PMC:523229 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T9671	42844-42848	IN	denotes	that
T237	0-3	NN	denotes	BMP
T238	4-12	NN	denotes	Receptor
T239	0-83	sentence	denotes	BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage
T240	13-22	NN	denotes	Signaling
T241	26-34	VBN	denotes	Required
T242	23-25	VBZ	denotes	Is
T243	35-38	IN	denotes	for
T244	39-48	JJ	denotes	Postnatal
T245	49-60	NN	denotes	Maintenance
T246	61-63	IN	denotes	of
T247	64-73	JJ	denotes	Articular
T248	74-83	NN	denotes	Cartilage
T250	128-275	sentence	denotes	Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis.
T251	128-137	JJ	denotes	Articular
T252	138-147	NN	denotes	cartilage
T253	148-153	VBZ	denotes	plays
T254	154-156	DT	denotes	an
T255	167-171	NN	denotes	role
T256	157-166	JJ	denotes	essential
T257	172-174	IN	denotes	in
T258	175-181	NN	denotes	health
T259	182-185	CC	denotes	and
T260	186-194	NN	denotes	mobility
T261	194-196	,	denotes	,
T262	196-199	CC	denotes	but
T263	200-202	VBZ	denotes	is
T264	214-221	VBN	denotes	damaged
T265	203-213	RB	denotes	frequently
T266	222-224	CC	denotes	or
T267	225-229	VBN	denotes	lost
T268	230-232	IN	denotes	in
T269	233-241	NNS	denotes	millions
T270	242-244	IN	denotes	of
T271	245-251	NNS	denotes	people
T272	252-256	WDT	denotes	that
T273	257-264	VBP	denotes	develop
T274	265-274	NN	denotes	arthritis
T275	274-275	.	denotes	.
T276	275-532	sentence	denotes	The molecular mechanisms that create and maintain this thin layer of cartilage that covers the surface of bones in joint regions are poorly understood, in part because tools to manipulate gene expression specifically in this tissue have not been available.
T277	276-279	DT	denotes	The
T278	290-300	NNS	denotes	mechanisms
T279	280-289	JJ	denotes	molecular
T280	416-426	VBN	denotes	understood
T281	301-305	WDT	denotes	that
T282	306-312	VBP	denotes	create
T283	313-316	CC	denotes	and
T284	317-325	VBP	denotes	maintain
T285	326-330	DT	denotes	this
T286	336-341	NN	denotes	layer
T287	331-335	JJ	denotes	thin
T288	342-344	IN	denotes	of
T289	345-354	NN	denotes	cartilage
T290	355-359	WDT	denotes	that
T291	360-366	VBZ	denotes	covers
T292	367-370	DT	denotes	the
T293	371-378	NN	denotes	surface
T294	379-381	IN	denotes	of
T295	382-387	NNS	denotes	bones
T296	388-390	IN	denotes	in
T297	391-396	NN	denotes	joint
T298	397-404	NNS	denotes	regions
T299	405-408	VBP	denotes	are
T300	409-415	RB	denotes	poorly
T301	426-428	,	denotes	,
T302	428-430	IN	denotes	in
T303	517-521	VBN	denotes	been
T304	431-435	JJ	denotes	part
T305	436-443	IN	denotes	because
T306	444-449	NNS	denotes	tools
T307	450-452	TO	denotes	to
T308	453-463	VB	denotes	manipulate
T309	464-468	NN	denotes	gene
T310	469-479	NN	denotes	expression
T311	480-492	RB	denotes	specifically
T312	493-495	IN	denotes	in
T313	496-500	DT	denotes	this
T314	501-507	NN	denotes	tissue
T315	508-512	VBP	denotes	have
T316	513-516	RB	denotes	not
T317	522-531	JJ	denotes	available
T318	531-532	.	denotes	.
T319	532-761	sentence	denotes	Here we use regulatory information from the mouse Gdf5 gene (a bone morphogenetic protein [BMP] family member) to develop new mouse lines that can be used to either activate or inactivate genes specifically in developing joints.
T320	533-537	RB	denotes	Here
T321	541-544	VBP	denotes	use
T322	538-540	PRP	denotes	we
T323	545-555	JJ	denotes	regulatory
T324	556-567	NN	denotes	information
T325	568-572	IN	denotes	from
T326	573-576	DT	denotes	the
T327	588-592	NN	denotes	gene
T328	577-582	NN	denotes	mouse
T329	583-587	NN	denotes	Gdf5
T330	593-594	-LRB-	denotes	(
T331	636-642	NN	denotes	member
T332	594-595	DT	denotes	a
T333	596-600	NN	denotes	bone
T334	615-622	NN	denotes	protein
T335	601-614	JJ	denotes	morphogenetic
T336	623-624	-LRB-	denotes	[
T337	624-627	NN	denotes	BMP
T338	627-628	-RRB-	denotes	]
T339	629-635	NN	denotes	family
T340	642-643	-RRB-	denotes	)
T341	644-646	TO	denotes	to
T342	647-654	VB	denotes	develop
T343	655-658	JJ	denotes	new
T344	665-670	NNS	denotes	lines
T345	659-664	NN	denotes	mouse
T346	671-675	WDT	denotes	that
T347	683-687	VBN	denotes	used
T348	676-679	MD	denotes	can
T349	680-682	VB	denotes	be
T350	688-690	TO	denotes	to
T351	698-706	VB	denotes	activate
T352	691-697	CC	denotes	either
T353	707-709	CC	denotes	or
T354	710-720	VB	denotes	inactivate
T355	721-726	NNS	denotes	genes
T356	727-739	RB	denotes	specifically
T357	740-742	IN	denotes	in
T358	743-753	VBG	denotes	developing
T359	754-760	NNS	denotes	joints
T360	760-761	.	denotes	.
T361	761-1014	sentence	denotes	Expression of Cre recombinase from Gdf5 bacterial artificial chromosome clones leads to specific activation or inactivation of floxed target genes in developing joints, including early joint interzones, adult articular cartilage, and the joint capsule.
T362	762-772	NN	denotes	Expression
T363	841-846	VBZ	denotes	leads
T364	773-775	IN	denotes	of
T365	776-779	NN	denotes	Cre
T366	780-791	NN	denotes	recombinase
T367	792-796	IN	denotes	from
T368	797-801	NN	denotes	Gdf5
T369	823-833	NN	denotes	chromosome
T370	802-811	JJ	denotes	bacterial
T371	812-822	JJ	denotes	artificial
T372	834-840	NNS	denotes	clones
T373	847-849	IN	denotes	to
T374	850-858	JJ	denotes	specific
T375	859-869	NN	denotes	activation
T376	870-872	CC	denotes	or
T377	873-885	NN	denotes	inactivation
T378	886-888	IN	denotes	of
T379	889-895	VBN	denotes	floxed
T380	903-908	NNS	denotes	genes
T381	896-902	NN	denotes	target
T382	909-911	IN	denotes	in
T383	912-922	VBG	denotes	developing
T384	923-929	NNS	denotes	joints
T385	929-931	,	denotes	,
T386	931-940	VBG	denotes	including
T387	941-946	JJ	denotes	early
T388	953-963	NNS	denotes	interzones
T389	947-952	NN	denotes	joint
T390	963-965	,	denotes	,
T391	965-970	NN	denotes	adult
T392	981-990	NN	denotes	cartilage
T393	971-980	JJ	denotes	articular
T394	990-992	,	denotes	,
T395	992-995	CC	denotes	and
T396	996-999	DT	denotes	the
T397	1006-1013	NN	denotes	capsule
T398	1000-1005	NN	denotes	joint
T399	1013-1014	.	denotes	.
T400	1014-1104	sentence	denotes	We have used this system to test the role of BMP receptor signaling in joint development.
T401	1015-1017	PRP	denotes	We
T402	1023-1027	VBN	denotes	used
T403	1018-1022	VBP	denotes	have
T404	1028-1032	DT	denotes	this
T405	1033-1039	NN	denotes	system
T406	1040-1042	TO	denotes	to
T407	1043-1047	VB	denotes	test
T408	1048-1051	DT	denotes	the
T409	1052-1056	NN	denotes	role
T410	1057-1059	IN	denotes	of
T411	1060-1063	NN	denotes	BMP
T412	1073-1082	NN	denotes	signaling
T413	1064-1072	NN	denotes	receptor
T414	1083-1085	IN	denotes	in
T415	1086-1091	NN	denotes	joint
T416	1092-1103	NN	denotes	development
T417	1103-1104	.	denotes	.
T418	1104-1202	sentence	denotes	Mice with null mutations in Bmpr1a are known to die early in embryogenesis with multiple defects.
T419	1105-1109	NNS	denotes	Mice
T420	1144-1149	VBN	denotes	known
T421	1110-1114	IN	denotes	with
T422	1115-1119	JJ	denotes	null
T423	1120-1129	NNS	denotes	mutations
T424	1130-1132	IN	denotes	in
T425	1133-1139	NN	denotes	Bmpr1a
T426	1140-1143	VBP	denotes	are
T427	1150-1152	TO	denotes	to
T428	1153-1156	VB	denotes	die
T429	1157-1162	RB	denotes	early
T430	1163-1165	IN	denotes	in
T431	1166-1179	NN	denotes	embryogenesis
T432	1180-1184	IN	denotes	with
T433	1185-1193	JJ	denotes	multiple
T434	1194-1201	NNS	denotes	defects
T435	1201-1202	.	denotes	.
T436	1202-1403	sentence	denotes	However, combining a floxed Bmpr1a allele with the Gdf5-Cre driver bypasses this embryonic lethality, and leads to birth and postnatal development of mice missing the Bmpr1a gene in articular regions.
T437	1203-1210	RB	denotes	However
T438	1270-1278	VBZ	denotes	bypasses
T439	1210-1212	,	denotes	,
T440	1212-1221	VBG	denotes	combining
T441	1222-1223	DT	denotes	a
T442	1238-1244	NN	denotes	allele
T443	1224-1230	VBN	denotes	floxed
T444	1231-1237	NN	denotes	Bmpr1a
T445	1245-1249	IN	denotes	with
T446	1250-1253	DT	denotes	the
T447	1263-1269	NN	denotes	driver
T448	1254-1258	NN	denotes	Gdf5
T449	1259-1262	NN	denotes	Cre
T450	1258-1259	HYPH	denotes	-
T451	1279-1283	DT	denotes	this
T452	1294-1303	NN	denotes	lethality
T453	1284-1293	JJ	denotes	embryonic
T454	1303-1305	,	denotes	,
T455	1305-1308	CC	denotes	and
T456	1309-1314	VBZ	denotes	leads
T457	1315-1317	IN	denotes	to
T458	1318-1323	NN	denotes	birth
T459	1324-1327	CC	denotes	and
T460	1328-1337	JJ	denotes	postnatal
T461	1338-1349	NN	denotes	development
T462	1350-1352	IN	denotes	of
T463	1353-1357	NNS	denotes	mice
T464	1358-1365	VBG	denotes	missing
T465	1366-1369	DT	denotes	the
T466	1377-1381	NN	denotes	gene
T467	1370-1376	NN	denotes	Bmpr1a
T468	1382-1384	IN	denotes	in
T469	1385-1394	JJ	denotes	articular
T470	1395-1402	NNS	denotes	regions
T471	1402-1403	.	denotes	.
T472	1403-1485	sentence	denotes	Most joints in the body form normally in the absence of Bmpr1a receptor function.
T473	1404-1408	JJS	denotes	Most
T474	1409-1415	NNS	denotes	joints
T475	1428-1432	VBP	denotes	form
T476	1416-1418	IN	denotes	in
T477	1419-1422	DT	denotes	the
T478	1423-1427	NN	denotes	body
T479	1433-1441	RB	denotes	normally
T480	1442-1444	IN	denotes	in
T481	1445-1448	DT	denotes	the
T482	1449-1456	NN	denotes	absence
T483	1457-1459	IN	denotes	of
T484	1460-1466	NN	denotes	Bmpr1a
T485	1467-1475	NN	denotes	receptor
T486	1476-1484	NN	denotes	function
T487	1484-1485	.	denotes	.
T488	1485-1638	sentence	denotes	However, articular cartilage within the joints gradually wears away in receptor-deficient mice after birth in a process resembling human osteoarthritis.
T489	1486-1493	RB	denotes	However
T490	1543-1548	VBZ	denotes	wears
T491	1493-1495	,	denotes	,
T492	1495-1504	JJ	denotes	articular
T493	1505-1514	NN	denotes	cartilage
T494	1515-1521	IN	denotes	within
T495	1522-1525	DT	denotes	the
T496	1526-1532	NNS	denotes	joints
T497	1533-1542	RB	denotes	gradually
T498	1549-1553	RP	denotes	away
T499	1554-1556	IN	denotes	in
T500	1557-1565	NN	denotes	receptor
T501	1576-1580	NNS	denotes	mice
T502	1565-1566	HYPH	denotes	-
T503	1566-1575	JJ	denotes	deficient
T504	1581-1586	IN	denotes	after
T505	1587-1592	NN	denotes	birth
T506	1593-1595	IN	denotes	in
T507	1596-1597	DT	denotes	a
T508	1598-1605	NN	denotes	process
T509	1606-1616	VBG	denotes	resembling
T510	1617-1622	JJ	denotes	human
T511	1623-1637	NN	denotes	osteoarthritis
T512	1637-1638	.	denotes	.
T513	1638-1742	sentence	denotes	Gdf5-Cre mice provide a general system that can be used to test the role of genes in articular regions.
T514	1639-1643	NN	denotes	Gdf5
T515	1644-1647	NN	denotes	Cre
T516	1643-1644	HYPH	denotes	-
T517	1648-1652	NNS	denotes	mice
T518	1653-1660	VBP	denotes	provide
T519	1661-1662	DT	denotes	a
T520	1671-1677	NN	denotes	system
T521	1663-1670	JJ	denotes	general
T522	1678-1682	WDT	denotes	that
T523	1690-1694	VBN	denotes	used
T524	1683-1686	MD	denotes	can
T525	1687-1689	VB	denotes	be
T526	1695-1697	TO	denotes	to
T527	1698-1702	VB	denotes	test
T528	1703-1706	DT	denotes	the
T529	1707-1711	NN	denotes	role
T530	1712-1714	IN	denotes	of
T531	1715-1720	NNS	denotes	genes
T532	1721-1723	IN	denotes	in
T533	1724-1733	JJ	denotes	articular
T534	1734-1741	NNS	denotes	regions
T535	1741-1742	.	denotes	.
T536	1742-1911	sentence	denotes	BMP receptor signaling is required not only for early development and creation of multiple tissues, but also for ongoing maintenance of articular cartilage after birth.
T537	1743-1746	NN	denotes	BMP
T538	1747-1755	NN	denotes	receptor
T539	1756-1765	NN	denotes	signaling
T540	1769-1777	VBN	denotes	required
T541	1766-1768	VBZ	denotes	is
T542	1778-1781	RB	denotes	not
T543	1787-1790	IN	denotes	for
T544	1782-1786	RB	denotes	only
T545	1791-1796	JJ	denotes	early
T546	1797-1808	NN	denotes	development
T547	1809-1812	CC	denotes	and
T548	1813-1821	NN	denotes	creation
T549	1822-1824	IN	denotes	of
T550	1825-1833	JJ	denotes	multiple
T551	1834-1841	NNS	denotes	tissues
T552	1841-1843	,	denotes	,
T553	1843-1846	CC	denotes	but
T554	1847-1851	RB	denotes	also
T555	1852-1855	IN	denotes	for
T556	1856-1863	JJ	denotes	ongoing
T557	1864-1875	NN	denotes	maintenance
T558	1876-1878	IN	denotes	of
T559	1879-1888	JJ	denotes	articular
T560	1889-1898	NN	denotes	cartilage
T561	1899-1904	IN	denotes	after
T562	1905-1910	NN	denotes	birth
T563	1910-1911	.	denotes	.
T564	1911-2191	sentence	denotes	Genetic variation in the strength of BMP receptor signaling may be an important risk factor in human osteoarthritis, and treatments that mimic or augment BMP receptor signaling should be investigated as a possible therapeutic strategy for maintaining the health of joint linings.
T565	1912-1919	JJ	denotes	Genetic
T566	1920-1929	NN	denotes	variation
T567	1976-1978	VB	denotes	be
T568	1930-1932	IN	denotes	in
T569	1933-1936	DT	denotes	the
T570	1937-1945	NN	denotes	strength
T571	1946-1948	IN	denotes	of
T572	1949-1952	NN	denotes	BMP
T573	1953-1961	NN	denotes	receptor
T574	1962-1971	NN	denotes	signaling
T575	1972-1975	MD	denotes	may
T576	1979-1981	DT	denotes	an
T577	1997-2003	NN	denotes	factor
T578	1982-1991	JJ	denotes	important
T579	1992-1996	NN	denotes	risk
T580	2004-2006	IN	denotes	in
T581	2007-2012	JJ	denotes	human
T582	2013-2027	NN	denotes	osteoarthritis
T583	2027-2029	,	denotes	,
T584	2029-2032	CC	denotes	and
T585	2033-2043	NNS	denotes	treatments
T586	2099-2111	VBN	denotes	investigated
T587	2044-2048	WDT	denotes	that
T588	2049-2054	VBP	denotes	mimic
T589	2055-2057	CC	denotes	or
T590	2058-2065	VBP	denotes	augment
T591	2066-2069	NN	denotes	BMP
T592	2070-2078	NN	denotes	receptor
T593	2079-2088	NN	denotes	signaling
T594	2089-2095	MD	denotes	should
T595	2096-2098	VB	denotes	be
T596	2112-2114	IN	denotes	as
T597	2115-2116	DT	denotes	a
T598	2138-2146	NN	denotes	strategy
T599	2117-2125	JJ	denotes	possible
T600	2126-2137	JJ	denotes	therapeutic
T601	2147-2150	IN	denotes	for
T602	2151-2162	VBG	denotes	maintaining
T603	2163-2166	DT	denotes	the
T604	2167-2173	NN	denotes	health
T605	2174-2176	IN	denotes	of
T606	2177-2182	NN	denotes	joint
T607	2183-2190	NNS	denotes	linings
T608	2190-2191	.	denotes	.
T1083	2378-2382	JJ	denotes	Thin
T1084	2383-2389	NNS	denotes	layers
T1085	2413-2417	VBP	denotes	line
T1086	2390-2392	IN	denotes	of
T1087	2393-2402	JJ	denotes	articular
T1088	2403-2412	NN	denotes	cartilage
T1089	2418-2421	DT	denotes	the
T1090	2422-2427	NNS	denotes	bones
T1091	2428-2430	IN	denotes	of
T1092	2431-2439	JJ	denotes	synovial
T1093	2440-2446	NNS	denotes	joints
T1094	2447-2450	CC	denotes	and
T1095	2451-2458	VBP	denotes	provide
T1096	2459-2460	DT	denotes	a
T1097	2484-2493	NN	denotes	structure
T1098	2461-2467	JJ	denotes	smooth
T1099	2467-2469	,	denotes	,
T1100	2469-2473	NN	denotes	wear
T1101	2474-2483	JJ	denotes	resistant
T1102	2473-2474	HYPH	denotes	-
T1103	2494-2498	WDT	denotes	that
T1104	2499-2506	VBZ	denotes	reduces
T1105	2507-2515	NN	denotes	friction
T1106	2516-2519	CC	denotes	and
T1107	2520-2527	VBZ	denotes	absorbs
T1108	2528-2534	NN	denotes	impact
T1109	2535-2541	NNS	denotes	forces
T1110	2542-2543	-LRB-	denotes	(
T1111	2543-2549	NNP	denotes	Brandt
T1112	2550-2552	FW	denotes	et
T1113	2553-2556	FW	denotes	al.
T1114	2557-2561	CD	denotes	1998
T1115	2561-2562	-RRB-	denotes	)
T1116	2562-2563	.	denotes	.
T1117	2563-2725	sentence	denotes	Loss or damage to articular cartilage is a hallmark of arthritic diseases and is one of the most common reasons that both young and old adults seek medical care.
T1118	2564-2568	NN	denotes	Loss
T1119	2602-2604	VBZ	denotes	is
T1120	2569-2571	CC	denotes	or
T1121	2572-2578	NN	denotes	damage
T1122	2579-2581	IN	denotes	to
T1123	2582-2591	JJ	denotes	articular
T1124	2592-2601	NN	denotes	cartilage
T1125	2605-2606	DT	denotes	a
T1126	2607-2615	NN	denotes	hallmark
T1127	2616-2618	IN	denotes	of
T1128	2619-2628	JJ	denotes	arthritic
T1129	2629-2637	NNS	denotes	diseases
T1130	2638-2641	CC	denotes	and
T1131	2642-2644	VBZ	denotes	is
T1132	2645-2648	CD	denotes	one
T1133	2649-2651	IN	denotes	of
T1134	2652-2655	DT	denotes	the
T1135	2668-2675	NNS	denotes	reasons
T1136	2656-2660	RBS	denotes	most
T1137	2661-2667	JJ	denotes	common
T1138	2676-2680	IN	denotes	that
T1139	2707-2711	VBP	denotes	seek
T1140	2681-2685	CC	denotes	both
T1141	2686-2691	JJ	denotes	young
T1142	2700-2706	NNS	denotes	adults
T1143	2692-2695	CC	denotes	and
T1144	2696-2699	JJ	denotes	old
T1145	2712-2719	JJ	denotes	medical
T1146	2720-2724	NN	denotes	care
T1147	2724-2725	.	denotes	.
T1148	2725-2884	sentence	denotes	Millions of people are afflicted with arthritis, and it ultimately affects more than half of people over the age of 65 (Badley 1995; Yelin and Callahan 1995).
T1149	2726-2734	NNS	denotes	Millions
T1150	2745-2748	VBP	denotes	are
T1151	2735-2737	IN	denotes	of
T1152	2738-2744	NNS	denotes	people
T1153	2749-2758	JJ	denotes	afflicted
T1154	2759-2763	IN	denotes	with
T1155	2764-2773	NN	denotes	arthritis
T1156	2773-2775	,	denotes	,
T1157	2775-2778	CC	denotes	and
T1158	2779-2781	PRP	denotes	it
T1159	2793-2800	VBZ	denotes	affects
T1160	2782-2792	RB	denotes	ultimately
T1161	2801-2805	JJR	denotes	more
T1162	2811-2815	NN	denotes	half
T1163	2806-2810	IN	denotes	than
T1164	2816-2818	IN	denotes	of
T1165	2819-2825	NNS	denotes	people
T1166	2826-2830	IN	denotes	over
T1167	2831-2834	DT	denotes	the
T1168	2835-2838	NN	denotes	age
T1169	2839-2841	IN	denotes	of
T1170	2842-2844	CD	denotes	65
T1171	2845-2846	-LRB-	denotes	(
T1172	2846-2852	NNP	denotes	Badley
T1173	2853-2857	CD	denotes	1995
T1174	2857-2858	:	denotes	;
T1175	2859-2864	NNP	denotes	Yelin
T1176	2865-2868	CC	denotes	and
T1177	2869-2877	NNP	denotes	Callahan
T1178	2878-2882	CD	denotes	1995
T1179	2882-2883	-RRB-	denotes	)
T1180	2883-2884	.	denotes	.
T1181	2884-3078	sentence	denotes	A better understanding of the molecular mechanisms that create and maintain articular cartilage is crucial for discovering the causes of joint disorders and providing useful medical treatments.
T1182	2885-2886	DT	denotes	A
T1183	2894-2907	NN	denotes	understanding
T1184	2887-2893	JJR	denotes	better
T1185	2981-2983	VBZ	denotes	is
T1186	2908-2910	IN	denotes	of
T1187	2911-2914	DT	denotes	the
T1188	2925-2935	NNS	denotes	mechanisms
T1189	2915-2924	JJ	denotes	molecular
T1190	2936-2940	WDT	denotes	that
T1191	2941-2947	VBP	denotes	create
T1192	2948-2951	CC	denotes	and
T1193	2952-2960	VBP	denotes	maintain
T1194	2961-2970	JJ	denotes	articular
T1195	2971-2980	NN	denotes	cartilage
T1196	2984-2991	JJ	denotes	crucial
T1197	2992-2995	IN	denotes	for
T1198	2996-3007	VBG	denotes	discovering
T1199	3008-3011	DT	denotes	the
T1200	3012-3018	NNS	denotes	causes
T1201	3019-3021	IN	denotes	of
T1202	3022-3027	NN	denotes	joint
T1203	3028-3037	NNS	denotes	disorders
T1204	3038-3041	CC	denotes	and
T1205	3042-3051	VBG	denotes	providing
T1206	3052-3058	JJ	denotes	useful
T1207	3067-3077	NNS	denotes	treatments
T1208	3059-3066	JJ	denotes	medical
T1209	3077-3078	.	denotes	.
T1210	3078-3233	sentence	denotes	Joint formation begins during embryogenesis, when stripes of high cell density called interzones form across developing skeletal precursors (Haines 1947).
T1211	3079-3084	NN	denotes	Joint
T1212	3085-3094	NN	denotes	formation
T1213	3095-3101	VBZ	denotes	begins
T1214	3102-3108	IN	denotes	during
T1215	3109-3122	NN	denotes	embryogenesis
T1216	3122-3124	,	denotes	,
T1217	3124-3128	WRB	denotes	when
T1218	3176-3180	VBP	denotes	form
T1219	3129-3136	NNS	denotes	stripes
T1220	3137-3139	IN	denotes	of
T1221	3140-3144	JJ	denotes	high
T1222	3150-3157	NN	denotes	density
T1223	3145-3149	NN	denotes	cell
T1224	3158-3164	VBN	denotes	called
T1225	3165-3175	NNS	denotes	interzones
T1226	3181-3187	IN	denotes	across
T1227	3188-3198	VBG	denotes	developing
T1228	3208-3218	NNS	denotes	precursors
T1229	3199-3207	JJ	denotes	skeletal
T1230	3219-3220	-LRB-	denotes	(
T1231	3220-3226	NNP	denotes	Haines
T1232	3227-3231	CD	denotes	1947
T1233	3231-3232	-RRB-	denotes	)
T1234	3232-3233	.	denotes	.
