Id |
Subject |
Object |
Predicate |
Lexical cue |
T10008 |
0-2 |
PRP |
denotes |
It |
T10009 |
3-5 |
VBZ |
denotes |
is |
T10010 |
6-17 |
JJ |
denotes |
interesting |
T10011 |
18-22 |
IN |
denotes |
that |
T10012 |
53-62 |
VBZ |
denotes |
continues |
T10013 |
23-26 |
DT |
denotes |
the |
T10014 |
46-52 |
NN |
denotes |
factor |
T10015 |
27-31 |
NN |
denotes |
SOX9 |
T10016 |
32-45 |
NN |
denotes |
transcription |
T10017 |
63-65 |
TO |
denotes |
to |
T10018 |
69-78 |
VBN |
denotes |
expressed |
T10019 |
66-68 |
VB |
denotes |
be |
T10020 |
79-81 |
IN |
denotes |
in |
T10021 |
82-88 |
NN |
denotes |
mutant |
T10022 |
89-98 |
NN |
denotes |
cartilage |
T10023 |
99-106 |
IN |
denotes |
despite |
T10024 |
107-111 |
NN |
denotes |
loss |
T10025 |
112-114 |
IN |
denotes |
of |
T10026 |
115-121 |
NN |
denotes |
Col2a1 |
T10027 |
121-123 |
, |
denotes |
, |
T10028 |
123-124 |
DT |
denotes |
a |
T10029 |
132-138 |
NN |
denotes |
target |
T10030 |
125-131 |
JJ |
denotes |
direct |
T10031 |
139-141 |
IN |
denotes |
of |
T10032 |
142-146 |
DT |
denotes |
this |
T10033 |
161-167 |
NN |
denotes |
factor |
T10034 |
147-160 |
NN |
denotes |
transcription |
T10035 |
168-169 |
-LRB- |
denotes |
( |
T10036 |
169-173 |
NNP |
denotes |
Bell |
T10037 |
174-176 |
FW |
denotes |
et |
T10038 |
177-180 |
FW |
denotes |
al. |
T10039 |
181-185 |
CD |
denotes |
1997 |
T10040 |
185-186 |
: |
denotes |
; |
T10041 |
187-195 |
NNP |
denotes |
Lefebvre |
T10042 |
196-198 |
FW |
denotes |
et |
T10043 |
199-202 |
FW |
denotes |
al. |
T10044 |
203-207 |
CD |
denotes |
1997 |
T10045 |
207-208 |
-RRB- |
denotes |
) |
T10046 |
208-209 |
. |
denotes |
. |
T10047 |
209-433 |
sentence |
denotes |
Previous studies suggest that SOX9 activity can be modified by protein kinase A (PKA)-dependent protein phosphorylation, or by coexpression of two related proteins, L-SOX5 and SOX6 (Lefebvre et al. 1998; Huang et al. 2000). |
T10048 |
210-218 |
JJ |
denotes |
Previous |
T10049 |
219-226 |
NNS |
denotes |
studies |
T10050 |
227-234 |
VBP |
denotes |
suggest |
T10051 |
235-239 |
IN |
denotes |
that |
T10052 |
261-269 |
VBN |
denotes |
modified |
T10053 |
240-244 |
NN |
denotes |
SOX9 |
T10054 |
245-253 |
NN |
denotes |
activity |
T10055 |
254-257 |
MD |
denotes |
can |
T10056 |
258-260 |
VB |
denotes |
be |
T10057 |
270-272 |
IN |
denotes |
by |
T10058 |
273-280 |
NN |
denotes |
protein |
T10059 |
288-289 |
NN |
denotes |
A |
T10060 |
281-287 |
NN |
denotes |
kinase |
T10061 |
296-305 |
JJ |
denotes |
dependent |
T10062 |
290-291 |
-LRB- |
denotes |
( |
T10063 |
291-294 |
NN |
denotes |
PKA |
T10064 |
294-295 |
-RRB- |
denotes |
) |
T10065 |
295-296 |
HYPH |
denotes |
- |
T10066 |
314-329 |
NN |
denotes |
phosphorylation |
T10067 |
306-313 |
NN |
denotes |
protein |
T10068 |
329-331 |
, |
denotes |
, |
T10069 |
331-333 |
CC |
denotes |
or |
T10070 |
334-336 |
IN |
denotes |
by |
T10071 |
337-349 |
NN |
denotes |
coexpression |
T10072 |
350-352 |
IN |
denotes |
of |
T10073 |
353-356 |
CD |
denotes |
two |
T10074 |
365-373 |
NN |
denotes |
proteins |
T10075 |
357-364 |
VBN |
denotes |
related |
T10076 |
373-375 |
, |
denotes |
, |
T10077 |
375-376 |
NN |
denotes |
L |
T10078 |
377-381 |
NN |
denotes |
SOX5 |
T10079 |
376-377 |
HYPH |
denotes |
- |
T10080 |
382-385 |
CC |
denotes |
and |
T10081 |
386-390 |
NN |
denotes |
SOX6 |
T10082 |
391-392 |
-LRB- |
denotes |
( |
T10083 |
392-400 |
NNP |
denotes |
Lefebvre |
T10084 |
401-403 |
FW |
denotes |
et |
T10085 |
404-407 |
FW |
denotes |
al. |
T10086 |
408-412 |
CD |
denotes |
1998 |
T10087 |
412-413 |
: |
denotes |
; |
T10088 |
414-419 |
NNP |
denotes |
Huang |
T10089 |
420-422 |
FW |
denotes |
et |
T10090 |
423-426 |
FW |
denotes |
al. |
T10091 |
427-431 |
CD |
denotes |
2000 |
T10092 |
431-432 |
-RRB- |
denotes |
) |
T10093 |
432-433 |
. |
denotes |
. |
T10094 |
433-696 |
sentence |
denotes |
In addition, close examination of the order of genes induced during chicken digit formation reveals that Sox9 turns on first, followed by Bmpr1b with L-Sox5, and then Sox6 and the cartilage matrix structural components Col2a1 and Agg (Chimal-Monroy et al. 2003). |
