immunostaining shows axons in the ventral horns. |
T14782 |
7190-7192 |
IN |
denotes |
In |
T14783 |
7222-7227 |
VBZ |
denotes |
shows |
T14784 |
7193-7198 |
DT |
denotes |
these |
T14785 |
7199-7203 |
NNS |
denotes |
mice |
T14786 |
7204-7206 |
NN |
denotes |
PV |
T14787 |
7207-7221 |
NN |
denotes |
immunostaining |
T14788 |
7228-7233 |
NNS |
denotes |
axons |
T14789 |
7234-7236 |
IN |
denotes |
in |
T14790 |
7237-7240 |
DT |
denotes |
the |
T14791 |
7249-7254 |
NNS |
denotes |
horns |
T14792 |
7241-7248 |
JJ |
denotes |
ventral |
T14793 |
7254-7255 |
. |
denotes |
. |
T14794 |
7255-7430 |
sentence |
denotes |
Patel et al. argue that since motor neurons are absent in these mice, NT-3 secreted by them could not be a signal for proprioceptive axons to enter the lateral motor columns. |
T14795 |
7256-7261 |
NNP |
denotes |
Patel |
T14796 |
7269-7274 |
VBP |
denotes |
argue |
T14797 |
7262-7264 |
FW |
denotes |
et |
T14798 |
7265-7268 |
FW |
denotes |
al. |
T14799 |
7275-7279 |
IN |
denotes |
that |
T14800 |
7358-7360 |
VB |
denotes |
be |
T14801 |
7280-7285 |
IN |
denotes |
since |
T14802 |
7300-7303 |
VBP |
denotes |
are |
T14803 |
7286-7291 |
NN |
denotes |
motor |
T14804 |
7292-7299 |
NNS |
denotes |
neurons |
T14805 |
7304-7310 |
JJ |
denotes |
absent |
T14806 |
7311-7313 |
IN |
denotes |
in |
T14807 |
7314-7319 |
DT |
denotes |
these |
T14808 |
7320-7324 |
NNS |
denotes |
mice |
T14809 |
7324-7326 |
, |
denotes |
, |
T14810 |
7326-7328 |
NN |
denotes |
NT |
T14811 |
7328-7329 |
HYPH |
denotes |
- |
T14812 |
7329-7330 |
CD |
denotes |
3 |
T14813 |
7331-7339 |
VBN |
denotes |
secreted |
T14814 |
7340-7342 |
IN |
denotes |
by |
T14815 |
7343-7347 |
PRP |
denotes |
them |
T14816 |
7348-7353 |
MD |
denotes |
could |
T14817 |
7354-7357 |
RB |
denotes |
not |
T14818 |
7361-7362 |
DT |
denotes |
a |
T14819 |
7363-7369 |
NN |
denotes |
signal |
T14820 |
7370-7373 |
IN |
denotes |
for |
T14821 |
7398-7403 |
VB |
denotes |
enter |
T14822 |
7374-7388 |
JJ |
denotes |
proprioceptive |
T14823 |
7389-7394 |
NNS |
denotes |
axons |
T14824 |
7395-7397 |
TO |
denotes |
to |
T14825 |
7404-7407 |
DT |
denotes |
the |
T14826 |
7422-7429 |
NNS |
denotes |
columns |
T14827 |
7408-7415 |
JJ |
denotes |
lateral |
T14828 |
7416-7421 |
NN |
denotes |
motor |
T14829 |
7429-7430 |
. |
denotes |
. |
T14830 |
7430-7726 |
sentence |
denotes |
However, there is no evidence showing that NT-3 mRNA or protein expressed in the ventral spinal cord is exclusively from motor neurons, and there are no available data indicating that in islet2DTA mice, NT-3 expression in the ventral spinal cord is abolished (Yang et al. 2001; Pun et al. 2002). |
T14831 |
7431-7438 |
RB |
denotes |
However |
T14832 |
7446-7448 |
VBZ |
denotes |
is |
T14833 |
7438-7440 |
, |
denotes |
, |
T14834 |
7440-7445 |
EX |
denotes |
there |
T14835 |
7449-7451 |
DT |
denotes |
no |
T14836 |
7452-7460 |
NN |
denotes |
evidence |
T14837 |
7461-7468 |
VBG |
denotes |
showing |
T14838 |
7469-7473 |
IN |
denotes |
that |
T14839 |
7532-7534 |
VBZ |
denotes |
is |
T14840 |
7474-7476 |
NN |
denotes |
NT |
T14841 |
7479-7483 |
NN |
denotes |
mRNA |
T14842 |
7476-7477 |
HYPH |
denotes |
- |
T14843 |
7477-7478 |
CD |
denotes |
3 |
T14844 |
7484-7486 |
CC |
denotes |
or |
T14845 |
7487-7494 |
NN |
denotes |
protein |
T14846 |
7495-7504 |
VBN |
denotes |
expressed |
T14847 |
7505-7507 |
IN |
denotes |
in |
T14848 |
7508-7511 |
DT |
denotes |
the |
T14849 |
7527-7531 |
NN |
denotes |
cord |
T14850 |
7512-7519 |
JJ |
denotes |
ventral |
T14851 |
7520-7526 |
JJ |
denotes |
spinal |
T14852 |
7535-7546 |
RB |
denotes |
exclusively |
T14853 |
7547-7551 |
IN |
denotes |
from |
T14854 |
7552-7557 |
NN |
denotes |
motor |
T14855 |
7558-7565 |
NNS |
denotes |
neurons |
T14856 |
7565-7567 |
, |
denotes |
, |
T14857 |
7567-7570 |
CC |
denotes |
and |
T14858 |
7571-7576 |
EX |
denotes |
there |
T14859 |
7577-7580 |
VBP |
denotes |
are |
T14860 |
7581-7583 |
DT |
denotes |
no |
T14861 |
7594-7598 |
NNS |
denotes |
data |
T14862 |
7584-7593 |
JJ |
denotes |
available |
T14863 |
7599-7609 |
VBG |
denotes |
indicating |
T14864 |
7610-7614 |
IN |
denotes |
that |
T14865 |
7680-7689 |
VBN |
denotes |
abolished |
T14866 |
7615-7617 |
IN |
denotes |
in |
T14867 |
7618-7627 |
NN |
denotes |
islet2DTA |
T14868 |
7628-7632 |
NNS |
denotes |
mice |
T14869 |
7632-7634 |
, |
denotes |
, |
T14870 |
7634-7636 |
NN |
denotes |
NT |
T14871 |
7639-7649 |
NN |
denotes |
expression |
T14872 |
7636-7637 |
HYPH |
denotes |
- |
T14873 |
7637-7638 |
CD |
denotes |
3 |
T14874 |
7650-7652 |
IN |
denotes |
in |
T14875 |
7653-7656 |
DT |
denotes |
the |
T14876 |
7672-7676 |
NN |
denotes |
cord |
T14877 |
7657-7664 |
JJ |
denotes |
ventral |
T14878 |
7665-7671 |
JJ |
denotes |
spinal |
T14879 |
7677-7679 |
VBZ |
denotes |
is |
T14880 |
7690-7691 |
-LRB- |
denotes |
( |
T14881 |
7691-7695 |
NNP |
denotes |
Yang |
T14882 |
7696-7698 |
FW |
denotes |
et |
T14883 |
7699-7702 |
FW |
denotes |
al. |
T14884 |
7703-7707 |
CD |
denotes |
2001 |
T14885 |
7707-7708 |
: |
denotes |
; |
T14886 |
7709-7712 |
NNP |
denotes |
Pun |
T14887 |
7713-7715 |
FW |
denotes |
et |
T14888 |
7716-7719 |
FW |
denotes |
al. |
T14889 |
7720-7724 |
CD |
denotes |
2002 |
T14890 |
7724-7725 |
-RRB- |
denotes |
) |
T14891 |
7725-7726 |
. |
denotes |
. |
T14892 |
7726-7903 |
sentence |
denotes |
Studies in embryonic mice reported NT-3 mRNA in the ventral horns of the spinal cord, but it is not definitive that both mRNA and protein are expressed solely by motor neurons. |
T14893 |
7727-7734 |
NNS |
denotes |
Studies |
T14894 |
7753-7761 |
VBD |
denotes |
reported |
T14895 |
7735-7737 |
IN |
denotes |
in |
T14896 |
7738-7747 |
JJ |
denotes |
embryonic |
T14897 |
7748-7752 |
NNS |
denotes |
mice |
T14898 |
7762-7764 |
NN |
denotes |
NT |
T14899 |
7767-7771 |
NN |
denotes |
mRNA |
T14900 |
7764-7765 |
HYPH |
denotes |
- |
T14901 |
7765-7766 |
CD |
denotes |
3 |
T14902 |
7772-7774 |
IN |
denotes |
in |
T14903 |
7775-7778 |
DT |
denotes |
the |
T14904 |
7787-7792 |
NNS |
denotes |
horns |
T14905 |
7779-7786 |
JJ |
denotes |
ventral |
T14906 |
7793-7795 |
IN |
denotes |
of |
T14907 |
7796-7799 |
DT |
denotes |
the |
T14908 |
7807-7811 |
NN |
denotes |
cord |
T14909 |
7800-7806 |
JJ |
denotes |
spinal |
T14910 |
7811-7813 |
, |
denotes |
, |
T14911 |
7813-7816 |
CC |
denotes |
but |
T14912 |
7817-7819 |
PRP |
denotes |
it |
T14913 |
7820-7822 |
VBZ |
denotes |
is |
T14914 |
7823-7826 |
RB |
denotes |
not |
T14915 |
7827-7837 |
JJ |
denotes |
definitive |
T14916 |
7838-7842 |
IN |
denotes |
that |
T14917 |
7869-7878 |
VBN |
denotes |
expressed |
T14918 |
7843-7847 |
CC |
denotes |
both |
T14919 |
7848-7852 |
NN |
denotes |
mRNA |
T14920 |
7853-7856 |
CC |
denotes |
and |
T14921 |
7857-7864 |
NN |
denotes |
protein |
T14922 |
7865-7868 |
VBP |
denotes |
are |
T14923 |
7879-7885 |
RB |
denotes |
solely |
T14924 |
7886-7888 |
IN |
denotes |
by |
T14925 |
7889-7894 |
NN |
denotes |
motor |
T14926 |
7895-7902 |
NNS |
denotes |
neurons |
T14927 |
7902-7903 |
. |
denotes |
. |
T14928 |
7903-8084 |
sentence |
denotes |
In the adult spinal cord, while motor neurons express high levels of NT-3, other cells, including glia, also express it (Zhou and Rush 1994; Dreyfus et al. 1999; Buck et al. 2000). |
T14929 |
7904-7906 |
IN |
denotes |
In |
T14930 |
8013-8020 |
VBP |
denotes |
express |
T14931 |
7907-7910 |
DT |
denotes |
the |
T14932 |
7924-7928 |
NN |
denotes |
cord |
T14933 |
7911-7916 |
JJ |
denotes |
adult |
T14934 |
7917-7923 |
JJ |
denotes |
spinal |
T14935 |
7928-7930 |
, |
denotes |
, |
T14936 |
7930-7935 |
IN |
denotes |
while |
T14937 |
7950-7957 |
VBP |
denotes |
express |
T14938 |
7936-7941 |
NN |
denotes |
motor |
T14939 |
7942-7949 |
NNS |
denotes |
neurons |
T14940 |
7958-7962 |
JJ |
denotes |
high |
T14941 |
7963-7969 |
NNS |
denotes |
levels |
T14942 |
7970-7972 |
IN |
denotes |
of |
T14943 |
7973-7975 |
NN |
denotes |
NT |
T14944 |
7975-7976 |
HYPH |
denotes |
- |
T14945 |
7976-7977 |
CD |
denotes |
3 |
T14946 |
7977-7979 |
, |
denotes |
, |
T14947 |
7979-7984 |
JJ |
denotes |
other |
T14948 |
7985-7990 |
NNS |
denotes |
cells |
T14949 |
7990-7992 |
, |
denotes |
, |
T14950 |
7992-8001 |
VBG |
denotes |
including |
T14951 |
8002-8006 |
NN |
denotes |
glia |
T14952 |
8006-8008 |
, |
denotes |
, |
T14953 |
8008-8012 |
RB |
denotes |
also |
T14954 |
8021-8023 |
PRP |
denotes |
it |
T14955 |
8024-8025 |
-LRB- |
denotes |
( |
T14956 |
8025-8029 |
NNP |
denotes |
Zhou |
T14957 |
8030-8033 |
CC |
denotes |
and |
T14958 |
8034-8038 |
NNP |
denotes |
Rush |
T14959 |
8039-8043 |
CD |
denotes |
1994 |
T14960 |
8043-8044 |
: |
denotes |
; |
T14961 |
8045-8052 |
NNP |
denotes |
Dreyfus |
T14962 |
8053-8055 |
FW |
denotes |
et |
T14963 |
8056-8059 |
FW |
denotes |
al. |
T14964 |
8060-8064 |
CD |
denotes |
1999 |
T14965 |
8064-8065 |
: |
denotes |
; |
T14966 |
8066-8070 |
NNP |
denotes |
Buck |
T14967 |
8071-8073 |
FW |
denotes |
et |
T14968 |
8074-8077 |
FW |
denotes |
al. |
T14969 |
8078-8082 |
CD |
denotes |
2000 |
T14970 |
8082-8083 |
-RRB- |
denotes |
) |
T14971 |
8083-8084 |
. |
denotes |
. |
T14972 |
8084-8334 |
sentence |
denotes |
Our present results, along with those from transgenic mice with NT-3 over-expression in ectopic regions of the spinal cord (Ringstedt et al. 1997), argue for a role of NT-3 in chemoattractant axon guidance of proprioceptive axons in the spinal cord. |
T14973 |
8085-8088 |
PRP$ |
denotes |
Our |
T14974 |
8097-8104 |
NNS |
denotes |
results |
T14975 |
8089-8096 |
JJ |
denotes |
present |
T14976 |
8233-8238 |
VBP |
denotes |
argue |
T14977 |
8104-8106 |
, |
denotes |
, |
T14978 |
8106-8111 |
IN |
denotes |
along |
T14979 |
8112-8116 |
IN |
denotes |
with |
T14980 |
8117-8122 |
DT |
denotes |
those |
T14981 |
8123-8127 |
IN |
denotes |
from |
T14982 |
8128-8138 |
JJ |
denotes |
transgenic |
T14983 |
8139-8143 |
NNS |
denotes |
mice |
T14984 |
8144-8148 |
IN |
denotes |
with |
T14985 |
8149-8151 |
NN |
denotes |
NT |
T14986 |
8154-8169 |
NN |
denotes |
over-expression |
T14987 |
8151-8152 |
HYPH |
denotes |
- |
T14988 |
8152-8153 |
CD |
denotes |
3 |
T14989 |
8170-8172 |
IN |
denotes |
in |
T14990 |
8173-8180 |
JJ |
denotes |
ectopic |
T14991 |
8181-8188 |
NNS |
denotes |
regions |
T14992 |
8189-8191 |
IN |
denotes |
of |
T14993 |
8192-8195 |
DT |
denotes |
the |
T14994 |
8203-8207 |
NN |
denotes |
cord |
T14995 |
8196-8202 |
JJ |
denotes |
spinal |
T14996 |
8208-8209 |
-LRB- |
denotes |
( |
T14997 |
8209-8218 |
NNP |
denotes |
Ringstedt |
T14998 |
8219-8221 |
FW |
denotes |
et |
T14999 |
8222-8225 |
FW |
denotes |
al. |
T15000 |
8226-8230 |
CD |
denotes |
1997 |
T15001 |
8230-8231 |
-RRB- |
denotes |
) |
T15002 |
8231-8233 |
, |
denotes |
, |
T15003 |
8239-8242 |
IN |
denotes |
for |
T15004 |
8243-8244 |
DT |
denotes |
a |
T15005 |
8245-8249 |
NN |
denotes |
role |
T15006 |
8250-8252 |
IN |
denotes |
of |
T15007 |
8253-8255 |
NN |
denotes |
NT |
T15008 |
8255-8256 |
HYPH |
denotes |
- |
T15009 |
8256-8257 |
CD |
denotes |
3 |
T15010 |
8258-8260 |
IN |
denotes |
in |
T15011 |
8261-8276 |
NN |
denotes |
chemoattractant |
T15012 |
8282-8290 |
NN |
denotes |
guidance |
T15013 |
8277-8281 |
NN |
denotes |
axon |
T15014 |
8291-8293 |
IN |
denotes |
of |
T15015 |
8294-8308 |
JJ |
denotes |
proprioceptive |
T15016 |
8309-8314 |
NNS |
denotes |
axons |
T15017 |
8315-8317 |
IN |
denotes |
in |
T15018 |
8318-8321 |
DT |
denotes |
the |
T15019 |
8329-8333 |
NN |
denotes |
cord |
T15020 |
8322-8328 |
JJ |
denotes |
spinal |
T15021 |
8333-8334 |
. |
denotes |
. |
T15022 |
8334-8439 |
sentence |
denotes |
Finally, in culture assays, we see a strong chemoattraction of DRG neurons to localized sources of NT-3. |
T15023 |
8335-8342 |
RB |
denotes |
Finally |
T15024 |
8366-8369 |
VBP |
denotes |
see |
T15025 |
8342-8344 |
, |
denotes |
, |
T15026 |
8344-8346 |
IN |
denotes |
in |
T15027 |
8347-8354 |
NN |
denotes |
culture |
T15028 |
8355-8361 |
NNS |
denotes |
assays |
T15029 |
8361-8363 |
, |
denotes |
, |
T15030 |
8363-8365 |
PRP |
denotes |
we |
T15031 |
8370-8371 |
DT |
denotes |
a |
T15032 |
8379-8394 |
NN |
denotes |
chemoattraction |
T15033 |
8372-8378 |
JJ |
denotes |
strong |
T15034 |
8395-8397 |
IN |
denotes |
of |
T15035 |
8398-8401 |
NN |
denotes |
DRG |
T15036 |
8402-8409 |
NNS |
denotes |
neurons |
T15037 |
8410-8412 |
IN |
denotes |
to |
T15038 |
8413-8422 |
JJ |
denotes |
localized |
T15039 |
8423-8430 |
NNS |
denotes |
sources |
T15040 |
8431-8433 |
IN |
denotes |
of |
T15041 |
8434-8436 |
NN |
denotes |
NT |
T15042 |
8436-8437 |
HYPH |
denotes |
- |
T15043 |
8437-8438 |
CD |
denotes |
3 |
T15044 |
8438-8439 |
. |
denotes |
. |
T15045 |
8439-8596 |
sentence |
denotes |
This response is seen in WT, Bax null and in p75 null DRG explants, and in the absence of any other neurotrophins or target-derived axon guidance molecules. |
T15046 |
8440-8444 |
DT |
denotes |
This |
T15047 |
8445-8453 |
NN |
denotes |
response |
T15048 |
8457-8461 |
VBN |
denotes |
seen |
T15049 |
8454-8456 |
VBZ |
denotes |
is |
T15050 |
8462-8464 |
IN |
denotes |
in |
T15051 |
8465-8467 |
NN |
denotes |
WT |
T15052 |
8469-8472 |
NN |
denotes |
Bax |
T15053 |
8467-8469 |
, |
denotes |
, |
T15054 |
8473-8477 |
JJ |
denotes |
null |
T15055 |
8478-8481 |
CC |
denotes |
and |
T15056 |
8482-8484 |
IN |
denotes |
in |
T15057 |
8485-8488 |
NN |
denotes |
p75 |
T15058 |
8489-8493 |
JJ |
denotes |
null |
T15059 |
8494-8497 |
NN |
denotes |
DRG |
T15060 |
8498-8506 |
NNS |
denotes |
explants |
T15061 |
8506-8508 |
, |
denotes |
, |
T15062 |
8508-8511 |
CC |
denotes |
and |
T15063 |
8512-8514 |
IN |
denotes |
in |
T15064 |
8515-8518 |
DT |
denotes |
the |
T15065 |
8519-8526 |
NN |
denotes |
absence |
T15066 |
8527-8529 |
IN |
denotes |
of |
T15067 |
8530-8533 |
DT |
denotes |
any |
T15068 |
8540-8553 |
NNS |
denotes |
neurotrophins |
T15069 |
8534-8539 |
JJ |
denotes |
other |
T15070 |
8554-8556 |
CC |
denotes |
or |
T15071 |
8557-8563 |
NN |
denotes |
target |
T15072 |
8564-8571 |
VBN |
denotes |
derived |
T15073 |
8563-8564 |
HYPH |
denotes |
- |
T15074 |
8586-8595 |
NNS |
denotes |
molecules |
T15075 |
8572-8576 |
NN |
denotes |
axon |
T15076 |
8577-8585 |
NN |
denotes |
guidance |
T15077 |
8595-8596 |
. |
denotes |
. |
T15078 |
8596-8731 |
sentence |
denotes |
Furthermore, in vitro, sensory axon response to NT-3 does not appear to be dose-dependent (Ringstedt et al. 1997; Tucker et al. 2001). |
T15079 |
8597-8608 |
RB |
denotes |
Furthermore |
T15080 |
8659-8665 |
VB |
denotes |
appear |
T15081 |
8608-8610 |
, |
denotes |
, |
T15082 |
8610-8612 |
FW |
denotes |
in |
T15083 |
8613-8618 |
FW |
denotes |
vitro |
T15084 |
8618-8620 |
, |
denotes |
, |
T15085 |
8620-8627 |
JJ |
denotes |
sensory |
T15086 |
8628-8632 |
NN |
denotes |
axon |
T15087 |
8633-8641 |
NN |
denotes |
response |
T15088 |
8642-8644 |
IN |
denotes |
to |
T15089 |
8645-8647 |
NN |
denotes |
NT |
T15090 |
8647-8648 |
HYPH |
denotes |
- |
T15091 |
8648-8649 |
CD |
denotes |
3 |
T15092 |
8650-8654 |
VBZ |
denotes |
does |
T15093 |
8655-8658 |
RB |
denotes |
not |
T15094 |
8666-8668 |
TO |
denotes |
to |
T15095 |
8669-8671 |
VB |
denotes |
be |
T15096 |
8672-8676 |
NN |
denotes |
dose |
T15097 |
8677-8686 |
JJ |
denotes |
dependent |
T15098 |
8676-8677 |
HYPH |
denotes |
- |
T15099 |
8687-8688 |
-LRB- |
denotes |
( |
T15100 |
8688-8697 |
NNP |
denotes |
Ringstedt |
T15101 |
8698-8700 |
FW |
denotes |
et |
T15102 |
8701-8704 |
FW |
denotes |
al. |
T15103 |
8705-8709 |
CD |
denotes |
1997 |
T15104 |
8709-8710 |
: |
denotes |
; |
T15105 |
8711-8717 |
NNP |
denotes |
Tucker |
T15106 |
8718-8720 |
FW |
denotes |
et |
T15107 |
8721-8724 |
FW |
denotes |
al. |
T15108 |
8725-8729 |
CD |
denotes |
2001 |
T15109 |
8729-8730 |
-RRB- |
denotes |
) |
T15110 |
8730-8731 |
. |
denotes |
. |
T15111 |
8731-8900 |
sentence |
denotes |
NT-3 is capable of attracting axons along distances of up to 1 mm in collagen gel matrix, covering the physiological range it needs to attract axons during development. |
T15112 |
8732-8734 |
NN |
denotes |
NT |
T15113 |
8737-8739 |
VBZ |
denotes |
is |
T15114 |
8734-8735 |
HYPH |
denotes |
- |
T15115 |
8735-8736 |
CD |
denotes |
3 |
T15116 |
8740-8747 |
JJ |
denotes |
capable |
T15117 |
8748-8750 |
IN |
denotes |
of |
T15118 |
8751-8761 |
VBG |
denotes |
attracting |
T15119 |
8762-8767 |
NNS |
denotes |
axons |
T15120 |
8768-8773 |
IN |
denotes |
along |
T15121 |
8774-8783 |
NNS |
denotes |
distances |
T15122 |
8784-8786 |
IN |
denotes |
of |
T15123 |
8787-8789 |
IN |
denotes |
up |
T15124 |
8793-8794 |
CD |
denotes |
1 |
T15125 |
8790-8792 |
IN |
denotes |
to |
T15126 |
8795-8797 |
NN |
denotes |
mm |
T15127 |
8798-8800 |
IN |
denotes |
in |
T15128 |
8801-8809 |
NN |
denotes |
collagen |
T15129 |
8814-8820 |
NN |
denotes |
matrix |
T15130 |
8810-8813 |
NN |
denotes |
gel |
T15131 |
8820-8822 |
, |
denotes |
, |
T15132 |
8822-8830 |
VBG |
denotes |
covering |
T15133 |
8831-8834 |
DT |
denotes |
the |
T15134 |
8849-8854 |
NN |
denotes |
range |
T15135 |
8835-8848 |
JJ |
denotes |
physiological |
T15136 |
8855-8857 |
PRP |
denotes |
it |
T15137 |
8858-8863 |
VBZ |
denotes |
needs |
T15138 |
8864-8866 |
TO |
denotes |
to |
T15139 |
8867-8874 |
VB |
denotes |
attract |
T15140 |
8875-8880 |
NNS |
denotes |
axons |
T15141 |
8881-8887 |
IN |
denotes |
during |
T15142 |
8888-8899 |
NN |
denotes |
development |
T15143 |
8899-8900 |
. |
denotes |
. |
T15144 |
8900-9151 |
sentence |
denotes |
