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PMC:523229 / 34445-40392 JSONTXT

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Id Subject Object Predicate Lexical cue
T7528 0-15 JJ denotes Noninflammatory
T7529 16-28 NN denotes Degeneration
T7530 29-31 IN denotes of
T7531 32-41 JJ denotes Articular
T7532 42-51 NN denotes Cartilage
T7533 52-54 IN denotes in
T7534 55-60 NN denotes Digit
T7535 70-76 NN denotes Joints
T7536 61-64 CC denotes and
T7537 65-69 NN denotes Knee
T7538 76-176 sentence denotes Outside of the ankle region, little or no evidence was seen for expansion of the synovial membrane.
T7539 77-84 IN denotes Outside
T7540 132-136 VBN denotes seen
T7541 85-87 IN denotes of
T7542 88-91 DT denotes the
T7543 98-104 NN denotes region
T7544 92-97 NN denotes ankle
T7545 104-106 , denotes ,
T7546 106-112 JJ denotes little
T7547 113-115 CC denotes or
T7548 116-118 DT denotes no
T7549 119-127 NN denotes evidence
T7550 128-131 VBD denotes was
T7551 137-140 IN denotes for
T7552 141-150 NN denotes expansion
T7553 151-153 IN denotes of
T7554 154-157 DT denotes the
T7555 167-175 NN denotes membrane
T7556 158-166 JJ denotes synovial
T7557 175-176 . denotes .
T7558 176-300 sentence denotes Instead, mutant mice showed histological signs of osteoarthritis, such as fibrillation of the articular surface (Figure 7).
T7559 177-184 RB denotes Instead
T7560 198-204 VBD denotes showed
T7561 184-186 , denotes ,
T7562 186-192 NN denotes mutant
T7563 193-197 NNS denotes mice
T7564 205-217 JJ denotes histological
T7565 218-223 NNS denotes signs
T7566 224-226 IN denotes of
T7567 227-241 NN denotes osteoarthritis
T7568 241-243 , denotes ,
T7569 243-247 JJ denotes such
T7570 248-250 IN denotes as
T7571 251-263 NN denotes fibrillation
T7572 264-266 IN denotes of
T7573 267-270 DT denotes the
T7574 281-288 NN denotes surface
T7575 271-280 JJ denotes articular
T7576 289-290 -LRB- denotes (
T7577 290-296 NN denotes Figure
T7578 297-298 CD denotes 7
T7579 298-299 -RRB- denotes )
T7580 299-300 . denotes .
T7581 300-562 sentence denotes As previously seen in 1- and 2-wk-old animals, Safranin O staining and Agg and Col10 expression were all reduced in mutant articular regions of the forefeet and hindfeet by 7 wk of age, and the beginning signs of cartilage loss were observed (unpublished data).
T7582 301-303 IN denotes As
T7583 315-319 VBN denotes seen
T7584 304-314 RB denotes previously
T7585 406-413 VBN denotes reduced
T7586 320-322 IN denotes in
T7587 323-324 CD denotes 1
T7588 332-334 NN denotes wk
T7589 324-325 HYPH denotes -
T7590 326-329 CC denotes and
T7591 330-331 CD denotes 2
T7592 331-332 HYPH denotes -
T7593 335-338 JJ denotes old
T7594 334-335 HYPH denotes -
T7595 339-346 NNS denotes animals
T7596 346-348 , denotes ,
T7597 348-356 NN denotes Safranin
T7598 357-358 NN denotes O
T7599 359-367 NN denotes staining
T7600 368-371 CC denotes and
T7601 372-375 NN denotes Agg
T7602 386-396 NN denotes expression
T7603 376-379 CC denotes and
T7604 380-385 NN denotes Col10
T7605 397-401 VBD denotes were
T7606 402-405 RB denotes all
T7607 414-416 IN denotes in
T7608 417-423 NN denotes mutant
T7609 434-441 NNS denotes regions
T7610 424-433 JJ denotes articular
T7611 442-444 IN denotes of
T7612 445-448 DT denotes the
T7613 449-457 NNS denotes forefeet
T7614 458-461 CC denotes and
T7615 462-470 NN denotes hindfeet
T7616 471-473 IN denotes by
T7617 474-475 CD denotes 7
T7618 476-478 NN denotes wk
T7619 479-481 IN denotes of
T7620 482-485 NN denotes age
T7621 485-487 , denotes ,
T7622 487-490 CC denotes and
T7623 491-494 DT denotes the
T7624 505-510 NNS denotes signs
T7625 495-504 NN denotes beginning
T7626 534-542 VBN denotes observed
T7627 511-513 IN denotes of
T7628 514-523 NN denotes cartilage
T7629 524-528 NN denotes loss
T7630 529-533 VBD denotes were
T7631 543-544 -LRB- denotes (
T7632 556-560 NNS denotes data
T7633 544-555 JJ denotes unpublished
T7634 560-561 -RRB- denotes )
T7635 561-562 . denotes .
T7636 562-727 sentence denotes By 9 mo of age, many regions of articular cartilage were completely missing or extremely fibrillated, leaving regions of exposed bone on the surface (Figure 7A–7D).
T7637 563-565 IN denotes By
T7638 615-619 VBD denotes were
T7639 566-567 CD denotes 9
T7640 568-570 NN denotes mo
T7641 571-573 IN denotes of
T7642 574-577 NN denotes age
T7643 577-579 , denotes ,
T7644 579-583 JJ denotes many
T7645 584-591 NNS denotes regions
T7646 592-594 IN denotes of
T7647 595-604 JJ denotes articular
T7648 605-614 NN denotes cartilage
T7649 620-630 RB denotes completely
T7650 631-638 VBG denotes missing
T7651 639-641 CC denotes or
T7652 642-651 RB denotes extremely
T7653 652-663 VBN denotes fibrillated
T7654 663-665 , denotes ,
T7655 665-672 VBG denotes leaving
T7656 673-680 NNS denotes regions
T7657 681-683 IN denotes of
T7658 684-691 VBN denotes exposed
T7659 692-696 NN denotes bone
T7660 697-699 IN denotes on
T7661 700-703 DT denotes the
T7662 704-711 NN denotes surface
T7663 712-713 -LRB- denotes (
T7664 720-722 CD denotes 7A
T7665 713-719 NN denotes Figure
T7666 722-723 SYM denotes –
T7667 723-725 CD denotes 7D
T7668 725-726 -RRB- denotes )
T7669 726-727 . denotes .
T7670 727-847 sentence denotes No alterations were seen in the expression of Osteocalcin, Col1a1, or matrix metalloprotease-13 at either 7 wk or 9 mo.
T7671 728-730 DT denotes No
T7672 731-742 NNS denotes alterations
T7673 748-752 VBN denotes seen
T7674 743-747 VBD denotes were
T7675 753-755 IN denotes in
T7676 756-759 DT denotes the
T7677 760-770 NN denotes expression
T7678 771-773 IN denotes of
T7679 774-785 NN denotes Osteocalcin
T7680 785-787 , denotes ,
T7681 787-793 NN denotes Col1a1
T7682 793-795 , denotes ,
T7683 795-797 CC denotes or
T7684 798-804 NN denotes matrix
T7685 805-820 NN denotes metalloprotease
T7686 820-821 HYPH denotes -
T7687 821-823 CD denotes 13
T7688 824-826 IN denotes at
T7689 827-833 CC denotes either
T7690 836-838 NNS denotes wk
T7691 834-835 CD denotes 7
T7692 839-841 CC denotes or
T7693 842-843 CD denotes 9
T7694 844-846 NNS denotes mo
T7695 846-847 . denotes .
T7696 847-2701 sentence denotes Figure 7 Loss of Bmpr1a Signaling Leads to Articular Cartilage Fibrillation and Degeneration in Digits and Knees of Aging Mice (A–D) Near adjacent sections of metatarsal-phalangeal joints from 9 month old mice. Articular cartilage of controls is complete and stains strongly with Safranin O (A, orange stain). In contrast, articular cells of mutants are severely fibrillated or absent with much reduced staining of Safranin O (C, arrowheads). LACZ expression confirms Cre-mediated recombination has occurred in articular cells (B and D). (E–P) Sagittal sections through knee joints of 7-wk- (E–J) or 9-mo-old animals (K–P); fe, femur; ti, tibia; gp, growth plate. Seven weeks after birth, the height of the tibial epiphysis is reduced in mutants (E and H, bars), and their articular layer stains poorly with Safranin O, is fibrillated, and is strikingly thinner (F and I, black arrowhead, and brackets). Near adjacent sections with LACZ staining confirm Cre-mediated recombination has occurred in articular cells (G and J). Note that in mutants, LACZ is absent in cells adjacent to those that do stain with Safranin O, suggesting Bmpr1a may act cell autonomously (I and J, white arrowheads). At 9 mo old, the mutant tibial epiphysis is extremely thin (K and N, bars), and the articular layer is completely absent, leaving bone to rub directly on bone (L and O, bracket). LACZ staining shows Cre-mediated recombination occurred in articular cells of controls (M) and in some remaining skeletal tissue of mutants (P). Also note aberrantly formed meniscal cartilage in mutants (E, H, K, and N, arrows), and increased sclerosis in mutant epiphyses (E, H, K, and N, asterisks). (A and K) Scale bar = 50 μm; (I) scale bar = 300 μm. The major weight-bearing joint of the hindlimb, the knee, showed changes that closely paralleled that seen in the foot joints.
T7697 2575-2578 DT denotes The
T7698 2600-2605 NN denotes joint
T7699 2579-2584 JJ denotes major
T7700 2585-2591 NN denotes weight
T7701 2591-2592 HYPH denotes -
T7702 2592-2599 VBG denotes bearing
T7703 2633-2639 VBD denotes showed
T7704 2606-2608 IN denotes of
T7705 2609-2612 DT denotes the
T7706 2613-2621 NN denotes hindlimb
T7707 2621-2623 , denotes ,
T7708 2623-2626 DT denotes the
T7709 2627-2631 NN denotes knee
T7710 2631-2633 , denotes ,
T7711 2640-2647 NNS denotes changes
T7712 2648-2652 WDT denotes that
T7713 2661-2671 VBD denotes paralleled
T7714 2653-2660 RB denotes closely
T7715 2672-2676 DT denotes that
T7716 2677-2681 VBN denotes seen
T7717 2682-2684 IN denotes in
T7718 2685-2688 DT denotes the
T7719 2694-2700 NNS denotes joints
T7720 2689-2693 NN denotes foot
T7721 2700-2701 . denotes .
T7722 2701-2857 sentence denotes All markers of cartilage matrix looked similar to controls at E16.5, suggesting that early stages of joint formation were not disrupted (unpublished data).
T7723 2702-2705 DT denotes All
T7724 2706-2713 NNS denotes markers
T7725 2734-2740 VBD denotes looked
T7726 2714-2716 IN denotes of
T7727 2717-2726 NN denotes cartilage
T7728 2727-2733 NN denotes matrix
T7729 2741-2748 JJ denotes similar
T7730 2749-2751 IN denotes to
T7731 2752-2760 NNS denotes controls
T7732 2761-2763 IN denotes at
T7733 2764-2769 NN denotes E16.5
T7734 2769-2771 , denotes ,
T7735 2771-2781 VBG denotes suggesting
T7736 2782-2786 IN denotes that
T7737 2828-2837 VBN denotes disrupted
T7738 2787-2792 JJ denotes early
T7739 2793-2799 NNS denotes stages
T7740 2800-2802 IN denotes of
T7741 2803-2808 NN denotes joint
T7742 2809-2818 NN denotes formation
T7743 2819-2823 VBD denotes were
T7744 2824-2827 RB denotes not
T7745 2838-2839 -LRB- denotes (
T7746 2851-2855 NNS denotes data
T7747 2839-2850 JJ denotes unpublished
T7748 2855-2856 -RRB- denotes )
T7749 2856-2857 . denotes .
T7750 2857-3020 sentence denotes By postnatal day 7, Safranin O staining and Col2a1 and Agg expression were clearly reduced in the mutant, despite continued expression of Sox9 (unpublished data).