T10095 |
434-436 |
IN |
denotes |
In |
T10096 |
526-533 |
VBZ |
denotes |
reveals |
T10097 |
437-445 |
NN |
denotes |
addition |
T10098 |
445-447 |
, |
denotes |
, |
T10099 |
447-452 |
JJ |
denotes |
close |
T10100 |
453-464 |
NN |
denotes |
examination |
T10101 |
465-467 |
IN |
denotes |
of |
T10102 |
468-471 |
DT |
denotes |
the |
T10103 |
472-477 |
NN |
denotes |
order |
T10104 |
478-480 |
IN |
denotes |
of |
T10105 |
481-486 |
NNS |
denotes |
genes |
T10106 |
487-494 |
VBN |
denotes |
induced |
T10107 |
495-501 |
IN |
denotes |
during |
T10108 |
502-509 |
NN |
denotes |
chicken |
T10109 |
516-525 |
NN |
denotes |
formation |
T10110 |
510-515 |
NN |
denotes |
digit |
T10111 |
534-538 |
IN |
denotes |
that |
T10112 |
544-549 |
VBZ |
denotes |
turns |
T10113 |
539-543 |
NN |
denotes |
Sox9 |
T10114 |
550-552 |
RP |
denotes |
on |
T10115 |
553-558 |
RB |
denotes |
first |
T10116 |
558-560 |
, |
denotes |
, |
T10117 |
560-568 |
VBN |
denotes |
followed |
T10118 |
569-571 |
IN |
denotes |
by |
T10119 |
572-578 |
NN |
denotes |
Bmpr1b |
T10120 |
579-583 |
IN |
denotes |
with |
T10121 |
584-585 |
NN |
denotes |
L |
T10122 |
586-590 |
NN |
denotes |
Sox5 |
T10123 |
585-586 |
HYPH |
denotes |
- |
T10124 |
590-592 |
, |
denotes |
, |
T10125 |
592-595 |
CC |
denotes |
and |
T10126 |
596-600 |
RB |
denotes |
then |
T10127 |
601-605 |
NN |
denotes |
Sox6 |
T10128 |
606-609 |
CC |
denotes |
and |
T10129 |
610-613 |
DT |
denotes |
the |
T10130 |
642-652 |
NNS |
denotes |
components |
T10131 |
614-623 |
NN |
denotes |
cartilage |
T10132 |
624-630 |
NN |
denotes |
matrix |
T10133 |
631-641 |
JJ |
denotes |
structural |
T10134 |
653-659 |
NN |
denotes |
Col2a1 |
T10135 |
660-663 |
CC |
denotes |
and |
T10136 |
664-667 |
NN |
denotes |
Agg |
T10137 |
668-669 |
-LRB- |
denotes |
( |
T10138 |
669-675 |
NNP |
denotes |
Chimal |
T10139 |
675-676 |
HYPH |
denotes |
- |
T10140 |
676-682 |
NNP |
denotes |
Monroy |
T10141 |
683-685 |
FW |
denotes |
et |
T10142 |
686-689 |
FW |
denotes |
al. |
T10143 |
690-694 |
CD |
denotes |
2003 |
T10144 |
694-695 |
-RRB- |
denotes |
) |
T10145 |
695-696 |
. |
denotes |
. |
T10146 |
696-991 |
sentence |
denotes |
These results, together with the altered pattern of gene expression seen in our Bmpr1a-deficient mice, suggest that BMPR1A signaling may normally act to stimulate SOX9 by post-translational protein modification, or to induce L-Sox5 or Sox6 in cartilage to maintain expression of ECM components. |
T10147 |
697-702 |
DT |
denotes |
These |
T10148 |
703-710 |
NNS |
denotes |
results |
T10149 |
800-807 |
VBP |
denotes |
suggest |
T10150 |
710-712 |
, |
denotes |
, |
T10151 |
712-720 |
RB |
denotes |
together |
T10152 |
721-725 |
IN |
denotes |
with |
T10153 |
726-729 |
DT |
denotes |
the |
T10154 |
738-745 |
NN |
denotes |
pattern |
T10155 |
730-737 |
VBN |
denotes |
altered |
T10156 |
746-748 |
IN |
denotes |
of |
T10157 |
749-753 |
NN |
denotes |
gene |
T10158 |
754-764 |
NN |
denotes |
expression |
T10159 |
765-769 |
VBN |
denotes |
seen |
T10160 |
770-772 |
IN |
denotes |
in |
T10161 |
773-776 |
PRP$ |
denotes |
our |
T10162 |
794-798 |
NNS |
denotes |
mice |
T10163 |
777-783 |
NN |
denotes |
Bmpr1a |
T10164 |
784-793 |
JJ |
denotes |
deficient |
T10165 |
783-784 |
HYPH |
denotes |
- |
T10166 |
798-800 |
, |
denotes |
, |
T10167 |
808-812 |
IN |
denotes |
that |
T10168 |
843-846 |
VB |
denotes |
act |
T10169 |
813-819 |
NN |
denotes |
BMPR1A |
T10170 |
820-829 |
NN |
denotes |
signaling |
T10171 |
830-833 |
MD |
denotes |
may |
T10172 |
834-842 |
RB |
denotes |
normally |
T10173 |
847-849 |
TO |
denotes |
to |
T10174 |
850-859 |
VB |
denotes |
stimulate |
T10175 |
860-864 |
NN |
denotes |
SOX9 |
T10176 |
865-867 |
IN |
denotes |
by |
T10177 |
868-886 |
JJ |
denotes |
post-translational |
T10178 |
895-907 |
NN |
denotes |
modification |
T10179 |
887-894 |
NN |
denotes |
protein |
T10180 |
907-909 |
, |
denotes |
, |
T10181 |
909-911 |
CC |
denotes |
or |
T10182 |
912-914 |
TO |
denotes |
to |
T10183 |
915-921 |
VB |
denotes |
induce |
T10184 |
922-923 |
NN |
denotes |
L |
T10185 |
924-928 |
NN |
denotes |
Sox5 |
T10186 |
