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Id Subject Object Predicate Lexical cue
T3948 0-4 NN denotes Gdf5
T3949 5-8 NN denotes Cre
T3950 4-5 HYPH denotes -
T3951 21-28 NNS denotes Animals
T3952 8-9 HYPH denotes /
T3953 9-20 NN denotes Bmpr1afloxP
T3954 29-36 VBP denotes Survive
T3955 37-39 IN denotes to
T3956 40-49 NN denotes Adulthood
T3957 50-54 IN denotes with
T3958 55-58 NN denotes Ear
T3959 79-86 NNS denotes Defects
T3960 58-60 , denotes ,
T3961 60-67 NN denotes Webbing
T3962 67-69 , denotes ,
T3963 69-72 CC denotes and
T3964 73-78 NN denotes Joint
T3965 86-186 sentence denotes We next used the Gdf5-Cre system to test the role of BMP signaling during normal joint development.
T3966 87-89 PRP denotes We
T3967 95-99 VBD denotes used
T3968 90-94 RB denotes next
T3969 100-103 DT denotes the
T3970 113-119 NN denotes system
T3971 104-108 NN denotes Gdf5
T3972 109-112 NN denotes Cre
T3973 108-109 HYPH denotes -
T3974 120-122 TO denotes to
T3975 123-127 VB denotes test
T3976 128-131 DT denotes the
T3977 132-136 NN denotes role
T3978 137-139 IN denotes of
T3979 140-143 NN denotes BMP
T3980 144-153 NN denotes signaling
T3981 154-160 IN denotes during
T3982 161-167 JJ denotes normal
T3983 174-185 NN denotes development
T3984 168-173 NN denotes joint
T3985 185-186 . denotes .
T3986 186-477 sentence denotes Gdf5-Cre transgenic mice were bred to animals carrying a conditional floxed allele of the Bmpr1a locus (Mishina et al. 2002), usually in the presence of the R26R reporter allele to facilitate simultaneous visualization of Cre-mediated recombination patterns (see typical cross in Figure 3).
T3987 187-191 NN denotes Gdf5
T3988 192-195 NN denotes Cre
T3989 191-192 HYPH denotes -
T3990 207-211 NNS denotes mice
T3991 196-206 JJ denotes transgenic
T3992 217-221 VBN denotes bred
T3993 212-216 VBD denotes were
T3994 222-224 IN denotes to
T3995 225-232 NNS denotes animals
T3996 233-241 VBG denotes carrying
T3997 242-243 DT denotes a
T3998 263-269 NN denotes allele
T3999 244-255 JJ denotes conditional
T4000 256-262 VBN denotes floxed
T4001 270-272 IN denotes of
T4002 273-276 DT denotes the
T4003 284-289 NN denotes locus
T4004 277-283 NN denotes Bmpr1a
T4005 290-291 -LRB- denotes (
T4006 291-298 NNP denotes Mishina
T4007 299-301 FW denotes et
T4008 302-305 FW denotes al.
T4009 306-310 CD denotes 2002
T4010 310-311 -RRB- denotes )
T4011 311-313 , denotes ,
T4012 313-320 RB denotes usually
T4013 321-323 IN denotes in
T4014 324-327 DT denotes the
T4015 328-336 NN denotes presence
T4016 337-339 IN denotes of
T4017 340-343 DT denotes the
T4018 358-364 NN denotes allele
T4019 344-348 NN denotes R26R
T4020 349-357 NN denotes reporter
T4021 365-367 TO denotes to
T4022 368-378 VB denotes facilitate
T4023 379-391 JJ denotes simultaneous
T4024 392-405 NN denotes visualization
T4025 406-408 IN denotes of
T4026 409-412 NN denotes Cre
T4027 413-421 VBN denotes mediated
T4028 412-413 HYPH denotes -
T4029 436-444 NNS denotes patterns
T4030 422-435 NN denotes recombination
T4031 445-446 -LRB- denotes (
T4032 446-449 VB denotes see
T4033 450-457 JJ denotes typical
T4034 458-463 NN denotes cross
T4035 464-466 IN denotes in
T4036 467-473 NN denotes Figure
T4037 474-475 CD denotes 3
T4038 475-476 -RRB- denotes )
T4039 476-477 . denotes .
T4040 477-621 sentence denotes PCR amplification confirmed that a key exon of the Bmpr1a gene was deleted in mice that also carried the Gdf5-Cre transgene (unpublished data).
T4041 478-481 NN denotes PCR
T4042 482-495 NN denotes amplification
T4043 496-505 VBD denotes confirmed
T4044 506-510 IN denotes that
T4045 545-552 VBN denotes deleted
T4046 511-512 DT denotes a
T4047 517-521 NN denotes exon
T4048 513-516 JJ denotes key
T4049 522-524 IN denotes of
T4050 525-528 DT denotes the
T4051 536-540 NN denotes gene
T4052 529-535 NN denotes Bmpr1a
T4053 541-544 VBD denotes was
T4054 553-555 IN denotes in
T4055 556-560 NNS denotes mice
T4056 561-565 WDT denotes that
T4057 571-578 VBD denotes carried
T4058 566-570 RB denotes also
T4059 579-582 DT denotes the
T4060 592-601 NN denotes transgene
T4061 583-587 NN denotes Gdf5
T4062 588-591 NN denotes Cre
T4063 587-588 HYPH denotes -
T4064 602-603 -LRB- denotes (
T4065 615-619 NNS denotes data
T4066 603-614 JJ denotes unpublished
T4067 619-620 -RRB- denotes )
T4068 620-621 . denotes .
T4069 621-790 sentence denotes Previous studies have shown that the recombined Bmpr1afloxP allele mimics a null allele of the Bmpr1a locus when transmitted through the germline (Mishina et al. 2002).
T4070 622-630 JJ denotes Previous
T4071 631-638 NNS denotes studies
T4072 644-649 VBN denotes shown
T4073 639-643 VBP denotes have
T4074 650-654 IN denotes that
T4075 689-695 VBZ denotes mimics
T4076 655-658 DT denotes the
T4077 682-688 NN denotes allele
T4078 659-669 JJ denotes recombined
T4079 670-681 NN denotes Bmpr1afloxP
T4080 696-697 DT denotes a
T4081 703-709 NN denotes allele
T4082 698-702 JJ denotes null
T4083 710-712 IN denotes of
T4084 713-716 DT denotes the
T4085 724-729 NN denotes locus
T4086 717-723 NN denotes Bmpr1a
T4087 730-734 WRB denotes when
T4088 735-746 VBN denotes transmitted
T4089 747-754 IN denotes through
T4090 755-758 DT denotes the
T4091 759-767 NN denotes germline
T4092 768-769 -LRB- denotes (
T4093 769-776 NNP denotes Mishina
T4094 777-779 FW denotes et
T4095 780-783 FW denotes al.
T4096 784-788 CD denotes 2002
T4097 788-789 -RRB- denotes )
T4098 789-790 . denotes .
T4099 790-1049 sentence denotes The Gdf5-Cre/Bmpr1afloxP conditional knockout mice were viable and survived to adulthood, showing that the Gdf5-Cre driver can bypass the early embryonic lethality previously reported in animals with a null mutation in the Bmpr1a locus (Mishina et al. 1995).
T4100 791-794 DT denotes The
T4101 837-841 NNS denotes mice
T4102 795-799 NN denotes Gdf5
T4103 800-803 NN denotes Cre
T4104 799-800 HYPH denotes -
T4105 804-815 NN denotes Bmpr1afloxP
T4106 803-804 HYPH denotes /
T4107 828-836 NN denotes knockout
T4108 816-827 JJ denotes conditional
T4109 842-846 VBD denotes were
T4110 847-853 JJ denotes viable
T4111 854-857 CC denotes and
T4112 858-866 VBD denotes survived
T4113 867-869 IN denotes to
T4114 870-879 NN denotes adulthood
T4115 879-881 , denotes ,
T4116 881-888 VBG denotes showing
T4117 889-893 IN denotes that
T4118 918-924 VB denotes bypass
T4119 894-897 DT denotes the
T4120 907-913 NN denotes driver
T4121 898-902 NN denotes Gdf5
T4122 903-906 NN denotes Cre
T4123 902-903 HYPH denotes -
T4124 914-917 MD denotes can
T4125 925-928 DT denotes the
T4126 945-954 NN denotes lethality
T4127 929-934 JJ denotes early
T4128 935-944 JJ denotes embryonic
T4129 955-965 RB denotes previously
T4130 966-974 VBN denotes reported
T4131 975-977 IN denotes in
T4132 978-985 NNS denotes animals
T4133 986-990 IN denotes with
T4134 991-992 DT denotes a
T4135 998-1006 NN denotes mutation
T4136 993-997 JJ denotes null
T4137 1007-1009 IN denotes in
T4138 1010-1013 DT denotes the
T4139 1021-1026 NN denotes locus
T4140 1014-1020 NN denotes Bmpr1a
T4141 1027-1028 -LRB- denotes (
T4142 1028-1035 NNP denotes Mishina
T4143 1036-1038 FW denotes et
T4144 1039-1042 FW denotes al.