T7751 2858-2860 IN denotes By
T7752 2941-2948 VBN denotes reduced
T7753 2861-2870 JJ denotes postnatal
T7754 2871-2874 NN denotes day
T7755 2875-2876 CD denotes 7
T7756 2876-2878 , denotes ,
T7757 2878-2886 NN denotes Safranin
T7758 2887-2888 NN denotes O
T7759 2889-2897 NN denotes staining
T7760 2898-2901 CC denotes and
T7761 2902-2908 NN denotes Col2a1
T7762 2917-2927 NN denotes expression
T7763 2909-2912 CC denotes and
T7764 2913-2916 NN denotes Agg
T7765 2928-2932 VBD denotes were
T7766 2933-2940 RB denotes clearly
T7767 2949-2951 IN denotes in
T7768 2952-2955 DT denotes the
T7769 2956-2962 NN denotes mutant
T7770 2962-2964 , denotes ,
T7771 2964-2971 IN denotes despite
T7772 2972-2981 VBN denotes continued
T7773 2982-2992 NN denotes expression
T7774 2993-2995 IN denotes of
T7775 2996-3000 NN denotes Sox9
T7776 3001-3002 -LRB- denotes (
T7777 3014-3018 NNS denotes data
T7778 3002-3013 JJ denotes unpublished
T7779 3018-3019 -RRB- denotes )
T7780 3019-3020 . denotes .
T7781 3020-3229 sentence denotes The overall shape of mutant knee skeletal elements appeared similar to controls, although the fibrocartilaginous meniscus that resides between the femur and tibia appeared much less dense in mutants at E16.5.
T7782 3021-3024 DT denotes The
T7783 3033-3038 NN denotes shape
T7784 3025-3032 JJ denotes overall
T7785 3072-3080 VBD denotes appeared
T7786 3039-3041 IN denotes of
T7787 3042-3048 NN denotes mutant
T7788 3049-3053 NN denotes knee
T7789 3063-3071 NNS denotes elements
T7790 3054-3062 JJ denotes skeletal
T7791 3081-3088 JJ denotes similar
T7792 3089-3091 IN denotes to
T7793 3092-3100 NNS denotes controls
T7794 3100-3102 , denotes ,
T7795 3102-3110 IN denotes although
T7796 3184-3192 VBD denotes appeared
T7797 3111-3114 DT denotes the
T7798 3134-3142 NN denotes meniscus
T7799 3115-3133 NN denotes fibrocartilaginous
T7800 3143-3147 WDT denotes that
T7801 3148-3155 VBZ denotes resides
T7802 3156-3163 IN denotes between
T7803 3164-3167 DT denotes the
T7804 3168-3173 NN denotes femur
T7805 3174-3177 CC denotes and
T7806 3178-3183 NN denotes tibia
T7807 3193-3197 RB denotes much
T7808 3198-3202 RBR denotes less
T7809 3203-3208 JJ denotes dense
T7810 3209-3211 IN denotes in
T7811 3212-3219 NNS denotes mutants
T7812 3220-3222 IN denotes at
T7813 3223-3228 NN denotes E16.5
T7814 3228-3229 . denotes .
T7815 3229-3417 sentence denotes Some cartilage formed in the meniscus region, but the size of these elements was greatly reduced and contained abundant cells with fibrous, noncartilaginous appearance (unpublished data).
T7816 3230-3234 DT denotes Some
T7817 3235-3244 NN denotes cartilage
T7818 3245-3251 VBN denotes formed
T7819 3252-3254 IN denotes in
T7820 3255-3258 DT denotes the
T7821 3268-3274 NN denotes region
T7822 3259-3267 NN denotes meniscus
T7823 3274-3276 , denotes ,
T7824 3276-3279 CC denotes but
T7825 3280-3283 DT denotes the
T7826 3284-3288 NN denotes size
T7827 3319-3326 VBN denotes reduced
T7828 3289-3291 IN denotes of
T7829 3292-3297 DT denotes these
T7830 3298-3306 NNS denotes elements
T7831 3307-3310 VBD denotes was
T7832 3311-3318 RB denotes greatly
T7833 3327-3330 CC denotes and
T7834 3331-3340 VBN denotes contained
T7835 3341-3349 JJ denotes abundant
T7836 3350-3355 NNS denotes cells
T7837 3356-3360 IN denotes with
T7838 3361-3368 JJ denotes fibrous
T7839 3387-3397 NN denotes appearance
T7840 3368-3370 , denotes ,
T7841 3370-3386 JJ denotes noncartilaginous
T7842 3398-3399 -LRB- denotes (
T7843 3411-3415 NNS denotes data
T7844 3399-3410 JJ denotes unpublished
T7845 3415-3416 -RRB- denotes )
T7846 3416-3417 . denotes .
T7847 3417-3546 sentence denotes This reduction of the meniscus can also be seen in sections from 7-wk- and 9-mo-old animals (Figure 7E, 7H, 7K, and 7N, arrows).
T7848 3418-3422 DT denotes This
T7849 3423-3432 NN denotes reduction
T7850 3461-3465 VBN denotes seen
T7851 3433-3435 IN denotes of
T7852 3436-3439 DT denotes the
T7853 3440-3448 NN denotes meniscus
T7854 3449-3452 MD denotes can
T7855 3453-3457 RB denotes also
T7856 3458-3460 VB denotes be
T7857 3466-3468 IN denotes in
T7858 3469-3477 NNS denotes sections
T7859 3478-3482 IN denotes from
T7860 3483-3484 CD denotes 7
T7861 3485-3487 NN denotes wk
T7862 3484-3485 HYPH denotes -
T7863 3498-3501 JJ denotes old
T7864 3487-3488 HYPH denotes -
T7865 3489-3492 CC denotes and
T7866 3493-3494 CD denotes 9
T7867 3495-3497 NN denotes mo
T7868 3494-3495 HYPH denotes -
T7869 3497-3498 HYPH denotes -
T7870 3502-3509 NNS denotes animals
T7871 3510-3511 -LRB- denotes (
T7872 3538-3544 NNS denotes arrows
T7873 3511-3517 NN denotes Figure
T7874 3518-3520 CD denotes 7E
T7875 3520-3522 , denotes ,
T7876 3522-3524 CD denotes 7H
T7877 3524-3526 , denotes ,
T7878 3526-3528 CD denotes 7K
T7879 3528-3530 , denotes ,
T7880 3530-3533 CC denotes and
T7881 3534-3536 CD denotes 7N
T7882 3536-3538 , denotes ,
T7883 3544-3545 -RRB- denotes )
T7884 3545-3546 . denotes .
T7885 3546-3769 sentence denotes At 7 wk of age the normally domed tibial epiphysis was flattened and depressed in the knees of mutant animals, markedly reducing the distance between the growth plate and articular surface (Figure 7E and 7H, vertical bar).
T7886 3547-3549 IN denotes At
T7887 3602-3611 VBN denotes flattened
T7888 3550-3551 CD denotes 7
T7889 3552-3554 NNS denotes wk
T7890 3555-3557 IN denotes of
T7891 3558-3561 NN denotes age
T7892 3562-3565 DT denotes the
T7893 3588-3597 NN denotes epiphysis
T7894 3566-3574 RB denotes normally
T7895 3575-3580 VBN denotes domed
T7896 3581-3587 JJ denotes tibial
T7897 3598-3601 VBD denotes was
T7898 3612-3615 CC denotes and
T7899 3616-3625 VBN denotes depressed
T7900 3626-3628 IN denotes in
T7901 3629-3632 DT denotes the
T7902 3633-3638 NNS denotes knees
T7903 3639-3641 IN denotes of
T7904 3642-3648 NN denotes mutant
T7905 3649-3656 NNS denotes animals
T7906 3656-3658 , denotes ,
T7907 3658-3666 RB denotes markedly
T7908 3667-3675 VBG denotes reducing
T7909 3676-3679 DT denotes the
T7910 3680-3688 NN denotes distance
T7911 3689-3696 IN denotes between
T7912 3697-3700 DT denotes the
T7913 3708-3713 NN denotes plate
T7914 3701-3707 NN denotes growth
T7915 3714-3717 CC denotes and
T7916 3718-3727 JJ denotes articular
T7917 3728-3735 NN denotes surface
T7918 3736-3737 -LRB- denotes (
T7919 3764-3767 NN denotes bar
T7920 3737-3743 NN denotes Figure
T7921 3744-3746 CD denotes 7E
T7922 3747-3750 CC denotes and
T7923 3751-3753 CD denotes 7H
T7924 3753-3755 , denotes ,
T7925 3755-3763 JJ denotes vertical
T7926 3767-3768 -RRB- denotes )
T7927 3768-3769 . denotes .
T7928 3769-3974 sentence denotes Articular cartilage was also thinner than in control animals, showed nearly complete absence of Safranin O staining, and was either acellular or beginning to fibrillate in many regions (Figure 7F and 7I).
T7929 3770-3779 JJ denotes Articular
T7930 3780-3789 NN denotes cartilage
T7931 3790-3793 VBD denotes was
T7932 3794-3798 RB denotes also
T7933 3799-3806 JJR denotes thinner
T7934 3807-3811 IN denotes than
T7935 3812-3814 IN denotes in
T7936 3815-3822 NN denotes control
T7937 3823-3830 NNS denotes animals
T7938 3830-3832 , denotes ,
T7939 3832-3838 VBD denotes showed
T7940 3839-3845 RB denotes nearly
T7941 3846-3854 JJ denotes complete
T7942 3855-3862 NN denotes absence
T7943 3863-3865 IN denotes of
T7944 3866-3874 NN denotes Safranin
T7945 3875-3876 NN denotes O
T7946 3877-3885 NN denotes staining
T7947 3885-3887 , denotes ,
T7948 3887-3890 CC denotes and
T7949 3891-3894 VBD denotes was
T7950 3895-3901 CC denotes either
T7951 3902-3911 JJ denotes acellular
T7952 3912-3914 CC denotes or
T7953 3915-3924 VBG denotes beginning
T7954 3925-3927 TO denotes to
T7955 3928-3938 VB denotes fibrillate
T7956 3939-3941 IN denotes in
T7957 3942-3946 JJ denotes many
T7958 3947-3954 NNS denotes regions
T7959 3955-3956 -LRB- denotes (
T7960 3956-3962 NN denotes Figure
T7961 3963-3965 CD denotes 7F
T7962 3966-3969 CC denotes and
T7963 3970-3972 CD denotes 7I
T7964 3972-3973 -RRB- denotes )
T7965 3973-3974 . denotes .
T7966 3974-4255 sentence denotes The few large Safranin O-stained cells still apparent in mutant articular regions appeared to correspond in position to rare LACZ-negative cells in adjacent sections, suggesting that Bmpr1a is required cell-autonomously in articular cartilage (Figure 7I and 7J, white arrowheads).
T7967 3975-3978 DT denotes The
T7968 4008-4013 NNS denotes cells
T7969 3979-3982 JJ denotes few
T7970 3983-3988 JJ denotes large
T7971 3989-3997 NN denotes Safranin
T7972 3998-3999 NN denotes O
T7973 4000-4007 VBN denotes stained
T7974 3999-4000 HYPH denotes -
T7975 4057-4065 VBD denotes appeared
T7976 4014-4019 RB denotes still
T7977 4020-4028 JJ denotes apparent
T7978 4029-4031 IN denotes in
T7979 4032-4038 NN denotes mutant
T7980 4049-4056 NNS denotes regions
T7981 4039-4048 JJ denotes articular
T7982 4066-4068 TO denotes to
T7983 4069-4079 VB denotes correspond
T7984 4080-4082 IN denotes in
T7985 4083-4091 NN denotes position
T7986 4092-4094 IN denotes to
T7987 4095-4099 JJ denotes rare
T7988 4114-4119 NNS denotes cells
T7989 4100-4104 NN denotes LACZ
T7990 4105-4113 JJ denotes negative
T7991 4104-4105 HYPH denotes -
T7992 4120-4122 IN denotes in
T7993 4123-4131 JJ denotes adjacent
T7994 4132-4140 NNS denotes sections
T7995 4140-4142 , denotes ,
T7996 4142-4152 VBG denotes suggesting
T7997 4153-4157 IN denotes that
T7998 4168-4176 VBN denotes required
T7999 4158-4164 NN denotes Bmpr1a
T8000 4165-4167 VBZ denotes is
T8001 4177-4181 NN denotes cell
T8002 4182-4194 RB denotes autonomously
T8003 4181-4182 HYPH denotes -
T8004 4195-4197 IN denotes in
T8005 4198-4207 JJ denotes articular
T8006 4208-4217 NN denotes cartilage
T8007 4218-4219 -LRB- denotes (
T8008 4243-4253 NNS denotes arrowheads
T8009 4219-4225 NN denotes Figure
T8010 4226-4228 CD denotes 7I
T8011 4229-4232 CC denotes and
T8012 4233-4235 CD denotes 7J
T8013 4235-4237 , denotes ,
T8014 4237-4242 JJ denotes white
T8015 4253-4254 -RRB- denotes )
T8016 4254-4255 . denotes .