923-924 |
HYPH |
denotes |
- |
T10187 |
929-931 |
CC |
denotes |
or |
T10188 |
932-936 |
NN |
denotes |
Sox6 |
T10189 |
937-939 |
IN |
denotes |
in |
T10190 |
940-949 |
NN |
denotes |
cartilage |
T10191 |
950-952 |
TO |
denotes |
to |
T10192 |
953-961 |
VB |
denotes |
maintain |
T10193 |
962-972 |
NN |
denotes |
expression |
T10194 |
973-975 |
IN |
denotes |
of |
T10195 |
976-979 |
NN |
denotes |
ECM |
T10196 |
980-990 |
NNS |
denotes |
components |
T10197 |
990-991 |
. |
denotes |
. |
T10198 |
991-1181 |
sentence |
denotes |
These models are consistent with the ability of BMP2 to both increase PKA activity and induce expression of Sox6 in tissue culture cells (Lee and Chuong 1997; Fernandez-Lloris et al. 2003). |
T10199 |
992-997 |
DT |
denotes |
These |
T10200 |
998-1004 |
NNS |
denotes |
models |
T10201 |
1005-1008 |
VBP |
denotes |
are |
T10202 |
1009-1019 |
JJ |
denotes |
consistent |
T10203 |
1020-1024 |
IN |
denotes |
with |
T10204 |
1025-1028 |
DT |
denotes |
the |
T10205 |
1029-1036 |
NN |
denotes |
ability |
T10206 |
1037-1039 |
IN |
denotes |
of |
T10207 |
1040-1044 |
NN |
denotes |
BMP2 |
T10208 |
1045-1047 |
TO |
denotes |
to |
T10209 |
1053-1061 |
VB |
denotes |
increase |
T10210 |
1048-1052 |
CC |
denotes |
both |
T10211 |
1062-1065 |
NN |
denotes |
PKA |
T10212 |
1066-1074 |
NN |
denotes |
activity |
T10213 |
1075-1078 |
CC |
denotes |
and |
T10214 |
1079-1085 |
VB |
denotes |
induce |
T10215 |
1086-1096 |
NN |
denotes |
expression |
T10216 |
1097-1099 |
IN |
denotes |
of |
T10217 |
1100-1104 |
NN |
denotes |
Sox6 |
T10218 |
1105-1107 |
IN |
denotes |
in |
T10219 |
1108-1114 |
NN |
denotes |
tissue |
T10220 |
1123-1128 |
NNS |
denotes |
cells |
T10221 |
1115-1122 |
NN |
denotes |
culture |
T10222 |
1129-1130 |
-LRB- |
denotes |
( |
T10223 |
1130-1133 |
NNP |
denotes |
Lee |
T10224 |
1134-1137 |
CC |
denotes |
and |
T10225 |
1138-1144 |
NNP |
denotes |
Chuong |
T10226 |
1145-1149 |
CD |
denotes |
1997 |
T10227 |
1149-1150 |
: |
denotes |
; |
T10228 |
1151-1160 |
NNP |
denotes |
Fernandez |
T10229 |
1160-1161 |
HYPH |
denotes |
- |
T10230 |
1161-1167 |
NNP |
denotes |
Lloris |
T10231 |
1168-1170 |
FW |
denotes |
et |
T10232 |
1171-1174 |
FW |
denotes |
al. |
T10233 |
1175-1179 |
CD |
denotes |
2003 |
T10234 |
1179-1180 |
-RRB- |
denotes |
) |
T10235 |
1180-1181 |
. |
denotes |
. |
T10236 |
1181-1508 |
sentence |
denotes |
Although we have tried to monitor the expression of L-Sox5 or Sox6 in postnatal articular cartilage, and test the phosphorylation state of SOX9 using previously described reagents (Lefebvre et al. 1998; Huang et al. 2000), we have been unable to obtain specific signal at the late postnatal stages required (unpublished data). |
T10237 |
1182-1190 |
IN |
denotes |
Although |
T10238 |
1199-1204 |
VBN |
denotes |
tried |
T10239 |
1191-1193 |
PRP |
denotes |
we |
T10240 |
1194-1198 |
VBP |
denotes |
have |
T10241 |
1413-1417 |
VBN |
denotes |
been |
T10242 |
1205-1207 |
TO |
denotes |
to |
T10243 |
1208-1215 |
VB |
denotes |
monitor |
T10244 |
1216-1219 |
DT |
denotes |
the |
T10245 |
1220-1230 |
NN |
denotes |
expression |
T10246 |
1231-1233 |
IN |
denotes |
of |
T10247 |
1234-1235 |
NN |
denotes |
L |
T10248 |
1236-1240 |
NN |
denotes |
Sox5 |
T10249 |
1235-1236 |
HYPH |
denotes |
- |
T10250 |
1241-1243 |
CC |
denotes |
or |
T10251 |
1244-1248 |
NN |
denotes |
Sox6 |
T10252 |
1249-1251 |
IN |
denotes |
in |
T10253 |
1252-1261 |
JJ |
denotes |
postnatal |
T10254 |
1272-1281 |
NN |
denotes |
cartilage |
T10255 |
1262-1271 |
JJ |
denotes |
articular |
T10256 |
1281-1283 |
, |
denotes |
, |
T10257 |
1283-1286 |
CC |
denotes |
and |
T10258 |
1287-1291 |
VB |
denotes |
test |
T10259 |
1292-1295 |
DT |
denotes |
the |
T10260 |
1312-1317 |
NN |
denotes |
state |
T10261 |
1296-1311 |
NN |
denotes |
phosphorylation |
T10262 |
1318-1320 |
IN |
denotes |
of |
T10263 |
1321-1325 |
NN |
denotes |
SOX9 |
T10264 |
1326-1331 |
VBG |
denotes |
using |
T10265 |
1332-1342 |
RB |
denotes |
previously |
T10266 |
1343-1352 |
VBN |
denotes |
described |
T10267 |
1353-1361 |
NNS |
denotes |
reagents |
T10268 |
1362-1363 |
-LRB- |
denotes |