T4145 1043-1047 CD denotes 1995
T4146 1047-1048 -RRB- denotes )
T4147 1048-1049 . denotes .
T4148 1049-1939 sentence denotes Figure 3 Gdf5-Cre-Mediated Deletion of Bmpr1a (A) Breeding strategy simultaneously deletes Bmpr1afloxP and allows visualization of Gdf5-Cre-mediated recombination by lacZ expression from R26R. (B–E) 5-week-old mutant and control mice stained with Alcian blue to mark cartilage and alizarin red to mark bone. (B) Ankle of control with strong blue staining lining each joint (arrowheads). (C) Ankle of mutant showing an absence of blue staining in most regions (arrowheads) and a joint fusion between the central (c) and second (2) tarsals (arrow). (D) Control and (E) mutant metatarsal/phalangeal joint which lacks blue staining in articular regions (arrowheads) but retains staining in the growth plate (asterisks). (F) Control forelimb. (G) Mutant forelimb with webbing between the first and second digit (black arrowhead). The viable Gdf5-Cre/Bmpr1afloxP mice showed several phenotypes.
T4149 1876-1879 DT denotes The
T4150 1908-1912 NNS denotes mice
T4151 1880-1886 JJ denotes viable
T4152 1887-1891 NN denotes Gdf5
T4153 1892-1895 NN denotes Cre
T4154 1891-1892 HYPH denotes -
T4155 1896-1907 NN denotes Bmpr1afloxP
T4156 1895-1896 HYPH denotes /
T4157 1913-1919 VBD denotes showed
T4158 1920-1927 JJ denotes several
T4159 1928-1938 NNS denotes phenotypes
T4160 1938-1939 . denotes .
T4161 1939-2132 sentence denotes First, the conditional knockout mice had shorter ears that often lay flatter against their heads than controls (controls 13.1 ± 0.1 mm long, n = 38; mutants 11.8 ± 0.2 mm, n = 11; p < 0.0001).
T4162 1940-1945 RB denotes First
T4163 1977-1980 VBD denotes had
T4164 1945-1947 , denotes ,
T4165 1947-1950 DT denotes the
T4166 1972-1976 NNS denotes mice
T4167 1951-1962 JJ denotes conditional
T4168 1963-1971 NN denotes knockout
T4169 1981-1988 JJR denotes shorter
T4170 1989-1993 NNS denotes ears
T4171 1994-1998 WDT denotes that
T4172 2005-2008 VBP denotes lay
T4173 1999-2004 RB denotes often
T4174 2009-2016 JJR denotes flatter
T4175 2017-2024 IN denotes against
T4176 2025-2030 PRP$ denotes their
T4177 2031-2036 NNS denotes heads
T4178 2037-2041 IN denotes than
T4179 2042-2050 NNS denotes controls
T4180 2051-2052 -LRB- denotes (
T4181 2124-2130 CD denotes 0.0001
T4182 2052-2060 NNS denotes controls
T4183 2072-2074 NNS denotes mm
T4184 2061-2065 CD denotes 13.1
T4185 2068-2071 CD denotes 0.1
T4186 2066-2067 SYM denotes ±
T4187 2075-2079 RB denotes long
T4188 2079-2081 , denotes ,
T4189 2081-2082 NN denotes n
T4190 2085-2087 CD denotes 38
T4191 2083-2084 SYM denotes =
T4192 2087-2088 : denotes ;
T4193 2089-2096 NNS denotes mutants
T4194 2108-2110 NNS denotes mm
T4195 2097-2101 CD denotes 11.8
T4196 2104-2107 CD denotes 0.2
T4197 2102-2103 SYM denotes ±
T4198 2110-2112 , denotes ,
T4199 2112-2113 NN denotes n
T4200 2116-2118 CD denotes 11
T4201 2114-2115 SYM denotes =
T4202 2118-2119 : denotes ;
T4203 2120-2121 NN denotes p
T4204 2122-2123 SYM denotes <
T4205 2130-2131 -RRB- denotes )
T4206 2131-2132 . denotes .
T4207 2132-2358 sentence denotes BMP signaling is known to be required for growth of the external ear of mice (Kingsley et al. 1992), and this phenotype likely reflects loss of Bmpr1a function in the fraction of ear cells that express the Gdf5-Cre transgene.
T4208 2133-2136 NN denotes BMP
T4209 2137-2146 NN denotes signaling
T4210 2150-2155 VBN denotes known
T4211 2147-2149 VBZ denotes is
T4212 2156-2158 TO denotes to
T4213 2162-2170 VBN denotes required
T4214 2159-2161 VB denotes be
T4215 2171-2174 IN denotes for
T4216 2175-2181 NN denotes growth
T4217 2182-2184 IN denotes of
T4218 2185-2188 DT denotes the
T4219 2198-2201 NN denotes ear
T4220 2189-2197 JJ denotes external
T4221 2202-2204 IN denotes of
T4222 2205-2209 NNS denotes mice
T4223 2210-2211 -LRB- denotes (
T4224 2211-2219 NNP denotes Kingsley
T4225 2220-2222 FW denotes et
T4226 2223-2226 FW denotes al.
T4227 2227-2231 CD denotes 1992
T4228 2231-2232 -RRB- denotes )
T4229 2232-2234 , denotes ,
T4230 2234-2237 CC denotes and
T4231 2238-2242 DT denotes this
T4232 2243-2252 NN denotes phenotype
T4233 2260-2268 VBZ denotes reflects
T4234 2253-2259 RB denotes likely
T4235 2269-2273 NN denotes loss
T4236 2274-2276 IN denotes of
T4237 2277-2283 NN denotes Bmpr1a
T4238 2284-2292 NN denotes function
T4239 2293-2295 IN denotes in
T4240 2296-2299 DT denotes the
T4241 2300-2308 NN denotes fraction
T4242 2309-2311 IN denotes of
T4243 2312-2315 NN denotes ear
T4244 2316-2321 NNS denotes cells
T4245 2322-2326 WDT denotes that
T4246 2327-2334 VBP denotes express
T4247 2335-2338 DT denotes the
T4248 2348-2357 NN denotes transgene
T4249 2339-2343 NN denotes Gdf5
T4250 2344-2347 NN denotes Cre
T4251 2343-2344 HYPH denotes -
T4252 2357-2358 . denotes .
T4253 2358-2624 sentence denotes Most mutant mice also showed soft tissue syndactyly or retention of webbing between the first and second digits of their feet, a phenotype that was more frequent and more severe in the forelimbs (201 of 220, or 91%, of forefeet and 109 of 220, or 50%, of hindfeet).