T8017 4255-4406 sentence denotes By 9 mo, large areas of mutant knees were devoid of articular cells, and the bones of the femur and tibia appeared to rub directly against each other.
T8018 4256-4258 IN denotes By
T8019 4293-4297 VBD denotes were
T8020 4259-4260 CD denotes 9
T8021 4261-4263 NN denotes mo
T8022 4263-4265 , denotes ,
T8023 4265-4270 JJ denotes large
T8024 4271-4276 NNS denotes areas
T8025 4277-4279 IN denotes of
T8026 4280-4286 NN denotes mutant
T8027 4287-4292 NNS denotes knees
T8028 4298-4304 JJ denotes devoid
T8029 4305-4307 IN denotes of
T8030 4308-4317 JJ denotes articular
T8031 4318-4323 NNS denotes cells
T8032 4323-4325 , denotes ,
T8033 4325-4328 CC denotes and
T8034 4329-4332 DT denotes the
T8035 4333-4338 NNS denotes bones
T8036 4362-4370 VBD denotes appeared
T8037 4339-4341 IN denotes of
T8038 4342-4345 DT denotes the
T8039 4346-4351 NN denotes femur
T8040 4352-4355 CC denotes and
T8041 4356-4361 NN denotes tibia
T8042 4371-4373 TO denotes to
T8043 4374-4377 VB denotes rub
T8044 4378-4386 RB denotes directly
T8045 4387-4394 IN denotes against
T8046 4395-4399 DT denotes each
T8047 4400-4405 JJ denotes other
T8048 4405-4406 . denotes .
T8049 4406-4592 sentence denotes Furthermore, the epiphysis of the tibia was extremely depressed, to the point that growth plate cartilage was almost exposed through the surface of the bone (Figure 7K, 7L, 7N, and 7O).
T8050 4407-4418 RB denotes Furthermore
T8051 4447-4450 VBD denotes was
T8052 4418-4420 , denotes ,
T8053 4420-4423 DT denotes the
T8054 4424-4433 NN denotes epiphysis
T8055 4434-4436 IN denotes of
T8056 4437-4440 DT denotes the
T8057 4441-4446 NN denotes tibia
T8058 4451-4460 RB denotes extremely
T8059 4461-4470 JJ denotes depressed
T8060 4470-4472 , denotes ,
T8061 4472-4474 IN denotes to
T8062 4475-4478 DT denotes the
T8063 4479-4484 NN denotes point
T8064 4485-4489 IN denotes that
T8065 4524-4531 VBN denotes exposed
T8066 4490-4496 NN denotes growth
T8067 4503-4512 NN denotes cartilage
T8068 4497-4502 NN denotes plate
T8069 4513-4516 VBD denotes was
T8070 4517-4523 RB denotes almost
T8071 4532-4539 IN denotes through
T8072 4540-4543 DT denotes the
T8073 4544-4551 NN denotes surface
T8074 4552-4554 IN denotes of
T8075 4555-4558 DT denotes the
T8076 4559-4563 NN denotes bone
T8077 4564-4565 -LRB- denotes (
T8078 4572-4574 CD denotes 7K
T8079 4565-4571 NN denotes Figure
T8080 4574-4576 , denotes ,
T8081 4576-4578 CD denotes 7L
T8082 4578-4580 , denotes ,
T8083 4580-4582 CD denotes 7N
T8084 4582-4584 , denotes ,
T8085 4584-4587 CC denotes and
T8086 4588-4590 CD denotes 7O
T8087 4590-4591 -RRB- denotes )
T8088 4591-4592 . denotes .
T8089 4592-4741 sentence denotes In addition, mutants at 7 wk and 9 mo showed subchondral sclerosis, especially in the epiphysis of the femur (Figure 7E, 7H, 7K, and 7N, asterisks).
T8090 4593-4595 IN denotes In
T8091 4631-4637 VBD denotes showed
T8092 4596-4604 NN denotes addition
T8093 4604-4606 , denotes ,
T8094 4606-4613 NNS denotes mutants
T8095 4614-4616 IN denotes at
T8096 4617-4618 CD denotes 7
T8097 4619-4621 NNS denotes wk
T8098 4622-4625 CC denotes and
T8099 4626-4627 CD denotes 9
T8100 4628-4630 NNS denotes mo
T8101 4638-4649 JJ denotes subchondral
T8102 4650-4659 NN denotes sclerosis
T8103 4659-4661 , denotes ,
T8104 4661-4671 RB denotes especially
T8105 4672-4674 IN denotes in
T8106 4675-4678 DT denotes the
T8107 4679-4688 NN denotes epiphysis
T8108 4689-4691 IN denotes of
T8109 4692-4695 DT denotes the
T8110 4696-4701 NN denotes femur
T8111 4702-4703 -LRB- denotes (
T8112 4730-4739 NNS denotes asterisks
T8113 4703-4709 NN denotes Figure
T8114 4710-4712 CD denotes 7E
T8115 4712-4714 , denotes ,
T8116 4714-4716 CD denotes 7H
T8117 4716-4718 , denotes ,
T8118 4718-4720 CD denotes 7K
T8119 4720-4722 , denotes ,
T8120 4722-4725 CC denotes and
T8121 4726-4728 CD denotes 7N
T8122 4728-4730 , denotes ,
T8123 4739-4740 -RRB- denotes )
T8124 4740-4741 . denotes .
T8125 4741-5095 sentence denotes While subchondral sclerosis is commonly seen in cases of osteoarthritis, it is unclear in this case whether the sclerosis is mainly a response of bone formation to compensate for decreased articular cartilage, or whether it is the effect of loss of Bmpr1a signaling in some LACZ-positive cells that are also observed in these regions (unpublished data).
T8126 4742-4747 IN denotes While
T8127 4782-4786 VBN denotes seen
T8128 4748-4759 JJ denotes subchondral
T8129 4760-4769 NN denotes sclerosis
T8130 4770-4772 VBZ denotes is
T8131 4773-4781 RB denotes commonly
T8132 4818-4820 VBZ denotes is
T8133 4787-4789 IN denotes in
T8134 4790-4795 NNS denotes cases
T8135 4796-4798 IN denotes of
T8136 4799-4813 NN denotes osteoarthritis
T8137 4813-4815 , denotes ,
T8138 4815-4817 PRP denotes it
T8139 4821-4828 JJ denotes unclear
T8140 4829-4831 IN denotes in
T8141 4832-4836 DT denotes this
T8142 4837-4841 NN denotes case
T8143 4842-4849 IN denotes whether
T8144 4864-4866 VBZ denotes is
T8145 4850-4853 DT denotes the
T8146 4854-4863 NN denotes sclerosis
T8147 4867-4873 RB denotes mainly
T8148 4874-4875 DT denotes a
T8149 4876-4884 NN denotes response
T8150 4885-4887 IN denotes of
T8151 4888-4892 NN denotes bone
T8152 4893-4902 NN denotes formation
T8153 4903-4905 TO denotes to
T8154 4906-4916 VB denotes compensate
T8155 4917-4920 IN denotes for
T8156 4921-4930 VBN denotes decreased
T8157 4941-4950 NN denotes cartilage
T8158 4931-4940 JJ denotes articular
T8159 4950-4952 , denotes ,
T8160 4952-4954 CC denotes or
T8161 4955-4962 IN denotes whether
T8162 4966-4968 VBZ denotes is
T8163 4963-4965 PRP denotes it
T8164 4969-4972 DT denotes the
T8165 4973-4979 NN denotes effect
T8166 4980-4982 IN denotes of
T8167 4983-4987 NN denotes loss
T8168 4988-4990 IN denotes of
T8169 4991-4997 NN denotes Bmpr1a
T8170 4998-5007 NN denotes signaling
T8171 5008-5010 IN denotes in
T8172 5011-5015 DT denotes some
T8173 5030-5035 NNS denotes cells
T8174 5016-5020 NN denotes LACZ
T8175 5021-5029 JJ denotes positive
T8176 5020-5021 HYPH denotes -
T8177 5036-5040 WDT denotes that
T8178 5050-5058 VBN denotes observed
T8179 5041-5044 VBP denotes are
T8180 5045-5049 RB denotes also
T8181 5059-5061 IN denotes in
T8182 5062-5067 DT denotes these
T8183 5068-5075 NNS denotes regions
T8184 5076-5077 -LRB- denotes (
T8185 5089-5093 NNS denotes data
T8186 5077-5088 JJ denotes unpublished
T8187 5093-5094 -RRB- denotes )
T8188 5094-5095 . denotes .
T8189 5095-5244 sentence denotes The histological signs of joint arthritis were accompanied by functional impairments in both grasping ability and range of motion in mutant animals.
T8190 5096-5099 DT denotes The
T8191 5113-5118 NNS denotes signs
T8192 5100-5112 JJ denotes histological
T8193 5143-5154 VBN denotes accompanied
T8194 5119-5121 IN denotes of
T8195 5122-5127 NN denotes joint
T8196 5128-5137 NN denotes arthritis
T8197 5138-5142 VBD denotes were
T8198 5155-5157 IN denotes by
T8199 5158-5168 JJ denotes functional
T8200 5169-5180 NNS denotes impairments
T8201 5181-5183 IN denotes in
T8202 5184-5188 CC denotes both
T8203 5198-5205 NN denotes ability
T8204 5189-5197 VBG denotes grasping
T8205 5206-5209 CC denotes and
T8206 5210-5215 NN denotes range
T8207 5216-5218 IN denotes of
T8208 5219-5225 NN denotes motion
T8209 5226-5228 IN denotes in
T8210 5229-5235 NN denotes mutant
T8211 5236-5243 NNS denotes animals
T8212 5243-5244 . denotes .
T8213 5244-5461 sentence denotes Gdf5-Cre/Bmpr1afloxP mutant animals showed a highly significantly reduced ability to grasp and remain suspended on a slender rod (mean suspension time: controls 38 ± 6 s, n = 39; mutants 6 ± 3 s, n = 11; p < 0.0001).
T8214 5245-5249 NN denotes Gdf5
T8215 5250-5253 NN denotes Cre
T8216 5249-5250 HYPH denotes -
T8217 5254-5265 NN denotes Bmpr1afloxP
T8218 5253-5254 HYPH denotes /
T8219 5266-5272 JJ denotes mutant
T8220 5273-5280 NNS denotes animals
T8221 5281-5287 VBD denotes showed
T8222 5288-5289 DT denotes a
T8223 5319-5326 NN denotes ability
T8224 5290-5296 RB denotes highly
T8225 5297-5310 RB denotes significantly
T8226 5311-5318 VBN denotes reduced
T8227 5327-5329 TO denotes to
T8228 5330-5335 VB denotes grasp
T8229 5336-5339 CC denotes and
T8230 5340-5346 VB denotes remain
T8231 5347-5356 VBN denotes suspended
T8232 5357-5359 IN denotes on
T8233 5360-5361 DT denotes a
T8234 5370-5373 NN denotes rod
T8235 5362-5369 JJ denotes slender
T8236 5374-5375 -LRB- denotes (
T8237 5391-5395 NN denotes time
T8238 5375-5379 JJ denotes mean
T8239 5380-5390 NN denotes suspension
T8240 5395-5397 : denotes :
T8241 5397-5405 NNS denotes controls
T8242 5413-5414 NNS denotes s
T8243 5406-5408 CD denotes 38
T8244 5411-5412 CD denotes 6
T8245 5409-5410 SYM denotes ±
T8246 5438-5439 NNS denotes s
T8247 5414-5416 , denotes ,
T8248 5416-5417 NN denotes n
T8249 5420-5422 CD denotes 39
T8250 5418-5419 SYM denotes =
T8251 5422-5423 : denotes ;
T8252 5424-5431 NNS denotes mutants
T8253 5432-5433 CD denotes 6
T8254 5436-5437 CD denotes 3
T8255 5434-5435 SYM denotes ±
T8256 5439-5441 , denotes ,
T8257 5441-5442 NN denotes n
T8258 5445-5447 CD denotes 11
T8259 5443-5444 SYM denotes =
T8260 5447-5448 : denotes ;
T8261 5449-5450 NN denotes p
T8262 5453-5459 CD denotes 0.0001
T8263 5451-5452 SYM denotes <
T8264 5459-5460 -RRB- denotes )
T8265 5460-5461 . denotes .
