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PMC:523229 / 31234-34443 JSONTXT

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Id Subject Object Predicate Lexical cue
T6897 0-8 JJ denotes Synovial
T6898 9-20 NN denotes Hypertrophy
T6899 20-22 , denotes ,
T6900 22-31 NN denotes Cartilage
T6901 32-39 NN denotes Erosion
T6902 39-41 , denotes ,
T6903 41-44 CC denotes and
T6904 45-56 VBN denotes Accelerated
T6905 67-77 NN denotes Maturation
T6906 57-66 NN denotes Cartilage
T6907 77-226 sentence denotes Conditional loss of Bmpr1a led to marked hypertrophy of the synovial membrane in the joint capsule of some joints, particularly in the ankle region.
T6908 78-89 JJ denotes Conditional
T6909 90-94 NN denotes loss
T6910 105-108 VBD denotes led
T6911 95-97 IN denotes of
T6912 98-104 NN denotes Bmpr1a
T6913 109-111 IN denotes to
T6914 112-118 VBN denotes marked
T6915 119-130 NN denotes hypertrophy
T6916 131-133 IN denotes of
T6917 134-137 DT denotes the
T6918 147-155 NN denotes membrane
T6919 138-146 JJ denotes synovial
T6920 156-158 IN denotes in
T6921 159-162 DT denotes the
T6922 169-176 NN denotes capsule
T6923 163-168 NN denotes joint
T6924 177-179 IN denotes of
T6925 180-184 DT denotes some
T6926 185-191 NNS denotes joints
T6927 191-193 , denotes ,
T6928 193-205 RB denotes particularly
T6929 206-208 IN denotes in
T6930 209-212 DT denotes the
T6931 219-225 NN denotes region
T6932 213-218 NN denotes ankle
T6933 225-226 . denotes .
T6934 226-435 sentence denotes In the most severely affected joints, the expanded synovial membrane grew into the joint space and was associated with obvious loss or erosion of the articular cartilage (Figure 6A and 6B, asterisks, arrows).
T6935 227-229 IN denotes In
T6936 296-300 VBD denotes grew
T6937 230-233 DT denotes the
T6938 257-263 NNS denotes joints
T6939 234-238 RBS denotes most
T6940 239-247 RB denotes severely
T6941 248-256 VBN denotes affected
T6942 263-265 , denotes ,
T6943 265-268 DT denotes the
T6944 287-295 NN denotes membrane
T6945 269-277 VBN denotes expanded
T6946 278-286 JJ denotes synovial
T6947 301-305 IN denotes into
T6948 306-309 DT denotes the
T6949 316-321 NN denotes space
T6950 310-315 NN denotes joint
T6951 322-325 CC denotes and
T6952 326-329 VBD denotes was
T6953 330-340 VBN denotes associated
T6954 341-345 IN denotes with
T6955 346-353 JJ denotes obvious
T6956 354-358 NN denotes loss
T6957 359-361 CC denotes or
T6958 362-369 NN denotes erosion
T6959 370-372 IN denotes of
T6960 373-376 DT denotes the
T6961 387-396 NN denotes cartilage
T6962 377-386 JJ denotes articular
T6963 397-398 -LRB- denotes (
T6964 427-433 NNS denotes arrows
T6965 398-404 NN denotes Figure
T6966 405-407 CD denotes 6A
T6967 408-411 CC denotes and
T6968 412-414 CD denotes 6B
T6969 414-416 , denotes ,
T6970 416-425 NNS denotes asterisks
T6971 425-427 , denotes ,
T6972 433-434 -RRB- denotes )
T6973 434-435 . denotes .
T6974 435-627 sentence denotes Accelerated cartilage maturation and increased expression of Col10a1 was frequently seen in the chondrocytes underlying the articular erosions (Figure 6C and 6D, brackets) (unpublished data).
T6975 436-447 VBN denotes Accelerated
T6976 458-468 NN denotes maturation
T6977 448-457 NN denotes cartilage
T6978 520-524 VBN denotes seen
T6979 469-472 CC denotes and
T6980 473-482 VBN denotes increased
T6981 483-493 NN denotes expression
T6982 494-496 IN denotes of
T6983 497-504 NN denotes Col10a1
T6984 505-508 VBD denotes was
T6985 509-519 RB denotes frequently
T6986 525-527 IN denotes in
T6987 528-531 DT denotes the
T6988 532-544 NNS denotes chondrocytes
T6989 545-555 VBG denotes underlying
T6990 556-559 DT denotes the
T6991 570-578 NNS denotes erosions
T6992 560-569 JJ denotes articular
T6993 579-580 -LRB- denotes (
T6994 598-606 NNS denotes brackets
T6995 580-586 NN denotes Figure
T6996 587-589 CD denotes 6C
T6997 590-593 CC denotes and
T6998 594-596 CD denotes 6D
T6999 596-598 , denotes ,
T7000 606-607 -RRB- denotes )
T7001 608-609 -LRB- denotes (
T7002 621-625 NNS denotes data
T7003 609-620 JJ denotes unpublished
T7004 625-626 -RRB- denotes )
T7005 626-627 . denotes .
T7006 627-767 sentence denotes Interestingly, the regions of increased Col10a1 expression did not correspond to the regions that had undergone Cre-mediated recombination.