Previous studies with exogenous or local applications of NT-3 to developing primary sensory axons have indicated that this neurotrophin can attract and induce axonal branching (Ulupınar et al. 2000; Özdinler and Erzurumlu 2001, Özdinler et al. 2004). |
T15145 |
8901-8909 |
JJ |
denotes |
Previous |
T15146 |
8910-8917 |
NNS |
denotes |
studies |
T15147 |
9004-9013 |
VBN |
denotes |
indicated |
T15148 |
8918-8922 |
IN |
denotes |
with |
T15149 |
8923-8932 |
JJ |
denotes |
exogenous |
T15150 |
8942-8954 |
NNS |
denotes |
applications |
T15151 |
8933-8935 |
CC |
denotes |
or |
T15152 |
8936-8941 |
JJ |
denotes |
local |
T15153 |
8955-8957 |
IN |
denotes |
of |
T15154 |
8958-8960 |
NN |
denotes |
NT |
T15155 |
8960-8961 |
HYPH |
denotes |
- |
T15156 |
8961-8962 |
CD |
denotes |
3 |
T15157 |
8963-8965 |
IN |
denotes |
to |
T15158 |
8966-8976 |
JJ |
denotes |
developing |
T15159 |
8993-8998 |
NNS |
denotes |
axons |
T15160 |
8977-8984 |
JJ |
denotes |
primary |
T15161 |
8985-8992 |
JJ |
denotes |
sensory |
T15162 |
8999-9003 |
VBP |
denotes |
have |
T15163 |
9014-9018 |
IN |
denotes |
that |
T15164 |
9041-9048 |
VB |
denotes |
attract |
T15165 |
9019-9023 |
DT |
denotes |
this |
T15166 |
9024-9036 |
NN |
denotes |
neurotrophin |
T15167 |
9037-9040 |
MD |
denotes |
can |
T15168 |
9049-9052 |
CC |
denotes |
and |
T15169 |
9053-9059 |
VB |
denotes |
induce |
T15170 |
9060-9066 |
JJ |
denotes |
axonal |
T15171 |
9067-9076 |
NN |
denotes |
branching |
T15172 |
9077-9078 |
-LRB- |
denotes |
( |
T15173 |
9078-9086 |
NNP |
denotes |
Ulupınar |
T15174 |
9087-9089 |
FW |
denotes |
et |
T15175 |
9090-9093 |
FW |
denotes |
al. |
T15176 |
9094-9098 |
CD |
denotes |
2000 |
T15177 |
9098-9099 |
: |
denotes |
; |
T15178 |
9100-9108 |
NNP |
denotes |
Özdinler |
T15179 |
9109-9112 |
CC |
denotes |
and |
T15180 |
9113-9122 |
NNP |
denotes |
Erzurumlu |
T15181 |
9123-9127 |
CD |
denotes |
2001 |
T15182 |
9127-9129 |
, |
denotes |
, |
T15183 |
9129-9137 |
NNP |
denotes |
Özdinler |
T15184 |
9138-9140 |
FW |
denotes |
et |
T15185 |
9141-9144 |
FW |
denotes |
al. |
T15186 |
9145-9149 |
CD |
denotes |
2004 |
T15187 |
9149-9150 |
-RRB- |
denotes |
) |
T15188 |
9150-9151 |
. |
denotes |
. |
T15189 |
9151-9302 |
sentence |
denotes |
Along the monosynaptic stretch reflex pathway, only Wnt-3 has been implicated as an axon arborization factor in the spinal cord (Krylova et al. 2002). |
T15190 |
9152-9157 |
IN |
denotes |
Along |
T15191 |
9219-9229 |
VBN |
denotes |
implicated |
T15192 |
9158-9161 |
DT |
denotes |
the |
T15193 |
9190-9197 |
NN |
denotes |
pathway |
T15194 |
9162-9174 |
JJ |
denotes |
monosynaptic |
T15195 |
9175-9182 |
NN |
denotes |
stretch |
T15196 |
9183-9189 |
NN |
denotes |
reflex |
T15197 |
9197-9199 |
, |
denotes |
, |
T15198 |
9199-9203 |
RB |
denotes |
only |
T15199 |
9204-9207 |
NN |
denotes |
Wnt |
T15200 |
9207-9208 |
HYPH |
denotes |
- |
T15201 |
9208-9209 |
CD |
denotes |
3 |
T15202 |
9210-9213 |
VBZ |
denotes |
has |
T15203 |
9214-9218 |
VBN |
denotes |
been |
T15204 |
9230-9232 |
IN |
denotes |
as |
T15205 |
9233-9235 |
DT |
denotes |
an |
T15206 |
9254-9260 |
NN |
denotes |
factor |
T15207 |
9236-9240 |
NN |
denotes |
axon |
T15208 |
9241-9253 |
NN |
denotes |
arborization |
T15209 |
9261-9263 |
IN |
denotes |
in |
T15210 |
9264-9267 |
DT |
denotes |
the |
T15211 |
9275-9279 |
NN |
denotes |
cord |
T15212 |
9268-9274 |
JJ |
denotes |
spinal |
T15213 |
9280-9281 |
-LRB- |
denotes |
( |
T15214 |
9281-9288 |
NNP |
denotes |
Krylova |
T15215 |
9289-9291 |
FW |
denotes |
et |
T15216 |
9292-9295 |
FW |
denotes |
al. |
T15217 |
9296-9300 |
CD |
denotes |
2002 |
T15218 |
9300-9301 |
-RRB- |
denotes |
) |
T15219 |
9301-9302 |
. |
denotes |
. |
T15220 |
9302-9494 |
sentence |
denotes |
Another molecule, Slit2, expressed in the midline and by motor neurons (Wang et al. 1999) is capable of inducing axonal branching (Nguyen Ba-Charvet et al. 2001; Özdinler and Erzurumlu 2002). |
T15221 |
9303-9310 |
DT |
denotes |
Another |
T15222 |
9311-9319 |
NN |
denotes |
molecule |
T15223 |
9393-9395 |
VBZ |
denotes |
is |
T15224 |
9319-9321 |
, |
denotes |
, |
T15225 |
9321-9326 |
NN |
denotes |
Slit2 |
T15226 |
9326-9328 |
, |
denotes |
, |
T15227 |
9328-9337 |
VBN |
denotes |
expressed |
T15228 |
9338-9340 |
IN |
denotes |
in |
T15229 |
9341-9344 |
DT |
denotes |
the |
T15230 |
9345-9352 |
NN |
denotes |
midline |
T15231 |
9353-9356 |
CC |
denotes |
and |
T15232 |
9357-9359 |
IN |
denotes |
by |
T15233 |
9360-9365 |
NN |
denotes |
motor |
T15234 |
9366-9373 |
NNS |
denotes |
neurons |
T15235 |
9374-9375 |
-LRB- |
denotes |
( |
T15236 |
9375-9379 |
NNP |
denotes |
Wang |
T15237 |
9380-9382 |
FW |
denotes |
et |
T15238 |
9383-9386 |
FW |
denotes |
al. |
T15239 |
9387-9391 |
CD |
denotes |
1999 |
T15240 |
9391-9392 |
-RRB- |
denotes |
) |
T15241 |
9396-9403 |
JJ |
denotes |
capable |
T15242 |
9404-9406 |
IN |
denotes |
of |
T15243 |
9407-9415 |
VBG |
denotes |
inducing |
T15244 |
9416-9422 |
JJ |
denotes |
axonal |
T15245 |
9423-9432 |
NN |
denotes |
branching |
T15246 |
9433-9434 |
-LRB- |
denotes |
( |
T15247 |
9434-9440 |
NNP |
denotes |
Nguyen |
T15248 |
9441-9443 |
NNP |
denotes |
Ba |
T15249 |
9443-9444 |
HYPH |
denotes |
- |
T15250 |
9444-9451 |
NNP |
denotes |
Charvet |
T15251 |
9452-9454 |
FW |
denotes |
et |
T15252 |
9455-9458 |
FW |
denotes |
al. |
T15253 |
9459-9463 |
CD |
denotes |
2001 |
T15254 |
9463-9464 |
: |
denotes |
; |
T15255 |
9465-9473 |
NNP |
denotes |
Özdinler |
T15256 |
9474-9477 |
CC |
denotes |
and |
T15257 |
9478-9487 |
NNP |
denotes |
Erzurumlu |
T15258 |
9488-9492 |
CD |
denotes |
2002 |
T15259 |
9492-9493 |
-RRB- |
denotes |
) |
T15260 |
9493-9494 |
. |
denotes |
. |
T15261 |
9494-9648 |
sentence |
denotes |
DRG neurons express Robo receptors, which bind to Slits, and proprioceptive axons are therefore capable of responding to Slit signals (Wang et al. 1999). |
T15262 |
9495-9498 |
NN |
denotes |
DRG |
T15263 |
9499-9506 |
NNS |
denotes |
neurons |
T15264 |
9507-9514 |
VBP |
denotes |
express |
T15265 |
9515-9519 |
NN |
denotes |
Robo |
T15266 |
9520-9529 |
NNS |
denotes |
receptors |
T15267 |
9529-9531 |
, |
denotes |
, |
T15268 |
9531-9536 |
WDT |
denotes |
which |
T15269 |
9537-9541 |
VBP |
denotes |
bind |
T15270 |
9542-9544 |
IN |
denotes |
to |
T15271 |
9545-9550 |
NNS |
denotes |
Slits |
T15272 |
9550-9552 |
, |
denotes |
, |
T15273 |
9552-9555 |
CC |
denotes |
and |
T15274 |
9556-9570 |
JJ |
denotes |
proprioceptive |
T15275 |
9571-9576 |
NNS |
denotes |
axons |
T15276 |
9577-9580 |
VBP |
denotes |
are |
T15277 |
9581-9590 |
RB |
denotes |
therefore |
T15278 |
9591-9598 |
JJ |
denotes |
capable |
T15279 |
9599-9601 |
IN |
denotes |
of |
T15280 |
9602-9612 |
VBG |
denotes |
responding |
T15281 |
9613-9615 |
IN |
denotes |
to |
T15282 |
9616-9620 |
NN |
denotes |
Slit |
T15283 |
9621-9628 |
NNS |
denotes |
signals |
T15284 |
9629-9630 |
-LRB- |
denotes |
( |
T15285 |
9630-9634 |
NNP |
denotes |
Wang |
T15286 |
9635-9637 |
FW |
denotes |
et |
T15287 |
9638-9641 |
FW |
denotes |
al. |
T15288 |
9642-9646 |
CD |
denotes |
1999 |
T15289 |
9646-9647 |
-RRB- |
denotes |
) |
T15290 |
9647-9648 |
. |
denotes |
. |
T15291 |
9648-9864 |
sentence |
denotes |
Slit2 does not cause repulsion of NT-3-responsive DRG axons in vitro (Nguyen Ba-Charvet et al. 2001), but causes ectopic branching and arborization of trigeminal axons in the brainstem (Özdinler and Erzurumlu 2002). |
T15292 |
9649-9654 |
NN |
denotes |
Slit2 |
T15293 |
9664-9669 |
VB |
denotes |
cause |
T15294 |
9655-9659 |
VBZ |
denotes |
does |
T15295 |
9660-9663 |
RB |
denotes |
not |
T15296 |
9670-9679 |
NN |
denotes |
repulsion |
T15297 |
9680-9682 |
IN |
denotes |
of |
T15298 |
9683-9685 |
NN |
denotes |
NT |
T15299 |
9688-9698 |
JJ |
denotes |
responsive |
T15300 |
9685-9686 |
HYPH |
denotes |
- |
T15301 |
9686-9687 |
CD |
denotes |
3 |
T15302 |
9687-9688 |
HYPH |
denotes |
- |
T15303 |
9703-9708 |
NNS |
denotes |
axons |
T15304 |
9699-9702 |
NN |
denotes |
DRG |
T15305 |
9709-9711 |
FW |
denotes |
in |
T15306 |
9712-9717 |
FW |
denotes |
vitro |
T15307 |
9718-9719 |
-LRB- |
denotes |
( |
T15308 |
9719-9725 |
NNP |
denotes |
Nguyen |
T15309 |
9726-9728 |
NNP |
denotes |
Ba |
T15310 |
9728-9729 |
HYPH |
denotes |
- |
T15311 |
9729-9736 |
NNP |
denotes |
Charvet |
T15312 |
9737-9739 |
FW |
denotes |
et |
T15313 |
9740-9743 |
FW |
denotes |
al. |
T15314 |
9744-9748 |
CD |
denotes |
2001 |
T15315 |
9748-9749 |
-RRB- |
denotes |
) |
T15316 |
9749-9751 |
, |
denotes |
, |
T15317 |
9751-9754 |
CC |
denotes |
but |
T15318 |
9755-9761 |
VBZ |
denotes |
causes |
T15319 |
9762-9769 |
JJ |
denotes |
ectopic |
T15320 |
9770-9779 |
NN |
denotes |
branching |
T15321 |
9780-9783 |
CC |
denotes |
and |
T15322 |
9784-9796 |
NN |
denotes |
arborization |
T15323 |
9797-9799 |
IN |
denotes |
of |
T15324 |
9800-9810 |
JJ |
denotes |
trigeminal |
T15325 |
9811-9816 |
NNS |
denotes |
axons |
T15326 |
9817-9819 |
IN |
denotes |
in |
T15327 |
9820-9823 |
DT |
denotes |
the |
T15328 |
9824-9833 |
NN |
denotes |
brainstem |
T15329 |
9834-9835 |
-LRB- |
denotes |
( |
T15330 |
9835-9843 |
NNP |
denotes |
Özdinler |
T15331 |
9844-9847 |
CC |
denotes |
and |
T15332 |
9848-9857 |
NNP |
denotes |
Erzurumlu |
T15333 |
9858-9862 |
CD |
denotes |
2002 |
T15334 |
9862-9863 |
-RRB- |
denotes |
) |
T15335 |
9863-9864 |
. |
denotes |
. |
T15336 |
9864-10021 |
sentence |
denotes |
Thus, Slit2 might also be involved in terminal branching of propioceptive axons in the ventral cord and in the midline branching observed in our double KOs. |
T15337 |
9865-9869 |
RB |
denotes |
Thus |
T15338 |
9891-9899 |
VBN |
denotes |
involved |
T15339 |
9869-9871 |
, |
denotes |
, |
T15340 |
9871-9876 |
NN |
denotes |
Slit2 |
T15341 |
9877-9882 |
MD |
denotes |
might |
T15342 |
9883-9887 |
RB |
denotes |
also |
T15343 |
9888-9890 |
VB |
denotes |
be |
T15344 |
9900-9902 |
IN |
denotes |
in |
T15345 |
9903-9911 |
JJ |
denotes |
terminal |
T15346 |
9912-9921 |
NN |
denotes |
branching |
T15347 |
9922-9924 |
IN |
denotes |
of |
T15348 |
9925-9938 |
JJ |
denotes |
propioceptive |
T15349 |
9939-9944 |
NNS |
denotes |
axons |
T15350 |
9945-9947 |
IN |
denotes |
in |
T15351 |
9948-9951 |
DT |
denotes |
the |
T15352 |
9960-9964 |
NN |
denotes |
cord |
T15353 |
9952-9959 |
JJ |
denotes |
ventral |
T15354 |
9965-9968 |
CC |
denotes |
and |
T15355 |
9969-9971 |
IN |
denotes |
in |
T15356 |
9972-9975 |
DT |
denotes |
the |
T15357 |
9984-9993 |
NN |
denotes |
branching |
T15358 |
9976-9983 |
NN |
denotes |
midline |
T15359 |
9994-10002 |
VBN |
denotes |
observed |
T15360 |
10003-10005 |
IN |
denotes |
in |
T15361 |
10006-10009 |
PRP$ |
denotes |
our |
T15362 |
10017-10020 |
NNS |
denotes |
KOs |
T15363 |
10010-10016 |
JJ |
denotes |
double |
T15364 |
10020-10021 |
. |
denotes |
. |
T15365 |
10021-10174 |
sentence |
denotes |
Lack of PV expression in Bax/NT-3 KO mice suggests that PV expression might be responsible for proper axon targeting and muscle spindle differentiation. |
T15366 |
10022-10026 |
NN |
denotes |
Lack |
T15367 |
10064-10072 |
VBZ |
denotes |
suggests |
T15368 |
10027-10029 |
IN |
denotes |
of |
T15369 |
10030-10032 |
NN |
denotes |
PV |
T15370 |
10033-10043 |
NN |
denotes |
expression |
T15371 |
10044-10046 |
IN |
denotes |
in |
T15372 |
10047-10050 |
NN |
denotes |
Bax |
T15373 |
10056-10058 |
NN |
denotes |
KO |
T15374 |
10050-10051 |
HYPH |
denotes |
/ |
T15375 |
10051-10053 |
NN |
denotes |
NT |
T15376 |
10053-10054 |
HYPH |
denotes |
- |
T15377 |
10054-10055 |
CD |
denotes |
3 |
T15378 |
10059-10063 |
NNS |
denotes |
mice |
T15379 |
10073-10077 |
IN |
denotes |
that |
T15380 |
10098-10100 |
VB |
denotes |
be |
T15381 |
10078-10080 |
NN |
denotes |
PV |
T15382 |
10081-10091 |
NN |
denotes |
expression |
T15383 |
10092-10097 |
MD |
denotes |
might |
T15384 |
10101-10112 |
JJ |
denotes |
responsible |
T15385 |
10113-10116 |
IN |
denotes |
for |
T15386 |
10117-10123 |
JJ |
denotes |
proper |
T15387 |
10129-10138 |
NN |
denotes |
targeting |
T15388 |
10124-10128 |
NN |
denotes |
axon |
T15389 |
10139-10142 |
CC |
denotes |
and |
T15390 |
10143-10149 |
NN |
denotes |
muscle |
T15391 |
10150-10157 |
NN |
denotes |
spindle |
T15392 |
10158-10173 |
NN |
denotes |
differentiation |
T15393 |
10173-10174 |
. |
denotes |
. |
T15394 |
10174-10232 |
sentence |
denotes |
Presently we cannot completely rule out this possibility. |
T15395 |
10175-10184 |
RB |
denotes |
Presently |
T15396 |
10206-10210 |
VB |
denotes |
rule |
T15397 |
10185-10187 |
PRP |
denotes |
we |
T15398 |
10188-10191 |
MD |
denotes |
can |
T15399 |
10191-10194 |
RB |
denotes |
not |
T15400 |
10195-10205 |
RB |
denotes |
completely |
T15401 |
10211-10214 |
RP |
denotes |
out |
T15402 |
10215-10219 |
DT |
denotes |
this |
T15403 |
10220-10231 |
NN |
denotes |
possibility |
T15404 |
10231-10232 |
. |
denotes |
. |
T15405 |
10232-10490 |
sentence |
denotes |
However, no defects in axon pathfinding along the monosynaptic reflex arc or in muscle spindle differentiation have been noted in PV KO mice, which develop normally and show no apparent changes in their behavior or physical activity (Schwaller et al. 1999). |
T15406 |
10233-10240 |
RB |
denotes |
However |
T15407 |
10354-10359 |
VBN |
denotes |
noted |
T15408 |
10240-10242 |
, |
denotes |
, |
T15409 |
10242-10244 |
DT |
denotes |
no |
T15410 |
10245-10252 |
NNS |
denotes |
defects |
T15411 |
10253-10255 |
IN |
denotes |
in |
T15412 |
10256-10260 |
NN |
denotes |
axon |
T15413 |
10261-10272 |
NN |
denotes |
pathfinding |
T15414 |
10273-10278 |
IN |
denotes |
along |
T15415 |
10279-10282 |
DT |
denotes |
the |
T15416 |
10303-10306 |
NN |
denotes |
arc |
T15417 |
10283-10295 |
JJ |
denotes |
monosynaptic |
T15418 |
10296-10302 |
NN |
denotes |
reflex |
T15419 |
10307-10309 |
CC |
denotes |
or |
T15420 |
10310-10312 |
IN |
denotes |
in |
T15421 |
10313-10319 |
NN |
denotes |
muscle |
T15422 |
10320-10327 |
NN |
denotes |
spindle |
T15423 |
10328-10343 |
NN |
denotes |
differentiation |
T15424 |
10344-10348 |
VBP |
denotes |
have |
T15425 |
10349-10353 |
VBN |
denotes |
been |
T15426 |
10360-10362 |
IN |
denotes |
in |
T15427 |
10363-10365 |
NN |
denotes |
PV |
T15428 |
10366-10368 |
NN |
denotes |
KO |
T15429 |
10369-10373 |
NNS |
denotes |
mice |
T15430 |
10373-10375 |
, |
denotes |
, |
T15431 |
10375-10380 |
WDT |
denotes |
which |
T15432 |
10381-10388 |
VBP |
denotes |
develop |
T15433 |
10389-10397 |
RB |
denotes |
normally |
T15434 |
10398-10401 |
CC |
denotes |
and |
T15435 |
10402-10406 |
VBP |
denotes |
show |
T15436 |
10407-10409 |
DT |
denotes |
no |
T15437 |
10419-10426 |
NNS |
denotes |
changes |
T15438 |
10410-10418 |
JJ |
denotes |
apparent |
T15439 |
10427-10429 |
IN |
denotes |
in |
T15440 |
10430-10435 |
PRP$ |
denotes |
their |
T15441 |
10436-10444 |
NN |
denotes |
behavior |
T15442 |
10445-10447 |
CC |
denotes |
or |
T15443 |
10448-10456 |
JJ |
denotes |
physical |
T15444 |
10457-10465 |
NN |
denotes |
activity |
T15445 |
10466-10467 |
-LRB- |
denotes |
( |
T15446 |
10467-10476 |
NNP |
denotes |
Schwaller |
T15447 |
10477-10479 |
FW |
denotes |
et |
T15448 |
10480-10483 |
FW |
denotes |
al. |
T15449 |
10484-10488 |
CD |
denotes |
1999 |
T15450 |
10488-10489 |
-RRB- |
denotes |
) |
T15451 |
10489-10490 |
. |
denotes |
. |
T15452 |
10490-10645 |
sentence |
denotes |
These observations suggest that axonal targeting defects in Bax/NT-3 double KO mice cannot be simply due to lack of PV expression in proprioceptive cells. |
T15453 |
10491-10496 |
DT |
denotes |
These |
T15454 |
10497-10509 |
NNS |
denotes |
observations |
T15455 |
10510-10517 |
VBP |
denotes |
suggest |
T15456 |
10518-10522 |
IN |
denotes |
that |
T15457 |
10582-10584 |
VB |
denotes |
be |
T15458 |
10523-10529 |
JJ |
denotes |
axonal |
T15459 |
10540-10547 |
NNS |
denotes |
defects |
T15460 |
10530-10539 |
VBG |
denotes |
targeting |
T15461 |
10548-10550 |
IN |
denotes |
in |
T15462 |
10551-10554 |
NN |
denotes |
Bax |
T15463 |
10567-10569 |
NN |
denotes |
KO |
T15464 |
10554-10555 |
HYPH |
denotes |
/ |
T15465 |
10555-10557 |
NN |
denotes |
NT |
T15466 |
10557-10558 |
HYPH |
denotes |
- |
T15467 |
10558-10559 |
CD |
denotes |
3 |
T15468 |
10560-10566 |
JJ |
denotes |
double |
T15469 |
10570-10574 |
NNS |
denotes |
mice |
T15470 |
10575-10578 |
MD |
denotes |
can |
T15471 |
10578-10581 |
RB |
denotes |
not |
T15472 |
10585-10591 |
RB |
denotes |
simply |
T15473 |
10592-10595 |
IN |
denotes |
due |
T15474 |
10596-10598 |
IN |
denotes |
to |
T15475 |
10599-10603 |
NN |
denotes |
lack |
T15476 |
10604-10606 |
IN |
denotes |
of |
T15477 |
10607-10609 |
NN |
denotes |
PV |
T15478 |
10610-10620 |
NN |
denotes |
expression |
T15479 |
10621-10623 |
IN |
denotes |
in |
T15480 |
10624-10638 |
JJ |
denotes |
proprioceptive |
T15481 |
10639-10644 |
NNS |
denotes |
cells |
T15482 |
10644-10645 |
. |
denotes |
. |
T15483 |
10645-10842 |
sentence |
denotes |
Our present results suggest that NT-3 acts as a short-range axon guidance cue for proprioceptive axons centrally and peripherally, as they navigate to their targets using other axon guidance cues. |
T15484 |
10646-10649 |
PRP$ |
denotes |
Our |
T15485 |
10658-10665 |
NNS |
denotes |
results |
T15486 |
10650-10657 |
JJ |
denotes |
present |
T15487 |
10666-10673 |
VBP |
denotes |
suggest |
T15488 |
10674-10678 |
IN |
denotes |
that |
T15489 |
10684-10688 |
VBZ |
denotes |
acts |
T15490 |
10679-10681 |
NN |
denotes |
NT |
T15491 |
10681-10682 |
HYPH |
denotes |
- |
T15492 |
10682-10683 |
CD |