T4254 2359-2363 JJS denotes Most
T4255 2371-2375 NNS denotes mice
T4256 2364-2370 NN denotes mutant
T4257 2381-2387 VBD denotes showed
T4258 2376-2380 RB denotes also
T4259 2388-2392 JJ denotes soft
T4260 2393-2399 NN denotes tissue
T4261 2400-2410 NN denotes syndactyly
T4262 2411-2413 CC denotes or
T4263 2414-2423 NN denotes retention
T4264 2424-2426 IN denotes of
T4265 2427-2434 NN denotes webbing
T4266 2435-2442 IN denotes between
T4267 2443-2446 DT denotes the
T4268 2464-2470 NNS denotes digits
T4269 2447-2452 JJ denotes first
T4270 2453-2456 CC denotes and
T4271 2457-2463 JJ denotes second
T4272 2471-2473 IN denotes of
T4273 2474-2479 PRP$ denotes their
T4274 2480-2484 NNS denotes feet
T4275 2484-2486 , denotes ,
T4276 2486-2487 DT denotes a
T4277 2488-2497 NN denotes phenotype
T4278 2498-2502 WDT denotes that
T4279 2503-2506 VBD denotes was
T4280 2507-2511 RBR denotes more
T4281 2512-2520 JJ denotes frequent
T4282 2521-2524 CC denotes and
T4283 2525-2529 RBR denotes more
T4284 2530-2536 JJ denotes severe
T4285 2537-2539 IN denotes in
T4286 2540-2543 DT denotes the
T4287 2544-2553 NNS denotes forelimbs
T4288 2554-2555 -LRB- denotes (
T4289 2562-2565 CD denotes 220
T4290 2555-2558 CD denotes 201
T4291 2559-2561 IN denotes of
T4292 2565-2567 , denotes ,
T4293 2567-2569 CC denotes or
T4294 2570-2572 CD denotes 91
T4295 2572-2573 NN denotes %
T4296 2573-2575 , denotes ,
T4297 2575-2577 IN denotes of
T4298 2578-2586 NNS denotes forefeet
T4299 2587-2590 CC denotes and
T4300 2591-2594 CD denotes 109
T4301 2598-2601 CD denotes 220
T4302 2595-2597 IN denotes of
T4303 2601-2603 , denotes ,
T4304 2603-2605 CC denotes or
T4305 2606-2608 CD denotes 50
T4306 2608-2609 NN denotes %
T4307 2609-2611 , denotes ,
T4308 2611-2613 IN denotes of
T4309 2614-2622 NN denotes hindfeet
T4310 2622-2623 -RRB- denotes )
T4311 2623-2624 . denotes .
T4312 2624-2718 sentence denotes Finally, mutant animals showed obvious skeletal changes in whole-mount skeletal preparations.
T4313 2625-2632 RB denotes Finally
T4314 2649-2655 VBD denotes showed
T4315 2632-2634 , denotes ,
T4316 2634-2640 NN denotes mutant
T4317 2641-2648 NNS denotes animals
T4318 2656-2663 JJ denotes obvious
T4319 2673-2680 NNS denotes changes
T4320 2664-2672 JJ denotes skeletal
T4321 2681-2683 IN denotes in
T4322 2684-2689 JJ denotes whole
T4323 2690-2695 NN denotes mount
T4324 2689-2690 HYPH denotes -
T4325 2705-2717 NNS denotes preparations
T4326 2696-2704 JJ denotes skeletal
T4327 2717-2718 . denotes .
T4328 2718-2839 sentence denotes At some sites in the ankles, joints seemed to be missing entirely, with fusion of bones that would normally be separate.
T4329 2719-2721 IN denotes At
T4330 2755-2761 VBD denotes seemed
T4331 2722-2726 DT denotes some
T4332 2727-2732 NNS denotes sites
T4333 2733-2735 IN denotes in
T4334 2736-2739 DT denotes the
T4335 2740-2746 NNS denotes ankles
T4336 2746-2748 , denotes ,
T4337 2748-2754 NNS denotes joints
T4338 2762-2764 TO denotes to
T4339 2765-2767 VB denotes be
T4340 2768-2775 VBG denotes missing
T4341 2776-2784 RB denotes entirely
T4342 2784-2786 , denotes ,
T4343 2786-2790 IN denotes with
T4344 2791-2797 NN denotes fusion
T4345 2798-2800 IN denotes of
T4346 2801-2806 NNS denotes bones
T4347 2807-2811 WDT denotes that
T4348 2827-2829 VB denotes be
T4349 2812-2817 MD denotes would
T4350 2818-2826 RB denotes normally
T4351 2830-2838 JJ denotes separate
T4352 2838-2839 . denotes .
T4353 2839-3042 sentence denotes For example, the second distal tarsal was fused to the central tarsal bone in every conditional knockout animal examined (18 of 18), a phenotype not observed in controls (zero of 18) (Figure 3B and 3C).
T4354 2840-2843 IN denotes For
T4355 2882-2887 VBN denotes fused
T4356 2844-2851 NN denotes example
T4357 2851-2853 , denotes ,
T4358 2853-2856 DT denotes the
T4359 2871-2877 JJ denotes tarsal
T4360 2857-2863 JJ denotes second
T4361 2864-2870 JJ denotes distal
T4362 2878-2881 VBD denotes was
T4363 2888-2890 IN denotes to
T4364 2891-2894 DT denotes the
T4365 2910-2914 NN denotes bone
T4366 2895-2902 JJ denotes central
T4367 2903-2909 JJ denotes tarsal
T4368 2915-2917 IN denotes in
T4369 2918-2923 DT denotes every
T4370 2945-2951 NN denotes animal
T4371 2924-2935 JJ denotes conditional
T4372 2936-2944 NN denotes knockout
T4373 2952-2960 VBN denotes examined
T4374 2961-2962 -LRB- denotes (
T4375 2968-2970 CD denotes 18
T4376 2962-2964 CD denotes 18
T4377 2965-2967 IN denotes of
T4378 2970-2971 -RRB- denotes )
T4379 2971-2973 , denotes ,
T4380 2973-2974 DT denotes a
T4381 2975-2984 NN denotes phenotype
T4382 2985-2988 RB denotes not
T4383 2989-2997 VBN denotes observed
T4384 2998-3000 IN denotes in
T4385 3001-3009 NNS denotes controls
T4386 3010-3011 -LRB- denotes (
T4387 3019-3021 CD denotes 18
T4388 3011-3015 CD denotes zero
T4389 3016-3018 IN denotes of
T4390 3021-3022 -RRB- denotes )
T4391 3023-3024 -LRB- denotes (
T4392 3024-3030 NN denotes Figure
T4393 3031-3033 CD denotes 3B
T4394 3034-3037 CC denotes and
T4395 3038-3040 CD denotes 3C
T4396 3040-3041 -RRB- denotes )
T4397 3041-3042 . denotes .
T4398 3042-3205 sentence denotes At other locations, joints had clearly formed but showed dramatic loss of staining with the cartilage matrix marker Alcian blue (Figure 3B–3E) (unpublished data).
T4399 3043-3045 IN denotes At
T4400 3082-3088 VBN denotes formed
T4401 3046-3051 JJ denotes other
T4402 3052-3061 NNS denotes locations
T4403 3061-3063 , denotes ,
T4404 3063-3069 NNS denotes joints
T4405 3070-3073 VBD denotes had
T4406 3074-3081 RB denotes clearly
T4407 3089-3092 CC denotes but
T4408 3093-3099 VBD denotes showed
T4409 3100-3108 JJ denotes dramatic
T4410 3109-3113 NN denotes loss
T4411 3114-3116 IN denotes of
T4412 3117-3125 NN denotes staining
T4413 3126-3130 IN denotes with
T4414 3131-3134 DT denotes the
T4415 3152-3158 NN denotes marker
T4416 3135-3144 NN denotes cartilage
T4417 3145-3151 NN denotes matrix
T4418 3159-3165 JJ denotes Alcian
T4419 3166-3170 NN denotes blue
T4420 3171-3172 -LRB- denotes (
T4421 3179-3181 NN denotes 3B
T4422 3172-3178 NN denotes Figure
T4423 3181-3182 SYM denotes –
T4424 3182-3184 NN denotes 3E
T4425 3184-3185 -RRB- denotes )
T4426 3186-3187 -LRB- denotes (
T4427 3199-3203 NNS denotes data
T4428 3187-3198 JJ denotes unpublished
T4429 3203-3204 -RRB- denotes )
T4430 3204-3205 . denotes .
T4431 3205-3337 sentence denotes Normal Alcian blue staining was seen in non-articular regions, such as the cartilaginous growth plate (Figure 3D and 3E, asterisk).