T1235	3233-3404	sentence	denotes	Programmed cell death occurs within the interzone, and a three-layered interzone forms that has two layers of higher cell density flanking a region of lower cell density.
T1236	3234-3244	VBN	denotes	Programmed
T1237	3250-3255	NN	denotes	death
T1238	3245-3249	NN	denotes	cell
T1239	3256-3262	VBZ	denotes	occurs
T1240	3263-3269	IN	denotes	within
T1241	3270-3273	DT	denotes	the
T1242	3274-3283	NN	denotes	interzone
T1243	3283-3285	,	denotes	,
T1244	3285-3288	CC	denotes	and
T1245	3289-3290	DT	denotes	a
T1246	3305-3314	NN	denotes	interzone
T1247	3291-3296	CD	denotes	three
T1248	3297-3304	VBN	denotes	layered
T1249	3296-3297	HYPH	denotes	-
T1250	3315-3320	VBZ	denotes	forms
T1251	3321-3325	WDT	denotes	that
T1252	3326-3329	VBZ	denotes	has
T1253	3330-3333	CD	denotes	two
T1254	3334-3340	NNS	denotes	layers
T1255	3341-3343	IN	denotes	of
T1256	3344-3350	JJR	denotes	higher
T1257	3356-3363	NN	denotes	density
T1258	3351-3355	NN	denotes	cell
T1259	3364-3372	VBG	denotes	flanking
T1260	3373-3374	DT	denotes	a
T1261	3375-3381	NN	denotes	region
T1262	3382-3384	IN	denotes	of
T1263	3385-3390	JJR	denotes	lower
T1264	3396-3403	NN	denotes	density
T1265	3391-3395	NN	denotes	cell
T1266	3403-3404	.	denotes	.
T1267	3404-3520	sentence	denotes	Non-joint precursors of the skeleton typically develop into cartilage, which hypertrophies and is replaced by bone.
T1268	3405-3414	NN	denotes	Non-joint
T1269	3415-3425	NNS	denotes	precursors
T1270	3452-3459	VBP	denotes	develop
T1271	3426-3428	IN	denotes	of
T1272	3429-3432	DT	denotes	the
T1273	3433-3441	NN	denotes	skeleton
T1274	3442-3451	RB	denotes	typically
T1275	3460-3464	IN	denotes	into
T1276	3465-3474	NN	denotes	cartilage
T1277	3474-3476	,	denotes	,
T1278	3476-3481	WDT	denotes	which
T1279	3482-3495	VBZ	denotes	hypertrophies
T1280	3496-3499	CC	denotes	and
T1281	3500-3502	VBZ	denotes	is
T1282	3503-3511	VBN	denotes	replaced
T1283	3512-3514	IN	denotes	by
T1284	3515-3519	NN	denotes	bone
T1285	3519-3520	.	denotes	.
T1286	3520-3718	sentence	denotes	However, cells within the high-density layers of the interzone are excluded from this process and develop into the permanent layers of articular cartilage found in the mature joint (Mitrovic 1978).
T1287	3521-3528	RB	denotes	However
T1288	3588-3596	VBN	denotes	excluded
T1289	3528-3530	,	denotes	,
T1290	3530-3535	NNS	denotes	cells
T1291	3536-3542	IN	denotes	within
T1292	3543-3546	DT	denotes	the
T1293	3560-3566	NNS	denotes	layers
T1294	3547-3551	JJ	denotes	high
T1295	3552-3559	NN	denotes	density
T1296	3551-3552	HYPH	denotes	-
T1297	3567-3569	IN	denotes	of
T1298	3570-3573	DT	denotes	the
T1299	3574-3583	NN	denotes	interzone
T1300	3584-3587	VBP	denotes	are
T1301	3597-3601	IN	denotes	from
T1302	3602-3606	DT	denotes	this
T1303	3607-3614	NN	denotes	process
T1304	3615-3618	CC	denotes	and
T1305	3619-3626	VBP	denotes	develop
T1306	3627-3631	IN	denotes	into
T1307	3632-3635	DT	denotes	the
T1308	3646-3652	NNS	denotes	layers
T1309	3636-3645	JJ	denotes	permanent
T1310	3653-3655	IN	denotes	of
T1311	3656-3665	JJ	denotes	articular
T1312	3666-3675	NN	denotes	cartilage
T1313	3676-3681	VBN	denotes	found
T1314	3682-3684	IN	denotes	in
T1315	3685-3688	DT	denotes	the
T1316	3696-3701	NN	denotes	joint
T1317	3689-3695	JJ	denotes	mature
T1318	3702-3703	-LRB-	denotes	(
T1319	3703-3711	NNP	denotes	Mitrovic
T1320	3712-3716	CD	denotes	1978
T1321	3716-3717	-RRB-	denotes	)
T1322	3717-3718	.	denotes	.
T1323	3718-3856	sentence	denotes	Studies over the last 10 y have begun to elucidate some of the signaling pathways that contribute to the early stages of joint formation.
T1324	3719-3726	NNS	denotes	Studies
T1325	3751-3756	VBN	denotes	begun
T1326	3727-3731	IN	denotes	over
T1327	3732-3735	DT	denotes	the
T1328	3744-3745	NN	denotes	y
T1329	3736-3740	JJ	denotes	last
T1330	3741-3743	CD	denotes	10
T1331	3746-3750	VBP	denotes	have
T1332	3757-3759	TO	denotes	to
T1333	3760-3769	VB	denotes	elucidate
T1334	3770-3774	DT	denotes	some
T1335	3775-3777	IN	denotes	of
T1336	3778-3781	DT	denotes	the
T1337	3792-3800	NNS	denotes	pathways
T1338	3782-3791	NN	denotes	signaling
T1339	3801-3805	WDT	denotes	that
T1340	3806-3816	VBP	denotes	contribute
T1341	3817-3819	IN	denotes	to
T1342	3820-3823	DT	denotes	the
T1343	3830-3836	NNS	denotes	stages
T1344	3824-3829	JJ	denotes	early
T1345	3837-3839	IN	denotes	of
T1346	3840-3845	NN	denotes	joint
T1347	3846-3855	NN	denotes	formation
T1348	3855-3856	.	denotes	.
T1349	3856-4061	sentence	denotes	Wnt14 is expressed in stripes at the sites where joints will form, and it is capable of inducing expression of other joint markers when misexpressed at new locations in the limb (Hartmann and Tabin 2001).
T1350	3857-3862	NN	denotes	Wnt14
T1351	3866-3875	VBN	denotes	expressed
T1352	3863-3865	VBZ	denotes	is
T1353	3876-3878	IN	denotes	in
T1354	3879-3886	NNS	denotes	stripes
T1355	3887-3889	IN	denotes	at
T1356	3890-3893	DT	denotes	the
T1357	3894-3899	NNS	denotes	sites
T1358	3900-3905	WRB	denotes	where
T1359	3918-3922	VB	denotes	form
T1360	3906-3912	NNS	denotes	joints
T1361	3913-3917	MD	denotes	will
T1362	3922-3924	,	denotes	,
T1363	3924-3927	CC	denotes	and
T1364	3928-3930	PRP	denotes	it
T1365	3931-3933	VBZ	denotes	is
T1366	3934-3941	JJ	denotes	capable
T1367	3942-3944	IN	denotes	of
T1368	3945-3953	VBG	denotes	inducing
T1369	3954-3964	NN	denotes	expression
T1370	3965-3967	IN	denotes	of
T1371	3968-3973	JJ	denotes	other
T1372	3980-3987	NNS	denotes	markers
T1373	3974-3979	NN	denotes	joint
T1374	3988-3992	WRB	denotes	when
T1375	3993-4005	VBN	denotes	misexpressed
T1376	4006-4008	IN	denotes	at
T1377	4009-4012	JJ	denotes	new
T1378	4013-4022	NNS	denotes	locations
T1379	4023-4025	IN	denotes	in
T1380	4026-4029	DT	denotes	the
T1381	4030-4034	NN	denotes	limb
T1382	4035-4036	-LRB-	denotes	(
T1383	4036-4044	NNP	denotes	Hartmann
T1384	4045-4048	CC	denotes	and
T1385	4049-4054	NNP	denotes	Tabin
T1386	4055-4059	CD	denotes	2001
T1387	4059-4060	-RRB-	denotes	)
T1388	4060-4061	.	denotes	.
T1389	4061-4383	sentence	denotes	Several members of the bone morphogenetic protein (BMP) family of secreted signaling molecules are also expressed in stripes at sites where joints will form, including those encoded by the genes Gdf5, Gdf6, Gdf7, Bmp2, and Bmp4 (Storm and Kingsley 1996; Wolfman et al. 1997; Francis-West et al. 1999; Settle et al. 2003).
T1390	4062-4069	JJ	denotes	Several
T1391	4070-4077	NNS	denotes	members
T1392	4166-4175	VBN	denotes	expressed
T1393	4078-4080	IN	denotes	of
T1394	4081-4084	DT	denotes	the
T1395	4118-4124	NN	denotes	family
T1396	4085-4089	NN	denotes	bone
T1397	4104-4111	NN	denotes	protein
T1398	4090-4103	JJ	denotes	morphogenetic
T1399	4112-4113	-LRB-	denotes	(
T1400	4113-4116	NNP	denotes	BMP
T1401	4116-4117	-RRB-	denotes	)
T1402	4125-4127	IN	denotes	of
T1403	4128-4136	VBN	denotes	secreted
T1404	4147-4156	NNS	denotes	molecules
T1405	4137-4146	NN	denotes	signaling
T1406	4157-4160	VBP	denotes	are
T1407	4161-4165	RB	denotes	also
T1408	4176-4178	IN	denotes	in
T1409	4179-4186	NNS	denotes	stripes
T1410	4187-4189	IN	denotes	at
T1411	4190-4195	NNS	denotes	sites
T1412	4196-4201	WRB	denotes	where
T1413	4214-4218	VB	denotes	form
T1414	4202-4208	NNS	denotes	joints
T1415	4209-4213	MD	denotes	will
T1416	4218-4220	,	denotes	,
T1417	4220-4229	VBG	denotes	including
T1418	4230-4235	DT	denotes	those
T1419	4236-4243	VBN	denotes	encoded
T1420	4244-4246	IN	denotes	by
T1421	4247-4250	DT	denotes	the
T1422	4251-4256	NNS	denotes	genes
T1423	4257-4261	NN	denotes	Gdf5
T1424	4261-4263	,	denotes	,
T1425	4263-4267	NN	denotes	Gdf6
T1426	4267-4269	,	denotes	,
T1427	4269-4273	NN	denotes	Gdf7
T1428	4273-4275	,	denotes	,
T1429	4275-4279	NN	denotes	Bmp2
T1430	4279-4281	,	denotes	,
T1431	4281-4284	CC	denotes	and
T1432	4285-4289	NN	denotes	Bmp4
T1433	4290-4291	-LRB-	denotes	(
T1434	4291-4296	NNP	denotes	Storm
T1435	4297-4300	CC	denotes	and
T1436	4301-4309	NNP	denotes	Kingsley
T1437	4310-4314	CD	denotes	1996
T1438	4314-4315	:	denotes	;
T1439	4316-4323	NNP	denotes	Wolfman
T1440	4324-4326	FW	denotes	et
T1441	4327-4330	FW	denotes	al.
T1442	4331-4335	CD	denotes	1997
T1443	4335-4336	:	denotes	;
T1444	4337-4344	NNP	denotes	Francis
T1445	4344-4345	HYPH	denotes	-
T1446	4345-4349	NNP	denotes	West
T1447	4350-4352	FW	denotes	et
T1448	4353-4356	FW	denotes	al.
T1449	4357-4361	CD	denotes	1999
T1450	4361-4362	:	denotes	;
T1451	4363-4369	NNP	denotes	Settle
T1452	4370-4372	FW	denotes	et
T1453	4373-4376	FW	denotes	al.
T1454	4377-4381	CD	denotes	2003
T1455	4381-4382	-RRB-	denotes	)
T1456	4382-4383	.	denotes	.
T1457	4383-4534	sentence	denotes	Of these, Gdf5 expression is most strikingly limited to regions where joints will develop and is one of the earliest known markers of joint formation.
T1458	4384-4386	IN	denotes	Of
T1459	4410-4412	VBZ	denotes	is
T1460	4387-4392	DT	denotes	these
T1461	4392-4394	,	denotes	,
T1462	4394-4398	NN	denotes	Gdf5
T1463	4399-4409	NN	denotes	expression
T1464	4413-4417	RBS	denotes	most
T1465	4418-4428	RB	denotes	strikingly
T1466	4429-4436	VBN	denotes	limited
T1467	4437-4439	IN	denotes	to
T1468	4440-4447	NNS	denotes	regions
T1469	4448-4453	WRB	denotes	where
T1470	4466-4473	VB	denotes	develop
T1471	4454-4460	NNS	denotes	joints
T1472	4461-4465	MD	denotes	will
T1473	4474-4477	CC	denotes	and
T1474	4478-4480	VBZ	denotes	is
T1475	4481-4484	CD	denotes	one
T1476	4485-4487	IN	denotes	of
T1477	4488-4491	DT	denotes	the
T1478	4507-4514	NNS	denotes	markers
T1479	4492-4500	JJS	denotes	earliest
T1480	4501-4506	VBN	denotes	known
T1481	4515-4517	IN	denotes	of
T1482	4518-4523	NN	denotes	joint
T1483	4524-4533	NN	denotes	formation
T1484	4533-4534	.	denotes	.
T1485	4534-4780	sentence	denotes	Mutations in either Gdf5 or the closely related Gdf6 gene also block formation of joints at specific locations, providing strong evidence that these molecules are essential for the joint formation process (Storm et al. 1994; Settle et al. 2003).
T1486	4535-4544	NNS	denotes	Mutations
T1487	4598-4603	VBP	denotes	block
T1488	4545-4547	IN	denotes	in
T1489	4548-4554	CC	denotes	either
T1490	4555-4559	NN	denotes	Gdf5
T1491	4560-4562	CC	denotes	or
T1492	4563-4566	DT	denotes	the
T1493	4588-4592	NN	denotes	gene
T1494	4567-4574	RB	denotes	closely
T1495	4575-4582	JJ	denotes	related
T1496	4583-4587	NN	denotes	Gdf6
T1497	4593-4597	RB	denotes	also
T1498	4604-4613	NN	denotes	formation
T1499	4614-4616	IN	denotes	of
T1500	4617-4623	NNS	denotes	joints
T1501	4624-4626	IN	denotes	at
T1502	4627-4635	JJ	denotes	specific
T1503	4636-4645	NNS	denotes	locations
T1504	4645-4647	,	denotes	,
T1505	4647-4656	VBG	denotes	providing
T1506	4657-4663	JJ	denotes	strong
T1507	4664-4672	NN	denotes	evidence
T1508	4673-4677	IN	denotes	that
T1509	4694-4697	VBP	denotes	are
T1510	4678-4683	DT	denotes	these
T1511	4684-4693	NNS	denotes	molecules
T1512	4698-4707	JJ	denotes	essential
T1513	4708-4711	IN	denotes	for
T1514	4712-4715	DT	denotes	the
T1515	4732-4739	NN	denotes	process
T1516	4716-4721	NN	denotes	joint
T1517	4722-4731	NN	denotes	formation
T1518	4740-4741	-LRB-	denotes	(
T1519	4741-4746	NNP	denotes	Storm
T1520	4747-4749	FW	denotes	et
T1521	4750-4753	FW	denotes	al.
T1522	4754-4758	CD	denotes	1994
T1523	4758-4759	:	denotes	;
T1524	4760-4766	NNP	denotes	Settle
T1525	4767-4769	FW	denotes	et
T1526	4770-4773	FW	denotes	al.
T1527	4774-4778	CD	denotes	2003
T1528	4778-4779	-RRB-	denotes	)
T1529	4779-4780	.	denotes	.
T1530	4780-4953	sentence	denotes	However, mutations in Bmp2 or Bmp4 cause early embryonic lethality, making it difficult to test their role in joint formation (Winnier et al. 1995; Zhang and Bradley 1996).
T1531	4781-4788	RB	denotes	However
T1532	4816-4821	VBP	denotes	cause
T1533	4788-4790	,	denotes	,
T1534	4790-4799	NNS	denotes	mutations
T1535	4800-4802	IN	denotes	in
T1536	4803-4807	NN	denotes	Bmp2
T1537	4808-4810	CC	denotes	or
T1538	4811-4815	NN	denotes	Bmp4
T1539	4822-4827	JJ	denotes	early
T1540	4838-4847	NN	denotes	lethality
T1541	4828-4837	JJ	denotes	embryonic
T1542	4847-4849	,	denotes	,
T1543	4849-4855	VBG	denotes	making
T1544	4856-4858	PRP	denotes	it
T1545	4859-4868	JJ	denotes	difficult
T1546	4869-4871	TO	denotes	to
T1547	4872-4876	VB	denotes	test
T1548	4877-4882	PRP$	denotes	their
T1549	4883-4887	NN	denotes	role
T1550	4888-4890	IN	denotes	in
T1551	4891-4896	NN	denotes	joint
T1552	4897-4906	NN	denotes	formation
T1553	4907-4908	-LRB-	denotes	(
T1554	4908-4915	NNP	denotes	Winnier
T1555	4916-4918	FW	denotes	et
T1556	4919-4922	FW	denotes	al.
T1557	4923-4927	CD	denotes	1995
T1558	4927-4928	:	denotes	;
T1559	4929-4934	NNP	denotes	Zhang
T1560	4935-4938	CC	denotes	and
T1561	4939-4946	NNP	denotes	Bradley
T1562	4947-4951	CD	denotes	1996
T1563	4951-4952	-RRB-	denotes	)
T1564	4952-4953	.	denotes	.
T1565	4953-5086	sentence	denotes	Much less is known about how signaling pathways function during the subsequent maturation and maintenance of adult joint structures.
T1566	4954-4958	RB	denotes	Much
T1567	4959-4963	JJR	denotes	less
T1568	4967-4972	VBN	denotes	known
T1569	4964-4966	VBZ	denotes	is
T1570	4973-4978	IN	denotes	about
T1571	4979-4982	WRB	denotes	how
T1572	5002-5010	VBP	denotes	function
T1573	4983-4992	NN	denotes	signaling
T1574	4993-5001	NNS	denotes	pathways
T1575	5011-5017	IN	denotes	during
T1576	5018-5021	DT	denotes	the
T1577	5033-5043	NN	denotes	maturation
T1578	5022-5032	JJ	denotes	subsequent
T1579	5044-5047	CC	denotes	and
T1580	5048-5059	NN	denotes	maintenance
T1581	5060-5062	IN	denotes	of
T1582	5063-5068	NN	denotes	adult
T1583	5075-5085	NNS	denotes	structures
T1584	5069-5074	NN	denotes	joint
T1585	5085-5086	.	denotes	.
T1586	5086-5379	sentence	denotes	Importantly, BMP signaling components are present in adult articular cartilage, suggesting that they may function during the late development or maintenance of this critical structure (Erlacher et al. 1998; Chubinskaya et al. 2000; Muehleman et al. 2002; Bau et al. 2002; Bobacz et al. 2003).
T1587	5087-5098	RB	denotes	Importantly
T1588	5125-5128	VBP	denotes	are
T1589	5098-5100	,	denotes	,
T1590	5100-5103	NN	denotes	BMP
T1591	5104-5113	NN	denotes	signaling
T1592	5114-5124	NNS	denotes	components
T1593	5129-5136	JJ	denotes	present
T1594	5137-5139	IN	denotes	in
T1595	5140-5145	NN	denotes	adult
T1596	5156-5165	NN	denotes	cartilage
T1597	5146-5155	JJ	denotes	articular
T1598	5165-5167	,	denotes	,
T1599	5167-5177	VBG	denotes	suggesting
T1600	5178-5182	IN	denotes	that
T1601	5192-5200	VB	denotes	function
T1602	5183-5187	PRP	denotes	they
T1603	5188-5191	MD	denotes	may
T1604	5201-5207	IN	denotes	during
T1605	5208-5211	DT	denotes	the
T1606	5217-5228	NN	denotes	development
T1607	5212-5216	JJ	denotes	late
T1608	5229-5231	CC	denotes	or
T1609	5232-5243	NN	denotes	maintenance
T1610	5244-5246	IN	denotes	of
T1611	5247-5251	DT	denotes	this
T1612	5261-5270	NN	denotes	structure
T1613	5252-5260	JJ	denotes	critical
T1614	5271-5272	-LRB-	denotes	(
T1615	5272-5280	NNP	denotes	Erlacher
T1616	5281-5283	FW	denotes	et
T1617	5284-5287	FW	denotes	al.
T1618	5288-5292	CD	denotes	1998
T1619	5292-5293	:	denotes	;
T1620	5294-5305	NNP	denotes	Chubinskaya
T1621	5306-5308	FW	denotes	et
T1622	5309-5312	FW	denotes	al.
T1623	5313-5317	CD	denotes	2000
T1624	5317-5318	:	denotes	;
T1625	5319-5328	NNP	denotes	Muehleman
T1626	5329-5331	FW	denotes	et
T1627	5332-5335	FW	denotes	al.
T1628	5336-5340	CD	denotes	2002
T1629	5340-5341	:	denotes	;
T1630	5342-5345	NNP	denotes	Bau
T1631	5346-5348	FW	denotes	et
T1632	5349-5352	FW	denotes	al.
T1633	5353-5357	CD	denotes	2002
T1634	5357-5358	:	denotes	;
T1635	5359-5365	NNP	denotes	Bobacz
T1636	5366-5368	FW	denotes	et
T1637	5369-5372	FW	denotes	al.
T1638	5373-5377	CD	denotes	2003
T1639	5377-5378	-RRB-	denotes	)
T1640	5378-5379	.	denotes	.
T1641	5379-5489	sentence	denotes	BMPs bind tetrameric complexes of two type I and two type II transmembrane serine-threonine kinase receptors.
T1642	5380-5384	NNS	denotes	BMPs
T1643	5385-5389	VBP	denotes	bind
T1644	5390-5400	JJ	denotes	tetrameric
T1645	5401-5410	NNS	denotes	complexes
T1646	5411-5413	IN	denotes	of
T1647	5414-5417	CD	denotes	two
T1648	5418-5422	NN	denotes	type
T1649	5423-5424	CD	denotes	I
T1650	5425-5428	CC	denotes	and
T1651	5429-5432	CD	denotes	two
T1652	5433-5437	NN	denotes	type
T1653	5479-5488	NNS	denotes	receptors
T1654	5438-5440	CD	denotes	II
T1655	5441-5454	JJ	denotes	transmembrane
T1656	5455-5461	NN	denotes	serine
T1657	5462-5471	NN	denotes	threonine
T1658	5461-5462	HYPH	denotes	-
T1659	5472-5478	NN	denotes	kinase
T1660	5488-5489	.	denotes	.
T1661	5489-5630	sentence	denotes	Upon BMP binding, these complexes transduce a signal by phosphorylating members of the Smad family of transcription factors (Massague 1996).
T1662	5490-5494	IN	denotes	Upon
T1663	5524-5533	VBP	denotes	transduce
T1664	5495-5498	NN	denotes	BMP
T1665	5499-5506	NN	denotes	binding
T1666	5506-5508	,	denotes	,
T1667	5508-5513	DT	denotes	these
T1668	5514-5523	NNS	denotes	complexes
T1669	5534-5535	DT	denotes	a
T1670	5536-5542	NN	denotes	signal
T1671	5543-5545	IN	denotes	by
T1672	5546-5561	VBG	denotes	phosphorylating
T1673	5562-5569	NNS	denotes	members
T1674	5570-5572	IN	denotes	of
T1675	5573-5576	DT	denotes	the
T1676	5582-5588	NN	denotes	family
T1677	5577-5581	NN	denotes	Smad
T1678	5589-5591	IN	denotes	of
T1679	5592-5605	NN	denotes	transcription
T1680	5606-5613	NNS	denotes	factors
T1681	5614-5615	-LRB-	denotes	(
T1682	5615-5623	NNP	denotes	Massague
T1683	5624-5628	CD	denotes	1996
T1684	5628-5629	-RRB-	denotes	)
T1685	5629-5630	.	denotes	.
T1686	5630-5743	sentence	denotes	Recent experiments have implicated two different BMP type I receptors in skeletal patterning, BMPR1A and BMPR1B.
T1687	5631-5637	JJ	denotes	Recent
T1688	5638-5649	NNS	denotes	experiments
T1689	5655-5665	VBN	denotes	implicated
T1690	5650-5654	VBP	denotes	have
T1691	5666-5669	CD	denotes	two
T1692	5691-5700	NNS	denotes	receptors
T1693	5670-5679	JJ	denotes	different
T1694	5680-5683	NN	denotes	BMP
T1695	5684-5688	NN	denotes	type
T1696	5689-5690	CD	denotes	I
T1697	5701-5703	IN	denotes	in
T1698	5704-5712	JJ	denotes	skeletal
T1699	5713-5723	NN	denotes	patterning
T1700	5723-5725	,	denotes	,
T1701	5725-5731	NN	denotes	BMPR1A
T1702	5732-5735	CC	denotes	and
T1703	5736-5742	NN	denotes	BMPR1B
T1704	5742-5743	.	denotes	.
T1705	5743-5944	sentence	denotes	Both receptors can bind BMP2, BMP4, and GDF5, although GDF5 shows higher affinity for BMPR1B (Koenig et al. 1994; ten Dijke et al. 1994; Yamaji et al. 1994; Nishitoh et al. 1996; Chalaux et al. 1998).