( |
T10269 |
1363-1371 |
NNP |
denotes |
Lefebvre |
T10270 |
1372-1374 |
FW |
denotes |
et |
T10271 |
1375-1378 |
FW |
denotes |
al. |
T10272 |
1379-1383 |
CD |
denotes |
1998 |
T10273 |
1383-1384 |
: |
denotes |
; |
T10274 |
1385-1390 |
NNP |
denotes |
Huang |
T10275 |
1391-1393 |
FW |
denotes |
et |
T10276 |
1394-1397 |
FW |
denotes |
al. |
T10277 |
1398-1402 |
CD |
denotes |
2000 |
T10278 |
1402-1403 |
-RRB- |
denotes |
) |
T10279 |
1403-1405 |
, |
denotes |
, |
T10280 |
1405-1407 |
PRP |
denotes |
we |
T10281 |
1408-1412 |
VBP |
denotes |
have |
T10282 |
1418-1424 |
JJ |
denotes |
unable |
T10283 |
1425-1427 |
TO |
denotes |
to |
T10284 |
1428-1434 |
VB |
denotes |
obtain |
T10285 |
1435-1443 |
JJ |
denotes |
specific |
T10286 |
1444-1450 |
NN |
denotes |
signal |
T10287 |
1451-1453 |
IN |
denotes |
at |
T10288 |
1454-1457 |
DT |
denotes |
the |
T10289 |
1473-1479 |
NNS |
denotes |
stages |
T10290 |
1458-1462 |
JJ |
denotes |
late |
T10291 |
1463-1472 |
JJ |
denotes |
postnatal |
T10292 |
1480-1488 |
VBN |
denotes |
required |
T10293 |
1489-1490 |
-LRB- |
denotes |
( |
T10294 |
1502-1506 |
NNS |
denotes |
data |
T10295 |
1490-1501 |
JJ |
denotes |
unpublished |
T10296 |
1506-1507 |
-RRB- |
denotes |
) |
T10297 |
1507-1508 |
. |
denotes |
. |
T10298 |
1508-1673 |
sentence |
denotes |
Furthermore, null mutations in L-Sox5 or Sox-6 cause lethality at or soon after birth, and no effect on cartilage maintenance has been reported (Smits et al. 2001). |
T10299 |
1509-1520 |
RB |
denotes |
Furthermore |
T10300 |
1556-1561 |
VBP |
denotes |
cause |
T10301 |
1520-1522 |
, |
denotes |
, |
T10302 |
1522-1526 |
JJ |
denotes |
null |
T10303 |
1527-1536 |
NNS |
denotes |
mutations |
T10304 |
1537-1539 |
IN |
denotes |
in |
T10305 |
1540-1541 |
NN |
denotes |
L |
T10306 |
1542-1546 |
NN |
denotes |
Sox5 |
T10307 |
1541-1542 |
HYPH |
denotes |
- |
T10308 |
1547-1549 |
CC |
denotes |
or |
T10309 |
1550-1553 |
NN |
denotes |
Sox |
T10310 |
1553-1554 |
HYPH |
denotes |
- |
T10311 |
1554-1555 |
CD |
denotes |
6 |
T10312 |
1562-1571 |
NN |
denotes |
lethality |
T10313 |
1572-1574 |
IN |
denotes |
at |
T10314 |
1575-1577 |
CC |
denotes |
or |
T10315 |
1578-1582 |
RB |
denotes |
soon |
T10316 |
1583-1588 |
IN |
denotes |
after |
T10317 |
1589-1594 |
NN |
denotes |
birth |
T10318 |
1594-1596 |
, |
denotes |
, |
T10319 |
1596-1599 |
CC |
denotes |
and |
T10320 |
1600-1602 |
DT |
denotes |
no |
T10321 |
1603-1609 |
NN |
denotes |
effect |
T10322 |
1644-1652 |
VBN |
denotes |
reported |
T10323 |
1610-1612 |
IN |
denotes |
on |
T10324 |
1613-1622 |
NN |
denotes |
cartilage |
T10325 |
1623-1634 |
NN |
denotes |
maintenance |
T10326 |
1635-1638 |
VBZ |
denotes |
has |
T10327 |
1639-1643 |
VBN |
denotes |
been |
T10328 |
1653-1654 |
-LRB- |
denotes |
( |
T10329 |
1654-1659 |
NNP |
denotes |
Smits |
T10330 |
1660-1662 |
FW |
denotes |
et |
T10331 |
1663-1666 |
FW |
denotes |
al. |
T10332 |
1667-1671 |
CD |
denotes |
2001 |
T10333 |
1671-1672 |
-RRB- |
denotes |
) |
T10334 |
1672-1673 |
. |
denotes |
. |
T10335 |
1673-1822 |
sentence |
denotes |
However, it seems likely that these or other processes regulated by BMP signaling cooperate with SOX9 to induce target genes in articular cartilage. |
T10336 |
1674-1681 |
RB |
denotes |
However |
T10337 |
1686-1691 |
VBZ |
denotes |
seems |
T10338 |
1681-1683 |
, |
denotes |
, |
T10339 |
1683-1685 |
PRP |
denotes |
it |
T10340 |
1692-1698 |
JJ |
denotes |
likely |
T10341 |
1699-1703 |
IN |
denotes |
that |
T10342 |
1756-1765 |
VBP |
denotes |
cooperate |
T10343 |
1704-1709 |
DT |
denotes |
these |
T10344 |
1710-1712 |
CC |
denotes |
or |
T10345 |
1713-1718 |
JJ |
denotes |
other |
T10346 |
1719-1728 |
NNS |
denotes |
processes |
T10347 |
1729-1738 |
VBN |
denotes |
regulated |
T10348 |
1739-1741 |
IN |
denotes |
by |
T10349 |
1742-1745 |
NN |
denotes |
BMP |
T10350 |
1746-1755 |
NN |
denotes |
signaling |
T10351 |
1766-1770 |
IN |
denotes |
with |
T10352 |
1771-1775 |
NN |
denotes |
SOX9 |
T10353 |
1776-1778 |
TO |
denotes |
to |
T10354 |
1779-1785 |
VB |
denotes |
induce |
T10355 |
1786-1792 |
JJ |
denotes |
target |
T10356 |