T4432 3206-3212 JJ denotes Normal
T4433 3225-3233 NN denotes staining
T4434 3213-3219 JJ denotes Alcian
T4435 3220-3224 NN denotes blue
T4436 3238-3242 VBN denotes seen
T4437 3234-3237 VBD denotes was
T4438 3243-3245 IN denotes in
T4439 3246-3259 JJ denotes non-articular
T4440 3260-3267 NNS denotes regions
T4441 3267-3269 , denotes ,
T4442 3269-3273 JJ denotes such
T4443 3274-3276 IN denotes as
T4444 3277-3280 DT denotes the
T4445 3302-3307 NN denotes plate
T4446 3281-3294 JJ denotes cartilaginous
T4447 3295-3301 NN denotes growth
T4448 3308-3309 -LRB- denotes (
T4449 3327-3335 NN denotes asterisk
T4450 3309-3315 NN denotes Figure
T4451 3316-3318 CD denotes 3D
T4452 3319-3322 CC denotes and
T4453 3323-3325 CD denotes 3E
T4454 3325-3327 , denotes ,
T4455 3335-3336 -RRB- denotes )
T4456 3336-3337 . denotes .
T4457 3337-3544 sentence denotes These data suggest that Bmpr1a function is required for the formation of specific joints in the ankle region and for either generation or maintenance of articular cartilage in most other joints of the limb.
T4458 3338-3343 DT denotes These
T4459 3344-3348 NNS denotes data
T4460 3349-3356 VBP denotes suggest
T4461 3357-3361 IN denotes that
T4462 3378-3380 VBZ denotes is
T4463 3362-3368 NN denotes Bmpr1a
T4464 3369-3377 NN denotes function
T4465 3381-3389 VBN denotes required
T4466 3390-3393 IN denotes for
T4467 3394-3397 DT denotes the
T4468 3398-3407 NN denotes formation
T4469 3408-3410 IN denotes of
T4470 3411-3419 JJ denotes specific
T4471 3420-3426 NNS denotes joints
T4472 3427-3429 IN denotes in
T4473 3430-3433 DT denotes the
T4474 3440-3446 NN denotes region
T4475 3434-3439 NN denotes ankle
T4476 3447-3450 CC denotes and
T4477 3451-3454 IN denotes for
T4478 3455-3461 CC denotes either
T4479 3462-3472 NN denotes generation
T4480 3473-3475 CC denotes or
T4481 3476-3487 NN denotes maintenance
T4482 3488-3490 IN denotes of
T4483 3491-3500 JJ denotes articular
T4484 3501-3510 NN denotes cartilage
T4485 3511-3513 IN denotes in
T4486 3514-3518 JJS denotes most
T4487 3525-3531 NNS denotes joints
T4488 3519-3524 JJ denotes other
T4489 3532-3534 IN denotes of
T4490 3535-3538 DT denotes the
T4491 3539-3543 NN denotes limb
T4492 3543-3544 . denotes .
R2414 T3948 T3949 nmod Gdf5,Cre
R2415 T3949 T3951 nmod Cre,Animals
R2416 T3950 T3949 punct -,Cre
R2417 T3951 T3954 nsubj Animals,Survive
R2418 T3952 T3949 punct /,Cre
R2419 T3953 T3949 appos Bmpr1afloxP,Cre
R2420 T3955 T3954 prep to,Survive
R2421 T3956 T3955 pobj Adulthood,to
R2422 T3957 T3954 prep with,Survive
R2423 T3958 T3959 nmod Ear,Defects
R2424 T3959 T3957 pobj Defects,with
R2425 T3960 T3958 punct ", ",Ear
R2426 T3961 T3958 conj Webbing,Ear
R2427 T3962 T3961 punct ", ",Webbing
R2428 T3963 T3961 cc and,Webbing
R2429 T3964 T3961 conj Joint,Webbing
R2430 T3966 T3967 nsubj We,used
R2431 T3968 T3967 advmod next,used
R2432 T3969 T3970 det the,system
R2433 T3970 T3967 dobj system,used
R2434 T3971 T3972 compound Gdf5,Cre
R2435 T3972 T3970 compound Cre,system
R2436 T3973 T3972 punct -,Cre
R2437 T3974 T3975 aux to,test
R2438 T3975 T3967 advcl test,used
R2439 T3976 T3977 det the,role
R2440 T3977 T3975 dobj role,test
R2441 T3978 T3977 prep of,role
R2442 T3979 T3980 compound BMP,signaling
R2443 T3980 T3978 pobj signaling,of
R2444 T3981 T3975 prep during,test
R2445 T3982 T3983 amod normal,development
R2446 T3983 T3981 pobj development,during
R2447 T3984 T3983 compound joint,development
R2448 T3985 T3967 punct .,used
R2449 T3987 T3988 nmod Gdf5,Cre
R2450 T3988 T3990 nmod Cre,mice
R2451 T3989 T3988 punct -,Cre
R2452 T3990 T3992 nsubjpass mice,bred
R2453 T3991 T3990 amod transgenic,mice
R2454 T3993 T3992 auxpass were,bred
R2455 T3994 T3992 prep to,bred
R2456 T3995 T3994 pobj animals,to
R2457 T3996 T3995 acl carrying,animals
R2458 T3997 T3998 det a,allele
R2459 T3998 T3996 dobj allele,carrying
R2460 T3999 T3998 amod conditional,allele
R2461 T4000 T3998 amod floxed,allele
R2462 T4001 T3998 prep of,allele
R2463 T4002 T4003 det the,locus
R2464 T4003 T4001 pobj locus,of
R2465 T4004 T4003 compound Bmpr1a,locus
R2466 T4005 T4006 punct (,Mishina
R2467 T4006 T3992 meta Mishina,bred
R2468 T4007 T4006 nmod et,Mishina
R2469 T4008 T4006 nmod al.,Mishina
R2470 T4009 T4006 nummod 2002,Mishina
R2471 T4010 T4006 punct ),Mishina
R2472 T4011 T3992 punct ", ",bred
R2473 T4012 T4013 advmod usually,in
R2474 T4013 T3992 prep in,bred
R2475 T4014 T4015 det the,presence
R2476 T4015 T4013 pobj presence,in
R2477 T4016 T4015 prep of,presence
R2478 T4017 T4018 det the,allele
R2479 T4018 T4016 pobj allele,of
R2480 T4019 T4020 compound R26R,reporter
R2481 T4020 T4018 compound reporter,allele
R2482 T4021 T4022 aux to,facilitate
R2483 T4022 T3992 advcl facilitate,bred
R2484 T4023 T4024 amod simultaneous,visualization
R2485 T4024 T4022 dobj visualization,facilitate
R2486 T4025 T4024 prep of,visualization
R2487 T4026 T4027 npadvmod Cre,mediated
R2488 T4027 T4029 amod mediated,patterns
R2489 T4028 T4027 punct -,mediated
R2490 T4029 T4025 pobj patterns,of
R2491 T4030 T4029 compound recombination,patterns
R2492 T4031 T4032 punct (,see
R2493 T4032 T3992 parataxis see,bred
R2494 T4033 T4034 amod typical,cross
R2495 T4034 T4032 dobj cross,see
R2496 T4035 T4032 prep in,see
R2497 T4036 T4035 pobj Figure,in
R2498 T4037 T4036 nummod 3,Figure
R2499 T4038 T4032 punct ),see
R2500 T4039 T3992 punct .,bred
R2501 T4041 T4042 compound PCR,amplification
R2502 T4042 T4043 nsubj amplification,confirmed
R2503 T4044 T4045 mark that,deleted
R2504 T4045 T4043 ccomp deleted,confirmed
R2505 T4046 T4047 det a,exon
R2506 T4047 T4045 nsubjpass exon,deleted
R2507 T4048 T4047 amod key,exon
R2508 T4049 T4047 prep of,exon
R2509 T4050 T4051 det the,gene
R2510 T4051 T4049 pobj gene,of
R2511 T4052 T4051 compound Bmpr1a,gene
R2512 T4053 T4045 auxpass was,deleted
R2513 T4054 T4045 prep in,deleted
R2514 T4055 T4054 pobj mice,in
R2515 T4056 T4057 dep that,carried
R2516 T4057 T4055 relcl carried,mice