T7007 628-641 RB denotes Interestingly
T7008 695-705 VB denotes correspond
T7009 641-643 , denotes ,
T7010 643-646 DT denotes the
T7011 647-654 NNS denotes regions
T7012 655-657 IN denotes of
T7013 658-667 VBN denotes increased
T7014 676-686 NN denotes expression
T7015 668-675 NN denotes Col10a1
T7016 687-690 VBD denotes did
T7017 691-694 RB denotes not
T7018 706-708 IN denotes to
T7019 709-712 DT denotes the
T7020 713-720 NNS denotes regions
T7021 721-725 WDT denotes that
T7022 730-739 VBN denotes undergone
T7023 726-729 VBD denotes had
T7024 740-743 NN denotes Cre
T7025 744-752 VBN denotes mediated
T7026 743-744 HYPH denotes -
T7027 753-766 NN denotes recombination
T7028 766-767 . denotes .
T7029 767-1106 sentence denotes Instead, increased expression of Col10a1 was seen in a zone of largely LACZ-negative cells stretching from the cartilage adjacent to the ossification front (where Col10a1 is normally expressed in maturing cartilage cells), toward the regions where surface articular cartilage was severely eroded or missing (Figure 6A and 6B, arrowheads).
T7030 768-775 RB denotes Instead
T7031 813-817 VBN denotes seen
T7032 775-777 , denotes ,
T7033 777-786 VBN denotes increased
T7034 787-797 NN denotes expression
T7035 798-800 IN denotes of
T7036 801-808 NN denotes Col10a1
T7037 809-812 VBD denotes was
T7038 818-820 IN denotes in
T7039 821-822 DT denotes a
T7040 823-827 NN denotes zone
T7041 828-830 IN denotes of
T7042 831-838 RB denotes largely
T7043 853-858 NNS denotes cells
T7044 839-843 NN denotes LACZ
T7045 844-852 JJ denotes negative
T7046 843-844 HYPH denotes -
T7047 859-869 VBG denotes stretching
T7048 870-874 IN denotes from
T7049 875-878 DT denotes the
T7050 879-888 NN denotes cartilage
T7051 889-897 JJ denotes adjacent
T7052 898-900 IN denotes to
T7053 901-904 DT denotes the
T7054 918-923 NN denotes front
T7055 905-917 NN denotes ossification
T7056 924-925 -LRB- denotes (
T7057 925-930 WRB denotes where
T7058 951-960 VBN denotes expressed
T7059 931-938 NN denotes Col10a1
T7060 939-941 VBZ denotes is
T7061 942-950 RB denotes normally
T7062 961-963 IN denotes in
T7063 964-972 VBG denotes maturing
T7064 983-988 NNS denotes cells
T7065 973-982 NN denotes cartilage
T7066 988-989 -RRB- denotes )
T7067 989-991 , denotes ,
T7068 991-997 IN denotes toward
T7069 998-1001 DT denotes the
T7070 1002-1009 NNS denotes regions
T7071 1010-1015 WRB denotes where
T7072 1044-1047 VBD denotes was
T7073 1016-1023 NN denotes surface
T7074 1034-1043 NN denotes cartilage
T7075 1024-1033 JJ denotes articular
T7076 1048-1056 RB denotes severely
T7077 1057-1063 VBN denotes eroded
T7078 1064-1066 CC denotes or
T7079 1067-1074 VBG denotes missing
T7080 1075-1076 -LRB- denotes (
T7081 1094-1104 NNS denotes arrowheads
T7082 1076-1082 NN denotes Figure
T7083 1083-1085 CD denotes 6A
T7084 1086-1089 CC denotes and
T7085 1090-1092 CD denotes 6B
T7086 1092-1094 , denotes ,
T7087 1104-1105 -RRB- denotes )
T7088 1105-1106 . denotes .
T7089 1106-1322 sentence denotes Previous studies suggest that parathyroid hormone-related protein, a diffusible signal made in the articular surface, may normally inhibit maturation of underlying cartilage (Vortkamp et al. 1996; Weir et al. 1996).
T7090 1107-1115 JJ denotes Previous
T7091 1116-1123 NNS denotes studies
T7092 1124-1131 VBP denotes suggest
T7093 1132-1136 IN denotes that
T7094 1238-1245 VB denotes inhibit
T7095 1137-1148 NN denotes parathyroid
T7096 1149-1156 NN denotes hormone
T7097 1157-1164 VBN denotes related
T7098 1156-1157 HYPH denotes -
T7099 1165-1172 NN denotes protein
T7100 1172-1174 , denotes ,
T7101 1174-1175 DT denotes a
T7102 1187-1193 NN denotes signal
T7103 1176-1186 JJ denotes diffusible
T7104 1194-1198 VBN denotes made
T7105 1199-1201 IN denotes in
T7106 1202-1205 DT denotes the
T7107 1216-1223 NN denotes surface
T7108 1206-1215 JJ denotes articular
T7109 1223-1225 , denotes ,
T7110 1225-1228 MD denotes may
T7111 1229-1237 RB denotes normally
T7112 1246-1256 NN denotes maturation
T7113 1257-1259 IN denotes of
T7114 1260-1270 VBG denotes underlying
T7115 1271-1280 NN denotes cartilage
T7116 1281-1282 -LRB- denotes (
T7117 1282-1290 NNP denotes Vortkamp
T7118 1291-1293 FW denotes et
T7119 1294-1297 FW denotes al.
T7120 1298-1302 CD denotes 1996
T7121 1302-1303 : denotes ;
T7122 1304-1308 NNP denotes Weir
T7123 1309-1311 FW denotes et
T7124 1312-1315 FW denotes al.
T7125 1316-1320 CD denotes 1996
T7126 1320-1321 -RRB- denotes )
T7127 1321-1322 . denotes .
T7128 1322-1503 sentence denotes Local loss of the articular surface could remove this inhibition and lead to a cell-nonautonomous acceleration of maturation in chondrocytes underlying points of articular erosion.