T8266 5461-5762 sentence denotes Mutant mice also showed a clear decrease in the maximum range of mobility of two different joints in the digits, as assayed by passive manipulation (MT/P1 joint: controls 100 ± 0°, n = 26; mutants 82 ± 3°, n = 8; p < 0.0003; P1/P2 joint: controls 152 ± 1°, n = 23; mutants 140 ± 5°, n = 6; p < 0.05).
T8267 5462-5468 NN denotes Mutant
T8268 5469-5473 NNS denotes mice
T8269 5479-5485 VBD denotes showed
T8270 5474-5478 RB denotes also
T8271 5486-5487 DT denotes a
T8272 5494-5502 NN denotes decrease
T8273 5488-5493 JJ denotes clear
T8274 5503-5505 IN denotes in
T8275 5506-5509 DT denotes the
T8276 5518-5523 NN denotes range
T8277 5510-5517 JJ denotes maximum
T8278 5524-5526 IN denotes of
T8279 5527-5535 NN denotes mobility
T8280 5536-5538 IN denotes of
T8281 5539-5542 CD denotes two
T8282 5553-5559 NNS denotes joints
T8283 5543-5552 JJ denotes different
T8284 5560-5562 IN denotes in
T8285 5563-5566 DT denotes the
T8286 5567-5573 NNS denotes digits
T8287 5573-5575 , denotes ,
T8288 5575-5577 IN denotes as
T8289 5578-5585 VBN denotes assayed
T8290 5586-5588 IN denotes by
T8291 5589-5596 JJ denotes passive
T8292 5597-5609 NN denotes manipulation
T8293 5610-5611 -LRB- denotes (
T8294 5756-5760 CD denotes 0.05
T8295 5611-5613 NN denotes MT
T8296 5614-5616 NN denotes P1
T8297 5613-5614 HYPH denotes /
T8298 5617-5622 NN denotes joint
T8299 5679-5685 CD denotes 0.0003
T8300 5622-5624 : denotes :
T8301 5624-5632 VBZ denotes controls
T8302 5647-5649 CD denotes 26
T8303 5633-5636 CD denotes 100
T8304 5639-5640 CD denotes 0
T8305 5637-5638 SYM denotes ±
T8306 5640-5641 NNS denotes °
T8307 5641-5643 , denotes ,
T8308 5643-5644 NN denotes n
T8309 5645-5646 SYM denotes =
T8310 5649-5650 : denotes ;
T8311 5651-5658 NNS denotes mutants
T8312 5672-5673 CD denotes 8
T8313 5659-5661 CD denotes 82
T8314 5664-5665 CD denotes 3
T8315 5662-5663 SYM denotes ±
T8316 5665-5666 NNS denotes °
T8317 5666-5668 , denotes ,
T8318 5668-5669 NN denotes n
T8319 5670-5671 SYM denotes =
T8320 5673-5674 : denotes ;
T8321 5675-5676 NN denotes p
T8322 5677-5678 SYM denotes <
T8323 5685-5686 : denotes ;
T8324 5687-5689 NN denotes P1
T8325 5690-5692 NN denotes P2
T8326 5689-5690 HYPH denotes /
T8327 5693-5698 NN denotes joint
T8328 5698-5700 : denotes :
T8329 5700-5708 NNS denotes controls
T8330 5723-5725 CD denotes 23
T8331 5709-5712 CD denotes 152
T8332 5715-5716 CD denotes 1
T8333 5713-5714 SYM denotes ±
T8334 5716-5717 NN denotes °
T8335 5717-5719 , denotes ,
T8336 5719-5720 NN denotes n
T8337 5721-5722 SYM denotes =
T8338 5725-5726 : denotes ;
T8339 5727-5734 NNS denotes mutants
T8340 5749-5750 CD denotes 6
T8341 5735-5738 CD denotes 140
T8342 5741-5742 CD denotes 5
T8343 5739-5740 SYM denotes ±
T8344 5742-5743 NNS denotes °
T8345 5743-5745 , denotes ,
T8346 5745-5746 NN denotes n
T8347 5747-5748 SYM denotes =
T8348 5750-5751 : denotes ;
T8349 5752-5753 NN denotes p
T8350 5754-5755 SYM denotes <
T8351 5760-5761 -RRB- denotes )
T8352 5761-5762 . denotes .
T8353 5762-5947 sentence denotes The structural, histological, marker gene expression, and functional changes in mutant mice demonstrate that BMPR1A is required for normal postnatal maintenance of articular cartilage.
T8354 5763-5766 DT denotes The
T8355 5832-5839 NNS denotes changes
T8356 5767-5777 JJ denotes structural
T8357 5777-5779 , denotes ,
T8358 5779-5791 JJ denotes histological
T8359 5791-5793 , denotes ,
T8360 5793-5799 NN denotes marker
T8361 5800-5804 NN denotes gene
T8362 5805-5815 NN denotes expression
T8363 5815-5817 , denotes ,
T8364 5817-5820 CC denotes and
T8365 5821-5831 JJ denotes functional
T8366 5855-5866 VBP denotes demonstrate
T8367 5840-5842 IN denotes in
T8368 5843-5849 NN denotes mutant
T8369 5850-5854 NNS denotes mice
T8370 5867-5871 IN denotes that
T8371 5882-5890 VBN denotes required
T8372 5872-5878 NN denotes BMPR1A
T8373 5879-5881 VBZ denotes is
T8374 5891-5894 IN denotes for
T8375 5895-5901 JJ denotes normal
T8376 5912-5923 NN denotes maintenance
T8377 5902-5911 JJ denotes postnatal
T8378 5924-5926 IN denotes of
T8379 5927-5936 JJ denotes articular
T8380 5937-5946 NN denotes cartilage
T8381 5946-5947 . denotes .
R4702 T7528 T7529 amod Noninflammatory,Degeneration
R4703 T7530 T7529 prep of,Degeneration
R4704 T7531 T7532 amod Articular,Cartilage
R4705 T7532 T7530 pobj Cartilage,of
R4706 T7533 T7529 prep in,Degeneration
R4707 T7534 T7535 nmod Digit,Joints
R4708 T7535 T7533 pobj Joints,in
R4709 T7536 T7534 cc and,Digit
R4710 T7537 T7534 conj Knee,Digit
R4711 T7539 T7540 prep Outside,seen
R4712 T7541 T7539 prep of,Outside
R4713 T7542 T7543 det the,region
R4714 T7543 T7541 pobj region,of
R4715 T7544 T7543 compound ankle,region
R4716 T7545 T7540 punct ", ",seen
R4717 T7546 T7540 nsubjpass little,seen
R4718 T7547 T7546 cc or,little
R4719 T7548 T7549 nmod no,evidence
R4720 T7549 T7546 conj evidence,little
R4721 T7550 T7540 auxpass was,seen
R4722 T7551 T7540 prep for,seen
R4723 T7552 T7551 pobj expansion,for
R4724 T7553 T7552 prep of,expansion
R4725 T7554 T7555 det the,membrane
R4726 T7555 T7553 pobj membrane,of
R4727 T7556 T7555 amod synovial,membrane
R4728 T7557 T7540 punct .,seen
R4729 T7559 T7560 advmod Instead,showed
R4730 T7561 T7560 punct ", ",showed
R4731 T7562 T7563 compound mutant,mice
R4732 T7563 T7560 nsubj mice,showed
R4733 T7564 T7565 amod histological,signs
R4734 T7565 T7560 dobj signs,showed
R4735 T7566 T7565 prep of,signs
R4736 T7567 T7566 pobj osteoarthritis,of
R4737 T7568 T7565 punct ", ",signs
R4738 T7569 T7570 amod such,as
R4739 T7570 T7565 prep as,signs
R4740 T7571 T7570 pobj fibrillation,as
R4741 T7572 T7571 prep of,fibrillation
R4742 T7573 T7574 det the,surface
R4743 T7574 T7572 pobj surface,of
R4744 T7575 T7574 amod articular,surface
R4745 T7576 T7577 punct (,Figure
R4746 T7577 T7560 parataxis Figure,showed
R4747 T7578 T7577 nummod 7,Figure
R4748 T7579 T7577 punct ),Figure
R4749 T7580 T7560 punct .,showed
R4750 T7582 T7583 mark As,seen
R4751 T7583 T7585 advcl seen,reduced
R4752 T7584 T7583 advmod previously,seen
R4753 T7586 T7583 prep in,seen
R4754 T7587 T7588 nummod 1,wk
R4755 T7588 T7593 npadvmod wk,old
R4756 T7589 T7587 punct -,1
R4757 T7590 T7587 cc and,1
R4758 T7591 T7587 conj 2,1
R4759 T7592 T7591 punct -,2
R4760 T7593 T7595 amod old,animals
R4761 T7594 T7593 punct -,old
R4762 T7595 T7586 pobj animals,in
R4763 T7596 T7585 punct ", ",reduced
R4764 T7597 T7598 compound Safranin,O
R4765 T7598 T7599 compound O,staining
R4766 T7599 T7585 nsubjpass staining,reduced
R4767 T7600 T7599 cc and,staining
R4768 T7601 T7602 nmod Agg,expression
R4769 T7602 T7599 conj expression,staining
R4770 T7603 T7601 cc and,Agg
R4771 T7604 T7601 conj Col10,Agg
R4772 T7605 T7585 auxpass were,reduced
R4773 T7606 T7585 advmod all,reduced
R4774 T7607 T7585 prep in,reduced
R4775 T7608 T7609 nmod mutant,regions
R4776 T7609 T7607 pobj regions,in
R4777 T7610 T7609 amod articular,regions
R4778 T7611 T7609 prep of,regions
R4779 T7612 T7613 det the,forefeet
R4780 T7613 T7611 pobj forefeet,of
R4781 T7614 T7613 cc and,forefeet
R4782 T7615 T7613 conj hindfeet,forefeet
R4783 T7616 T7585 prep by,reduced
R4784 T7617 T7618 nummod 7,wk
R4785 T7618 T7616 pobj wk,by
R4786 T7619 T7618 prep of,wk
R4787 T7620 T7619 pobj age,of
R4788 T7621 T7585 punct ", ",reduced
R4789 T7622 T7585 cc and,reduced
R4790 T7623 T7624 det the,signs
R4791 T7624 T7626 nsubjpass signs,observed
R4792 T7625 T7624 compound beginning,signs
R4793 T7626 T7585 conj observed,reduced
R4794 T7627 T7624 prep of,signs
R4795 T7628 T7629 compound cartilage,loss
R4796 T7629 T7627 pobj loss,of
R4797 T7630 T7626 auxpass were,observed
R4798 T7631 T7632 punct (,data
R4799 T7632 T7626 meta data,observed
R4800 T7633 T7632 amod unpublished,data
R4801 T7634 T7632 punct ),data
R4802 T7635 T7626 punct .,observed
R4803 T7637 T7638 prep By,were
R4804 T7639 T7640 nummod 9,mo
R4805 T7640 T7637 pobj mo,By
R4806 T7641 T7640 prep of,mo
R4807 T7642 T7641 pobj age,of
R4808 T7643 T7638 punct ", ",were
R4809 T7644 T7645 amod many,regions
R4810 T7645 T7638 nsubj regions,were
R4811 T7646 T7645 prep of,regions
R4812 T7647 T7648 amod articular,cartilage
R4813 T7648 T7646 pobj cartilage,of
R4814 T7649 T7650 advmod completely,missing
R4815 T7650 T7638 acomp missing,were
R4816 T7651 T7650 cc or,missing
R4817 T7652 T7653 advmod extremely,fibrillated
R4818 T7653 T7650 conj fibrillated,missing
R4819 T7654 T7638 punct ", ",were
R4820 T7655 T7638 advcl leaving,were
R4821 T7656 T7655 dobj regions,leaving
R4822 T7657 T7656 prep of,regions
R4823 T7658 T7659 amod exposed,bone
R4824 T7659 T7657 pobj bone,of
R4825 T7660 T7655 prep on,leaving
R4826 T7661 T7662 det the,surface
R4827 T7662 T7660 pobj surface,on
R4828 T7663 T7664 punct (,7A
R4829 T7664 T7638 parataxis 7A,were
R4830 T7665 T7664 nmod Figure,7A
R4831 T7666 T7667 punct –,7D
R4832 T7667 T7664 prep 7D,7A