R2517 T4058 T4057 advmod also,carried
R2518 T4059 T4060 det the,transgene
R2519 T4060 T4057 dobj transgene,carried
R2520 T4061 T4062 compound Gdf5,Cre
R2521 T4062 T4060 compound Cre,transgene
R2522 T4063 T4062 punct -,Cre
R2523 T4064 T4065 punct (,data
R2524 T4065 T4045 meta data,deleted
R2525 T4066 T4065 amod unpublished,data
R2526 T4067 T4065 punct ),data
R2527 T4068 T4043 punct .,confirmed
R2528 T4070 T4071 amod Previous,studies
R2529 T4071 T4072 nsubj studies,shown
R2530 T4073 T4072 aux have,shown
R2531 T4074 T4075 mark that,mimics
R2532 T4075 T4072 ccomp mimics,shown
R2533 T4076 T4077 det the,allele
R2534 T4077 T4075 nsubj allele,mimics
R2535 T4078 T4077 amod recombined,allele
R2536 T4079 T4077 compound Bmpr1afloxP,allele
R2537 T4080 T4081 det a,allele
R2538 T4081 T4075 dobj allele,mimics
R2539 T4082 T4081 amod null,allele
R2540 T4083 T4081 prep of,allele
R2541 T4084 T4085 det the,locus
R2542 T4085 T4083 pobj locus,of
R2543 T4086 T4085 compound Bmpr1a,locus
R2544 T4087 T4088 advmod when,transmitted
R2545 T4088 T4075 advcl transmitted,mimics
R2546 T4089 T4088 prep through,transmitted
R2547 T4090 T4091 det the,germline
R2548 T4091 T4089 pobj germline,through
R2549 T4092 T4093 punct (,Mishina
R2550 T4093 T4072 meta Mishina,shown
R2551 T4094 T4093 nmod et,Mishina
R2552 T4095 T4093 nmod al.,Mishina
R2553 T4096 T4093 nummod 2002,Mishina
R2554 T4097 T4093 punct ),Mishina
R2555 T4098 T4072 punct .,shown
R2556 T4100 T4101 det The,mice
R2557 T4101 T4109 nsubj mice,were
R2558 T4102 T4103 nmod Gdf5,Cre
R2559 T4103 T4105 nmod Cre,Bmpr1afloxP
R2560 T4104 T4103 punct -,Cre
R2561 T4105 T4107 nmod Bmpr1afloxP,knockout
R2562 T4106 T4105 punct /,Bmpr1afloxP
R2563 T4107 T4101 compound knockout,mice
R2564 T4108 T4107 amod conditional,knockout
R2565 T4110 T4109 acomp viable,were
R2566 T4111 T4109 cc and,were
R2567 T4112 T4109 conj survived,were
R2568 T4113 T4112 prep to,survived
R2569 T4114 T4113 pobj adulthood,to
R2570 T4115 T4109 punct ", ",were
R2571 T4116 T4109 advcl showing,were
R2572 T4117 T4118 mark that,bypass
R2573 T4118 T4116 ccomp bypass,showing
R2574 T4119 T4120 det the,driver
R2575 T4120 T4118 nsubj driver,bypass
R2576 T4121 T4122 compound Gdf5,Cre
R2577 T4122 T4120 compound Cre,driver
R2578 T4123 T4122 punct -,Cre
R2579 T4124 T4118 aux can,bypass
R2580 T4125 T4126 det the,lethality
R2581 T4126 T4118 dobj lethality,bypass
R2582 T4127 T4126 amod early,lethality
R2583 T4128 T4126 amod embryonic,lethality
R2584 T4129 T4130 advmod previously,reported
R2585 T4130 T4126 acl reported,lethality
R2586 T4131 T4130 prep in,reported
R2587 T4132 T4131 pobj animals,in
R2588 T4133 T4132 prep with,animals
R2589 T4134 T4135 det a,mutation
R2590 T4135 T4133 pobj mutation,with
R2591 T4136 T4135 amod null,mutation
R2592 T4137 T4135 prep in,mutation
R2593 T4138 T4139 det the,locus
R2594 T4139 T4137 pobj locus,in
R2595 T4140 T4139 compound Bmpr1a,locus
R2596 T4141 T4142 punct (,Mishina
R2597 T4142 T4109 meta Mishina,were
R2598 T4143 T4142 nmod et,Mishina
R2599 T4144 T4142 nmod al.,Mishina
R2600 T4145 T4142 nummod 1995,Mishina
R2601 T4146 T4142 punct ),Mishina
R2602 T4147 T4109 punct .,were
R2603 T4149 T4150 det The,mice
R2604 T4150 T4157 nsubj mice,showed
R2605 T4151 T4150 amod viable,mice
R2606 T4152 T4153 compound Gdf5,Cre
R2607 T4153 T4155 compound Cre,Bmpr1afloxP
R2608 T4154 T4153 punct -,Cre
R2609 T4155 T4150 compound Bmpr1afloxP,mice
R2610 T4156 T4155 punct /,Bmpr1afloxP
R2611 T4158 T4159 amod several,phenotypes
R2612 T4159 T4157 dobj phenotypes,showed
R2613 T4160 T4157 punct .,showed
R2614 T4162 T4163 advmod First,had
R2615 T4164 T4163 punct ", ",had
R2616 T4165 T4166 det the,mice
R2617 T4166 T4163 nsubj mice,had
R2618 T4167 T4166 amod conditional,mice
R2619 T4168 T4166 compound knockout,mice
R2620 T4169 T4170 amod shorter,ears
R2621 T4170 T4163 dobj ears,had
R2622 T4171 T4172 dep that,lay
R2623 T4172 T4170 relcl lay,ears
R2624 T4173 T4172 advmod often,lay
R2625 T4174 T4172 advcl flatter,lay
R2626 T4175 T4174 prep against,flatter
R2627 T4176 T4177 poss their,heads
R2628 T4177 T4175 pobj heads,against
R2629 T4178 T4174 prep than,flatter
R2630 T4179 T4178 pobj controls,than
R2631 T4180 T4181 punct (,0.0001
R2632 T4181 T4163 parataxis 0.0001,had
R2633 T4182 T4183 nsubj controls,mm
R2634 T4183 T4181 dep mm,0.0001
R2635 T4184 T4185 quantmod 13.1,0.1
R2636 T4185 T4183 nummod 0.1,mm
R2637 T4186 T4185 punct ±,0.1
R2638 T4187 T4183 advmod long,mm
R2639 T4188 T4181 punct ", ",0.0001
R2640 T4189 T4190 nsubj n,38
R2641 T4190 T4181 ccomp 38,0.0001
R2642 T4191 T4190 punct =,38
R2643 T4192 T4181 punct ;,0.0001
R2644 T4193 T4194 nsubj mutants,mm
R2645 T4194 T4181 dep mm,0.0001
R2646 T4195 T4196 quantmod 11.8,0.2
R2647 T4196 T4194 nummod 0.2,mm
R2648 T4197 T4196 punct ±,0.2
R2649 T4198 T4181 punct ", ",0.0001
R2650 T4199 T4200 nsubj n,11
R2651 T4200 T4181 ccomp 11,0.0001
R2652 T4201 T4200 punct =,11
R2653 T4202 T4181 punct ;,0.0001
R2654 T4203 T4181 nsubj p,0.0001
R2655 T4204 T4181 punct <,0.0001
R2656 T4205 T4181 punct ),0.0001
R2657 T4206 T4163 punct .,had
R2658 T4208 T4209 compound BMP,signaling
R2659 T4209 T4210 nsubjpass signaling,known
R2660 T4211 T4210 auxpass is,known
R2661 T4212 T4213 aux to,required
R2662 T4213 T4210 xcomp required,known
R2663 T4214 T4213 auxpass be,required
R2664 T4215 T4213 prep for,required
R2665 T4216 T4215 pobj growth,for
R2666 T4217 T4216 prep of,growth
R2667 T4218 T4219 det the,ear
R2668 T4219 T4217 pobj ear,of
R2669 T4220 T4219 amod external,ear
R2670 T4221 T4219 prep of,ear
R2671 T4222 T4221 pobj mice,of
R2672 T4223 T4224 punct (,Kingsley
R2673 T4224 T4210 meta Kingsley,known
R2674 T4225 T4224 nmod et,Kingsley
R2675 T4226 T4224 nmod al.,Kingsley
R2676 T4227 T4224 nummod 1992,Kingsley
R2677 T4228 T4224 punct ),Kingsley
R2678 T4229 T4210 punct ", ",known
R2679 T4230 T4210 cc and,known
R2680 T4231 T4232 det this,phenotype
R2681 T4232 T4233 nsubj phenotype,reflects
R2682 T4233 T4210 conj reflects,known
R2683 T4234 T4233 advmod likely,reflects