1793-1798 |
NNS |
denotes |
genes |
T10357 |
1799-1801 |
IN |
denotes |
in |
T10358 |
1802-1811 |
JJ |
denotes |
articular |
T10359 |
1812-1821 |
NN |
denotes |
cartilage |
T10360 |
1821-1822 |
. |
denotes |
. |
R6272 |
T10008 |
T10009 |
nsubj |
It,is |
R6273 |
T10010 |
T10009 |
acomp |
interesting,is |
R6274 |
T10011 |
T10012 |
mark |
that,continues |
R6275 |
T10012 |
T10009 |
ccomp |
continues,is |
R6276 |
T10013 |
T10014 |
det |
the,factor |
R6277 |
T10014 |
T10012 |
nsubj |
factor,continues |
R6278 |
T10015 |
T10016 |
compound |
SOX9,transcription |
R6279 |
T10016 |
T10014 |
compound |
transcription,factor |
R6280 |
T10017 |
T10018 |
aux |
to,expressed |
R6281 |
T10018 |
T10012 |
xcomp |
expressed,continues |
R6282 |
T10019 |
T10018 |
auxpass |
be,expressed |
R6283 |
T10020 |
T10018 |
prep |
in,expressed |
R6284 |
T10021 |
T10022 |
compound |
mutant,cartilage |
R6285 |
T10022 |
T10020 |
pobj |
cartilage,in |
R6286 |
T10023 |
T10018 |
prep |
despite,expressed |
R6287 |
T10024 |
T10023 |
pobj |
loss,despite |
R6288 |
T10025 |
T10024 |
prep |
of,loss |
R6289 |
T10026 |
T10025 |
pobj |
Col2a1,of |
R6290 |
T10027 |
T10026 |
punct |
", ",Col2a1 |
R6291 |
T10028 |
T10029 |
det |
a,target |
R6292 |
T10029 |
T10026 |
appos |
target,Col2a1 |
R6293 |
T10030 |
T10029 |
amod |
direct,target |
R6294 |
T10031 |
T10029 |
prep |
of,target |
R6295 |
T10032 |
T10033 |
det |
this,factor |
R6296 |
T10033 |
T10031 |
pobj |
factor,of |
R6297 |
T10034 |
T10033 |
compound |
transcription,factor |
R6298 |
T10035 |
T10036 |
punct |
(,Bell |
R6299 |
T10036 |
T10009 |
meta |
Bell,is |
R6300 |
T10037 |
T10036 |
nmod |
et,Bell |
R6301 |
T10038 |
T10036 |
nmod |
al.,Bell |
R6302 |
T10039 |
T10036 |
nummod |
1997,Bell |
R6303 |
T10040 |
T10036 |
punct |
;,Bell |
R6304 |
T10041 |
T10036 |
nmod |
Lefebvre,Bell |
R6305 |
T10042 |
T10036 |
nmod |
et,Bell |
R6306 |
T10043 |
T10036 |
nmod |
al.,Bell |
R6307 |
T10044 |
T10036 |
nummod |
1997,Bell |
R6308 |
T10045 |
T10036 |
punct |
),Bell |
R6309 |
T10046 |
T10009 |
punct |
.,is |
R6310 |
T10048 |
T10049 |
amod |
Previous,studies |
R6311 |
T10049 |
T10050 |
nsubj |
studies,suggest |
R6312 |
T10051 |
T10052 |
mark |
that,modified |
R6313 |
T10052 |
T10050 |
ccomp |
modified,suggest |
R6314 |
T10053 |
T10054 |
compound |
SOX9,activity |
R6315 |
T10054 |
T10052 |
nsubjpass |
activity,modified |
R6316 |
T10055 |
T10052 |
aux |
can,modified |
R6317 |
T10056 |
T10052 |
auxpass |
be,modified |
R6318 |
T10057 |
T10052 |
prep |
by,modified |
R6319 |
T10058 |
T10059 |
compound |
protein,A |
R6320 |
T10059 |
T10061 |
npadvmod |
A,dependent |
R6321 |
T10060 |
T10059 |
compound |
kinase,A |
R6322 |
T10061 |
T10066 |
amod |
dependent,phosphorylation |
R6323 |
T10062 |
T10059 |
punct |
(,A |
R6324 |
T10063 |
T10059 |
appos |
PKA,A |
R6325 |
T10064 |
T10059 |
punct |
),A |
R6326 |
T10065 |
T10061 |
punct |
-,dependent |
R6327 |
T10066 |
T10057 |
pobj |
phosphorylation,by |
R6328 |
T10067 |
T10066 |
compound |
protein,phosphorylation |
R6329 |
T10068 |
T10057 |
punct |
", ",by |
R6330 |
T10069 |
T10057 |
cc |
or,by |
R6331 |
T10070 |
T10057 |
conj |
by,by |
R6332 |
T10071 |
T10070 |
pobj |
coexpression,by |
R6333 |
T10072 |
T10071 |
prep |
of,coexpression |
R6334 |
T10073 |
T10074 |
nummod |
two,proteins |
R6335 |
T10074 |
T10072 |
pobj |
proteins,of |
R6336 |
T10075 |
T10074 |
amod |
related,proteins |
R6337 |
T10076 |
T10074 |
punct |
", ",proteins |
R6338 |
T10077 |
T10078 |
compound |
L,SOX5 |
R6339 |
T10078 |
T10074 |
appos |
SOX5,proteins |
R6340 |
T10079 |
T10078 |
punct |
-,SOX5 |
R6341 |
T10080 |
T10078 |
cc |
and,SOX5 |
R6342 |
T10081 |
T10078 |
conj |
SOX6,SOX5 |
R6343 |
T10082 |
T10083 |
punct |
(,Lefebvre |
R6344 |
T10083 |
T10050 |
meta |
Lefebvre,suggest |
R6345 |
T10084 |
T10083 |
nmod |
et,Lefebvre |
R6346 |
T10085 |
T10083 |
nmod |
al.,Lefebvre |
R6347 |
T10086 |
T10083 |
nummod |
1998,Lefebvre |
R6348 |
T10087 |
T10083 |
punct |
;,Lefebvre |
R6349 |
T10088 |
T10083 |
nmod |
Huang,Lefebvre |
R6350 |
T10089 |
T10083 |
nmod |
et,Lefebvre |
R6351 |
T10090 |
T10083 |
nmod |
al.,Lefebvre |
R6352 |
T10091 |
T10083 |
nummod |
2000,Lefebvre |
