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PMC:523229 / 128-2191 JSONTXT

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Id Subject Object Predicate Lexical cue
T250 0-147 sentence denotes Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis.
T251 0-9 JJ denotes Articular
T252 10-19 NN denotes cartilage
T253 20-25 VBZ denotes plays
T254 26-28 DT denotes an
T255 39-43 NN denotes role
T256 29-38 JJ denotes essential
T257 44-46 IN denotes in
T258 47-53 NN denotes health
T259 54-57 CC denotes and
T260 58-66 NN denotes mobility
T261 66-68 , denotes ,
T262 68-71 CC denotes but
T263 72-74 VBZ denotes is
T264 86-93 VBN denotes damaged
T265 75-85 RB denotes frequently
T266 94-96 CC denotes or
T267 97-101 VBN denotes lost
T268 102-104 IN denotes in
T269 105-113 NNS denotes millions
T270 114-116 IN denotes of
T271 117-123 NNS denotes people
T272 124-128 WDT denotes that
T273 129-136 VBP denotes develop
T274 137-146 NN denotes arthritis
T275 146-147 . denotes .
T276 147-404 sentence denotes The molecular mechanisms that create and maintain this thin layer of cartilage that covers the surface of bones in joint regions are poorly understood, in part because tools to manipulate gene expression specifically in this tissue have not been available.
T277 148-151 DT denotes The
T278 162-172 NNS denotes mechanisms
T279 152-161 JJ denotes molecular
T280 288-298 VBN denotes understood
T281 173-177 WDT denotes that
T282 178-184 VBP denotes create
T283 185-188 CC denotes and
T284 189-197 VBP denotes maintain
T285 198-202 DT denotes this
T286 208-213 NN denotes layer
T287 203-207 JJ denotes thin
T288 214-216 IN denotes of
T289 217-226 NN denotes cartilage
T290 227-231 WDT denotes that
T291 232-238 VBZ denotes covers
T292 239-242 DT denotes the
T293 243-250 NN denotes surface
T294 251-253 IN denotes of
T295 254-259 NNS denotes bones
T296 260-262 IN denotes in
T297 263-268 NN denotes joint
T298 269-276 NNS denotes regions
T299 277-280 VBP denotes are
T300 281-287 RB denotes poorly
T301 298-300 , denotes ,
T302 300-302 IN denotes in
T303 389-393 VBN denotes been
T304 303-307 JJ denotes part
T305 308-315 IN denotes because
T306 316-321 NNS denotes tools
T307 322-324 TO denotes to
T308 325-335 VB denotes manipulate
T309 336-340 NN denotes gene
T310 341-351 NN denotes expression
T311 352-364 RB denotes specifically
T312 365-367 IN denotes in
T313 368-372 DT denotes this
T314 373-379 NN denotes tissue
T315 380-384 VBP denotes have
T316 385-388 RB denotes not
T317 394-403 JJ denotes available
T318 403-404 . denotes .
T319 404-633 sentence denotes Here we use regulatory information from the mouse Gdf5 gene (a bone morphogenetic protein [BMP] family member) to develop new mouse lines that can be used to either activate or inactivate genes specifically in developing joints.
T320 405-409 RB denotes Here
T321 413-416 VBP denotes use
T322 410-412 PRP denotes we
T323 417-427 JJ denotes regulatory
T324 428-439 NN denotes information
T325 440-444 IN denotes from
T326 445-448 DT denotes the
T327 460-464 NN denotes gene
T328 449-454 NN denotes mouse
T329 455-459 NN denotes Gdf5
T330 465-466 -LRB- denotes (
T331 508-514 NN denotes member
T332 466-467 DT denotes a
T333 468-472 NN denotes bone
T334 487-494 NN denotes protein
T335 473-486 JJ denotes morphogenetic
T336 495-496 -LRB- denotes [
T337 496-499 NN denotes BMP
T338 499-500 -RRB- denotes ]
T339 501-507 NN denotes family
T340 514-515 -RRB- denotes )
T341 516-518 TO denotes to
T342 519-526 VB denotes develop
T343 527-530 JJ denotes new
T344 537-542 NNS denotes lines
T345 531-536 NN denotes mouse
T346 543-547 WDT denotes that
T347 555-559 VBN denotes used
T348 548-551 MD denotes can
T349 552-554 VB denotes be
T350 560-562 TO denotes to
T351 570-578 VB denotes activate
T352 563-569 CC denotes either
T353 579-581 CC denotes or
T354 582-592 VB denotes inactivate
T355 593-598 NNS denotes genes
T356 599-611 RB denotes specifically
T357 612-614 IN denotes in
T358 615-625 VBG denotes developing
T359 626-632 NNS denotes joints
T360 632-633 . denotes .
T361 633-886 sentence denotes Expression of Cre recombinase from Gdf5 bacterial artificial chromosome clones leads to specific activation or inactivation of floxed target genes in developing joints, including early joint interzones, adult articular cartilage, and the joint capsule.