R4833 T7668 T7664 punct ),7A
R4834 T7669 T7638 punct .,were
R4835 T7671 T7672 det No,alterations
R4836 T7672 T7673 nsubjpass alterations,seen
R4837 T7674 T7673 auxpass were,seen
R4838 T7675 T7673 prep in,seen
R4839 T7676 T7677 det the,expression
R4840 T7677 T7675 pobj expression,in
R4841 T7678 T7677 prep of,expression
R4842 T7679 T7678 pobj Osteocalcin,of
R4843 T7680 T7679 punct ", ",Osteocalcin
R4844 T7681 T7679 conj Col1a1,Osteocalcin
R4845 T7682 T7681 punct ", ",Col1a1
R4846 T7683 T7681 cc or,Col1a1
R4847 T7684 T7685 compound matrix,metalloprotease
R4848 T7685 T7681 conj metalloprotease,Col1a1
R4849 T7686 T7685 punct -,metalloprotease
R4850 T7687 T7685 nummod 13,metalloprotease
R4851 T7688 T7673 prep at,seen
R4852 T7689 T7690 preconj either,wk
R4853 T7690 T7688 pobj wk,at
R4854 T7691 T7690 nummod 7,wk
R4855 T7692 T7690 cc or,wk
R4856 T7693 T7694 nummod 9,mo
R4857 T7694 T7690 conj mo,wk
R4858 T7695 T7673 punct .,seen
R4859 T7697 T7698 det The,joint
R4860 T7698 T7703 nsubj joint,showed
R4861 T7699 T7698 amod major,joint
R4862 T7700 T7698 nmod weight,joint
R4863 T7701 T7700 punct -,weight
R4864 T7702 T7700 amod bearing,weight
R4865 T7704 T7698 prep of,joint
R4866 T7705 T7706 det the,hindlimb
R4867 T7706 T7704 pobj hindlimb,of
R4868 T7707 T7698 punct ", ",joint
R4869 T7708 T7709 det the,knee
R4870 T7709 T7698 appos knee,joint
R4871 T7710 T7703 punct ", ",showed
R4872 T7711 T7703 dobj changes,showed
R4873 T7712 T7713 dep that,paralleled
R4874 T7713 T7711 relcl paralleled,changes
R4875 T7714 T7713 advmod closely,paralleled
R4876 T7715 T7713 dobj that,paralleled
R4877 T7716 T7715 acl seen,that
R4878 T7717 T7716 prep in,seen
R4879 T7718 T7719 det the,joints
R4880 T7719 T7717 pobj joints,in
R4881 T7720 T7719 compound foot,joints
R4882 T7721 T7703 punct .,showed
R4883 T7723 T7724 det All,markers
R4884 T7724 T7725 nsubj markers,looked
R4885 T7726 T7724 prep of,markers
R4886 T7727 T7728 compound cartilage,matrix
R4887 T7728 T7726 pobj matrix,of
R4888 T7729 T7725 acomp similar,looked
R4889 T7730 T7729 prep to,similar
R4890 T7731 T7730 pobj controls,to
R4891 T7732 T7725 prep at,looked
R4892 T7733 T7732 pobj E16.5,at
R4893 T7734 T7725 punct ", ",looked
R4894 T7735 T7725 advcl suggesting,looked
R4895 T7736 T7737 mark that,disrupted
R4896 T7737 T7735 ccomp disrupted,suggesting
R4897 T7738 T7739 amod early,stages
R4898 T7739 T7737 nsubjpass stages,disrupted
R4899 T7740 T7739 prep of,stages
R4900 T7741 T7742 compound joint,formation
R4901 T7742 T7740 pobj formation,of
R4902 T7743 T7737 auxpass were,disrupted
R4903 T7744 T7737 neg not,disrupted
R4904 T7745 T7746 punct (,data
R4905 T7746 T7725 meta data,looked
R4906 T7747 T7746 amod unpublished,data
R4907 T7748 T7746 punct ),data
R4908 T7749 T7725 punct .,looked
R4909 T7751 T7752 prep By,reduced
R4910 T7753 T7754 amod postnatal,day
R4911 T7754 T7751 pobj day,By
R4912 T7755 T7754 nummod 7,day
R4913 T7756 T7752 punct ", ",reduced
R4914 T7757 T7758 compound Safranin,O
R4915 T7758 T7759 compound O,staining
R4916 T7759 T7752 nsubjpass staining,reduced
R4917 T7760 T7759 cc and,staining
R4918 T7761 T7762 nmod Col2a1,expression
R4919 T7762 T7759 conj expression,staining
R4920 T7763 T7761 cc and,Col2a1
R4921 T7764 T7761 conj Agg,Col2a1
R4922 T7765 T7752 auxpass were,reduced
R4923 T7766 T7752 advmod clearly,reduced
R4924 T7767 T7752 prep in,reduced
R4925 T7768 T7769 det the,mutant
R4926 T7769 T7767 pobj mutant,in
R4927 T7770 T7752 punct ", ",reduced
R4928 T7771 T7752 prep despite,reduced
R4929 T7772 T7773 amod continued,expression
R4930 T7773 T7771 pobj expression,despite
R4931 T7774 T7773 prep of,expression
R4932 T7775 T7774 pobj Sox9,of
R4933 T7776 T7777 punct (,data
R4934 T7777 T7752 meta data,reduced
R4935 T7778 T7777 amod unpublished,data
R4936 T7779 T7777 punct ),data
R4937 T7780 T7752 punct .,reduced
R4938 T7782 T7783 det The,shape
R4939 T7783 T7785 nsubj shape,appeared
R4940 T7784 T7783 amod overall,shape
R4941 T7786 T7783 prep of,shape
R4942 T7787 T7788 nmod mutant,knee
R4943 T7788 T7789 nmod knee,elements
R4944 T7789 T7786 pobj elements,of
R4945 T7790 T7789 amod skeletal,elements
R4946 T7791 T7785 oprd similar,appeared
R4947 T7792 T7791 prep to,similar
R4948 T7793 T7792 pobj controls,to
R4949 T7794 T7785 punct ", ",appeared
R4950 T7795 T7796 mark although,appeared
R4951 T7796 T7785 advcl appeared,appeared
R4952 T7797 T7798 det the,meniscus
R4953 T7798 T7796 nsubj meniscus,appeared
R4954 T7799 T7798 compound fibrocartilaginous,meniscus
R4955 T7800 T7801 dep that,resides
R4956 T7801 T7798 relcl resides,meniscus
R4957 T7802 T7801 prep between,resides
R4958 T7803 T7804 det the,femur
R4959 T7804 T7802 pobj femur,between
R4960 T7805 T7804 cc and,femur
R4961 T7806 T7804 conj tibia,femur
R4962 T7807 T7808 advmod much,less
R4963 T7808 T7809 advmod less,dense
R4964 T7809 T7796 oprd dense,appeared
R4965 T7810 T7796 prep in,appeared
R4966 T7811 T7810 pobj mutants,in
R4967 T7812 T7796 prep at,appeared
R4968 T7813 T7812 pobj E16.5,at
R4969 T7814 T7785 punct .,appeared
R4970 T7816 T7817 det Some,cartilage
R4971 T7817 T7818 nsubj cartilage,formed
R4972 T7819 T7818 prep in,formed
R4973 T7820 T7821 det the,region
R4974 T7821 T7819 pobj region,in
R4975 T7822 T7821 compound meniscus,region
R4976 T7823 T7818 punct ", ",formed
R4977 T7824 T7818 cc but,formed
R4978 T7825 T7826 det the,size
R4979 T7826 T7827 nsubjpass size,reduced
R4980 T7827 T7818 conj reduced,formed
R4981 T7828 T7826 prep of,size
R4982 T7829 T7830 det these,elements
R4983 T7830 T7828 pobj elements,of
R4984 T7831 T7827 auxpass was,reduced
R4985 T7832 T7827 advmod greatly,reduced
R4986 T7833 T7827 cc and,reduced
R4987 T7834 T7827 conj contained,reduced
R4988 T7835 T7836 amod abundant,cells
R4989 T7836 T7834 dobj cells,contained
R4990 T7837 T7836 prep with,cells
R4991 T7838 T7839 amod fibrous,appearance
R4992 T7839 T7837 pobj appearance,with
R4993 T7840 T7839 punct ", ",appearance
R4994 T7841 T7839 amod noncartilaginous,appearance
R4995 T7842 T7843 punct (,data
R4996 T7843 T7834 meta data,contained
R4997 T7844 T7843 amod unpublished,data
R4998 T7845 T7843 punct ),data
R4999 T7846 T7827 punct .,reduced
R5000 T7848 T7849 det This,reduction
R5001 T7849 T7850 nsubjpass reduction,seen
R5002 T7851 T7849 prep of,reduction
R5003 T7852 T7853 det the,meniscus
R5004 T7853 T7851 pobj meniscus,of
R5005 T7854 T7850 aux can,seen
R5006 T7855 T7850 advmod also,seen
R5007 T7856 T7850 auxpass be,seen
R5008 T7857 T7850 prep in,seen
R5009 T7858 T7857 pobj sections,in
R5010 T7859 T7858 prep from,sections
R5011 T7860 T7861 nummod 7,wk
R5012 T7861 T7863 npadvmod wk,old
R5013 T7862 T7861 punct -,wk
R5014 T7863 T7870 amod old,animals
R5015 T7864 T7861 punct -,wk
R5016 T7865 T7861 cc and,wk
R5017 T7866 T7867 nummod 9,mo
R5018 T7867 T7861 conj mo,wk
R5019 T7868 T7867 punct -,mo
R5020 T7869 T7863 punct -,old
R5021 T7870 T7859 pobj animals,from
R5022 T7871 T7872 punct (,arrows
R5023 T7872 T7850 parataxis arrows,seen
R5024 T7873 T7872 dep Figure,arrows
R5025 T7874 T7873 nummod 7E,Figure
R5026 T7875 T7873 punct ", ",Figure
R5027 T7876 T7873 nummod 7H,Figure
R5028 T7877 T7873 punct ", ",Figure
R5029 T7878 T7873 nummod 7K,Figure
R5030 T7879 T7873 punct ", ",Figure
R5031 T7880 T7873 cc and,Figure
R5032 T7881 T7873 conj 7N,Figure
R5033 T7882 T7872 punct ", ",arrows
R5034 T7883 T7872 punct ),arrows
R5035 T7884 T7850 punct .,seen
R5036 T7886 T7887 prep At,flattened
R5037 T7888 T7889 nummod 7,wk
R5038 T7889 T7886 pobj wk,At
R5039 T7890 T7889 prep of,wk
R5040 T7891 T7890 pobj age,of
R5041 T7892 T7893 det the,epiphysis
R5042 T7893 T7887 nsubjpass epiphysis,flattened
R5043 T7894 T7895 advmod normally,domed
R5044 T7895 T7893 amod domed,epiphysis
R5045 T7896 T7893 amod tibial,epiphysis
R5046 T7897 T7887 auxpass was,flattened
R5047 T7898 T7887 cc and,flattened
R5048 T7899 T7887 conj depressed,flattened
R5049 T7900 T7899 prep in,depressed
R5050 T7901 T7902 det the,knees
R5051 T7902 T7900 pobj knees,in
R5052 T7903 T7902 prep of,knees
R5053 T7904 T7905 compound mutant,animals
R5054 T7905 T7903 pobj animals,of
R5055 T7906 T7899 punct ", ",depressed
R5056 T7907 T7908 advmod markedly,reducing
R5057 T7908 T7899 conj reducing,depressed
R5058 T7909 T7910 det the,distance
R5059 T7910 T7908 dobj distance,reducing
R5060 T7911 T7910 prep between,distance
R5061 T7912 T7913 det the,plate
R5062 T7913 T7911 pobj plate,between
R5063 T7914 T7913 compound growth,plate
R5064 T7915 T7913 cc and,plate
R5065 T7916 T7917 amod articular,surface
R5066 T7917 T7913 conj surface,plate
R5067 T7918 T7919 punct (,bar
R5068 T7919 T7908 parataxis bar,reducing
R5069 T7920 T7919 dep Figure,bar
R5070 T7921 T7920 nummod 7E,Figure
R5071 T7922 T7920 cc and,Figure
R5072 T7923 T7920 conj 7H,Figure
R5073 T7924 T7919 punct ", ",bar
R5074 T7925 T7919 amod vertical,bar
R5075 T7926 T7919 punct ),bar
R5076 T7927 T7887 punct .,flattened
R5077 T7929 T7930 amod Articular,cartilage
