PMC:523229 / 25466-26135 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T5895","span":{"begin":0,"end":2},"obj":"IN"},{"id":"T5896","span":{"begin":98,"end":106},"obj":"VBD"},{"id":"T5897","span":{"begin":3,"end":7},"obj":"JJS"},{"id":"T5898","span":{"begin":8,"end":14},"obj":"NNS"},{"id":"T5899","span":{"begin":15,"end":17},"obj":"IN"},{"id":"T5900","span":{"begin":18,"end":24},"obj":"NN"},{"id":"T5901","span":{"begin":37,"end":45},"obj":"NN"},{"id":"T5902","span":{"begin":25,"end":36},"obj":"JJ"},{"id":"T5903","span":{"begin":46,"end":50},"obj":"NNS"},{"id":"T5904","span":{"begin":50,"end":52},"obj":","},{"id":"T5905","span":{"begin":52,"end":61},"obj":"JJ"},{"id":"T5906","span":{"begin":62,"end":74},"obj":"NN"},{"id":"T5907","span":{"begin":75,"end":77},"obj":"IN"},{"id":"T5908","span":{"begin":78,"end":86},"obj":"JJ"},{"id":"T5909","span":{"begin":87,"end":97},"obj":"NNS"},{"id":"T5910","span":{"begin":107,"end":115},"obj":"RB"},{"id":"T5911","span":{"begin":115,"end":116},"obj":"."},{"id":"T5912","span":{"begin":116,"end":388},"obj":"sentence"},{"id":"T5913","span":{"begin":117,"end":125},"obj":"IN"},{"id":"T5914","span":{"begin":162,"end":166},"obj":"VBN"},{"id":"T5915","span":{"begin":126,"end":130},"obj":"NN"},{"id":"T5916","span":{"begin":131,"end":134},"obj":"NN"},{"id":"T5917","span":{"begin":130,"end":131},"obj":"HYPH"},{"id":"T5918","span":{"begin":135,"end":143},"obj":"VBN"},{"id":"T5919","span":{"begin":134,"end":135},"obj":"HYPH"},{"id":"T5920","span":{"begin":144,"end":157},"obj":"NN"},{"id":"T5921","span":{"begin":158,"end":161},"obj":"VBD"},{"id":"T5922","span":{"begin":285,"end":289},"obj":"VBN"},{"id":"T5923","span":{"begin":167,"end":169},"obj":"RB"},{"id":"T5924","span":{"begin":170,"end":175},"obj":"RB"},{"id":"T5925","span":{"begin":176,"end":178},"obj":"IN"},{"id":"T5926","span":{"begin":179,"end":184},"obj":"NN"},{"id":"T5927","span":{"begin":185,"end":187},"obj":"IN"},{"id":"T5928","span":{"begin":188,"end":193},"obj":"NN"},{"id":"T5929","span":{"begin":204,"end":211},"obj":"NNS"},{"id":"T5930","span":{"begin":194,"end":203},"obj":"NN"},{"id":"T5931","span":{"begin":212,"end":213},"obj":"-LRB-"},{"id":"T5932","span":{"begin":213,"end":216},"obj":"VB"},{"id":"T5933","span":{"begin":217,"end":223},"obj":"NN"},{"id":"T5934","span":{"begin":224,"end":226},"obj":"CD"},{"id":"T5935","span":{"begin":226,"end":227},"obj":"-RRB-"},{"id":"T5936","span":{"begin":227,"end":229},"obj":","},{"id":"T5937","span":{"begin":229,"end":231},"obj":"DT"},{"id":"T5938","span":{"begin":232,"end":239},"obj":"NNS"},{"id":"T5939","span":{"begin":240,"end":242},"obj":"IN"},{"id":"T5940","span":{"begin":243,"end":247},"obj":"NN"},{"id":"T5941","span":{"begin":248,"end":253},"obj":"NN"},{"id":"T5942","span":{"begin":254,"end":256},"obj":"CC"},{"id":"T5943","span":{"begin":257,"end":261},"obj":"NN"},{"id":"T5944","span":{"begin":262,"end":275},"obj":"NN"},{"id":"T5945","span":{"begin":276,"end":281},"obj":"MD"},{"id":"T5946","span":{"begin":282,"end":284},"obj":"VB"},{"id":"T5947","span":{"begin":290,"end":292},"obj":"IN"},{"id":"T5948","span":{"begin":293,"end":296},"obj":"DT"},{"id":"T5949","span":{"begin":344,"end":350},"obj":"NNS"},{"id":"T5950","span":{"begin":297,"end":307},"obj":"JJ"},{"id":