T362 634-644 NN denotes Expression
T363 713-718 VBZ denotes leads
T364 645-647 IN denotes of
T365 648-651 NN denotes Cre
T366 652-663 NN denotes recombinase
T367 664-668 IN denotes from
T368 669-673 NN denotes Gdf5
T369 695-705 NN denotes chromosome
T370 674-683 JJ denotes bacterial
T371 684-694 JJ denotes artificial
T372 706-712 NNS denotes clones
T373 719-721 IN denotes to
T374 722-730 JJ denotes specific
T375 731-741 NN denotes activation
T376 742-744 CC denotes or
T377 745-757 NN denotes inactivation
T378 758-760 IN denotes of
T379 761-767 VBN denotes floxed
T380 775-780 NNS denotes genes
T381 768-774 NN denotes target
T382 781-783 IN denotes in
T383 784-794 VBG denotes developing
T384 795-801 NNS denotes joints
T385 801-803 , denotes ,
T386 803-812 VBG denotes including
T387 813-818 JJ denotes early
T388 825-835 NNS denotes interzones
T389 819-824 NN denotes joint
T390 835-837 , denotes ,
T391 837-842 NN denotes adult
T392 853-862 NN denotes cartilage
T393 843-852 JJ denotes articular
T394 862-864 , denotes ,
T395 864-867 CC denotes and
T396 868-871 DT denotes the
T397 878-885 NN denotes capsule
T398 872-877 NN denotes joint
T399 885-886 . denotes .
T400 886-976 sentence denotes We have used this system to test the role of BMP receptor signaling in joint development.
T401 887-889 PRP denotes We
T402 895-899 VBN denotes used
T403 890-894 VBP denotes have
T404 900-904 DT denotes this
T405 905-911 NN denotes system
T406 912-914 TO denotes to
T407 915-919 VB denotes test
T408 920-923 DT denotes the
T409 924-928 NN denotes role
T410 929-931 IN denotes of
T411 932-935 NN denotes BMP
T412 945-954 NN denotes signaling
T413 936-944 NN denotes receptor
T414 955-957 IN denotes in
T415 958-963 NN denotes joint
T416 964-975 NN denotes development
T417 975-976 . denotes .
T418 976-1074 sentence denotes Mice with null mutations in Bmpr1a are known to die early in embryogenesis with multiple defects.
T419 977-981 NNS denotes Mice
T420 1016-1021 VBN denotes known
T421 982-986 IN denotes with
T422 987-991 JJ denotes null
T423 992-1001 NNS denotes mutations
T424 1002-1004 IN denotes in
T425 1005-1011 NN denotes Bmpr1a
T426 1012-1015 VBP denotes are
T427 1022-1024 TO denotes to
T428 1025-1028 VB denotes die
T429 1029-1034 RB denotes early
T430 1035-1037 IN denotes in
T431 1038-1051 NN denotes embryogenesis
T432 1052-1056 IN denotes with
T433 1057-1065 JJ denotes multiple
T434 1066-1073 NNS denotes defects
T435 1073-1074 . denotes .
T436 1074-1275 sentence denotes However, combining a floxed Bmpr1a allele with the Gdf5-Cre driver bypasses this embryonic lethality, and leads to birth and postnatal development of mice missing the Bmpr1a gene in articular regions.
T437 1075-1082 RB denotes However
T438 1142-1150 VBZ denotes bypasses
T439 1082-1084 , denotes ,
T440 1084-1093 VBG denotes combining
T441 1094-1095 DT denotes a
T442 1110-1116 NN denotes allele
T443 1096-1102 VBN denotes floxed
T444 1103-1109 NN denotes Bmpr1a
T445 1117-1121 IN denotes with
T446 1122-1125 DT denotes the
T447 1135-1141 NN denotes driver
T448 1126-1130 NN denotes Gdf5
T449 1131-1134 NN denotes Cre
T450 1130-1131 HYPH denotes -
T451 1151-1155 DT denotes this
T452 1166-1175 NN denotes lethality
T453 1156-1165 JJ denotes embryonic
T454 1175-1177 , denotes ,
T455 1177-1180 CC denotes and
T456 1181-1186 VBZ denotes leads
T457 1187-1189 IN denotes to
T458 1190-1195 NN denotes birth
T459 1196-1199 CC denotes and
T460 1200-1209 JJ denotes postnatal
T461 1210-1221 NN denotes development
T462 1222-1224 IN denotes of
T463 1225-1229 NNS denotes mice
T464 1230-1237 VBG denotes missing
T465 1238-1241 DT denotes the
T466 1249-1253 NN denotes gene
T467 1242-1248 NN denotes Bmpr1a
T468 1254-1256 IN denotes in
T469 1257-1266 JJ denotes articular
T470 1267-1274 NNS denotes regions
T471 1274-1275 . denotes .
T472 1275-1357 sentence denotes Most joints in the body form normally in the absence of Bmpr1a receptor function.
T473 1276-1280 JJS denotes Most
T474 1281-1287 NNS denotes joints
T475 1300-1304 VBP denotes form
T476 1288-1290 IN denotes in
T477 1291-1294 DT denotes the
T478 1295-1299 NN denotes body
T479 1305-1313 RB denotes normally
T480 1314-1316 IN denotes in
T481 1317-1320 DT denotes the
T482 1321-1328 NN denotes absence
T483 1329-1331 IN denotes of
T484 1332-1338 NN denotes Bmpr1a
T485 1339-1347 NN denotes receptor
T486 1348-1356 NN denotes function
T487 1356-1357 . denotes .
