PMC:523229 / 32737-34030 JSONTXT

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(A and B) LACZ staining (blue) shows Cre-mediated recombination is largely restricted to articular (arrowheads) and synovial cells (asterisks) in both controls and mutants. (C and D) In situ hybridization shows Col10 expression expands in mutants toward regions of synovial membrane expansion and articular surface erosion (brackets and arrows). This may be a cell nonautonomous effect of joint damage, since the LACZ expressing cells at the articular surface do not show upregulation of Col10 (arrowheads) and the region of expanded Col10 expression is largely made up of cells that have not undergone Cre-mediated recombination. Note the formation of a cartilaginous bridge along the joint capsule of the mutant where joint formation is disrupted at earlier stages (B, white arrowhead, and Figure 3, white arrowheads). (A) Scale bar = 75 μm. This synovial hypertrophy is associated with increased numbers of mononuclear cells resembling synoviocytes or macrophages, cell types that are difficult to distinguish even with surface markers at early postnatal stages."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6875","span":{"begin":1077,"end":1085},"obj":"UBERON:0007616"},{"id":"T6876","span":{"begin":1138,"end":1155},"obj":"CL:0000226"},{"id":"T6877","span":{"begin":1142,"end":1149},"obj":"GO:0005634"},{"id":"T6878","span":{"begin":1150,"end":1155},"obj":"CL_GO_EXT:cell"},{"id":"T6879","span":{"begin":1167,"end":1179},"obj":"CL:0000214"},{"id":"T6880","span":{"begin":1183,"end":1194},"obj":"CL:0000235"},{"id":"T6881","span":{"begin":1196,"end":1200},"obj":"CL_GO_EXT:cell"},{"id":"T6882","span":{"begin":1251,"end":1258},"obj":"GO:0009986"},{"id":"T6883","span":{"begin":1259,"end":1266},"obj":"CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag"},{"id":"T6884","span":{"begin":1280,"end":1285},"obj":"GO:0007567"}],"text":"\nFigure 6 Synovial Membrane Expansion, Articular Surface Erosion, and Accelerated Maturation of Underlying Cartilage in Ankles of Bmpr1a Mutant Mice\nNear adjacent sections from the tarsal 2-metatarsal II joint of 7-d-old mice. (A and B) LACZ staining (blue) shows Cre-mediated recombination is largely restricted to articular (arrowheads) and synovial cells (asterisks) in both controls and mutants. (C and D) In situ hybridization shows Col10 expression expands in mutants toward regions of synovial membrane expansion and articular surface erosion (brackets and arrows). This may be a cell nonautonomous effect of joint damage, since the LACZ expressing cells at the articular surface do not show upregulation of Col10 (arrowheads) and the region of expanded Col10 expression is largely made up of cells that have not undergone Cre-mediated recombination. Note the formation of a cartilaginous bridge along the joint capsule of the mutant where joint formation is disrupted at earlier stages (B, white arrowhead, and Figure 3, white arrowheads). (A) Scale bar = 75 μm. This synovial hypertrophy is associated with increased numbers of mononuclear cells resembling synoviocytes or macrophages, cell types that are difficult to distinguish even with surface markers at early postnatal stages."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T6808","span":{"begin":1077,"end":1085},"obj":"UBERON:0007616"},{"id":"T6809","span":{"begin":1138,"end":1155},"obj":"CL:0000226"},{"id":"T6810","span":{"begin":1142,"end":1149},"obj":"GO:0005634"},{"id":"T6811","span":{"begin":1167,"end":1179},"obj":"CL:0000214"},{"id":"T6812","span":{"begin":1183,"end":1194},"obj":"CL:0000235"},{"id":"T6813","span":{"begin":1251,"end":1258},"obj":"GO:0009986"},{"id":"T6814","span":{"begin":1280,"end":1285},"obj":"GO:0007567"}],"text":"\nFigure 6 Synovial Membrane Expansion, Articular Surface Erosion, and Accelerated Maturation of Underlying Cartilage in Ankles of Bmpr1a Mutant Mice\nNear adjacent sections from the tarsal 2-metatarsal II joint of 7-d-old mice. (A and B) LACZ staining (blue) shows Cre-mediated recombination is largely restricted to articular (arrowheads) and synovial cells (asterisks) in both controls and mutants. (C and D) In situ hybridization shows Col10 expression expands in mutants toward regions of synovial membrane expansion and articular surface erosion (brackets and arrows). This may be a cell nonautonomous effect of joint damage, since the LACZ expressing cells at the articular surface do not show upregulation of Col10 (arrowheads) and the region of expanded Col10 expression is largely made up of cells that have not undergone Cre-mediated recombination. Note the formation of a cartilaginous bridge along the joint capsule of the mutant where joint formation is disrupted at earlier stages (B, white arrowhead, and Figure 3, white arrowheads). (A) Scale bar = 75 μm. This synovial hypertrophy is associated with increased numbers of mononuclear cells resembling synoviocytes or macrophages, cell types that are difficult to distinguish even with surface markers at early postnatal stages."}