T1706	5744-5748	DT	denotes	Both
T1707	5749-5758	NNS	denotes	receptors
T1708	5763-5767	VB	denotes	bind
T1709	5759-5762	MD	denotes	can
T1710	5768-5772	NN	denotes	BMP2
T1711	5772-5774	,	denotes	,
T1712	5774-5778	NN	denotes	BMP4
T1713	5778-5780	,	denotes	,
T1714	5780-5783	CC	denotes	and
T1715	5784-5788	NN	denotes	GDF5
T1716	5788-5790	,	denotes	,
T1717	5790-5798	IN	denotes	although
T1718	5804-5809	VBZ	denotes	shows
T1719	5799-5803	NN	denotes	GDF5
T1720	5810-5816	JJR	denotes	higher
T1721	5817-5825	NN	denotes	affinity
T1722	5826-5829	IN	denotes	for
T1723	5830-5836	NN	denotes	BMPR1B
T1724	5837-5838	-LRB-	denotes	(
T1725	5838-5844	NNP	denotes	Koenig
T1726	5845-5847	FW	denotes	et
T1727	5848-5851	FW	denotes	al.
T1728	5852-5856	CD	denotes	1994
T1729	5856-5857	:	denotes	;
T1730	5858-5861	NNP	denotes	ten
T1731	5862-5867	NNP	denotes	Dijke
T1732	5868-5870	FW	denotes	et
T1733	5871-5874	FW	denotes	al.
T1734	5875-5879	CD	denotes	1994
T1735	5879-5880	:	denotes	;
T1736	5881-5887	NNP	denotes	Yamaji
T1737	5888-5890	FW	denotes	et
T1738	5891-5894	FW	denotes	al.
T1739	5895-5899	CD	denotes	1994
T1740	5899-5900	:	denotes	;
T1741	5901-5909	NNP	denotes	Nishitoh
T1742	5910-5912	FW	denotes	et
T1743	5913-5916	FW	denotes	al.
T1744	5917-5921	CD	denotes	1996
T1745	5921-5922	:	denotes	;
T1746	5923-5930	NNP	denotes	Chalaux
T1747	5931-5933	FW	denotes	et
T1748	5934-5937	FW	denotes	al.
T1749	5938-5942	CD	denotes	1998
T1750	5942-5943	-RRB-	denotes	)
T1751	5943-5944	.	denotes	.
T1752	5944-6025	sentence	denotes	Both receptors are also expressed in dynamic patterns during normal development.
T1753	5945-5949	DT	denotes	Both
T1754	5950-5959	NNS	denotes	receptors
T1755	5969-5978	VBN	denotes	expressed
T1756	5960-5963	VBP	denotes	are
T1757	5964-5968	RB	denotes	also
T1758	5979-5981	IN	denotes	in
T1759	5982-5989	JJ	denotes	dynamic
T1760	5990-5998	NNS	denotes	patterns
T1761	5999-6005	IN	denotes	during
T1762	6006-6012	JJ	denotes	normal
T1763	6013-6024	NN	denotes	development
T1764	6024-6025	.	denotes	.
T1765	6025-6194	sentence	denotes	In limbs, Bmpr1a expression becomes restricted to joint interzones, perichondrium, periarticular cartilage, hypertrophic chondrocytes, and interdigital limb mesenchyme.
T1766	6026-6028	IN	denotes	In
T1767	6054-6061	VBZ	denotes	becomes
T1768	6029-6034	NNS	denotes	limbs
T1769	6034-6036	,	denotes	,
T1770	6036-6042	NN	denotes	Bmpr1a
T1771	6043-6053	NN	denotes	expression
T1772	6062-6072	JJ	denotes	restricted
T1773	6073-6075	IN	denotes	to
T1774	6076-6081	NN	denotes	joint
T1775	6082-6092	NNS	denotes	interzones
T1776	6092-6094	,	denotes	,
T1777	6094-6107	NN	denotes	perichondrium
T1778	6107-6109	,	denotes	,
T1779	6109-6122	JJ	denotes	periarticular
T1780	6123-6132	NN	denotes	cartilage
T1781	6132-6134	,	denotes	,
T1782	6134-6146	JJ	denotes	hypertrophic
T1783	6147-6159	NNS	denotes	chondrocytes
T1784	6159-6161	,	denotes	,
T1785	6161-6164	CC	denotes	and
T1786	6165-6177	JJ	denotes	interdigital
T1787	6183-6193	NN	denotes	mesenchyme
T1788	6178-6182	NN	denotes	limb
T1789	6193-6194	.	denotes	.
T1790	6194-6451	sentence	denotes	In comparison, Bmpr1b expression is seen primarily in condensing precartilaginous mesenchymal cells, regions flanking joint interzones, perichondrium, and periarticular cartilage (Dewulf et al. 1995; Mishina et al. 1995; Zou et al. 1997; Baur et al. 2000).
T1791	6195-6197	IN	denotes	In
T1792	6231-6235	VBN	denotes	seen
T1793	6198-6208	NN	denotes	comparison
T1794	6208-6210	,	denotes	,
T1795	6210-6216	NN	denotes	Bmpr1b
T1796	6217-6227	NN	denotes	expression
T1797	6228-6230	VBZ	denotes	is
T1798	6236-6245	RB	denotes	primarily
T1799	6246-6248	IN	denotes	in
T1800	6249-6259	VBG	denotes	condensing
T1801	6289-6294	NNS	denotes	cells
T1802	6260-6276	JJ	denotes	precartilaginous
T1803	6277-6288	JJ	denotes	mesenchymal
T1804	6294-6296	,	denotes	,
T1805	6296-6303	NNS	denotes	regions
T1806	6304-6312	VBG	denotes	flanking
T1807	6313-6318	NN	denotes	joint
T1808	6319-6329	NNS	denotes	interzones
T1809	6329-6331	,	denotes	,
T1810	6331-6344	NN	denotes	perichondrium
T1811	6344-6346	,	denotes	,
T1812	6346-6349	CC	denotes	and
T1813	6350-6363	JJ	denotes	periarticular
T1814	6364-6373	NN	denotes	cartilage
T1815	6374-6375	-LRB-	denotes	(
T1816	6375-6381	NNP	denotes	Dewulf
T1817	6382-6384	FW	denotes	et
T1818	6385-6388	FW	denotes	al.
T1819	6389-6393	CD	denotes	1995
T1820	6393-6394	:	denotes	;
T1821	6395-6402	NNP	denotes	Mishina
T1822	6403-6405	FW	denotes	et
T1823	6406-6409	FW	denotes	al.
T1824	6410-6414	CD	denotes	1995
T1825	6414-6415	:	denotes	;
T1826	6416-6419	NNP	denotes	Zou
T1827	6420-6422	FW	denotes	et
T1828	6423-6426	FW	denotes	al.
T1829	6427-6431	CD	denotes	1997
T1830	6431-6432	:	denotes	;
T1831	6433-6437	NNP	denotes	Baur
T1832	6438-6440	FW	denotes	et
T1833	6441-6444	FW	denotes	al.
T1834	6445-6449	CD	denotes	2000
T1835	6449-6450	-RRB-	denotes	)
T1836	6450-6451	.	denotes	.
T1837	6451-6661	sentence	denotes	Null mutations in the Bmpr1b gene produce viable mice with defects in bone and joint formation that closely resemble those seen in mice missing Gdf5 (Storm and Kingsley 1996; Baur et al. 2000; Yi et al. 2000).
T1838	6452-6456	JJ	denotes	Null
T1839	6457-6466	NNS	denotes	mutations
T1840	6486-6493	VBP	denotes	produce
T1841	6467-6469	IN	denotes	in
T1842	6470-6473	DT	denotes	the
T1843	6481-6485	NN	denotes	gene
T1844	6474-6480	NN	denotes	Bmpr1b
T1845	6494-6500	JJ	denotes	viable
T1846	6501-6505	NNS	denotes	mice
T1847	6506-6510	IN	denotes	with
T1848	6511-6518	NNS	denotes	defects
T1849	6519-6521	IN	denotes	in
T1850	6522-6526	NN	denotes	bone
T1851	6537-6546	NN	denotes	formation
T1852	6527-6530	CC	denotes	and
T1853	6531-6536	NN	denotes	joint
T1854	6547-6551	WDT	denotes	that
T1855	6560-6568	VBP	denotes	resemble
T1856	6552-6559	RB	denotes	closely
T1857	6569-6574	DT	denotes	those
T1858	6575-6579	VBN	denotes	seen
T1859	6580-6582	IN	denotes	in
T1860	6583-6587	NNS	denotes	mice
T1861	6588-6595	VBG	denotes	missing
T1862	6596-6600	NN	denotes	Gdf5
T1863	6601-6602	-LRB-	denotes	(
T1864	6602-6607	NNP	denotes	Storm
T1865	6608-6611	CC	denotes	and
T1866	6612-6620	NNP	denotes	Kingsley
T1867	6621-6625	CD	denotes	1996
T1868	6625-6626	:	denotes	;
T1869	6627-6631	NNP	denotes	Baur
T1870	6632-6634	FW	denotes	et
T1871	6635-6638	FW	denotes	al.
T1872	6639-6643	CD	denotes	2000
T1873	6643-6644	:	denotes	;
T1874	6645-6647	NNP	denotes	Yi
T1875	6648-6650	FW	denotes	et
T1876	6651-6654	FW	denotes	al.
T1877	6655-6659	CD	denotes	2000
T1878	6659-6660	-RRB-	denotes	)
T1879	6660-6661	.	denotes	.
T1880	6661-6845	sentence	denotes	Null mutations in Bmpr1a cause early embryonic lethality, with defects in gastrulation similar to those seen in mice with mutations in Bmp4 (Mishina et al. 1995; Winnier et al. 1995).
T1881	6662-6666	JJ	denotes	Null
T1882	6667-6676	NNS	denotes	mutations
T1883	6687-6692	VBP	denotes	cause
T1884	6677-6679	IN	denotes	in
T1885	6680-6686	NN	denotes	Bmpr1a
T1886	6693-6698	JJ	denotes	early
T1887	6709-6718	NN	denotes	lethality
T1888	6699-6708	JJ	denotes	embryonic
T1889	6718-6720	,	denotes	,
T1890	6720-6724	IN	denotes	with
T1891	6749-6756	JJ	denotes	similar
T1892	6725-6732	NNS	denotes	defects
T1893	6733-6735	IN	denotes	in
T1894	6736-6748	NN	denotes	gastrulation
T1895	6757-6759	IN	denotes	to
T1896	6760-6765	DT	denotes	those
T1897	6766-6770	VBN	denotes	seen
T1898	6771-6773	IN	denotes	in
T1899	6774-6778	NNS	denotes	mice
T1900	6779-6783	IN	denotes	with
T1901	6784-6793	NNS	denotes	mutations
T1902	6794-6796	IN	denotes	in
T1903	6797-6801	NN	denotes	Bmp4
T1904	6802-6803	-LRB-	denotes	(
T1905	6803-6810	NNP	denotes	Mishina
T1906	6811-6813	FW	denotes	et
T1907	6814-6817	FW	denotes	al.
T1908	6818-6822	CD	denotes	1995
T1909	6822-6823	:	denotes	;
T1910	6824-6831	NNP	denotes	Winnier
T1911	6832-6834	FW	denotes	et
T1912	6835-6838	FW	denotes	al.
T1913	6839-6843	CD	denotes	1995
T1914	6843-6844	-RRB-	denotes	)
T1915	6844-6845	.	denotes	.
T1916	6845-7037	sentence	denotes	Recent studies with floxed alleles suggest that Bmpr1a is also required for many later developmental events, but its roles in bone and joint formation have not yet been tested (Mishina 2003).
T1917	6846-6852	JJ	denotes	Recent
T1918	6853-6860	NNS	denotes	studies
T1919	6881-6888	VBP	denotes	suggest
T1920	6861-6865	IN	denotes	with
T1921	6866-6872	VBN	denotes	floxed
T1922	6873-6880	NNS	denotes	alleles
T1923	6889-6893	IN	denotes	that
T1924	6909-6917	VBN	denotes	required
T1925	6894-6900	NN	denotes	Bmpr1a
T1926	6901-6903	VBZ	denotes	is
T1927	6904-6908	RB	denotes	also
T1928	6918-6921	IN	denotes	for
T1929	6922-6926	JJ	denotes	many
T1930	6947-6953	NNS	denotes	events
T1931	6927-6932	JJ	denotes	later
T1932	6933-6946	JJ	denotes	developmental
T1933	6953-6955	,	denotes	,
T1934	6955-6958	CC	denotes	but
T1935	6959-6962	PRP$	denotes	its
T1936	6963-6968	NNS	denotes	roles
T1937	7015-7021	VBN	denotes	tested
T1938	6969-6971	IN	denotes	in
T1939	6972-6976	NN	denotes	bone
T1940	6987-6996	NN	denotes	formation
T1941	6977-6980	CC	denotes	and
T1942	6981-6986	NN	denotes	joint
T1943	6997-7001	VBP	denotes	have
T1944	7002-7005	RB	denotes	not
T1945	7006-7009	RB	denotes	yet
T1946	7010-7014	VBN	denotes	been
T1947	7022-7023	-LRB-	denotes	(
T1948	7023-7030	NNP	denotes	Mishina
T1949	7031-7035	CD	denotes	2003
T1950	7035-7036	-RRB-	denotes	)
T1951	7036-7037	.	denotes	.
T1952	7037-7206	sentence	denotes	A genetic system for activating or inactivating genes specifically in joint tissues would be particularly useful for further studies of joint formation and maintenance.
T1953	7038-7039	DT	denotes	A
T1954	7048-7054	NN	denotes	system
T1955	7040-7047	JJ	denotes	genetic
T1956	7128-7130	VB	denotes	be
T1957	7055-7058	IN	denotes	for
T1958	7059-7069	VBG	denotes	activating
T1959	7070-7072	CC	denotes	or
T1960	7073-7085	VBG	denotes	inactivating
T1961	7086-7091	NNS	denotes	genes
T1962	7092-7104	RB	denotes	specifically
T1963	7105-7107	IN	denotes	in
T1964	7108-7113	NN	denotes	joint
T1965	7114-7121	NNS	denotes	tissues
T1966	7122-7127	MD	denotes	would
T1967	7131-7143	RB	denotes	particularly
T1968	7144-7150	JJ	denotes	useful
T1969	7151-7154	IN	denotes	for
T1970	7155-7162	JJ	denotes	further
T1971	7163-7170	NNS	denotes	studies
T1972	7171-7173	IN	denotes	of
T1973	7174-7179	NN	denotes	joint
T1974	7180-7189	NN	denotes	formation
T1975	7190-7193	CC	denotes	and
T1976	7194-7205	NN	denotes	maintenance
T1977	7205-7206	.	denotes	.
T1978	7206-7408	sentence	denotes	Here we take advantage of the tissue-specific expression pattern of the Gdf5 gene to engineer a Cre/loxP system (Nagy 2000), Gdf5-Cre, that can be used to remove or ectopically express genes in joints.
T1979	7207-7211	RB	denotes	Here
T1980	7215-7219	VBP	denotes	take
T1981	7212-7214	PRP	denotes	we
T1982	7220-7229	NN	denotes	advantage
T1983	7230-7232	IN	denotes	of
T1984	7233-7236	DT	denotes	the
T1985	7264-7271	NN	denotes	pattern
T1986	7237-7243	NN	denotes	tissue
T1987	7244-7252	JJ	denotes	specific
T1988	7243-7244	HYPH	denotes	-
T1989	7253-7263	NN	denotes	expression
T1990	7272-7274	IN	denotes	of
T1991	7275-7278	DT	denotes	the
T1992	7284-7288	NN	denotes	gene
T1993	7279-7283	NN	denotes	Gdf5
T1994	7289-7291	TO	denotes	to
T1995	7292-7300	VB	denotes	engineer
T1996	7301-7302	DT	denotes	a
T1997	7312-7318	NN	denotes	system
T1998	7303-7306	NN	denotes	Cre
T1999	7307-7311	NN	denotes	loxP
T2000	7306-7307	HYPH	denotes	/
T2001	7319-7320	-LRB-	denotes	(
T2002	7320-7324	NNP	denotes	Nagy
T2003	7325-7329	CD	denotes	2000
T2004	7329-7330	-RRB-	denotes	)
T2005	7330-7332	,	denotes	,
T2006	7332-7336	NN	denotes	Gdf5
T2007	7337-7340	NN	denotes	Cre
T2008	7336-7337	HYPH	denotes	-
T2009	7340-7342	,	denotes	,
T2010	7342-7346	WDT	denotes	that
T2011	7354-7358	VBN	denotes	used
T2012	7347-7350	MD	denotes	can
T2013	7351-7353	VB	denotes	be
T2014	7359-7361	TO	denotes	to
T2015	7362-7368	VB	denotes	remove
T2016	7369-7371	CC	denotes	or
T2017	7372-7383	RB	denotes	ectopically
T2018	7384-7391	VB	denotes	express
T2019	7392-7397	NNS	denotes	genes
T2020	7398-7400	IN	denotes	in
T2021	7401-7407	NNS	denotes	joints
T2022	7407-7408	.	denotes	.
T2023	7408-7638	sentence	denotes	Tests with reporter mice show that this system is capable of modifying genes in all of the structures of the mature synovial joint, including the ligaments of the joint capsule, the synovial membrane, and the articular cartilage.
T2024	7409-7414	NNS	denotes	Tests
T2025	7434-7438	VBP	denotes	show
T2026	7415-7419	IN	denotes	with
T2027	7420-7428	NN	denotes	reporter
T2028	7429-7433	NNS	denotes	mice
T2029	7439-7443	IN	denotes	that
T2030	7456-7458	VBZ	denotes	is
T2031	7444-7448	DT	denotes	this
T2032	7449-7455	NN	denotes	system
T2033	7459-7466	JJ	denotes	capable
T2034	7467-7469	IN	denotes	of
T2035	7470-7479	VBG	denotes	modifying
T2036	7480-7485	NNS	denotes	genes
T2037	7486-7488	IN	denotes	in
T2038	7489-7492	DT	denotes	all
T2039	7493-7495	IN	denotes	of
T2040	7496-7499	DT	denotes	the
T2041	7500-7510	NNS	denotes	structures
T2042	7511-7513	IN	denotes	of
T2043	7514-7517	DT	denotes	the
T2044	7534-7539	NN	denotes	joint
T2045	7518-7524	JJ	denotes	mature
T2046	7525-7533	JJ	denotes	synovial
T2047	7539-7541	,	denotes	,
T2048	7541-7550	VBG	denotes	including
T2049	7551-7554	DT	denotes	the
T2050	7555-7564	NNS	denotes	ligaments
T2051	7565-7567	IN	denotes	of
T2052	7568-7571	DT	denotes	the
T2053	7578-7585	NN	denotes	capsule
T2054	7572-7577	NN	denotes	joint
T2055	7585-7587	,	denotes	,
T2056	7587-7590	DT	denotes	the
T2057	7600-7608	NN	denotes	membrane
T2058	7591-7599	JJ	denotes	synovial
T2059	7608-7610	,	denotes	,
T2060	7610-7613	CC	denotes	and
T2061	7614-7617	DT	denotes	the
T2062	7628-7637	NN	denotes	cartilage
T2063	7618-7627	JJ	denotes	articular
T2064	7637-7638	.	denotes	.
T2065	7638-7885	sentence	denotes	Gdf5-Cre recombination bypasses the early embryonic lethality of null mutations in Bmpr1a, and shows that this receptor is required for early joint formation at some locations and for initiation of programmed cell death in webbing between digits.
T2066	7639-7643	NN	denotes	Gdf5
T2067	7644-7647	NN	denotes	Cre
T2068	7643-7644	HYPH	denotes	-
T2069	7648-7661	NN	denotes	recombination
T2070	7662-7670	VBZ	denotes	bypasses
T2071	7671-7674	DT	denotes	the
T2072	7691-7700	NN	denotes	lethality
T2073	7675-7680	JJ	denotes	early
T2074	7681-7690	JJ	denotes	embryonic
T2075	7701-7703	IN	denotes	of
T2076	7704-7708	JJ	denotes	null
T2077	7709-7718	NNS	denotes	mutations
T2078	7719-7721	IN	denotes	in
T2079	7722-7728	NN	denotes	Bmpr1a
T2080	7728-7730	,	denotes	,
T2081	7730-7733	CC	denotes	and
T2082	7734-7739	VBZ	denotes	shows
T2083	7740-7744	IN	denotes	that
T2084	7762-7770	VBN	denotes	required
T2085	7745-7749	DT	denotes	this
T2086	7750-7758	NN	denotes	receptor
T2087	7759-7761	VBZ	denotes	is
T2088	7771-7774	IN	denotes	for
T2089	7775-7780	JJ	denotes	early
T2090	7787-7796	NN	denotes	formation
T2091	7781-7786	NN	denotes	joint
T2092	7797-7799	IN	denotes	at
T2093	7800-7804	DT	denotes	some
T2094	7805-7814	NNS	denotes	locations
T2095	7815-7818	CC	denotes	and
T2096	7819-7822	IN	denotes	for
T2097	7823-7833	NN	denotes	initiation
T2098	7834-7836	IN	denotes	of
T2099	7837-7847	VBN	denotes	programmed
T2100	7853-7858	NN	denotes	death
T2101	7848-7852	NN	denotes	cell
T2102	7859-7861	IN	denotes	in
T2103	7862-7869	VBG	denotes	webbing
T2104	7870-7877	IN	denotes	between
T2105	7878-7884	NNS	denotes	digits
T2106	7884-7885	.	denotes	.
T2107	7885-8006	sentence	denotes	Interestingly, Bmpr1a is also required for postnatal maintenance of articular cartilage throughout most of the skeleton.
T2108	7886-7899	RB	denotes	Interestingly
T2109	7908-7910	VBZ	denotes	is
T2110	7899-7901	,	denotes	,
T2111	7901-7907	NN	denotes	Bmpr1a
T2112	7911-7915	RB	denotes	also
T2113	7916-7924	VBN	denotes	required
T2114	7925-7928	IN	denotes	for
T2115	7929-7938	JJ	denotes	postnatal
T2116	7939-7950	NN	denotes	maintenance
T2117	7951-7953	IN	denotes	of
T2118	7954-7963	JJ	denotes	articular
T2119	7964-7973	NN	denotes	cartilage
T2120	7974-7984	IN	denotes	throughout
T2121	7985-7989	JJS	denotes	most
T2122	7990-7992	IN	denotes	of
T2123	7993-7996	DT	denotes	the
T2124	7997-8005	NN	denotes	skeleton
T2125	8005-8006	.	denotes	.
T2126	8006-8162	sentence	denotes	In Gdf5-Cre/Bmpr1afloxP mice, articular cartilage initially forms normally, but subsequently loses expression of several key cartilage markers after birth.
T2127	8007-8009	IN	denotes	In
T2128	8067-8072	VBZ	denotes	forms
T2129	8010-8014	NN	denotes	Gdf5
T2130	8015-8018	NN	denotes	Cre
T2131	8014-8015	HYPH	denotes	-
T2132	8031-8035	NNS	denotes	mice
T2133	8018-8019	HYPH	denotes	/
T2134	8019-8030	NN	denotes	Bmpr1afloxP
T2135	8035-8037	,	denotes	,
T2136	8037-8046	JJ	denotes	articular
T2137	8047-8056	NN	denotes	cartilage
T2138	8057-8066	RB	denotes	initially
T2139	8073-8081	RB	denotes	normally
T2140	8081-8083	,	denotes	,
T2141	8083-8086	CC	denotes	but
T2142	8087-8099	RB	denotes	subsequently
T2143	8100-8105	VBZ	denotes	loses
T2144	8106-8116	NN	denotes	expression
T2145	8117-8119	IN	denotes	of
T2146	8120-8127	JJ	denotes	several
T2147	8142-8149	NNS	denotes	markers
T2148	8128-8131	JJ	denotes	key
T2149	8132-8141	NN	denotes	cartilage
T2150	8150-8155	IN	denotes	after
T2151	8156-8161	NN	denotes	birth
T2152	8161-8162	.	denotes	.
T2153	8162-8262	sentence	denotes	It ultimately fibrillates and degenerates, resulting in severe osteoarthritis and loss of mobility.
T2154	8163-8165	PRP	denotes	It
T2155	8177-8188	VBZ	denotes	fibrillates
T2156	8166-8176	RB	denotes	ultimately
T2157	8189-8192	CC	denotes	and
T2158	8193-8204	VBZ	denotes	degenerates
T2159	8204-8206	,	denotes	,
T2160	8206-8215	VBG	denotes	resulting
T2161	8216-8218	IN	denotes	in
T2162	8219-8225	JJ	denotes	severe
T2163	8226-8240	NN	denotes	osteoarthritis
T2164	8241-8244	CC	denotes	and
T2165	8245-8249	NN	denotes	loss
T2166	8250-8252	IN	denotes	of
T2167	8253-8261	NN	denotes	mobility
T2168	8261-8262	.	denotes	.
T2169	8262-8470	sentence	denotes	These experiments suggest that BMP signaling is required for normal maintenance of postnatal articular cartilage, and that modulation of the BMP signaling pathway may play an important role in joint disease.
T2170	8263-8268	DT	denotes	These
T2171	8269-8280	NNS	denotes	experiments
T2172	8281-8288	VBP	denotes	suggest
T2173	8289-8293	IN	denotes	that
T2174	8311-8319	VBN	denotes	required
T2175	8294-8297	NN	denotes	BMP
T2176	8298-8307	NN	denotes	signaling
T2177	8308-8310	VBZ	denotes	is
T2178	8320-8323	IN	denotes	for
T2179	8324-8330	JJ	denotes	normal
T2180	8331-8342	NN	denotes	maintenance
T2181	8343-8345	IN	denotes	of
T2182	8346-8355	JJ	denotes	postnatal
T2183	8366-8375	NN	denotes	cartilage
T2184	8356-8365	JJ	denotes	articular
T2185	8375-8377	,	denotes	,
T2186	8377-8380	CC	denotes	and
T2187	8381-8385	IN	denotes	that
T2188	8430-8434	VB	denotes	play
T2189	8386-8396	NN	denotes	modulation
T2190	8397-8399	IN	denotes	of
T2191	8400-8403	DT	denotes	the
T2192	8418-8425	NN	denotes	pathway
T2193	8404-8407	NN	denotes	BMP
T2194	8408-8417	NN	denotes	signaling
T2195	8426-8429	MD	denotes	may
T2196	8435-8437	DT	denotes	an
T2197	8448-8452	NN	denotes	role
T2198	8438-8447	JJ	denotes	important
T2199	8453-8455	IN	denotes	in
T2200	8456-8461	NN	denotes	joint
T2201	8462-8469	NN	denotes	disease
T2202	8469-8470	.	denotes	.