R6353 |
T10092 |
T10083 |
punct |
),Lefebvre |
R6354 |
T10093 |
T10050 |
punct |
.,suggest |
R6355 |
T10095 |
T10096 |
prep |
In,reveals |
R6356 |
T10097 |
T10095 |
pobj |
addition,In |
R6357 |
T10098 |
T10096 |
punct |
", ",reveals |
R6358 |
T10099 |
T10100 |
amod |
close,examination |
R6359 |
T10100 |
T10096 |
nsubj |
examination,reveals |
R6360 |
T10101 |
T10100 |
prep |
of,examination |
R6361 |
T10102 |
T10103 |
det |
the,order |
R6362 |
T10103 |
T10101 |
pobj |
order,of |
R6363 |
T10104 |
T10103 |
prep |
of,order |
R6364 |
T10105 |
T10104 |
pobj |
genes,of |
R6365 |
T10106 |
T10105 |
acl |
induced,genes |
R6366 |
T10107 |
T10106 |
prep |
during,induced |
R6367 |
T10108 |
T10109 |
compound |
chicken,formation |
R6368 |
T10109 |
T10107 |
pobj |
formation,during |
R6369 |
T10110 |
T10109 |
compound |
digit,formation |
R6370 |
T10111 |
T10112 |
mark |
that,turns |
R6371 |
T10112 |
T10096 |
ccomp |
turns,reveals |
R6372 |
T10113 |
T10112 |
nsubj |
Sox9,turns |
R6373 |
T10114 |
T10112 |
prt |
on,turns |
R6374 |
T10115 |
T10112 |
advmod |
first,turns |
R6375 |
T10116 |
T10112 |
punct |
", ",turns |
R6376 |
T10117 |
T10112 |
advcl |
followed,turns |
R6377 |
T10118 |
T10117 |
agent |
by,followed |
R6378 |
T10119 |
T10118 |
pobj |
Bmpr1b,by |
R6379 |
T10120 |
T10119 |
prep |
with,Bmpr1b |
R6380 |
T10121 |
T10122 |
compound |
L,Sox5 |
R6381 |
T10122 |
T10120 |
pobj |
Sox5,with |
R6382 |
T10123 |
T10122 |
punct |
-,Sox5 |
R6383 |
T10124 |
T10119 |
punct |
", ",Bmpr1b |
R6384 |
T10125 |
T10119 |
cc |
and,Bmpr1b |
R6385 |
T10126 |
T10127 |
advmod |
then,Sox6 |
R6386 |
T10127 |
T10119 |
conj |
Sox6,Bmpr1b |
R6387 |
T10128 |
T10127 |
cc |
and,Sox6 |
R6388 |
T10129 |
T10130 |
det |
the,components |
R6389 |
T10130 |
T10127 |
conj |
components,Sox6 |
R6390 |
T10131 |
T10132 |
nmod |
cartilage,matrix |
R6391 |
T10132 |
T10130 |
nmod |
matrix,components |
R6392 |
T10133 |
T10130 |
amod |
structural,components |
R6393 |
T10134 |
T10130 |
appos |
Col2a1,components |
R6394 |
T10135 |
T10134 |
cc |
and,Col2a1 |
R6395 |
T10136 |
T10134 |
conj |
Agg,Col2a1 |
R6396 |
T10137 |
T10138 |
punct |
(,Chimal |
R6397 |
T10138 |
T10096 |
meta |
Chimal,reveals |
R6398 |
T10139 |
T10138 |
punct |
-,Chimal |
R6399 |
T10140 |
T10138 |
nmod |
Monroy,Chimal |
R6400 |
T10141 |
T10138 |
nmod |
et,Chimal |
R6401 |
T10142 |
T10138 |
nmod |
al.,Chimal |
R6402 |
T10143 |
T10138 |
nummod |
2003,Chimal |
R6403 |
T10144 |
T10138 |
punct |
),Chimal |
R6404 |
T10145 |
T10096 |
punct |
.,reveals |
R6405 |
T10147 |
T10148 |
det |
These,results |
R6406 |
T10148 |
T10149 |
nsubj |
results,suggest |
R6407 |
T10150 |
T10148 |
punct |
", ",results |
R6408 |
T10151 |
T10148 |
advmod |
together,results |
R6409 |
T10152 |
T10151 |
prep |
with,together |
R6410 |
T10153 |
T10154 |
det |
the,pattern |
R6411 |
T10154 |
T10152 |
pobj |
pattern,with |
R6412 |
T10155 |
T10154 |
amod |
altered,pattern |
R6413 |
T10156 |
T10154 |
prep |
of,pattern |
R6414 |
T10157 |
T10158 |
compound |
gene,expression |
R6415 |
T10158 |
T10156 |
pobj |
expression,of |
R6416 |
T10159 |
T10154 |
acl |
seen,pattern |
R6417 |
T10160 |
T10159 |
prep |
in,seen |
R6418 |
T10161 |
T10162 |
poss |
our,mice |
R6419 |
T10162 |
T10160 |
pobj |
mice,in |
R6420 |
T10163 |
T10164 |
npadvmod |
Bmpr1a,deficient |
R6421 |
T10164 |
T10162 |
amod |
deficient,mice |
R6422 |
T10165 |
T10164 |
punct |
-,deficient |
R6423 |
T10166 |
T10149 |
punct |
", ",suggest |
R6424 |
T10167 |
T10168 |
mark |
that,act |
R6425 |
T10168 |
T10149 |
ccomp |
act,suggest |
R6426 |
T10169 |
T10170 |
compound |
BMPR1A,signaling |
R6427 |
T10170 |
T10168 |
nsubj |
signaling,act |
R6428 |
T10171 |
T10168 |
aux |
may,act |
R6429 |
T10172 |
T10168 |
advmod |
normally,act |
R6430 |
T10173 |
T10174 |
aux |
to,stimulate |
R6431 |
T10174 |
T10168 |
xcomp |
stimulate,act |
R6432 |
T10175 |
T10174 |
dobj |
SOX9,stimulate |
R6433 |
T10176 |
T10174 |
prep |
by,stimulate |
R6434 |
T10177 |
T10178 |
amod |
post-translational,modification |
R6435 |
T10178 |
T10176 |
pobj |
modification,by |
R6436 |
T10179 |
T10178 |
compound |
protein,modification |
R6437 |
T10180 |
T10174 |