denotes |
3 |
T15493 |
10689-10691 |
IN |
denotes |
as |
T15494 |
10692-10693 |
DT |
denotes |
a |
T15495 |
10720-10723 |
NN |
denotes |
cue |
T15496 |
10694-10699 |
JJ |
denotes |
short |
T15497 |
10700-10705 |
NN |
denotes |
range |
T15498 |
10699-10700 |
HYPH |
denotes |
- |
T15499 |
10706-10710 |
NN |
denotes |
axon |
T15500 |
10711-10719 |
NN |
denotes |
guidance |
T15501 |
10724-10727 |
IN |
denotes |
for |
T15502 |
10728-10742 |
JJ |
denotes |
proprioceptive |
T15503 |
10743-10748 |
NNS |
denotes |
axons |
T15504 |
10749-10758 |
RB |
denotes |
centrally |
T15505 |
10759-10762 |
CC |
denotes |
and |
T15506 |
10763-10775 |
RB |
denotes |
peripherally |
T15507 |
10775-10777 |
, |
denotes |
, |
T15508 |
10777-10779 |
IN |
denotes |
as |
T15509 |
10785-10793 |
VBP |
denotes |
navigate |
T15510 |
10780-10784 |
PRP |
denotes |
they |
T15511 |
10794-10796 |
IN |
denotes |
to |
T15512 |
10797-10802 |
PRP$ |
denotes |
their |
T15513 |
10803-10810 |
NNS |
denotes |
targets |
T15514 |
10811-10816 |
VBG |
denotes |
using |
T15515 |
10817-10822 |
JJ |
denotes |
other |
T15516 |
10837-10841 |
NNS |
denotes |
cues |
T15517 |
10823-10827 |
NN |
denotes |
axon |
T15518 |
10828-10836 |
NN |
denotes |
guidance |
T15519 |
10841-10842 |
. |
denotes |
. |
T15520 |
10842-10903 |
sentence |
denotes |
In its absence, these axons terminate in inappropriate loci. |
T15521 |
10843-10845 |
IN |
denotes |
In |
T15522 |
10871-10880 |
VBP |
denotes |
terminate |
T15523 |
10846-10849 |
PRP$ |
denotes |
its |
T15524 |
10850-10857 |
NN |
denotes |
absence |
T15525 |
10857-10859 |
, |
denotes |
, |
T15526 |
10859-10864 |
DT |
denotes |
these |
T15527 |
10865-10870 |
NNS |
denotes |
axons |
T15528 |
10881-10883 |
IN |
denotes |
in |
T15529 |
10884-10897 |
JJ |
denotes |
inappropriate |
T15530 |
10898-10902 |
NNS |
denotes |
loci |
T15531 |
10902-10903 |
. |
denotes |
. |
T15532 |
10903-11045 |
sentence |
denotes |
However, NT-3 may not be the only molecule that plays a role in targeting and terminal branching of sensory axons in the ventral spinal cord. |
T15533 |
10904-10911 |
RB |
denotes |
However |
T15534 |
10926-10928 |
VB |
denotes |
be |
T15535 |
10911-10913 |
, |
denotes |
, |
T15536 |
10913-10915 |
NN |
denotes |
NT |
T15537 |
10915-10916 |
HYPH |
denotes |
- |
T15538 |
10916-10917 |
CD |
denotes |
3 |
T15539 |
10918-10921 |
MD |
denotes |
may |
T15540 |
10922-10925 |
RB |
denotes |
not |
T15541 |
10929-10932 |
DT |
denotes |
the |
T15542 |
10938-10946 |
NN |
denotes |
molecule |
T15543 |
10933-10937 |
JJ |
denotes |
only |
T15544 |
10947-10951 |
WDT |
denotes |
that |
T15545 |
10952-10957 |
VBZ |
denotes |
plays |
T15546 |
10958-10959 |
DT |
denotes |
a |
T15547 |
10960-10964 |
NN |
denotes |
role |
T15548 |
10965-10967 |
IN |
denotes |
in |
T15549 |
10968-10977 |
VBG |
denotes |
targeting |
T15550 |
10978-10981 |
CC |
denotes |
and |
T15551 |
10982-10990 |
JJ |
denotes |
terminal |
T15552 |
10991-11000 |
NN |
denotes |
branching |
T15553 |
11001-11003 |
IN |
denotes |
of |
T15554 |
11004-11011 |
JJ |
denotes |
sensory |
T15555 |
11012-11017 |
NNS |
denotes |
axons |
T15556 |
11018-11020 |
IN |
denotes |
in |
T15557 |
11021-11024 |
DT |
denotes |
the |
T15558 |
11040-11044 |
NN |
denotes |
cord |
T15559 |
11025-11032 |
JJ |
denotes |
ventral |
T15560 |
11033-11039 |
JJ |
denotes |
spinal |
T15561 |
11044-11045 |
. |
denotes |
. |
T15562 |
11045-11250 |
sentence |
denotes |
NT-3 most likely acts cooperatively with other axon guidance molecules or by regulating expression of yet to be identified proprioceptive neuron-specific receptors/ligands for numerous axon guidance cues. |
T15563 |
11046-11048 |
NN |
denotes |
NT |
T15564 |
11063-11067 |
VBZ |
denotes |
acts |
T15565 |
11048-11049 |
HYPH |
denotes |
- |
T15566 |
11049-11050 |
CD |
denotes |
3 |
T15567 |
11051-11055 |
RBS |
denotes |
most |
T15568 |
11056-11062 |
RB |
denotes |
likely |
T15569 |
11068-11081 |
RB |
denotes |
cooperatively |
T15570 |
11082-11086 |
IN |
denotes |
with |
T15571 |
11087-11092 |
JJ |
denotes |
other |
T15572 |
11107-11116 |
NNS |
denotes |
molecules |
T15573 |
11093-11097 |
NN |
denotes |
axon |
T15574 |
11098-11106 |
NN |
denotes |
guidance |
T15575 |
11117-11119 |
CC |
denotes |
or |
T15576 |
11120-11122 |
IN |
denotes |
by |
T15577 |
11123-11133 |
VBG |
denotes |
regulating |
T15578 |
11134-11144 |
NN |
denotes |
expression |
T15579 |
11145-11147 |
IN |
denotes |
of |
T15580 |
11148-11151 |
RB |
denotes |
yet |
T15581 |
11158-11168 |
VBN |
denotes |
identified |
T15582 |
11152-11154 |
TO |
denotes |
to |
T15583 |
11155-11157 |
VB |
denotes |
be |
T13995 |
3223-3226 |
CC |
denotes |
and |
T15584 |
11169-11183 |
JJ |
denotes |
proprioceptive |
T15585 |
11184-11190 |
NN |
denotes |
neuron |
T15586 |
11191-11199 |
JJ |
denotes |
specific |
T15587 |
11190-11191 |
HYPH |
denotes |
- |
T15588 |
11200-11209 |
NNS |
denotes |
receptors |
T15589 |
11210-11217 |
NNS |
denotes |
ligands |
T15590 |
11209-11210 |
HYPH |
denotes |
/ |
T15591 |
11218-11221 |
IN |
denotes |
for |
T15592 |
11222-11230 |
JJ |
denotes |
numerous |
T15593 |
11245-11249 |
NNS |
denotes |
cues |
T15594 |
11231-11235 |
NN |
denotes |
axon |
T15595 |
11236-11244 |
NN |
denotes |
guidance |
T15596 |
11249-11250 |
. |
denotes |
. |
R2541 |
T13466 |
T13463 |
pobj |
cultures,in |
R2542 |
T13384 |
T13385 |
advmod |
Relatively,studies |
R2543 |
T13385 |
T13387 |
nsubj |
studies,implicated |
R2544 |
T13386 |
T13385 |
amod |
few,studies |
R2545 |
T13388 |
T13387 |
aux |
have,implicated |
R2546 |
T13389 |
T13387 |
dobj |
NT,implicated |
R2547 |
T13390 |
T13389 |
punct |
-,NT |
R2548 |
T13391 |
T13389 |
nummod |
3,NT |
R2549 |
T13392 |
T13387 |
prep |
as,implicated |
R2550 |
T13393 |
T13394 |
det |
a,agent |
R2551 |
T13394 |
T13392 |
pobj |
agent,as |
R2552 |
T13395 |
T13394 |
amod |
chemoattractant,agent |
R2553 |
T13396 |
T13394 |
prep |
for,agent |
R2554 |
T13397 |
T13398 |
amod |
sensory,axons |
R2555 |
T13398 |
T13396 |
pobj |
axons,for |
R2556 |
T13399 |
T13397 |
cc |
and,sensory |
R2557 |
T13400 |
T13397 |
conj |
motor,sensory |
R2558 |
T13401 |
T13387 |
punct |
.,implicated |
R2559 |
T13467 |
T13457 |
advmod |
preferentially,grow |
R2560 |
T13403 |
T13404 |
advmod |
Previously,noted |
R2561 |
T13404 |
T13405 |
amod |
noted,action |
R2562 |
T13468 |
T13457 |
prep |
towards,grow |
R2563 |
T13405 |
T13407 |
nsubjpass |
action,attributed |
R2564 |
T13406 |
T13405 |
compound |
chemoattractant,action |
R2565 |
T13408 |
T13405 |
prep |
of,action |
R2566 |
T13469 |
T13470 |
npadvmod |
neurotrophin,soaked |
R2567 |
T13409 |
T13410 |
det |
the,process |
R2568 |
T13410 |
T13408 |
pobj |
process,of |
R2569 |
T13411 |
T13412 |
amod |
embryonic,mouse |
R2570 |
T13470 |
T13472 |
amod |
soaked,beads |
R2571 |
T13412 |
T13410 |
nmod |
mouse,process |
R2572 |
T13413 |
T13410 |
amod |
maxillary,process |
R2573 |
T13471 |
T13470 |
punct |
-,soaked |
R2574 |
T13414 |
T13410 |
prep |
on,process |
R2575 |
T13415 |
T13416 |
amod |
trigeminal,neurons |
R2576 |
T13416 |
T13414 |
pobj |
neurons,on |
R2577 |
T13417 |
T13416 |
compound |
ganglion,neurons |
R2578 |
T13472 |
T13468 |
pobj |
beads,towards |
R2579 |
T13418 |
T13419 |
punct |
(,Lumsden |
R2580 |
T13419 |
T13405 |
meta |
Lumsden,action |
R2581 |
T13420 |
T13419 |
cc |
and,Lumsden |
R2582 |
T13473 |
T13474 |
advmod |
instead,of |
R2583 |
T13421 |
T13419 |
conj |
Davies,Lumsden |
R2584 |
T13422 |
T13421 |
nummod |
1986,Davies |
R2585 |
T13423 |
T13421 |
punct |
),Davies |
R2586 |
T13424 |
T13407 |
auxpass |
is,attributed |
R2587 |
T13425 |
T13407 |
advmod |
now,attributed |
R2588 |
T13426 |
T13407 |
prep |
to,attributed |
R2589 |
T13427 |
T13426 |
pobj |
NT,to |
R2590 |
T13474 |
T13457 |
prep |
of,grow |
R2591 |
T13428 |
T13427 |
punct |
-,NT |
R2592 |
T13429 |
T13427 |
nummod |
3,NT |
R2593 |
T13475 |
T13474 |
pcomp |
following,of |
R2594 |
T13430 |
T13427 |
cc |
and,NT |
R2595 |
T13431 |
T13432 |
npadvmod |
brain,derived |
R2596 |
T13476 |
T13477 |
poss |
their,trajectories |
R2597 |
T13432 |
T13434 |
amod |
derived,factor |
R2598 |
T13433 |
T13432 |
punct |
-,derived |
R2599 |
T13434 |
T13427 |
conj |
factor,NT |
R2600 |
T13477 |
T13475 |
dobj |
trajectories,following |
R2601 |
T13435 |
T13434 |
amod |
neurotrophic,factor |
R2602 |
T13436 |
T13434 |
punct |
(,factor |
R2603 |
T13478 |
T13477 |
amod |
normal,trajectories |
R2604 |
T13437 |
T13434 |
appos |
BDNF,factor |
R2605 |
T13438 |
T13407 |
punct |
),attributed |
R2606 |
T13439 |
T13440 |
punct |
(,O'Connor |
R2607 |
T13440 |
T13407 |
meta |
O'Connor,attributed |
R2608 |
T13441 |
T13440 |
nmod |
et,O'Connor |
R2609 |
T13479 |
T13448 |
punct |
.,showed |
R2610 |
T13442 |
T13440 |
nmod |
al.,O'Connor |
R2611 |
T13443 |
T13440 |
nummod |
1999,O'Connor |
R2612 |
T13444 |
T13440 |
punct |
),O'Connor |
R2613 |
T13481 |
T13482 |
advmod |
Conversely,led |
R2614 |
T13445 |
T13407 |
punct |
.,attributed |
R2615 |
T13447 |
T13448 |
advmod |
Recently,showed |
R2616 |
T13483 |
T13482 |
punct |
", ",led |
R2617 |
T13449 |
T13448 |
punct |
", ",showed |
R2618 |
T13450 |
T13448 |
nsubj |
Tucker,showed |
R2619 |
T13451 |
T13452 |
advmod |
et,al. |
R2620 |
T13484 |
T13482 |
nsubj |
beads,led |
R2621 |
T13452 |
T13450 |
advmod |
al.,Tucker |
R2622 |
T13453 |
T13450 |
punct |
(,Tucker |
R2623 |
T13454 |
T13450 |
npadvmod |
2001,Tucker |
R2624 |
T13485 |
T13484 |
acl |
soaked,beads |
R2625 |
T13455 |
T13450 |
punct |
),Tucker |
R2626 |
T13456 |
T13457 |
mark |
that,grow |
R2627 |
T13457 |
T13448 |
ccomp |
grow,showed |
R2628 |
T13458 |
T13459 |
amod |
developing,axons |
R2629 |
T13486 |
T13485 |
prep |
with,soaked |
R2630 |
T13459 |
T13457 |
nsubj |
axons,grow |
R2631 |
T13460 |
T13459 |
amod |
sensory,axons |
R2632 |
T13461 |
T13460 |
cc |
and,sensory |
R2633 |
T13487 |
T13488 |
nmod |
neurotrophin,antibodies |
R2634 |
T13462 |
T13460 |
conj |
motor,sensory |
R2635 |
T13463 |
T13459 |
prep |
in,axons |
R2636 |
T13464 |
T13465 |
compound |
limb,slice |
R2637 |
T13465 |
T13466 |
compound |
slice,cultures |
R2638 |
T13488 |
T13486 |
pobj |
antibodies,with |
R2639 |
T13489 |
T13490 |
npadvmod |
function,blocking |
R2640 |
T13490 |
T13488 |
amod |
blocking,antibodies |
R2641 |
T13572 |
T13571 |
compound |
chemoattractant,role |
R2642 |
T13573 |
T13565 |
prep |
during,play |
R2643 |
T13491 |
T13490 |
punct |
-,blocking |
R2644 |
T13574 |
T13575 |
det |
the,innervation |
R2645 |
T13575 |
T13573 |
pobj |
innervation,during |
R2646 |
T13492 |
T13482 |
prep |
to,led |
R2647 |
T13576 |
T13575 |
prep |
of,innervation |
R2648 |
T13577 |
T13578 |
amod |
ventral,horns |
R2649 |
T13578 |
T13576 |
pobj |
horns,of |
R2650 |
T13493 |
T13492 |
pobj |
reduction,to |
R2651 |
T13579 |
T13575 |
prep |
by,innervation |
R2652 |
T13580 |
T13581 |
amod |
proprioceptive,afferents |
R2653 |
T13494 |
T13493 |
prep |
of,reduction |
R2654 |
T13581 |
T13579 |
pobj |
afferents,by |
R2655 |
T13582 |
T13559 |
punct |
.,considered |
R2656 |
T13495 |
T13496 |
amod |
sensory,growth |
R2657 |
T13584 |
T13585 |
advmod |
However,led |
R2658 |
T13586 |
T13585 |
punct |
", ",led |
R2659 |
T13496 |
T13494 |
pobj |
growth,of |
R2660 |
T13587 |
T13588 |
amod |
earlier,findings |
R2661 |
T13588 |
T13585 |
nsubj |
findings,led |
R2662 |
T13497 |
T13495 |
cc |
and,sensory |
R2663 |
T13589 |
T13588 |
prep |
of,findings |
R2664 |
T13590 |
T13591 |
amod |
normal,trajectories |
R2665 |
T13498 |
T13495 |
conj |
motor,sensory |
R2666 |
T13591 |
T13589 |
pobj |
trajectories,of |
R2667 |
T13499 |
T13496 |
compound |
axon,growth |
R2668 |
T13592 |
T13591 |
amod |
proprioceptive,trajectories |
R2669 |
T13593 |
T13591 |
amod |
afferent,trajectories |
R2670 |
T13594 |
T13591 |
prep |
in,trajectories |
R2671 |
T13500 |
T13496 |
prep |
towards,growth |
R2672 |
T13595 |
T13596 |
compound |
chicken,embryos |
R2673 |
T13596 |
T13594 |
pobj |
embryos,in |
R2674 |
T13501 |
T13502 |
det |
the,limb |
R2675 |
T13597 |
T13588 |
prep |
despite,findings |
R2676 |
T13598 |
T13597 |
pobj |
injection,despite |
R2677 |
T13599 |
T13598 |
prep |
of,injection |
R2678 |
T13502 |
T13500 |
pobj |
limb,towards |
R2679 |
T13600 |
T13601 |
npadvmod |
function,blocking |
R2680 |
T13601 |
T13603 |
amod |
blocking,antibody |
R2681 |
T13503 |
T13482 |
punct |
.,led |
R2682 |
T13602 |
T13601 |
punct |
-,blocking |
R2683 |
T13505 |
T13506 |
prep |
In,altered |
R2684 |
T13603 |
T13599 |
pobj |
antibody,of |
R2685 |
T13604 |
T13603 |
nmod |
NT,antibody |
R2686 |
T13605 |
T13604 |
punct |
-,NT |
R2687 |
T13606 |
T13604 |
nummod |
3,NT |
R2688 |
T13607 |
T13598 |
prep |
into,injection |
R2689 |
T13608 |
T13609 |
det |
the,cord |
R2690 |
T13609 |
T13607 |
pobj |
cord,into |
R2691 |
T13610 |
T13609 |
amod |
spinal,cord |
R2692 |
T13611 |
T13612 |
punct |
(,Oakley |
R2693 |
T13612 |
T13588 |
meta |
Oakley,findings |
R2694 |
T13507 |
T13508 |
amod |
transgenic,mice |
R2695 |
T13613 |
T13612 |
nmod |
et,Oakley |
R2696 |
T13614 |
T13612 |
nmod |
al.,Oakley |
R2697 |
T13615 |
T13612 |
nummod |
1995,Oakley |
R2698 |
T13616 |
T13612 |
punct |
),Oakley |
R2699 |
T13617 |
T13585 |
dobj |
them,led |
R2700 |
T13508 |
T13505 |
pobj |
mice,In |
R2701 |
T13618 |
T13619 |
aux |
to,discount |
R2702 |
T13619 |
T13585 |
xcomp |
discount,led |
R2703 |
T13620 |
T13621 |
det |
this,possibility |
R2704 |
T13621 |
T13619 |
dobj |
possibility,discount |
R2705 |
T13509 |
T13508 |
punct |
", ",mice |
R2706 |
T13622 |
T13585 |
punct |
.,led |
R2707 |
T13624 |
T13625 |
prep |
In,showed |
R2708 |
T13510 |
T13511 |
dep |
which,over-express |
R2709 |
T13626 |
T13627 |
det |
that,study |
R2710 |
T13511 |
T13508 |
relcl |
over-express,mice |
R2711 |
T13627 |
T13624 |
pobj |
study,In |
R2712 |
T13628 |
T13625 |
punct |
", ",showed |
R2713 |
T13629 |
T13625 |
advmod |
though,showed |
R2714 |
T13512 |
T13511 |
dobj |
NT,over-express |
R2715 |
T13630 |
T13625 |
punct |
", ",showed |
R2716 |
T13631 |
T13625 |
nsubj |
assays,showed |
R2717 |
T13632 |
T13631 |
prep |
on,assays |
R2718 |
T13513 |
T13512 |
punct |
-,NT |
R2719 |
T13633 |
T13634 |
det |
the,effectiveness |
R2720 |
T13634 |
T13632 |
pobj |
effectiveness,on |
R2721 |
T13514 |
T13512 |
nummod |
3,NT |
R2722 |
T13635 |
T13634 |
prep |
of,effectiveness |
R2723 |
T13636 |
T13637 |
compound |
antibody,perturbation |
R2724 |
T13637 |
T13635 |
pobj |
perturbation,of |
R2725 |
T13638 |
T13634 |
prep |
on,effectiveness |
R2726 |
T13515 |
T13511 |
prep |
under,over-express |
R2727 |
T13639 |
T13640 |
npadvmod |
NT,dependent |
R2728 |
T13640 |
T13644 |
amod |
dependent,survival |
R2729 |
T13516 |
T13517 |
det |
the,promoter |
R2730 |
T13641 |
T13639 |
punct |
-,NT |
R2731 |
T13642 |
T13639 |
nummod |
3,NT |
R2732 |
T13643 |
T13640 |
punct |
-,dependent |
R2733 |
T13517 |
T13515 |
pobj |
promoter,under |
R2734 |
T13644 |
T13638 |
pobj |
survival,on |
R2735 |
T13645 |
T13644 |
compound |
cell,survival |
R2736 |
T13646 |
T13647 |
mark |
that,was |
R2737 |
T13518 |
T13517 |
compound |
nestin,promoter |
R2738 |
T13647 |
T13625 |
ccomp |
was,showed |
R2739 |
T13648 |
T13647 |
nsubj |
effectiveness,was |
R2740 |
T13649 |
T13647 |
acomp |
significant,was |
R2741 |
T13650 |
T13651 |
punct |
(,% |
R2742 |
T13651 |
T13649 |
parataxis |
%,significant |
R2743 |
T13652 |
T13653 |
advmod |
approximately,90 |
R2744 |
T13519 |
T13511 |
prep |
in,over-express |
R2745 |
T13653 |
T13651 |
nummod |
90,% |
R2746 |
T13654 |
T13651 |
punct |
),% |
R2747 |
T13655 |
T13649 |
cc |
but,significant |
R2748 |
T13520 |
T13521 |
det |
the,system |
R2749 |
T13656 |
T13655 |
neg |
not,but |
R2750 |
T13657 |
T13649 |
conj |
complete,significant |
R2751 |
T13658 |
T13659 |
punct |
(,Oakley |
R2752 |
T13521 |
T13519 |
pobj |
system,in |
R2753 |
T13659 |
T13625 |
meta |
Oakley,showed |
R2754 |
T13660 |
T13659 |
nmod |
et,Oakley |
R2755 |
T13661 |
T13659 |
nmod |
al.,Oakley |
R2756 |
T13522 |
T13521 |
amod |
central,system |
R2757 |
T13662 |
T13659 |
nummod |
1995,Oakley |
R2758 |
T13663 |
T13659 |
punct |
),Oakley |
R2759 |
T13664 |
T13625 |
punct |
.,showed |
R2760 |
T13523 |
T13521 |
amod |
nervous,system |
R2761 |
T13666 |
T13667 |
nsubj |
Ringstedt,argue |
R2762 |
T13524 |
T13506 |
punct |
", ",altered |
R2763 |
T13668 |
T13669 |
advmod |
et,al. |
R2764 |
T13669 |
T13666 |
advmod |
al.,Ringstedt |
R2765 |
T13525 |
T13526 |
det |
the,course |
R2766 |
T13670 |
T13666 |
punct |
(,Ringstedt |
R2767 |
T13671 |
T13666 |
npadvmod |
1997,Ringstedt |
R2768 |
T13672 |
T13666 |
punct |
),Ringstedt |
R2769 |
T13673 |
T13674 |
mark |
that,disrupts |
R2770 |
T13526 |
T13506 |
nsubjpass |
course,altered |
R2771 |
T13527 |
T13526 |
prep |
of,course |
R2772 |
T13674 |
T13667 |
ccomp |
disrupts,argue |
R2773 |
T13675 |
T13676 |
mark |
while,navigate |
R2774 |
T13528 |
T13529 |
det |
the,afferents |
R2775 |
T13676 |
T13674 |
advcl |
navigate,disrupts |
R2776 |
T13529 |
T13527 |
pobj |
afferents,of |
R2777 |
T13530 |
T13529 |
amod |
proprioceptive,afferents |
R2778 |
T13531 |
T13506 |
auxpass |
are,altered |
R2779 |
T13677 |
T13678 |
amod |
central,axons |
R2780 |
T13678 |
T13676 |
nsubj |
axons,navigate |
R2781 |
T13532 |
T13506 |
cc |
and,altered |
R2782 |
T13679 |
T13678 |
amod |
sensory,axons |
R2783 |
T13680 |
T13676 |
aux |
may,navigate |
R2784 |
T13681 |
T13676 |
advmod |
still,navigate |
R2785 |
T13533 |
T13506 |
conj |
directed,altered |
R2786 |
T13682 |
T13676 |
advmod |
properly,navigate |
R2787 |
T13683 |
T13676 |
prep |
in,navigate |
R2788 |
T13534 |
T13533 |
prep |
towards,directed |
R2789 |
T13684 |
T13685 |
det |
the,absence |
R2790 |