T7129 1323-1328 JJ denotes Local
T7130 1329-1333 NN denotes loss
T7131 1365-1371 VB denotes remove
T7132 1334-1336 IN denotes of
T7133 1337-1340 DT denotes the
T7134 1351-1358 NN denotes surface
T7135 1341-1350 JJ denotes articular
T7136 1359-1364 MD denotes could
T7137 1372-1376 DT denotes this
T7138 1377-1387 NN denotes inhibition
T7139 1388-1391 CC denotes and
T7140 1392-1396 VBP denotes lead
T7141 1397-1399 IN denotes to
T7142 1400-1401 DT denotes a
T7143 1421-1433 NN denotes acceleration
T7144 1402-1406 NN denotes cell
T7145 1407-1420 JJ denotes nonautonomous
T7146 1406-1407 HYPH denotes -
T7147 1434-1436 IN denotes of
T7148 1437-1447 NN denotes maturation
T7149 1448-1450 IN denotes in
T7150 1451-1463 NNS denotes chondrocytes
T7151 1464-1474 VBG denotes underlying
T7152 1475-1481 NNS denotes points
T7153 1482-1484 IN denotes of
T7154 1485-1494 JJ denotes articular
T7155 1495-1502 NN denotes erosion
T7156 1502-1503 . denotes .
T7157 1503-2796 sentence denotes Figure 6 Synovial Membrane Expansion, Articular Surface Erosion, and Accelerated Maturation of Underlying Cartilage in Ankles of Bmpr1a Mutant Mice Near adjacent sections from the tarsal 2-metatarsal II joint of 7-d-old mice. (A and B) LACZ staining (blue) shows Cre-mediated recombination is largely restricted to articular (arrowheads) and synovial cells (asterisks) in both controls and mutants. (C and D) In situ hybridization shows Col10 expression expands in mutants toward regions of synovial membrane expansion and articular surface erosion (brackets and arrows). This may be a cell nonautonomous effect of joint damage, since the LACZ expressing cells at the articular surface do not show upregulation of Col10 (arrowheads) and the region of expanded Col10 expression is largely made up of cells that have not undergone Cre-mediated recombination. Note the formation of a cartilaginous bridge along the joint capsule of the mutant where joint formation is disrupted at earlier stages (B, white arrowhead, and Figure 3, white arrowheads). (A) Scale bar = 75 μm. This synovial hypertrophy is associated with increased numbers of mononuclear cells resembling synoviocytes or macrophages, cell types that are difficult to distinguish even with surface markers at early postnatal stages.
T7158 2575-2579 DT denotes This
T7159 2589-2600 NN denotes hypertrophy
T7160 2580-2588 JJ denotes synovial
T7161 2604-2614 VBN denotes associated
T7162 2601-2603 VBZ denotes is
T7163 2615-2619 IN denotes with
T7164 2620-2629 VBN denotes increased
T7165 2630-2637 NNS denotes numbers
T7166 2638-2640 IN denotes of
T7167 2641-2652 JJ denotes mononuclear
T7168 2653-2658 NNS denotes cells
T7169 2659-2669 VBG denotes resembling
T7170 2670-2682 NNS denotes synoviocytes
T7171 2683-2685 CC denotes or
T7172 2686-2697 NNS denotes macrophages
T7173 2697-2699 , denotes ,
T7174 2699-2703 NN denotes cell
T7175 2704-2709 NNS denotes types
T7176 2710-2714 WDT denotes that
T7177 2715-2718 VBP denotes are
T7178 2719-2728 JJ denotes difficult
T7179 2729-2731 TO denotes to
T7180 2732-2743 VB denotes distinguish
T7181 2744-2748 RB denotes even
T7182 2749-2753 IN denotes with
T7183 2754-2761 NN denotes surface
T7184 2762-2769 NNS denotes markers
T7185 2770-2772 IN denotes at
T7186 2773-2778 JJ denotes early
T7187 2789-2795 NNS denotes stages
T7188 2779-2788 JJ denotes postnatal
T7189 2795-2796 . denotes .
T7190 2796-2881 sentence denotes However, no neutrophils were observed, suggesting that there is little inflammation.
T7191 2797-2804 RB denotes However
T7192 2826-2834 VBN denotes observed
T7193 2804-2806 , denotes ,
T7194 2806-2808 DT denotes no
T7195 2809-2820 NNS denotes neutrophils
T7196 2821-2825 VBD denotes were
T7197 2834-2836 , denotes ,
T7198 2836-2846 VBG denotes suggesting
T7199 2847-2851 IN denotes that
T7200 2858-2860 VBZ denotes is
T7201 2852-2857 EX denotes there
T7202 2861-2867 JJ denotes little
T7203 2868-2880 NN denotes inflammation
T7204 2880-2881 . denotes .
T7205 2881-2930 sentence denotes At later stages synovial hypertrophy is reduced.
T7206 2882-2884 IN denotes At
T7207 2922-2929 VBN denotes reduced
T7208 2885-2890 JJ denotes later
T7209 2891-2897 NNS denotes stages
T7210 2898-2906 JJ denotes synovial
T7211 2907-2918 NN denotes hypertrophy
T7212 2919-2921 VBZ denotes is
T7213 2929-2930 . denotes .
T7214 2930-3209 sentence denotes Further work will be needed to determine whether synovial development is regulated by BMP signaling, or whether the synovium becomes enlarged as a response to nearby skeletal malformations (such as fusion of the second and central tarsals or defects in the articular cartilage).