punct |
", ",stimulate |
R6438 |
T10181 |
T10174 |
cc |
or,stimulate |
R6439 |
T10182 |
T10183 |
aux |
to,induce |
R6440 |
T10183 |
T10174 |
conj |
induce,stimulate |
R6441 |
T10184 |
T10185 |
compound |
L,Sox5 |
R6442 |
T10185 |
T10183 |
dobj |
Sox5,induce |
R6443 |
T10186 |
T10185 |
punct |
-,Sox5 |
R6444 |
T10187 |
T10185 |
cc |
or,Sox5 |
R6445 |
T10188 |
T10185 |
conj |
Sox6,Sox5 |
R6446 |
T10189 |
T10183 |
prep |
in,induce |
R6447 |
T10190 |
T10189 |
pobj |
cartilage,in |
R6448 |
T10191 |
T10192 |
aux |
to,maintain |
R6449 |
T10192 |
T10183 |
advcl |
maintain,induce |
R6450 |
T10193 |
T10192 |
dobj |
expression,maintain |
R6451 |
T10194 |
T10193 |
prep |
of,expression |
R6452 |
T10195 |
T10196 |
compound |
ECM,components |
R6453 |
T10196 |
T10194 |
pobj |
components,of |
R6454 |
T10197 |
T10149 |
punct |
.,suggest |
R6455 |
T10199 |
T10200 |
det |
These,models |
R6456 |
T10200 |
T10201 |
nsubj |
models,are |
R6457 |
T10202 |
T10201 |
acomp |
consistent,are |
R6458 |
T10203 |
T10202 |
prep |
with,consistent |
R6459 |
T10204 |
T10205 |
det |
the,ability |
R6460 |
T10205 |
T10203 |
pobj |
ability,with |
R6461 |
T10206 |
T10205 |
prep |
of,ability |
R6462 |
T10207 |
T10206 |
pobj |
BMP2,of |
R6463 |
T10208 |
T10209 |
aux |
to,increase |
R6464 |
T10209 |
T10205 |
acl |
increase,ability |
R6465 |
T10210 |
T10209 |
preconj |
both,increase |
R6466 |
T10211 |
T10212 |
compound |
PKA,activity |
R6467 |
T10212 |
T10209 |
dobj |
activity,increase |
R6468 |
T10213 |
T10209 |
cc |
and,increase |
R6469 |
T10214 |
T10209 |
conj |
induce,increase |
R6470 |
T10215 |
T10214 |
dobj |
expression,induce |
R6471 |
T10216 |
T10215 |
prep |
of,expression |
R6472 |
T10217 |
T10216 |
pobj |
Sox6,of |
R6473 |
T10218 |
T10214 |
prep |
in,induce |
R6474 |
T10219 |
T10220 |
compound |
tissue,cells |
R6475 |
T10220 |
T10218 |
pobj |
cells,in |
R6476 |
T10221 |
T10220 |
compound |
culture,cells |
R6477 |
T10222 |
T10223 |
punct |
(,Lee |
R6478 |
T10223 |
T10201 |
meta |
Lee,are |
R6479 |
T10224 |
T10223 |
cc |
and,Lee |
R6480 |
T10225 |
T10223 |
conj |
Chuong,Lee |
R6481 |
T10226 |
T10225 |
nummod |
1997,Chuong |
R6482 |
T10227 |
T10225 |
punct |
;,Chuong |
R6483 |
T10228 |
T10225 |
conj |
Fernandez,Chuong |
R6484 |
T10229 |
T10228 |
punct |
-,Fernandez |
R6485 |
T10230 |
T10228 |
nmod |
Lloris,Fernandez |
R6486 |
T10231 |
T10228 |
nmod |
et,Fernandez |
R6487 |
T10232 |
T10228 |
nmod |
al.,Fernandez |
R6488 |
T10233 |
T10228 |
nummod |
2003,Fernandez |
R6489 |
T10234 |
T10228 |
punct |
),Fernandez |
R6490 |
T10235 |
T10201 |
punct |
.,are |
R6491 |
T10237 |
T10238 |
mark |
Although,tried |
R6492 |
T10238 |
T10241 |
advcl |
tried,been |
R6493 |
T10239 |
T10238 |
nsubj |
we,tried |
R6494 |
T10240 |
T10238 |
aux |
have,tried |
R6495 |
T10242 |
T10243 |
aux |
to,monitor |
R6496 |
T10243 |
T10238 |
xcomp |
monitor,tried |
R6497 |
T10244 |
T10245 |
det |
the,expression |
R6498 |
T10245 |
T10243 |
dobj |
expression,monitor |
R6499 |
T10246 |
T10245 |
prep |
of,expression |
R6500 |
T10247 |
T10248 |
compound |
L,Sox5 |
R6501 |
T10248 |
T10246 |
pobj |
Sox5,of |
R6502 |
T10249 |
T10248 |
punct |
-,Sox5 |
R6503 |
T10250 |
T10248 |
cc |
or,Sox5 |
R6504 |
T10251 |
T10248 |
conj |
Sox6,Sox5 |
R6505 |
T10252 |
T10243 |
prep |
in,monitor |
R6506 |
T10253 |
T10254 |
amod |
postnatal,cartilage |
R6507 |
T10254 |
T10252 |
pobj |
cartilage,in |
R6508 |
T10255 |
T10254 |
amod |
articular,cartilage |
R6509 |
T10256 |
T10243 |
punct |
", ",monitor |
R6510 |
T10257 |
T10243 |
cc |
and,monitor |
R6511 |
T10258 |
T10243 |
conj |
test,monitor |
R6512 |
T10259 |
T10260 |
det |
the,state |
R6513 |
T10260 |
T10258 |
dobj |
state,test |
R6514 |
T10261 |
T10260 |
compound |
phosphorylation,state |
R6515 |
T10262 |
T10260 |
prep |
of,state |
R6516 |
T10263 |
T10262 |
pobj |
SOX9,of |
R6517 |
T10264 |
T10258 |
advcl |
using,test |
R6518 |
T10265 |
T10266 |
advmod |
previously,described |
R6519 |
T10266 |
T10267 |
amod |
described,reagents |
R6520 |
T10267 |
T10264 |
dobj |
reagents,using |
R6521 |
T10268 |
T10269 |
punct |
(,Lefebvre |
R6522 |
T10269 |
T10258 |
meta |
Lefebvre,test |
R6523 |
T10270 |
T10269 |