T13535 |
T13536 |
det |
the,regions |
R2791 |
T13685 |
T13683 |
pobj |
absence,in |
R2792 |
T13686 |
T13685 |
prep |
of,absence |
R2793 |
T13687 |
T13686 |
pobj |
NT,of |
R2794 |
T13688 |
T13687 |
punct |
-,NT |
R2795 |
T13689 |
T13687 |
nummod |
3,NT |
R2796 |
T13690 |
T13674 |
punct |
", ",disrupts |
R2797 |
T13691 |
T13692 |
amod |
ectopic,expression |
R2798 |
T13692 |
T13674 |
nsubj |
expression,disrupts |
R2799 |
T13536 |
T13534 |
pobj |
regions,towards |
R2800 |
T13693 |
T13692 |
prep |
of,expression |
R2801 |
T13694 |
T13693 |
pobj |
NT,of |
R2802 |
T13695 |
T13694 |
punct |
-,NT |
R2803 |
T13537 |
T13536 |
prep |
with,regions |
R2804 |
T13696 |
T13694 |
nummod |
3,NT |
R2805 |
T13697 |
T13698 |
poss |
their,targeting |
R2806 |
T13698 |
T13674 |
dobj |
targeting,disrupts |
R2807 |
T13538 |
T13539 |
amod |
high,levels |
R2808 |
T13699 |
T13667 |
punct |
.,argue |
R2809 |
T13539 |
T13537 |
pobj |
levels,with |
R2810 |
T13701 |
T13702 |
advmod |
Recently,suggested |
R2811 |
T13703 |
T13702 |
punct |
", ",suggested |
R2812 |
T13540 |
T13539 |
prep |
of,levels |
R2813 |
T13704 |
T13705 |
det |
another,member |
R2814 |
T13705 |
T13702 |
nsubjpass |
member,suggested |
R2815 |
T13706 |
T13705 |
prep |
of,member |
R2816 |
T13541 |
T13542 |
amod |
ectopic,expression |
R2817 |
T13707 |
T13708 |
det |
the,family |
R2818 |
T13708 |
T13706 |
pobj |
family,of |
R2819 |
T13709 |
T13708 |
compound |
neurotrophin,family |
R2820 |
T13542 |
T13540 |
pobj |
expression,of |
R2821 |
T13710 |
T13705 |
punct |
", ",member |
R2822 |
T13711 |
T13705 |
appos |
BDNF,member |
R2823 |
T13712 |
T13702 |
punct |
", ",suggested |
R2824 |
T13543 |
T13542 |
nmod |
NT,expression |
R2825 |
T13713 |
T13702 |
aux |
has,suggested |
R2826 |
T13714 |
T13702 |
auxpass |
been,suggested |
R2827 |
T13715 |
T13716 |
aux |
to,act |
R2828 |
T13544 |
T13543 |
punct |
-,NT |
R2829 |
T13716 |
T13702 |
xcomp |
act,suggested |
R2830 |
T13717 |
T13716 |
prep |
as,act |
R2831 |
T13545 |
T13543 |
nummod |
3,NT |
R2832 |
T13546 |
T13536 |
prep |
in,regions |
R2833 |
T13547 |
T13548 |
det |
the,cord |
R2834 |
T13718 |
T13719 |
det |
a,chemoattractant |
R2835 |
T13548 |
T13546 |
pobj |
cord,in |
R2836 |
T13719 |
T13717 |
pobj |
chemoattractant,as |
R2837 |
T13720 |
T13719 |
prep |
for,chemoattractant |
R2838 |
T13721 |
T13722 |
amod |
sensory,axons |
R2839 |
T13549 |
T13548 |
amod |
spinal,cord |
R2840 |
T13722 |
T13723 |
nmod |
axons,ear |
R2841 |
T13723 |
T13720 |
pobj |
ear,for |
R2842 |
T13724 |
T13723 |
amod |
innervating,ear |
R2843 |
T13725 |
T13726 |
punct |
(,Tessarollo |
R2844 |
T13726 |
T13702 |
meta |
Tessarollo,suggested |
R2845 |
T13550 |
T13551 |
punct |
(,Ringstedt |
R2846 |
T13727 |
T13726 |
nmod |
et,Tessarollo |
R2847 |
T13728 |
T13726 |
nmod |
al.,Tessarollo |
R2848 |
T13729 |
T13726 |
nummod |
2004,Tessarollo |
R2849 |
T13730 |
T13726 |
punct |
),Tessarollo |
R2850 |
T13551 |
T13533 |
meta |
Ringstedt,directed |
R2851 |
T13731 |
T13702 |
punct |
.,suggested |
R2852 |
T13733 |
T13734 |
prep |
In,rerouted |
R2853 |
T13552 |
T13551 |
nmod |
et,Ringstedt |
R2854 |
T13735 |
T13736 |
det |
a,strategy |
R2855 |
T13553 |
T13551 |
nmod |
al.,Ringstedt |
R2856 |
T13736 |
T13733 |
pobj |
strategy,In |
R2857 |
T13737 |
T13738 |
compound |
gene,replacement |
R2858 |
T13738 |
T13736 |
compound |
replacement,strategy |
R2859 |
T13554 |
T13551 |
nummod |
1997,Ringstedt |
R2860 |
T13739 |
T13740 |
prep |
in,driven |
R2861 |
T13740 |
T13736 |
relcl |
driven,strategy |
R2862 |
T13741 |
T13739 |
pobj |
which,in |
R2863 |
T13555 |
T13551 |
punct |
),Ringstedt |
R2864 |
T13742 |
T13743 |
compound |
BDNF,expression |
R2865 |
T13743 |
T13740 |
nsubjpass |
expression,driven |
R2866 |
T13744 |
T13740 |
auxpass |
was,driven |
R2867 |
T13556 |
T13506 |
punct |
.,altered |
R2868 |
T13745 |
T13740 |
agent |
by,driven |
R2869 |
T13746 |
T13747 |
det |
the,promoter |
R2871 |
T13558 |
T13559 |
nsubj |
Ringstedt,considered |
R2872 |
T13748 |
T13747 |
nmod |
NT,promoter |
R2873 |
T13749 |
T13748 |
punct |
-,NT |
R2874 |
T13750 |
T13748 |
nummod |
3,NT |
R2875 |
T13751 |
T13734 |
punct |
", ",rerouted |
R2876 |
T13560 |
T13561 |
advmod |
et,al. |
R2877 |
T13752 |
T13753 |
amod |
vestibular,axons |
R2878 |
T13753 |
T13734 |
nsubj |
axons,rerouted |
R2879 |
T13754 |
T13734 |
prep |
towards,rerouted |
R2880 |
T13755 |
T13756 |
amod |
ectopic,sources |
R2881 |
T13561 |
T13558 |
advmod |
al.,Ringstedt |
R2882 |
T13756 |
T13754 |
pobj |
sources,towards |
R2883 |
T13757 |
T13756 |
prep |
of,sources |
R2884 |
T13758 |
T13757 |
pobj |
BDNF,of |
R2885 |
T13562 |
T13563 |
det |
the,possibility |
R2886 |
T13759 |
T13756 |
prep |
in,sources |
R2887 |
T13760 |
T13761 |
det |
the,cochlea |
R2888 |
T13563 |
T13559 |
dobj |
possibility,considered |
R2889 |
T13761 |
T13759 |
pobj |
cochlea,in |
R2890 |
T13762 |
T13763 |
dep |
that,expressed |
R2891 |
T13564 |
T13565 |
mark |
that,play |
R2892 |
T13763 |
T13756 |
relcl |
expressed,sources |
R2893 |
T13565 |
T13563 |
acl |
play,possibility |
R2894 |
T13764 |
T13763 |
advmod |
normally,expressed |
R2895 |
T13765 |
T13763 |
dobj |
NT,expressed |
R2896 |
T13766 |
T13765 |
punct |
-,NT |
R2897 |
T13767 |
T13765 |
nummod |
3,NT |
R2898 |
T13768 |
T13734 |
cc |
and,rerouted |
R2899 |
T13566 |
T13565 |
nsubj |
NT,play |
R2900 |
T13769 |
T13770 |
auxpass |
were,innervated |
R2901 |
T13770 |
T13734 |
conj |
innervated,rerouted |
R2902 |
T13771 |
T13770 |
neg |
not,innervated |
R2903 |
T13567 |
T13566 |
punct |
-,NT |
R2904 |
T13772 |
T13770 |
agent |
by,innervated |
R2905 |
T13773 |
T13774 |
det |
these,axons |
R2906 |
T13774 |
T13772 |
pobj |
axons,by |
R2907 |
T13568 |
T13566 |
nummod |
3,NT |
R2908 |
T13775 |
T13734 |
punct |
.,rerouted |
R2909 |
T13569 |
T13565 |
aux |
may,play |
R2910 |
T13777 |
T13778 |
amod |
Ectopic,NT |
R2911 |
T13778 |
T13779 |
nsubj |
NT,induce |
R2912 |
T13570 |
T13571 |
det |
a,role |
R2913 |
T13780 |
T13778 |
punct |
-,NT |
R2914 |
T13781 |
T13778 |
nummod |
3,NT |
R2915 |
T13782 |
T13778 |
acl |
supplied,NT |
R2916 |
T13571 |
T13565 |
dobj |
role,play |
R2917 |
T13889 |
T13867 |
punct |
.,are |
R2918 |
T13783 |
T13782 |
advcl |
using,supplied |
R2919 |
T13891 |
T13892 |
advmod |
Previously,rescued |
R2920 |
T13784 |
T13785 |
amod |
osmotic,pumps |
R2921 |
T13785 |
T13783 |
dobj |
pumps,using |
R2922 |
T13786 |
T13785 |
cc |
and,pumps |
R2923 |
T13787 |
T13788 |
npadvmod |
adenovirus,mediated |
R2924 |
T13893 |
T13892 |
punct |
", ",rescued |
R2925 |
T13788 |
T13790 |
amod |
mediated,expression |
R2926 |
T13789 |
T13788 |
punct |
-,mediated |
R2927 |
T13790 |
T13785 |
conj |
expression,pumps |
R2928 |
T13791 |
T13792 |
amod |
sensory,growth |
R2929 |
T13894 |
T13895 |
amod |
normal,innervation |
R2930 |
T13792 |
T13779 |
dobj |
growth,induce |
R2931 |
T13793 |
T13792 |
compound |
axon,growth |
R2932 |
T13794 |
T13779 |
prep |
during,induce |
R2933 |
T13895 |
T13892 |
nsubjpass |
innervation,rescued |
R2934 |
T13795 |
T13794 |
pobj |
regeneration,during |
R2935 |
T13796 |
T13797 |
punct |
(,Zhang |
R2936 |
T13797 |
T13779 |
meta |
Zhang,induce |
R2937 |
T13896 |
T13897 |
compound |
motor,neuron |
R2938 |
T13798 |
T13797 |
nmod |
et,Zhang |
R2939 |
T13799 |
T13797 |
nmod |
al.,Zhang |
R2940 |
T13800 |
T13797 |
nummod |
1998,Zhang |
R2941 |
T13897 |
T13895 |
compound |
neuron,innervation |
R2942 |
T13801 |
T13797 |
punct |
", ",Zhang |
R2943 |
T13802 |
T13797 |
nmod |
Bradbury,Zhang |
R2944 |
T13898 |
T13892 |
auxpass |
was,rescued |
R2945 |
T13803 |
T13797 |
nmod |
et,Zhang |
R2946 |
T13804 |
T13797 |
nmod |
al.,Zhang |
R2947 |
T13805 |
T13797 |
nummod |
1999,Zhang |
R2948 |
T13806 |
T13797 |
punct |
", ",Zhang |
R2949 |
T13807 |
T13797 |
nmod |
Oudega,Zhang |
R2950 |
T13808 |
T13797 |
nmod |
et,Zhang |
R2951 |
T13899 |
T13892 |
prep |
in,rescued |
R2952 |
T13809 |
T13797 |
nmod |
al.,Zhang |
R2953 |
T13810 |
T13797 |
nummod |
1999,Zhang |
R2954 |
T13900 |
T13901 |
nmod |
NT,KO |
R2955 |
T13811 |
T13797 |
punct |
", ",Zhang |
R2956 |
T13812 |
T13797 |
nmod |
Ramer,Zhang |
R2957 |
T13813 |
T13797 |
nmod |
et,Zhang |
R2958 |
T13901 |
T13904 |
compound |
KO,animals |
R2959 |
T13814 |
T13797 |
nmod |
al.,Zhang |
R2960 |
T13815 |
T13797 |
nummod |
2002,Zhang |
R2961 |
T13816 |
T13797 |
punct |
),Zhang |
R2962 |
T13902 |
T13900 |
punct |
-,NT |
R2963 |
T13817 |
T13779 |
punct |
", ",induce |
R2964 |
T13818 |
T13779 |
cc |
and,induce |
R2965 |
T13819 |
T13779 |
conj |
induce,induce |
R2966 |
T13903 |
T13900 |
nummod |
3,NT |
R2967 |
T13820 |
T13821 |
amod |
axonal,plasticity |
R2968 |
T13821 |
T13819 |
dobj |
plasticity,induce |
R2969 |
T13822 |
T13821 |
prep |
of,plasticity |
R2970 |
T13904 |
T13899 |
pobj |
animals,in |
R2971 |
T13823 |
T13824 |
amod |
corticospinal,axons |
R2972 |
T13824 |
T13822 |
pobj |
axons,of |
R2973 |
T13825 |
T13819 |
prep |
in,induce |
R2974 |
T13905 |
T13892 |
prep |
by,rescued |
R2975 |
T13826 |
T13827 |
amod |
injured,cord |
R2976 |
T13827 |
T13825 |
pobj |
cord,in |
R2977 |
T13828 |
T13827 |
amod |
adult,cord |
R2978 |
T13906 |
T13905 |
pcomp |
over-expressing,by |
R2979 |
T13829 |
T13827 |
amod |
spinal,cord |
R2980 |
T13830 |
T13831 |
punct |
(,Zhou |
R2981 |
T13831 |
T13827 |
meta |
Zhou,cord |
R2982 |
T13907 |
T13906 |
dobj |
NT,over-expressing |
R2983 |
T13832 |
T13831 |
nmod |
et,Zhou |
R2984 |
T13833 |
T13831 |
nmod |
al.,Zhou |
R2985 |
T13834 |
T13831 |
nummod |
2003,Zhou |
R2986 |
T13908 |
T13907 |
punct |
-,NT |
R2987 |
T13835 |
T13831 |
punct |
),Zhou |
R2988 |
T13836 |
T13827 |
punct |
", ",cord |
R2989 |
T13909 |
T13907 |
nummod |
3,NT |
R2990 |
T13837 |
T13838 |
advmod |
where,cross |
R2991 |
T13838 |
T13827 |
relcl |
cross,cord |
R2992 |
T13910 |
T13906 |
advmod |
selectively,over-expressing |
R2993 |
T13839 |
T13840 |
det |
the,axons |
R2994 |
T13840 |
T13838 |
nsubj |
axons,cross |
R2995 |
T13841 |
T13840 |
amod |
sprouting,axons |
R2996 |
T13911 |
T13906 |
prep |
in,over-expressing |
R2997 |
T13842 |
T13840 |
prep |
from,axons |
R2998 |
T13843 |
T13844 |
det |
the,site |
R2999 |
T13844 |
T13842 |
pobj |
site,from |
R3000 |
T13845 |
T13844 |
amod |
intact,site |
R3001 |
T13912 |
T13913 |
poss |
their,muscles |
R3002 |
T13846 |
T13847 |
det |
the,midline |
R3003 |
T13847 |
T13838 |
dobj |
midline,cross |
R3004 |
T13848 |
T13838 |
prep |
towards,cross |
R3005 |
T13913 |
T13911 |
pobj |
muscles,in |
R3006 |
T13849 |
T13850 |
det |
the,source |
R3007 |
T13850 |
T13848 |
pobj |
source,towards |
R3008 |
T13914 |
T13915 |
punct |
(,Wright |
R3009 |
T13851 |
T13850 |
nmod |
NT,source |
R3010 |
T13852 |
T13851 |
punct |
-,NT |
R3011 |
T13915 |
T13892 |
meta |
Wright,rescued |
R3012 |
T13853 |
T13851 |
nummod |
3,NT |
R3013 |
T13854 |
T13838 |
prep |
on,cross |
R3014 |
T13916 |
T13915 |
nmod |
et,Wright |
R3015 |
T13855 |
T13856 |
det |
the,side |
R3016 |
T13856 |
T13854 |
pobj |
side,on |
R3017 |
T13857 |
T13856 |
compound |
lesion,side |
R3018 |
T13917 |
T13915 |
nmod |
al.,Wright |
R3019 |
T13858 |
T13856 |
prep |
of,side |
R3020 |
T13859 |
T13860 |
det |
the,cord |
R3021 |
T13860 |
T13858 |
pobj |
cord,of |
R3022 |
T13918 |
T13915 |
nummod |
1997,Wright |
R3023 |
T13861 |
T13860 |
amod |
spinal,cord |
R3024 |
T13862 |
T13779 |
punct |
.,induce |
R3025 |
T13919 |
T13915 |
punct |
),Wright |
R3026 |
T13864 |
T13865 |
poss |
Our,results |
R3027 |
T13865 |
T13867 |
nsubj |
results,are |
R3028 |
T13866 |
T13865 |
amod |
present,results |
R3029 |
T13920 |
T13892 |
punct |
.,rescued |
R3030 |
T13868 |
T13867 |
prep |
in,are |
R3031 |
T13869 |
T13868 |
pobj |
agreement,in |
R3032 |
T13922 |
T13923 |
nsubj |
It,appears |
R3033 |
T13870 |
T13869 |
prep |
with,agreement |
R3034 |
T13871 |
T13872 |
det |
these,observations |
R3035 |
T13872 |
T13870 |
pobj |
observations,with |
R3036 |
T13873 |
T13867 |
punct |
", ",are |
R3037 |
T13924 |
T13925 |
mark |
that,is |
R3038 |
T13874 |
T13867 |
cc |
and,are |
R3039 |
T13875 |
T13867 |
conj |
provide,are |
R3040 |
T13876 |
T13877 |
amod |
further,evidence |
R3041 |
T13877 |
T13875 |
dobj |
evidence,provide |
R3043 |
T13878 |
T13879 |
mark |
that,acts |
R3044 |
T13879 |
T13877 |
acl |
acts,evidence |
R3045 |
T13880 |
T13879 |
nsubj |
NT,acts |
R3046 |
T13926 |
T13927 |
amod |
peripheral,NT |
R3047 |
T13881 |
T13880 |
punct |
-,NT |
R3048 |
T13882 |
T13880 |
nummod |
3,NT |
R3049 |
T13883 |
T13879 |
prep |
as,acts |
R3050 |
T13927 |
T13925 |
nsubj |
NT,is |
R3051 |
T13884 |
T13885 |
det |
a,chemoattractant |
R3052 |
T13885 |
T13883 |
pobj |
chemoattractant,as |
R3053 |
T13886 |
T13879 |
prep |
for,acts |
R3054 |
T13887 |
T13888 |
amod |
sensory,afferents |
R3055 |
T13888 |
T13886 |
pobj |
afferents,for |
R3056 |
T13928 |
T13927 |
punct |
-,NT |
R3057 |
T13929 |
T13927 |
nummod |
3,NT |
R3058 |
T13995 |
T13994 |
cc |
and,Chen |
R3059 |
T13930 |
T13927 |
advmod |
alone,NT |
R3060 |
T13996 |
T13994 |
conj |
Frank,Chen |
R3061 |
T13997 |
T13996 |
nummod |
1999,Frank |
R3062 |
T13998 |
T13996 |
punct |
),Frank |
R3063 |
T13999 |
T13975 |
punct |
.,raised |
R3064 |
T13931 |
T13925 |
acomp |
sufficient,is |
R3065 |
T14001 |
T14002 |
nsubj |
Assays,be |
R3066 |
T13932 |
T13931 |
prep |
for,sufficient |
R3067 |
T14003 |
T14004 |
aux |
to,determine |
R3068 |
T14004 |
T14001 |
advcl |
determine,Assays |
R3069 |
T13933 |
T13932 |
pobj |
rescuing,for |
R3070 |
T14005 |
T14006 |
mark |
whether,is |
R3071 |
T14006 |
T14004 |
ccomp |
is,determine |
R3072 |
T14007 |
T14008 |
det |
any,NT |
R3073 |
T13934 |
T13935 |
amod |
proprioceptive,neurons |
R3074 |
T14008 |
T14006 |
nsubj |
NT,is |
R3075 |
T14009 |
T14008 |
punct |
-,NT |
R3076 |
T13935 |
T13933 |
dobj |
neurons,rescuing |
R3077 |
T14010 |
T14008 |
nummod |
3,NT |
R3078 |
T14011 |
T14006 |
acomp |
present,is |
R3079 |
T14012 |
T14006 |
prep |
in,is |
R3080 |
T13936 |
T13933 |
prep |
in,rescuing |
R3081 |
T14013 |
T14014 |
det |
the,horns |
R3082 |
T14014 |
T14012 |
pobj |
horns,in |
R3083 |
T14015 |
T14014 |
amod |
ventral,horns |
R3084 |
T13937 |
T13938 |
nmod |
NT,KO |
R3085 |
T14016 |
T14014 |
prep |
of,horns |
R3086 |
T14017 |
T14018 |
det |
these,mice |
R3087 |
T14018 |
T14016 |
pobj |
mice,of |
R3088 |
T13938 |
T13941 |
compound |
KO,animals |
R3089 |
T14019 |
T14002 |
aux |
would,be |
R3090 |
T13939 |
T13937 |
punct |
-,NT |
R3091 |
T14020 |
T14002 |
acomp |
informative,be |
R3092 |
T13940 |
T13937 |
nummod |
3,NT |
R3093 |
T14021 |
T14002 |
punct |
.,be |
R3094 |
T13941 |
T13936 |
pobj |
animals,in |
R3095 |
T14023 |
T14024 |
advmod |
Recently,reported |
R3096 |
T14025 |
T14024 |
punct |
", ",reported |
R3097 |
T13942 |
T13933 |
cc |
and,rescuing |
R3098 |
T14026 |
T14024 |
nsubj |
Patel,reported |
R3099 |
T14027 |
T14028 |
advmod |
et,al. |
R3100 |
T13943 |
T13944 |
amod |
proper,pathfinding |
R3101 |
T14028 |
T14026 |
advmod |
al.,Patel |
R3102 |
T14029 |
T14026 |
punct |
(,Patel |
R3103 |
T14030 |
T14026 |
npadvmod |
2003,Patel |
R3104 |
T14031 |
T14026 |
punct |
),Patel |
R3105 |
T14032 |
T14033 |
poss |
their,observations |
R3106 |
T14033 |
T14024 |
dobj |
observations,reported |
R3107 |
T13944 |
T13933 |
conj |
pathfinding,rescuing |
R3108 |
T14034 |
T14033 |
prep |
on,observations |
R3109 |
T14035 |
T14036 |
nmod |
Bax,KO |
R3110 |
T14036 |
T14042 |
compound |
KO,mice |
R3111 |
T13945 |
T13944 |
amod |
axonal,pathfinding |
R3112 |
T14037 |
T14035 |
punct |
/,Bax |
R3113 |
T14038 |
T14035 |
appos |
NT,Bax |
R3114 |
T13946 |
T13944 |
prep |
in,pathfinding |
R3115 |
T14039 |
T14038 |
punct |
-,NT |
R3116 |
T14040 |
T14038 |
nummod |
3,NT |
R3117 |
T14041 |
T14036 |
amod |
double,KO |
R3118 |
T14042 |
T14034 |
pobj |
mice,on |
R3119 |
T14043 |
T14044 |
nsubj |
they,bred |
R3120 |
T13947 |
T13948 |
det |
the,cord |
R3121 |
T14044 |
T14042 |
advcl |
bred,mice |
R3122 |
T14045 |
T14024 |
punct |
.,reported |
R3123 |
T13948 |
T13946 |
pobj |
cord,in |
R3124 |
T14047 |
T14048 |
poss |
Their,results |
R3125 |
T14048 |
T14049 |
nsubj |
results,are |
R3126 |
T14050 |
T14049 |
advmod |
significantly,are |
R3127 |
T13949 |
T13948 |
amod |
spinal,cord |
R3128 |
T14051 |
T14049 |
acomp |
different,are |
R3129 |
T14052 |
T14051 |
prep |
from,different |
R3130 |
T14053 |
T14052 |
pobj |
ours,from |
R3131 |
T13950 |
T13923 |
punct |
.,appears |
R3132 |
T14054 |
T14049 |
punct |
.,are |
R3133 |
T14056 |
T14057 |
nsubj |
They,see |
R3134 |
T13952 |
T13953 |
advmod |
However,is |
R3135 |
T14058 |
T14059 |
det |
no,afferents |
R3136 |
T14059 |
T14057 |
dobj |
afferents,see |
R3137 |
T14060 |
T14059 |
amod |
proprioceptive,afferents |
R3138 |
T13954 |
T13953 |
punct |
", ",is |
R3139 |
T14061 |
T14057 |
prep |
in,see |
R3140 |
T14062 |
T14063 |
det |
the,periphery |
R3141 |
T14063 |
T14061 |
pobj |
periphery,in |
R3142 |
T14064 |
T14063 |
prep |
of,periphery |
R3143 |
T13955 |
T13953 |
nsubj |
it,is |
R3144 |
T14065 |
T14066 |
det |
the,knockouts |
R3145 |
T14066 |
T14064 |
pobj |
knockouts,of |
R3146 |
T14067 |
T14066 |
amod |
double,knockouts |
R3147 |
T13956 |
T13953 |
acomp |
unclear,is |
R3148 |
T14068 |
T14057 |
cc |
and,see |
R3149 |
T14069 |
T14057 |
conj |
note,see |
R3150 |
T14070 |
T14071 |
mark |
that,terminate |
R3151 |
T13957 |
T13958 |
mark |
whether,is |
R3152 |
T14071 |
T14069 |
ccomp |
terminate,note |
R3153 |
T14072 |
T14073 |
amod |
central,afferents |
R3154 |
T14073 |
T14071 |
nsubj |
afferents,terminate |
R3155 |
T14074 |
T14073 |
amod |
proprioceptive,afferents |
R3156 |
T14075 |
T14071 |
prep |
in,terminate |
R3157 |
T14076 |
T14077 |
det |
the,cord |
R3158 |
T14077 |
T14075 |
pobj |
cord,in |
R3159 |