R2684 T4235 T4233 dobj loss,reflects
R2685 T4236 T4235 prep of,loss
R2686 T4237 T4238 compound Bmpr1a,function
R2687 T4238 T4236 pobj function,of
R2688 T4239 T4233 prep in,reflects
R2689 T4240 T4241 det the,fraction
R2690 T4241 T4239 pobj fraction,in
R2691 T4242 T4241 prep of,fraction
R2692 T4243 T4244 compound ear,cells
R2693 T4244 T4242 pobj cells,of
R2694 T4245 T4246 dep that,express
R2695 T4246 T4241 relcl express,fraction
R2696 T4247 T4248 det the,transgene
R2697 T4248 T4246 dobj transgene,express
R2698 T4249 T4250 compound Gdf5,Cre
R2699 T4250 T4248 compound Cre,transgene
R2700 T4251 T4250 punct -,Cre
R2701 T4252 T4233 punct .,reflects
R2702 T4254 T4255 amod Most,mice
R2703 T4255 T4257 nsubj mice,showed
R2704 T4256 T4255 compound mutant,mice
R2705 T4258 T4257 advmod also,showed
R2706 T4259 T4260 amod soft,tissue
R2707 T4260 T4261 compound tissue,syndactyly
R2708 T4261 T4257 dobj syndactyly,showed
R2709 T4262 T4261 cc or,syndactyly
R2710 T4263 T4261 conj retention,syndactyly
R2711 T4264 T4263 prep of,retention
R2712 T4265 T4264 pobj webbing,of
R2713 T4266 T4265 prep between,webbing
R2714 T4267 T4268 det the,digits
R2715 T4268 T4266 pobj digits,between
R2716 T4269 T4268 amod first,digits
R2717 T4270 T4269 cc and,first
R2718 T4271 T4269 conj second,first
R2719 T4272 T4268 prep of,digits
R2720 T4273 T4274 poss their,feet
R2721 T4274 T4272 pobj feet,of
R2722 T4275 T4261 punct ", ",syndactyly
R2723 T4276 T4277 det a,phenotype
R2724 T4277 T4261 appos phenotype,syndactyly
R2725 T4278 T4279 dep that,was
R2726 T4279 T4277 relcl was,phenotype
R2727 T4280 T4281 advmod more,frequent
R2728 T4281 T4279 acomp frequent,was
R2729 T4282 T4281 cc and,frequent
R2730 T4283 T4284 advmod more,severe
R2731 T4284 T4281 conj severe,frequent
R2732 T4285 T4279 prep in,was
R2733 T4286 T4287 det the,forelimbs
R2734 T4287 T4285 pobj forelimbs,in
R2735 T4288 T4289 punct (,220
R2736 T4289 T4279 parataxis 220,was
R2737 T4290 T4289 quantmod 201,220
R2738 T4291 T4289 quantmod of,220
R2739 T4292 T4289 punct ", ",220
R2740 T4293 T4289 cc or,220
R2741 T4294 T4295 nummod 91,%
R2742 T4295 T4289 conj %,220
R2743 T4296 T4289 punct ", ",220
R2744 T4297 T4289 prep of,220
R2745 T4298 T4297 pobj forefeet,of
R2746 T4299 T4289 cc and,220
R2747 T4300 T4301 quantmod 109,220
R2748 T4301 T4289 conj 220,220
R2749 T4302 T4301 quantmod of,220
R2750 T4303 T4301 punct ", ",220
R2751 T4304 T4301 cc or,220
R2752 T4305 T4306 nummod 50,%
R2753 T4306 T4301 conj %,220
R2754 T4307 T4301 punct ", ",220
R2755 T4308 T4301 prep of,220
R2756 T4309 T4308 pobj hindfeet,of
R2757 T4310 T4289 punct ),220
R2758 T4311 T4257 punct .,showed
R2759 T4313 T4314 advmod Finally,showed
R2760 T4315 T4314 punct ", ",showed
R2761 T4316 T4317 compound mutant,animals
R2762 T4317 T4314 nsubj animals,showed
R2763 T4318 T4319 amod obvious,changes
R2764 T4319 T4314 dobj changes,showed
R2765 T4320 T4319 amod skeletal,changes
R2766 T4321 T4314 prep in,showed
R2767 T4322 T4323 amod whole,mount
R2768 T4323 T4325 nmod mount,preparations
R2769 T4324 T4323 punct -,mount
R2770 T4325 T4321 pobj preparations,in
R2771 T4326 T4325 amod skeletal,preparations
R2772 T4327 T4314 punct .,showed
R2773 T4329 T4330 prep At,seemed
R2774 T4331 T4332 det some,sites
R2775 T4332 T4329 pobj sites,At
R2776 T4333 T4332 prep in,sites
R2777 T4334 T4335 det the,ankles
R2778 T4335 T4333 pobj ankles,in
R2779 T4336 T4330 punct ", ",seemed
R2780 T4337 T4330 nsubj joints,seemed
R2781 T4338 T4339 aux to,be
R2782 T4339 T4330 xcomp be,seemed
R2783 T4340 T4339 acomp missing,be
R2784 T4341 T4339 advmod entirely,be
R2785 T4342 T4339 punct ", ",be
R2786 T4343 T4339 prep with,be
R2787 T4344 T4343 pobj fusion,with
R2788 T4345 T4344 prep of,fusion
R2789 T4346 T4345 pobj bones,of
R2790 T4347 T4348 dep that,be
R2791 T4348 T4346 relcl be,bones
R2792 T4349 T4348 aux would,be
R2793 T4350 T4348 advmod normally,be
R2794 T4351 T4348 acomp separate,be
R2795 T4352 T4330 punct .,seemed
R2796 T4354 T4355 prep For,fused
R2797 T4356 T4354 pobj example,For
R2798 T4357 T4355 punct ", ",fused
R2799 T4358 T4359 det the,tarsal
R2800 T4359 T4355 nsubjpass tarsal,fused
R2801 T4360 T4359 amod second,tarsal
R2802 T4361 T4359 amod distal,tarsal
R2803 T4362 T4355 auxpass was,fused
R2804 T4363 T4355 prep to,fused
R2805 T4364 T4365 det the,bone
R2806 T4365 T4363 pobj bone,to
R2807 T4366 T4365 amod central,bone
R2808 T4367 T4365 amod tarsal,bone
R2809 T4368 T4355 prep in,fused
R2810 T4369 T4370 det every,animal
R2811 T4370 T4368 pobj animal,in
R2812 T4371 T4372 amod conditional,knockout
R2813 T4372 T4370 compound knockout,animal
R2814 T4373 T4370 acl examined,animal
R2815 T4374 T4375 punct (,18
R2816 T4375 T4370 parataxis 18,animal
R2817 T4376 T4375 quantmod 18,18
R2818 T4377 T4375 quantmod of,18
R2819 T4378 T4375 punct ),18
R2820 T4379 T4355 punct ", ",fused
R2821 T4380 T4381 det a,phenotype
R2822 T4381 T4355 npadvmod phenotype,fused
R2823 T4382 T4383 neg not,observed
R2824 T4383 T4381 acl observed,phenotype
R2825 T4384 T4383 prep in,observed
R2826 T4385 T4384 pobj controls,in
R2827 T4386 T4387 punct (,18
R2828 T4387 T4383 parataxis 18,observed
R2829 T4388 T4387 quantmod zero,18
R2830 T4389 T4387 quantmod of,18
R2831 T4390 T4387 punct ),18
R2832 T4391 T4392 punct (,Figure
R2833 T4392 T4355 parataxis Figure,fused
R2834 T4393 T4392 nummod 3B,Figure
R2835 T4394 T4392 cc and,Figure
R2836 T4395 T4392 conj 3C,Figure
R2837 T4396 T4392 punct ),Figure
R2838 T4397 T4355 punct .,fused
R2839 T4399 T4400 prep At,formed
R2840 T4401 T4402 amod other,locations
R2841 T4402 T4399 pobj locations,At
R2842 T4403 T4400 punct ", ",formed
R2843 T4404 T4400 nsubj joints,formed
R2844 T4405 T4400 aux had,formed
R2845 T4406 T4400 advmod clearly,formed
R2846 T4407 T4400 cc but,formed
R2847 T4408 T4400 conj showed,formed
R2848 T4409 T4410 amod dramatic,loss
R2849 T4410 T4408 dobj loss,showed
R2850 T4411 T4410 prep of,loss
R2851 T4412 T4411 pobj staining,of
R2852 T4413 T4412 prep with,staining