T488 1357-1510 sentence denotes However, articular cartilage within the joints gradually wears away in receptor-deficient mice after birth in a process resembling human osteoarthritis.
T489 1358-1365 RB denotes However
T490 1415-1420 VBZ denotes wears
T491 1365-1367 , denotes ,
T492 1367-1376 JJ denotes articular
T493 1377-1386 NN denotes cartilage
T494 1387-1393 IN denotes within
T495 1394-1397 DT denotes the
T496 1398-1404 NNS denotes joints
T497 1405-1414 RB denotes gradually
T498 1421-1425 RP denotes away
T499 1426-1428 IN denotes in
T500 1429-1437 NN denotes receptor
T501 1448-1452 NNS denotes mice
T502 1437-1438 HYPH denotes -
T503 1438-1447 JJ denotes deficient
T504 1453-1458 IN denotes after
T505 1459-1464 NN denotes birth
T506 1465-1467 IN denotes in
T507 1468-1469 DT denotes a
T508 1470-1477 NN denotes process
T509 1478-1488 VBG denotes resembling
T510 1489-1494 JJ denotes human
T511 1495-1509 NN denotes osteoarthritis
T512 1509-1510 . denotes .
T513 1510-1614 sentence denotes Gdf5-Cre mice provide a general system that can be used to test the role of genes in articular regions.
T514 1511-1515 NN denotes Gdf5
T515 1516-1519 NN denotes Cre
T516 1515-1516 HYPH denotes -
T517 1520-1524 NNS denotes mice
T518 1525-1532 VBP denotes provide
T519 1533-1534 DT denotes a
T520 1543-1549 NN denotes system
T521 1535-1542 JJ denotes general
T522 1550-1554 WDT denotes that
T523 1562-1566 VBN denotes used
T524 1555-1558 MD denotes can
T525 1559-1561 VB denotes be
T526 1567-1569 TO denotes to
T527 1570-1574 VB denotes test
T528 1575-1578 DT denotes the
T529 1579-1583 NN denotes role
T530 1584-1586 IN denotes of
T531 1587-1592 NNS denotes genes
T532 1593-1595 IN denotes in
T533 1596-1605 JJ denotes articular
T534 1606-1613 NNS denotes regions
T535 1613-1614 . denotes .
T536 1614-1783 sentence denotes BMP receptor signaling is required not only for early development and creation of multiple tissues, but also for ongoing maintenance of articular cartilage after birth.
T537 1615-1618 NN denotes BMP
T538 1619-1627 NN denotes receptor
T539 1628-1637 NN denotes signaling
T540 1641-1649 VBN denotes required
T541 1638-1640 VBZ denotes is
T542 1650-1653 RB denotes not
T543 1659-1662 IN denotes for
T544 1654-1658 RB denotes only
T545 1663-1668 JJ denotes early
T546 1669-1680 NN denotes development
T547 1681-1684 CC denotes and
T548 1685-1693 NN denotes creation
T549 1694-1696 IN denotes of
T550 1697-1705 JJ denotes multiple
T551 1706-1713 NNS denotes tissues
T552 1713-1715 , denotes ,
T553 1715-1718 CC denotes but
T554 1719-1723 RB denotes also
T555 1724-1727 IN denotes for
T556 1728-1735 JJ denotes ongoing
T557 1736-1747 NN denotes maintenance
T558 1748-1750 IN denotes of
T559 1751-1760 JJ denotes articular
T560 1761-1770 NN denotes cartilage
T561 1771-1776 IN denotes after
T562 1777-1782 NN denotes birth
T563 1782-1783 . denotes .
T564 1783-2063 sentence denotes Genetic variation in the strength of BMP receptor signaling may be an important risk factor in human osteoarthritis, and treatments that mimic or augment BMP receptor signaling should be investigated as a possible therapeutic strategy for maintaining the health of joint linings.
T565 1784-1791 JJ denotes Genetic
T566 1792-1801 NN denotes variation
T567 1848-1850 VB denotes be
T568 1802-1804 IN denotes in
T569 1805-1808 DT denotes the
T570 1809-1817 NN denotes strength
T571 1818-1820 IN denotes of
T572 1821-1824 NN denotes BMP
T573 1825-1833 NN denotes receptor
T574 1834-1843 NN denotes signaling
T575 1844-1847 MD denotes may
T576 1851-1853 DT denotes an
T577 1869-1875 NN denotes factor
T578 1854-1863 JJ denotes important
T579 1864-1868 NN denotes risk
T580 1876-1878 IN denotes in
T581 1879-1884 JJ denotes human
T582 1885-1899 NN denotes osteoarthritis
T583 1899-1901 , denotes ,
T584 1901-1904 CC denotes and
T585 1905-1915 NNS denotes treatments
T586 1971-1983 VBN denotes investigated
T587 1916-1920 WDT denotes that
T588 1921-1926 VBP denotes mimic
T589 1927-1929 CC denotes or
T590 1930-1937 VBP denotes augment
T591 1938-1941 NN denotes BMP
T592 1942-1950 NN denotes receptor
T593 1951-1960 NN denotes signaling
T594 1961-1967 MD denotes should
T595 1968-1970 VB denotes be
T596 1984-1986 IN denotes as
T597 1987-1988 DT denotes a
T598 2010-2018 NN denotes strategy
T599 1989-1997 JJ denotes possible
T600 1998-2009 JJ denotes therapeutic
T601 2019-2022 IN denotes for
T602 2023-2034 VBG denotes maintaining
T603 2035-2038 DT denotes the
T604 2039-2045 NN denotes health
T605 2046-2048 IN denotes of
T606 2049-2054 NN denotes joint
T607 2055-2062 NNS denotes linings
T608 2062-2063 . denotes .