T14078 |
T14077 |
amod |
intermediate,cord |
R3160 |
T14079 |
T14077 |
amod |
spinal,cord |
R3161 |
T13958 |
T13953 |
ccomp |
is,is |
R3162 |
T14080 |
T14071 |
prep |
without,terminate |
R3163 |
T14081 |
T14080 |
pcomp |
extending,without |
R3164 |
T14082 |
T14081 |
advmod |
ventrally,extending |
R3165 |
T13959 |
T13958 |
nsubj |
NT,is |
R3166 |
T14083 |
T14057 |
punct |
.,see |
R3167 |
T14085 |
T14086 |
poss |
Their,observations |
R3168 |
T13960 |
T13959 |
punct |
-,NT |
R3169 |
T14086 |
T14087 |
nsubjpass |
observations,based |
R3170 |
T14088 |
T14087 |
auxpass |
are,based |
R3171 |
T13961 |
T13959 |
nummod |
3,NT |
R3172 |
T14089 |
T14087 |
prep |
on,based |
R3173 |
T14090 |
T14091 |
compound |
PV,immunostaining |
R3174 |
T14091 |
T14089 |
pobj |
immunostaining,on |
R3175 |
T13962 |
T13958 |
acomp |
absent,is |
R3176 |
T14092 |
T14091 |
cc |
and,immunostaining |
R3177 |
T14093 |
T14094 |
compound |
DiI,labeling |
R3178 |
T14094 |
T14091 |
conj |
labeling,immunostaining |
R3179 |
T14095 |
T14091 |
prep |
of,immunostaining |
R3180 |
T14096 |
T14097 |
det |
the,nerves |
R3181 |
T13963 |
T13962 |
prep |
from,absent |
R3182 |
T14097 |
T14095 |
pobj |
nerves,of |
R3183 |
T14098 |
T14097 |
amod |
peripheral,nerves |
R3184 |
T14099 |
T14087 |
punct |
.,based |
R3185 |
T13964 |
T13965 |
det |
the,cords |
R3186 |
T13965 |
T13963 |
pobj |
cords,from |
R3187 |
T14101 |
T14102 |
nsubj |
We,noted |
R3188 |
T13966 |
T13965 |
amod |
ventral,cords |
R3189 |
T14103 |
T14104 |
mark |
that,is |
R3190 |
T14104 |
T14102 |
ccomp |
is,noted |
R3191 |
T14105 |
T14106 |
compound |
PV,immunolabeling |
R3192 |
T13967 |
T13965 |
amod |
spinal,cords |
R3193 |
T14106 |
T14104 |
nsubj |
immunolabeling,is |
R3194 |
T14107 |
T14104 |
acomp |
diminished,is |
R3195 |
T14108 |
T14104 |
prep |
in,is |
R3196 |
T13968 |
T13965 |
prep |
of,cords |
R3197 |
T14109 |
T14110 |
poss |
our,KOs |
R3198 |
T13969 |
T13970 |
det |
these,animals |
R3199 |
T13970 |
T13968 |
pobj |
animals,of |
R3200 |
T13971 |
T13953 |
punct |
.,is |
R3201 |
T14110 |
T14108 |
pobj |
KOs,in |
R3202 |
T13973 |
T13974 |
det |
The,possibility |
R3203 |
T14111 |
T14110 |
nmod |
Bax,KOs |
R3204 |
T14112 |
T14111 |
punct |
/,Bax |
R3205 |
T14113 |
T14111 |
appos |
NT,Bax |
R3206 |
T14114 |
T14113 |
punct |
-,NT |
R3207 |
T14115 |
T14113 |
nummod |
3,NT |
R3208 |
T14116 |
T14110 |
amod |
double,KOs |
R3209 |
T14117 |
T14102 |
punct |
.,noted |
R3210 |
T14119 |
T14120 |
prep |
In,noted |
R3211 |
T13974 |
T13975 |
nsubjpass |
possibility,raised |
R3212 |
T14120 |
T14129 |
ccomp |
noted,reveal |
R3213 |
T14121 |
T14122 |
amod |
various,manipulations |
R3214 |
T13976 |
T13975 |
aux |
has,raised |
R3215 |
T14122 |
T14119 |
pobj |
manipulations,In |
R3216 |
T14123 |
T14122 |
prep |
of,manipulations |
R3217 |
T14124 |
T14125 |
det |
the,neurotrophins |
R3218 |
T14125 |
T14123 |
pobj |
neurotrophins,of |
R3219 |
T14126 |
T14120 |
nsubjpass |
it,noted |
R3220 |
T13977 |
T13975 |
auxpass |
been,raised |
R3223 |
T13978 |
T13979 |
mark |
that,transport |
R3225 |
T14131 |
T14120 |
ccomp |
are,noted |
R3226 |
T14132 |
T14133 |
amod |
molecular,markers |
R3227 |
T13979 |
T13975 |
ccomp |
transport,raised |
R3228 |
T14133 |
T14131 |
nsubj |
markers,are |
R3229 |
T14134 |
T14133 |
prep |
for,markers |
R3230 |
T14135 |
T14136 |
amod |
proprioceptive,axons |
R3231 |
T13980 |
T13981 |
compound |
motor,neurons |
R3232 |
T14136 |
T14134 |
pobj |
axons,for |
R3233 |
T14137 |
T14138 |
amod |
such,as |
R3234 |
T14138 |
T14136 |
prep |
as,axons |
R3235 |
T13981 |
T13979 |
nsubj |
neurons,transport |
R3236 |
T14139 |
T14138 |
pobj |
PV,as |
R3237 |
T14140 |
T14133 |
cc |
or,markers |
R3238 |
T14141 |
T14142 |
nmod |
calcitonin,peptide |
R3239 |
T14142 |
T14133 |
conj |
peptide,markers |
R3240 |
T13982 |
T13979 |
aux |
may,transport |
R3241 |
T14143 |
T14144 |
npadvmod |
gene,related |
R3242 |
T14144 |
T14142 |
amod |
related,peptide |
R3243 |
T14145 |
T14144 |
punct |
-,related |
R3244 |
T14146 |
T14142 |
prep |
for,peptide |
R3245 |
T14147 |
T14148 |
nmod |
nerve,axons |
R3246 |
T13983 |
T13979 |
advmod |
retrogradely,transport |
R3247 |
T14148 |
T14146 |
pobj |
axons,for |
R3248 |
T14149 |
T14150 |
compound |
growth,factor |
R3249 |
T14150 |
T14151 |
npadvmod |
factor,responsive |
R3250 |
T14151 |
T14148 |
amod |
responsive,axons |
R3251 |
T13984 |
T13979 |
dobj |
NT,transport |
R3252 |
T14152 |
T14151 |
punct |
–,responsive |
R3253 |
T14153 |
T14131 |
acomp |
compromised,are |
R3254 |
T14154 |
T14155 |
punct |
(,Ringstedt |
R3255 |
T13985 |
T13984 |
punct |
-,NT |
R3256 |
T14155 |
T14120 |
meta |
Ringstedt,noted |
R3257 |
T14156 |
T14155 |
nmod |
et,Ringstedt |
R3258 |
T14157 |
T14155 |
nmod |
al.,Ringstedt |
R3259 |
T14158 |
T14155 |
nummod |
1997,Ringstedt |
R3260 |
T14159 |
T14155 |
punct |
;,Ringstedt |
R3261 |
T14160 |
T14155 |
nmod |
Patel,Ringstedt |
R3262 |
T13986 |
T13984 |
nummod |
3,NT |
R3263 |
T14161 |
T14155 |
nmod |
et,Ringstedt |
R3264 |
T14162 |
T14155 |
nmod |
al.,Ringstedt |
R3265 |
T14163 |
T14155 |
nummod |
2000,Ringstedt |
R3266 |
T13987 |
T13979 |
prep |
in,transport |
R3267 |
T14164 |
T14155 |
punct |
),Ringstedt |
R3268 |
T14165 |
T14129 |
punct |
", ",reveal |
R3269 |
T14166 |
T14129 |
advmod |
thus,reveal |
R3270 |
T13988 |
T13987 |
pobj |
muscle,in |
R3271 |
T14167 |
T14168 |
compound |
PV,immunostaining |
R3272 |
T14168 |
T14129 |
nsubj |
immunostaining,reveal |
R3273 |
T13989 |
T13979 |
prep |
to,transport |
R3274 |
T14169 |
T14168 |
prep |
in,immunostaining |
R3275 |
T14170 |
T14171 |
nmod |
Bax,KOs |
R3276 |
T14171 |
T14169 |
pobj |
KOs,in |
R3277 |
T13990 |
T13991 |
det |
the,cord |
R3278 |
T14172 |
T14170 |
punct |
/,Bax |
R3279 |
T14173 |
T14170 |
appos |
NT,Bax |
R3280 |
T14174 |
T14173 |
punct |
-,NT |
R3281 |
T13991 |
T13989 |
pobj |
cord,to |
R3282 |
T14175 |
T14173 |
nummod |
3,NT |
R3283 |
T14176 |
T14171 |
amod |
double,KOs |
R3284 |
T14177 |
T14129 |
aux |
can,reveal |
R3285 |
T13992 |
T13991 |
amod |
spinal,cord |
R3286 |
T14178 |
T14129 |
neg |
not,reveal |
R3287 |
T14179 |
T14180 |
det |
the,extent |
R3288 |
T14180 |
T14129 |
dobj |
extent,reveal |
R3289 |
T13993 |
T13994 |
punct |
(,Chen |
R3290 |
T14181 |
T14180 |
prep |
of,extent |
R3291 |
T14182 |
T14183 |
amod |
proprioceptive,axons |
R3292 |
T14183 |
T14181 |
pobj |
axons,of |
R3293 |
T13994 |
T13975 |
meta |
Chen,raised |
R3294 |
T14184 |
T14183 |
prep |
in,axons |
R3295 |
T14185 |
T14186 |
det |
the,periphery |
R3296 |
T14186 |
T14184 |
pobj |
periphery,in |
R3297 |
T14206 |
T14202 |
prep |
in,expressing |
R3298 |
T14187 |
T14129 |
punct |
.,reveal |
R3299 |
T14189 |
T14190 |
compound |
Seventy,three |
R3300 |
T14190 |
T14192 |
nummod |
three,percent |
R3301 |
T14207 |
T14208 |
det |
the,DRG |
R3302 |
T14191 |
T14190 |
punct |
-,three |
R3303 |
T14192 |
T14193 |
nsubjpass |
percent,reported |
R3304 |
T14208 |
T14206 |
pobj |
DRG,in |
R3305 |
T14194 |
T14192 |
prep |
of,percent |
R3306 |
T14195 |
T14196 |
advmod |
retrogradely,labeled |
R3307 |
T14209 |
T14208 |
amod |
adult,DRG |
R3308 |
T14196 |
T14197 |
amod |
labeled,afferents |
R3309 |
T14210 |
T14208 |
compound |
rat,DRG |
R3310 |
T14197 |
T14194 |
pobj |
afferents,of |
R3311 |
T14198 |
T14199 |
compound |
gastrocnemius,muscle |
R3312 |
T14199 |
T14197 |
compound |
muscle,afferents |
R3313 |
T14200 |
T14193 |
auxpass |
were,reported |
R3314 |
T14201 |
T14202 |
aux |
to,expressing |
R3315 |
T14202 |
T14193 |
xcomp |
expressing,reported |
R3316 |
T14211 |
T14193 |
punct |
", ",reported |
R3317 |
T14203 |
T14202 |
aux |
be,expressing |
R3318 |
T14204 |
T14205 |
compound |
TrkC,RNA |
R3319 |
T14212 |
T14213 |
mark |
although,represent |
R3320 |
T14205 |
T14202 |
dobj |
RNA,expressing |
R3321 |
T14213 |
T14193 |
advcl |
represent,reported |
R3322 |
T14214 |
T14213 |
nsubj |
some,represent |
R3323 |
T14215 |
T14214 |
prep |
of,some |
R3324 |
T14312 |
T14309 |
nsubj |
findings,suggest |
R3325 |
T14313 |
T14314 |
det |
a,role |
R3326 |
T14216 |
T14215 |
pobj |
these,of |
R3327 |
T14314 |
T14309 |
dobj |
role,suggest |
R3328 |
T14217 |
T14214 |
punct |
(,some |
R3329 |
T14315 |
T14314 |
prep |
for,role |
R3330 |
T14316 |
T14315 |
pobj |
NT,for |
R3331 |
T14317 |
T14316 |
punct |
-,NT |
R3332 |
T14318 |
T14316 |
nummod |
3,NT |
R3333 |
T14218 |
T14219 |
advmod |
about,10 |
R3334 |
T14319 |
T14314 |
prep |
in,role |
R3335 |
T14320 |
T14319 |
pobj |
initiation,in |
R3336 |
T14219 |
T14220 |
nummod |
10,% |
R3337 |
T14321 |
T14320 |
prep |
of,initiation |
R3338 |
T14322 |
T14323 |
compound |
muscle,innervation |
R3339 |
T14323 |
T14321 |
pobj |
innervation,of |
R3340 |
T14220 |
T14214 |
appos |
%,some |
R3341 |
T14324 |
T14320 |
cc |
and,initiation |
R3342 |
T14325 |
T14326 |
compound |
spindle,differentiation |
R3343 |
T14326 |
T14320 |
conj |
differentiation,initiation |
R3344 |
T14221 |
T14214 |
punct |
),some |
R3345 |
T14327 |
T14326 |
prep |
by,differentiation |
R3346 |
T14328 |
T14329 |
det |
the,axons |
R3347 |
T14329 |
T14327 |
pobj |
axons,by |
R3348 |
T14222 |
T14213 |
aux |
may,represent |
R3349 |
T14330 |
T14329 |
amod |
proprioceptive,axons |
R3350 |
T14331 |
T14309 |
punct |
.,suggest |
R3351 |
T14223 |
T14224 |
amod |
cutaneous,innervation |
R3352 |
T14333 |
T14334 |
nsubj |
Patel,examined |
R3353 |
T14224 |
T14213 |
dobj |
innervation,represent |
R3354 |
T14335 |
T14336 |
advmod |
et,al. |
R3355 |
T14336 |
T14333 |
advmod |
al.,Patel |
R3356 |
T14337 |
T14333 |
punct |
(,Patel |
R3357 |
T14225 |
T14226 |
punct |
(,McMahon |
R3358 |
T14338 |
T14333 |
npadvmod |
2003,Patel |
R3359 |
T14339 |
T14333 |
punct |
),Patel |
R3360 |
T14340 |
T14341 |
npadvmod |
DiI,labeled |
R3361 |
T14226 |
T14193 |
meta |
McMahon,reported |
R3362 |
T14341 |
T14343 |
amod |
labeled,axons |
R3363 |
T14342 |
T14341 |
punct |
-,labeled |
R3364 |
T14343 |
T14334 |
dobj |
axons,examined |
R3365 |
T14344 |
T14343 |
amod |
central,axons |
R3366 |
T14345 |
T14343 |
compound |
DRG,axons |
R3367 |
T14346 |
T14343 |
prep |
in,axons |
R3368 |
T14227 |
T14226 |
nmod |
et,McMahon |
R3369 |
T14347 |
T14348 |
det |
the,cord |
R3370 |
T14348 |
T14346 |
pobj |
cord,in |
R3371 |
T14349 |
T14348 |
amod |
spinal,cord |
R3372 |
T14228 |
T14226 |
nmod |
al.,McMahon |
R3373 |
T14350 |
T14348 |
prep |
of,cord |
R3374 |
T14351 |
T14352 |
nummod |
three,E17 |
R3375 |
T14352 |
T14350 |
pobj |
E17,of |
R3376 |
T14229 |
T14226 |
nummod |
1994,McMahon |
R3377 |
T14353 |
T14352 |
cc |
and,E17 |
R3378 |
T14354 |
T14355 |
nummod |
two,P0 |
R3379 |
T14355 |
T14356 |
compound |
P0,cases |
R3380 |
T14230 |
T14226 |
punct |
),McMahon |
R3381 |
T14356 |
T14352 |
conj |
cases,E17 |
R3382 |
T14357 |
T14334 |
punct |
", ",examined |
R3383 |
T14231 |
T14193 |
punct |
.,reported |
R3384 |
T14358 |
T14334 |
cc |
and,examined |
R3385 |
T14359 |
T14334 |
conj |
report,examined |
R3386 |
T14360 |
T14361 |
mark |
that,stop |
R3387 |
T14233 |
T14234 |
advmod |
Presently,is |
R3388 |
T14361 |
T14359 |
ccomp |
stop,report |
R3389 |
T14362 |
T14363 |
amod |
central,axons |
R3390 |
T14363 |
T14361 |
nsubj |
axons,stop |
R3391 |
T14364 |
T14363 |
amod |
proprioceptive,axons |
R3392 |
T14235 |
T14234 |
punct |
", ",is |
R3393 |
T14365 |
T14361 |
prep |
in,stop |
R3394 |
T14236 |
T14234 |
nsubj |
it,is |
R3395 |
T14366 |
T14367 |
det |
the,laminae |
R3396 |
T14367 |
T14365 |
pobj |
laminae,in |
R3397 |
T14237 |
T14234 |
neg |
not,is |
R3398 |
T14368 |
T14367 |
amod |
intermediate,laminae |
R3399 |
T14369 |
T14361 |
punct |
", ",stop |
R3400 |
T14370 |
T14371 |
neg |
never,entering |
R3401 |
T14238 |
T14234 |
acomp |
clear,is |
R3402 |
T14371 |
T14361 |
advcl |
entering,stop |
R3403 |
T14372 |
T14373 |
det |
the,cord |
R3404 |
T14373 |
T14371 |
dobj |
cord,entering |
R3405 |
T14239 |
T14240 |
mark |
whether,made |
R3406 |
T14374 |
T14373 |
amod |
ventral,cord |
R3407 |
T14375 |
T14334 |
punct |
.,examined |
R3408 |
T14240 |
T14234 |
advcl |
made,is |
R3409 |
T14377 |
T14378 |
nsubj |
We,examined |
R3410 |
T14241 |
T14242 |
compound |
TrkC,protein |
R3411 |
T14379 |
T14378 |
aux |
have,examined |
R3412 |
T14380 |
T14381 |
nummod |
nine,cases |
R3413 |
T14242 |
T14240 |
nsubjpass |
protein,made |
R3414 |
T14381 |
T14378 |
dobj |
cases,examined |
R3415 |
T14382 |
T14383 |
nmod |
Bax,KO |
R3416 |
T14383 |
T14381 |
compound |
KO,cases |
R3417 |
T14384 |
T14382 |
punct |
/,Bax |
R3418 |
T14385 |
T14382 |
appos |
NT,Bax |
R3419 |
T14386 |
T14385 |
punct |
-,NT |
R3420 |
T14387 |
T14385 |
nummod |
3,NT |
R3421 |
T14243 |
T14240 |
auxpass |
is,made |
R3422 |
T14388 |
T14383 |
amod |
double,KO |
R3423 |
T14389 |
T14378 |
punct |
", ",examined |
R3424 |
T14390 |
T14378 |
cc |
and,examined |
R3425 |
T14244 |
T14240 |
advmod |
also,made |
R3426 |
T14391 |
T14392 |
advmod |
often,gives |
R3427 |
T14392 |
T14378 |
conj |
gives,examined |
R3428 |
T14393 |
T14394 |
amod |
incomplete,labeling |
R3429 |
T14245 |
T14240 |
agent |
by,made |
R3430 |
T14394 |
T14392 |
nsubj |
labeling,gives |
R3431 |
T14395 |
T14394 |
compound |
DiI,labeling |
R3432 |
T14396 |
T14397 |
det |
the,impression |
R3433 |
T14246 |
T14247 |
amod |
cutaneous,afferents |
R3434 |
T14397 |
T14392 |
dobj |
impression,gives |
R3435 |
T14398 |
T14399 |
mark |
that,are |
R3436 |
T14399 |
T14397 |
acl |
are,impression |
R3437 |
T14247 |
T14245 |
pobj |
afferents,by |
R3438 |
T14400 |
T14399 |
expl |
there,are |
R3439 |
T14401 |
T14402 |
det |
no,axons |
R3440 |
T14248 |
T14240 |
cc |
and,made |
R3441 |
T14402 |
T14399 |
attr |
axons,are |
R3442 |
T14403 |
T14402 |
acl |
reaching,axons |
R3443 |
T14404 |
T14405 |
det |
the,cord |
R3444 |
T14249 |
T14250 |
mark |
if,so |
R3445 |
T14405 |
T14403 |
dobj |
cord,reaching |
R3446 |
T14406 |
T14405 |
amod |
ventral,cord |
R3447 |
T14407 |
T14405 |
amod |
spinal,cord |
R3448 |
T14250 |
T14251 |
advcl |
so,expressed |
R3449 |
T14408 |
T14392 |
punct |
.,gives |
R3450 |
T14251 |
T14240 |
conj |
expressed,made |
R3451 |
T14410 |
T14411 |
nsubj |
We,seen |
R3452 |
T14412 |
T14411 |
aux |
have,seen |
R3453 |
T14252 |
T14251 |
prep |
at,expressed |
R3454 |
T14413 |
T14411 |
advmod |
also,seen |
R3455 |
T14414 |
T14411 |
dobj |
cases,seen |
R3456 |
T14415 |
T14414 |
amod |
similar,cases |
R3457 |
T14253 |
T14254 |
det |
what,stage |
R3458 |
T14416 |
T14415 |
prep |
to,similar |
R3459 |
T14417 |
T14416 |
pobj |
theirs,to |
R3460 |
T14254 |
T14252 |
pcomp |
stage,at |
R3461 |
T14255 |
T14254 |
prep |
in,stage |
R3462 |
T14256 |
T14255 |
pobj |
development,in |
R3463 |
T14418 |
T14419 |
punct |
(,4 |
R3464 |
T14419 |
T14414 |
parataxis |
4,cases |
R3465 |
T14420 |
T14419 |
nsubj |
n,4 |
R3466 |
T14257 |
T14258 |
det |
this,receptor |
R3467 |
T14421 |
T14419 |
punct |
=,4 |
R3468 |
T14422 |
T14419 |
punct |
),4 |
R3469 |
T14423 |
T14411 |
punct |
", ",seen |
R3470 |
T14424 |
T14411 |
cc |
but,seen |
R3471 |
T14425 |
T14426 |
prep |
at,have |
R3472 |
T14426 |
T14411 |
conj |
have,seen |
R3473 |
T14258 |
T14251 |
nsubjpass |
receptor,expressed |
R3474 |
T14427 |
T14428 |
amod |
higher,magnification |
R3475 |
T14428 |
T14425 |
pobj |
magnification,at |
R3476 |
T14429 |
T14430 |
det |
these,axons |
R3477 |
T14259 |
T14251 |
auxpass |
is,expressed |
R3478 |
T14430 |
T14426 |
nsubj |
axons,have |
R3479 |
T14431 |
T14426 |
aux |
did,have |
R3480 |
T14432 |
T14426 |
neg |
not,have |
R3481 |
T14260 |
T14251 |
agent |
by,expressed |
R3482 |
T14433 |
T14434 |
amod |
terminal,boutons |
R3483 |
T14434 |
T14426 |
dobj |
boutons,have |
R3484 |
T14435 |
T14426 |
cc |
and,have |
R3485 |
T14261 |
T14262 |
amod |
cutaneous,axons |
R3486 |
T14436 |
T14437 |
auxpass |
were,labeled |
R3487 |
T14437 |
T14426 |
conj |
labeled,have |
R3488 |
T14262 |
T14260 |
pobj |
axons,by |
R3489 |
T14438 |
T14437 |
neg |
not,labeled |
R3490 |
T14439 |
T14437 |
advmod |
completely,labeled |
R3491 |
T14440 |
T14426 |
punct |
.,have |
R3492 |
T14263 |
T14234 |
punct |
.,is |
R3493 |
T14442 |
T14443 |
advmod |
However,was |
R3494 |
T14265 |
T14266 |
prep |
Based,think |
R3495 |
T14444 |
T14443 |
punct |
", ",was |
R3496 |
T14445 |
T14443 |
prep |
with,was |
R3497 |
T14446 |
T14447 |
amod |
complete,fills |
R3498 |
T14447 |
T14445 |
pobj |
fills,with |
R3499 |
T14267 |
T14265 |
prep |
on,Based |
R3500 |
T14448 |
T14449 |
punct |
(,5 |
R3501 |
T14449 |
T14447 |
parataxis |
5,fills |
R3502 |
T14450 |
T14449 |
nsubj |
n,5 |
R3503 |
T14268 |
T14269 |
det |
the,evidence |
R3504 |
T14451 |
T14449 |
punct |
=,5 |
R3505 |
T14452 |
T14449 |
punct |
),5 |
R3506 |
T14269 |
T14267 |
pobj |
evidence,on |
R3507 |
T14453 |
T14443 |
punct |
", ",was |
R3508 |
T14270 |
T14269 |
amod |
available,evidence |
R3509 |
T14454 |
T14443 |
nsubj |
it,was |
R3510 |
T14455 |
T14443 |
acomp |
possible,was |
R3511 |
T14271 |
T14269 |
acl |
showing,evidence |
R3512 |
T14456 |
T14457 |
aux |
to,trace |
R3513 |
T14457 |
T14443 |
xcomp |
trace,was |
R3514 |
T14458 |
T14459 |
det |
these,axons |
R3515 |
T14272 |
T14273 |
mark |
that,eliminated |
R3516 |
T14459 |
T14457 |
dobj |
axons,trace |
R3517 |
T14460 |
T14457 |
prep |
into,trace |
R3518 |
T14461 |
T14462 |
det |
the,midline |
R3519 |
T14462 |
T14460 |
pobj |
midline,into |
R3520 |
T14463 |
T14462 |
amod |
ventral,midline |
R3521 |
T14464 |
T14460 |
cc |
and,into |
R3522 |
T14465 |
T14460 |
conj |
across,into |
R3523 |
T14273 |
T14271 |
ccomp |
eliminated,showing |
R3524 |
T14466 |
T14465 |
prep |
to,across |
R3525 |
T14467 |
T14468 |
det |
the,side |
R3526 |
T14274 |
T14275 |
det |
all,neurons |
R3527 |
T14468 |
T14466 |
pobj |
side,to |
R3528 |
T14469 |
T14468 |