T7215 2931-2938 JJ denotes Further
T7216 2939-2943 NN denotes work
T7217 2952-2958 VBN denotes needed
T7218 2944-2948 MD denotes will
T7219 2949-2951 VB denotes be
T7220 2959-2961 TO denotes to
T7221 2962-2971 VB denotes determine
T7222 2972-2979 IN denotes whether
T7223 3004-3013 VBN denotes regulated
T7224 2980-2988 JJ denotes synovial
T7225 2989-3000 NN denotes development
T7226 3001-3003 VBZ denotes is
T7227 3014-3016 IN denotes by
T7228 3017-3020 NN denotes BMP
T7229 3021-3030 NN denotes signaling
T7230 3030-3032 , denotes ,
T7231 3032-3034 CC denotes or
T7232 3035-3042 IN denotes whether
T7233 3056-3063 VBZ denotes becomes
T7234 3043-3046 DT denotes the
T7235 3047-3055 NN denotes synovium
T7236 3064-3072 VBN denotes enlarged
T7237 3073-3075 IN denotes as
T7238 3076-3077 DT denotes a
T7239 3078-3086 NN denotes response
T7240 3087-3089 IN denotes to
T7241 3090-3096 JJ denotes nearby
T7242 3106-3119 NNS denotes malformations
T7243 3097-3105 JJ denotes skeletal
T7244 3120-3121 -LRB- denotes (
T7245 3121-3125 JJ denotes such
T7246 3126-3128 IN denotes as
T7247 3129-3135 NN denotes fusion
T7248 3136-3138 IN denotes of
T7249 3139-3142 DT denotes the
T7250 3162-3169 NNS denotes tarsals
T7251 3143-3149 JJ denotes second
T7252 3150-3153 CC denotes and
T7253 3154-3161 JJ denotes central
T7254 3170-3172 CC denotes or
T7255 3173-3180 NNS denotes defects
T7256 3181-3183 IN denotes in
T7257 3184-3187 DT denotes the
T7258 3198-3207 NN denotes cartilage
T7259 3188-3197 JJ denotes articular
T7260 3207-3208 -RRB- denotes )
T7261 3208-3209 . denotes .
R4354 T6897 T6898 amod Synovial,Hypertrophy
R4355 T6899 T6898 punct ", ",Hypertrophy
R4356 T6900 T6901 compound Cartilage,Erosion
R4357 T6901 T6898 conj Erosion,Hypertrophy
R4358 T6902 T6901 punct ", ",Erosion
R4359 T6903 T6901 cc and,Erosion
R4360 T6904 T6905 amod Accelerated,Maturation
R4361 T6905 T6901 conj Maturation,Erosion
R4362 T6906 T6905 compound Cartilage,Maturation
R4363 T6908 T6909 amod Conditional,loss
R4364 T6909 T6910 nsubj loss,led
R4365 T6911 T6909 prep of,loss
R4366 T6912 T6911 pobj Bmpr1a,of
R4367 T6913 T6910 prep to,led
R4368 T6914 T6915 amod marked,hypertrophy
R4369 T6915 T6913 pobj hypertrophy,to
R4370 T6916 T6915 prep of,hypertrophy
R4371 T6917 T6918 det the,membrane
R4372 T6918 T6916 pobj membrane,of
R4373 T6919 T6918 amod synovial,membrane
R4374 T6920 T6915 prep in,hypertrophy
R4375 T6921 T6922 det the,capsule
R4376 T6922 T6920 pobj capsule,in
R4377 T6923 T6922 compound joint,capsule
R4378 T6924 T6922 prep of,capsule
R4379 T6925 T6926 det some,joints
R4380 T6926 T6924 pobj joints,of
R4381 T6927 T6915 punct ", ",hypertrophy
R4382 T6928 T6929 advmod particularly,in
R4383 T6929 T6915 prep in,hypertrophy
R4384 T6930 T6931 det the,region
R4385 T6931 T6929 pobj region,in
R4386 T6932 T6931 compound ankle,region
R4387 T6933 T6910 punct .,led
R4388 T6935 T6936 prep In,grew
R4389 T6937 T6938 det the,joints
R4390 T6938 T6935 pobj joints,In
R4391 T6939 T6940 advmod most,severely
R4392 T6940 T6941 advmod severely,affected
R4393 T6941 T6938 amod affected,joints
R4394 T6942 T6936 punct ", ",grew
R4395 T6943 T6944 det the,membrane
R4396 T6944 T6936 nsubj membrane,grew
R4397 T6945 T6944 amod expanded,membrane
R4398 T6946 T6944 amod synovial,membrane
R4399 T6947 T6936 prep into,grew
R4400 T6948 T6949 det the,space
R4401 T6949 T6947 pobj space,into
R4402 T6950 T6949 compound joint,space
R4403 T6951 T6936 cc and,grew
R4404 T6952 T6953 auxpass was,associated
R4405 T6953 T6936 conj associated,grew
R4406 T6954 T6953 prep with,associated
R4407 T6955 T6956 amod obvious,loss
R4408 T6956 T6954 pobj loss,with
R4409 T6957 T6956 cc or,loss
R4410 T6958 T6956 conj erosion,loss
R4411 T6959 T6956 prep of,loss
R4412 T6960 T6961 det the,cartilage
R4413 T6961 T6959 pobj cartilage,of
R4414 T6962 T6961 amod articular,cartilage
R4415 T6963 T6964 punct (,arrows
R4416 T6964 T6953 parataxis arrows,associated
R4417 T6965 T6964 dep Figure,arrows
R4418 T6966 T6965 nummod 6A,Figure
R4419 T6967 T6965 cc and,Figure
R4420 T6968 T6965 conj 6B,Figure
R4421 T6969 T6964 punct ", ",arrows
R4422 T6970 T6964 dep asterisks,arrows
R4423 T6971 T6964 punct ", ",arrows
R4424 T6972 T6964 punct ),arrows