R19 T251 T252 amod Articular,cartilage
R20 T252 T253 nsubj cartilage,plays
R21 T254 T255 det an,role
R84 T320 T321 advmod Here,use
R85 T322 T321 nsubj we,use
R86 T323 T324 amod regulatory,information
R145 T384 T382 pobj joints,in
R146 T385 T384 punct ", ",joints
R147 T386 T384 prep including,joints
R148 T387 T388 amod early,interzones
R149 T388 T386 pobj interzones,including
R150 T389 T388 compound joint,interzones
R151 T390 T388 punct ", ",interzones
R152 T391 T392 nmod adult,cartilage
R153 T392 T388 conj cartilage,interzones
R154 T393 T392 amod articular,cartilage
R190 T433 T434 amod multiple,defects
R191 T434 T432 pobj defects,with
R192 T435 T420 punct .,known
R193 T437 T438 advmod However,bypasses
R194 T439 T438 punct ", ",bypasses
R195 T440 T438 csubj combining,bypasses
R213 T458 T457 pobj birth,to
R214 T459 T458 cc and,birth
R223 T468 T464 prep in,missing
R224 T469 T470 amod articular,regions
R225 T470 T468 pobj regions,in
R226 T471 T438 punct .,bypasses
R227 T473 T474 amod Most,joints
R228 T474 T475 nsubj joints,form
R229 T476 T474 prep in,joints
R230 T477 T478 det the,body
R293 T546 T543 pobj development,for
R294 T547 T546 cc and,development
R295 T548 T546 conj creation,development
R296 T549 T546 prep of,development
R297 T550 T551 amod multiple,tissues
R298 T551 T549 pobj tissues,of
R299 T552 T543 punct ", ",for
R300 T553 T543 cc but,for
R301 T554 T553 advmod also,but
R302 T555 T543 conj for,for
R303 T556 T557 amod ongoing,maintenance
R304 T557 T555 pobj maintenance,for
R305 T558 T557 prep of,maintenance
R306 T559 T560 amod articular,cartilage
R307 T560 T558 pobj cartilage,of
R308 T561 T557 prep after,maintenance
R309 T562 T561 pobj birth,after
R22 T255 T253 dobj role,plays
R23 T256 T255 amod essential,role
R24 T257 T253 prep in,plays
R25 T258 T257 pobj health,in
R26 T259 T258 cc and,health
R27 T260 T258 conj mobility,health
R28 T261 T253 punct ", ",plays
R29 T262 T253 cc but,plays
R30 T263 T264 auxpass is,damaged
R31 T264 T253 conj damaged,plays
R32 T265 T264 advmod frequently,damaged
R33 T266 T264 cc or,damaged
R34 T267 T264 conj lost,damaged
R35 T268 T267 prep in,lost
R36 T269 T268 pobj millions,in
R37 T270 T269 prep of,millions
R38 T271 T270 pobj people,of
R39 T272 T273 dep that,develop
R40 T273 T271 relcl develop,people
R41 T274 T273 dobj arthritis,develop
R42 T275 T253 punct .,plays
R43 T277 T278 det The,mechanisms
R44 T278 T280 nsubjpass mechanisms,understood
R45 T279 T278 amod molecular,mechanisms
R46 T281 T282 dep that,create
R47 T282 T278 relcl create,mechanisms
R48 T283 T282 cc and,create
R49 T284 T282 conj maintain,create
R50 T285 T286 det this,layer
R51 T286 T284 dobj layer,maintain
R52 T287 T286 amod thin,layer
R53 T288 T286 prep of,layer
R54 T289 T288 pobj cartilage,of
R55 T290 T291 dep that,covers
R56 T291 T286 relcl covers,layer
R57 T292 T293 det the,surface
R58 T293 T291 dobj surface,covers
R59 T294 T293 prep of,surface
R60 T295 T294 pobj bones,of
R61 T296 T291 prep in,covers
R62 T297 T298 compound joint,regions
R63 T298 T296 pobj regions,in
R64 T299 T280 auxpass are,understood
R65 T300 T280 advmod poorly,understood
R66 T301 T280 punct ", ",understood
R67 T302 T303 prep in,been
R68 T303 T280 advcl been,understood
R69 T304 T302 amod part,in
R70 T305 T303 mark because,been
R71 T306 T303 nsubj tools,been
R72 T307 T308 aux to,manipulate
R73 T308 T306 advcl manipulate,tools
R74 T309 T310 compound gene,expression
R75 T310 T308 dobj expression,manipulate
R76 T311 T312 advmod specifically,in
R77 T312 T308 prep in,manipulate
R78 T313 T314 det this,tissue
R79 T314 T312 pobj tissue,in
R80 T315 T303 aux have,been
R81 T316 T303 neg not,been
R82 T317 T303 acomp available,been
R83 T318 T280 punct .,understood
R87 T324 T321 dobj information,use
R88 T325 T324 prep from,information
R89 T326 T327 det the,gene
R90 T327 T325 pobj gene,from
R91 T328 T327 compound mouse,gene