amod |
contralateral,side |
R3529 |
T14470 |
T14457 |
punct |
", ",trace |
R3530 |
T14275 |
T14273 |
nsubjpass |
neurons,eliminated |
R3531 |
T14471 |
T14457 |
cc |
and,trace |
R3532 |
T14472 |
T14457 |
conj |
visualize,trace |
R3533 |
T14473 |
T14474 |
amod |
terminal,boutons |
R3534 |
T14276 |
T14275 |
amod |
proprioceptive,neurons |
R3535 |
T14474 |
T14472 |
dobj |
boutons,visualize |
R3536 |
T14475 |
T14474 |
prep |
at,boutons |
R3537 |
T14476 |
T14477 |
poss |
their,tips |
R3538 |
T14277 |
T14273 |
auxpass |
are,eliminated |
R3539 |
T14477 |
T14475 |
pobj |
tips,at |
R3540 |
T14478 |
T14479 |
punct |
(,see |
R3541 |
T14278 |
T14273 |
prep |
in,eliminated |
R3542 |
T14479 |
T14472 |
parataxis |
see,visualize |
R3543 |
T14480 |
T14481 |
compound |
Figure,3C |
R3544 |
T14481 |
T14479 |
dobj |
3C,see |
R3545 |
T14279 |
T14280 |
npadvmod |
NT,null |
R3546 |
T14482 |
T14479 |
punct |
),see |
R3547 |
T14483 |
T14443 |
punct |
.,was |
R3548 |
T14280 |
T14285 |
amod |
null,mice |
R3549 |
T14485 |
T14486 |
advmod |
Previously,reported |
R3550 |
T14281 |
T14279 |
punct |
-,NT |
R3551 |
T14487 |
T14486 |
punct |
", ",reported |
R3552 |
T14488 |
T14486 |
nsubj |
Arber,reported |
R3553 |
T14489 |
T14490 |
advmod |
et,al. |
R3554 |
T14282 |
T14279 |
nummod |
3,NT |
R3555 |
T14490 |
T14488 |
advmod |
al.,Arber |
R3556 |
T14491 |
T14488 |
punct |
(,Arber |
R3557 |
T14492 |
T14488 |
npadvmod |
2000,Arber |
R3558 |
T14283 |
T14279 |
cc |
or,NT |
R3559 |
T14493 |
T14488 |
punct |
),Arber |
R3560 |
T14494 |
T14495 |
mark |
that,expressed |
R3561 |
T14495 |
T14486 |
ccomp |
expressed,reported |
R3562 |
T14284 |
T14279 |
conj |
TrkC,NT |
R3563 |
T14285 |
T14278 |
pobj |
mice,in |
R3564 |
T14496 |
T14495 |
nsubjpass |
members,expressed |
R3565 |
T14286 |
T14266 |
punct |
", ",think |
R3566 |
T14497 |
T14496 |
prep |
of,members |
R3567 |
T14498 |
T14499 |
det |
the,family |
R3568 |
T14499 |
T14497 |
pobj |
family,of |
R3569 |
T14287 |
T14266 |
nsubj |
we,think |
R3570 |
T14500 |
T14499 |
compound |
Ets,family |
R3571 |
T14501 |
T14499 |
prep |
of,family |
R3572 |
T14502 |
T14503 |
compound |
transcription,factors |
R3573 |
T14503 |
T14501 |
pobj |
factors,of |
R3574 |
T14504 |
T14496 |
punct |
", ",members |
R3575 |
T14505 |
T14496 |
appos |
Er81,members |
R3576 |
T14506 |
T14505 |
cc |
and,Er81 |
R3577 |
T14288 |
T14289 |
mark |
that,represents |
R3578 |
T14507 |
T14505 |
conj |
Pea3,Er81 |
R3579 |
T14508 |
T14495 |
punct |
", ",expressed |
R3580 |
T14509 |
T14495 |
auxpass |
are,expressed |
R3581 |
T14289 |
T14266 |
ccomp |
represents,think |
R3582 |
T14510 |
T14495 |
agent |
by,expressed |
R3583 |
T14511 |
T14512 |
compound |
DRG,neurons |
R3584 |
T14512 |
T14510 |
pobj |
neurons,by |
R3585 |
T14290 |
T14291 |
compound |
TrkC,staining |
R3586 |
T14513 |
T14514 |
advmod |
as,as |
R3587 |
T14514 |
T14512 |
cc |
as,neurons |
R3588 |
T14291 |
T14289 |
nsubj |
staining,represents |
R3589 |
T14515 |
T14514 |
advmod |
well,as |
R3590 |
T14516 |
T14517 |
compound |
motor,neurons |
R3591 |
T14517 |
T14512 |
conj |
neurons,neurons |
R3592 |
T14292 |
T14291 |
prep |
in,staining |
R3593 |
T14518 |
T14517 |
cc |
and,neurons |
R3594 |
T14519 |
T14520 |
poss |
their,fibers |
R3595 |
T14520 |
T14517 |
conj |
fibers,neurons |
R3596 |
T14293 |
T14294 |
det |
the,nerve |
R3597 |
T14521 |
T14520 |
compound |
target,fibers |
R3598 |
T14522 |
T14520 |
compound |
muscle,fibers |
R3600 |
T14294 |
T14292 |
pobj |
nerve,in |
R3601 |
T14295 |
T14294 |
amod |
tibial,nerve |
R3602 |
T14296 |
T14289 |
advmod |
mostly,represents |
R3603 |
T14525 |
T14526 |
nsubj |
They,found |
R3604 |
T14297 |
T14298 |
amod |
proprioceptive,axons |
R3605 |
T14527 |
T14528 |
mark |
that,were |
R3606 |
T14298 |
T14289 |
dobj |
axons,represents |
R3607 |
T14299 |
T14298 |
prep |
in,axons |
R3608 |
T14528 |
T14526 |
ccomp |
were,found |
R3609 |
T14300 |
T14301 |
det |
the,vicinity |
R3610 |
T14529 |
T14528 |
prep |
in,were |
R3611 |
T14530 |
T14531 |
det |
the,cord |
R3612 |
T14301 |
T14299 |
pobj |
vicinity,in |
R3613 |
T14531 |
T14529 |
pobj |
cord,in |
R3614 |
T14532 |
T14531 |
amod |
spinal,cord |
R3615 |
T14533 |
T14531 |
prep |
of,cord |
R3616 |
T14302 |
T14301 |
prep |
of,vicinity |
R3617 |
T14534 |
T14535 |
compound |
Er81,KO |
R3618 |
T14535 |
T14536 |
compound |
KO,mice |
R3619 |
T14303 |
T14304 |
poss |
their,target |
R3620 |
T14536 |
T14533 |
pobj |
mice,of |
R3621 |
T14537 |
T14528 |
punct |
", ",were |
R3622 |
T14538 |
T14539 |
amod |
ventral,projections |
R3623 |
T14539 |
T14528 |
nsubj |
projections,were |
R3624 |
T14540 |
T14539 |
prep |
of,projections |
R3625 |
T14541 |
T14542 |
amod |
proprioceptive,axons |
R3626 |
T14542 |
T14540 |
pobj |
axons,of |
R3627 |
T14304 |
T14302 |
pobj |
target,of |
R3628 |
T14543 |
T14544 |
advmod |
mostly,absent |
R3629 |
T14544 |
T14528 |
acomp |
absent,were |
R3630 |
T14545 |
T14528 |
punct |
", ",were |
R3631 |
T14305 |
T14304 |
amod |
peripheral,target |
R3632 |
T14546 |
T14528 |
cc |
and,were |
R3633 |
T14306 |
T14266 |
punct |
.,think |
R3634 |
T14547 |
T14548 |
advmod |
very,axons |
R3635 |
T14548 |
T14550 |
nsubj |
axons,made |
R3636 |
T14549 |
T14548 |
amod |
few,axons |
R3637 |
T14550 |
T14528 |
conj |
made,were |
R3638 |
T14551 |
T14550 |
dobj |
it,made |
R3639 |
T14552 |
T14550 |
prep |
to,made |
R3640 |
T14308 |
T14309 |
advmod |
Altogether,suggest |
R3641 |
T14553 |
T14554 |
det |
the,cord |
R3642 |
T14554 |
T14552 |
pobj |
cord,to |
R3643 |
T14555 |
T14554 |
amod |
ventral,cord |
R3644 |
T14556 |
T14526 |
punct |
.,found |
R3645 |
T14558 |
T14559 |
nsubj |
Patel,note |
R3646 |
T14310 |
T14309 |
punct |
", ",suggest |
R3647 |
T14560 |
T14561 |
advmod |
et,al. |
R3648 |
T14561 |
T14558 |
advmod |
al.,Patel |
R3649 |
T14562 |
T14558 |
punct |
(,Patel |
R3650 |
T14563 |
T14558 |
npadvmod |
2003,Patel |
R3651 |
T14311 |
T14312 |
poss |
our,findings |
R3652 |
T14564 |
T14558 |
punct |
),Patel |
R3653 |
T14565 |
T14566 |
mark |
that,is |
R3654 |
T14566 |
T14559 |
ccomp |
is,note |
R3655 |
T14567 |
T14568 |
det |
the,phenotype |
R3656 |
T14568 |
T14566 |
nsubj |
phenotype,is |
R3657 |
T14630 |
T14628 |
nmod |
KO,mice |
R3658 |
T14569 |
T14570 |
nsubj |
they,observed |
R3659 |
T14570 |
T14568 |
advcl |
observed,phenotype |
R3660 |
T14571 |
T14570 |
prep |
in,observed |
R3661 |
T14572 |
T14573 |
poss |
their,mice |
R3662 |
T14573 |
T14571 |
pobj |
mice,in |
R3663 |
T14574 |
T14575 |
nmod |
Bax,KO |
R3664 |
T14575 |
T14573 |
compound |
KO,mice |
R3665 |
T14576 |
T14574 |
punct |
/,Bax |
R3666 |
T14577 |
T14574 |
appos |
NT,Bax |
R3667 |
T14631 |
T14629 |
punct |
-,NT |
R3668 |
T14578 |
T14577 |
punct |
-,NT |
R3669 |
T14579 |
T14577 |
nummod |
3,NT |
R3670 |
T14580 |
T14575 |
amod |
double,KO |
R3671 |
T14632 |
T14629 |
nummod |
3,NT |
R3672 |
T14581 |
T14582 |
advmod |
quite,similar |
R3673 |
T14582 |
T14566 |
acomp |
similar,is |
R3674 |
T14583 |
T14582 |
prep |
to,similar |
R3675 |
T14584 |
T14583 |
pobj |
that,to |
R3676 |
T14585 |
T14584 |
prep |
of,that |
R3677 |
T14586 |
T14587 |
compound |
Er81,KO |
R3678 |
T14587 |
T14588 |
compound |
KO,mice |
R3679 |
T14588 |
T14585 |
pobj |
mice,of |
R3680 |
T14589 |
T14559 |
punct |
.,note |
R3681 |
T14633 |
T14630 |
cc |
and,KO |
R3682 |
T14591 |
T14592 |
nsubj |
They,provide |
R3683 |
T14593 |
T14592 |
dobj |
evidence,provide |
R3684 |
T14634 |
T14635 |
nmod |
Bax,KO |
R3685 |
T14594 |
T14595 |
mark |
that,induces |
R3686 |
T14595 |
T14593 |
acl |
induces,evidence |
R3687 |
T14635 |
T14630 |
conj |
KO,KO |
R3688 |
T14596 |
T14595 |
nsubj |
NT,induces |
R3689 |
T14597 |
T14596 |
punct |
-,NT |
R3690 |
T14598 |
T14596 |
nummod |
3,NT |
R3691 |
T14636 |
T14634 |
punct |
/,Bax |
R3692 |
T14599 |
T14600 |
compound |
Er81,expression |
R3693 |
T14600 |
T14595 |
dobj |
expression,induces |
R3694 |
T14601 |
T14595 |
prep |
in,induces |
R3695 |
T14637 |
T14634 |
appos |
NT,Bax |
R3696 |
T14602 |
T14603 |
compound |
DRG,explants |
R3697 |
T14603 |
T14601 |
pobj |
explants,in |
R3698 |
T14604 |
T14605 |
advmod |
in,vitro |
R3699 |
T14638 |
T14637 |
punct |
-,NT |
R3700 |
T14605 |
T14595 |
advmod |
vitro,induces |
R3701 |
T14606 |
T14592 |
punct |
.,provide |
R3702 |
T14639 |
T14637 |
nummod |
3,NT |
R3703 |
T14608 |
T14609 |
nsubj |
Patel,report |
R3704 |
T14610 |
T14611 |
advmod |
et,al. |
R3705 |
T14611 |
T14608 |
advmod |
al.,Patel |
R3707 |
T14612 |
T14608 |
punct |
(,Patel |
R3708 |
T14613 |
T14608 |
npadvmod |
2003,Patel |
R3709 |
T14614 |
T14608 |
punct |
),Patel |
R3710 |
T14641 |
T14609 |
punct |
", ",report |
R3711 |
T14615 |
T14616 |
mark |
that,diminished |
R3712 |
T14616 |
T14609 |
ccomp |
diminished,report |
R3713 |
T14617 |
T14618 |
compound |
Er81,expression |
R3714 |
T14642 |
T14643 |
mark |
while,shows |
R3715 |
T14618 |
T14616 |
nsubj |
expression,diminished |
R3716 |
T14619 |
T14618 |
compound |
mRNA,expression |
R3717 |
T14620 |
T14616 |
aux |
is,diminished |
R3718 |
T14643 |
T14609 |
advcl |
shows,report |
R3719 |
T14621 |
T14616 |
punct |
(,diminished |
R3720 |
T14622 |
T14616 |
cc |
but,diminished |
R3721 |
T14623 |
T14624 |
neg |
not,abolished |
R3722 |
T14644 |
T14645 |
poss |
their,immunohistochemistry |
R3723 |
T14624 |
T14616 |
conj |
abolished,diminished |
R3724 |
T14645 |
T14643 |
nsubj |
immunohistochemistry,shows |
R3725 |
T14625 |
T14616 |
punct |
),diminished |
R3726 |
T14626 |
T14616 |
prep |
in,diminished |
R3727 |
T14627 |
T14628 |
preconj |
both,mice |
R3728 |
T14628 |
T14626 |
pobj |
mice,in |
R3729 |
T14629 |
T14630 |
nmod |
NT,KO |
R3730 |
T14646 |
T14647 |
advmod |
much,less |
R3731 |
T14647 |
T14648 |
amod |
less,expression |
R3732 |
T14648 |
T14643 |
dobj |
expression,shows |
R3733 |
T14649 |
T14648 |
compound |
protein,expression |
R3734 |
T14736 |
T14734 |
pobj |
cord,to |
R3735 |
T14737 |
T14736 |
amod |
ventral,cord |
R3736 |
T14650 |
T14643 |
prep |
in,shows |
R3737 |
T14738 |
T14736 |
amod |
spinal,cord |
R3738 |
T14739 |
T14727 |
cc |
and,find |
R3739 |
T14740 |
T14727 |
conj |
target,find |
R3740 |
T14651 |
T14652 |
det |
the,mice |
R3741 |
T14741 |
T14740 |
advmod |
properly,target |
R3742 |
T14742 |
T14740 |
prep |
to,target |
R3743 |
T14743 |
T14744 |
det |
the,neurons |
R3744 |
T14652 |
T14650 |
pobj |
mice,in |
R3745 |
T14744 |
T14742 |
pobj |
neurons,to |
R3746 |
T14745 |
T14744 |
compound |
motor,neurons |
R3747 |
T14653 |
T14654 |
amod |
double,KO |
R3748 |
T14746 |
T14747 |
punct |
(,Arber |
R3749 |
T14747 |
T14725 |
meta |
Arber,note |
R3750 |
T14748 |
T14747 |
nmod |
et,Arber |
R3751 |
T14654 |
T14652 |
compound |
KO,mice |
R3752 |
T14749 |
T14747 |
nmod |
al.,Arber |
R3753 |
T14750 |
T14747 |
nummod |
2000,Arber |
R3754 |
T14751 |
T14747 |
punct |
),Arber |
R3755 |
T14655 |
T14609 |
punct |
.,report |
R3756 |
T14752 |
T14707 |
punct |
.,is |
R3757 |
T14754 |
T14755 |
nsubj |
Patel,present |
R3758 |
T14657 |
T14658 |
nsubj |
It,is |
R3759 |
T14756 |
T14757 |
advmod |
et,al. |
R3760 |
T14757 |
T14754 |
advmod |
al.,Patel |
R3761 |
T14758 |
T14754 |
punct |
(,Patel |
R3762 |
T14759 |
T14754 |
npadvmod |
2003,Patel |
R3763 |
T14659 |
T14660 |
advmod |
highly,possible |
R3764 |
T14760 |
T14754 |
punct |
),Patel |
R3765 |
T14761 |
T14755 |
advmod |
also,present |
R3766 |
T14762 |
T14755 |
dobj |
observations,present |
R3767 |
T14660 |
T14658 |
acomp |
possible,is |
R3768 |
T14763 |
T14762 |
prep |
from,observations |
R3769 |
T14764 |
T14765 |
compound |
islet2DTA,mice |
R3770 |
T14765 |
T14763 |
pobj |
mice,from |
R3771 |
T14661 |
T14662 |
mark |
that,express |
R3772 |
T14766 |
T14765 |
punct |
", ",mice |
R3773 |
T14767 |
T14768 |
dep |
which,lack |
R3774 |
T14768 |
T14765 |
relcl |
lack,mice |
R3775 |
T14662 |
T14658 |
advcl |
express,is |
R3776 |
T14769 |
T14770 |
det |
a,portion |
R3777 |
T14770 |
T14768 |
dobj |
portion,lack |
R3778 |
T14771 |
T14770 |
amod |
significant,portion |
R3779 |
T14772 |
T14770 |
prep |
of,portion |
R3780 |
T14773 |
T14774 |
det |
the,neurons |
R3781 |
T14774 |
T14772 |
pobj |
neurons,of |
R3782 |
T14663 |
T14664 |
det |
a,number |
R3783 |
T14775 |
T14774 |
compound |
motor,neurons |
R3784 |
T14776 |
T14774 |
prep |
in,neurons |
R3785 |
T14777 |
T14778 |
det |
the,cord |
R3786 |
T14664 |
T14662 |
nsubj |
number,express |
R3787 |
T14778 |
T14776 |
pobj |
cord,in |
R3788 |
T14779 |
T14778 |
amod |
ventral,cord |
R3789 |
T14780 |
T14755 |
punct |
.,present |
R3790 |
T14665 |
T14664 |
amod |
small,number |
R3791 |
T14782 |
T14783 |
prep |
In,shows |
R3792 |
T14666 |
T14665 |
cc |
but,small |
R3793 |
T14784 |
T14785 |
det |
these,mice |
R3794 |
T14785 |
T14782 |
pobj |
mice,In |
R3795 |
T14667 |
T14665 |
conj |
considerable,small |
R3796 |
T14786 |
T14787 |
compound |
PV,immunostaining |
R3797 |
T14787 |
T14783 |
nsubj |
immunostaining,shows |
R3798 |
T14788 |
T14783 |
dobj |
axons,shows |
R3799 |
T14668 |
T14664 |
prep |
of,number |
R3800 |
T14789 |
T14788 |
prep |
in,axons |
R3801 |
T14790 |
T14791 |
det |
the,horns |
R3802 |
T14791 |
T14789 |
pobj |
horns,in |
R3803 |
T14669 |
T14670 |
compound |
DRG,cells |
R3804 |
T14792 |
T14791 |
amod |
ventral,horns |
R3805 |
T14793 |
T14783 |
punct |
.,shows |
R3806 |
T14670 |
T14668 |
pobj |
cells,of |
R3807 |
T14795 |
T14796 |
nsubj |
Patel,argue |
R3808 |
T14671 |
T14672 |
det |
the,factor |
R3809 |
T14672 |
T14662 |
dobj |
factor,express |
R3810 |
T14797 |
T14798 |
advmod |
et,al. |
R3811 |
T14798 |
T14795 |
advmod |
al.,Patel |
R3812 |
T14673 |
T14672 |
compound |
transcription,factor |
R3813 |
T14799 |
T14800 |
mark |
that,be |
R3814 |
T14800 |
T14796 |
ccomp |
be,argue |
R3815 |
T14674 |
T14672 |
appos |
Er81,factor |
R3816 |
T14801 |
T14802 |
mark |
since,are |
R3817 |
T14802 |
T14800 |
advcl |
are,be |
R3818 |
T14803 |
T14804 |
compound |
motor,neurons |
R3819 |
T14675 |
T14662 |
cc |
and,express |
R3820 |
T14804 |
T14802 |
nsubj |
neurons,are |
R3821 |
T14805 |
T14802 |
acomp |
absent,are |
R3822 |
T14806 |
T14802 |
prep |
in,are |
R3823 |
T14676 |
T14677 |
mark |
that,grow |
R3824 |
T14807 |
T14808 |
det |
these,mice |
R3825 |
T14808 |
T14806 |
pobj |
mice,in |
R3826 |
T14677 |
T14662 |
conj |
grow,express |
R3827 |
T14809 |
T14800 |
punct |
", ",be |
R3828 |
T14810 |
T14800 |
nsubj |
NT,be |
R3829 |
T14811 |
T14810 |
punct |
-,NT |
R3830 |
T14812 |
T14810 |
nummod |
3,NT |
R3831 |
T14813 |
T14810 |
acl |
secreted,NT |
R3832 |
T14814 |
T14813 |
prep |
by,secreted |
R3833 |
T14678 |
T14679 |
poss |
their,axons |
R3834 |
T14815 |
T14814 |
pobj |
them,by |
R3835 |
T14816 |
T14800 |
aux |
could,be |
R3836 |
T14817 |
T14800 |
neg |
not,be |
R3837 |
T14679 |
T14677 |
nsubj |
axons,grow |
R3838 |
T14818 |
T14819 |
det |
a,signal |
R3839 |
T14819 |
T14800 |
attr |
signal,be |
R3840 |
T14820 |
T14821 |
mark |
for,enter |
R3841 |
T14680 |
T14677 |
prep |
beyond,grow |
R3842 |
T14821 |
T14819 |
advcl |
enter,signal |
R3843 |
T14822 |
T14823 |
amod |
proprioceptive,axons |
R3844 |
T14823 |
T14821 |
nsubj |
axons,enter |
R3845 |
T14681 |
T14682 |
det |
the,levels |
R3846 |
T14824 |
T14821 |
aux |
to,enter |
R3847 |
T14825 |
T14826 |
det |
the,columns |
R3848 |
T14682 |
T14680 |
pobj |
levels,beyond |
R3849 |
T14826 |
T14821 |
dobj |
columns,enter |
R3850 |
T14827 |
T14826 |
amod |
lateral,columns |
R3851 |
T14828 |
T14826 |
compound |
motor,columns |
R3852 |
T14683 |
T14682 |
amod |
intermediate,levels |
R3853 |
T14829 |
T14796 |
punct |
.,argue |
R3854 |
T14684 |
T14682 |
prep |
of,levels |
R3855 |
T14831 |
T14832 |
advmod |
However,is |
R3856 |
T14833 |
T14832 |
punct |
", ",is |
R3857 |
T14685 |
T14686 |
det |
the,cord |
R3858 |
T14834 |
T14832 |
expl |
there,is |
R3859 |
T14835 |
T14836 |
det |
no,evidence |
R3860 |
T14836 |
T14832 |
attr |
evidence,is |
R3861 |
T14686 |
T14684 |
pobj |
cord,of |
R3862 |
T14837 |
T14836 |
acl |
showing,evidence |
R3863 |
T14838 |
T14839 |
mark |
that,is |
R3864 |
T14687 |
T14686 |
amod |
spinal,cord |
R3865 |
T14839 |
T14837 |
ccomp |
is,showing |
R3866 |
T14840 |
T14841 |
nmod |
NT,mRNA |
R3867 |
T14841 |
T14839 |
nsubj |
mRNA,is |
R3868 |
T14688 |
T14677 |
prep |
in,grow |
R3869 |
T14689 |
T14690 |
nmod |
Bax,KO |
R3870 |
T14690 |
T14696 |
compound |
KO,mice |
R3871 |
T14842 |
T14840 |
punct |
-,NT |
R3872 |
T14843 |
T14840 |
nummod |
3,NT |
R3873 |
T14844 |
T14841 |
cc |
or,mRNA |
R3874 |
T14691 |
T14689 |
punct |
/,Bax |
R3875 |
T14845 |
T14841 |
conj |
protein,mRNA |
R3876 |
T14846 |
T14845 |
acl |
expressed,protein |
R3877 |
T14692 |
T14689 |
appos |
NT,Bax |
R3878 |
T14847 |
T14846 |
prep |
in,expressed |
R3879 |
T14848 |
T14849 |
det |
the,cord |
R3880 |
T14849 |
T14847 |
pobj |
cord,in |
R3881 |
T14693 |
T14692 |
punct |
-,NT |
R3882 |
T14850 |
T14849 |
amod |
ventral,cord |
R3883 |
T14851 |
T14849 |
amod |
spinal,cord |
R3884 |
T14852 |
T14839 |
advmod |
exclusively,is |
R3885 |
T14853 |
T14839 |
prep |
from,is |
R3886 |
T14854 |
T14855 |
compound |
motor,neurons |
R3887 |
T14694 |
T14692 |
nummod |
3,NT |
R3888 |
T14855 |
T14853 |
pobj |
neurons,from |
R3889 |
T14856 |
T14832 |
punct |
", ",is |
R3890 |
T14857 |
T14832 |
cc |
and,is |
R3891 |
T14695 |
T14690 |
amod |
double,KO |
R3892 |
T14858 |
T14859 |
expl |
there,are |
R3893 |
T14859 |
T14832 |
conj |
are,is |
R3894 |
T14696 |
T14688 |
pobj |
mice,in |
R3895 |
T14860 |
T14861 |
det |
no,data |
R3896 |
T14861 |
T14859 |
attr |
data,are |
R3897 |
T14862 |
T14861 |
amod |
available,data |
R3898 |
T14697 |
T14658 |
punct |
.,is |
R3899 |
T14863 |
T14861 |
acl |
indicating,data |
R3900 |
T14864 |
T14865 |
mark |
that,abolished |
R3901 |
T14699 |
T14700 |