R4425 T6973 T6936 punct .,grew
R4426 T6975 T6976 amod Accelerated,maturation
R4427 T6976 T6978 nsubjpass maturation,seen
R4428 T6977 T6976 compound cartilage,maturation
R4429 T6979 T6976 cc and,maturation
R4430 T6980 T6981 amod increased,expression
R4431 T6981 T6976 conj expression,maturation
R4432 T6982 T6981 prep of,expression
R4433 T6983 T6982 pobj Col10a1,of
R4434 T6984 T6978 auxpass was,seen
R4435 T6985 T6978 advmod frequently,seen
R4436 T6986 T6978 prep in,seen
R4437 T6987 T6988 det the,chondrocytes
R4438 T6988 T6986 pobj chondrocytes,in
R4439 T6989 T6988 acl underlying,chondrocytes
R4440 T6990 T6991 det the,erosions
R4441 T6991 T6989 dobj erosions,underlying
R4442 T6992 T6991 amod articular,erosions
R4443 T6993 T6994 punct (,brackets
R4444 T6994 T6978 parataxis brackets,seen
R4445 T6995 T6994 dep Figure,brackets
R4446 T6996 T6995 nummod 6C,Figure
R4447 T6997 T6995 cc and,Figure
R4448 T6998 T6995 conj 6D,Figure
R4449 T6999 T6994 punct ", ",brackets
R4450 T7000 T6994 punct ),brackets
R4451 T7001 T7002 punct (,data
R4452 T7002 T6978 meta data,seen
R4453 T7003 T7002 amod unpublished,data
R4454 T7004 T7002 punct ),data
R4455 T7005 T6978 punct .,seen
R4456 T7007 T7008 advmod Interestingly,correspond
R4457 T7009 T7008 punct ", ",correspond
R4458 T7010 T7011 det the,regions
R4459 T7011 T7008 nsubj regions,correspond
R4460 T7012 T7011 prep of,regions
R4461 T7013 T7014 amod increased,expression
R4462 T7014 T7012 pobj expression,of
R4463 T7015 T7014 compound Col10a1,expression
R4464 T7016 T7008 aux did,correspond
R4465 T7017 T7008 neg not,correspond
R4466 T7018 T7008 prep to,correspond
R4467 T7019 T7020 det the,regions
R4468 T7020 T7018 pobj regions,to
R4469 T7021 T7022 dep that,undergone
R4470 T7022 T7020 relcl undergone,regions
R4471 T7023 T7022 aux had,undergone
R4472 T7024 T7025 npadvmod Cre,mediated
R4473 T7025 T7027 amod mediated,recombination
R4474 T7026 T7025 punct -,mediated
R4475 T7027 T7022 dobj recombination,undergone
R4476 T7028 T7008 punct .,correspond
R4477 T7030 T7031 advmod Instead,seen
R4478 T7032 T7031 punct ", ",seen
R4479 T7033 T7034 amod increased,expression
R4480 T7034 T7031 nsubjpass expression,seen
R4481 T7035 T7034 prep of,expression
R4482 T7036 T7035 pobj Col10a1,of
R4483 T7037 T7031 auxpass was,seen
R4484 T7038 T7031 prep in,seen
R4485 T7039 T7040 det a,zone
R4486 T7040 T7038 pobj zone,in
R4487 T7041 T7040 prep of,zone
R4488 T7042 T7043 advmod largely,cells
R4489 T7043 T7041 pobj cells,of
R4490 T7044 T7045 npadvmod LACZ,negative
R4491 T7045 T7043 amod negative,cells
R4492 T7046 T7045 punct -,negative
R4493 T7047 T7040 acl stretching,zone
R4494 T7048 T7047 prep from,stretching
R4495 T7049 T7050 det the,cartilage
R4496 T7050 T7048 pobj cartilage,from
R4497 T7051 T7050 amod adjacent,cartilage
R4498 T7052 T7051 prep to,adjacent
R4499 T7053 T7054 det the,front
R4500 T7054 T7052 pobj front,to
R4501 T7055 T7054 compound ossification,front
R4502 T7056 T7050 punct (,cartilage
R4503 T7057 T7058 advmod where,expressed
R4504 T7058 T7050 relcl expressed,cartilage
R4505 T7059 T7058 nsubjpass Col10a1,expressed
R4506 T7060 T7058 auxpass is,expressed
R4507 T7061 T7058 advmod normally,expressed
R4508 T7062 T7058 prep in,expressed
R4509 T7063 T7064 amod maturing,cells
R4510 T7064 T7062 pobj cells,in
R4511 T7065 T7064 compound cartilage,cells
R4512 T7066 T7050 punct ),cartilage
R4513 T7067 T7047 punct ", ",stretching
R4514 T7068 T7047 prep toward,stretching
R4515 T7069 T7070 det the,regions
R4516 T7070 T7068 pobj regions,toward
R4517 T7071 T7072 advmod where,was
R4518 T7072 T7070 relcl was,regions
R4519 T7073 T7074 nmod surface,cartilage
R4520 T7074 T7072 nsubj cartilage,was
R4521 T7075 T7074 amod articular,cartilage
R4522 T7076 T7077 advmod severely,eroded
R4523 T7077 T7072 acomp eroded,was
R4524 T7078 T7077 cc or,eroded
R4525 T7079 T7077 conj missing,eroded
R4526 T7080 T7081 punct (,arrowheads
R4527 T7081 T7072 parataxis arrowheads,was
R4528 T7082 T7081 dep Figure,arrowheads
R4529 T7083 T7082 nummod 6A,Figure
R4530 T7084 T7082 cc and,Figure
R4531 T7085 T7082 conj 6B,Figure
R4532 T7086 T7081 punct ", ",arrowheads
R4533 T7087 T7081 punct ),arrowheads
R4534 T7088 T7031 punct .,seen