T9672	42908-42915	VBN	denotes	delayed
T9673	42849-42862	NN	denotes	recombination
T2682	8481-8488	JJ	denotes	Genetic
T2683	8489-8495	NN	denotes	System
T2684	8496-8499	IN	denotes	for
T2685	8500-8507	VBG	denotes	Testing
T2686	8508-8511	DT	denotes	the
T2687	8512-8520	NN	denotes	Function
T2688	8521-8523	IN	denotes	of
T2689	8524-8529	NNS	denotes	Genes
T2690	8530-8532	IN	denotes	in
T2691	8533-8538	NN	denotes	Joint
T2692	8539-8550	NN	denotes	Development
T2693	8550-8752	sentence	denotes	To generate a general system capable of specifically testing genes for functions in skeletal joint development, we engineered transgenic mice to express Cre recombinase in developing joints (Figure 1).
T2694	8551-8553	TO	denotes	To
T2695	8554-8562	VB	denotes	generate
T2696	8666-8676	VBD	denotes	engineered
T2697	8563-8564	DT	denotes	a
T2698	8573-8579	NN	denotes	system
T2699	8565-8572	JJ	denotes	general
T2700	8580-8587	JJ	denotes	capable
T2701	8588-8590	IN	denotes	of
T2702	8591-8603	RB	denotes	specifically
T2703	8604-8611	VBG	denotes	testing
T2704	8612-8617	NNS	denotes	genes
T2705	8618-8621	IN	denotes	for
T2706	8622-8631	NNS	denotes	functions
T2707	8632-8634	IN	denotes	in
T2708	8635-8643	JJ	denotes	skeletal
T2709	8650-8661	NN	denotes	development
T2710	8644-8649	NN	denotes	joint
T2711	8661-8663	,	denotes	,
T2712	8663-8665	PRP	denotes	we
T2713	8677-8687	JJ	denotes	transgenic
T2714	8688-8692	NNS	denotes	mice
T2715	8693-8695	TO	denotes	to
T2716	8696-8703	VB	denotes	express
T2717	8704-8707	NN	denotes	Cre
T2718	8708-8719	NN	denotes	recombinase
T2719	8720-8722	IN	denotes	in
T2720	8723-8733	VBG	denotes	developing
T2721	8734-8740	NNS	denotes	joints
T2722	8741-8742	-LRB-	denotes	(
T2723	8742-8748	NN	denotes	Figure
T2724	8749-8750	CD	denotes	1
T2725	8750-8751	-RRB-	denotes	)
T2726	8751-8752	.	denotes	.
T2727	8752-8867	sentence	denotes	Gdf5 is a gene strongly expressed in stripes across developing skeletal elements during embryonic joint formation.
T2728	8753-8757	NN	denotes	Gdf5
T2729	8758-8760	VBZ	denotes	is
T2730	8761-8762	DT	denotes	a
T2731	8763-8767	NN	denotes	gene
T2732	8768-8776	RB	denotes	strongly
T2733	8777-8786	VBN	denotes	expressed
T2734	8787-8789	IN	denotes	in
T2735	8790-8797	NNS	denotes	stripes
T2736	8798-8804	IN	denotes	across
T2737	8805-8815	VBG	denotes	developing
T2738	8825-8833	NNS	denotes	elements
T2739	8816-8824	JJ	denotes	skeletal
T2740	8834-8840	IN	denotes	during
T2741	8841-8850	JJ	denotes	embryonic
T2742	8857-8866	NN	denotes	formation
T2743	8851-8856	NN	denotes	joint
T2744	8866-8867	.	denotes	.
T2745	8867-9154	sentence	denotes	A bacterial artificial chromosome (BAC) containing the Gdf5 locus was modified by homologous recombination in bacteria to insert a cassette encoding Cre-internal ribosome entry site (IRES)-human placental alkaline phosphatase (hPLAP) into the translation start site of Gdf5 (Figure 1A).
T2746	8868-8869	DT	denotes	A
T2747	8891-8901	NN	denotes	chromosome
T2748	8870-8879	JJ	denotes	bacterial
T2749	8880-8890	JJ	denotes	artificial
T2750	8938-8946	VBN	denotes	modified
T2751	8902-8903	-LRB-	denotes	(
T2752	8903-8906	NN	denotes	BAC
T2753	8906-8907	-RRB-	denotes	)
T2754	8908-8918	VBG	denotes	containing
T2755	8919-8922	DT	denotes	the
T2756	8928-8933	NN	denotes	locus
T2757	8923-8927	NN	denotes	Gdf5
T2758	8934-8937	VBD	denotes	was
T2759	8947-8949	IN	denotes	by
T2760	8950-8960	JJ	denotes	homologous
T2761	8961-8974	NN	denotes	recombination
T2762	8975-8977	IN	denotes	in
T2763	8978-8986	NNS	denotes	bacteria
T2764	8987-8989	TO	denotes	to
T2765	8990-8996	VB	denotes	insert
T2766	8997-8998	DT	denotes	a
T2767	8999-9007	NN	denotes	cassette
T2768	9008-9016	VBG	denotes	encoding
T2769	9017-9020	NN	denotes	Cre
T2770	9082-9093	NN	denotes	phosphatase
T2771	9020-9021	HYPH	denotes	-
T2772	9021-9029	JJ	denotes	internal
T2773	9039-9044	NN	denotes	entry
T2774	9030-9038	NN	denotes	ribosome
T2775	9045-9049	NN	denotes	site
T2776	9050-9051	-LRB-	denotes	(
T2777	9051-9055	NN	denotes	IRES
T2778	9055-9056	-RRB-	denotes	)
T2779	9056-9057	HYPH	denotes	-
T2780	9057-9062	JJ	denotes	human
T2781	9063-9072	JJ	denotes	placental
T2782	9073-9081	NN	denotes	alkaline
T2783	9094-9095	-LRB-	denotes	(
T2784	9095-9100	NN	denotes	hPLAP
T2785	9100-9101	-RRB-	denotes	)
T2786	9102-9106	IN	denotes	into
T2787	9107-9110	DT	denotes	the
T2788	9129-9133	NN	denotes	site
T2789	9111-9122	NN	denotes	translation
T2790	9123-9128	NN	denotes	start
T2791	9134-9136	IN	denotes	of
T2792	9137-9141	NN	denotes	Gdf5
T2793	9142-9143	-LRB-	denotes	(
T2794	9143-9149	NN	denotes	Figure
T2795	9150-9152	CD	denotes	1A
T2796	9152-9153	-RRB-	denotes	)
T2797	9153-9154	.	denotes	.
T2798	9154-9220	sentence	denotes	This modified BAC was then used to make lines of transgenic mice.
T2799	9155-9159	DT	denotes	This
T2800	9169-9172	NN	denotes	BAC
T2801	9160-9168	VBN	denotes	modified
T2802	9182-9186	VBN	denotes	used
T2803	9173-9176	VBD	denotes	was
T2804	9177-9181	RB	denotes	then
T2805	9187-9189	TO	denotes	to
T2806	9190-9194	VB	denotes	make
T2807	9195-9200	NNS	denotes	lines
T2808	9201-9203	IN	denotes	of
T2809	9204-9214	JJ	denotes	transgenic
T2810	9215-9219	NNS	denotes	mice
T2811	9219-9220	.	denotes	.
T2812	9220-9478	sentence	denotes	The resulting Gdf5-Cre transgenic mice were tested for transgene expression and Cre recombinase activity by crossing them to R26R reporter mice that activate the expression of lacZ after Cre-mediated removal of transcriptional stop sequences (Soriano 1999).
T2813	9221-9224	DT	denotes	The
T2814	9255-9259	NNS	denotes	mice
T2815	9225-9234	VBG	denotes	resulting
T2816	9235-9239	NN	denotes	Gdf5
T2817	9240-9243	NN	denotes	Cre
T2818	9239-9240	HYPH	denotes	-
T2819	9244-9254	JJ	denotes	transgenic
T2820	9265-9271	VBN	denotes	tested
T2821	9260-9264	VBD	denotes	were
T2822	9272-9275	IN	denotes	for
T2823	9276-9285	NN	denotes	transgene
T2824	9286-9296	NN	denotes	expression
T2825	9297-9300	CC	denotes	and
T2826	9301-9304	NN	denotes	Cre
T2827	9305-9316	NN	denotes	recombinase
T2828	9317-9325	NN	denotes	activity
T2829	9326-9328	IN	denotes	by
T2830	9329-9337	VBG	denotes	crossing
T2831	9338-9342	PRP	denotes	them
T2832	9343-9345	IN	denotes	to
T2833	9346-9350	NN	denotes	R26R
T2834	9351-9359	NN	denotes	reporter
T2835	9360-9364	NNS	denotes	mice
T2836	9365-9369	WDT	denotes	that
T2837	9370-9378	VBP	denotes	activate
T2838	9379-9382	DT	denotes	the
T2839	9383-9393	NN	denotes	expression
T2840	9394-9396	IN	denotes	of
T2841	9397-9401	NN	denotes	lacZ
T2842	9402-9407	IN	denotes	after
T2843	9408-9411	NN	denotes	Cre
T2844	9412-9420	VBN	denotes	mediated
T2845	9411-9412	HYPH	denotes	-
T2846	9421-9428	NN	denotes	removal
T2847	9429-9431	IN	denotes	of
T2848	9432-9447	JJ	denotes	transcriptional
T2849	9453-9462	NNS	denotes	sequences
T2850	9448-9452	NN	denotes	stop
T2851	9463-9464	-LRB-	denotes	(
T2852	9464-9471	NNP	denotes	Soriano
T2853	9472-9476	CD	denotes	1999
T2854	9476-9477	-RRB-	denotes	)
T2855	9477-9478	.	denotes	.
T2856	9478-9634	sentence	denotes	The resulting progeny were analyzed both for expression of the transgene by assaying HPLAP activity and for recombination of DNA by assaying LACZ activity.
T2857	9479-9482	DT	denotes	The
T2858	9493-9500	NN	denotes	progeny
T2859	9483-9492	VBG	denotes	resulting
T2860	9506-9514	VBN	denotes	analyzed
T2861	9501-9505	VBD	denotes	were
T2862	9515-9519	CC	denotes	both
T2863	9520-9523	IN	denotes	for
T2864	9524-9534	NN	denotes	expression
T2865	9535-9537	IN	denotes	of
T2866	9538-9541	DT	denotes	the
T2867	9542-9551	NN	denotes	transgene
T2868	9552-9554	IN	denotes	by
T2869	9555-9563	VBG	denotes	assaying
T2870	9564-9569	NN	denotes	HPLAP
T2871	9570-9578	NN	denotes	activity
T2872	9579-9582	CC	denotes	and
T2873	9583-9586	IN	denotes	for
T2874	9587-9600	NN	denotes	recombination
T2875	9601-9603	IN	denotes	of
T2876	9604-9607	NN	denotes	DNA
T2877	9608-9610	IN	denotes	by
T2878	9611-9619	VBG	denotes	assaying
T2879	9620-9624	NN	denotes	LACZ
T2880	9625-9633	NN	denotes	activity
T2881	9633-9634	.	denotes	.
T2882	9634-9798	sentence	denotes	The progeny from all three lines showed strong LACZ expression primarily in joints, and in two of three lines HPLAP expression could also be seen in joint regions.
T2883	9635-9638	DT	denotes	The
T2884	9639-9646	NN	denotes	progeny
T2885	9668-9674	VBD	denotes	showed
T2886	9647-9651	IN	denotes	from
T2887	9652-9655	DT	denotes	all
T2888	9662-9667	NNS	denotes	lines
T2889	9656-9661	CD	denotes	three
T2890	9675-9681	JJ	denotes	strong
T2891	9687-9697	NN	denotes	expression
T2892	9682-9686	NN	denotes	LACZ
T2893	9698-9707	RB	denotes	primarily
T2894	9708-9710	IN	denotes	in
T2895	9711-9717	NNS	denotes	joints
T2896	9717-9719	,	denotes	,
T2897	9719-9722	CC	denotes	and
T2898	9723-9725	IN	denotes	in
T2899	9776-9780	VBN	denotes	seen
T2900	9726-9729	CD	denotes	two
T2901	9733-9738	CD	denotes	three
T2902	9730-9732	IN	denotes	of
T2903	9739-9744	NNS	denotes	lines
T2904	9745-9750	NN	denotes	HPLAP
T2905	9751-9761	NN	denotes	expression
T2906	9762-9767	MD	denotes	could
T2907	9768-9772	RB	denotes	also
T2908	9773-9775	VB	denotes	be
T2909	9781-9783	IN	denotes	in
T2910	9784-9789	NN	denotes	joint
T2911	9790-9797	NNS	denotes	regions
T2912	9797-9798	.	denotes	.
T2913	9798-10036	sentence	denotes	Interestingly, HPLAP expression in the Gdf5-Cre transgenic GAC(A) line used for all subsequent breeding experiments was seen to precede LACZ expression during successive development of joints in the digits (Figure 1C) (unpublished data).
T2914	9799-9812	RB	denotes	Interestingly
T2915	9919-9923	VBN	denotes	seen
T2916	9812-9814	,	denotes	,
T2917	9814-9819	NN	denotes	HPLAP
T2918	9820-9830	NN	denotes	expression
T2919	9831-9833	IN	denotes	in
T2920	9834-9837	DT	denotes	the
T2921	9865-9869	NN	denotes	line
T2922	9838-9842	NN	denotes	Gdf5
T2923	9843-9846	NN	denotes	Cre
T2924	9842-9843	HYPH	denotes	-
T2925	9847-9857	JJ	denotes	transgenic
T2926	9858-9861	NN	denotes	GAC
T2927	9862-9863	NN	denotes	A
T2928	9861-9862	-LRB-	denotes	(
T2929	9863-9864	-RRB-	denotes	)
T2930	9870-9874	VBN	denotes	used
T2931	9875-9878	IN	denotes	for
T2932	9879-9882	DT	denotes	all
T2933	9903-9914	NNS	denotes	experiments
T2934	9883-9893	JJ	denotes	subsequent
T2935	9894-9902	NN	denotes	breeding
T2936	9915-9918	VBD	denotes	was
T2937	9924-9926	TO	denotes	to
T2938	9927-9934	VB	denotes	precede
T2939	9935-9939	NN	denotes	LACZ
T2940	9940-9950	NN	denotes	expression
T2941	9951-9957	IN	denotes	during
T2942	9958-9968	JJ	denotes	successive
T2943	9969-9980	NN	denotes	development
T2944	9981-9983	IN	denotes	of
T2945	9984-9990	NNS	denotes	joints
T2946	9991-9993	IN	denotes	in
T2947	9994-9997	DT	denotes	the
T2948	9998-10004	NNS	denotes	digits
T2949	10005-10006	-LRB-	denotes	(
T2950	10006-10012	NN	denotes	Figure
T2951	10013-10015	CD	denotes	1C
T2952	10015-10016	-RRB-	denotes	)
T2953	10017-10018	-LRB-	denotes	(
T2954	10030-10034	NNS	denotes	data
T2955	10018-10029	JJ	denotes	unpublished
T2956	10034-10035	-RRB-	denotes	)
T2957	10035-10036	.	denotes	.
T2958	10036-10186	sentence	denotes	These experiments clearly demonstrate that the Gdf5-Cre transgene expresses Cre recombinase and causes DNA recombination in developing joint regions.
T2959	10037-10042	DT	denotes	These
T2960	10043-10054	NNS	denotes	experiments
T2961	10063-10074	VBP	denotes	demonstrate
T2962	10055-10062	RB	denotes	clearly
T2963	10075-10079	IN	denotes	that
T2964	10103-10112	VBZ	denotes	expresses
T2965	10080-10083	DT	denotes	the
T2966	10093-10102	NN	denotes	transgene
T2967	10084-10088	NN	denotes	Gdf5
T2968	10089-10092	NN	denotes	Cre
T2969	10088-10089	HYPH	denotes	-
T2970	10113-10116	NN	denotes	Cre
T2971	10117-10128	NN	denotes	recombinase
T2972	10129-10132	CC	denotes	and
T2973	10133-10139	VBZ	denotes	causes
T2974	10140-10143	NN	denotes	DNA
T2975	10144-10157	NN	denotes	recombination
T2976	10158-10160	IN	denotes	in
T2977	10161-10171	VBG	denotes	developing
T2978	10178-10185	NNS	denotes	regions
T2979	10172-10177	NN	denotes	joint
T2980	10185-10186	.	denotes	.
T2981	10186-12005	sentence	denotes	Figure 1 A Genetic System to Drive Gene Recombination in Developing Joints (A) A 140-kb BAC from the Gdf5 locus was modified by inserting Cre-IRES-hPLAP into the translation start site of Gdf5 and used to make transgenic mice. Not to scale. See Materials and Methods for details. (B–E) Visualization of Gdf5-Cre driven recombination patterns based on activation of lacZ expression from the R26R Cre reporter allele. (B) LACZ activity is visible as blue staining in the ear (ea) and the joints of the shoulder (s), elbow (eb), wrist (w), knee (k), ankle (a), vertebra (vj), and phalanges (black arrowheads) of an E14.5 mouse embryo. (C) E14.5 hindlimb double-stained to show both HPLAP expression from the transgene (grey/purple staining) and LACZ expression from the rearranged R26R allele (blue staining). Note that both markers are visible in the oldest, proximal interphalangeal joint (black arrowhead), only HPLAP activity is visible in the more recently formed medial interphalangeal joint (black arrow), and neither HPLAP nor LACZ expression is visible in the youngest, most distal joint of the digit (white arrowhead). (D) Newborn (P0) forelimb with skin partially removed showing LACZ activity expressed in all phalangeal joints (red Salmon gal staining, black arrowheads) and regions of some tendons (asterisk). (E) Section through the most distal phalangeal joint of a P0 hindlimb stained with Alcian blue to mark cartilage showing LACZ expression (stained red) in all tissues of developing joints: articular cartilage (black arrowhead), precursors of ligaments and synovial membranes (black arrow), and cells where cavitation is occurring (asterisk). GAC(A) mice were crossed with lacZ ROSA26 Cre reporter strain (R26R) mice to analyze the pattern of Cre-mediated lacZ recombination throughout development.
T2982	11850-11853	NN	denotes	GAC
T2983	11854-11855	NN	denotes	A
T2984	11853-11854	-LRB-	denotes	(
T2985	11857-11861	NNS	denotes	mice
T2986	11855-11856	-RRB-	denotes	)
T2987	11867-11874	VBN	denotes	crossed
T2988	11862-11866	VBD	denotes	were
T2989	11875-11879	IN	denotes	with
T2990	11880-11884	NN	denotes	lacZ
T2991	11892-11895	NN	denotes	Cre
T2992	11885-11891	NN	denotes	ROSA26
T2993	11896-11904	NN	denotes	reporter
T2994	11905-11911	NN	denotes	strain
T2995	11919-11923	NNS	denotes	mice
T2996	11912-11913	-LRB-	denotes	(
T2997	11913-11917	NN	denotes	R26R
T2998	11917-11918	-RRB-	denotes	)
T2999	11924-11926	TO	denotes	to
T3000	11927-11934	VB	denotes	analyze
T3001	11935-11938	DT	denotes	the
T3002	11939-11946	NN	denotes	pattern
T3003	11947-11949	IN	denotes	of
T3004	11950-11953	NN	denotes	Cre
T3005	11954-11962	VBN	denotes	mediated
T3006	11953-11954	HYPH	denotes	-
T3007	11968-11981	NN	denotes	recombination
T3008	11963-11967	NN	denotes	lacZ
T3009	11982-11992	IN	denotes	throughout
T3010	11993-12004	NN	denotes	development
T3011	12004-12005	.	denotes	.
T3012	12005-12136	sentence	denotes	Joints in developing limbs begin forming in a proximal-distal pattern such that the shoulder joint forms prior to the elbow joint.
T3013	12006-12012	NNS	denotes	Joints
T3014	12033-12038	VBP	denotes	begin
T3015	12013-12015	IN	denotes	in
T3016	12016-12026	VBG	denotes	developing
T3017	12027-12032	NNS	denotes	limbs
T3018	12039-12046	VBG	denotes	forming
T3019	12047-12049	IN	denotes	in
T3020	12050-12051	DT	denotes	a
T3021	12068-12075	NN	denotes	pattern
T3022	12052-12060	JJ	denotes	proximal
T3023	12061-12067	JJ	denotes	distal
T3024	12060-12061	HYPH	denotes	-
T3025	12076-12080	JJ	denotes	such
T3026	12105-12110	VBZ	denotes	forms
T3027	12081-12085	IN	denotes	that
T3028	12086-12089	DT	denotes	the
T3029	12099-12104	NN	denotes	joint
T3030	12090-12098	NN	denotes	shoulder
T3031	12111-12116	RB	denotes	prior
T3032	12117-12119	IN	denotes	to
T3033	12120-12123	DT	denotes	the
T3034	12130-12135	NN	denotes	joint
T3035	12124-12129	NN	denotes	elbow
T3036	12135-12136	.	denotes	.
T3037	12136-12327	sentence	denotes	In addition, three major stages of early joint development have been defined by histology as (1) interzone formation, (2) three-layer interzone formation, and (3) cavitation (Mitrovic 1978).
T3038	12137-12139	IN	denotes	In
T3039	12206-12213	VBN	denotes	defined
T3040	12140-12148	NN	denotes	addition
T3041	12148-12150	,	denotes	,
T3042	12150-12155	CD	denotes	three
T3043	12162-12168	NNS	denotes	stages
T3044	12156-12161	JJ	denotes	major
T3045	12169-12171	IN	denotes	of
T3046	12172-12177	JJ	denotes	early
T3047	12184-12195	NN	denotes	development
T3048	12178-12183	NN	denotes	joint
T3049	12196-12200	VBP	denotes	have
T3050	12201-12205	VBN	denotes	been
T3051	12214-12216	IN	denotes	by
T3052	12217-12226	NN	denotes	histology
T3053	12227-12229	IN	denotes	as
T3054	12230-12231	-LRB-	denotes	(
T3055	12231-12232	LS	denotes	1
T3056	12244-12253	NN	denotes	formation
T3057	12232-12233	-RRB-	denotes	)
T3058	12234-12243	NN	denotes	interzone
T3059	12253-12255	,	denotes	,
T3060	12255-12256	-LRB-	denotes	(
T3061	12256-12257	LS	denotes	2
T3062	12281-12290	NN	denotes	formation
T3063	12257-12258	-RRB-	denotes	)
T3064	12259-12264	CD	denotes	three
T3065	12265-12270	NN	denotes	layer
T3066	12264-12265	HYPH	denotes	-
T3067	12271-12280	NN	denotes	interzone
T3068	12290-12292	,	denotes	,
T3069	12292-12295	CC	denotes	and
T3070	12296-12297	-LRB-	denotes	(
T3071	12297-12298	LS	denotes	3
T3072	12300-12310	NN	denotes	cavitation
T3073	12298-12299	-RRB-	denotes	)
T3074	12311-12312	-LRB-	denotes	(
T3075	12312-12320	NNP	denotes	Mitrovic
T3076	12321-12325	CD	denotes	1978
T3077	12325-12326	-RRB-	denotes	)
T3078	12326-12327	.	denotes	.
T3079	12327-12539	sentence	denotes	Consistent with the proximal-distal pattern of joint development in the limbs, LACZ activity is seen at embryonic day 12.5 (E12.5) in the more proximal joints, including the shoulder and knee (unpublished data).
T3080	12328-12338	JJ	denotes	Consistent
T3081	12424-12428	VBN	denotes	seen
T3082	12339-12343	IN	denotes	with
T3083	12344-12347	DT	denotes	the
T3084	12364-12371	NN	denotes	pattern
T3085	12348-12356	JJ	denotes	proximal
T3086	12357-12363	JJ	denotes	distal
T3087	12356-12357	HYPH	denotes	-
T3088	12372-12374	IN	denotes	of
T3089	12375-12380	NN	denotes	joint
T3090	12381-12392	NN	denotes	development
T3091	12393-12395	IN	denotes	in
T3092	12396-12399	DT	denotes	the
T3093	12400-12405	NNS	denotes	limbs
T3094	12405-12407	,	denotes	,
T3095	12407-12411	NN	denotes	LACZ
T3096	12412-12420	NN	denotes	activity
T3097	12421-12423	VBZ	denotes	is
T3098	12429-12431	IN	denotes	at
T3099	12432-12441	JJ	denotes	embryonic
T3100	12442-12445	NN	denotes	day
T3101	12446-12450	CD	denotes	12.5
T3102	12451-12452	-LRB-	denotes	(
T3103	12452-12457	NN	denotes	E12.5
T3104	12457-12458	-RRB-	denotes	)
T3105	12459-12461	IN	denotes	in
T3106	12462-12465	DT	denotes	the
T3107	12480-12486	NNS	denotes	joints
T3108	12466-12470	RBR	denotes	more
T3109	12471-12479	JJ	denotes	proximal
T3110	12486-12488	,	denotes	,
T3111	12488-12497	VBG	denotes	including
T3112	12498-12501	DT	denotes	the
T3113	12502-12510	NN	denotes	shoulder
T3114	12511-12514	CC	denotes	and
T3115	12515-12519	NN	denotes	knee
T3116	12520-12521	-LRB-	denotes	(
T3117	12533-12537	NNS	denotes	data
T3118	12521-12532	JJ	denotes	unpublished
T3119	12537-12538	-RRB-	denotes	)
T3120	12538-12539	.	denotes	.
T3121	12539-12741	sentence	denotes	By E14.5, LACZ expression is typically seen in all but the most distal joints of the limbs (Figure 1B and 1C), but with some variability in both strength and extent of expression from embryo to embryo.