R5078 T7930 T7931 nsubj cartilage,was
R5079 T7932 T7931 advmod also,was
R5080 T7933 T7931 acomp thinner,was
R5081 T7934 T7933 prep than,thinner
R5082 T7935 T7934 prep in,than
R5083 T7936 T7937 compound control,animals
R5084 T7937 T7935 pobj animals,in
R5085 T7938 T7931 punct ", ",was
R5086 T7939 T7931 conj showed,was
R5087 T7940 T7941 advmod nearly,complete
R5088 T7941 T7942 amod complete,absence
R5089 T7942 T7939 dobj absence,showed
R5090 T7943 T7942 prep of,absence
R5091 T7944 T7945 compound Safranin,O
R5092 T7945 T7946 compound O,staining
R5093 T7946 T7943 pobj staining,of
R5094 T7947 T7939 punct ", ",showed
R5095 T7948 T7939 cc and,showed
R5096 T7949 T7939 conj was,showed
R5097 T7950 T7951 preconj either,acellular
R5098 T7951 T7949 acomp acellular,was
R5099 T7952 T7951 cc or,acellular
R5100 T7953 T7951 conj beginning,acellular
R5101 T7954 T7955 aux to,fibrillate
R5102 T7955 T7953 xcomp fibrillate,beginning
R5103 T7956 T7953 prep in,beginning
R5104 T7957 T7958 amod many,regions
R5105 T7958 T7956 pobj regions,in
R5106 T7959 T7960 punct (,Figure
R5107 T7960 T7949 parataxis Figure,was
R5108 T7961 T7960 nummod 7F,Figure
R5109 T7962 T7960 cc and,Figure
R5110 T7963 T7960 conj 7I,Figure
R5111 T7964 T7960 punct ),Figure
R5112 T7965 T7931 punct .,was
R5113 T7967 T7968 det The,cells
R5114 T7968 T7975 nsubj cells,appeared
R5115 T7969 T7968 amod few,cells
R5116 T7970 T7968 amod large,cells
R5117 T7971 T7972 compound Safranin,O
R5118 T7972 T7973 npadvmod O,stained
R5119 T7973 T7968 amod stained,cells
R5120 T7974 T7973 punct -,stained
R5121 T7976 T7977 advmod still,apparent
R5122 T7977 T7968 relcl apparent,cells
R5123 T7978 T7977 prep in,apparent
R5124 T7979 T7980 nmod mutant,regions
R5125 T7980 T7978 pobj regions,in
R5126 T7981 T7980 amod articular,regions
R5127 T7982 T7983 aux to,correspond
R5128 T7983 T7975 xcomp correspond,appeared
R5129 T7984 T7983 prep in,correspond
R5130 T7985 T7984 pobj position,in
R5131 T7986 T7983 prep to,correspond
R5132 T7987 T7988 amod rare,cells
R5133 T7988 T7986 pobj cells,to
R5134 T7989 T7990 npadvmod LACZ,negative
R5135 T7990 T7988 amod negative,cells
R5136 T7991 T7990 punct -,negative
R5137 T7992 T7988 prep in,cells
R5138 T7993 T7994 amod adjacent,sections
R5139 T7994 T7992 pobj sections,in
R5140 T7995 T7975 punct ", ",appeared
R5141 T7996 T7975 advcl suggesting,appeared
R5142 T7997 T7998 mark that,required
R5143 T7998 T7996 ccomp required,suggesting
R5144 T7999 T7998 nsubjpass Bmpr1a,required
R5145 T8000 T7998 auxpass is,required
R5146 T8001 T8002 npadvmod cell,autonomously
R5147 T8002 T7998 advmod autonomously,required
R5148 T8003 T8002 punct -,autonomously
R5149 T8004 T7998 prep in,required
R5150 T8005 T8006 amod articular,cartilage
R5151 T8006 T8004 pobj cartilage,in
R5152 T8007 T8008 punct (,arrowheads
R5153 T8008 T7975 parataxis arrowheads,appeared
R5154 T8009 T8008 dep Figure,arrowheads
R5155 T8010 T8009 nummod 7I,Figure
R5156 T8011 T8009 cc and,Figure
R5157 T8012 T8009 conj 7J,Figure
R5158 T8013 T8008 punct ", ",arrowheads
R5159 T8014 T8008 amod white,arrowheads
R5160 T8015 T8008 punct ),arrowheads
R5161 T8016 T7975 punct .,appeared
R5162 T8018 T8019 prep By,were
R5163 T8020 T8021 nummod 9,mo
R5164 T8021 T8018 pobj mo,By
R5165 T8022 T8019 punct ", ",were
R5166 T8023 T8024 amod large,areas
R5167 T8024 T8019 nsubj areas,were
R5168 T8025 T8024 prep of,areas
R5169 T8026 T8027 compound mutant,knees
R5170 T8027 T8025 pobj knees,of
R5171 T8028 T8019 acomp devoid,were
R5172 T8029 T8028 prep of,devoid
R5173 T8030 T8031 amod articular,cells
R5174 T8031 T8029 pobj cells,of
R5175 T8032 T8019 punct ", ",were
R5176 T8033 T8019 cc and,were
R5177 T8034 T8035 det the,bones
R5178 T8035 T8036 nsubj bones,appeared
R5179 T8036 T8019 conj appeared,were
R5180 T8037 T8035 prep of,bones
R5181 T8038 T8039 det the,femur
R5182 T8039 T8037 pobj femur,of
R5183 T8040 T8039 cc and,femur
R5184 T8041 T8039 conj tibia,femur
R5185 T8042 T8043 aux to,rub
R5186 T8043 T8036 xcomp rub,appeared
R5187 T8044 T8043 advmod directly,rub
R5188 T8045 T8043 prep against,rub
R5189 T8046 T8047 det each,other
R5190 T8047 T8045 pobj other,against
R5191 T8048 T8036 punct .,appeared
R5192 T8050 T8051 advmod Furthermore,was
R5193 T8052 T8051 punct ", ",was
R5194 T8053 T8054 det the,epiphysis
R5195 T8054 T8051 nsubj epiphysis,was
R5196 T8055 T8054 prep of,epiphysis
R5197 T8056 T8057 det the,tibia
R5198 T8057 T8055 pobj tibia,of
R5199 T8058 T8051 advmod extremely,was
R5200 T8059 T8051 acomp depressed,was
R5201 T8060 T8051 punct ", ",was
R5202 T8061 T8051 prep to,was
R5203 T8062 T8063 det the,point
R5204 T8063 T8061 pobj point,to
R5205 T8064 T8065 mark that,exposed
R5206 T8065 T8063 acl exposed,point
R5207 T8066 T8067 compound growth,cartilage
R5208 T8067 T8065 nsubjpass cartilage,exposed
R5209 T8068 T8067 compound plate,cartilage
R5210 T8069 T8065 auxpass was,exposed
R5211 T8070 T8065 advmod almost,exposed
R5212 T8071 T8065 prep through,exposed
R5213 T8072 T8073 det the,surface
R5214 T8073 T8071 pobj surface,through
R5215 T8074 T8073 prep of,surface
R5216 T8075 T8076 det the,bone
R5217 T8076 T8074 pobj bone,of
R5218 T8077 T8078 punct (,7K
R5219 T8078 T8051 parataxis 7K,was
R5220 T8079 T8078 nmod Figure,7K
R5221 T8080 T8078 punct ", ",7K
R5222 T8081 T8078 conj 7L,7K
R5223 T8082 T8081 punct ", ",7L
R5224 T8083 T8081 conj 7N,7L
R5225 T8084 T8083 punct ", ",7N
R5226 T8085 T8083 cc and,7N
R5227 T8086 T8083 conj 7O,7N
R5228 T8087 T8078 punct ),7K
R5229 T8088 T8051 punct .,was
R5230 T8090 T8091 prep In,showed
R5231 T8092 T8090 pobj addition,In
R5232 T8093 T8091 punct ", ",showed
R5233 T8094 T8091 nsubj mutants,showed
R5234 T8095 T8094 prep at,mutants
R5235 T8096 T8097 nummod 7,wk
R5236 T8097 T8095 pobj wk,at
R5237 T8098 T8097 cc and,wk
R5238 T8099 T8100 nummod 9,mo
R5239 T8100 T8097 conj mo,wk
R5240 T8101 T8102 amod subchondral,sclerosis
R5241 T8102 T8091 dobj sclerosis,showed
R5242 T8103 T8091 punct ", ",showed
R5243 T8104 T8105 advmod especially,in
R5244 T8105 T8091 prep in,showed
R5245 T8106 T8107 det the,epiphysis
R5246 T8107 T8105 pobj epiphysis,in
R5247 T8108 T8107 prep of,epiphysis
R5248 T8109 T8110 det the,femur
R5249 T8110 T8108 pobj femur,of
R5250 T8111 T8112 punct (,asterisks
R5251 T8112 T8091 parataxis asterisks,showed
R5252 T8113 T8114 nmod Figure,7E
R5253 T8114 T8112 dep 7E,asterisks
R5254 T8115 T8114 punct ", ",7E
R5255 T8116 T8114 conj 7H,7E
R5256 T8117 T8116 punct ", ",7H
R5257 T8118 T8116 conj 7K,7H
R5258 T8119 T8118 punct ", ",7K
R5259 T8120 T8118 cc and,7K
R5260 T8121 T8118 conj 7N,7K
R5261 T8122 T8112 punct ", ",asterisks
R5262 T8123 T8112 punct ),asterisks
R5263 T8124 T8091 punct .,showed
R5264 T8126 T8127 mark While,seen
R5265 T8127 T8132 advcl seen,is
R5266 T8128 T8129 amod subchondral,sclerosis
R5267 T8129 T8127 nsubjpass sclerosis,seen
R5268 T8130 T8127 auxpass is,seen
R5269 T8131 T8127 advmod commonly,seen
R5270 T8133 T8127 prep in,seen
R5271 T8134 T8133 pobj cases,in
R5272 T8135 T8134 prep of,cases
R5273 T8136 T8135 pobj osteoarthritis,of
R5274 T8137 T8132 punct ", ",is
R5275 T8138 T8132 nsubj it,is
R5276 T8139 T8132 acomp unclear,is
R5277 T8140 T8132 prep in,is
R5278 T8141 T8142 det this,case
R5279 T8142 T8140 pobj case,in
R5280 T8143 T8144 mark whether,is
R5281 T8144 T8132 advcl is,is
R5282 T8145 T8146 det the,sclerosis
R5283 T8146 T8144 nsubj sclerosis,is
R5284 T8147 T8144 advmod mainly,is
R5285 T8148 T8149 det a,response
R5286 T8149 T8144 attr response,is
R5287 T8150 T8149 prep of,response
R5288 T8151 T8152 compound bone,formation
R5289 T8152 T8150 pobj formation,of
R5290 T8153 T8154 aux to,compensate
R5291 T8154 T8149 advcl compensate,response
R5292 T8155 T8154 prep for,compensate
R5293 T8156 T8157 amod decreased,cartilage
R5294 T8157 T8155 pobj cartilage,for
R5295 T8158 T8157 amod articular,cartilage
R5296 T8159 T8144 punct ", ",is
R5297 T8160 T8144 cc or,is
R5298 T8161 T8162 mark whether,is
R5299 T8162 T8144 conj is,is
R5300 T8163 T8162 nsubj it,is
R5301 T8164 T8165 det the,effect
R5302 T8165 T8162 attr effect,is
R5303 T8166 T8165 prep of,effect
R5304 T8167 T8166 pobj loss,of
R5305 T8168 T8167 prep of,loss
R5306 T8169 T8170 compound Bmpr1a,signaling
R5307 T8170 T8168 pobj signaling,of
R5308 T8171 T8165 prep in,effect
R5309 T8172 T8173 det some,cells
R5310 T8173 T8171 pobj cells,in
R5311 T8174 T8175 npadvmod LACZ,positive
R5312 T8175 T8173 amod positive,cells
R5313 T8176 T8175 punct -,positive
R5314 T8177 T8178 dep that,observed
R5315 T8178 T8173 relcl observed,cells
R5316 T8179 T8178 auxpass are,observed
R5317 T8180 T8178 advmod also,observed
R5318 T8181 T8178 prep in,observed
R5319 T8182 T8183 det these,regions
R5320 T8183 T8181 pobj regions,in
R5321 T8184 T8185 punct (,data
R5322 T8185 T8162 meta data,is
R5323 T8186 T8185 amod unpublished,data
R5324 T8187 T8185 punct ),data
R5325 T8188 T8132 punct .,is