R4535 T7090 T7091 amod Previous,studies
R4536 T7091 T7092 nsubj studies,suggest
R4537 T7093 T7094 mark that,inhibit
R4538 T7094 T7092 ccomp inhibit,suggest
R4539 T7095 T7096 compound parathyroid,hormone
R4540 T7096 T7097 npadvmod hormone,related
R4541 T7097 T7099 amod related,protein
R4542 T7098 T7097 punct -,related
R4543 T7099 T7094 nsubj protein,inhibit
R4544 T7100 T7099 punct ", ",protein
R4545 T7101 T7102 det a,signal
R4546 T7102 T7099 appos signal,protein
R4547 T7103 T7102 amod diffusible,signal
R4548 T7104 T7102 acl made,signal
R4549 T7105 T7104 prep in,made
R4550 T7106 T7107 det the,surface
R4551 T7107 T7105 pobj surface,in
R4552 T7108 T7107 amod articular,surface
R4553 T7109 T7094 punct ", ",inhibit
R4554 T7110 T7094 aux may,inhibit
R4555 T7111 T7094 advmod normally,inhibit
R4556 T7112 T7094 dobj maturation,inhibit
R4557 T7113 T7112 prep of,maturation
R4558 T7114 T7115 amod underlying,cartilage
R4559 T7115 T7113 pobj cartilage,of
R4560 T7116 T7117 punct (,Vortkamp
R4561 T7117 T7092 meta Vortkamp,suggest
R4562 T7118 T7117 nmod et,Vortkamp
R4563 T7119 T7117 nmod al.,Vortkamp
R4564 T7120 T7117 nummod 1996,Vortkamp
R4565 T7121 T7117 punct ;,Vortkamp
R4566 T7122 T7117 nmod Weir,Vortkamp
R4567 T7123 T7117 nmod et,Vortkamp
R4568 T7124 T7117 nmod al.,Vortkamp
R4569 T7125 T7117 nummod 1996,Vortkamp
R4570 T7126 T7117 punct ),Vortkamp
R4571 T7127 T7092 punct .,suggest
R4572 T7129 T7130 amod Local,loss
R4573 T7130 T7131 nsubj loss,remove
R4574 T7132 T7130 prep of,loss
R4575 T7133 T7134 det the,surface
R4576 T7134 T7132 pobj surface,of
R4577 T7135 T7134 amod articular,surface
R4578 T7136 T7131 aux could,remove
R4579 T7137 T7138 det this,inhibition
R4580 T7138 T7131 dobj inhibition,remove
R4581 T7139 T7131 cc and,remove
R4582 T7140 T7131 conj lead,remove
R4583 T7141 T7140 prep to,lead
R4584 T7142 T7143 det a,acceleration
R4585 T7143 T7141 pobj acceleration,to
R4586 T7144 T7145 npadvmod cell,nonautonomous
R4587 T7145 T7143 amod nonautonomous,acceleration
R4588 T7146 T7145 punct -,nonautonomous
R4589 T7147 T7143 prep of,acceleration
R4590 T7148 T7147 pobj maturation,of
R4591 T7149 T7140 prep in,lead
R4592 T7150 T7149 pobj chondrocytes,in
R4593 T7151 T7150 acl underlying,chondrocytes
R4594 T7152 T7151 dobj points,underlying
R4595 T7153 T7152 prep of,points
R4596 T7154 T7155 amod articular,erosion
R4597 T7155 T7153 pobj erosion,of
R4598 T7156 T7131 punct .,remove
R4599 T7158 T7159 det This,hypertrophy
R4600 T7159 T7161 nsubjpass hypertrophy,associated
R4601 T7160 T7159 amod synovial,hypertrophy
R4602 T7162 T7161 auxpass is,associated
R4603 T7163 T7161 prep with,associated
R4604 T7164 T7165 amod increased,numbers
R4605 T7165 T7163 pobj numbers,with
R4606 T7166 T7165 prep of,numbers
R4607 T7167 T7168 amod mononuclear,cells
R4608 T7168 T7166 pobj cells,of
R4609 T7169 T7168 acl resembling,cells
R4610 T7170 T7169 dobj synoviocytes,resembling
R4611 T7171 T7170 cc or,synoviocytes
R4612 T7172 T7170 conj macrophages,synoviocytes
R4613 T7173 T7170 punct ", ",synoviocytes
R4614 T7174 T7175 compound cell,types
R4615 T7175 T7170 appos types,synoviocytes
R4616 T7176 T7177 dep that,are
R4617 T7177 T7175 relcl are,types
R4618 T7178 T7177 acomp difficult,are
R4619 T7179 T7180 aux to,distinguish
R4620 T7180 T7178 advcl distinguish,difficult
R4621 T7181 T7182 advmod even,with
R4622 T7182 T7180 prep with,distinguish
R4623 T7183 T7184 compound surface,markers
R4624 T7184 T7182 pobj markers,with
R4625 T7185 T7177 prep at,are
R4626 T7186 T7187 amod early,stages
R4627 T7187 T7185 pobj stages,at
R4628 T7188 T7187 amod postnatal,stages
R4629 T7189 T7161 punct .,associated
R4630 T7191 T7192 advmod However,observed
R4631 T7193 T7192 punct ", ",observed
R4632 T7194 T7195 det no,neutrophils
R4633 T7195 T7192 nsubjpass neutrophils,observed
R4634 T7196 T7192 auxpass were,observed
R4635 T7197 T7192 punct ", ",observed
R4636 T7198 T7192 advcl suggesting,observed
R4637 T7199 T7200 mark that,is
R4638 T7200 T7198 ccomp is,suggesting
R4639 T7201 T7200 expl there,is
R4640 T7202 T7203 amod little,inflammation
R4641 T7203 T7200 attr inflammation,is
R4642 T7204 T7192 punct .,observed
R4643 T7206 T7207 prep At,reduced