R92 T329 T327 compound Gdf5,gene
R93 T330 T331 punct (,member
R95 T332 T331 det a,member
R96 T333 T334 nmod bone,protein
R97 T334 T331 nmod protein,member
R98 T335 T334 amod morphogenetic,protein
R99 T336 T337 punct [,BMP
R100 T337 T334 appos BMP,protein
R101 T338 T337 punct ],BMP
R102 T339 T331 compound family,member
R103 T340 T331 punct ),member
R104 T341 T342 aux to,develop
R105 T342 T321 advcl develop,use
R106 T343 T344 amod new,lines
R107 T344 T342 dobj lines,develop
R108 T345 T344 compound mouse,lines
R109 T346 T347 dep that,used
R110 T347 T344 relcl used,lines
R111 T348 T347 aux can,used
R112 T349 T347 auxpass be,used
R113 T350 T351 aux to,activate
R114 T351 T347 advcl activate,used
R115 T352 T351 preconj either,activate
R116 T353 T351 cc or,activate
R117 T354 T351 conj inactivate,activate
R118 T355 T354 dobj genes,inactivate
R119 T356 T354 advmod specifically,inactivate
R120 T357 T354 prep in,inactivate
R121 T358 T359 amod developing,joints
R122 T359 T357 pobj joints,in
R123 T360 T321 punct .,use
R124 T362 T363 nsubj Expression,leads
R125 T364 T362 prep of,Expression
R126 T365 T366 compound Cre,recombinase
R127 T366 T364 pobj recombinase,of
R128 T367 T366 prep from,recombinase
R129 T368 T369 nmod Gdf5,chromosome
R130 T369 T372 compound chromosome,clones
R131 T370 T371 amod bacterial,artificial
R132 T371 T369 amod artificial,chromosome
R133 T372 T367 pobj clones,from
R134 T373 T363 prep to,leads
R135 T374 T375 amod specific,activation
R136 T375 T373 pobj activation,to
R137 T376 T375 cc or,activation
R138 T377 T375 conj inactivation,activation
R139 T378 T375 prep of,activation
R140 T379 T380 amod floxed,genes
R141 T380 T378 pobj genes,of
R142 T381 T380 compound target,genes
R143 T382 T363 prep in,leads
R144 T383 T384 amod developing,joints
R155 T394 T392 punct ", ",cartilage
R156 T395 T392 cc and,cartilage
R157 T396 T397 det the,capsule
R158 T397 T392 conj capsule,cartilage
R159 T398 T397 compound joint,capsule
R160 T399 T363 punct .,leads
R161 T401 T402 nsubj We,used
R162 T403 T402 aux have,used
R163 T404 T405 det this,system
R164 T405 T402 dobj system,used
R165 T406 T407 aux to,test
R166 T407 T402 advcl test,used
R167 T408 T409 det the,role
R168 T409 T407 dobj role,test
R169 T410 T409 prep of,role
R170 T411 T412 compound BMP,signaling
R171 T412 T410 pobj signaling,of
R172 T413 T412 compound receptor,signaling
R173 T414 T409 prep in,role
R174 T415 T416 compound joint,development
R175 T416 T414 pobj development,in
R176 T417 T402 punct .,used
R177 T419 T420 nsubjpass Mice,known
R178 T421 T419 prep with,Mice
R179 T422 T423 amod null,mutations
R180 T423 T421 pobj mutations,with
R181 T424 T423 prep in,mutations
R182 T425 T424 pobj Bmpr1a,in
R183 T426 T420 auxpass are,known
R184 T427 T428 aux to,die
R185 T428 T420 xcomp die,known
R186 T429 T428 advmod early,die
R187 T430 T429 prep in,early
R188 T431 T430 pobj embryogenesis,in
R189 T432 T428 prep with,die
R196 T441 T442 det a,allele
R197 T442 T440 dobj allele,combining
R198 T443 T442 amod floxed,allele
R199 T444 T442 compound Bmpr1a,allele
R200 T445 T440 prep with,combining
R201 T446 T447 det the,driver
R202 T447 T445 pobj driver,with
R203 T448 T449 compound Gdf5,Cre
R204 T449 T447 compound Cre,driver
R205 T450 T449 punct -,Cre
R206 T451 T452 det this,lethality
R207 T452 T438 dobj lethality,bypasses
R208 T453 T452 amod embryonic,lethality
R209 T454 T438 punct ", ",bypasses
R210 T455 T438 cc and,bypasses
R211 T456 T438 conj leads,bypasses
R212 T457 T456 prep to,leads
R215 T460 T461 amod postnatal,development
R216 T461 T458 conj development,birth
R217 T462 T458 prep of,birth
R218 T463 T462 pobj mice,of
R219 T464 T463 acl missing,mice
R220 T465 T466 det the,gene
R221 T466 T464 dobj gene,missing
R222 T467 T466 compound Bmpr1a,gene
R231 T478 T476 pobj body,in
R232 T479 T475 advmod normally,form
R233 T480 T475 prep in,form