"T5951","span":{"begin":308,"end":318},"obj":"JJ"},{"id":"T5952","span":{"begin":307,"end":308},"obj":"HYPH"},{"id":"T5953","span":{"begin":319,"end":321},"obj":"CC"},{"id":"T5954","span":{"begin":322,"end":332},"obj":"JJ"},{"id":"T5955","span":{"begin":333,"end":343},"obj":"JJ"},{"id":"T5956","span":{"begin":332,"end":333},"obj":"HYPH"},{"id":"T5957","span":{"begin":351,"end":353},"obj":"IN"},{"id":"T5958","span":{"begin":354,"end":359},"obj":"NN"},{"id":"T5959","span":{"begin":360,"end":362},"obj":"CC"},{"id":"T5960","span":{"begin":363,"end":368},"obj":"NN"},{"id":"T5961","span":{"begin":369,"end":370},"obj":"-LRB-"},{"id":"T5962","span":{"begin":382,"end":386},"obj":"NNS"},{"id":"T5963","span":{"begin":370,"end":381},"obj":"JJ"},{"id":"T5964","span":{"begin":386,"end":387},"obj":"-RRB-"},{"id":"T5965","span":{"begin":387,"end":388},"obj":"."},{"id":"T5966","span":{"begin":388,"end":669},"obj":"sentence"},{"id":"T5967","span":{"begin":389,"end":398},"obj":"RB"},{"id":"T5968","span":{"begin":587,"end":591},"obj":"VBN"},{"id":"T5969","span":{"begin":398,"end":400},"obj":","},{"id":"T5970","span":{"begin":400,"end":408},"obj":"IN"},{"id":"T5971","span":{"begin":435,"end":439},"obj":"VBN"},{"id":"T5972","span":{"begin":409,"end":414},"obj":"JJ"},{"id":"T5973","span":{"begin":420,"end":430},"obj":"NN"},{"id":"T5974","span":{"begin":415,"end":419},"obj":"NN"},{"id":"T5975","span":{"begin":431,"end":434},"obj":"VBD"},{"id":"T5976","span":{"begin":440,"end":442},"obj":"IN"},{"id":"T5977","span":{"begin":443,"end":448},"obj":"NN"},{"id":"T5978","span":{"begin":449,"end":451},"obj":"IN"},{"id":"T5979","span":{"begin":452,"end":467},"obj":"JJ"},{"id":"T5980","span":{"begin":468,"end":474},"obj":"NNS"},{"id":"T5981","span":{"begin":475,"end":478},"obj":"CC"},{"id":"T5982","span":{"begin":479,"end":492},"obj":"JJ"},{"id":"T5983","span":{"begin":493,"end":500},"obj":"NNS"},{"id":"T5984","span":{"begin":501,"end":502},"obj":"-LRB-"},{"id":"T5985","span":{"begin":502,"end":508},"obj":"NN"},{"id":"T5986","span":{"begin":509,"end":511},"obj":"CD"},{"id":"T5987","span":{"begin":511,"end":512},"obj":"-RRB-"},{"id":"T5988","span":{"begin":512,"end":514},"obj":","},{"id":"T5989","span":{"begin":514,"end":516},"obj":"DT"},{"id":"T5990","span":{"begin":517,"end":527},"obj":"NN"},{"id":"T5991","span":{"begin":528,"end":530},"obj":"IN"},{"id":"T5992","span":{"begin":531,"end":541},"obj":"NN"},{"id":"T5993","span":{"begin":542,"end":544},"obj":"CC"},{"id":"T5994","span":{"begin":545,"end":555},"obj":"NN"},{"id":"T5995","span":{"begin":556,"end":558},"obj":"IN"},{"id":"T5996","span":{"begin":559,"end":565},"obj":"NN"},{"id":"T5997","span":{"begin":565,"end":567},"obj":","},{"id":"T5998","span":{"begin":567,"end":571},"obj":"NN"},{"id":"T5999","span":{"begin":571,"end":573},"obj":","},{"id":"T6000","span":{"begin":573,"end":575},"obj":"CC"},{"id":"T6001","span":{"begin":576,"end":582},"obj":"NN"},{"id":"T6002","span":{"begin":583,"end":586},"obj":"VBD"},{"id":"T6003","span":{"begin":592,"end":594},"obj":"IN"},{"id":"T6004","span":{"begin":595,"end":598},"obj":"DT"},{"id":"T6005","span":{"begin":609,"end":616},"obj":"NNS"},{"id":"T6006","span":{"begin":599,"end":608},"obj":"JJ"},{"id":"T6007","span":{"begin":617,"end":619},"obj":"IN"},{"id":"T6008","span":{"begin":620,"end":623},"obj":"DT"},{"id":"T6009","span":{"begin":624,"end":633},"obj":"NNS"},{"id":"T6010","span":{"begin":634,"end":636},"obj":"IN"},{"id":"T6011","span":{"begin":637,"end":642},"obj":"DT"},{"id":"T6012","span":{"begin":643,"end":649},"obj":"NNS"},{"id":"T6013","span":{"begin":650,"end":651},"obj":"-LRB-"},{"id":"T6014","span":{"begin":663,"end":667},"obj":"NNS"},{"id":"T6015","span":{"begin":651,"end":662},"obj":"JJ"},{"id":"T6016","span":{"begin":667,"end":668},"obj":"-RRB-"},{"id":"T6017","span":{"begin":668,"end":669},"obj":"."}],"relations":[{"id":"R3558","pred":"prep","subj":"T5895","obj":"T5896"},{"id":"R3559","pred":"amod","subj":"T5897","obj":"T5898"},{"id":"R3560","pred":"pobj","subj":"T5898","obj":"T5895"},{"id":"R3561","pred":"prep","subj":"T5899","obj":"T5898"},{"id":"R3562","pred":"nmod","subj":"T5900","obj":"T5901"},{"id":"R3563","pred":"compound","subj":"T5901","obj":"T5903"},{"id":"R3564","pred":"amod","subj":"T5902","obj":"T5901"},{"id":"R3565","pred":"pobj","subj":"T5903","obj":"T5899"},{"id":"R3566","pred":"punct","subj":"T5904","obj":"T5896"},{"id":"R3567","pred":"amod","subj":"T5905","obj":"T5906"},{"id":"R3568","pred":"nsubj","subj":"T5906","obj":"T5896"},{"id":"R3569","pred":"prep","subj":"T5907","obj":"T5906"},{"id":"R3570","pred":"amod","subj":"T5908","obj":"T5909"},{"id":"R3571","pred":"pobj","subj":"T5909","obj":"T5907"},{"id":"R3572","pred":"advmod","subj":"T5910","obj":"T5896"},{"id":"R3573","pred":"punct","subj":"T5911","obj":"T5896"},{"id":"R3574","pred":"mark","subj":"T5913","obj":"T5914"},{"id":"R3575","pred":"advcl","subj":"T5914","obj":"T5922"},{"id":"R3576","pred":"compound","subj":"T5915","obj":"T5916"},{"id":"R3577","pred":"npadvmod","subj":"T5916","obj":"T5918"},{"id":"R3578","pred":"punct","subj":"T5917","obj":"T5916"},{"id":"R3579","pred":"amod","subj":"T5918","obj":"T5920"},{"id":"R3580","pred":"punct","subj":"T5919","obj":"T5918"},{"id":"R3581","pred":"nsubjpass","subj":"T5920","obj":"T5914"},{"id":"R3582","pred":"auxpass","subj":"T5921","obj":"T5914"},{"id":"R3583","pred":"advmod","subj":"T5923","obj":"T5924"},{"id":"R3584","pred":"advmod","subj":"T5924","obj":"T5914"},{"id":"R3585","pred":"prep","subj":"T5925","obj":"T5924"},{"id":"R3586","pred":"pobj","subj":"T5926","obj":"T5925"},{"id":"R3587","pred":"prep","subj":"T5927","obj":"T5914"},{"id":"R3588","pred":"compound","subj":"T5928","obj":"T5929"},{"id":"R3589","pred":"pobj","subj":"T5929","obj":"T5927"},{"id":"R3590","pred":"compound","subj":"T5930","obj":"T5929"},{"id":"R3591","pred":"punct","subj":"T5931","obj":"T5932"},{"id":"R3592","pred":"parataxis","subj":"T5932","obj":"T5914"},{"id":"R3593","pred":"dobj","subj":"T5933","obj":"T5932"},{"id":"R3594","pred":"nummod","subj":"T5934","obj":"T5933"},{"id":"R3595","pred":"punct","subj":"T5935","obj":"T5932"},{"id":"R3596","pred":"punct","subj":"T5936","obj":"T5922"},{"id":"R3597","pred":"det","subj":"T5937","obj":"T5938"},{"id":"R3598","pred":"nsubjpass","subj":"T5938","obj":"T5922"},{"id":"R3599","pred":"prep","subj":"T5939","obj":"T5938"},{"id":"R3600","pred":"compound","subj":"T5940","obj":"T5941"},{"id":"R3601","pred":"pobj","subj":"T5941","obj":"T5939"},{"id":"R3602","pred":"cc","subj":"T5942","obj":"T