PMC:523229 / 3079-3718 JSONTXT

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    craft-sa-dev

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Programmed cell death occurs within the interzone, and a three-layered interzone forms that has two layers of higher cell density flanking a region of lower cell density. Non-joint precursors of the skeleton typically develop into cartilage, which hypertrophies and is replaced by bone. However, cells within the high-density layers of the interzone are excluded from this process and develop into the permanent layers of articular cartilage found in the mature joint (Mitrovic 1978)."}

    craft-ca-core-ex-dev

    {"project":"craft-ca-core-ex-dev","denotations":[{"id":"T882","span":{"begin":0,"end":5},"obj":"UBERON:0004905"},{"id":"T883","span":{"begin":30,"end":43},"obj":"GO:0009790"},{"id":"T884","span":{"begin":66,"end":70},"obj":"CL_GO_EXT:cell"},{"id":"T885","span":{"begin":120,"end":128},"obj":"UBERON:0004288"},{"id":"T886","span":{"begin":155,"end":176},"obj":"GO:0012501"},{"id":"T887","span":{"begin":166,"end":170},"obj":"CL_GO_EXT:cell"},{"id":"T888","span":{"begin":272,"end":276},"obj":"CL_GO_EXT:cell"},{"id":"T889","span":{"begin":312,"end":316},"obj":"CL_GO_EXT:cell"},{"id":"T890","span":{"begin":330,"end":335},"obj":"UBERON:0004905"},{"id":"T891","span":{"begin":354,"end":362},"obj":"UBERON:0004288"},{"id":"T892","span":{"begin":386,"end":395},"obj":"UBERON_EXT:cartilage_element_or_tissue"},{"id":"T893","span":{"begin":436,"end":440},"obj":"UBERON_EXT:bone_element_or_tissue"},{"id":"T894","span":{"begin":451,"end":456},"obj":"CL_GO_EXT:cell"},{"id":"T895","span":{"begin":577,"end":596},"obj":"UBERON:0010996"},{"id":"T896","span":{"begin":617,"end":622},"obj":"UBERON:0004905"}],"text":"Joint formation begins during embryogenesis, when stripes of high cell density called interzones form across developing skeletal precursors (Haines 1947). Programmed cell death occurs within the interzone, and a three-layered interzone forms that has two layers of higher cell density flanking a region of lower cell density. Non-joint precursors of the skeleton typically develop into cartilage, which hypertrophies and is replaced by bone. However, cells within the high-density layers of the interzone are excluded from this process and develop into the permanent layers of articular cartilage found in the mature joint (Mitrovic 1978)."}

    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T731","span":{"begin":0,"end":5},"obj":"UBERON:0004905"},{"id":"T732","span":{"begin":30,"end":43},"obj":"GO:0009790"},{"id":"T733","span":{"begin":120,"end":128},"obj":"UBERON:0004288"},{"id":"T734","span":{"begin":155,"end":176},"obj":"GO:0012501"},{"id":"T735","span":{"begin":330,"end":335},"obj":"UBERON:0004905"},{"id":"T736","span":{"begin":354,"end":362},"obj":"UBERON:0004288"},{"id":"T737","span":{"begin":577,"end":596},"obj":"UBERON:0010996"},{"id":"T738","span":{"begin":617,"end":622},"obj":"UBERON:0004905"}],"text":"Joint formation begins during embryogenesis, when stripes of high cell density called interzones form across developing skeletal precursors (Haines 1947). Programmed cell death occurs within the interzone, and a three-layered interzone forms that has two layers of higher cell density flanking a region of lower cell density. Non-joint precursors of the skeleton typically develop into cartilage, which hypertrophies and is replaced by bone. However, cells within the high-density layers of the interzone are excluded from this process and develop into the permanent layers of articular cartilage found in the mature joint (Mitrovic 1978)."}

    2_test

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