R5326 T8190 T8191 det The,signs
R5327 T8191 T8193 nsubjpass signs,accompanied
R5328 T8192 T8191 amod histological,signs
R5329 T8194 T8191 prep of,signs
R5330 T8195 T8196 compound joint,arthritis
R5331 T8196 T8194 pobj arthritis,of
R5332 T8197 T8193 auxpass were,accompanied
R5333 T8198 T8193 agent by,accompanied
R5334 T8199 T8200 amod functional,impairments
R5335 T8200 T8198 pobj impairments,by
R5336 T8201 T8200 prep in,impairments
R5337 T8202 T8203 preconj both,ability
R5338 T8203 T8201 pobj ability,in
R5339 T8204 T8203 amod grasping,ability
R5340 T8205 T8203 cc and,ability
R5341 T8206 T8203 conj range,ability
R5342 T8207 T8206 prep of,range
R5343 T8208 T8207 pobj motion,of
R5344 T8209 T8193 prep in,accompanied
R5345 T8210 T8211 compound mutant,animals
R5346 T8211 T8209 pobj animals,in
R5347 T8212 T8193 punct .,accompanied
R5348 T8214 T8215 compound Gdf5,Cre
R5349 T8215 T8217 compound Cre,Bmpr1afloxP
R5350 T8216 T8215 punct -,Cre
R5351 T8217 T8219 npadvmod Bmpr1afloxP,mutant
R5352 T8218 T8217 punct /,Bmpr1afloxP
R5353 T8219 T8220 amod mutant,animals
R5354 T8220 T8221 nsubj animals,showed
R5355 T8222 T8223 det a,ability
R5356 T8223 T8221 dobj ability,showed
R5357 T8224 T8225 advmod highly,significantly
R5358 T8225 T8226 advmod significantly,reduced
R5359 T8226 T8223 amod reduced,ability
R5360 T8227 T8228 aux to,grasp
R5361 T8228 T8223 acl grasp,ability
R5362 T8229 T8228 cc and,grasp
R5363 T8230 T8228 conj remain,grasp
R5364 T8231 T8230 oprd suspended,remain
R5365 T8232 T8231 prep on,suspended
R5366 T8233 T8234 det a,rod
R5367 T8234 T8230 dobj rod,remain
R5368 T8235 T8234 amod slender,rod
R5369 T8236 T8237 punct (,time
R5370 T8237 T8221 parataxis time,showed
R5371 T8238 T8237 amod mean,time
R5372 T8239 T8237 compound suspension,time
R5373 T8240 T8237 punct : ,time
R5374 T8241 T8242 nsubj controls,s
R5375 T8242 T8246 dep s,s
R5376 T8243 T8244 quantmod 38,6
R5377 T8244 T8242 nummod 6,s
R5378 T8245 T8244 punct ±,6
R5379 T8246 T8237 dep s,time
R5380 T8247 T8242 punct ", ",s
R5381 T8248 T8249 nsubj n,39
R5382 T8249 T8242 advcl 39,s
R5383 T8250 T8249 punct =,39
R5384 T8251 T8246 punct ;,s
R5385 T8252 T8246 nsubj mutants,s
R5386 T8253 T8254 quantmod 6,3
R5387 T8254 T8246 nummod 3,s
R5388 T8255 T8254 punct ±,3
R5389 T8256 T8246 punct ", ",s
R5390 T8257 T8258 nsubj n,11
R5391 T8258 T8246 advcl 11,s
R5392 T8259 T8258 punct =,11
R5393 T8260 T8246 punct ;,s
R5394 T8261 T8262 nsubj p,0.0001
R5395 T8262 T8246 advcl 0.0001,s
R5396 T8263 T8262 punct <,0.0001
R5397 T8264 T8237 punct ),time
R5398 T8265 T8221 punct .,showed
R5399 T8267 T8268 compound Mutant,mice
R5400 T8268 T8269 nsubj mice,showed
R5401 T8270 T8269 advmod also,showed
R5402 T8271 T8272 det a,decrease
R5403 T8272 T8269 dobj decrease,showed
R5404 T8273 T8272 amod clear,decrease
R5405 T8274 T8272 prep in,decrease
R5406 T8275 T8276 det the,range
R5407 T8276 T8274 pobj range,in
R5408 T8277 T8276 amod maximum,range
R5409 T8278 T8276 prep of,range
R5410 T8279 T8278 pobj mobility,of
R5411 T8280 T8276 prep of,range
R5412 T8281 T8282 nummod two,joints
R5413 T8282 T8280 pobj joints,of
R5414 T8283 T8282 amod different,joints
R5415 T8284 T8282 prep in,joints
R5416 T8285 T8286 det the,digits
R5417 T8286 T8284 pobj digits,in
R5418 T8287 T8269 punct ", ",showed
R5419 T8288 T8289 mark as,assayed
R5420 T8289 T8269 advcl assayed,showed
R5421 T8290 T8289 agent by,assayed
R5422 T8291 T8292 amod passive,manipulation
R5423 T8292 T8290 pobj manipulation,by
R5424 T8293 T8294 punct (,0.05
R5425 T8294 T8269 parataxis 0.05,showed
R5426 T8295 T8296 compound MT,P1
R5427 T8296 T8298 compound P1,joint
R5428 T8297 T8296 punct /,P1
R5429 T8298 T8299 dep joint,0.0003
R5430 T8299 T8294 dep 0.0003,0.05
R5431 T8300 T8299 punct : ,0.0003
R5432 T8301 T8302 dep controls,26
R5433 T8302 T8299 dep 26,0.0003
R5434 T8303 T8304 quantmod 100,0
R5435 T8304 T8306 nummod 0,°
R5436 T8305 T8304 punct ±,0
R5437 T8306 T8302 dep °,26
R5438 T8307 T8302 punct ", ",26
R5439 T8308 T8302 nsubj n,26
R5440 T8309 T8302 punct =,26
R5441 T8310 T8299 punct ;,0.0003
R5442 T8311 T8312 dep mutants,8
R5443 T8312 T8299 dep 8,0.0003
R5444 T8313 T8314 quantmod 82,3
R5445 T8314 T8316 nummod 3,°
R5446 T8315 T8314 punct ±,3
R5447 T8316 T8312 dep °,8
R5448 T8317 T8312 punct ", ",8
R5449 T8318 T8312 nsubj n,8
R5450 T8319 T8312 punct =,8
R5451 T8320 T8299 punct ;,0.0003
R5452 T8321 T8299 nsubj p,0.0003
R5453 T8322 T8299 punct <,0.0003
R5454 T8323 T8294 punct ;,0.05
R5455 T8324 T8325 compound P1,P2
R5456 T8325 T8327 compound P2,joint
R5457 T8326 T8325 punct /,P2
R5458 T8327 T8294 dep joint,0.05
R5459 T8328 T8294 punct : ,0.05
R5460 T8329 T8330 dep controls,23
R5461 T8330 T8294 dep 23,0.05
R5462 T8331 T8332 quantmod 152,1
R5463 T8332 T8334 nummod 1,°
R5464 T8333 T8332 punct ±,1
R5465 T8334 T8330 dep °,23
R5466 T8335 T8330 punct ", ",23
R5467 T8336 T8330 nsubj n,23
R5468 T8337 T8330 punct =,23
R5469 T8338 T8294 punct ;,0.05
R5470 T8339 T8340 dep mutants,6
R5471 T8340 T8294 dep 6,0.05
R5472 T8341 T8342 quantmod 140,5
R5473 T8342 T8344 nummod 5,°
R5474 T8343 T8342 punct ±,5
R5475 T8344 T8340 dep °,6
R5476 T8345 T8340 punct ", ",6
R5477 T8346 T8340 nsubj n,6
R5478 T8347 T8340 punct =,6
R5479 T8348 T8340 punct ;,6
R5480 T8349 T8294 nsubj p,0.05
R5481 T8350 T8294 punct <,0.05
R5482 T8351 T8294 punct ),0.05
R5483 T8352 T8269 punct .,showed
R5484 T8354 T8355 det The,changes
R5485 T8355 T8366 nsubj changes,demonstrate
R5486 T8356 T8355 amod structural,changes
R5487 T8357 T8356 punct ", ",structural
R5488 T8358 T8356 conj histological,structural
R5489 T8359 T8358 punct ", ",histological
R5490 T8360 T8361 compound marker,gene
R5491 T8361 T8362 compound gene,expression
R5492 T8362 T8358 conj expression,histological
R5493 T8363 T8362 punct ", ",expression
R5494 T8364 T8362 cc and,expression
R5495 T8365 T8362 conj functional,expression
R5496 T8367 T8355 prep in,changes
R5497 T8368 T8369 compound mutant,mice
R5498 T8369 T8367 pobj mice,in
R5499 T8370 T8371 mark that,required
R5500 T8371 T8366 ccomp required,demonstrate
R5501 T8372 T8371 nsubjpass BMPR1A,required
R5502 T8373 T8371 auxpass is,required
R5503 T8374 T8371 prep for,required
R5504 T8375 T8376 amod normal,maintenance
R5505 T8376 T8374 pobj maintenance,for
R5506 T8377 T8376 amod postnatal,maintenance
R5507 T8378 T8376 prep of,maintenance
R5508 T8379 T8380 amod articular,cartilage
R5509 T8380 T8378 pobj cartilage,of
R5510 T8381 T8366 punct .,demonstrate

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T7400 3-15 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T7401 32-51 UBERON:0010996 denotes Articular Cartilage
T7402 55-60 UBERON:0002544 denotes Digit
T7403 65-76 UBERON:0001485 denotes Knee Joints
T7404 92-104 UBERON:0004454 denotes ankle region
T7405 158-175 UBERON_EXT:synovial_membrane denotes synovial membrane
T7406 186-192 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7407 193-197 NCBITaxon:10088 denotes mice
T7408 271-280 UBERON:0004905 denotes articular
T7409 339-346 NCBITaxon:33208 denotes animals
T7410 372-375 PR_EXT:000003606 denotes Agg
T7411 380-385 PR_EXT:000005693 denotes Col10
T7413 417-423 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7414 424-433 UBERON:0004905 denotes articular
T7415 449-457 UBERON:0002398 denotes forefeet
T7416 462-470 UBERON:0002387 denotes hindfeet
T7417 514-523 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T7418 595-614 UBERON:0010996 denotes articular cartilage
T7419 692-696 UBERON_EXT:bone_element_or_tissue denotes bone
T7420 760-770 GO:0010467 denotes expression
T7421 774-785 PR_EXT:000030444 denotes Osteocalcin
T7422 787-793 PR_EXT:000003264 denotes Col1a1
T7423 798-804 GO:0031012 denotes matrix
T7424 798-823 PR_EXT:000010473 denotes matrix metalloprotease-13
T7425 805-820 GO_EXT:0008237 denotes metalloprotease
T7426 2600-2608 _FRAGMENT denotes joint of
T7427 2613-2621 UBERON:0003840 denotes hindlimb
T7428 2627-2631 UBERON:0001465 denotes knee
T7429 2689-2700 UBERON:0001487 denotes foot joints
T7430 2706-2713 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T7431 2717-2726 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T7432 2727-2733 GO:0031012 denotes matrix
T7433 2803-2808 UBERON:0004905 denotes joint
T7434 2865-2870 GO:0007567 denotes natal
T7435 2902-2908 PR_EXT:000003266 denotes Col2a1
T7436 2913-2916 PR_EXT:000003606 denotes Agg
T7437 2917-2927 GO:0010467 denotes expression
T7438 2956-2962 SO_EXT:sequence_altered_entity denotes mutant
T7439 2982-2992 GO:0010467 denotes expression
T7440 2996-3000 PR_EXT:000015435 denotes Sox9
T7441 3042-3048 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7442 3049-3053 UBERON:0001465 denotes knee
T7443 3054-3071 UBERON:0004765 denotes skeletal elements
T7444 3115-3133 UBERON:0001995 denotes fibrocartilaginous
T7445 3134-3142 UBERON:0000387 denotes meniscus
T7446 3168-3173 UBERON:0000981 denotes femur