T3122	12540-12542	IN	denotes	By
T3123	12579-12583	VBN	denotes	seen
T3124	12543-12548	NN	denotes	E14.5
T3125	12548-12550	,	denotes	,
T3126	12550-12554	NN	denotes	LACZ
T3127	12555-12565	NN	denotes	expression
T3128	12566-12568	VBZ	denotes	is
T3129	12569-12578	RB	denotes	typically
T3130	12584-12586	IN	denotes	in
T3131	12587-12590	DT	denotes	all
T3132	12591-12594	IN	denotes	but
T3133	12595-12598	DT	denotes	the
T3134	12611-12617	NNS	denotes	joints
T3135	12599-12603	RBS	denotes	most
T3136	12604-12610	JJ	denotes	distal
T3137	12618-12620	IN	denotes	of
T3138	12621-12624	DT	denotes	the
T3139	12625-12630	NNS	denotes	limbs
T3140	12631-12632	-LRB-	denotes	(
T3141	12639-12641	CD	denotes	1B
T3142	12632-12638	NN	denotes	Figure
T3143	12642-12645	CC	denotes	and
T3144	12646-12648	CD	denotes	1C
T3145	12648-12649	-RRB-	denotes	)
T3146	12649-12651	,	denotes	,
T3147	12651-12654	CC	denotes	but
T3148	12655-12659	IN	denotes	with
T3149	12660-12664	DT	denotes	some
T3150	12665-12676	NN	denotes	variability
T3151	12677-12679	IN	denotes	in
T3152	12680-12684	CC	denotes	both
T3153	12685-12693	NN	denotes	strength
T3154	12694-12697	CC	denotes	and
T3155	12698-12704	NN	denotes	extent
T3156	12705-12707	IN	denotes	of
T3157	12708-12718	NN	denotes	expression
T3158	12719-12723	IN	denotes	from
T3159	12724-12730	NN	denotes	embryo
T3160	12731-12733	IN	denotes	to
T3161	12734-12740	NN	denotes	embryo
T3162	12740-12741	.	denotes	.
T3163	12741-12924	sentence	denotes	The strongest-staining embryos often have additional staining in fingertips (not seen in the E14.5 embryo in Figure 1C, but clearly detectable in the E13.5 embryo shown in Figure 2).
T3164	12742-12745	DT	denotes	The
T3165	12765-12772	NNS	denotes	embryos
T3166	12746-12755	RBS	denotes	strongest
T3167	12756-12764	VBG	denotes	staining
T3168	12755-12756	HYPH	denotes	-
T3169	12779-12783	VBP	denotes	have
T3170	12773-12778	RB	denotes	often
T3171	12784-12794	JJ	denotes	additional
T3172	12795-12803	NN	denotes	staining
T3173	12804-12806	IN	denotes	in
T3174	12807-12817	NNS	denotes	fingertips
T3175	12818-12819	-LRB-	denotes	(
T3176	12823-12827	VBN	denotes	seen
T3177	12819-12822	RB	denotes	not
T3178	12828-12830	IN	denotes	in
T3179	12831-12834	DT	denotes	the
T3180	12841-12847	NN	denotes	embryo
T3181	12835-12840	NN	denotes	E14.5
T3182	12848-12850	IN	denotes	in
T3183	12851-12857	NN	denotes	Figure
T3184	12858-12860	CD	denotes	1C
T3185	12860-12862	,	denotes	,
T3186	12862-12865	CC	denotes	but
T3187	12866-12873	RB	denotes	clearly
T3188	12874-12884	JJ	denotes	detectable
T3189	12885-12887	IN	denotes	in
T3190	12888-12891	DT	denotes	the
T3191	12898-12904	NN	denotes	embryo
T3192	12892-12897	NN	denotes	E13.5
T3193	12905-12910	VBN	denotes	shown
T3194	12911-12913	IN	denotes	in
T3195	12914-12920	NN	denotes	Figure
T3196	12921-12922	CD	denotes	2
T3197	12922-12923	-RRB-	denotes	)
T3198	12923-12924	.	denotes	.
T3199	12924-13042	sentence	denotes	Sections through developing joints show that LACZ is present in many cells at the interzone stage (unpublished data).
T3200	12925-12933	NNS	denotes	Sections
T3201	12960-12964	VBP	denotes	show
T3202	12934-12941	IN	denotes	through
T3203	12942-12952	VBG	denotes	developing
T3204	12953-12959	NNS	denotes	joints
T3205	12965-12969	IN	denotes	that
T3206	12975-12977	VBZ	denotes	is
T3207	12970-12974	NN	denotes	LACZ
T3208	12978-12985	JJ	denotes	present
T3209	12986-12988	IN	denotes	in
T3210	12989-12993	JJ	denotes	many
T3211	12994-12999	NNS	denotes	cells
T3212	13000-13002	IN	denotes	at
T3213	13003-13006	DT	denotes	the
T3214	13017-13022	NN	denotes	stage
T3215	13007-13016	NN	denotes	interzone
T3216	13023-13024	-LRB-	denotes	(
T3217	13036-13040	NNS	denotes	data
T3218	13024-13035	JJ	denotes	unpublished
T3219	13040-13041	-RRB-	denotes	)
T3220	13041-13042	.	denotes	.
T3221	13042-13259	sentence	denotes	However, expression of LACZ in nearly 100% of joint cells is not achieved until the three-layer interzone stage (for example, in the knee joint at E14.5 or in any of the phalangeal joints at E16.5 (unpublished data).
T3222	13043-13050	RB	denotes	However
T3223	13108-13116	VBN	denotes	achieved
T3224	13050-13052	,	denotes	,
T3225	13052-13062	NN	denotes	expression
T3226	13063-13065	IN	denotes	of
T3227	13066-13070	NN	denotes	LACZ
T3228	13071-13073	IN	denotes	in
T3229	13074-13080	RB	denotes	nearly
T3230	13081-13084	CD	denotes	100
T3231	13084-13085	NN	denotes	%
T3232	13086-13088	IN	denotes	of
T3233	13089-13094	NN	denotes	joint
T3234	13095-13100	NNS	denotes	cells
T3235	13101-13103	VBZ	denotes	is
T3236	13104-13107	RB	denotes	not
T3237	13117-13122	IN	denotes	until
T3238	13123-13126	DT	denotes	the
T3239	13149-13154	NN	denotes	stage
T3240	13127-13132	CD	denotes	three
T3241	13133-13138	NN	denotes	layer
T3242	13132-13133	HYPH	denotes	-
T3243	13139-13148	NN	denotes	interzone
T3244	13155-13156	-LRB-	denotes	(
T3245	13156-13159	IN	denotes	for
T3246	13160-13167	NN	denotes	example
T3247	13167-13169	,	denotes	,
T3248	13169-13171	IN	denotes	in
T3249	13172-13175	DT	denotes	the
T3250	13181-13186	NN	denotes	joint
T3251	13176-13180	NN	denotes	knee
T3252	13187-13189	IN	denotes	at
T3253	13190-13195	NN	denotes	E14.5
T3254	13196-13198	CC	denotes	or
T3255	13199-13201	IN	denotes	in
T3256	13202-13205	DT	denotes	any
T3257	13206-13208	IN	denotes	of
T3258	13209-13212	DT	denotes	the
T3259	13224-13230	NNS	denotes	joints
T3260	13213-13223	JJ	denotes	phalangeal
T3261	13231-13233	IN	denotes	at
T3262	13234-13239	NN	denotes	E16.5
T3263	13240-13241	-LRB-	denotes	(
T3264	13253-13257	NNS	denotes	data
T3265	13241-13252	JJ	denotes	unpublished
T3266	13257-13258	-RRB-	denotes	)
T3267	13258-13259	.	denotes	.
T3268	13259-13385	sentence	denotes	Within the developing skeleton, Cre-mediated expression of LACZ remains strikingly specific to joints throughout development.
T3269	13260-13266	IN	denotes	Within
T3270	13324-13331	VBZ	denotes	remains
T3271	13267-13270	DT	denotes	the
T3272	13282-13290	NN	denotes	skeleton
T3273	13271-13281	VBG	denotes	developing
T3274	13290-13292	,	denotes	,
T3275	13292-13295	NN	denotes	Cre
T3276	13296-13304	VBN	denotes	mediated
T3277	13295-13296	HYPH	denotes	-
T3278	13305-13315	NN	denotes	expression
T3279	13316-13318	IN	denotes	of
T3280	13319-13323	NN	denotes	LACZ
T3281	13332-13342	RB	denotes	strikingly
T3282	13343-13351	JJ	denotes	specific
T3283	13352-13354	IN	denotes	to
T3284	13355-13361	NNS	denotes	joints
T3285	13362-13372	IN	denotes	throughout
T3286	13373-13384	NN	denotes	development
T3287	13384-13385	.	denotes	.
T3288	13385-13571	sentence	denotes	Furthermore, it is seen in all the structures of postnatal synovial joints including the articular cartilage, joint capsule, and synovial membrane (Figure 1D and 1E) (unpublished data).
T3289	13386-13397	RB	denotes	Furthermore
T3290	13405-13409	VBN	denotes	seen
T3291	13397-13399	,	denotes	,
T3292	13399-13401	PRP	denotes	it
T3293	13402-13404	VBZ	denotes	is
T3294	13410-13412	IN	denotes	in
T3295	13413-13416	PDT	denotes	all
T3296	13421-13431	NNS	denotes	structures
T3297	13417-13420	DT	denotes	the
T3298	13432-13434	IN	denotes	of
T3299	13435-13444	JJ	denotes	postnatal
T3300	13454-13460	NNS	denotes	joints
T3301	13445-13453	JJ	denotes	synovial
T3302	13461-13470	VBG	denotes	including
T3303	13471-13474	DT	denotes	the
T3304	13485-13494	NN	denotes	cartilage
T3305	13475-13484	JJ	denotes	articular
T3306	13494-13496	,	denotes	,
T3307	13496-13501	NN	denotes	joint
T3308	13502-13509	NN	denotes	capsule
T3309	13509-13511	,	denotes	,
T3310	13511-13514	CC	denotes	and
T3311	13515-13523	JJ	denotes	synovial
T3312	13524-13532	NN	denotes	membrane
T3313	13533-13534	-LRB-	denotes	(
T3314	13534-13540	NN	denotes	Figure
T3315	13541-13543	CD	denotes	1D
T3316	13544-13547	CC	denotes	and
T3317	13548-13550	CD	denotes	1E
T3318	13550-13551	-RRB-	denotes	)
T3319	13552-13553	-LRB-	denotes	(
T3320	13565-13569	NNS	denotes	data
T3321	13553-13564	JJ	denotes	unpublished
T3322	13569-13570	-RRB-	denotes	)
T3323	13570-13571	.	denotes	.
T3324	13571-13723	sentence	denotes	These patterns are consistent with the well-established expression of Gdf5 in interzone regions during embryonic development (Storm and Kingsley 1996).
T3325	13572-13577	DT	denotes	These
T3326	13578-13586	NNS	denotes	patterns
T3327	13587-13590	VBP	denotes	are
T3328	13591-13601	JJ	denotes	consistent
T3329	13602-13606	IN	denotes	with
T3330	13607-13610	DT	denotes	the
T3331	13628-13638	NN	denotes	expression
T3332	13611-13615	RB	denotes	well
T3333	13616-13627	VBN	denotes	established
T3334	13615-13616	HYPH	denotes	-
T3335	13639-13641	IN	denotes	of
T3336	13642-13646	NN	denotes	Gdf5
T3337	13647-13649	IN	denotes	in
T3338	13650-13659	NN	denotes	interzone
T3339	13660-13667	NNS	denotes	regions
T3340	13668-13674	IN	denotes	during
T3341	13675-13684	JJ	denotes	embryonic
T3342	13685-13696	NN	denotes	development
T3343	13697-13698	-LRB-	denotes	(
T3344	13698-13703	NNP	denotes	Storm
T3345	13704-13707	CC	denotes	and
T3346	13708-13716	NNP	denotes	Kingsley
T3347	13717-13721	CD	denotes	1996
T3348	13721-13722	-RRB-	denotes	)
T3349	13722-13723	.	denotes	.
T3350	13723-13980	sentence	denotes	Adult expression patterns of the Gdf5 gene are not as well characterized, but Gdf5 expression has previously been detected in adult articular cartilage using both RT-PCR and immunocytochemistry (Chang et al. 1994; Erlacher et al. 1998; Bobacz et al. 2002).
T3351	13724-13729	NN	denotes	Adult
T3352	13741-13749	NNS	denotes	patterns
T3353	13730-13740	NN	denotes	expression
T3354	13767-13770	VBP	denotes	are
T3355	13750-13752	IN	denotes	of
T3356	13753-13756	DT	denotes	the
T3357	13762-13766	NN	denotes	gene
T3358	13757-13761	NN	denotes	Gdf5
T3359	13771-13774	RB	denotes	not
T3360	13775-13777	RB	denotes	as
T3361	13783-13796	VBN	denotes	characterized
T3362	13778-13782	RB	denotes	well
T3363	13796-13798	,	denotes	,
T3364	13798-13801	CC	denotes	but
T3365	13802-13806	NN	denotes	Gdf5
T3366	13807-13817	NN	denotes	expression
T3367	13838-13846	VBN	denotes	detected
T3368	13818-13821	VBZ	denotes	has
T3369	13822-13832	RB	denotes	previously
T3370	13833-13837	VBN	denotes	been
T3371	13847-13849	IN	denotes	in
T3372	13850-13855	NN	denotes	adult
T3373	13866-13875	NN	denotes	cartilage
T3374	13856-13865	JJ	denotes	articular
T3375	13876-13881	VBG	denotes	using
T3376	13882-13886	CC	denotes	both
T3377	13890-13893	NN	denotes	PCR
T3378	13887-13889	NN	denotes	RT
T3379	13889-13890	HYPH	denotes	-
T3380	13894-13897	CC	denotes	and
T3381	13898-13917	NN	denotes	immunocytochemistry
T3382	13918-13919	-LRB-	denotes	(
T3383	13919-13924	NNP	denotes	Chang
T3384	13925-13927	FW	denotes	et
T3385	13928-13931	FW	denotes	al.
T3386	13932-13936	CD	denotes	1994
T3387	13936-13937	:	denotes	;
T3388	13938-13946	NNP	denotes	Erlacher
T3389	13947-13949	FW	denotes	et
T3390	13950-13953	FW	denotes	al.
T3391	13954-13958	CD	denotes	1998
T3392	13958-13959	:	denotes	;
T3393	13960-13966	NNP	denotes	Bobacz
T3394	13967-13969	FW	denotes	et
T3395	13970-13973	FW	denotes	al.
T3396	13974-13978	CD	denotes	2002
T3397	13978-13979	-RRB-	denotes	)
T3398	13979-13980	.	denotes	.
T3399	13980-15452	sentence	denotes	Figure 2 Bmpr1a Is Required for Webbing Regression and Apoptosis in Specific Regions of the Limb (A and B) Control E14.5 forelimb (A) compared to a, E14.5 mutant forelimb (B) showing webbing between digits 1 and 2 (arrowheads) and extra tissue at the posterior of digit 5 (arrows). (C) Gdf5-Cre induced lacZ expression from R26R in an E13.5 forelimb showing LACZ staining (blue) in metacarpal-phalangeal joints, between digits 1 and 2 (arrowhead), and in a region posterior to digit 5 (arrow). (D and E) Sections of E14.5 hindlimbs showing apoptosis visualized by TUNEL staining (green) and proliferation visualized by staining for histone H3 phosphorylation (red). Controls show strong, uniform TUNEL staining between digits 1 and 2 (D, arrowhead) while mutants show patchy TUNEL staining interspersed with mitotic cells in similar regions (E). Scale bar = 200 μm. (F) Quantitation of TUNEL staining and mitotic cells in the posterior region of the fifth digit shows apoptosis is reduced 30% while proliferation is increased 20% (asterisks indicate statistically significant difference). (G and H) By E15.5, interdigital tissue has regressed in controls (G, arrowhead). In contrast, tissue remains in mutants at this location, primarily derived from cells that have undergone Gdf5-Cre-mediated recombination that inactivates Bmpr1a function and activates expression of LACZ (H). Scale bar = 75 μm. Other sites besides limb joints also have Cre-mediated lacZ expression.
T3400	15381-15386	JJ	denotes	Other
T3401	15387-15392	NNS	denotes	sites
T3402	15418-15422	VBP	denotes	have
T3403	15393-15400	IN	denotes	besides
T3404	15401-15405	NN	denotes	limb
T3405	15406-15412	NNS	denotes	joints
T3406	15413-15417	RB	denotes	also
T3407	15423-15426	NN	denotes	Cre
T3408	15427-15435	VBN	denotes	mediated
T3409	15426-15427	HYPH	denotes	-
T3410	15441-15451	NN	denotes	expression
T3411	15436-15440	NN	denotes	lacZ
T3412	15451-15452	.	denotes	.
T3413	15452-15562	sentence	denotes	Starting at E13.5, LACZ activity is detected in an anterior and posterior domain of the limb bud (Figure 2C).
T3414	15453-15461	VBG	denotes	Starting
T3415	15489-15497	VBN	denotes	detected
T3416	15462-15464	IN	denotes	at
T3417	15465-15470	NN	denotes	E13.5
T3418	15470-15472	,	denotes	,
T3419	15472-15476	NN	denotes	LACZ
T3420	15477-15485	NN	denotes	activity
T3421	15486-15488	VBZ	denotes	is
T3422	15498-15500	IN	denotes	in
T3423	15501-15503	DT	denotes	an
T3424	15527-15533	NN	denotes	domain
T3425	15504-15512	JJ	denotes	anterior
T3426	15513-15516	CC	denotes	and
T3427	15517-15526	JJ	denotes	posterior
T3428	15534-15536	IN	denotes	of
T3429	15537-15540	DT	denotes	the
T3430	15546-15549	NN	denotes	bud
T3431	15541-15545	NN	denotes	limb
T3432	15550-15551	-LRB-	denotes	(
T3433	15551-15557	NN	denotes	Figure
T3434	15558-15560	CD	denotes	2C
T3435	15560-15561	-RRB-	denotes	)
T3436	15561-15562	.	denotes	.
T3437	15562-15744	sentence	denotes	At E14.5, LACZ activity is detectable in the developing ear pinnae, ribs, sternum, tissues in the face, and some regions of the brain and spinal cord (Figure 1B) (unpublished data).
T3438	15563-15565	IN	denotes	At
T3439	15587-15589	VBZ	denotes	is
T3440	15566-15571	NN	denotes	E14.5
T3441	15571-15573	,	denotes	,
T3442	15573-15577	NN	denotes	LACZ
T3443	15578-15586	NN	denotes	activity
T3444	15590-15600	JJ	denotes	detectable
T3445	15601-15603	IN	denotes	in
T3446	15604-15607	DT	denotes	the
T3447	15623-15629	NNS	denotes	pinnae
T3448	15608-15618	VBG	denotes	developing
T3449	15619-15622	NN	denotes	ear
T3450	15629-15631	,	denotes	,
T3451	15631-15635	NNS	denotes	ribs
T3452	15635-15637	,	denotes	,
T3453	15637-15644	NN	denotes	sternum
T3454	15644-15646	,	denotes	,
T3455	15646-15653	NNS	denotes	tissues
T3456	15654-15656	IN	denotes	in
T3457	15657-15660	DT	denotes	the
T3458	15661-15665	NN	denotes	face
T3459	15665-15667	,	denotes	,
T3460	15667-15670	CC	denotes	and
T3461	15671-15675	DT	denotes	some
T3462	15676-15683	NNS	denotes	regions
T3463	15684-15686	IN	denotes	of
T3464	15687-15690	DT	denotes	the
T3465	15691-15696	NN	denotes	brain
T3466	15697-15700	CC	denotes	and
T3467	15701-15707	JJ	denotes	spinal
T3468	15708-15712	NN	denotes	cord
T3469	15713-15714	-LRB-	denotes	(
T3470	15714-15720	NN	denotes	Figure
T3471	15721-15723	CD	denotes	1B
T3472	15723-15724	-RRB-	denotes	)
T3473	15725-15726	-LRB-	denotes	(
T3474	15738-15742	NNS	denotes	data
T3475	15726-15737	JJ	denotes	unpublished
T3476	15742-15743	-RRB-	denotes	)
T3477	15743-15744	.	denotes	.
T3478	15744-15926	sentence	denotes	At birth, LACZ is also expressed in tendons running along the vertebral column, regions of tendons in the wrist and ankle, and some tendon insertions (Figure 1D) (unpublished data).
T3479	15745-15747	IN	denotes	At
T3480	15768-15777	VBN	denotes	expressed
T3481	15748-15753	NN	denotes	birth
T3482	15753-15755	,	denotes	,
T3483	15755-15759	NN	denotes	LACZ
T3484	15760-15762	VBZ	denotes	is
T3485	15763-15767	RB	denotes	also
T3486	15778-15780	IN	denotes	in
T3487	15781-15788	NNS	denotes	tendons
T3488	15789-15796	VBG	denotes	running
T3489	15797-15802	IN	denotes	along
T3490	15803-15806	DT	denotes	the
T3491	15817-15823	NN	denotes	column
T3492	15807-15816	JJ	denotes	vertebral
T3493	15823-15825	,	denotes	,
T3494	15825-15832	NNS	denotes	regions
T3495	15833-15835	IN	denotes	of
T3496	15836-15843	NNS	denotes	tendons
T3497	15844-15846	IN	denotes	in
T3498	15847-15850	DT	denotes	the
T3499	15851-15856	NN	denotes	wrist
T3500	15857-15860	CC	denotes	and
T3501	15861-15866	NN	denotes	ankle
T3502	15866-15868	,	denotes	,
T3503	15868-15871	CC	denotes	and
T3504	15872-15876	DT	denotes	some
T3505	15884-15894	NNS	denotes	insertions
T3506	15877-15883	NN	denotes	tendon
T3507	15895-15896	-LRB-	denotes	(
T3508	15896-15902	NN	denotes	Figure
T3509	15903-15905	CD	denotes	1D
T3510	15905-15906	-RRB-	denotes	)
T3511	15907-15908	-LRB-	denotes	(
T3512	15920-15924	NNS	denotes	data
T3513	15908-15919	JJ	denotes	unpublished
T3514	15924-15925	-RRB-	denotes	)
T3515	15925-15926	.	denotes	.
T3516	15926-16115	sentence	denotes	By 5 wk of age, LACZ is also expressed in the hair follicles, ear cartilage, some cells in the growth plate of the long bones, and portions of the brain and spinal cord (unpublished data).
T3517	15927-15929	IN	denotes	By
T3518	15956-15965	VBN	denotes	expressed
T3519	15930-15931	CD	denotes	5
T3520	15932-15934	NNS	denotes	wk
T3521	15935-15937	IN	denotes	of
T3522	15938-15941	NN	denotes	age
T3523	15941-15943	,	denotes	,
T3524	15943-15947	NN	denotes	LACZ
T3525	15948-15950	VBZ	denotes	is
T3526	15951-15955	RB	denotes	also
T3527	15966-15968	IN	denotes	in
T3528	15969-15972	DT	denotes	the
T3529	15978-15987	NNS	denotes	follicles
T3530	15973-15977	NN	denotes	hair
T3531	15987-15989	,	denotes	,
T3532	15989-15992	NN	denotes	ear
T3533	15993-16002	NN	denotes	cartilage
T3534	16002-16004	,	denotes	,
T3535	16004-16008	DT	denotes	some
T3536	16009-16014	NNS	denotes	cells
T3537	16015-16017	IN	denotes	in
T3538	16018-16021	DT	denotes	the
T3539	16029-16034	NN	denotes	plate
T3540	16022-16028	NN	denotes	growth
T3541	16035-16037	IN	denotes	of
T3542	16038-16041	DT	denotes	the
T3543	16047-16052	NNS	denotes	bones
T3544	16042-16046	JJ	denotes	long
T3545	16052-16054	,	denotes	,
T3546	16054-16057	CC	denotes	and
T3547	16058-16066	NNS	denotes	portions
T3548	16067-16069	IN	denotes	of
T3549	16070-16073	DT	denotes	the
T3550	16074-16079	NN	denotes	brain
T3551	16080-16083	CC	denotes	and
T3552	16084-16090	JJ	denotes	spinal
T3553	16091-16095	NN	denotes	cord
T3554	16096-16097	-LRB-	denotes	(
T3555	16109-16113	NNS	denotes	data
T3556	16097-16108	JJ	denotes	unpublished
T3557	16113-16114	-RRB-	denotes	)
T3558	16114-16115	.	denotes	.
T3559	16115-16298	sentence	denotes	Surprisingly, 23 of 63, or 37% of transgenic mice analyzed also show some degree of wider “ectopic” LACZ expression, which can extend throughout many different tissues in the animal.
T3560	16116-16128	RB	denotes	Surprisingly
T3561	16180-16184	VBP	denotes	show
T3562	16128-16130	,	denotes	,
T3563	16130-16132	CD	denotes	23
T3564	16136-16138	CD	denotes	63
T3565	16133-16135	IN	denotes	of
T3566	16138-16140	,	denotes	,
T3567	16140-16142	CC	denotes	or
T3568	16143-16145	CD	denotes	37
T3569	16145-16146	NN	denotes	%
T3570	16147-16149	IN	denotes	of
T3571	16150-16160	JJ	denotes	transgenic
T3572	16161-16165	NNS	denotes	mice
T3573	16166-16174	VBN	denotes	analyzed
T3574	16175-16179	RB	denotes	also
T3575	16185-16189	DT	denotes	some
T3576	16190-16196	NN	denotes	degree
T3577	16197-16199	IN	denotes	of
T3578	16200-16205	JJR	denotes	wider
T3579	16221-16231	NN	denotes	expression
T3580	16206-16207	``	denotes	“
T3581	16207-16214	JJ	denotes	ectopic
T3582	16214-16215	''	denotes	”
T3583	16216-16220	NN	denotes	LACZ
T3584	16231-16233	,	denotes	,
T3585	16233-16238	WDT	denotes	which
T3586	16243-16249	VB	denotes	extend
T3587	16239-16242	MD	denotes	can
T3588	16250-16260	IN	denotes	throughout
T3589	16261-16265	JJ	denotes	many
T3590	16276-16283	NNS	denotes	tissues
T3591	16266-16275	JJ	denotes	different
T3592	16284-16286	IN	denotes	in
T3593	16287-16290	DT	denotes	the
T3594	16291-16297	NN	denotes	animal
T3595	16297-16298	.	denotes	.