5941"},{"id":"R3603","pred":"compound","subj":"T5943","obj":"T5944"},{"id":"R3604","pred":"conj","subj":"T5944","obj":"T5941"},{"id":"R3605","pred":"aux","subj":"T5945","obj":"T5922"},{"id":"R3606","pred":"auxpass","subj":"T5946","obj":"T5922"},{"id":"R3607","pred":"prep","subj":"T5947","obj":"T5922"},{"id":"R3608","pred":"det","subj":"T5948","obj":"T5949"},{"id":"R3609","pred":"pobj","subj":"T5949","obj":"T5947"},{"id":"R3610","pred":"amod","subj":"T5950","obj":"T5951"},{"id":"R3611","pred":"amod","subj":"T5951","obj":"T5949"},{"id":"R3612","pred":"punct","subj":"T5952","obj":"T5951"},{"id":"R3613","pred":"cc","subj":"T5953","obj":"T5951"},{"id":"R3614","pred":"amod","subj":"T5954","obj":"T5955"},{"id":"R3615","pred":"conj","subj":"T5955","obj":"T5951"},{"id":"R3616","pred":"punct","subj":"T5956","obj":"T5955"},{"id":"R3617","pred":"prep","subj":"T5957","obj":"T5922"},{"id":"R3618","pred":"pobj","subj":"T5958","obj":"T5957"},{"id":"R3619","pred":"cc","subj":"T5959","obj":"T5958"},{"id":"R3620","pred":"conj","subj":"T5960","obj":"T5958"},{"id":"R3621","pred":"punct","subj":"T5961","obj":"T5962"},{"id":"R3622","pred":"meta","subj":"T5962","obj":"T5922"},{"id":"R3623","pred":"amod","subj":"T5963","obj":"T5962"},{"id":"R3624","pred":"punct","subj":"T5964","obj":"T5962"},{"id":"R3625","pred":"punct","subj":"T5965","obj":"T5922"},{"id":"R3626","pred":"advmod","subj":"T5967","obj":"T5968"},{"id":"R3627","pred":"punct","subj":"T5969","obj":"T5968"},{"id":"R3628","pred":"mark","subj":"T5970","obj":"T5971"},{"id":"R3629","pred":"advcl","subj":"T5971","obj":"T5968"},{"id":"R3630","pred":"amod","subj":"T5972","obj":"T5973"},{"id":"R3631","pred":"nsubjpass","subj":"T5973","obj":"T5971"},{"id":"R3632","pred":"compound","subj":"T5974","obj":"T5973"},{"id":"R3633","pred":"auxpass","subj":"T5975","obj":"T5971"},{"id":"R3634","pred":"prep","subj":"T5976","obj":"T5971"},{"id":"R3635","pred":"pobj","subj":"T5977","obj":"T5976"},{"id":"R3636","pred":"prep","subj":"T5978","obj":"T5971"},{"id":"R3637","pred":"amod","subj":"T5979","obj":"T5980"},{"id":"R3638","pred":"pobj","subj":"T5980","obj":"T5978"},{"id":"R3639","pred":"cc","subj":"T5981","obj":"T5980"},{"id":"R3640","pred":"amod","subj":"T5982","obj":"T5983"},{"id":"R3641","pred":"conj","subj":"T5983","obj":"T5980"},{"id":"R3642","pred":"punct","subj":"T5984","obj":"T5985"},{"id":"R3643","pred":"parataxis","subj":"T5985","obj":"T5971"},{"id":"R3644","pred":"nummod","subj":"T5986","obj":"T5985"},{"id":"R3645","pred":"punct","subj":"T5987","obj":"T5985"},{"id":"R3646","pred":"punct","subj":"T5988","obj":"T5968"},{"id":"R3647","pred":"det","subj":"T5989","obj":"T5990"},{"id":"R3648","pred":"nsubjpass","subj":"T5990","obj":"T5968"},{"id":"R3649","pred":"prep","subj":"T5991","obj":"T5990"},{"id":"R3650","pred":"pobj","subj":"T5992","obj":"T5991"},{"id":"R3651","pred":"cc","subj":"T5993","obj":"T5992"},{"id":"R3652","pred":"conj","subj":"T5994","obj":"T5992"},{"id":"R3653","pred":"prep","subj":"T5995","obj":"T5992"},{"id":"R3654","pred":"pobj","subj":"T5996","obj":"T5995"},{"id":"R3655","pred":"punct","subj":"T5997","obj":"T5996"},{"id":"R3656","pred":"conj","subj":"T5998","obj":"T5996"},{"id":"R3657","pred":"punct","subj":"T5999","obj":"T5998"},{"id":"R3658","pred":"cc","subj":"T6000","obj":"T5998"},{"id":"R3659","pred":"conj","subj":"T6001","obj":"T5998"},{"id":"R3660","pred":"auxpass","subj":"T6002","obj":"T5968"},{"id":"R3661","pred":"prep","subj":"T6003","obj":"T5968"},{"id":"R3662","pred":"det","subj":"T6004","obj":"T6005"},{"id":"R3663","pred":"pobj","subj":"T6005","obj":"T6003"},{"id":"R3664","pred":"amod","subj":"T6006","obj":"T6005"},{"id":"R3665","pred":"prep","subj":"T6007","obj":"T6005"},{"id":"R3666","pred":"det","subj":"T6008","obj":"T6009"},{"id":"R3667","pred":"pobj","subj":"T6009","obj":"T6007"},{"id":"R3668","pred":"prep","subj":"T6010","obj":"T5968"},{"id":"R3669","pred":"det","subj":"T6011","obj":"T6012"},{"id":"R3670","pred":"pobj","subj":"T6012","obj":"T6010"},{"id":"R3671","pred":"punct","subj":"T6013","obj":"T6014"},{"id":"R3672","pred":"meta","subj":"T6014","obj":"T5968"},{"id":"R3673","pred":"amod","subj":"T6015","obj":"T6014"},{"id":"R3674","pred":"punct","subj":"T6016","obj":"T6014"},{"id":"R3675","pred":"punct","subj":"T6017","obj":"T5968"}],"text":"In most joints of Bmpr1a conditional knockout mice, embryonic segmentation of skeletal precursors occurred normally. Although Gdf5-Cre-mediated recombination was seen as early as E13.5 in digit interzone regions (see Figure 2C), no changes in cell death or cell proliferation could be seen in the metacarpal-phalangeal or metatarsal-phalangeal joints at E13.5 or E14.5 (unpublished data). Similarly, although clear LACZ expression was seen by E15.5 in interphalangeal joints and periarticular regions (Figure 4D), no difference in morphology or expression of Col2a1, Gdf5, or Bmpr1b was seen in the articular regions of the phalanges at these stages (unpublished data)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T5693","span":{"begin":8,"end":14},"obj":"UBERON:0004905"},{"id":"T5694","span":{"begin":18,"end":24},"obj":"PR_EXT:000000035"},{"id":"T5695","span":{"begin":46,"end":50},"obj":"NCBITaxon:10088"},{"id":"T5696","span":{"begin":52,"end":61},"obj":"UBERON:0000922"},{"id":"T5697","span":{"begin":78,"end":86},"obj":"UBERON:0004288"},{"id":"T5698","span":{"begin":126,"end":130},"obj":"PR_EXT:000000281"},{"id":"T5699","span":{"begin":144,"end":157},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T5700","span":{"begin":188,"end":193},"obj":"UBERON:0002544"},{"id":"T5701","span":{"begin":243,"end":247},"obj":"CL_GO_EXT:cell"},{"id":"T5702","span":{"begin":243,"end":253},"obj":"GO:0008219"},{"id":"T5703","span":{"begin":257,"end":261},"obj":"CL_GO_EXT:cell"},{"id":"T5704","span":{"begin":257,"end":275},"obj":"GO:0008283"},{"id":"T5705","span":{"begin":297,"end":318},"obj":"_FRAGMENT"},{"id":"T5706","span":{"begin":344,"end":350},"obj":"UBERON:0003695"},{"id":"T5707","span":{"begin":322,"end":350},"obj":"UBERON:0003696"},{"id":"T5708","span":{"begin":415,"end":419},"obj":"PR_EXT:000033987"},{"id":"T5709","span":{"begin":420,"end":430},"obj":"GO:0010467"},{"id":"T5710","span":{"begin":452,"end":474},"obj":"UBERON:0006658"},{"id":"T5711","span":{"begin":483,"end":492},"obj":"UBERON:0004905"},{"id":"T5713","span":{"begin":559,"end":565},"obj":"PR_EXT:000003266"},{"id":"T5714","span":{"begin":567,"end":571},"obj":"PR_EXT:000000281"},{"id":"T5715","span":{"begin":576,"end":582},"obj":"PR_EXT:000000036"},{"id":"T5716","span":{"begin":599,"end":608},"obj":"UBERON:0004905"},{"id":"T5717","span":{"begin":624,"end":633},"obj":"UBERON:0003221"},{"id":"T5712","span":{"begin":545,"end":555},"obj":"GO:0010467"}],"relations":[{"id":"R3547","pred":"_lexicallyChainedTo","subj":"T5706","obj":"T5705"}],"text":"In