R2853 T4414 T4415 det the,marker
R2854 T4415 T4413 pobj marker,with
R2855 T4416 T4415 compound cartilage,marker
R2856 T4417 T4415 compound matrix,marker
R2857 T4418 T4419 amod Alcian,blue
R2858 T4419 T4415 appos blue,marker
R2859 T4420 T4421 punct (,3B
R2860 T4421 T4408 parataxis 3B,showed
R2861 T4422 T4421 compound Figure,3B
R2862 T4423 T4424 punct –,3E
R2863 T4424 T4421 prep 3E,3B
R2864 T4425 T4421 punct ),3B
R2865 T4426 T4427 punct (,data
R2866 T4427 T4408 meta data,showed
R2867 T4428 T4427 amod unpublished,data
R2868 T4429 T4427 punct ),data
R2869 T4430 T4400 punct .,formed
R2870 T4432 T4433 amod Normal,staining
R2871 T4433 T4436 nsubjpass staining,seen
R2872 T4434 T4435 amod Alcian,blue
R2873 T4435 T4433 compound blue,staining
R2874 T4437 T4436 auxpass was,seen
R2875 T4438 T4436 prep in,seen
R2876 T4439 T4440 amod non-articular,regions
R2877 T4440 T4438 pobj regions,in
R2878 T4441 T4440 punct ", ",regions
R2879 T4442 T4443 amod such,as
R2880 T4443 T4440 prep as,regions
R2881 T4444 T4445 det the,plate
R2882 T4445 T4443 pobj plate,as
R2883 T4446 T4445 amod cartilaginous,plate
R2884 T4447 T4445 compound growth,plate
R2885 T4448 T4449 punct (,asterisk
R2886 T4449 T4436 parataxis asterisk,seen
R2887 T4450 T4451 nmod Figure,3D
R2888 T4451 T4449 dep 3D,asterisk
R2889 T4452 T4451 cc and,3D
R2890 T4453 T4451 conj 3E,3D
R2891 T4454 T4449 punct ", ",asterisk
R2892 T4455 T4449 punct ),asterisk
R2893 T4456 T4436 punct .,seen
R2894 T4458 T4459 det These,data
R2895 T4459 T4460 nsubj data,suggest
R2896 T4461 T4462 mark that,is
R2897 T4462 T4460 ccomp is,suggest
R2898 T4463 T4464 compound Bmpr1a,function
R2899 T4464 T4462 nsubj function,is
R2900 T4465 T4462 acomp required,is
R2901 T4466 T4462 prep for,is
R2902 T4467 T4468 det the,formation
R2903 T4468 T4466 pobj formation,for
R2904 T4469 T4468 prep of,formation
R2905 T4470 T4471 amod specific,joints
R2906 T4471 T4469 pobj joints,of
R2907 T4472 T4468 prep in,formation
R2908 T4473 T4474 det the,region
R2909 T4474 T4472 pobj region,in
R2910 T4475 T4474 compound ankle,region
R2911 T4476 T4466 cc and,for
R2912 T4477 T4466 conj for,for
R2913 T4478 T4479 preconj either,generation
R2914 T4479 T4477 pobj generation,for
R2915 T4480 T4479 cc or,generation
R2916 T4481 T4479 conj maintenance,generation
R2917 T4482 T4479 prep of,generation
R2918 T4483 T4484 amod articular,cartilage
R2919 T4484 T4482 pobj cartilage,of
R2920 T4485 T4479 prep in,generation
R2921 T4486 T4487 amod most,joints
R2922 T4487 T4485 pobj joints,in
R2923 T4488 T4487 amod other,joints
R2924 T4489 T4487 prep of,joints
R2925 T4490 T4491 det the,limb
R2926 T4491 T4489 pobj limb,of
R2927 T4492 T4460 punct .,suggest

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T3843 0-4 PR_EXT:000000281 denotes Gdf5
T3844 9-15 PR_EXT:000000035 denotes Bmpr1a
T3845 15-20 SO:0000359 denotes floxP
T3846 21-28 NCBITaxon:33208 denotes Animals
T3847 40-49 UBERON:0000113 denotes Adulthood
T3848 55-58 UBERON:0001690 denotes Ear
T3849 73-78 UBERON:0004905 denotes Joint
T3850 104-108 PR_EXT:000000281 denotes Gdf5
T3851 140-143 PR_EXT:000000034 denotes BMP
T3852 140-153 GO:0030509 denotes BMP signaling
T3853 168-173 UBERON:0004905 denotes joint
T3854 187-191 PR_EXT:000000281 denotes Gdf5
T3855 196-206 SO_EXT:transgenic_entity denotes transgenic
T3856 207-211 NCBITaxon:10088 denotes mice
T3857 217-221 GO_EXT:breeding denotes bred
T3858 225-232 NCBITaxon:33208 denotes animals
T3859 256-262 SO:0000359 denotes floxed
T3860 263-269 SO_EXT:0001023 denotes allele
T3861 277-283 PR_EXT:000000035 denotes Bmpr1a
T3862 358-364 SO_EXT:0001023 denotes allele
T3863 422-435 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T3864 517-521 SO_EXT:0000147 denotes exon
T3865 529-535 PR_EXT:000000035 denotes Bmpr1a
T3866 536-540 SO_EXT:0000704 denotes gene
T3867 545-552 SO_EXT:sequence_deletion_process denotes deleted
T3868 556-560 NCBITaxon:10088 denotes mice
T3869 583-587 PR_EXT:000000281 denotes Gdf5
T3870 592-601 SO_EXT:0000902 denotes transgene
T3871 659-669 GO_SO_EXT:sequence_rearrangement_process denotes recombined
T3872 670-676 PR_EXT:000000035 denotes Bmpr1a
T3873 676-681 SO:0000359 denotes floxP
T3874 682-688 SO_EXT:0001023 denotes allele
T3875 698-702 SO_EXT:sequence_nullness denotes null
T3876 703-709 SO_EXT:0001023 denotes allele
T3877 717-723 PR_EXT:000000035 denotes Bmpr1a
T3878 795-799 PR_EXT:000000281 denotes Gdf5
T3879 804-810 PR_EXT:000000035 denotes Bmpr1a
T3880 810-815 SO:0000359 denotes floxP
T3881 837-841 NCBITaxon:10088 denotes mice
T3882 870-879 UBERON:0000113 denotes adulthood
T3883 898-902 PR_EXT:000000281 denotes Gdf5
T3884 929-944 UBERON:0019248 denotes early embryonic
T3885 945-954 GO_EXT:fatality_or_lethality denotes lethality
T3886 978-985 NCBITaxon:33208 denotes animals
T3887 993-997 SO_EXT:sequence_nullness denotes null
T3888 998-1006 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T3889 1014-1020 PR_EXT:000000035 denotes Bmpr1a
T3890 1887-1891 PR_EXT:000000281 denotes Gdf5
T3891 1896-1902 PR_EXT:000000035 denotes Bmpr1a
T3892 1902-1907 SO:0000359 denotes floxP
T3893 1908-1912 NCBITaxon:10088 denotes mice
T3894 1972-1976 NCBITaxon:10088 denotes mice
T3895 1989-1993 UBERON:0001690 denotes ears
T3896 2031-2036 UBERON:0000033 denotes heads
T3897 2089-2096 SO_EXT:sequence_altered_entity denotes mutants
T3898 2133-2136 PR_EXT:000000034 denotes BMP
T3899 2133-2146 GO:0030509 denotes BMP signaling
T3900 2175-2181 GO_EXT:biological_growth_entity_or_process denotes growth
T3901 2189-2201 UBERON:0001691 denotes external ear
T3902 2205-2209 NCBITaxon:10088 denotes mice
T3903 2277-2283 PR_EXT:000000035 denotes Bmpr1a
T3904 2312-2315 UBERON:0001690 denotes ear
T3905 2316-2321 CL_GO_EXT:cell denotes cells
T3906 2327-2334 GO:0010467 denotes express
T3907 2339-2343 PR_EXT:000000281 denotes Gdf5
T3908 2348-2357 SO_EXT:0000902 denotes transgene
T3909 2364-2370 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3910 2371-2375 NCBITaxon:10088 denotes mice