T3596	16298-16532	sentence	denotes	However, sustained expression of the transgene itself, as assayed by HPLAP activity, is still restricted primarily to joints in animals that show evidence of more generalized recombination based on LACZ expression (unpublished data).
T3597	16299-16306	RB	denotes	However
T3598	16384-16386	VBZ	denotes	is
T3599	16306-16308	,	denotes	,
T3600	16308-16317	VBN	denotes	sustained
T3601	16318-16328	NN	denotes	expression
T3602	16329-16331	IN	denotes	of
T3603	16332-16335	DT	denotes	the
T3604	16336-16345	NN	denotes	transgene
T3605	16346-16352	PRP	denotes	itself
T3606	16352-16354	,	denotes	,
T3607	16354-16356	IN	denotes	as
T3608	16357-16364	VBN	denotes	assayed
T3609	16365-16367	IN	denotes	by
T3610	16368-16373	NN	denotes	HPLAP
T3611	16374-16382	NN	denotes	activity
T3612	16382-16384	,	denotes	,
T3613	16387-16392	RB	denotes	still
T3614	16393-16403	VBN	denotes	restricted
T3615	16404-16413	RB	denotes	primarily
T3616	16414-16416	IN	denotes	to
T3617	16417-16423	NNS	denotes	joints
T3618	16424-16426	IN	denotes	in
T3619	16427-16434	NNS	denotes	animals
T3620	16435-16439	WDT	denotes	that
T3621	16440-16444	VBP	denotes	show
T3622	16445-16453	NN	denotes	evidence
T3623	16454-16456	IN	denotes	of
T3624	16457-16461	RBR	denotes	more
T3625	16462-16473	VBN	denotes	generalized
T3626	16474-16487	NN	denotes	recombination
T3627	16488-16493	VBN	denotes	based
T3628	16494-16496	IN	denotes	on
T3629	16497-16501	NN	denotes	LACZ
T3630	16502-16512	NN	denotes	expression
T3631	16513-16514	-LRB-	denotes	(
T3632	16526-16530	NNS	denotes	data
T3633	16514-16525	JJ	denotes	unpublished
T3634	16530-16531	-RRB-	denotes	)
T3635	16531-16532	.	denotes	.
T3636	16532-16711	sentence	denotes	This suggests that in a fraction of animals, sporadic expression of Cre at some time early in development is sufficient to lead to both ectopic recombination and LACZ expression.
T3637	16533-16537	DT	denotes	This
T3638	16538-16546	VBZ	denotes	suggests
T3639	16547-16551	IN	denotes	that
T3640	16639-16641	VBZ	denotes	is
T3641	16552-16554	IN	denotes	in
T3642	16555-16556	DT	denotes	a
T3643	16557-16565	NN	denotes	fraction
T3644	16566-16568	IN	denotes	of
T3645	16569-16576	NNS	denotes	animals
T3646	16576-16578	,	denotes	,
T3647	16578-16586	JJ	denotes	sporadic
T3648	16587-16597	NN	denotes	expression
T3649	16598-16600	IN	denotes	of
T3650	16601-16604	NN	denotes	Cre
T3651	16605-16607	IN	denotes	at
T3652	16608-16612	DT	denotes	some
T3653	16613-16617	NN	denotes	time
T3654	16618-16623	RB	denotes	early
T3655	16624-16626	IN	denotes	in
T3656	16627-16638	NN	denotes	development
T3657	16642-16652	JJ	denotes	sufficient
T3658	16653-16655	TO	denotes	to
T3659	16656-16660	VB	denotes	lead
T3660	16661-16663	IN	denotes	to
T3661	16664-16668	CC	denotes	both
T3662	16677-16690	NN	denotes	recombination
T3663	16669-16676	JJ	denotes	ectopic
T3664	16691-16694	CC	denotes	and
T3665	16695-16699	NN	denotes	LACZ
T3666	16700-16710	NN	denotes	expression
T3667	16710-16711	.	denotes	.
T3668	16711-17005	sentence	denotes	While the fraction of animals with broader recombination patterns must be tracked and accounted for during experiments, these animals offer the potential benefit of revealing additional new functions of target genes that could be subsequently studied with additional site-specific Cre drivers.
T3669	16712-16717	IN	denotes	While
T3670	16786-16793	VBN	denotes	tracked
T3671	16718-16721	DT	denotes	the
T3672	16722-16730	NN	denotes	fraction
T3673	16731-16733	IN	denotes	of
T3674	16734-16741	NNS	denotes	animals
T3675	16742-16746	IN	denotes	with
T3676	16747-16754	JJR	denotes	broader
T3677	16769-16777	NNS	denotes	patterns
T3678	16755-16768	NN	denotes	recombination
T3679	16778-16782	MD	denotes	must
T3680	16783-16785	VB	denotes	be
T3681	16846-16851	VBP	denotes	offer
T3682	16794-16797	CC	denotes	and
T3683	16798-16807	VBN	denotes	accounted
T3684	16808-16811	IN	denotes	for
T3685	16812-16818	IN	denotes	during
T3686	16819-16830	NNS	denotes	experiments
T3687	16830-16832	,	denotes	,
T3688	16832-16837	DT	denotes	these
T3689	16838-16845	NNS	denotes	animals
T3690	16852-16855	DT	denotes	the
T3691	16866-16873	NN	denotes	benefit
T3692	16856-16865	JJ	denotes	potential
T3693	16874-16876	IN	denotes	of
T3694	16877-16886	VBG	denotes	revealing
T3695	16887-16897	JJ	denotes	additional
T3696	16902-16911	NNS	denotes	functions
T3697	16898-16901	JJ	denotes	new
T3698	16912-16914	IN	denotes	of
T3699	16915-16921	NN	denotes	target
T3700	16922-16927	NNS	denotes	genes
T3701	16928-16932	WDT	denotes	that
T3702	16955-16962	VBN	denotes	studied
T3703	16933-16938	MD	denotes	could
T3704	16939-16941	VB	denotes	be
T3705	16942-16954	RB	denotes	subsequently
T3706	16963-16967	IN	denotes	with
T3707	16968-16978	JJ	denotes	additional
T3708	16997-17004	NNS	denotes	drivers
T3709	16979-16983	NN	denotes	site
T3710	16983-16984	HYPH	denotes	-
T3711	16984-16992	JJ	denotes	specific
T3712	16993-16996	NN	denotes	Cre
T3713	17004-17005	.	denotes	.
T3948	17007-17011	NN	denotes	Gdf5
T3949	17012-17015	NN	denotes	Cre
T3950	17011-17012	HYPH	denotes	-
T3951	17028-17035	NNS	denotes	Animals
T3952	17015-17016	HYPH	denotes	/
T3953	17016-17027	NN	denotes	Bmpr1afloxP
T3954	17036-17043	VBP	denotes	Survive
T3955	17044-17046	IN	denotes	to
T3956	17047-17056	NN	denotes	Adulthood
T3957	17057-17061	IN	denotes	with
T3958	17062-17065	NN	denotes	Ear
T3959	17086-17093	NNS	denotes	Defects
T3960	17065-17067	,	denotes	,
T3961	17067-17074	NN	denotes	Webbing
T3962	17074-17076	,	denotes	,
T3963	17076-17079	CC	denotes	and
T3964	17080-17085	NN	denotes	Joint
T3965	17093-17193	sentence	denotes	We next used the Gdf5-Cre system to test the role of BMP signaling during normal joint development.
T3966	17094-17096	PRP	denotes	We
T3967	17102-17106	VBD	denotes	used
T3968	17097-17101	RB	denotes	next
T3969	17107-17110	DT	denotes	the
T3970	17120-17126	NN	denotes	system
T3971	17111-17115	NN	denotes	Gdf5
T3972	17116-17119	NN	denotes	Cre
T3973	17115-17116	HYPH	denotes	-
T3974	17127-17129	TO	denotes	to
T3975	17130-17134	VB	denotes	test
T3976	17135-17138	DT	denotes	the
T3977	17139-17143	NN	denotes	role
T3978	17144-17146	IN	denotes	of
T3979	17147-17150	NN	denotes	BMP
T3980	17151-17160	NN	denotes	signaling
T3981	17161-17167	IN	denotes	during
T3982	17168-17174	JJ	denotes	normal
T3983	17181-17192	NN	denotes	development
T3984	17175-17180	NN	denotes	joint
T3985	17192-17193	.	denotes	.
T3986	17193-17484	sentence	denotes	Gdf5-Cre transgenic mice were bred to animals carrying a conditional floxed allele of the Bmpr1a locus (Mishina et al. 2002), usually in the presence of the R26R reporter allele to facilitate simultaneous visualization of Cre-mediated recombination patterns (see typical cross in Figure 3).
T3987	17194-17198	NN	denotes	Gdf5
T3988	17199-17202	NN	denotes	Cre
T3989	17198-17199	HYPH	denotes	-
T3990	17214-17218	NNS	denotes	mice
T3991	17203-17213	JJ	denotes	transgenic
T3992	17224-17228	VBN	denotes	bred
T3993	17219-17223	VBD	denotes	were
T3994	17229-17231	IN	denotes	to
T3995	17232-17239	NNS	denotes	animals
T3996	17240-17248	VBG	denotes	carrying
T3997	17249-17250	DT	denotes	a
T3998	17270-17276	NN	denotes	allele
T3999	17251-17262	JJ	denotes	conditional
T4000	17263-17269	VBN	denotes	floxed
T4001	17277-17279	IN	denotes	of
T4002	17280-17283	DT	denotes	the
T4003	17291-17296	NN	denotes	locus
T4004	17284-17290	NN	denotes	Bmpr1a
T4005	17297-17298	-LRB-	denotes	(
T4006	17298-17305	NNP	denotes	Mishina
T4007	17306-17308	FW	denotes	et
T4008	17309-17312	FW	denotes	al.
T4009	17313-17317	CD	denotes	2002
T4010	17317-17318	-RRB-	denotes	)
T4011	17318-17320	,	denotes	,
T4012	17320-17327	RB	denotes	usually
T4013	17328-17330	IN	denotes	in
T4014	17331-17334	DT	denotes	the
T4015	17335-17343	NN	denotes	presence
T4016	17344-17346	IN	denotes	of
T4017	17347-17350	DT	denotes	the
T4018	17365-17371	NN	denotes	allele
T4019	17351-17355	NN	denotes	R26R
T4020	17356-17364	NN	denotes	reporter
T4021	17372-17374	TO	denotes	to
T4022	17375-17385	VB	denotes	facilitate
T4023	17386-17398	JJ	denotes	simultaneous
T4024	17399-17412	NN	denotes	visualization
T4025	17413-17415	IN	denotes	of
T4026	17416-17419	NN	denotes	Cre
T4027	17420-17428	VBN	denotes	mediated
T4028	17419-17420	HYPH	denotes	-
T4029	17443-17451	NNS	denotes	patterns
T4030	17429-17442	NN	denotes	recombination
T4031	17452-17453	-LRB-	denotes	(
T4032	17453-17456	VB	denotes	see
T4033	17457-17464	JJ	denotes	typical
T4034	17465-17470	NN	denotes	cross
T4035	17471-17473	IN	denotes	in
T4036	17474-17480	NN	denotes	Figure
T4037	17481-17482	CD	denotes	3
T4038	17482-17483	-RRB-	denotes	)
T4039	17483-17484	.	denotes	.
T4040	17484-17628	sentence	denotes	PCR amplification confirmed that a key exon of the Bmpr1a gene was deleted in mice that also carried the Gdf5-Cre transgene (unpublished data).
T4041	17485-17488	NN	denotes	PCR
T4042	17489-17502	NN	denotes	amplification
T4043	17503-17512	VBD	denotes	confirmed
T4044	17513-17517	IN	denotes	that
T4045	17552-17559	VBN	denotes	deleted
T4046	17518-17519	DT	denotes	a
T4047	17524-17528	NN	denotes	exon
T4048	17520-17523	JJ	denotes	key
T4049	17529-17531	IN	denotes	of
T4050	17532-17535	DT	denotes	the
T4051	17543-17547	NN	denotes	gene
T4052	17536-17542	NN	denotes	Bmpr1a
T4053	17548-17551	VBD	denotes	was
T4054	17560-17562	IN	denotes	in
T4055	17563-17567	NNS	denotes	mice
T4056	17568-17572	WDT	denotes	that
T4057	17578-17585	VBD	denotes	carried
T4058	17573-17577	RB	denotes	also
T4059	17586-17589	DT	denotes	the
T4060	17599-17608	NN	denotes	transgene
T4061	17590-17594	NN	denotes	Gdf5
T4062	17595-17598	NN	denotes	Cre
T4063	17594-17595	HYPH	denotes	-
T4064	17609-17610	-LRB-	denotes	(
T4065	17622-17626	NNS	denotes	data
T4066	17610-17621	JJ	denotes	unpublished
T4067	17626-17627	-RRB-	denotes	)
T4068	17627-17628	.	denotes	.
T4069	17628-17797	sentence	denotes	Previous studies have shown that the recombined Bmpr1afloxP allele mimics a null allele of the Bmpr1a locus when transmitted through the germline (Mishina et al. 2002).
T4070	17629-17637	JJ	denotes	Previous
T4071	17638-17645	NNS	denotes	studies
T4072	17651-17656	VBN	denotes	shown
T4073	17646-17650	VBP	denotes	have
T4074	17657-17661	IN	denotes	that
T4075	17696-17702	VBZ	denotes	mimics
T4076	17662-17665	DT	denotes	the
T4077	17689-17695	NN	denotes	allele
T4078	17666-17676	JJ	denotes	recombined
T4079	17677-17688	NN	denotes	Bmpr1afloxP
T4080	17703-17704	DT	denotes	a
T4081	17710-17716	NN	denotes	allele
T4082	17705-17709	JJ	denotes	null
T4083	17717-17719	IN	denotes	of
T4084	17720-17723	DT	denotes	the
T4085	17731-17736	NN	denotes	locus
T4086	17724-17730	NN	denotes	Bmpr1a
T4087	17737-17741	WRB	denotes	when
T4088	17742-17753	VBN	denotes	transmitted
T4089	17754-17761	IN	denotes	through
T4090	17762-17765	DT	denotes	the
T4091	17766-17774	NN	denotes	germline
T4092	17775-17776	-LRB-	denotes	(
T4093	17776-17783	NNP	denotes	Mishina
T4094	17784-17786	FW	denotes	et
T4095	17787-17790	FW	denotes	al.
T4096	17791-17795	CD	denotes	2002
T4097	17795-17796	-RRB-	denotes	)
T4098	17796-17797	.	denotes	.
T4099	17797-18056	sentence	denotes	The Gdf5-Cre/Bmpr1afloxP conditional knockout mice were viable and survived to adulthood, showing that the Gdf5-Cre driver can bypass the early embryonic lethality previously reported in animals with a null mutation in the Bmpr1a locus (Mishina et al. 1995).
T4100	17798-17801	DT	denotes	The
T4101	17844-17848	NNS	denotes	mice
T4102	17802-17806	NN	denotes	Gdf5
T4103	17807-17810	NN	denotes	Cre
T4104	17806-17807	HYPH	denotes	-
T4105	17811-17822	NN	denotes	Bmpr1afloxP
T4106	17810-17811	HYPH	denotes	/
T4107	17835-17843	NN	denotes	knockout
T4108	17823-17834	JJ	denotes	conditional
T4109	17849-17853	VBD	denotes	were
T4110	17854-17860	JJ	denotes	viable
T4111	17861-17864	CC	denotes	and
T4112	17865-17873	VBD	denotes	survived
T4113	17874-17876	IN	denotes	to
T4114	17877-17886	NN	denotes	adulthood
T4115	17886-17888	,	denotes	,
T4116	17888-17895	VBG	denotes	showing
T4117	17896-17900	IN	denotes	that
T4118	17925-17931	VB	denotes	bypass
T4119	17901-17904	DT	denotes	the
T4120	17914-17920	NN	denotes	driver
T4121	17905-17909	NN	denotes	Gdf5
T4122	17910-17913	NN	denotes	Cre
T4123	17909-17910	HYPH	denotes	-
T4124	17921-17924	MD	denotes	can
T4125	17932-17935	DT	denotes	the
T4126	17952-17961	NN	denotes	lethality
T4127	17936-17941	JJ	denotes	early
T4128	17942-17951	JJ	denotes	embryonic
T4129	17962-17972	RB	denotes	previously
T4130	17973-17981	VBN	denotes	reported
T4131	17982-17984	IN	denotes	in
T4132	17985-17992	NNS	denotes	animals
T4133	17993-17997	IN	denotes	with
T4134	17998-17999	DT	denotes	a
T4135	18005-18013	NN	denotes	mutation
T4136	18000-18004	JJ	denotes	null
T4137	18014-18016	IN	denotes	in
T4138	18017-18020	DT	denotes	the
T4139	18028-18033	NN	denotes	locus
T4140	18021-18027	NN	denotes	Bmpr1a
T4141	18034-18035	-LRB-	denotes	(
T4142	18035-18042	NNP	denotes	Mishina
T4143	18043-18045	FW	denotes	et
T4144	18046-18049	FW	denotes	al.
T4145	18050-18054	CD	denotes	1995
T4146	18054-18055	-RRB-	denotes	)
T4147	18055-18056	.	denotes	.
T4148	18056-18946	sentence	denotes	Figure 3 Gdf5-Cre-Mediated Deletion of Bmpr1a (A) Breeding strategy simultaneously deletes Bmpr1afloxP and allows visualization of Gdf5-Cre-mediated recombination by lacZ expression from R26R. (B–E) 5-week-old mutant and control mice stained with Alcian blue to mark cartilage and alizarin red to mark bone. (B) Ankle of control with strong blue staining lining each joint (arrowheads). (C) Ankle of mutant showing an absence of blue staining in most regions (arrowheads) and a joint fusion between the central (c) and second (2) tarsals (arrow). (D) Control and (E) mutant metatarsal/phalangeal joint which lacks blue staining in articular regions (arrowheads) but retains staining in the growth plate (asterisks). (F) Control forelimb. (G) Mutant forelimb with webbing between the first and second digit (black arrowhead). The viable Gdf5-Cre/Bmpr1afloxP mice showed several phenotypes.
T4149	18883-18886	DT	denotes	The
T4150	18915-18919	NNS	denotes	mice
T4151	18887-18893	JJ	denotes	viable
T4152	18894-18898	NN	denotes	Gdf5
T4153	18899-18902	NN	denotes	Cre
T4154	18898-18899	HYPH	denotes	-
T4155	18903-18914	NN	denotes	Bmpr1afloxP
T4156	18902-18903	HYPH	denotes	/
T4157	18920-18926	VBD	denotes	showed
T4158	18927-18934	JJ	denotes	several
T4159	18935-18945	NNS	denotes	phenotypes
T4160	18945-18946	.	denotes	.
T4161	18946-19139	sentence	denotes	First, the conditional knockout mice had shorter ears that often lay flatter against their heads than controls (controls 13.1 ± 0.1 mm long, n = 38; mutants 11.8 ± 0.2 mm, n = 11; p < 0.0001).
T4162	18947-18952	RB	denotes	First
T4163	18984-18987	VBD	denotes	had
T4164	18952-18954	,	denotes	,
T4165	18954-18957	DT	denotes	the
T4166	18979-18983	NNS	denotes	mice
T4167	18958-18969	JJ	denotes	conditional
T4168	18970-18978	NN	denotes	knockout
T4169	18988-18995	JJR	denotes	shorter
T4170	18996-19000	NNS	denotes	ears
T4171	19001-19005	WDT	denotes	that
T4172	19012-19015	VBP	denotes	lay
T4173	19006-19011	RB	denotes	often
T4174	19016-19023	JJR	denotes	flatter
T4175	19024-19031	IN	denotes	against
T4176	19032-19037	PRP$	denotes	their
T4177	19038-19043	NNS	denotes	heads
T4178	19044-19048	IN	denotes	than
T4179	19049-19057	NNS	denotes	controls
T4180	19058-19059	-LRB-	denotes	(
T4181	19131-19137	CD	denotes	0.0001
T4182	19059-19067	NNS	denotes	controls
T4183	19079-19081	NNS	denotes	mm
T4184	19068-19072	CD	denotes	13.1
T4185	19075-19078	CD	denotes	0.1
T4186	19073-19074	SYM	denotes	±
T4187	19082-19086	RB	denotes	long
T4188	19086-19088	,	denotes	,
T4189	19088-19089	NN	denotes	n
T4190	19092-19094	CD	denotes	38
T4191	19090-19091	SYM	denotes	=
T4192	19094-19095	:	denotes	;
T4193	19096-19103	NNS	denotes	mutants
T4194	19115-19117	NNS	denotes	mm
T4195	19104-19108	CD	denotes	11.8
T4196	19111-19114	CD	denotes	0.2
T4197	19109-19110	SYM	denotes	±
T4198	19117-19119	,	denotes	,
T4199	19119-19120	NN	denotes	n
T4200	19123-19125	CD	denotes	11
T4201	19121-19122	SYM	denotes	=
T4202	19125-19126	:	denotes	;
T4203	19127-19128	NN	denotes	p
T4204	19129-19130	SYM	denotes	<
T4205	19137-19138	-RRB-	denotes	)
T4206	19138-19139	.	denotes	.
T4207	19139-19365	sentence	denotes	BMP signaling is known to be required for growth of the external ear of mice (Kingsley et al. 1992), and this phenotype likely reflects loss of Bmpr1a function in the fraction of ear cells that express the Gdf5-Cre transgene.
T4208	19140-19143	NN	denotes	BMP
T4209	19144-19153	NN	denotes	signaling
T4210	19157-19162	VBN	denotes	known
T4211	19154-19156	VBZ	denotes	is
T4212	19163-19165	TO	denotes	to
T4213	19169-19177	VBN	denotes	required
T4214	19166-19168	VB	denotes	be
T4215	19178-19181	IN	denotes	for
T4216	19182-19188	NN	denotes	growth
T4217	19189-19191	IN	denotes	of
T4218	19192-19195	DT	denotes	the
T4219	19205-19208	NN	denotes	ear
T4220	19196-19204	JJ	denotes	external
T4221	19209-19211	IN	denotes	of
T4222	19212-19216	NNS	denotes	mice
T4223	19217-19218	-LRB-	denotes	(
T4224	19218-19226	NNP	denotes	Kingsley
T4225	19227-19229	FW	denotes	et
T4226	19230-19233	FW	denotes	al.
T4227	19234-19238	CD	denotes	1992
T4228	19238-19239	-RRB-	denotes	)
T4229	19239-19241	,	denotes	,
T4230	19241-19244	CC	denotes	and
T4231	19245-19249	DT	denotes	this
T4232	19250-19259	NN	denotes	phenotype
T4233	19267-19275	VBZ	denotes	reflects
T4234	19260-19266	RB	denotes	likely
T4235	19276-19280	NN	denotes	loss
T4236	19281-19283	IN	denotes	of
T4237	19284-19290	NN	denotes	Bmpr1a
T4238	19291-19299	NN	denotes	function
T4239	19300-19302	IN	denotes	in
T4240	19303-19306	DT	denotes	the
T4241	19307-19315	NN	denotes	fraction
T4242	19316-19318	IN	denotes	of
T4243	19319-19322	NN	denotes	ear
T4244	19323-19328	NNS	denotes	cells
T4245	19329-19333	WDT	denotes	that
T4246	19334-19341	VBP	denotes	express
T4247	19342-19345	DT	denotes	the
T4248	19355-19364	NN	denotes	transgene
T4249	19346-19350	NN	denotes	Gdf5
T4250	19351-19354	NN	denotes	Cre
T4251	19350-19351	HYPH	denotes	-
T4252	19364-19365	.	denotes	.
T4253	19365-19631	sentence	denotes	Most mutant mice also showed soft tissue syndactyly or retention of webbing between the first and second digits of their feet, a phenotype that was more frequent and more severe in the forelimbs (201 of 220, or 91%, of forefeet and 109 of 220, or 50%, of hindfeet).
T4254	19366-19370	JJS	denotes	Most
T4255	19378-19382	NNS	denotes	mice
T4256	19371-19377	NN	denotes	mutant
T4257	19388-19394	VBD	denotes	showed
T4258	19383-19387	RB	denotes	also
T4259	19395-19399	JJ	denotes	soft
T4260	19400-19406	NN	denotes	tissue
T4261	19407-19417	NN	denotes	syndactyly
T4262	19418-19420	CC	denotes	or
T4263	19421-19430	NN	denotes	retention
T4264	19431-19433	IN	denotes	of
T4265	19434-19441	NN	denotes	webbing
T4266	19442-19449	IN	denotes	between
T4267	19450-19453	DT	denotes	the
T4268	19471-19477	NNS	denotes	digits
T4269	19454-19459	JJ	denotes	first
T4270	19460-19463	CC	denotes	and
T4271	19464-19470	JJ	denotes	second
T4272	19478-19480	IN	denotes	of
T4273	19481-19486	PRP$	denotes	their
T4274	19487-19491	NNS	denotes	feet
T4275	19491-19493	,	denotes	,
T4276	19493-19494	DT	denotes	a
T4277	19495-19504	NN	denotes	phenotype
T4278	19505-19509	WDT	denotes	that
T4279	19510-19513	VBD	denotes	was
T4280	19514-19518	RBR	denotes	more
T4281	19519-19527	JJ	denotes	frequent
T4282	19528-19531	CC	denotes	and
T4283	19532-19536	RBR	denotes	more
T4284	19537-19543	JJ	denotes	severe
T4285	19544-19546	IN	denotes	in
T4286	19547-19550	DT	denotes	the
T4287	19551-19560	NNS	denotes	forelimbs
T4288	19561-19562	-LRB-	denotes	(
T4289	19569-19572	CD	denotes	220
T4290	19562-19565	CD	denotes	201
T4291	19566-19568	IN	denotes	of
T4292	19572-19574	,	denotes	,
T4293	19574-19576	CC	denotes	or
T4294	19577-19579	CD	denotes	91
T4295	19579-19580	NN	denotes	%
T4296	19580-19582	,	denotes	,
T4297	19582-19584	IN	denotes	of
T4298	19585-19593	NNS	denotes	forefeet
T4299	19594-19597	CC	denotes	and
T4300	19598-19601	CD	denotes	109
T4301	19605-19608	CD	denotes	220
T4302	19602-19604	IN	denotes	of
T4303	19608-19610	,	denotes	,
T4304	19610-19612	CC	denotes	or
T4305	19613-19615	CD	denotes	50
T4306	19615-19616	NN	denotes	%
T4307	19616-19618	,	denotes	,
T4308	19618-19620	IN	denotes	of
T4309	19621-19629	NN	denotes	hindfeet
T4310	19629-19630	-RRB-	denotes	)
T4311	19630-19631	.	denotes	.