most joints of Bmpr1a conditional knockout mice, embryonic segmentation of skeletal precursors occurred normally. Although Gdf5-Cre-mediated recombination was seen as early as E13.5 in digit interzone regions (see Figure 2C), no changes in cell death or cell proliferation could be seen in the metacarpal-phalangeal or metatarsal-phalangeal joints at E13.5 or E14.5 (unpublished data). Similarly, although clear LACZ expression was seen by E15.5 in interphalangeal joints and periarticular regions (Figure 4D), no difference in morphology or expression of Col2a1, Gdf5, or Bmpr1b was seen in the articular regions of the phalanges at these stages (unpublished data)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T5547","span":{"begin":8,"end":14},"obj":"UBERON:0004905"},{"id":"T5548","span":{"begin":18,"end":24},"obj":"PR:000000035"},{"id":"T5549","span":{"begin":46,"end":50},"obj":"NCBITaxon:10088"},{"id":"T5550","span":{"begin":52,"end":61},"obj":"UBERON:0000922"},{"id":"T5551","span":{"begin":78,"end":86},"obj":"UBERON:0004288"},{"id":"T5552","span":{"begin":126,"end":130},"obj":"PR:000000281"},{"id":"T5553","span":{"begin":188,"end":193},"obj":"UBERON:0002544"},{"id":"T5554","span":{"begin":243,"end":253},"obj":"GO:0008219"},{"id":"T5555","span":{"begin":257,"end":275},"obj":"GO:0008283"},{"id":"T5556","span":{"begin":297,"end":318},"obj":"_FRAGMENT"},{"id":"T5557","span":{"begin":344,"end":350},"obj":"UBERON:0003695"},{"id":"T5558","span":{"begin":322,"end":350},"obj":"UBERON:0003696"},{"id":"T5559","span":{"begin":415,"end":419},"obj":"PR:000033987"},{"id":"T5560","span":{"begin":420,"end":430},"obj":"GO:0010467"},{"id":"T5561","span":{"begin":452,"end":474},"obj":"UBERON:0006658"},{"id":"T5562","span":{"begin":483,"end":492},"obj":"UBERON:0004905"},{"id":"T5563","span":{"begin":545,"end":555},"obj":"GO:0010467"},{"id":"T5564","span":{"begin":559,"end":565},"obj":"PR:000003266"},{"id":"T5565","span":{"begin":567,"end":571},"obj":"PR:000000281"},{"id":"T5566","span":{"begin":576,"end":582},"obj":"PR:000000036"},{"id":"T5567","span":{"begin":599,"end":608},"obj":"UBERON:0004905"},{"id":"T5568","span":{"begin":624,"end":633},"obj":"UBERON:0003221"}],"relations":[{"id":"R3543","pred":"_lexicallyChainedTo","subj":"T5557","obj":"T5556"}],"text":"In most joints of Bmpr1a conditional knockout mice, embryonic segmentation of skeletal precursors occurred normally. Although Gdf5-Cre-mediated recombination was seen as early as E13.5 in digit interzone regions (see Figure 2C), no changes in cell death or cell proliferation could be seen in the metacarpal-phalangeal or metatarsal-phalangeal joints at E13.5 or E14.5 (unpublished data). Similarly, although clear LACZ expression was seen by E15.5 in interphalangeal joints and periarticular regions (Figure 4D), no difference in morphology or expression of Col2a1, Gdf5, or Bmpr1b was seen in the articular regions of the phalanges at these stages (unpublished data)."}