nmod |
et,Lefebvre |
R6524 |
T10271 |
T10269 |
nmod |
al.,Lefebvre |
R6525 |
T10272 |
T10269 |
nummod |
1998,Lefebvre |
R6526 |
T10273 |
T10269 |
punct |
;,Lefebvre |
R6527 |
T10274 |
T10269 |
nmod |
Huang,Lefebvre |
R6528 |
T10275 |
T10269 |
nmod |
et,Lefebvre |
R6529 |
T10276 |
T10269 |
nmod |
al.,Lefebvre |
R6530 |
T10277 |
T10269 |
nummod |
2000,Lefebvre |
R6531 |
T10278 |
T10269 |
punct |
),Lefebvre |
R6532 |
T10279 |
T10241 |
punct |
", ",been |
R6533 |
T10280 |
T10241 |
nsubj |
we,been |
R6534 |
T10281 |
T10241 |
aux |
have,been |
R6535 |
T10282 |
T10241 |
acomp |
unable,been |
R6536 |
T10283 |
T10284 |
aux |
to,obtain |
R6537 |
T10284 |
T10282 |
xcomp |
obtain,unable |
R6538 |
T10285 |
T10286 |
amod |
specific,signal |
R6539 |
T10286 |
T10284 |
dobj |
signal,obtain |
R6540 |
T10287 |
T10284 |
prep |
at,obtain |
R6541 |
T10288 |
T10289 |
det |
the,stages |
R6542 |
T10289 |
T10287 |
pobj |
stages,at |
R6543 |
T10290 |
T10289 |
amod |
late,stages |
R6544 |
T10291 |
T10289 |
amod |
postnatal,stages |
R6545 |
T10292 |
T10289 |
acl |
required,stages |
R6546 |
T10293 |
T10294 |
punct |
(,data |
R6547 |
T10294 |
T10241 |
meta |
data,been |
R6548 |
T10295 |
T10294 |
amod |
unpublished,data |
R6549 |
T10296 |
T10294 |
punct |
),data |
R6550 |
T10297 |
T10241 |
punct |
.,been |
R6551 |
T10299 |
T10300 |
advmod |
Furthermore,cause |
R6552 |
T10301 |
T10300 |
punct |
", ",cause |
R6553 |
T10302 |
T10303 |
amod |
null,mutations |
R6554 |
T10303 |
T10300 |
nsubj |
mutations,cause |
R6555 |
T10304 |
T10303 |
prep |
in,mutations |
R6556 |
T10305 |
T10306 |
compound |
L,Sox5 |
R6557 |
T10306 |
T10304 |
pobj |
Sox5,in |
R6558 |
T10307 |
T10306 |
punct |
-,Sox5 |
R6559 |
T10308 |
T10306 |
cc |
or,Sox5 |
R6560 |
T10309 |
T10306 |
conj |
Sox,Sox5 |
R6561 |
T10310 |
T10309 |
punct |
-,Sox |
R6562 |
T10311 |
T10309 |
nummod |
6,Sox |
R6563 |
T10312 |
T10300 |
dobj |
lethality,cause |
R6564 |
T10313 |
T10312 |
prep |
at,lethality |
R6565 |
T10314 |
T10313 |
cc |
or,at |
R6566 |
T10315 |
T10316 |
advmod |
soon,after |
R6567 |
T10316 |
T10313 |
conj |
after,at |
R6568 |
T10317 |
T10316 |
pobj |
birth,after |
R6569 |
T10318 |
T10300 |
punct |
", ",cause |
R6570 |
T10319 |
T10300 |
cc |
and,cause |
R6571 |
T10320 |
T10321 |
det |
no,effect |
R6572 |
T10321 |
T10322 |
nsubjpass |
effect,reported |
R6573 |
T10322 |
T10300 |
conj |
reported,cause |
R6574 |
T10323 |
T10321 |
prep |
on,effect |
R6575 |
T10324 |
T10325 |
compound |
cartilage,maintenance |
R6576 |
T10325 |
T10323 |
pobj |
maintenance,on |
R6577 |
T10326 |
T10322 |
aux |
has,reported |
R6578 |
T10327 |
T10322 |
auxpass |
been,reported |
R6579 |
T10328 |
T10329 |
punct |
(,Smits |
R6580 |
T10329 |
T10322 |
meta |
Smits,reported |
R6581 |
T10330 |
T10329 |
nmod |
et,Smits |
R6582 |
T10331 |
T10329 |
nmod |
al.,Smits |
R6583 |
T10332 |
T10329 |
nummod |
2001,Smits |
R6584 |
T10333 |
T10329 |
punct |
),Smits |
R6585 |
T10334 |
T10322 |
punct |
.,reported |
R6586 |
T10336 |
T10337 |
advmod |
However,seems |
R6587 |
T10338 |
T10337 |
punct |
", ",seems |
R6588 |
T10339 |
T10337 |
nsubj |
it,seems |
R6589 |
T10340 |
T10337 |
oprd |
likely,seems |
R6590 |
T10341 |
T10342 |
mark |
that,cooperate |
R6591 |
T10342 |
T10337 |
ccomp |
cooperate,seems |
R6592 |
T10343 |
T10342 |
nsubj |
these,cooperate |
R6593 |
T10344 |
T10343 |
cc |
or,these |
R6594 |
T10345 |
T10346 |
amod |
other,processes |
R6595 |
T10346 |
T10343 |
conj |
processes,these |
R6596 |
T10347 |
T10346 |
acl |
regulated,processes |
R6597 |
T10348 |
T10347 |
agent |
by,regulated |
R6598 |
T10349 |
T10350 |
compound |
BMP,signaling |
R6599 |
T10350 |
T10348 |
pobj |
signaling,by |
R6600 |
T10351 |
T10342 |
prep |
with,cooperate |
R6601 |
T10352 |
T10351 |
pobj |
SOX9,with |
R6602 |
T10353 |
T10354 |
aux |
to,induce |
R6603 |
T10354 |
T10342 |
advcl |
induce,cooperate |
R6604 |
T10355 |
T10356 |
amod |
target,genes |
R6605 |
T10356 |
T10354 |
dobj |
genes,induce |
R6606 |
T10357 |
T10354 |
prep |
in,induce |
R6607 |
T10358 |
T10359 |
amod |
articular,cartilage |
R6608 |
T10359 |
T10357 |
pobj |
cartilage,in |
R6609 |
T10360 |
T10337 |
punct |
.,seems |