mark |
While,is |
R3902 |
T14865 |
T14863 |
ccomp |
abolished,indicating |
R3903 |
T14700 |
T14707 |
advcl |
is,is |
R3904 |
T14866 |
T14865 |
prep |
in,abolished |
R3905 |
T14867 |
T14868 |
compound |
islet2DTA,mice |
R3906 |
T14868 |
T14866 |
pobj |
mice,in |
R3907 |
T14701 |
T14702 |
det |
the,phenotype |
R3908 |
T14869 |
T14865 |
punct |
", ",abolished |
R3909 |
T14870 |
T14871 |
nmod |
NT,expression |
R3910 |
T14871 |
T14865 |
nsubjpass |
expression,abolished |
R3911 |
T14702 |
T14700 |
nsubj |
phenotype,is |
R3912 |
T14872 |
T14870 |
punct |
-,NT |
R3913 |
T14873 |
T14870 |
nummod |
3,NT |
R3914 |
T14703 |
T14702 |
prep |
of,phenotype |
R3915 |
T14874 |
T14871 |
prep |
in,expression |
R3916 |
T14875 |
T14876 |
det |
the,cord |
R3917 |
T14876 |
T14874 |
pobj |
cord,in |
R3918 |
T14704 |
T14705 |
compound |
Er81,KO |
R3919 |
T14877 |
T14876 |
amod |
ventral,cord |
R3920 |
T14878 |
T14876 |
amod |
spinal,cord |
R3921 |
T14879 |
T14865 |
auxpass |
is,abolished |
R3922 |
T14705 |
T14706 |
compound |
KO,mice |
R3923 |
T14880 |
T14881 |
punct |
(,Yang |
R3924 |
T14881 |
T14832 |
meta |
Yang,is |
R3925 |
T14706 |
T14703 |
pobj |
mice,of |
R3926 |
T14708 |
T14709 |
advmod |
quite,dramatic |
R3927 |
T14882 |
T14881 |
nmod |
et,Yang |
R3928 |
T14883 |
T14881 |
nmod |
al.,Yang |
R3929 |
T14884 |
T14881 |
nummod |
2001,Yang |
R3930 |
T14709 |
T14700 |
attr |
dramatic,is |
R3931 |
T14885 |
T14881 |
punct |
;,Yang |
R3932 |
T14886 |
T14881 |
nmod |
Pun,Yang |
R3933 |
T14887 |
T14881 |
nmod |
et,Yang |
R3934 |
T14888 |
T14881 |
nmod |
al.,Yang |
R3935 |
T14889 |
T14881 |
nummod |
2002,Yang |
R3936 |
T14710 |
T14700 |
punct |
", ",is |
R3937 |
T14890 |
T14881 |
punct |
),Yang |
R3938 |
T14891 |
T14832 |
punct |
.,is |
R3939 |
T14711 |
T14700 |
cc |
and,is |
R3940 |
T14893 |
T14894 |
nsubj |
Studies,reported |
R3941 |
T14895 |
T14893 |
prep |
in,Studies |
R3942 |
T14712 |
T14713 |
amod |
most,axons |
R3943 |
T14896 |
T14897 |
amod |
embryonic,mice |
R3944 |
T14897 |
T14895 |
pobj |
mice,in |
R3945 |
T14713 |
T14715 |
nsubj |
axons,stop |
R3946 |
T14898 |
T14899 |
nmod |
NT,mRNA |
R3947 |
T14899 |
T14894 |
dobj |
mRNA,reported |
R3948 |
T14900 |
T14898 |
punct |
-,NT |
R3949 |
T14714 |
T14713 |
amod |
proprioceptive,axons |
R3950 |
T14901 |
T14898 |
nummod |
3,NT |
R3951 |
T14902 |
T14894 |
prep |
in,reported |
R3952 |
T14715 |
T14700 |
conj |
stop,is |
R3953 |
T14903 |
T14904 |
det |
the,horns |
R3954 |
T14904 |
T14902 |
pobj |
horns,in |
R3955 |
T14905 |
T14904 |
amod |
ventral,horns |
R3956 |
T14716 |
T14715 |
prep |
within,stop |
R3957 |
T14906 |
T14904 |
prep |
of,horns |
R3958 |
T14907 |
T14908 |
det |
the,cord |
R3959 |
T14908 |
T14906 |
pobj |
cord,of |
R3960 |
T14717 |
T14718 |
det |
the,cord |
R3961 |
T14909 |
T14908 |
amod |
spinal,cord |
R3962 |
T14910 |
T14894 |
punct |
", ",reported |
R3963 |
T14911 |
T14894 |
cc |
but,reported |
R3964 |
T14718 |
T14716 |
pobj |
cord,within |
R3965 |
T14912 |
T14913 |
nsubj |
it,is |
R3966 |
T14913 |
T14894 |
conj |
is,reported |
R3967 |
T14719 |
T14718 |
amod |
intermediate,cord |
R3971 |
T14720 |
T14718 |
amod |
spinal,cord |
R3972 |
T14917 |
T14913 |
ccomp |
expressed,is |
R3973 |
T14918 |
T14919 |
preconj |
both,mRNA |
R3974 |
T14919 |
T14917 |
nsubjpass |
mRNA,expressed |
R3975 |
T14721 |
T14707 |
punct |
", ",is |
R3976 |
T14920 |
T14919 |
cc |
and,mRNA |
R3977 |
T14921 |
T14919 |
conj |
protein,mRNA |
R3978 |
T14722 |
T14707 |
nsubj |
it,is |
R3979 |
T14922 |
T14917 |
auxpass |
are,expressed |
R3980 |
T14923 |
T14917 |
advmod |
solely,expressed |
R3981 |
T14924 |
T14917 |
agent |
by,expressed |
R3982 |
T14723 |
T14707 |
acomp |
important,is |
R3983 |
T14925 |
T14926 |
compound |
motor,neurons |
R3984 |
T14926 |
T14924 |
pobj |
neurons,by |
R3985 |
T14927 |
T14913 |
punct |
.,is |
R3986 |
T14929 |
T14930 |
prep |
In,express |
R3987 |
T14931 |
T14932 |
det |
the,cord |
R3988 |
T14724 |
T14725 |
aux |
to,note |
R3989 |
T14932 |
T14929 |
pobj |
cord,In |
R3990 |
T14933 |
T14932 |
amod |
adult,cord |
R3991 |
T14934 |
T14932 |
amod |
spinal,cord |
R3992 |
T14725 |
T14707 |
xcomp |
note,is |
R3993 |
T14935 |
T14930 |
punct |
", ",express |
R3994 |
T14936 |
T14937 |
mark |
while,express |
R3995 |
T14937 |
T14930 |
advcl |
express,express |
R3996 |
T14726 |
T14727 |
mark |
that,find |
R3997 |
T14938 |
T14939 |
compound |
motor,neurons |
R3998 |
T14939 |
T14937 |
nsubj |
neurons,express |
R3999 |
T14940 |
T14941 |
amod |
high,levels |
R4000 |
T14727 |
T14725 |
ccomp |
find,note |
R4001 |
T14941 |
T14937 |
dobj |
levels,express |
R4002 |
T14942 |
T14941 |
prep |
of,levels |
R4003 |
T14728 |
T14729 |
det |
a,axons |
R4004 |
T14943 |
T14942 |
pobj |
NT,of |
R4005 |
T14944 |
T14943 |
punct |
-,NT |
R4006 |
T14945 |
T14943 |
nummod |
3,NT |
R4007 |
T14729 |
T14727 |
nsubj |
axons,find |
R4008 |
T14946 |
T14930 |
punct |
", ",express |
R4009 |
T14947 |
T14948 |
amod |
other,cells |
R4010 |
T14730 |
T14729 |
amod |
few,axons |
R4011 |
T14731 |
T14727 |
advmod |
still,find |
R4012 |
T14732 |
T14733 |
poss |
their,way |
R4013 |
T14948 |
T14930 |
nsubj |
cells,express |
R4014 |
T14949 |
T14948 |
punct |
", ",cells |
R4015 |
T14950 |
T14948 |
prep |
including,cells |
R4016 |
T14733 |
T14727 |
dobj |
way,find |
R4017 |
T14951 |
T14950 |
pobj |
glia,including |
R4018 |
T14952 |
T14930 |
punct |
", ",express |
R4019 |
T14734 |
T14727 |
prep |
to,find |
R4020 |
T14953 |
T14930 |
advmod |
also,express |
R4021 |
T14954 |
T14930 |
dobj |
it,express |
R4022 |
T14955 |
T14956 |
punct |
(,Zhou |
R4023 |
T14735 |
T14736 |
det |
the,cord |
R4024 |
T14956 |
T14930 |
meta |
Zhou,express |
R4025 |
T14957 |
T14956 |
cc |
and,Zhou |
R4026 |
T15054 |
T15050 |
pobj |
null,in |
R4027 |
T14958 |
T14956 |
conj |
Rush,Zhou |
R4028 |
T14959 |
T14958 |
nummod |
1994,Rush |
R4029 |
T14960 |
T14958 |
punct |
;,Rush |
R4030 |
T14961 |
T14958 |
conj |
Dreyfus,Rush |
R4031 |
T14962 |
T14961 |
nmod |
et,Dreyfus |
R4032 |
T15055 |
T15050 |
cc |
and,in |
R4033 |
T14963 |
T14961 |
nmod |
al.,Dreyfus |
R4034 |
T15056 |
T15050 |
conj |
in,in |
R4035 |
T15057 |
T15058 |
npadvmod |
p75,null |
R4036 |
T14964 |
T14961 |
nummod |
1999,Dreyfus |
R4037 |
T14965 |
T14961 |
punct |
;,Dreyfus |
R4038 |
T14966 |
T14961 |
conj |
Buck,Dreyfus |
R4039 |
T14967 |
T14966 |
nmod |
et,Buck |
R4040 |
T14968 |
T14966 |
nmod |
al.,Buck |
R4041 |
T14969 |
T14966 |
nummod |
2000,Buck |
R4042 |
T14970 |
T14966 |
punct |
),Buck |
R4043 |
T15058 |
T15056 |
pobj |
null,in |
R4044 |
T14971 |
T14930 |
punct |
.,express |
R4045 |
T14973 |
T14974 |
poss |
Our,results |
R4046 |
T15059 |
T15060 |
compound |
DRG,explants |
R4047 |
T14974 |
T14976 |
nsubj |
results,argue |
R4048 |
T14975 |
T14974 |
amod |
present,results |
R4049 |
T15060 |
T15056 |
pobj |
explants,in |
R4050 |
T14977 |
T14974 |
punct |
", ",results |
R4051 |
T14978 |
T14974 |
cc |
along,results |
R4052 |
T15061 |
T15050 |
punct |
", ",in |
R4053 |
T14979 |
T14978 |
dep |
with,along |
R4054 |
T14980 |
T14974 |
conj |
those,results |
R4055 |
T15062 |
T15050 |
cc |
and,in |
R4056 |
T14981 |
T14980 |
prep |
from,those |
R4057 |
T14982 |
T14983 |
amod |
transgenic,mice |
R4058 |
T14983 |
T14981 |
pobj |
mice,from |
R4059 |
T15063 |
T15050 |
conj |
in,in |
R4060 |
T14984 |
T14983 |
prep |
with,mice |
R4061 |
T14985 |
T14986 |
nmod |
NT,over-expression |
R4062 |
T14986 |
T14984 |
pobj |
over-expression,with |
R4063 |
T15064 |
T15065 |
det |
the,absence |
R4064 |
T14987 |
T14985 |
punct |
-,NT |
R4065 |
T14988 |
T14985 |
nummod |
3,NT |
R4066 |
T14989 |
T14986 |
prep |
in,over-expression |
R4067 |
T15065 |
T15063 |
pobj |
absence,in |
R4068 |
T14990 |
T14991 |
amod |
ectopic,regions |
R4069 |
T14991 |
T14989 |
pobj |
regions,in |
R4070 |
T15066 |
T15065 |
prep |
of,absence |
R4071 |
T14992 |
T14991 |
prep |
of,regions |
R4072 |
T14993 |
T14994 |
det |
the,cord |
R4073 |
T14994 |
T14992 |
pobj |
cord,of |
R4074 |
T15067 |
T15068 |
det |
any,neurotrophins |
R4075 |
T14995 |
T14994 |
amod |
spinal,cord |
R4076 |
T14996 |
T14997 |
punct |
(,Ringstedt |
R4077 |
T14997 |
T14980 |
meta |
Ringstedt,those |
R4078 |
T15068 |
T15066 |
pobj |
neurotrophins,of |
R4079 |
T14998 |
T14997 |
nmod |
et,Ringstedt |
R4080 |
T14999 |
T14997 |
nmod |
al.,Ringstedt |
R4081 |
T15069 |
T15068 |
amod |
other,neurotrophins |
R4082 |
T15000 |
T14997 |
nummod |
1997,Ringstedt |
R4083 |
T15001 |
T14997 |
punct |
),Ringstedt |
R4084 |
T15002 |
T14976 |
punct |
", ",argue |
R4085 |
T15070 |
T15068 |
cc |
or,neurotrophins |
R4086 |
T15003 |
T14976 |
prep |
for,argue |
R4087 |
T15004 |
T15005 |
det |
a,role |
R4088 |
T15005 |
T15003 |
pobj |
role,for |
R4089 |
T15071 |
T15072 |
npadvmod |
target,derived |
R4090 |
T15006 |
T15005 |
prep |
of,role |
R4091 |
T15007 |
T15006 |
pobj |
NT,of |
R4092 |
T15008 |
T15007 |
punct |
-,NT |
R4093 |
T15009 |
T15007 |
nummod |
3,NT |
R4094 |
T15010 |
T15005 |
prep |
in,role |
R4095 |
T15011 |
T15012 |
compound |
chemoattractant,guidance |
R4096 |
T15072 |
T15074 |
amod |
derived,molecules |
R4097 |
T15012 |
T15010 |
pobj |
guidance,in |
R4098 |
T15013 |
T15012 |
compound |
axon,guidance |
R4099 |
T15014 |
T15012 |
prep |
of,guidance |
R4100 |
T15073 |
T15072 |
punct |
-,derived |
R4101 |
T15015 |
T15016 |
amod |
proprioceptive,axons |
R4102 |
T15016 |
T15014 |
pobj |
axons,of |
R4103 |
T15017 |
T15012 |
prep |
in,guidance |
R4104 |
T15074 |
T15068 |
conj |
molecules,neurotrophins |
R4105 |
T15018 |
T15019 |
det |
the,cord |
R4106 |
T15019 |
T15017 |
pobj |
cord,in |
R4107 |
T15075 |
T15076 |
compound |
axon,guidance |
R4108 |
T15020 |
T15019 |
amod |
spinal,cord |
R4109 |
T15021 |
T14976 |
punct |
.,argue |
R4110 |
T15076 |
T15074 |
compound |
guidance,molecules |
R4111 |
T15023 |
T15024 |
advmod |
Finally,see |
R4112 |
T15025 |
T15024 |
punct |
", ",see |
R4113 |
T15077 |
T15048 |
punct |
.,seen |
R4114 |
T15026 |
T15024 |
prep |
in,see |
R4115 |
T15027 |
T15028 |
compound |
culture,assays |
R4116 |
T15028 |
T15026 |
pobj |
assays,in |
R4117 |
T15079 |
T15080 |
advmod |
Furthermore,appear |
R4118 |
T15029 |
T15024 |
punct |
", ",see |
R4119 |
T15030 |
T15024 |
nsubj |
we,see |
R4120 |
T15031 |
T15032 |
det |
a,chemoattraction |
R4121 |
T15032 |
T15024 |
dobj |
chemoattraction,see |
R4122 |
T15081 |
T15080 |
punct |
", ",appear |
R4123 |
T15033 |
T15032 |
amod |
strong,chemoattraction |
R4124 |
T15034 |
T15032 |
prep |
of,chemoattraction |
R4125 |
T15035 |
T15036 |
compound |
DRG,neurons |
R4126 |
T15036 |
T15034 |
pobj |
neurons,of |
R4127 |
T15082 |
T15083 |
advmod |
in,vitro |
R4128 |
T15037 |
T15032 |
prep |
to,chemoattraction |
R4129 |
T15038 |
T15039 |
amod |
localized,sources |
R4130 |
T15039 |
T15037 |
pobj |
sources,to |
R4131 |
T15083 |
T15080 |
advmod |
vitro,appear |
R4132 |
T15040 |
T15039 |
prep |
of,sources |
R4133 |
T15041 |
T15040 |
pobj |
NT,of |
R4134 |
T15084 |
T15080 |
punct |
", ",appear |
R4135 |
T15042 |
T15041 |
punct |
-,NT |
R4136 |
T15043 |
T15041 |
nummod |
3,NT |
R4137 |
T15044 |
T15024 |
punct |
.,see |
R4138 |
T15085 |
T15086 |
amod |
sensory,axon |
R4139 |
T15046 |
T15047 |
det |
This,response |
R4140 |
T15047 |
T15048 |
nsubjpass |
response,seen |
R4141 |
T15086 |
T15087 |
compound |
axon,response |
R4142 |
T15049 |
T15048 |
auxpass |
is,seen |
R4143 |
T15050 |
T15048 |
prep |
in,seen |
R4144 |
T15087 |
T15080 |
nsubj |
response,appear |
R4145 |
T15051 |
T15052 |
nmod |
WT,Bax |
R4146 |
T15052 |
T15054 |
npadvmod |
Bax,null |
R4147 |
T15053 |
T15052 |
punct |
", ",Bax |
R4148 |
T15088 |
T15087 |
prep |
to,response |
R4149 |
T15089 |
T15088 |
pobj |
NT,to |
R4150 |
T15090 |
T15089 |
punct |
-,NT |
R4151 |
T15160 |
T15159 |
amod |
primary,axons |
R4152 |
T15091 |
T15089 |
nummod |
3,NT |
R4153 |
T15161 |
T15159 |
amod |
sensory,axons |
R4154 |
T15162 |
T15147 |
aux |
have,indicated |
R4155 |
T15092 |
T15080 |
aux |
does,appear |
R4156 |
T15163 |
T15164 |
mark |
that,attract |
R4157 |
T15164 |
T15147 |
ccomp |
attract,indicated |
R4158 |
T15093 |
T15080 |
neg |
not,appear |
R4159 |
T15165 |
T15166 |
det |
this,neurotrophin |
R4160 |
T15166 |
T15164 |
nsubj |
neurotrophin,attract |
R4161 |
T15167 |
T15164 |
aux |
can,attract |
R4162 |
T15168 |
T15164 |
cc |
and,attract |
R4163 |
T15094 |
T15095 |
aux |
to,be |
R4164 |
T15169 |
T15164 |
conj |
induce,attract |
R4165 |
T15170 |
T15171 |
amod |
axonal,branching |
R4166 |
T15095 |
T15080 |
xcomp |
be,appear |
R4167 |
T15171 |
T15169 |
dobj |
branching,induce |
R4168 |
T15172 |
T15173 |
punct |
(,Ulupınar |
R4169 |
T15173 |
T15147 |
meta |
Ulupınar,indicated |
R4170 |
T15096 |
T15097 |
npadvmod |
dose,dependent |
R4171 |
T15174 |
T15173 |
nmod |
et,Ulupınar |
R4172 |
T15175 |
T15173 |
nmod |
al.,Ulupınar |
R4173 |
T15176 |
T15173 |
nummod |
2000,Ulupınar |
R4174 |
T15097 |
T15095 |
acomp |
dependent,be |
R4175 |
T15177 |
T15173 |
punct |
;,Ulupınar |
R4176 |
T15178 |
T15173 |
conj |
Özdinler,Ulupınar |
R4177 |
T15179 |
T15178 |
cc |
and,Özdinler |
R4178 |
T15098 |
T15097 |
punct |
-,dependent |
R4179 |
T15180 |
T15178 |
conj |
Erzurumlu,Özdinler |
R4180 |
T15181 |
T15180 |
nummod |
2001,Erzurumlu |
R4181 |
T15182 |
T15180 |
punct |
", ",Erzurumlu |
R4182 |
T15099 |
T15100 |
punct |
(,Ringstedt |
R4183 |
T15183 |
T15180 |
conj |
Özdinler,Erzurumlu |
R4184 |
T15184 |
T15183 |
nmod |
et,Özdinler |
R4185 |
T15185 |
T15183 |
nmod |
al.,Özdinler |
R4186 |
T15100 |
T15080 |
meta |
Ringstedt,appear |
R4187 |
T15186 |
T15183 |
nummod |
2004,Özdinler |
R4188 |
T15187 |
T15183 |
punct |
),Özdinler |
R4189 |
T15188 |
T15147 |
punct |
.,indicated |
R4190 |
T15101 |
T15100 |
nmod |
et,Ringstedt |
R4191 |
T15190 |
T15191 |
prep |
Along,implicated |
R4192 |
T15102 |
T15100 |
nmod |
al.,Ringstedt |
R4193 |
T15192 |
T15193 |
det |
the,pathway |
R4194 |
T15193 |
T15190 |
pobj |
pathway,Along |
R4195 |
T15194 |
T15193 |
amod |
monosynaptic,pathway |
R4196 |
T15195 |
T15196 |
compound |
stretch,reflex |
R4197 |
T15196 |
T15193 |
compound |
reflex,pathway |
R4198 |
T15197 |
T15191 |
punct |
", ",implicated |
R4199 |
T15103 |
T15100 |
nummod |
1997,Ringstedt |
R4200 |
T15198 |
T15199 |
advmod |
only,Wnt |
R4201 |
T15199 |
T15191 |
nsubjpass |
Wnt,implicated |
R4202 |
T15200 |
T15199 |
punct |
-,Wnt |
R4203 |
T15104 |
T15100 |
punct |
;,Ringstedt |
R4204 |
T15201 |
T15199 |
nummod |
3,Wnt |
R4205 |
T15202 |
T15191 |
aux |
has,implicated |
R4206 |
T15203 |
T15191 |
auxpass |
been,implicated |
R4207 |
T15105 |
T15100 |
nmod |
Tucker,Ringstedt |
R4208 |
T15204 |
T15191 |
prep |
as,implicated |
R4209 |
T15205 |
T15206 |
det |
an,factor |
R4210 |
T15206 |
T15204 |
pobj |
factor,as |
R4211 |
T15106 |
T15100 |
nmod |
et,Ringstedt |
R4212 |
T15207 |
T15208 |
compound |
axon,arborization |
R4213 |
T15208 |
T15206 |
compound |
arborization,factor |
R4214 |
T15209 |
T15206 |
prep |
in,factor |
R4215 |
T15107 |
T15100 |
nmod |
al.,Ringstedt |
R4216 |
T15210 |
T15211 |
det |
the,cord |
R4217 |
T15211 |
T15209 |
pobj |
cord,in |
R4218 |
T15108 |
T15100 |
nummod |
2001,Ringstedt |
R4219 |
T15212 |
T15211 |
amod |
spinal,cord |
R4220 |
T15213 |
T15214 |
punct |
(,Krylova |
R4221 |
T15214 |
T15191 |
meta |
Krylova,implicated |
R4222 |
T15109 |
T15100 |
punct |
),Ringstedt |
R4223 |
T15215 |
T15214 |
nmod |
et,Krylova |
R4224 |
T15216 |
T15214 |
nmod |
al.,Krylova |
R4225 |
T15217 |
T15214 |
nummod |
2002,Krylova |
R4226 |
T15110 |
T15080 |
punct |
.,appear |
R4227 |
T15218 |
T15214 |
punct |
),Krylova |
R4228 |
T15219 |
T15191 |
punct |
.,implicated |
R4229 |
T15112 |
T15113 |
nsubj |
NT,is |
R4230 |
T15221 |
T15222 |
det |
Another,molecule |
R4231 |
T15114 |
T15112 |
punct |
-,NT |
R4232 |
T15222 |
T15223 |
nsubj |
molecule,is |
R4233 |
T15115 |
T15112 |
nummod |
3,NT |
R4234 |
T15224 |
T15222 |
punct |
", ",molecule |
R4235 |
T15225 |
T15222 |
appos |
Slit2,molecule |
R4236 |
T15226 |
T15222 |
punct |
", ",molecule |
R4237 |
T15116 |
T15113 |
acomp |
capable,is |
R4238 |
T15227 |
T15222 |
acl |
expressed,molecule |
R4239 |
T15228 |
T15227 |
prep |
in,expressed |
R4240 |
T15229 |
T15230 |
det |
the,midline |
R4241 |
T15117 |
T15116 |
prep |
of,capable |
R4242 |
T15230 |
T15228 |
pobj |
midline,in |
R4243 |
T15231 |
T15228 |
cc |
and,in |
R4244 |
T15118 |
T15117 |
pcomp |
attracting,of |
R4245 |
T15232 |
T15228 |
conj |
by,in |
R4246 |
T15233 |
T15234 |
compound |
motor,neurons |
R4247 |
T15234 |
T15232 |
pobj |
neurons,by |
R4248 |
T15235 |
T15236 |
punct |
(,Wang |
R4249 |
T15236 |
T15227 |
meta |
Wang,expressed |
R4250 |
T15237 |
T15236 |
nmod |
et,Wang |
R4251 |
T15238 |
T15236 |
nmod |
al.,Wang |
R4252 |
T15119 |
T15118 |
dobj |
axons,attracting |
R4253 |
T15239 |
T15236 |
nummod |
1999,Wang |
R4254 |
T15240 |
T15236 |
punct |
),Wang |
R4255 |
T15241 |
T15223 |
acomp |
capable,is |
R4256 |
T15120 |
T15118 |
prep |
along,attracting |
R4257 |
T15242 |
T15241 |
prep |
of,capable |
R4258 |
T15243 |
T15242 |
pcomp |
inducing,of |
R4259 |
T15244 |
T15245 |
amod |
axonal,branching |
R4260 |
T15245 |
T15243 |
dobj |
branching,inducing |
R4261 |
T15121 |
T15120 |
pobj |
distances,along |
R4262 |
T15246 |
T15247 |
punct |
(,Nguyen |
R4263 |
T15247 |
T15223 |
meta |
Nguyen,is |
R4264 |
T15248 |
T15247 |
nmod |
Ba,Nguyen |
R4265 |
T15122 |
T15121 |
prep |
of,distances |
R4266 |
T15249 |
T15247 |
punct |
-,Nguyen |
R4267 |
T15250 |
T15247 |
nmod |
Charvet,Nguyen |
R4268 |
T15123 |
T15124 |
quantmod |
up,1 |
R4269 |
T15251 |
T15247 |
nmod |
et,Nguyen |
R4270 |
T15252 |
T15247 |
nmod |
al.,Nguyen |
R4271 |
T15253 |
T15247 |
nummod |
2001,Nguyen |
R4272 |