T4312	19631-19725	sentence	denotes	Finally, mutant animals showed obvious skeletal changes in whole-mount skeletal preparations.
T4313	19632-19639	RB	denotes	Finally
T4314	19656-19662	VBD	denotes	showed
T4315	19639-19641	,	denotes	,
T4316	19641-19647	NN	denotes	mutant
T4317	19648-19655	NNS	denotes	animals
T4318	19663-19670	JJ	denotes	obvious
T4319	19680-19687	NNS	denotes	changes
T4320	19671-19679	JJ	denotes	skeletal
T4321	19688-19690	IN	denotes	in
T4322	19691-19696	JJ	denotes	whole
T4323	19697-19702	NN	denotes	mount
T4324	19696-19697	HYPH	denotes	-
T4325	19712-19724	NNS	denotes	preparations
T4326	19703-19711	JJ	denotes	skeletal
T4327	19724-19725	.	denotes	.
T4328	19725-19846	sentence	denotes	At some sites in the ankles, joints seemed to be missing entirely, with fusion of bones that would normally be separate.
T4329	19726-19728	IN	denotes	At
T4330	19762-19768	VBD	denotes	seemed
T4331	19729-19733	DT	denotes	some
T4332	19734-19739	NNS	denotes	sites
T4333	19740-19742	IN	denotes	in
T4334	19743-19746	DT	denotes	the
T4335	19747-19753	NNS	denotes	ankles
T4336	19753-19755	,	denotes	,
T4337	19755-19761	NNS	denotes	joints
T4338	19769-19771	TO	denotes	to
T4339	19772-19774	VB	denotes	be
T4340	19775-19782	VBG	denotes	missing
T4341	19783-19791	RB	denotes	entirely
T4342	19791-19793	,	denotes	,
T4343	19793-19797	IN	denotes	with
T4344	19798-19804	NN	denotes	fusion
T4345	19805-19807	IN	denotes	of
T4346	19808-19813	NNS	denotes	bones
T4347	19814-19818	WDT	denotes	that
T4348	19834-19836	VB	denotes	be
T4349	19819-19824	MD	denotes	would
T4350	19825-19833	RB	denotes	normally
T4351	19837-19845	JJ	denotes	separate
T4352	19845-19846	.	denotes	.
T4353	19846-20049	sentence	denotes	For example, the second distal tarsal was fused to the central tarsal bone in every conditional knockout animal examined (18 of 18), a phenotype not observed in controls (zero of 18) (Figure 3B and 3C).
T4354	19847-19850	IN	denotes	For
T4355	19889-19894	VBN	denotes	fused
T4356	19851-19858	NN	denotes	example
T4357	19858-19860	,	denotes	,
T4358	19860-19863	DT	denotes	the
T4359	19878-19884	JJ	denotes	tarsal
T4360	19864-19870	JJ	denotes	second
T4361	19871-19877	JJ	denotes	distal
T4362	19885-19888	VBD	denotes	was
T4363	19895-19897	IN	denotes	to
T4364	19898-19901	DT	denotes	the
T4365	19917-19921	NN	denotes	bone
T4366	19902-19909	JJ	denotes	central
T4367	19910-19916	JJ	denotes	tarsal
T4368	19922-19924	IN	denotes	in
T4369	19925-19930	DT	denotes	every
T4370	19952-19958	NN	denotes	animal
T4371	19931-19942	JJ	denotes	conditional
T4372	19943-19951	NN	denotes	knockout
T4373	19959-19967	VBN	denotes	examined
T4374	19968-19969	-LRB-	denotes	(
T4375	19975-19977	CD	denotes	18
T4376	19969-19971	CD	denotes	18
T4377	19972-19974	IN	denotes	of
T4378	19977-19978	-RRB-	denotes	)
T4379	19978-19980	,	denotes	,
T4380	19980-19981	DT	denotes	a
T4381	19982-19991	NN	denotes	phenotype
T4382	19992-19995	RB	denotes	not
T4383	19996-20004	VBN	denotes	observed
T4384	20005-20007	IN	denotes	in
T4385	20008-20016	NNS	denotes	controls
T4386	20017-20018	-LRB-	denotes	(
T4387	20026-20028	CD	denotes	18
T4388	20018-20022	CD	denotes	zero
T4389	20023-20025	IN	denotes	of
T4390	20028-20029	-RRB-	denotes	)
T4391	20030-20031	-LRB-	denotes	(
T4392	20031-20037	NN	denotes	Figure
T4393	20038-20040	CD	denotes	3B
T4394	20041-20044	CC	denotes	and
T4395	20045-20047	CD	denotes	3C
T4396	20047-20048	-RRB-	denotes	)
T4397	20048-20049	.	denotes	.
T4398	20049-20212	sentence	denotes	At other locations, joints had clearly formed but showed dramatic loss of staining with the cartilage matrix marker Alcian blue (Figure 3B–3E) (unpublished data).
T4399	20050-20052	IN	denotes	At
T4400	20089-20095	VBN	denotes	formed
T4401	20053-20058	JJ	denotes	other
T4402	20059-20068	NNS	denotes	locations
T4403	20068-20070	,	denotes	,
T4404	20070-20076	NNS	denotes	joints
T4405	20077-20080	VBD	denotes	had
T4406	20081-20088	RB	denotes	clearly
T4407	20096-20099	CC	denotes	but
T4408	20100-20106	VBD	denotes	showed
T4409	20107-20115	JJ	denotes	dramatic
T4410	20116-20120	NN	denotes	loss
T4411	20121-20123	IN	denotes	of
T4412	20124-20132	NN	denotes	staining
T4413	20133-20137	IN	denotes	with
T4414	20138-20141	DT	denotes	the
T4415	20159-20165	NN	denotes	marker
T4416	20142-20151	NN	denotes	cartilage
T4417	20152-20158	NN	denotes	matrix
T4418	20166-20172	JJ	denotes	Alcian
T4419	20173-20177	NN	denotes	blue
T4420	20178-20179	-LRB-	denotes	(
T4421	20186-20188	NN	denotes	3B
T4422	20179-20185	NN	denotes	Figure
T4423	20188-20189	SYM	denotes	–
T4424	20189-20191	NN	denotes	3E
T4425	20191-20192	-RRB-	denotes	)
T4426	20193-20194	-LRB-	denotes	(
T4427	20206-20210	NNS	denotes	data
T4428	20194-20205	JJ	denotes	unpublished
T4429	20210-20211	-RRB-	denotes	)
T4430	20211-20212	.	denotes	.
T4431	20212-20344	sentence	denotes	Normal Alcian blue staining was seen in non-articular regions, such as the cartilaginous growth plate (Figure 3D and 3E, asterisk).
T4432	20213-20219	JJ	denotes	Normal
T4433	20232-20240	NN	denotes	staining
T4434	20220-20226	JJ	denotes	Alcian
T4435	20227-20231	NN	denotes	blue
T4436	20245-20249	VBN	denotes	seen
T4437	20241-20244	VBD	denotes	was
T4438	20250-20252	IN	denotes	in
T4439	20253-20266	JJ	denotes	non-articular
T4440	20267-20274	NNS	denotes	regions
T4441	20274-20276	,	denotes	,
T4442	20276-20280	JJ	denotes	such
T4443	20281-20283	IN	denotes	as
T4444	20284-20287	DT	denotes	the
T4445	20309-20314	NN	denotes	plate
T4446	20288-20301	JJ	denotes	cartilaginous
T4447	20302-20308	NN	denotes	growth
T4448	20315-20316	-LRB-	denotes	(
T4449	20334-20342	NN	denotes	asterisk
T4450	20316-20322	NN	denotes	Figure
T4451	20323-20325	CD	denotes	3D
T4452	20326-20329	CC	denotes	and
T4453	20330-20332	CD	denotes	3E
T4454	20332-20334	,	denotes	,
T4455	20342-20343	-RRB-	denotes	)
T4456	20343-20344	.	denotes	.
T4457	20344-20551	sentence	denotes	These data suggest that Bmpr1a function is required for the formation of specific joints in the ankle region and for either generation or maintenance of articular cartilage in most other joints of the limb.
T4458	20345-20350	DT	denotes	These
T4459	20351-20355	NNS	denotes	data
T4460	20356-20363	VBP	denotes	suggest
T4461	20364-20368	IN	denotes	that
T4462	20385-20387	VBZ	denotes	is
T4463	20369-20375	NN	denotes	Bmpr1a
T4464	20376-20384	NN	denotes	function
T4465	20388-20396	VBN	denotes	required
T4466	20397-20400	IN	denotes	for
T4467	20401-20404	DT	denotes	the
T4468	20405-20414	NN	denotes	formation
T4469	20415-20417	IN	denotes	of
T4470	20418-20426	JJ	denotes	specific
T4471	20427-20433	NNS	denotes	joints
T4472	20434-20436	IN	denotes	in
T4473	20437-20440	DT	denotes	the
T4474	20447-20453	NN	denotes	region
T4475	20441-20446	NN	denotes	ankle
T4476	20454-20457	CC	denotes	and
T4477	20458-20461	IN	denotes	for
T4478	20462-20468	CC	denotes	either
T4479	20469-20479	NN	denotes	generation
T4480	20480-20482	CC	denotes	or
T4481	20483-20494	NN	denotes	maintenance
T4482	20495-20497	IN	denotes	of
T4483	20498-20507	JJ	denotes	articular
T4484	20508-20517	NN	denotes	cartilage
T4485	20518-20520	IN	denotes	in
T4486	20521-20525	JJS	denotes	most
T4487	20532-20538	NNS	denotes	joints
T4488	20526-20531	JJ	denotes	other
T4489	20539-20541	IN	denotes	of
T4490	20542-20545	DT	denotes	the
T4491	20546-20550	NN	denotes	limb
T4492	20550-20551	.	denotes	.
T4677	20553-20566	JJ	denotes	Developmental
T4678	20567-20573	NN	denotes	Origin
T4679	20574-20576	IN	denotes	of
T4680	20577-20584	NN	denotes	Webbing
T4681	20585-20594	NN	denotes	Phenotype
T4682	20594-20911	sentence	denotes	Interdigital mesenchyme is normally eliminated by apoptosis during embryonic development, a process that can be stimulated by BMP beads, inhibited by Noggin, or blocked by overexpression of dominant-negative BMP receptors (Garcia-Martinez et al. 1993; Yokouchi et al. 1996; Zou and Niswander 1996; Guha et al. 2002).
T4683	20595-20607	JJ	denotes	Interdigital
T4684	20608-20618	NN	denotes	mesenchyme
T4685	20631-20641	VBN	denotes	eliminated
T4686	20619-20621	VBZ	denotes	is
T4687	20622-20630	RB	denotes	normally
T4688	20642-20644	IN	denotes	by
T4689	20645-20654	NN	denotes	apoptosis
T4690	20655-20661	IN	denotes	during
T4691	20662-20671	JJ	denotes	embryonic
T4692	20672-20683	NN	denotes	development
T4693	20683-20685	,	denotes	,
T4694	20685-20686	DT	denotes	a
T4695	20687-20694	NN	denotes	process
T4696	20695-20699	WDT	denotes	that
T4697	20707-20717	VBN	denotes	stimulated
T4698	20700-20703	MD	denotes	can
T4699	20704-20706	VB	denotes	be
T4700	20718-20720	IN	denotes	by
T4701	20721-20724	NN	denotes	BMP
T4702	20725-20730	NNS	denotes	beads
T4703	20730-20732	,	denotes	,
T4704	20732-20741	VBN	denotes	inhibited
T4705	20742-20744	IN	denotes	by
T4706	20745-20751	NN	denotes	Noggin
T4707	20751-20753	,	denotes	,
T4708	20753-20755	CC	denotes	or
T4709	20756-20763	VBN	denotes	blocked
T4710	20764-20766	IN	denotes	by
T4711	20767-20781	NN	denotes	overexpression
T4712	20782-20784	IN	denotes	of
T4713	20785-20793	JJ	denotes	dominant
T4714	20794-20802	JJ	denotes	negative
T4715	20793-20794	HYPH	denotes	-
T4716	20807-20816	NNS	denotes	receptors
T4717	20803-20806	NN	denotes	BMP
T4718	20817-20818	-LRB-	denotes	(
T4719	20818-20824	NNP	denotes	Garcia
T4720	20824-20825	HYPH	denotes	-
T4721	20825-20833	NNP	denotes	Martinez
T4722	20834-20836	FW	denotes	et
T4723	20837-20840	FW	denotes	al.
T4724	20841-20845	CD	denotes	1993
T4725	20845-20846	:	denotes	;
T4726	20847-20855	NNP	denotes	Yokouchi
T4727	20856-20858	FW	denotes	et
T4728	20859-20862	FW	denotes	al.
T4729	20863-20867	CD	denotes	1996
T4730	20867-20868	:	denotes	;
T4731	20869-20872	NNP	denotes	Zou
T4732	20873-20876	CC	denotes	and
T4733	20877-20886	NNP	denotes	Niswander
T4734	20887-20891	CD	denotes	1996
T4735	20891-20892	:	denotes	;
T4736	20893-20897	NNP	denotes	Guha
T4737	20898-20900	FW	denotes	et
T4738	20901-20904	FW	denotes	al.
T4739	20905-20909	CD	denotes	2002
T4740	20909-20910	-RRB-	denotes	)
T4741	20910-20911	.	denotes	.
T4742	20911-21185	sentence	denotes	Limbs of Gdf5-Cre/Bmpr1afloxP mutant embryos showed obvious retention of interdigital webbing between the first and second, but not other, digits of E14.5 forelimbs (Figure 2A and 2B), a pattern that corresponds to the presence or absence of webbing seen in the adult limb.
T4743	20912-20917	NNS	denotes	Limbs
T4744	20957-20963	VBD	denotes	showed
T4745	20918-20920	IN	denotes	of
T4746	20921-20925	NN	denotes	Gdf5
T4747	20926-20929	NN	denotes	Cre
T4748	20925-20926	HYPH	denotes	-
T4749	20930-20941	NN	denotes	Bmpr1afloxP
T4750	20929-20930	HYPH	denotes	/
T4751	20942-20948	JJ	denotes	mutant
T4752	20949-20956	NNS	denotes	embryos
T4753	20964-20971	JJ	denotes	obvious
T4754	20972-20981	NN	denotes	retention
T4755	20982-20984	IN	denotes	of
T4756	20985-20997	JJ	denotes	interdigital
T4757	20998-21005	NN	denotes	webbing
T4758	21006-21013	IN	denotes	between
T4759	21014-21017	DT	denotes	the
T4760	21051-21057	NNS	denotes	digits
T4761	21018-21023	JJ	denotes	first
T4762	21024-21027	CC	denotes	and
T4763	21028-21034	JJ	denotes	second
T4764	21034-21036	,	denotes	,
T4765	21036-21039	CC	denotes	but
T4766	21040-21043	RB	denotes	not
T4767	21044-21049	JJ	denotes	other
T4768	21049-21051	,	denotes	,
T4769	21058-21060	IN	denotes	of
T4770	21061-21066	NN	denotes	E14.5
T4771	21067-21076	NNS	denotes	forelimbs
T4772	21077-21078	-LRB-	denotes	(
T4773	21078-21084	NN	denotes	Figure
T4774	21085-21087	CD	denotes	2A
T4775	21088-21091	CC	denotes	and
T4776	21092-21094	CD	denotes	2B
T4777	21094-21095	-RRB-	denotes	)
T4778	21095-21097	,	denotes	,
T4779	21097-21098	DT	denotes	a
T4780	21099-21106	NN	denotes	pattern
T4781	21107-21111	WDT	denotes	that
T4782	21112-21123	VBZ	denotes	corresponds
T4783	21124-21126	IN	denotes	to
T4784	21127-21130	DT	denotes	the
T4785	21131-21139	NN	denotes	presence
T4786	21140-21142	CC	denotes	or
T4787	21143-21150	NN	denotes	absence
T4788	21151-21153	IN	denotes	of
T4789	21154-21161	NN	denotes	webbing
T4790	21162-21166	VBN	denotes	seen
T4791	21167-21169	IN	denotes	in
T4792	21170-21173	DT	denotes	the
T4793	21180-21184	NN	denotes	limb
T4794	21174-21179	NN	denotes	adult
T4795	21184-21185	.	denotes	.
T4796	21185-21279	sentence	denotes	They also showed excess tissue on the posterior margin of the fifth digit (Figure 2B, arrow).
T4797	21186-21190	PRP	denotes	They
T4798	21196-21202	VBD	denotes	showed
T4799	21191-21195	RB	denotes	also
T4800	21203-21209	JJ	denotes	excess
T4801	21210-21216	NN	denotes	tissue
T4802	21217-21219	IN	denotes	on
T4803	21220-21223	DT	denotes	the
T4804	21234-21240	NN	denotes	margin
T4805	21224-21233	JJ	denotes	posterior
T4806	21241-21243	IN	denotes	of
T4807	21244-21247	DT	denotes	the
T4808	21254-21259	NN	denotes	digit
T4809	21248-21253	JJ	denotes	fifth
T4810	21260-21261	-LRB-	denotes	(
T4811	21272-21277	NN	denotes	arrow
T4812	21261-21267	NN	denotes	Figure
T4813	21268-21270	CD	denotes	2B
T4814	21270-21272	,	denotes	,
T4815	21277-21278	-RRB-	denotes	)
T4816	21278-21279	.	denotes	.
T4817	21279-21523	sentence	denotes	Analysis of LACZ expression in Gdf5-Cre/R26R reporter embryos showed that Cre-mediated recombination has occurred by E13.5 in the metacarpal-phalangeal joints, and in the interdigital region between the first and second, but not other, digits.
T4818	21280-21288	NN	denotes	Analysis
T4819	21342-21348	VBD	denotes	showed
T4820	21289-21291	IN	denotes	of
T4821	21292-21296	NN	denotes	LACZ
T4822	21297-21307	NN	denotes	expression
T4823	21308-21310	IN	denotes	in
T4824	21311-21315	NN	denotes	Gdf5
T4825	21316-21319	NN	denotes	Cre
T4826	21315-21316	HYPH	denotes	-
T4827	21320-21324	NN	denotes	R26R
T4828	21319-21320	HYPH	denotes	/
T4829	21334-21341	NNS	denotes	embryos
T4830	21325-21333	NN	denotes	reporter
T4831	21349-21353	IN	denotes	that
T4832	21385-21393	VBN	denotes	occurred
T4833	21354-21357	NN	denotes	Cre
T4834	21358-21366	VBN	denotes	mediated
T4835	21357-21358	HYPH	denotes	-
T4836	21367-21380	NN	denotes	recombination
T4837	21381-21384	VBZ	denotes	has
T4838	21394-21396	IN	denotes	by
T4839	21397-21402	NN	denotes	E13.5
T4840	21403-21405	IN	denotes	in
T4841	21406-21409	DT	denotes	the
T4842	21432-21438	NNS	denotes	joints
T4843	21410-21420	JJ	denotes	metacarpal
T4844	21421-21431	JJ	denotes	phalangeal
T4845	21420-21421	HYPH	denotes	-
T4846	21438-21440	,	denotes	,
T4847	21440-21443	CC	denotes	and
T4848	21444-21446	IN	denotes	in
T4849	21447-21450	DT	denotes	the
T4850	21464-21470	NN	denotes	region
T4851	21451-21463	JJ	denotes	interdigital
T4852	21471-21478	IN	denotes	between
T4853	21479-21482	DT	denotes	the
T4854	21516-21522	NNS	denotes	digits
T4855	21483-21488	JJ	denotes	first
T4856	21489-21492	CC	denotes	and
T4857	21493-21499	JJ	denotes	second
T4858	21499-21501	,	denotes	,
T4859	21501-21504	CC	denotes	but
T4860	21505-21508	RB	denotes	not
T4861	21509-21514	JJ	denotes	other
T4862	21514-21516	,	denotes	,
T4863	21522-21523	.	denotes	.
T4864	21523-21665	sentence	denotes	In addition, a domain of recombination and expression of LACZ is also reproducibly seen in the posterior half of the fifth digit (Figure 2C).
T4865	21524-21526	IN	denotes	In
T4866	21607-21611	VBN	denotes	seen
T4867	21527-21535	NN	denotes	addition
T4868	21535-21537	,	denotes	,
T4869	21537-21538	DT	denotes	a
T4870	21539-21545	NN	denotes	domain
T4871	21546-21548	IN	denotes	of
T4872	21549-21562	NN	denotes	recombination
T4873	21563-21566	CC	denotes	and
T4874	21567-21577	NN	denotes	expression
T4875	21578-21580	IN	denotes	of
T4876	21581-21585	NN	denotes	LACZ
T4877	21586-21588	VBZ	denotes	is
T4878	21589-21593	RB	denotes	also
T4879	21594-21606	RB	denotes	reproducibly
T4880	21612-21614	IN	denotes	in
T4881	21615-21618	DT	denotes	the
T4882	21629-21633	NN	denotes	half
T4883	21619-21628	JJ	denotes	posterior
T4884	21634-21636	IN	denotes	of
T4885	21637-21640	DT	denotes	the
T4886	21647-21652	NN	denotes	digit
T4887	21641-21646	JJ	denotes	fifth
T4888	21653-21654	-LRB-	denotes	(
T4889	21654-21660	NN	denotes	Figure
T4890	21661-21663	CD	denotes	2C
T4891	21663-21664	-RRB-	denotes	)
T4892	21664-21665	.	denotes	.
T4893	21665-22004	sentence	denotes	Terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of interdigital mesenchyme between the first and second digits (Figure 2D and 2E) and the fifth digit flanking mesenchyme showed a decreased number of dying cells in the regions where excess tissue is retained in the mutant limbs.
T4894	21666-21674	JJ	denotes	Terminal
T4895	21748-21756	NN	denotes	labeling
T4896	21675-21691	NN	denotes	deoxynucleotidyl
T4897	21692-21703	NN	denotes	transferase
T4898	21704-21712	VBN	denotes	mediated
T4899	21703-21704	HYPH	denotes	–
T4900	21713-21725	NN	denotes	deoxyuridine
T4901	21726-21738	NN	denotes	triphosphate
T4902	21739-21743	NN	denotes	nick
T4903	21744-21747	NN	denotes	end
T4904	21765-21773	NN	denotes	staining
T4905	21757-21758	-LRB-	denotes	(
T4906	21758-21763	NN	denotes	TUNEL
T4907	21763-21764	-RRB-	denotes	)
T4908	21896-21902	VBD	denotes	showed
T4909	21774-21776	IN	denotes	of
T4910	21777-21789	JJ	denotes	interdigital
T4911	21790-21800	NN	denotes	mesenchyme
T4912	21801-21808	IN	denotes	between
T4913	21809-21812	DT	denotes	the
T4914	21830-21836	NNS	denotes	digits
T4915	21813-21818	JJ	denotes	first
T4916	21819-21822	CC	denotes	and
T4917	21823-21829	JJ	denotes	second
T4918	21837-21838	-LRB-	denotes	(
T4919	21838-21844	NN	denotes	Figure
T4920	21845-21847	CD	denotes	2D
T4921	21848-21851	CC	denotes	and
T4922	21852-21854	CD	denotes	2E
T4923	21854-21855	-RRB-	denotes	)
T4924	21856-21859	CC	denotes	and
T4925	21860-21863	DT	denotes	the
T4926	21870-21875	NN	denotes	digit
T4927	21864-21869	JJ	denotes	fifth
T4928	21876-21884	VBG	denotes	flanking
T4929	21885-21895	NN	denotes	mesenchyme
T4930	21903-21904	DT	denotes	a
T4931	21915-21921	NN	denotes	number
T4932	21905-21914	VBN	denotes	decreased
T4933	21922-21924	IN	denotes	of
T4934	21925-21930	VBG	denotes	dying
T4935	21931-21936	NNS	denotes	cells
T4936	21937-21939	IN	denotes	in
T4937	21940-21943	DT	denotes	the
T4938	21944-21951	NNS	denotes	regions
T4939	21952-21957	WRB	denotes	where
T4940	21975-21983	VBN	denotes	retained
T4941	21958-21964	JJ	denotes	excess
T4942	21965-21971	NN	denotes	tissue
T4943	21972-21974	VBZ	denotes	is
T4944	21984-21986	IN	denotes	in
T4945	21987-21990	DT	denotes	the
T4946	21998-22003	NNS	denotes	limbs
T4947	21991-21997	NN	denotes	mutant
T4948	22003-22004	.	denotes	.
T4949	22004-22118	sentence	denotes	Numbers of phosphorylated histone H3-labeled proliferating cells were also elevated in these regions (Figure 2F).
T4950	22005-22012	NNS	denotes	Numbers
T4951	22080-22088	VBN	denotes	elevated
T4952	22013-22015	IN	denotes	of
T4953	22016-22030	VBN	denotes	phosphorylated
T4954	22039-22041	NN	denotes	H3
T4955	22031-22038	NN	denotes	histone
T4956	22042-22049	VBN	denotes	labeled
T4957	22041-22042	HYPH	denotes	-
T4958	22064-22069	NNS	denotes	cells
T4959	22050-22063	VBG	denotes	proliferating
T4960	22070-22074	VBD	denotes	were
T4961	22075-22079	RB	denotes	also
T4962	22089-22091	IN	denotes	in
T4963	22092-22097	DT	denotes	these
T4964	22098-22105	NNS	denotes	regions
T4965	22106-22107	-LRB-	denotes	(
T4966	22107-22113	NN	denotes	Figure
T4967	22114-22116	CD	denotes	2F
T4968	22116-22117	-RRB-	denotes	)
T4969	22117-22118	.	denotes	.