T3911 2393-2399 UBERON:0000479 denotes tissue
T3916 2447-2452,2427-2442,2464-2473,2480-2484,2480-2484 UBERON:0003631 denotes first webbing between digits of feet feet
T3918 2457-2473,2480-2484 UBERON:0003632 denotes second digits of feet
T3919 2544-2553 UBERON:0002102 denotes forelimbs
T3920 2578-2586 UBERON:0002398 denotes forefeet
T3921 2614-2622 UBERON:0002387 denotes hindfeet
T3922 2634-2640 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3923 2641-2648 NCBITaxon:33208 denotes animals
T3924 2664-2672 UBERON:0004288 denotes skeletal
T3925 2696-2704 UBERON:0004288 denotes skeletal
T3926 2740-2746 UBERON:0004454 denotes ankles
T3927 2748-2754 UBERON:0004905 denotes joints
T3928 2801-2806 UBERON:0001474 denotes bones
T3929 2857-2877 UBERON:0001453 denotes second distal tarsal
T3930 2895-2914 UBERON:4200011 denotes central tarsal bone
T3931 2945-2951 NCBITaxon:33208 denotes animal
T3932 3063-3069 UBERON:0004905 denotes joints
T3933 3135-3144 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T3934 3145-3151 GO:0031012 denotes matrix
T3935 3152-3158 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T3936 3250-3259 UBERON:0004905 denotes articular
T3937 3281-3307 UBERON:0004129 denotes cartilaginous growth plate
T3938 3295-3301 GO_EXT:biological_growth_entity_or_process denotes growth
T3939 3362-3368 PR_EXT:000000035 denotes Bmpr1a
T3940 3420-3426 UBERON:0004905 denotes joints
T3941 3434-3446 UBERON:0004454 denotes ankle region
T3944 3462-3472,3488-3490,3501-3510 GO:0051216 denotes generation of cartilage
T3945 3491-3510 UBERON:0010996 denotes articular cartilage
T3947 3525-3534,3539-3543 UBERON:0003657 denotes joints of limb

craft-ca-core-dev

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue
T3755 0-4 PR:000000281 denotes Gdf5
T3756 9-15 PR:000000035 denotes Bmpr1a
T3757 15-20 SO:0000359 denotes floxP
T3758 21-28 NCBITaxon:33208 denotes Animals
T3759 40-49 UBERON:0000113 denotes Adulthood
T3760 55-58 UBERON:0001690 denotes Ear
T3761 73-78 UBERON:0004905 denotes Joint
T3762 104-108 PR:000000281 denotes Gdf5
T3763 140-143 PR:000000034 denotes BMP
T3764 140-153 GO:0030509 denotes BMP signaling
T3765 168-173 UBERON:0004905 denotes joint
T3766 187-191 PR:000000281 denotes Gdf5
T3767 207-211 NCBITaxon:10088 denotes mice
T3768 225-232 NCBITaxon:33208 denotes animals
T3769 256-262 SO:0000359 denotes floxed
T3770 263-269 SO:0001023 denotes allele
T3771 277-283 PR:000000035 denotes Bmpr1a
T3772 358-364 SO:0001023 denotes allele
T3773 517-521 SO:0000147 denotes exon
T3774 529-535 PR:000000035 denotes Bmpr1a
T3775 536-540 SO:0000704 denotes gene
T3776 556-560 NCBITaxon:10088 denotes mice
T3777 583-587 PR:000000281 denotes Gdf5
T3778 592-601 SO:0000902 denotes transgene
T3779 670-676 PR:000000035 denotes Bmpr1a
T3780 676-681 SO:0000359 denotes floxP
T3781 682-688 SO:0001023 denotes allele
T3782 703-709 SO:0001023 denotes allele
T3783 717-723 PR:000000035 denotes Bmpr1a
T3784 795-799 PR:000000281 denotes Gdf5
T3785 804-810 PR:000000035 denotes Bmpr1a
T3786 810-815 SO:0000359 denotes floxP
T3787 837-841 NCBITaxon:10088 denotes mice
T3788 870-879 UBERON:0000113 denotes adulthood
T3789 898-902 PR:000000281 denotes Gdf5
T3790 929-944 UBERON:0019248 denotes early embryonic
T3791 978-985 NCBITaxon:33208 denotes animals
T3792 1014-1020 PR:000000035 denotes Bmpr1a
T3793 1887-1891 PR:000000281 denotes Gdf5
T3794 1896-1902 PR:000000035 denotes Bmpr1a
T3795 1902-1907 SO:0000359 denotes floxP
T3796 1908-1912 NCBITaxon:10088 denotes mice
T3797 1972-1976 NCBITaxon:10088 denotes mice
T3798 1989-1993 UBERON:0001690 denotes ears
T3799 2031-2036 UBERON:0000033 denotes heads
T3800 2133-2136 PR:000000034 denotes BMP
T3801 2133-2146 GO:0030509 denotes BMP signaling
T3802 2189-2201 UBERON:0001691 denotes external ear
T3803 2205-2209 NCBITaxon:10088 denotes mice
T3804 2277-2283 PR:000000035 denotes Bmpr1a
T3805 2312-2315 UBERON:0001690 denotes ear
T3806 2327-2334 GO:0010467 denotes express
T3807 2339-2343 PR:000000281 denotes Gdf5
T3808 2348-2357 SO:0000902 denotes transgene
T3809 2371-2375 NCBITaxon:10088 denotes mice
T3810 2393-2399 UBERON:0000479 denotes tissue
T3815 2447-2452,2427-2442,2464-2473,2480-2484,2480-2484 UBERON:0003631 denotes first webbing between digits of feet feet
T3817 2457-2473,2480-2484 UBERON:0003632 denotes second digits of feet
T3818 2544-2553 UBERON:0002102 denotes forelimbs
T3819 2578-2586 UBERON:0002398 denotes forefeet
T3820 2614-2622 UBERON:0002387 denotes hindfeet
T3821 2641-2648 NCBITaxon:33208 denotes animals
T3822 2664-2672 UBERON:0004288 denotes skeletal
T3823 2696-2704 UBERON:0004288 denotes skeletal
T3824 2740-2746 UBERON:0004454 denotes ankles
T3825 2748-2754 UBERON:0004905 denotes joints
T3826 2801-2806 UBERON:0001474 denotes bones
T3827 2857-2877 UBERON:0001453 denotes second distal tarsal
T3828 2895-2914 UBERON:4200011 denotes central tarsal bone
T3829 2945-2951 NCBITaxon:33208 denotes animal
T3830 3063-3069 UBERON:0004905 denotes joints
T3831 3145-3151 GO:0031012 denotes matrix
T3832 3250-3259 UBERON:0004905 denotes articular
T3833 3281-3307 UBERON:0004129 denotes cartilaginous growth plate
T3834 3362-3368 PR:000000035 denotes Bmpr1a
T3835 3420-3426 UBERON:0004905 denotes joints
T3836 3434-3446 UBERON:0004454 denotes ankle region
T3839 3462-3472,3488-3490,3501-3510 GO:0051216 denotes generation of cartilage
T3840 3491-3510 UBERON:0010996 denotes articular cartilage
T3842 3525-3534,3539-3543 UBERON:0003657 denotes joints of limb

2_test

Id Subject Object Predicate Lexical cue
15492776-11857780-84887307 306-310 11857780 denotes 2002
15492776-11857780-84887308 784-788 11857780 denotes 2002
15492776-8543149-84887309 1043-1047 8543149 denotes 1995
15492776-1339316-84887310 2227-2231 1339316 denotes 1992
T80010 306-310 11857780 denotes 2002
T88995 784-788 11857780 denotes 2002
T59203 1043-1047 8543149 denotes 1995
T7576 2227-2231 1339316 denotes 1992