R4644 T7208 T7209 amod later,stages
R4645 T7209 T7206 pobj stages,At
R4646 T7210 T7211 amod synovial,hypertrophy
R4647 T7211 T7207 nsubjpass hypertrophy,reduced
R4648 T7212 T7207 auxpass is,reduced
R4649 T7213 T7207 punct .,reduced
R4650 T7215 T7216 amod Further,work
R4651 T7216 T7217 nsubjpass work,needed
R4652 T7218 T7217 aux will,needed
R4653 T7219 T7217 auxpass be,needed
R4654 T7220 T7221 aux to,determine
R4655 T7221 T7217 advcl determine,needed
R4656 T7222 T7223 mark whether,regulated
R4657 T7223 T7221 advcl regulated,determine
R4658 T7224 T7225 amod synovial,development
R4659 T7225 T7223 nsubjpass development,regulated
R4660 T7226 T7223 auxpass is,regulated
R4661 T7227 T7223 agent by,regulated
R4662 T7228 T7229 compound BMP,signaling
R4663 T7229 T7227 pobj signaling,by
R4664 T7230 T7223 punct ", ",regulated
R4665 T7231 T7223 cc or,regulated
R4666 T7232 T7233 mark whether,becomes
R4667 T7233 T7223 conj becomes,regulated
R4668 T7234 T7235 det the,synovium
R4669 T7235 T7233 nsubj synovium,becomes
R4670 T7236 T7233 acomp enlarged,becomes
R4671 T7237 T7233 prep as,becomes
R4672 T7238 T7239 det a,response
R4673 T7239 T7237 pobj response,as
R4674 T7240 T7239 prep to,response
R4675 T7241 T7242 amod nearby,malformations
R4676 T7242 T7240 pobj malformations,to
R4677 T7243 T7242 amod skeletal,malformations
R4678 T7244 T7242 punct (,malformations
R4679 T7245 T7246 amod such,as
R4680 T7246 T7242 prep as,malformations
R4681 T7247 T7246 pobj fusion,as
R4682 T7248 T7247 prep of,fusion
R4683 T7249 T7250 det the,tarsals
R4684 T7250 T7248 pobj tarsals,of
R4685 T7251 T7250 amod second,tarsals
R4686 T7252 T7251 cc and,second
R4687 T7253 T7251 conj central,second
R4688 T7254 T7247 cc or,fusion
R4689 T7255 T7247 conj defects,fusion
R4690 T7256 T7255 prep in,defects
R4691 T7257 T7258 det the,cartilage
R4692 T7258 T7256 pobj cartilage,in
R4693 T7259 T7258 amod articular,cartilage
R4694 T7260 T7242 punct ),malformations
R4695 T7261 T7217 punct .,needed

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T6825 0-8 UBERON:0007616 denotes Synovial
T6826 22-31 UBERON_EXT:cartilage_element_or_tissue denotes Cartilage
T6827 57-66 UBERON_EXT:cartilage_element_or_tissue denotes Cartilage
T6828 67-77 GO_PATO_EXT:biological_maturation denotes Maturation
T6829 98-104 PR_EXT:000000035 denotes Bmpr1a
T6830 138-155 UBERON_EXT:synovial_membrane denotes synovial membrane
T6831 163-176 UBERON:0001484 denotes joint capsule
T6832 185-191 UBERON:0004905 denotes joints
T6833 213-225 UBERON:0004454 denotes ankle region
T6834 257-263 UBERON:0004905 denotes joints
T6835 278-295 UBERON_EXT:synovial_membrane denotes synovial membrane
T6836 296-300 GO:0040007 denotes grew
T6837 310-315 UBERON:0004905 denotes joint
T6838 377-396 UBERON:0010996 denotes articular cartilage
T6839 448-457 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T6840 458-468 GO_PATO_EXT:biological_maturation denotes maturation
T6841 483-493 GO:0010467 denotes expression
T6842 497-504 PR_EXT:000005693 denotes Col10a1
T6843 532-544 CL:0000138 denotes chondrocytes
T6844 560-569 UBERON:0004905 denotes articular
T6845 668-675 PR_EXT:000005693 denotes Col10a1
T6846 676-686 GO:0010467 denotes expression
T6847 753-766 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T6848 787-797 GO:0010467 denotes expression
T6849 801-808 PR_EXT:000005693 denotes Col10a1
T6850 839-843 PR_EXT:000033987 denotes LACZ
T6851 853-858 CL_GO_EXT:cell denotes cells
T6852 879-888 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T6853 905-917 GO:0001503 denotes ossification
T6854 905-923 UBERON:0006773 denotes ossification front
T6855 931-938 PR_EXT:000005693 denotes Col10a1
T6856 951-960 GO:0010467 denotes expressed
T6857 964-972 GO_PATO_EXT:biological_maturation denotes maturing
T6858 973-982 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T6859 973-988 CL:0000138 denotes cartilage cells
T6860 983-988 CL_GO_EXT:cell denotes cells
T6861 1024-1043 UBERON:0010996 denotes articular cartilage
T6862 1137-1148 UBERON:0001132 denotes parathyroid
T6863 1137-1156 CHEBI_PR_EXT:parathyroid_hormone denotes parathyroid hormone
T6864 1137-1172 PR_EXT:000013433 denotes parathyroid hormone-related protein