T7447 3178-3183 UBERON:0000979 denotes tibia
T7448 3212-3219 SO_EXT:sequence_altered_entity denotes mutants
T7449 3235-3244 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T7450 3259-3267 UBERON:0000387 denotes meniscus
T7451 3350-3355 CL_GO_EXT:cell denotes cells
T7452 3373-3386 UBERON_EXT:cartilage_element_or_tissue denotes cartilaginous
T7453 3440-3448 UBERON:0000387 denotes meniscus
T7454 3502-3509 NCBITaxon:33208 denotes animals
T7455 3581-3597 UBERON:0004383 denotes tibial epiphysis
T7456 3633-3638 UBERON:0001465 denotes knees
T7457 3642-3648 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7458 3649-3656 NCBITaxon:33208 denotes animals
T7459 3701-3707 GO_EXT:biological_growth_entity_or_process denotes growth
T7460 3701-3713 UBERON:0002516 denotes growth plate
T7461 3718-3727 UBERON:0004905 denotes articular
T7462 3770-3789 UBERON:0010996 denotes Articular cartilage
T7463 3823-3830 NCBITaxon:33208 denotes animals
T7464 3903-3911 CL_GO_EXT:cell denotes cellular
T7465 4008-4013 CL_GO_EXT:cell denotes cells
T7466 4032-4038 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7467 4039-4048 UBERON:0004905 denotes articular
T7468 4100-4104 PR_EXT:000033987 denotes LACZ
T7469 4114-4119 CL_GO_EXT:cell denotes cells
T7470 4158-4164 PR_EXT:000000035 denotes Bmpr1a
T7471 4177-4181 CL_GO_EXT:cell denotes cell
T7472 4198-4217 UBERON:0010996 denotes articular cartilage
T7473 4280-4286 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7474 4287-4292 UBERON:0001465 denotes knees
T7475 4308-4317 UBERON:0004905 denotes articular
T7476 4318-4323 CL_GO_EXT:cell denotes cells
T7477 4333-4338 UBERON:0001474 denotes bones
T7478 4346-4351 UBERON:0000981 denotes femur
T7479 4356-4361 UBERON:0000979 denotes tibia
T7480 4424-4436 _FRAGMENT denotes epiphysis of
T7481 4441-4446 UBERON:0004383 denotes tibia
T7482 4490-4496 GO_EXT:biological_growth_entity_or_process denotes growth
T7483 4490-4512 UBERON:0004129 denotes growth plate cartilage
T7484 4559-4563 UBERON:0001474 denotes bone
T7485 4606-4613 SO_EXT:sequence_altered_entity denotes mutants
T7486 4641-4649 UBERON_EXT:cartilage_element_or_tissue denotes chondral
T7487 4679-4691 _FRAGMENT denotes epiphysis of
T7488 4696-4701 UBERON:0004384 denotes femur
T7489 4751-4759 UBERON_EXT:cartilage_element_or_tissue denotes chondral
T7490 4876-4884 GO_EXT:reaction_or_response denotes response
T7491 4888-4892 UBERON_EXT:bone_element_or_tissue denotes bone
T7492 4888-4902 GO_EXT:bone_development_or_ossification denotes bone formation
T7493 4931-4950 UBERON:0010996 denotes articular cartilage
T7494 4991-4997 PR_EXT:000000035 denotes Bmpr1a
T7495 4998-5007 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T7496 5016-5020 PR_EXT:000033987 denotes LACZ
T7497 5030-5035 CL_GO_EXT:cell denotes cells
T7498 5122-5127 UBERON:0004905 denotes joint
T7499 5219-5225 GO_EXT:biological_movement_or_translocation_process denotes motion
T7500 5229-5235 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7501 5236-5243 NCBITaxon:33208 denotes animals
T7502 5245-5249 PR_EXT:000000281 denotes Gdf5
T7503 5254-5260 PR_EXT:000000035 denotes Bmpr1a
T7504 5260-5265 SO:0000359 denotes floxP
T7505 5266-5272 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7506 5273-5280 NCBITaxon:33208 denotes animals
T7507 5424-5431 SO_EXT:sequence_altered_entity denotes mutants
T7508 5462-5468 SO_EXT:sequence_altered_entity_or_alteration_process denotes Mutant
T7509 5469-5473 NCBITaxon:10088 denotes mice
T7510 5553-5559 UBERON:0004905 denotes joints
T7511 5567-5573 UBERON:0002544 denotes digits
T7512 5611-5613 UBERON:0001448 denotes MT
T7513 5614-5616 UBERON:0004302 denotes P1
T7514 5617-5622 UBERON:0004905 denotes joint
T7515 5651-5658 SO_EXT:sequence_altered_entity denotes mutants
T7516 5687-5689 UBERON:0004302 denotes P1
T7517 5690-5692 UBERON:4100005 denotes P2
T7518 5693-5698 UBERON:0004905 denotes joint
T7519 5727-5734 SO_EXT:sequence_altered_entity denotes mutants
T7520 5793-5799 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T7521 5800-5804 SO_EXT:0000704 denotes gene
T7522 5800-5815 GO:0010467 denotes gene expression
T7523 5843-5849 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T7524 5850-5854 NCBITaxon:10088 denotes mice
T7525 5872-5878 PR_EXT:000000035 denotes BMPR1A
T7526 5906-5911 GO:0007567 denotes natal
T7527 5927-5946 UBERON:0010996 denotes articular cartilage
T7412 386-396 GO:0010467 denotes expression
R4699 T7427 T7426 _lexicallyChainedTo hindlimb,joint of
R4700 T7481 T7480 _lexicallyChainedTo tibia,epiphysis of
R4701 T7488 T7487 _lexicallyChainedTo femur,epiphysis of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T7314 32-51 UBERON:0010996 denotes Articular Cartilage
T7315 55-60 UBERON:0002544 denotes Digit
T7316 65-76 UBERON:0001485 denotes Knee Joints
T7317 92-104 UBERON:0004454 denotes ankle region
T7318 193-197 NCBITaxon:10088 denotes mice
T7319 271-280 UBERON:0004905 denotes articular
T7320 339-346 NCBITaxon:33208 denotes animals
T7321 372-375 PR:000003606 denotes Agg
T7322 380-385 PR:000005693 denotes Col10
T7323 386-396 GO:0010467 denotes expression
T7324 424-433 UBERON:0004905 denotes articular
T7325 449-457 UBERON:0002398 denotes forefeet
T7326 462-470 UBERON:0002387 denotes hindfeet
T7327 595-614 UBERON:0010996 denotes articular cartilage
T7328 760-770 GO:0010467 denotes expression
T7329 774-785 PR:000030444 denotes Osteocalcin
T7330 787-793 PR:000003264 denotes Col1a1
T7331 798-804 GO:0031012 denotes matrix
T7332 798-823 PR:000010473 denotes matrix metalloprotease-13
T7333 2600-2608 _FRAGMENT denotes joint of
T7334 2613-2621 UBERON:0003840 denotes hindlimb
T7335 2627-2631 UBERON:0001465 denotes knee
T7336 2689-2700 UBERON:0001487 denotes foot joints
T7337 2727-2733 GO:0031012 denotes matrix
T7338 2803-2808 UBERON:0004905 denotes joint
T7339 2865-2870 GO:0007567 denotes natal
T7340 2902-2908 PR:000003266 denotes Col2a1
T7341 2913-2916 PR:000003606 denotes Agg
T7342 2917-2927 GO:0010467 denotes expression
T7343 2982-2992 GO:0010467 denotes expression
T7344 2996-3000 PR:000015435 denotes Sox9
T7345 3049-3053 UBERON:0001465 denotes knee
T7346 3054-3071 UBERON:0004765 denotes skeletal elements
T7347 3115-3133 UBERON:0001995 denotes fibrocartilaginous
T7348 3134-3142 UBERON:0000387 denotes meniscus
T7349 3168-3173 UBERON:0000981 denotes femur
T7350 3178-3183 UBERON:0000979 denotes tibia
T7351 3259-3267 UBERON:0000387 denotes meniscus
T7352 3440-3448 UBERON:0000387 denotes meniscus
T7353 3502-3509 NCBITaxon:33208 denotes animals
T7354 3581-3597 UBERON:0004383 denotes tibial epiphysis
T7355 3633-3638 UBERON:0001465 denotes knees
T7356 3649-3656 NCBITaxon:33208 denotes animals
T7357 3701-3713 UBERON:0002516 denotes growth plate
T7358 3718-3727 UBERON:0004905 denotes articular
T7359 3770-3789 UBERON:0010996 denotes Articular cartilage
T7360 3823-3830 NCBITaxon:33208 denotes animals
T7361 4039-4048 UBERON:0004905 denotes articular
T7362 4100-4104 PR:000033987 denotes LACZ
T7363 4158-4164 PR:000000035 denotes Bmpr1a
T7364 4198-4217 UBERON:0010996 denotes articular cartilage
T7365 4287-4292 UBERON:0001465 denotes knees
T7366 4308-4317 UBERON:0004905 denotes articular
T7367 4333-4338 UBERON:0001474 denotes bones
T7368 4346-4351 UBERON:0000981 denotes femur
T7369 4356-4361 UBERON:0000979 denotes tibia
T7370 4424-4436 _FRAGMENT denotes epiphysis of
T7371 4441-4446 UBERON:0004383 denotes tibia
T7372 4490-4512 UBERON:0004129 denotes growth plate cartilage
T7373 4559-4563 UBERON:0001474 denotes bone
T7374 4679-4691 _FRAGMENT denotes epiphysis of
T7375 4696-4701 UBERON:0004384 denotes femur
T7376 4931-4950 UBERON:0010996 denotes articular cartilage
T7377 4991-4997 PR:000000035 denotes Bmpr1a
T7378 5016-5020 PR:000033987 denotes LACZ
T7379 5122-5127 UBERON:0004905 denotes joint
T7380 5236-5243 NCBITaxon:33208 denotes animals
T7381 5245-5249 PR:000000281 denotes Gdf5
T7382 5254-5260 PR:000000035 denotes Bmpr1a
T7383 5260-5265 SO:0000359 denotes floxP
T7384 5273-5280 NCBITaxon:33208 denotes animals
T7385 5469-5473 NCBITaxon:10088 denotes mice
T7386 5553-5559 UBERON:0004905 denotes joints
T7387 5567-5573 UBERON:0002544 denotes digits
T7388 5611-5613 UBERON:0001448 denotes MT
T7389 5614-5616 UBERON:0004302 denotes P1
T7390 5617-5622 UBERON:0004905 denotes joint
T7391 5687-5689 UBERON:0004302 denotes P1
T7392 5690-5692 UBERON:4100005 denotes P2
T7393 5693-5698 UBERON:0004905 denotes joint
T7394 5800-5804 SO:0000704 denotes gene
T7395 5800-5815 GO:0010467 denotes gene expression
T7396 5850-5854 NCBITaxon:10088 denotes mice
T7397 5872-5878 PR:000000035 denotes BMPR1A
T7398 5906-5911 GO:0007567 denotes natal
T7399 5927-5946 UBERON:0010996 denotes articular cartilage
R4696 T7334 T7333 _lexicallyChainedTo hindlimb,joint of
R4697 T7371 T7370 _lexicallyChainedTo tibia,epiphysis of
R4698 T7375 T7374 _lexicallyChainedTo femur,epiphysis of