R234 T481 T482 det the,absence
R235 T482 T480 pobj absence,in
R236 T483 T482 prep of,absence
R237 T484 T485 compound Bmpr1a,receptor
R238 T485 T486 compound receptor,function
R239 T486 T483 pobj function,of
R240 T487 T475 punct .,form
R241 T489 T490 advmod However,wears
R242 T491 T490 punct ", ",wears
R243 T492 T493 amod articular,cartilage
R244 T493 T490 nsubj cartilage,wears
R245 T494 T493 prep within,cartilage
R246 T495 T496 det the,joints
R247 T496 T494 pobj joints,within
R248 T497 T490 advmod gradually,wears
R249 T498 T490 prt away,wears
R250 T499 T490 prep in,wears
R251 T500 T501 nmod receptor,mice
R252 T501 T499 pobj mice,in
R253 T502 T500 punct -,receptor
R254 T503 T500 amod deficient,receptor
R255 T504 T490 prep after,wears
R256 T505 T504 pobj birth,after
R257 T506 T490 prep in,wears
R258 T507 T508 det a,process
R259 T508 T506 pobj process,in
R260 T509 T508 acl resembling,process
R261 T510 T511 amod human,osteoarthritis
R262 T511 T509 dobj osteoarthritis,resembling
R263 T512 T490 punct .,wears
R264 T514 T515 compound Gdf5,Cre
R265 T515 T517 compound Cre,mice
R266 T516 T515 punct -,Cre
R267 T517 T518 nsubj mice,provide
R268 T519 T520 det a,system
R269 T520 T518 dobj system,provide
R270 T521 T520 amod general,system
R271 T522 T523 dep that,used
R272 T523 T520 relcl used,system
R273 T524 T523 aux can,used
R274 T525 T523 auxpass be,used
R275 T526 T527 aux to,test
R276 T527 T523 advcl test,used
R277 T528 T529 det the,role
R278 T529 T527 dobj role,test
R279 T530 T529 prep of,role
R280 T531 T530 pobj genes,of
R281 T532 T529 prep in,role
R282 T533 T534 amod articular,regions
R283 T534 T532 pobj regions,in
R284 T535 T518 punct .,provide
R285 T537 T538 compound BMP,receptor
R286 T538 T539 compound receptor,signaling
R287 T539 T540 nsubjpass signaling,required
R288 T541 T540 auxpass is,required
R289 T542 T543 preconj not,for
R290 T543 T540 prep for,required
R291 T544 T542 advmod only,not
R292 T545 T546 amod early,development
R310 T563 T540 punct .,required
R311 T565 T566 amod Genetic,variation
R312 T566 T567 nsubj variation,be
R313 T568 T566 prep in,variation
R314 T569 T570 det the,strength
R315 T570 T568 pobj strength,in
R316 T571 T570 prep of,strength
R317 T572 T573 compound BMP,receptor
R318 T573 T574 compound receptor,signaling
R319 T574 T571 pobj signaling,of
R320 T575 T567 aux may,be
R321 T576 T577 det an,factor
R322 T577 T567 attr factor,be
R323 T578 T577 amod important,factor
R324 T579 T577 compound risk,factor
R325 T580 T567 prep in,be
R326 T581 T582 amod human,osteoarthritis
R327 T582 T580 pobj osteoarthritis,in
R328 T583 T567 punct ", ",be
R329 T584 T567 cc and,be
R330 T585 T586 nsubjpass treatments,investigated
R331 T586 T567 conj investigated,be
R332 T587 T588 dep that,mimic
R333 T588 T585 relcl mimic,treatments
R334 T589 T588 cc or,mimic
R335 T590 T588 conj augment,mimic
R336 T591 T592 compound BMP,receptor
R337 T592 T593 compound receptor,signaling
R338 T593 T590 dobj signaling,augment
R339 T594 T586 aux should,investigated
R340 T595 T586 auxpass be,investigated
R341 T596 T586 prep as,investigated
R342 T597 T598 det a,strategy
R343 T598 T596 pobj strategy,as
R344 T599 T598 amod possible,strategy
R345 T600 T598 amod therapeutic,strategy
R346 T601 T598 prep for,strategy
R347 T602 T601 pcomp maintaining,for
R348 T603 T604 det the,health
R349 T604 T602 dobj health,maintaining
R350 T605 T604 prep of,health
R351 T606 T607 compound joint,linings
R352 T607 T605 pobj linings,of
R353 T608 T586 punct .,investigated
R94 T331 T327 parataxis member,gene

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T141 695-705 GO_SO_EXT:chromosome denotes chromosome
T147 0-19 UBERON:0010996 denotes Articular cartilage
T148 117-123 NCBITaxon:9606 denotes people
T149 152-161 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T150 217-226 UBERON_EXT:cartilage_element_or_tissue denotes cartilage