T6865 1149-1156 CHEBI_GO_EXT:hormone denotes hormone
T6866 1165-1172 CHEBI_PR_EXT:protein denotes protein
T6867 1206-1215 UBERON:0004905 denotes articular
T6868 1246-1256 GO_PATO_EXT:biological_maturation denotes maturation
T6869 1271-1280 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T6870 1341-1350 UBERON:0004905 denotes articular
T6871 1402-1406 CL_GO_EXT:cell denotes cell
T6872 1437-1447 GO_PATO_EXT:biological_maturation denotes maturation
T6873 1451-1463 CL:0000138 denotes chondrocytes
T6874 1485-1494 UBERON:0004905 denotes articular
T6875 2580-2588 UBERON:0007616 denotes synovial
T6876 2641-2658 CL:0000226 denotes mononuclear cells
T6877 2645-2652 GO:0005634 denotes nuclear
T6878 2653-2658 CL_GO_EXT:cell denotes cells
T6879 2670-2682 CL:0000214 denotes synoviocytes
T6880 2686-2697 CL:0000235 denotes macrophages
T6881 2699-2703 CL_GO_EXT:cell denotes cell
T6882 2754-2761 GO:0009986 denotes surface
T6883 2762-2769 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6884 2783-2788 GO:0007567 denotes natal
T6885 2809-2820 CL:0000775 denotes neutrophils
T6886 2868-2880 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T6887 2898-2906 UBERON:0007616 denotes synovial
T6888 2980-2988 UBERON:0007616 denotes synovial
T6889 3004-3013 GO:0065007 denotes regulated
T6890 3017-3020 PR_EXT:000000034 denotes BMP
T6891 3017-3030 GO:0030509 denotes BMP signaling
T6892 3047-3055 UBERON:0007616 denotes synovium
T6893 3078-3086 GO_EXT:reaction_or_response denotes response
T6894 3097-3105 UBERON:0004288 denotes skeletal
T6895 3162-3169 UBERON:0001447 denotes tarsals
T6896 3188-3207 UBERON:0010996 denotes articular cartilage

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T6778 0-8 UBERON:0007616 denotes Synovial
T6779 98-104 PR:000000035 denotes Bmpr1a
T6780 163-176 UBERON:0001484 denotes joint capsule
T6781 185-191 UBERON:0004905 denotes joints
T6782 213-225 UBERON:0004454 denotes ankle region
T6783 257-263 UBERON:0004905 denotes joints
T6784 296-300 GO:0040007 denotes grew
T6785 310-315 UBERON:0004905 denotes joint
T6786 377-396 UBERON:0010996 denotes articular cartilage
T6787 483-493 GO:0010467 denotes expression
T6788 497-504 PR:000005693 denotes Col10a1
T6789 532-544 CL:0000138 denotes chondrocytes
T6790 560-569 UBERON:0004905 denotes articular
T6791 668-675 PR:000005693 denotes Col10a1
T6792 676-686 GO:0010467 denotes expression
T6793 787-797 GO:0010467 denotes expression
T6794 801-808 PR:000005693 denotes Col10a1
T6795 839-843 PR:000033987 denotes LACZ
T6796 905-917 GO:0001503 denotes ossification
T6797 905-923 UBERON:0006773 denotes ossification front
T6798 931-938 PR:000005693 denotes Col10a1
T6799 951-960 GO:0010467 denotes expressed
T6800 973-988 CL:0000138 denotes cartilage cells
T6801 1024-1043 UBERON:0010996 denotes articular cartilage
T6802 1137-1148 UBERON:0001132 denotes parathyroid
T6803 1137-1172 PR:000013433 denotes parathyroid hormone-related protein
T6804 1206-1215 UBERON:0004905 denotes articular
T6805 1341-1350 UBERON:0004905 denotes articular
T6806 1451-1463 CL:0000138 denotes chondrocytes
T6807 1485-1494 UBERON:0004905 denotes articular
T6808 2580-2588 UBERON:0007616 denotes synovial
T6809 2641-2658 CL:0000226 denotes mononuclear cells
T6810 2645-2652 GO:0005634 denotes nuclear
T6811 2670-2682 CL:0000214 denotes synoviocytes
T6812 2686-2697 CL:0000235 denotes macrophages
T6813 2754-2761 GO:0009986 denotes surface
T6814 2783-2788 GO:0007567 denotes natal
T6815 2809-2820 CL:0000775 denotes neutrophils
T6816 2898-2906 UBERON:0007616 denotes synovial
T6817 2980-2988 UBERON:0007616 denotes synovial
T6818 3004-3013 GO:0065007 denotes regulated
T6819 3017-3020 PR:000000034 denotes BMP
T6820 3017-3030 GO:0030509 denotes BMP signaling
T6821 3047-3055 UBERON:0007616 denotes synovium
T6822 3097-3105 UBERON:0004288 denotes skeletal
T6823 3162-3169 UBERON:0001447 denotes tarsals
T6824 3188-3207 UBERON:0010996 denotes articular cartilage

2_test

Id Subject Object Predicate Lexical cue
15492776-8662546-84887323 1298-1302 8662546 denotes 1996
15492776-8816783-84887324 1316-1320 8816783 denotes 1996
T52694 1298-1302 8662546 denotes 1996
T50222 1316-1320 8816783 denotes 1996