T15124 |
T15126 |
nummod |
1,mm |
R4273 |
T15254 |
T15247 |
punct |
;,Nguyen |
R4274 |
T15255 |
T15247 |
conj |
Özdinler,Nguyen |
R4275 |
T15256 |
T15255 |
cc |
and,Özdinler |
R4276 |
T15125 |
T15124 |
quantmod |
to,1 |
R4277 |
T15257 |
T15255 |
conj |
Erzurumlu,Özdinler |
R4278 |
T15258 |
T15257 |
nummod |
2002,Erzurumlu |
R4279 |
T15259 |
T15257 |
punct |
),Erzurumlu |
R4280 |
T15126 |
T15122 |
pobj |
mm,of |
R4281 |
T15260 |
T15223 |
punct |
.,is |
R4282 |
T15127 |
T15118 |
prep |
in,attracting |
R4283 |
T15262 |
T15263 |
compound |
DRG,neurons |
R4284 |
T15263 |
T15264 |
nsubj |
neurons,express |
R4285 |
T15265 |
T15266 |
compound |
Robo,receptors |
R4286 |
T15128 |
T15129 |
compound |
collagen,matrix |
R4287 |
T15129 |
T15127 |
pobj |
matrix,in |
R4288 |
T15130 |
T15129 |
compound |
gel,matrix |
R4289 |
T15131 |
T15113 |
punct |
", ",is |
R4290 |
T15266 |
T15264 |
dobj |
receptors,express |
R4291 |
T15267 |
T15266 |
punct |
", ",receptors |
R4292 |
T15268 |
T15269 |
dep |
which,bind |
R4293 |
T15269 |
T15266 |
relcl |
bind,receptors |
R4294 |
T15132 |
T15113 |
advcl |
covering,is |
R4295 |
T15133 |
T15134 |
det |
the,range |
R4296 |
T15134 |
T15132 |
dobj |
range,covering |
R4297 |
T15135 |
T15134 |
amod |
physiological,range |
R4298 |
T15270 |
T15269 |
prep |
to,bind |
R4299 |
T15271 |
T15270 |
pobj |
Slits,to |
R4300 |
T15272 |
T15264 |
punct |
", ",express |
R4301 |
T15273 |
T15264 |
cc |
and,express |
R4302 |
T15274 |
T15275 |
amod |
proprioceptive,axons |
R4303 |
T15136 |
T15137 |
nsubj |
it,needs |
R4304 |
T15275 |
T15276 |
nsubj |
axons,are |
R4305 |
T15276 |
T15264 |
conj |
are,express |
R4306 |
T15277 |
T15276 |
advmod |
therefore,are |
R4307 |
T15137 |
T15134 |
advcl |
needs,range |
R4308 |
T15278 |
T15276 |
acomp |
capable,are |
R4309 |
T15279 |
T15278 |
prep |
of,capable |
R4310 |
T15280 |
T15279 |
pcomp |
responding,of |
R4311 |
T15138 |
T15139 |
aux |
to,attract |
R4312 |
T15281 |
T15280 |
prep |
to,responding |
R4313 |
T15282 |
T15283 |
compound |
Slit,signals |
R4314 |
T15283 |
T15281 |
pobj |
signals,to |
R4315 |
T15284 |
T15285 |
punct |
(,Wang |
R4316 |
T15139 |
T15137 |
advcl |
attract,needs |
R4317 |
T15285 |
T15276 |
meta |
Wang,are |
R4318 |
T15286 |
T15285 |
nmod |
et,Wang |
R4319 |
T15140 |
T15139 |
dobj |
axons,attract |
R4320 |
T15287 |
T15285 |
nmod |
al.,Wang |
R4321 |
T15288 |
T15285 |
nummod |
1999,Wang |
R4322 |
T15289 |
T15285 |
punct |
),Wang |
R4323 |
T15290 |
T15276 |
punct |
.,are |
R4324 |
T15141 |
T15139 |
prep |
during,attract |
R4326 |
T15142 |
T15141 |
pobj |
development,during |
R4327 |
T15294 |
T15293 |
aux |
does,cause |
R4328 |
T15295 |
T15293 |
neg |
not,cause |
R4329 |
T15296 |
T15293 |
dobj |
repulsion,cause |
R4330 |
T15143 |
T15113 |
punct |
.,is |
R4331 |
T15297 |
T15296 |
prep |
of,repulsion |
R4332 |
T15298 |
T15299 |
npadvmod |
NT,responsive |
R4333 |
T15299 |
T15303 |
amod |
responsive,axons |
R4334 |
T15145 |
T15146 |
amod |
Previous,studies |
R4335 |
T15300 |
T15298 |
punct |
-,NT |
R4336 |
T15301 |
T15298 |
nummod |
3,NT |
R4337 |
T15302 |
T15299 |
punct |
-,responsive |
R4338 |
T15303 |
T15297 |
pobj |
axons,of |
R4339 |
T15146 |
T15147 |
nsubj |
studies,indicated |
R4340 |
T15304 |
T15303 |
compound |
DRG,axons |
R4341 |
T15305 |
T15306 |
advmod |
in,vitro |
R4342 |
T15148 |
T15146 |
prep |
with,studies |
R4343 |
T15306 |
T15293 |
advmod |
vitro,cause |
R4344 |
T15307 |
T15308 |
punct |
(,Nguyen |
R4345 |
T15149 |
T15150 |
amod |
exogenous,applications |
R4346 |
T15308 |
T15293 |
meta |
Nguyen,cause |
R4347 |
T15150 |
T15148 |
pobj |
applications,with |
R4348 |
T15309 |
T15308 |
nmod |
Ba,Nguyen |
R4349 |
T15310 |
T15308 |
punct |
-,Nguyen |
R4350 |
T15311 |
T15308 |
nmod |
Charvet,Nguyen |
R4351 |
T15312 |
T15308 |
nmod |
et,Nguyen |
R4352 |
T15313 |
T15308 |
nmod |
al.,Nguyen |
R4353 |
T15314 |
T15308 |
nummod |
2001,Nguyen |
R4354 |
T15151 |
T15149 |
cc |
or,exogenous |
R4355 |
T15315 |
T15308 |
punct |
),Nguyen |
R4356 |
T15316 |
T15293 |
punct |
", ",cause |
R4357 |
T15152 |
T15149 |
conj |
local,exogenous |
R4358 |
T15317 |
T15293 |
cc |
but,cause |
R4359 |
T15318 |
T15293 |
conj |
causes,cause |
R4360 |
T15153 |
T15150 |
prep |
of,applications |
R4361 |
T15319 |
T15320 |
amod |
ectopic,branching |
R4362 |
T15320 |
T15318 |
dobj |
branching,causes |
R4363 |
T15321 |
T15320 |
cc |
and,branching |
R4364 |
T15154 |
T15153 |
pobj |
NT,of |
R4365 |
T15322 |
T15320 |
conj |
arborization,branching |
R4366 |
T15323 |
T15320 |
prep |
of,branching |
R4367 |
T15324 |
T15325 |
amod |
trigeminal,axons |
R4368 |
T15155 |
T15154 |
punct |
-,NT |
R4369 |
T15325 |
T15323 |
pobj |
axons,of |
R4370 |
T15326 |
T15318 |
prep |
in,causes |
R4371 |
T15327 |
T15328 |
det |
the,brainstem |
R4372 |
T15156 |
T15154 |
nummod |
3,NT |
R4373 |
T15328 |
T15326 |
pobj |
brainstem,in |
R4374 |
T15329 |
T15330 |
punct |
(,Özdinler |
R4375 |
T15157 |
T15150 |
prep |
to,applications |
R4376 |
T15330 |
T15318 |
meta |
Özdinler,causes |
R4377 |
T15331 |
T15330 |
cc |
and,Özdinler |
R4378 |
T15332 |
T15330 |
conj |
Erzurumlu,Özdinler |
R4379 |
T15158 |
T15159 |
amod |
developing,axons |
R4380 |
T15333 |
T15332 |
nummod |
2002,Erzurumlu |
R4381 |
T15334 |
T15332 |
punct |
),Erzurumlu |
R4382 |
T15159 |
T15157 |
pobj |
axons,to |
R4383 |
T15335 |
T15293 |
punct |
.,cause |
R4384 |
T15337 |
T15338 |
advmod |
Thus,involved |
R4385 |
T15372 |
T15373 |
nmod |
Bax,KO |
R4386 |
T15339 |
T15338 |
punct |
", ",involved |
R4387 |
T15340 |
T15338 |
nsubjpass |
Slit2,involved |
R4388 |
T15341 |
T15338 |
aux |
might,involved |
R4389 |
T15373 |
T15378 |
compound |
KO,mice |
R4390 |
T15342 |
T15338 |
advmod |
also,involved |
R4391 |
T15343 |
T15338 |
auxpass |
be,involved |
R4392 |
T15344 |
T15338 |
prep |
in,involved |
R4393 |
T15374 |
T15372 |
punct |
/,Bax |
R4394 |
T15345 |
T15346 |
amod |
terminal,branching |
R4395 |
T15346 |
T15344 |
pobj |
branching,in |
R4396 |
T15347 |
T15346 |
prep |
of,branching |
R4397 |
T15375 |
T15372 |
appos |
NT,Bax |
R4398 |
T15348 |
T15349 |
amod |
propioceptive,axons |
R4399 |
T15349 |
T15347 |
pobj |
axons,of |
R4400 |
T15350 |
T15346 |
prep |
in,branching |
R4401 |
T15376 |
T15375 |
punct |
-,NT |
R4402 |
T15351 |
T15352 |
det |
the,cord |
R4403 |
T15352 |
T15350 |
pobj |
cord,in |
R4404 |
T15353 |
T15352 |
amod |
ventral,cord |
R4405 |
T15354 |
T15344 |
cc |
and,in |
R4406 |
T15355 |
T15344 |
conj |
in,in |
R4407 |
T15356 |
T15357 |
det |
the,branching |
R4408 |
T15377 |
T15375 |
nummod |
3,NT |
R4409 |
T15357 |
T15355 |
pobj |
branching,in |
R4410 |
T15358 |
T15357 |
compound |
midline,branching |
R4411 |
T15359 |
T15357 |
acl |
observed,branching |
R4412 |
T15378 |
T15371 |
pobj |
mice,in |
R4413 |
T15360 |
T15359 |
prep |
in,observed |
R4414 |
T15361 |
T15362 |
poss |
our,KOs |
R4415 |
T15362 |
T15360 |
pobj |
KOs,in |
R4416 |
T15379 |
T15380 |
mark |
that,be |
R4417 |
T15363 |
T15362 |
amod |
double,KOs |
R4418 |
T15364 |
T15338 |
punct |
.,involved |
R4419 |
T15380 |
T15367 |
ccomp |
be,suggests |
R4420 |
T15366 |
T15367 |
nsubj |
Lack,suggests |
R4421 |
T15381 |
T15382 |
compound |
PV,expression |
R4422 |
T15368 |
T15366 |
prep |
of,Lack |
R4423 |
T15369 |
T15370 |
compound |
PV,expression |
R4424 |
T15370 |
T15368 |
pobj |
expression,of |
R4425 |
T15382 |
T15380 |
nsubj |
expression,be |
R4426 |
T15371 |
T15366 |
prep |
in,Lack |
R4427 |
T15383 |
T15380 |
aux |
might,be |
R4428 |
T15384 |
T15380 |
acomp |
responsible,be |
R4429 |
T15478 |
T15476 |
pobj |
expression,of |
R4430 |
T15385 |
T15384 |
prep |
for,responsible |
R4431 |
T15479 |
T15475 |
prep |
in,lack |
R4432 |
T15386 |
T15387 |
amod |
proper,targeting |
R4433 |
T15480 |
T15481 |
amod |
proprioceptive,cells |
R4434 |
T15387 |
T15385 |
pobj |
targeting,for |
R4435 |
T15481 |
T15479 |
pobj |
cells,in |
R4436 |
T15482 |
T15455 |
punct |
.,suggest |
R4437 |
T15388 |
T15387 |
compound |
axon,targeting |
R4438 |
T15389 |
T15387 |
cc |
and,targeting |
R4439 |
T15484 |
T15485 |
poss |
Our,results |
R4440 |
T15485 |
T15487 |
nsubj |
results,suggest |
R4441 |
T15486 |
T15485 |
amod |
present,results |
R4442 |
T15390 |
T15391 |
compound |
muscle,spindle |
R4443 |
T15488 |
T15489 |
mark |
that,acts |
R4444 |
T15391 |
T15392 |
compound |
spindle,differentiation |
R4445 |
T15489 |
T15487 |
ccomp |
acts,suggest |
R4446 |
T15490 |
T15489 |
nsubj |
NT,acts |
R4447 |
T15491 |
T15490 |
punct |
-,NT |
R4448 |
T15392 |
T15387 |
conj |
differentiation,targeting |
R4449 |
T15492 |
T15490 |
nummod |
3,NT |
R4450 |
T15493 |
T15489 |
prep |
as,acts |
R4451 |
T15393 |
T15367 |
punct |
.,suggests |
R4452 |
T15494 |
T15495 |
det |
a,cue |
R4453 |
T15495 |
T15493 |
pobj |
cue,as |
R4454 |
T15496 |
T15497 |
amod |
short,range |
R4455 |
T15497 |
T15495 |
compound |
range,cue |
R4456 |
T15498 |
T15497 |
punct |
-,range |
R4457 |
T15499 |
T15500 |
compound |
axon,guidance |
R4458 |
T15500 |
T15495 |
compound |
guidance,cue |
R4459 |
T15501 |
T15489 |
prep |
for,acts |
R4460 |
T15395 |
T15396 |
advmod |
Presently,rule |
R4461 |
T15502 |
T15503 |
amod |
proprioceptive,axons |
R4462 |
T15503 |
T15501 |
pobj |
axons,for |
R4463 |
T15504 |
T15489 |
advmod |
centrally,acts |
R4464 |
T15505 |
T15504 |
cc |
and,centrally |
R4465 |
T15397 |
T15396 |
nsubj |
we,rule |
R4466 |
T15506 |
T15504 |
conj |
peripherally,centrally |
R4467 |
T15507 |
T15489 |
punct |
", ",acts |
R4468 |
T15508 |
T15509 |
mark |
as,navigate |
R4469 |
T15509 |
T15489 |
advcl |
navigate,acts |
R4470 |
T15398 |
T15396 |
aux |
can,rule |
R4471 |
T15510 |
T15509 |
nsubj |
they,navigate |
R4472 |
T15511 |
T15509 |
prep |
to,navigate |
R4473 |
T15512 |
T15513 |
poss |
their,targets |
R4474 |
T15399 |
T15396 |
neg |
not,rule |
R4475 |
T15513 |
T15511 |
pobj |
targets,to |
R4476 |
T15514 |
T15509 |
advcl |
using,navigate |
R4477 |
T15400 |
T15396 |
advmod |
completely,rule |
R4478 |
T15515 |
T15516 |
amod |
other,cues |
R4479 |
T15516 |
T15514 |
dobj |
cues,using |
R4480 |
T15517 |
T15518 |
compound |
axon,guidance |
R4481 |
T15518 |
T15516 |
compound |
guidance,cues |
R4482 |
T15401 |
T15396 |
prt |
out,rule |
R4483 |
T15519 |
T15487 |
punct |
.,suggest |
R4484 |
T15402 |
T15403 |
det |
this,possibility |
R4485 |
T15521 |
T15522 |
prep |
In,terminate |
R4486 |
T15523 |
T15524 |
poss |
its,absence |
R4487 |
T15403 |
T15396 |
dobj |
possibility,rule |
R4488 |
T15524 |
T15521 |
pobj |
absence,In |
R4489 |
T15525 |
T15522 |
punct |
", ",terminate |
R4490 |
T15526 |
T15527 |
det |
these,axons |
R4491 |
T15404 |
T15396 |
punct |
.,rule |
R4492 |
T15527 |
T15522 |
nsubj |
axons,terminate |
R4493 |
T15528 |
T15522 |
prep |
in,terminate |
R4494 |
T15406 |
T15407 |
advmod |
However,noted |
R4495 |
T15529 |
T15530 |
amod |
inappropriate,loci |
R4496 |
T15530 |
T15528 |
pobj |
loci,in |
R4497 |
T15531 |
T15522 |
punct |
.,terminate |
R4498 |
T15408 |
T15407 |
punct |
", ",noted |
R4499 |
T15533 |
T15534 |
advmod |
However,be |
R4500 |
T15535 |
T15534 |
punct |
", ",be |
R4501 |
T15536 |
T15534 |
nsubj |
NT,be |
R4502 |
T15409 |
T15410 |
det |
no,defects |
R4503 |
T15537 |
T15536 |
punct |
-,NT |
R4504 |
T15538 |
T15536 |
nummod |
3,NT |
R4505 |
T15410 |
T15407 |
nsubjpass |
defects,noted |
R4506 |
T15539 |
T15534 |
aux |
may,be |
R4507 |
T15540 |
T15534 |
neg |
not,be |
R4508 |
T15541 |
T15542 |
det |
the,molecule |
R4509 |
T15542 |
T15534 |
attr |
molecule,be |
R4510 |
T15543 |
T15542 |
amod |
only,molecule |
R4511 |
T15544 |
T15545 |
dep |
that,plays |
R4512 |
T15411 |
T15410 |
prep |
in,defects |
R4513 |
T15545 |
T15542 |
relcl |
plays,molecule |
R4514 |
T15546 |
T15547 |
det |
a,role |
R4515 |
T15547 |
T15545 |
dobj |
role,plays |
R4516 |
T15412 |
T15413 |
compound |
axon,pathfinding |
R4517 |
T15548 |
T15545 |
prep |
in,plays |
R4518 |
T15549 |
T15548 |
pobj |
targeting,in |
R4519 |
T15550 |
T15549 |
cc |
and,targeting |
R4520 |
T15413 |
T15411 |
pobj |
pathfinding,in |
R4521 |
T15551 |
T15552 |
amod |
terminal,branching |
R4522 |
T15552 |
T15549 |
conj |
branching,targeting |
R4523 |
T15414 |
T15410 |
prep |
along,defects |
R4524 |
T15553 |
T15549 |
prep |
of,targeting |
R4525 |
T15554 |
T15555 |
amod |
sensory,axons |
R4526 |
T15555 |
T15553 |
pobj |
axons,of |
R4527 |
T15415 |
T15416 |
det |
the,arc |
R4528 |
T15556 |
T15549 |
prep |
in,targeting |
R4529 |
T15557 |
T15558 |
det |
the,cord |
R4530 |
T15558 |
T15556 |
pobj |
cord,in |
R4531 |
T15416 |
T15414 |
pobj |
arc,along |
R4532 |
T15559 |
T15558 |
amod |
ventral,cord |
R4533 |
T15560 |
T15558 |
amod |
spinal,cord |
R4534 |
T15561 |
T15534 |
punct |
.,be |
R4535 |
T15417 |
T15416 |
amod |
monosynaptic,arc |
R4536 |
T15563 |
T15564 |
nsubj |
NT,acts |
R4537 |
T15418 |
T15416 |
compound |
reflex,arc |
R4538 |
T15565 |
T15563 |
punct |
-,NT |
R4539 |
T15566 |
T15563 |
nummod |
3,NT |
R4540 |
T15419 |
T15414 |
cc |
or,along |
R4541 |
T15567 |
T15568 |
advmod |
most,likely |
R4542 |
T15568 |
T15564 |
advmod |
likely,acts |
R4543 |
T15420 |
T15414 |
conj |
in,along |
R4544 |
T15569 |
T15564 |
advmod |
cooperatively,acts |
R4545 |
T15421 |
T15422 |
compound |
muscle,spindle |
R4546 |
T15570 |
T15564 |
prep |
with,acts |
R4547 |
T15571 |
T15572 |
amod |
other,molecules |
R4548 |
T15572 |
T15570 |
pobj |
molecules,with |
R4549 |
T15422 |
T15423 |
compound |
spindle,differentiation |
R4550 |
T15573 |
T15574 |
compound |
axon,guidance |
R4551 |
T15574 |
T15572 |
compound |
guidance,molecules |
R4552 |
T15575 |
T15570 |
cc |
or,with |
R4553 |
T15423 |
T15420 |
pobj |
differentiation,in |
R4554 |
T15576 |
T15570 |
conj |
by,with |
R4555 |
T15577 |
T15576 |
pcomp |
regulating,by |
R4556 |
T15424 |
T15407 |
aux |
have,noted |
R4557 |
T15578 |
T15577 |
dobj |
expression,regulating |
R4558 |
T15579 |
T15578 |
prep |
of,expression |
R4559 |
T15580 |
T15581 |
advmod |
yet,identified |
R4560 |
T15581 |
T15579 |
pobj |
identified,of |
R4561 |
T15582 |
T15581 |
aux |
to,identified |
R4562 |
T15583 |
T15581 |
auxpass |
be,identified |
R4563 |
T15425 |
T15407 |
auxpass |
been,noted |
R4564 |
T15426 |
T15407 |
prep |
in,noted |
R4565 |
T15584 |
T15585 |
amod |
proprioceptive,neuron |
R4566 |
T15585 |
T15586 |
npadvmod |
neuron,specific |
R4567 |
T15586 |
T15581 |
amod |
specific,identified |
R4568 |
T15427 |
T15428 |
compound |
PV,KO |
R4569 |
T15587 |
T15586 |
punct |
-,specific |
R4570 |
T15588 |
T15589 |
compound |
receptors,ligands |
R4571 |
T15428 |
T15429 |
compound |
KO,mice |
R4572 |
T15589 |
T15581 |
appos |
ligands,identified |
R4573 |
T15590 |
T15589 |
punct |
/,ligands |
R4574 |
T15591 |
T15577 |
prep |
for,regulating |
R4575 |
T15429 |
T15426 |
pobj |
mice,in |
R4576 |
T15592 |
T15593 |
amod |
numerous,cues |
R4577 |
T15593 |
T15591 |
pobj |
cues,for |
R4578 |
T15594 |
T15595 |
compound |
axon,guidance |
R4579 |
T15430 |
T15429 |
punct |
", ",mice |
R4580 |
T15595 |
T15593 |
compound |
guidance,cues |
R4581 |
T15596 |
T15564 |
punct |
.,acts |
R4582 |
T15431 |
T15432 |
dep |
which,develop |
R4583 |
T15432 |
T15429 |
relcl |
develop,mice |
R4584 |
T15433 |
T15432 |
advmod |
normally,develop |
R4585 |
T15434 |
T15432 |
cc |
and,develop |
R4586 |
T15435 |
T15432 |
conj |
show,develop |
R4587 |
T15436 |
T15437 |
det |
no,changes |
R4588 |
T15437 |
T15435 |
dobj |
changes,show |
R4589 |
T15438 |
T15437 |
amod |
apparent,changes |
R4590 |
T15439 |
T15437 |
prep |
in,changes |
R4591 |
T15440 |
T15441 |
poss |
their,behavior |
R4592 |
T15441 |
T15439 |
pobj |
behavior,in |
R4593 |
T15442 |
T15441 |
cc |
or,behavior |
R4594 |
T15443 |
T15444 |
amod |
physical,activity |
R4595 |
T15444 |
T15441 |
conj |
activity,behavior |
R4596 |
T15445 |
T15446 |
punct |
(,Schwaller |
R4597 |
T15446 |
T15407 |
meta |
Schwaller,noted |
R4598 |
T15447 |
T15446 |
nmod |
et,Schwaller |
R4599 |
T15448 |
T15446 |
nmod |
al.,Schwaller |
R4600 |
T15449 |
T15446 |
nummod |
1999,Schwaller |
R4601 |
T15450 |
T15446 |
punct |
),Schwaller |
R4602 |
T15451 |
T15407 |
punct |
.,noted |
R4603 |
T15453 |
T15454 |
det |
These,observations |
R4604 |
T15454 |
T15455 |
nsubj |
observations,suggest |
R4605 |
T15456 |
T15457 |
mark |
that,be |
R4606 |
T15457 |
T15455 |
ccomp |
be,suggest |
R4607 |
T15458 |
T15459 |
amod |
axonal,defects |
R4608 |
T15459 |
T15457 |
nsubj |
defects,be |
R4609 |
T15460 |
T15459 |
amod |
targeting,defects |
R4610 |
T15461 |
T15459 |
prep |
in,defects |
R4611 |
T15462 |
T15463 |
nmod |
Bax,KO |
R4612 |
T15463 |
T15469 |
compound |
KO,mice |
R4613 |
T15464 |
T15462 |
punct |
/,Bax |
R4614 |
T15465 |
T15462 |
appos |
NT,Bax |
R4615 |
T15466 |
T15465 |
punct |
-,NT |
R4616 |
T15467 |
T15465 |
nummod |
3,NT |
R4617 |
T15468 |
T15463 |
amod |
double,KO |
R4618 |
T15469 |
T15461 |
pobj |
mice,in |
R4619 |
T15470 |
T15457 |
aux |
can,be |
R4620 |
T15471 |
T15457 |
neg |
not,be |
R4621 |
T15472 |
T15457 |
advmod |
simply,be |
R4622 |
T15473 |
T15457 |
prep |
due,be |
R4623 |
T15474 |
T15473 |
pcomp |
to,due |
R4624 |
T15475 |
T15473 |
pobj |
lack,due |
R4625 |
T15476 |
T15475 |
prep |
of,lack |
R4626 |
T15477 |
T15478 |
compound |
PV,expression |
R2870 |
T13747 |
T13745 |
pobj |
promoter,by |
R3042 |
T13925 |
T13923 |
ccomp |
is,appears |
R3221 |
T14127 |
T14120 |
aux |
has,noted |
R3222 |
T14128 |
T14120 |
auxpass |
been,noted |
R3224 |
T14130 |
T14131 |
mark |
that,are |
R3599 |
T14523 |
T14486 |
punct |
.,reported |
R3706 |
T14640 |
T14635 |
amod |
double,KO |
R3968 |
T14914 |
T14913 |
neg |
not,is |
R3969 |
T14915 |
T14913 |
acomp |
definitive,is |
R3970 |
T14916 |
T14917 |
mark |
that,expressed |
R4325 |
T15292 |
T15293 |
nsubj |
Slit2,cause |