T151 254-259 UBERON:0001474 denotes bones
T152 263-268 UBERON:0004905 denotes joint
T153 336-340 SO_EXT:0000704 denotes gene
T154 336-351 GO:0010467 denotes gene expression
T155 373-379 UBERON:0000479 denotes tissue
T156 417-427 GO:0065007 denotes regulatory
T157 449-454 NCBITaxon:10088 denotes mouse
T158 455-459 PR_EXT:000000281 denotes Gdf5
T159 460-464 SO_EXT:0000704 denotes gene
T160 468-472 UBERON_EXT:bone_element_or_tissue denotes bone
T161 468-486 GO:0060349 denotes bone morphogenetic
T162 468-494 PR_EXT:000000034 denotes bone morphogenetic protein
T163 487-494 CHEBI_PR_EXT:protein denotes protein
T164 496-499 PR_EXT:000000034 denotes BMP
T165 531-536 NCBITaxon:10088 denotes mouse
T166 593-598 SO_EXT:0000704 denotes genes
T167 626-632 UBERON:0004905 denotes joints
T168 634-644 GO:0010467 denotes Expression
T169 652-663 GO_EXT:recombinase denotes recombinase
T170 669-673 PR_EXT:000000281 denotes Gdf5
T171 674-683 NCBITaxon:2 denotes bacterial
T172 674-705 SO_EXT:0000153 denotes bacterial artificial chromosome
T173 706-712 SO_EXT:sequence_cloned_entity denotes clones
T174 761-767 _FRAGMENT denotes floxed
T175 775-780 SO_EXT:0000363 denotes genes
T176 795-801 UBERON:0004905 denotes joints
T177 819-824 UBERON:0004905 denotes joint
T178 837-842 UBERON:0007023 denotes adult
T179 843-862 UBERON:0010996 denotes articular cartilage
T180 872-885 UBERON:0001484 denotes joint capsule
T181 932-935 PR_EXT:000000034 denotes BMP
T182 932-944 GO_EXT:0098821 denotes BMP receptor
T183 932-954 GO:0030509 denotes BMP receptor signaling
T184 958-963 UBERON:0004905 denotes joint
T185 977-981 NCBITaxon:10088 denotes Mice
T186 987-991 SO_EXT:sequence_nullness denotes null
T187 992-1001 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T188 1005-1011 PR_EXT:000000035 denotes Bmpr1a
T189 1025-1028 GO:0016265 denotes die
T190 1038-1051 GO:0009790 denotes embryogenesis
T191 1096-1102 SO:0000359 denotes floxed
T192 1103-1109 PR_EXT:000000035 denotes Bmpr1a
T193 1110-1116 SO_EXT:0001023 denotes allele
T194 1126-1130 PR_EXT:000000281 denotes Gdf5
T195 1156-1165 UBERON:0000922 denotes embryonic
T196 1166-1175 GO_EXT:fatality_or_lethality denotes lethality
T197 1190-1195 GO:0007567 denotes birth
T198 1204-1209 GO:0007567 denotes natal
T199 1225-1229 NCBITaxon:10088 denotes mice
T200 1242-1248 PR_EXT:000000035 denotes Bmpr1a
T201 1249-1253 SO_EXT:0000704 denotes gene
T202 1257-1266 UBERON:0004905 denotes articular
T203 1281-1287 UBERON:0004905 denotes joints
T204 1295-1299 UBERON_EXT:body denotes body
T205 1332-1338 PR_EXT:000000035 denotes Bmpr1a
T206 1339-1347 GO_EXT:0004872 denotes receptor
T207 1367-1386 UBERON:0010996 denotes articular cartilage
T208 1398-1404 UBERON:0004905 denotes joints
T209 1429-1437 GO_EXT:0004872 denotes receptor
T210 1448-1452 NCBITaxon:10088 denotes mice
T211 1459-1464 GO:0007567 denotes birth
T212 1489-1494 NCBITaxon:9606 denotes human
T213 1511-1515 PR_EXT:000000281 denotes Gdf5
T214 1520-1524 NCBITaxon:10088 denotes mice
T215 1587-1592 SO_EXT:0000704 denotes genes
T216 1596-1605 UBERON:0004905 denotes articular
T217 1615-1618 PR_EXT:000000034 denotes BMP
T218 1615-1627 GO_EXT:0098821 denotes BMP receptor
T219 1615-1637 GO:0030509 denotes BMP receptor signaling
T220 1669-1680 _FRAGMENT denotes development
T221 1694-1696 _FRAGMENT denotes of
T222 1706-1713 GO:0009888 denotes tissues
T223 1685-1696 _FRAGMENT denotes creation of
T224 1706-1713 UBERON:0000479 denotes tissues
T225 1751-1770 UBERON:0010996 denotes articular cartilage
T226 1777-1782 GO:0007567 denotes birth
T227 1784-1791 SO_EXT:0000704 denotes Genetic
T228 1792-1801 SO_EXT:sequence_variation_entity_or_quality denotes variation
T229 1821-1824 PR_EXT:000000034 denotes BMP
T230 1821-1833 GO_EXT:0098821 denotes BMP receptor
T231 1821-1843 GO:0030509 denotes BMP receptor signaling
T232 1879-1884 NCBITaxon:9606 denotes human
T233 1938-1941 PR_EXT:000000034 denotes BMP
T234 1938-1950 GO_EXT:0098821 denotes BMP receptor
T235 1938-1960 GO:0030509 denotes BMP receptor signaling
T236 2049-2054 UBERON:0004905 denotes joint
R5 T175 T174 _lexicallyChainedTo genes,floxed
R6 T221 T220 _lexicallyChainedTo of,development
R7 T222 T221 _lexicallyChainedTo tissues,of
R8 T222 T223 _lexicallyChainedTo tissues,creation of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T68 0-19 UBERON:0010996 denotes Articular cartilage
T69 117-123 NCBITaxon:9606 denotes people
T70 254-259 UBERON:0001474 denotes bones
T71 263-268 UBERON:0004905 denotes joint
T72 336-340 SO:0000704 denotes gene
T73 336-351 GO:0010467 denotes gene expression
T74 373-379 UBERON:0000479 denotes tissue
T75 417-427 GO:0065007 denotes regulatory
T76 449-454 NCBITaxon:10088 denotes mouse
T77 455-459 PR:000000281 denotes Gdf5
T78 460-464 SO:0000704 denotes gene
T79 468-486 GO:0060349 denotes bone morphogenetic
T80 468-494 PR:000000034 denotes bone morphogenetic protein
T81 496-499 PR:000000034 denotes BMP
T82 531-536 NCBITaxon:10088 denotes mouse
T83 593-598 SO:0000704 denotes genes
T84 626-632 UBERON:0004905 denotes joints
T85 634-644 GO:0010467 denotes Expression
T86 669-673 PR:000000281 denotes Gdf5
T87 674-683 NCBITaxon:2 denotes bacterial
T88 674-705 SO:0000153 denotes bacterial artificial chromosome
T89 761-767 _FRAGMENT denotes floxed
T90 775-780 SO:0000363 denotes genes
T91 795-801 UBERON:0004905 denotes joints
T92 819-824 UBERON:0004905 denotes joint
T93 837-842 UBERON:0007023 denotes adult
T94 843-862 UBERON:0010996 denotes articular cartilage
T95 872-885 UBERON:0001484 denotes joint capsule
T96 932-935 PR:000000034 denotes BMP
T97 932-954 GO:0030509 denotes BMP receptor signaling
T98 958-963 UBERON:0004905 denotes joint
T99 977-981 NCBITaxon:10088 denotes Mice
T100 1005-1011 PR:000000035 denotes Bmpr1a
T101 1025-1028 GO:0016265 denotes die
T102 1038-1051 GO:0009790 denotes embryogenesis
T103 1096-1102 SO:0000359 denotes floxed
T104 1103-1109 PR:000000035 denotes Bmpr1a
T105 1110-1116 SO:0001023 denotes allele
T106 1126-1130 PR:000000281 denotes Gdf5
T107 1156-1165 UBERON:0000922 denotes embryonic
T108 1190-1195 GO:0007567 denotes birth
T109 1204-1209 GO:0007567 denotes natal
T110 1225-1229 NCBITaxon:10088 denotes mice
T111 1242-1248 PR:000000035 denotes Bmpr1a
T112 1249-1253 SO:0000704 denotes gene
T113 1257-1266 UBERON:0004905 denotes articular
T114 1281-1287 UBERON:0004905 denotes joints
T115 1332-1338 PR:000000035 denotes Bmpr1a
T116 1367-1386 UBERON:0010996 denotes articular cartilage
T117 1398-1404 UBERON:0004905 denotes joints
T118 1448-1452 NCBITaxon:10088 denotes mice
T119 1459-1464 GO:0007567 denotes birth
T120 1489-1494 NCBITaxon:9606 denotes human
T121 1511-1515 PR:000000281 denotes Gdf5
T122 1520-1524 NCBITaxon:10088 denotes mice
T123 1587-1592 SO:0000704 denotes genes
T124 1596-1605 UBERON:0004905 denotes articular
T125 1615-1618 PR:000000034 denotes BMP
T126 1615-1637 GO:0030509 denotes BMP receptor signaling
T127 1669-1680 _FRAGMENT denotes development
T128 1694-1696 _FRAGMENT denotes of
T129 1706-1713 GO:0009888 denotes tissues
T130 1685-1696 _FRAGMENT denotes creation of
T131 1706-1713 UBERON:0000479 denotes tissues
T132 1751-1770 UBERON:0010996 denotes articular cartilage
T133 1777-1782 GO:0007567 denotes birth
T134 1784-1791 SO:0000704 denotes Genetic
T135 1821-1824 PR:000000034 denotes BMP
T136 1821-1843 GO:0030509 denotes BMP receptor signaling
T137 1879-1884 NCBITaxon:9606 denotes human
T138 1938-1941 PR:000000034 denotes BMP
T139 1938-1960 GO:0030509 denotes BMP receptor signaling
T140 2049-2054 UBERON:0004905 denotes joint
R1 T90 T89 _lexicallyChainedTo genes,floxed
R2 T128 T127 _lexicallyChainedTo of,development
R3 T129 T128 _lexicallyChainedTo tissues,of
R4 T129 T130 _lexicallyChainedTo tissues,creation of