T4970	22118-22277	sentence	denotes	Most cells found in the webbed region between the first and second digits at E15.5 strongly expressed LACZ in Gdf5-Cre/Bmpr1afloxP mutant embryos (Figure 2H).
T4971	22119-22123	JJS	denotes	Most
T4972	22124-22129	NNS	denotes	cells
T4973	22211-22220	VBD	denotes	expressed
T4974	22130-22135	VBN	denotes	found
T4975	22136-22138	IN	denotes	in
T4976	22139-22142	DT	denotes	the
T4977	22150-22156	NN	denotes	region
T4978	22143-22149	VBN	denotes	webbed
T4979	22157-22164	IN	denotes	between
T4980	22165-22168	DT	denotes	the
T4981	22186-22192	NNS	denotes	digits
T4982	22169-22174	JJ	denotes	first
T4983	22175-22178	CC	denotes	and
T4984	22179-22185	JJ	denotes	second
T4985	22193-22195	IN	denotes	at
T4986	22196-22201	NN	denotes	E15.5
T4987	22202-22210	RB	denotes	strongly
T4988	22221-22225	NN	denotes	LACZ
T4989	22226-22228	IN	denotes	in
T4990	22229-22233	NN	denotes	Gdf5
T4991	22234-22237	NN	denotes	Cre
T4992	22233-22234	HYPH	denotes	-
T4993	22238-22249	NN	denotes	Bmpr1afloxP
T4994	22237-22238	HYPH	denotes	/
T4995	22257-22264	NNS	denotes	embryos
T4996	22250-22256	NN	denotes	mutant
T4997	22265-22266	-LRB-	denotes	(
T4998	22266-22272	NN	denotes	Figure
T4999	22273-22275	CD	denotes	2H
T5000	22275-22276	-RRB-	denotes	)
T5001	22276-22277	.	denotes	.
T5002	22277-22491	sentence	denotes	These data suggest that regional loss of BMPR1A receptor signaling blocks programmed cell death in interdigital mesenchyme, and that the recombined cells survive and proliferate in the absence of BMPR1A signaling.
T5003	22278-22283	DT	denotes	These
T5004	22284-22288	NNS	denotes	data
T5005	22289-22296	VBP	denotes	suggest
T5006	22297-22301	IN	denotes	that
T5007	22345-22351	VBZ	denotes	blocks
T5008	22302-22310	JJ	denotes	regional
T5009	22311-22315	NN	denotes	loss
T5010	22316-22318	IN	denotes	of
T5011	22319-22325	NN	denotes	BMPR1A
T5012	22335-22344	NN	denotes	signaling
T5013	22326-22334	NN	denotes	receptor
T5014	22352-22362	VBN	denotes	programmed
T5015	22368-22373	NN	denotes	death
T5016	22363-22367	NN	denotes	cell
T5017	22374-22376	IN	denotes	in
T5018	22377-22389	JJ	denotes	interdigital
T5019	22390-22400	NN	denotes	mesenchyme
T5020	22400-22402	,	denotes	,
T5021	22402-22405	CC	denotes	and
T5022	22406-22410	IN	denotes	that
T5023	22432-22439	VBP	denotes	survive
T5024	22411-22414	DT	denotes	the
T5025	22426-22431	NNS	denotes	cells
T5026	22415-22425	VBN	denotes	recombined
T5027	22440-22443	CC	denotes	and
T5028	22444-22455	VBP	denotes	proliferate
T5029	22456-22458	IN	denotes	in
T5030	22459-22462	DT	denotes	the
T5031	22463-22470	NN	denotes	absence
T5032	22471-22473	IN	denotes	of
T5033	22474-22480	NN	denotes	BMPR1A
T5034	22481-22490	NN	denotes	signaling
T5035	22490-22491	.	denotes	.
T5185	22644-22645	.	denotes	.
T5186	22645-22821	sentence	denotes	In situ hybridization showed that the gene is also expressed in the interzones of ankle joints and prospective articular cartilage regions of digit joints at E15.5 (Figure 4).
T5187	22646-22648	FW	denotes	In
T5188	22649-22653	FW	denotes	situ
T5189	22654-22667	NN	denotes	hybridization
T5190	22668-22674	VBD	denotes	showed
T5191	22675-22679	IN	denotes	that
T5192	22697-22706	VBN	denotes	expressed
T5193	22680-22683	DT	denotes	the
T5194	22684-22688	NN	denotes	gene
T5195	22689-22691	VBZ	denotes	is
T5196	22692-22696	RB	denotes	also
T5197	22707-22709	IN	denotes	in
T5198	22710-22713	DT	denotes	the
T5199	22714-22724	NNS	denotes	interzones
T5200	22725-22727	IN	denotes	of
T5201	22728-22733	NN	denotes	ankle
T5202	22734-22740	NNS	denotes	joints
T5203	22741-22744	CC	denotes	and
T5204	22745-22756	JJ	denotes	prospective
T5205	22777-22784	NNS	denotes	regions
T5206	22757-22766	JJ	denotes	articular
T5207	22767-22776	NN	denotes	cartilage
T5208	22785-22787	IN	denotes	of
T5209	22788-22793	NN	denotes	digit
T5210	22794-22800	NNS	denotes	joints
T5211	22801-22803	IN	denotes	at
T5212	22804-22809	NN	denotes	E15.5
T5213	22810-22811	-LRB-	denotes	(
T5214	22811-22817	NN	denotes	Figure
T5215	22818-22819	CD	denotes	4
T5216	22819-22820	-RRB-	denotes	)
T5217	22820-22821	.	denotes	.
T5218	22821-22988	sentence	denotes	LACZ staining indicated that Cre-mediated recombination begins to occur in ankle joints around E14.5, and is extensive by E15.5 (Figure 4G and 4J) (unpublished data).
T5219	22822-22826	NN	denotes	LACZ
T5220	22827-22835	NN	denotes	staining
T5221	22836-22845	VBD	denotes	indicated
T5222	22846-22850	IN	denotes	that
T5223	22878-22884	VBZ	denotes	begins
T5224	22851-22854	NN	denotes	Cre
T5225	22855-22863	VBN	denotes	mediated
T5226	22854-22855	HYPH	denotes	-
T5227	22864-22877	NN	denotes	recombination
T5228	22885-22887	TO	denotes	to
T5229	22888-22893	VB	denotes	occur
T5230	22894-22896	IN	denotes	in
T5231	22897-22902	NN	denotes	ankle
T5232	22903-22909	NNS	denotes	joints
T5233	22910-22916	IN	denotes	around
T5234	22917-22922	NN	denotes	E14.5
T5235	22922-22924	,	denotes	,
T5236	22924-22927	CC	denotes	and
T5237	22928-22930	VBZ	denotes	is
T5238	22931-22940	JJ	denotes	extensive
T5239	22941-22943	IN	denotes	by
T5240	22944-22949	NN	denotes	E15.5
T5241	22950-22951	-LRB-	denotes	(
T5242	22951-22957	NN	denotes	Figure
T5243	22958-22960	CD	denotes	4G
T5244	22961-22964	CC	denotes	and
T5245	22965-22967	CD	denotes	4J
T5246	22967-22968	-RRB-	denotes	)
T5247	22969-22970	-LRB-	denotes	(
T5248	22982-22986	NNS	denotes	data
T5249	22970-22981	JJ	denotes	unpublished
T5250	22986-22987	-RRB-	denotes	)
T5251	22987-22988	.	denotes	.
T5252	22988-23144	sentence	denotes	In the ankle joint regions that were obviously fused in postnatal mutant animals, alterations in early joint marker expression could also be seen by E15.5.
T5253	22989-22991	IN	denotes	In
T5254	23130-23134	VBN	denotes	seen
T5255	22992-22995	DT	denotes	the
T5256	23008-23015	NNS	denotes	regions
T5257	22996-23001	NN	denotes	ankle
T5258	23002-23007	NN	denotes	joint
T5259	23016-23020	WDT	denotes	that
T5260	23036-23041	VBN	denotes	fused
T5261	23021-23025	VBD	denotes	were
T5262	23026-23035	RB	denotes	obviously
T5263	23042-23044	IN	denotes	in
T5264	23045-23054	JJ	denotes	postnatal
T5265	23062-23069	NNS	denotes	animals
T5266	23055-23061	NN	denotes	mutant
T5267	23069-23071	,	denotes	,
T5268	23071-23082	NNS	denotes	alterations
T5269	23083-23085	IN	denotes	in
T5270	23086-23091	JJ	denotes	early
T5271	23105-23115	NN	denotes	expression
T5272	23092-23097	NN	denotes	joint
T5273	23098-23104	NN	denotes	marker
T5274	23116-23121	MD	denotes	could
T5275	23122-23126	RB	denotes	also
T5276	23127-23129	VB	denotes	be
T5277	23135-23137	IN	denotes	by
T5278	23138-23143	NN	denotes	E15.5
T5279	23143-23144	.	denotes	.
T5280	23144-23386	sentence	denotes	At this stage, the Gdf5 gene is normally expressed in stripes that mark the sites of joint formation (Figure 4F), and the gene for the major collagen protein of cartilage matrix (Col2a1) is down-regulated in the interzone region (Figure 4E).
T5281	23145-23147	IN	denotes	At
T5282	23186-23195	VBN	denotes	expressed
T5283	23148-23152	DT	denotes	this
T5284	23153-23158	NN	denotes	stage
T5285	23158-23160	,	denotes	,
T5286	23160-23163	DT	denotes	the
T5287	23169-23173	NN	denotes	gene
T5288	23164-23168	NN	denotes	Gdf5
T5289	23174-23176	VBZ	denotes	is
T5290	23177-23185	RB	denotes	normally
T5291	23196-23198	IN	denotes	in
T5292	23199-23206	NNS	denotes	stripes
T5293	23207-23211	WDT	denotes	that
T5294	23212-23216	VBP	denotes	mark
T5295	23217-23220	DT	denotes	the
T5296	23221-23226	NNS	denotes	sites
T5297	23227-23229	IN	denotes	of
T5298	23230-23235	NN	denotes	joint
T5299	23236-23245	NN	denotes	formation
T5300	23246-23247	-LRB-	denotes	(
T5301	23247-23253	NN	denotes	Figure
T5302	23254-23256	CD	denotes	4F
T5303	23256-23257	-RRB-	denotes	)
T5304	23257-23259	,	denotes	,
T5305	23259-23262	CC	denotes	and
T5306	23263-23266	DT	denotes	the
T5307	23267-23271	NN	denotes	gene
T5308	23340-23349	VBN	denotes	regulated
T5309	23272-23275	IN	denotes	for
T5310	23276-23279	DT	denotes	the
T5311	23295-23302	NN	denotes	protein
T5312	23280-23285	JJ	denotes	major
T5313	23286-23294	NN	denotes	collagen
T5314	23303-23305	IN	denotes	of
T5315	23306-23315	NN	denotes	cartilage
T5316	23316-23322	NN	denotes	matrix
T5317	23323-23324	-LRB-	denotes	(
T5318	23324-23330	NN	denotes	Col2a1
T5319	23330-23331	-RRB-	denotes	)
T5320	23332-23334	VBZ	denotes	is
T5321	23335-23339	RB	denotes	down
T5322	23339-23340	HYPH	denotes	-
T5323	23350-23352	IN	denotes	in
T5324	23353-23356	DT	denotes	the
T5325	23367-23373	NN	denotes	region
T5326	23357-23366	NN	denotes	interzone
T5327	23374-23375	-LRB-	denotes	(
T5328	23375-23381	NN	denotes	Figure
T5329	23382-23384	CD	denotes	4E
T5330	23384-23385	-RRB-	denotes	)
T5331	23385-23386	.	denotes	.
T5332	23386-23678	sentence	denotes	In contrast, Col2a1 staining extended completely through the joint region between the second and central tarsal of Gdf5-Cre/Bmpr1afloxP mutants (Figure 4H, black arrow), and Gdf5 expression was seen only as a small notch extending into where the joint should be forming (Figure 4I, bracket).
T5333	23387-23389	IN	denotes	In
T5334	23416-23424	VBD	denotes	extended
T5335	23390-23398	NN	denotes	contrast
T5336	23398-23400	,	denotes	,
T5337	23400-23406	NN	denotes	Col2a1
T5338	23407-23415	NN	denotes	staining
T5339	23425-23435	RB	denotes	completely
T5340	23436-23443	IN	denotes	through
T5341	23444-23447	DT	denotes	the
T5342	23454-23460	NN	denotes	region
T5343	23448-23453	NN	denotes	joint
T5344	23461-23468	IN	denotes	between
T5345	23469-23472	DT	denotes	the
T5346	23492-23498	NN	denotes	tarsal
T5347	23473-23479	JJ	denotes	second
T5348	23480-23483	CC	denotes	and
T5349	23484-23491	JJ	denotes	central
T5350	23499-23501	IN	denotes	of
T5351	23502-23506	NN	denotes	Gdf5
T5352	23507-23510	NN	denotes	Cre
T5353	23506-23507	HYPH	denotes	-
T5354	23511-23522	NN	denotes	Bmpr1afloxP
T5355	23510-23511	HYPH	denotes	/
T5356	23523-23530	NNS	denotes	mutants
T5357	23531-23532	-LRB-	denotes	(
T5358	23549-23554	NN	denotes	arrow
T5359	23532-23538	NN	denotes	Figure
T5360	23539-23541	CD	denotes	4H
T5361	23541-23543	,	denotes	,
T5362	23543-23548	JJ	denotes	black
T5363	23554-23555	-RRB-	denotes	)
T5364	23555-23557	,	denotes	,
T5365	23557-23560	CC	denotes	and
T5366	23561-23565	NN	denotes	Gdf5
T5367	23566-23576	NN	denotes	expression
T5368	23581-23585	VBN	denotes	seen
T5369	23577-23580	VBD	denotes	was
T5370	23586-23590	RB	denotes	only
T5371	23591-23593	IN	denotes	as
T5372	23594-23595	DT	denotes	a
T5373	23602-23607	NN	denotes	notch
T5374	23596-23601	JJ	denotes	small
T5375	23608-23617	VBG	denotes	extending
T5376	23618-23622	IN	denotes	into
T5377	23623-23628	WRB	denotes	where
T5378	23649-23656	VBG	denotes	forming
T5379	23629-23632	DT	denotes	the
T5380	23633-23638	NN	denotes	joint
T5381	23639-23645	MD	denotes	should
T5382	23646-23648	VB	denotes	be
T5383	23657-23658	-LRB-	denotes	(
T5384	23669-23676	NN	denotes	bracket
T5385	23658-23664	NN	denotes	Figure
T5386	23665-23667	CD	denotes	4I
T5387	23667-23669	,	denotes	,
T5388	23676-23677	-RRB-	denotes	)
T5389	23677-23678	.	denotes	.
T5390	23678-23914	sentence	denotes	These data suggest that the fusions seen between ankle bones in postnatal mutant skeletons are the result of incomplete segmentation of skeletal precursors during embryonic development, a defect confined to some locations in the ankle.
T5391	23679-23684	DT	denotes	These
T5392	23685-23689	NNS	denotes	data
T5393	23690-23697	VBP	denotes	suggest
T5394	23698-23702	IN	denotes	that
T5395	23770-23773	VBP	denotes	are
T5396	23703-23706	DT	denotes	the
T5397	23707-23714	NNS	denotes	fusions
T5398	23715-23719	VBN	denotes	seen
T5399	23720-23727	IN	denotes	between
T5400	23728-23733	NN	denotes	ankle
T5401	23734-23739	NNS	denotes	bones
T5402	23740-23742	IN	denotes	in
T5403	23743-23752	JJ	denotes	postnatal
T5404	23760-23769	NNS	denotes	skeletons
T5405	23753-23759	NN	denotes	mutant
T5406	23774-23777	DT	denotes	the
T5407	23778-23784	NN	denotes	result
T5408	23785-23787	IN	denotes	of
T5409	23788-23798	JJ	denotes	incomplete
T5410	23799-23811	NN	denotes	segmentation
T5411	23812-23814	IN	denotes	of
T5412	23815-23823	JJ	denotes	skeletal
T5413	23824-23834	NNS	denotes	precursors
T5414	23835-23841	IN	denotes	during
T5415	23842-23851	JJ	denotes	embryonic
T5416	23852-23863	NN	denotes	development
T5417	23863-23865	,	denotes	,
T5418	23865-23866	DT	denotes	a
T5419	23867-23873	NN	denotes	defect
T5420	23874-23882	VBN	denotes	confined
T5421	23883-23885	IN	denotes	to
T5422	23886-23890	DT	denotes	some
T5423	23891-23900	NNS	denotes	locations
T5424	23901-23903	IN	denotes	in
T5425	23904-23907	DT	denotes	the
T5426	23908-23913	NN	denotes	ankle
T5427	23913-23914	.	denotes	.
T5886	25410-25417	NN	denotes	Failure
T5887	25418-25420	TO	denotes	to
T5888	25421-25429	VB	denotes	Maintain
T5889	25430-25439	JJ	denotes	Articular
T5890	25440-25449	NN	denotes	Cartilage
T5891	25450-25452	IN	denotes	in
T5892	25453-25458	JJ	denotes	Other
T5893	25459-25465	NNS	denotes	Joints
T5894	25465-25582	sentence	denotes	In most joints of Bmpr1a conditional knockout mice, embryonic segmentation of skeletal precursors occurred normally.
T5895	25466-25468	IN	denotes	In
T5896	25564-25572	VBD	denotes	occurred
T5897	25469-25473	JJS	denotes	most
T5898	25474-25480	NNS	denotes	joints
T5899	25481-25483	IN	denotes	of
T5900	25484-25490	NN	denotes	Bmpr1a
T5901	25503-25511	NN	denotes	knockout
T5902	25491-25502	JJ	denotes	conditional
T5903	25512-25516	NNS	denotes	mice
T5904	25516-25518	,	denotes	,
T5905	25518-25527	JJ	denotes	embryonic
T5906	25528-25540	NN	denotes	segmentation
T5907	25541-25543	IN	denotes	of
T5908	25544-25552	JJ	denotes	skeletal
T5909	25553-25563	NNS	denotes	precursors
T5910	25573-25581	RB	denotes	normally
T5911	25581-25582	.	denotes	.
T5912	25582-25854	sentence	denotes	Although Gdf5-Cre-mediated recombination was seen as early as E13.5 in digit interzone regions (see Figure 2C), no changes in cell death or cell proliferation could be seen in the metacarpal-phalangeal or metatarsal-phalangeal joints at E13.5 or E14.5 (unpublished data).
T5913	25583-25591	IN	denotes	Although
T5914	25628-25632	VBN	denotes	seen
T5915	25592-25596	NN	denotes	Gdf5
T5916	25597-25600	NN	denotes	Cre
T5917	25596-25597	HYPH	denotes	-
T5918	25601-25609	VBN	denotes	mediated
T5919	25600-25601	HYPH	denotes	-
T5920	25610-25623	NN	denotes	recombination
T5921	25624-25627	VBD	denotes	was
T5922	25751-25755	VBN	denotes	seen
T5923	25633-25635	RB	denotes	as
T5924	25636-25641	RB	denotes	early
T5925	25642-25644	IN	denotes	as
T5926	25645-25650	NN	denotes	E13.5
T5927	25651-25653	IN	denotes	in
T5928	25654-25659	NN	denotes	digit
T5929	25670-25677	NNS	denotes	regions
T5930	25660-25669	NN	denotes	interzone
T5931	25678-25679	-LRB-	denotes	(
T5932	25679-25682	VB	denotes	see
T5933	25683-25689	NN	denotes	Figure
T5934	25690-25692	CD	denotes	2C
T5935	25692-25693	-RRB-	denotes	)
T5936	25693-25695	,	denotes	,
T5937	25695-25697	DT	denotes	no
T5938	25698-25705	NNS	denotes	changes
T5939	25706-25708	IN	denotes	in
T5940	25709-25713	NN	denotes	cell
T5941	25714-25719	NN	denotes	death
T5942	25720-25722	CC	denotes	or
T5943	25723-25727	NN	denotes	cell
T5944	25728-25741	NN	denotes	proliferation
T5945	25742-25747	MD	denotes	could
T5946	25748-25750	VB	denotes	be
T5947	25756-25758	IN	denotes	in
T5948	25759-25762	DT	denotes	the
T5949	25810-25816	NNS	denotes	joints
T5950	25763-25773	JJ	denotes	metacarpal
T5951	25774-25784	JJ	denotes	phalangeal
T5952	25773-25774	HYPH	denotes	-
T5953	25785-25787	CC	denotes	or
T5954	25788-25798	JJ	denotes	metatarsal
T5955	25799-25809	JJ	denotes	phalangeal
T5956	25798-25799	HYPH	denotes	-
T5957	25817-25819	IN	denotes	at
T5958	25820-25825	NN	denotes	E13.5
T5959	25826-25828	CC	denotes	or
T5960	25829-25834	NN	denotes	E14.5
T5961	25835-25836	-LRB-	denotes	(
T5962	25848-25852	NNS	denotes	data
T5963	25836-25847	JJ	denotes	unpublished
T5964	25852-25853	-RRB-	denotes	)
T5965	25853-25854	.	denotes	.
T5966	25854-26135	sentence	denotes	Similarly, although clear LACZ expression was seen by E15.5 in interphalangeal joints and periarticular regions (Figure 4D), no difference in morphology or expression of Col2a1, Gdf5, or Bmpr1b was seen in the articular regions of the phalanges at these stages (unpublished data).
T5967	25855-25864	RB	denotes	Similarly
T5968	26053-26057	VBN	denotes	seen
T5969	25864-25866	,	denotes	,
T5970	25866-25874	IN	denotes	although
T5971	25901-25905	VBN	denotes	seen
T5972	25875-25880	JJ	denotes	clear
T5973	25886-25896	NN	denotes	expression
T5974	25881-25885	NN	denotes	LACZ
T5975	25897-25900	VBD	denotes	was
T5976	25906-25908	IN	denotes	by
T5977	25909-25914	NN	denotes	E15.5
T5978	25915-25917	IN	denotes	in
T5979	25918-25933	JJ	denotes	interphalangeal
T5980	25934-25940	NNS	denotes	joints
T5981	25941-25944	CC	denotes	and
T5982	25945-25958	JJ	denotes	periarticular
T5983	25959-25966	NNS	denotes	regions
T5984	25967-25968	-LRB-	denotes	(
T5985	25968-25974	NN	denotes	Figure
T5986	25975-25977	CD	denotes	4D
T5987	25977-25978	-RRB-	denotes	)
T5988	25978-25980	,	denotes	,
T5989	25980-25982	DT	denotes	no
T5990	25983-25993	NN	denotes	difference
T5991	25994-25996	IN	denotes	in
T5992	25997-26007	NN	denotes	morphology
T5993	26008-26010	CC	denotes	or
T5994	26011-26021	NN	denotes	expression
T5995	26022-26024	IN	denotes	of
T5996	26025-26031	NN	denotes	Col2a1
T5997	26031-26033	,	denotes	,
T5998	26033-26037	NN	denotes	Gdf5
T5999	26037-26039	,	denotes	,
T6000	26039-26041	CC	denotes	or
T6001	26042-26048	NN	denotes	Bmpr1b
T6002	26049-26052	VBD	denotes	was
T6003	26058-26060	IN	denotes	in
T6004	26061-26064	DT	denotes	the
T6005	26075-26082	NNS	denotes	regions
T6006	26065-26074	JJ	denotes	articular
T6007	26083-26085	IN	denotes	of
T6008	26086-26089	DT	denotes	the
T6009	26090-26099	NNS	denotes	phalanges
T6010	26100-26102	IN	denotes	at
T6011	26103-26108	DT	denotes	these
T6012	26109-26115	NNS	denotes	stages
T6013	26116-26117	-LRB-	denotes	(
T6014	26129-26133	NNS	denotes	data
T6015	26117-26128	JJ	denotes	unpublished
T6016	26133-26134	-RRB-	denotes	)
T6017	26134-26135	.	denotes	.
T6018	26135-26405	sentence	denotes	At birth, digit joints were generally indistinguishable from those in control animals; chondrocytes were abundant in articular regions and were surrounded by typical cartilage matrix with normal staining by Safranin O, a histological stain for proteoglycans (Figure 5).
T6019	26136-26138	IN	denotes	At
T6020	26159-26163	VBD	denotes	were
T6021	26139-26144	NN	denotes	birth
T6022	26144-26146	,	denotes	,
T6023	26146-26151	NN	denotes	digit
T6024	26152-26158	NNS	denotes	joints
T6025	26236-26240	VBD	denotes	were
T6026	26164-26173	RB	denotes	generally
T6027	26174-26191	JJ	denotes	indistinguishable
T6028	26192-26196	IN	denotes	from
T6029	26197-26202	DT	denotes	those
T6030	26203-26205	IN	denotes	in
T6031	26206-26213	NN	denotes	control
T6032	26214-26221	NNS	denotes	animals
T6033	26221-26222	:	denotes	;
T6034	26223-26235	NNS	denotes	chondrocytes
T6035	26241-26249	JJ	denotes	abundant
T6036	26250-26252	IN	denotes	in
T6037	26253-26262	JJ	denotes	articular
T6038	26263-26270	NNS	denotes	regions
T6039	26271-26274	CC	denotes	and
T6040	26275-26279	VBD	denotes	were
T6041	26280-26290	VBN	denotes	surrounded
T6042	26291-26293	IN	denotes	by
T6043	26294-26301	JJ	denotes	typical
T6044	26312-26318	NN	denotes	matrix
T6045	26302-26311	NN	denotes	cartilage
T6046	26319-26323	IN	denotes	with
T6047	26324-26330	JJ	denotes	normal
T6048	26331-26339	NN	denotes	staining
T6049	26340-26342	IN	denotes	by
T6050	26343-26351	NN	denotes	Safranin
T6051	26352-26353	NN	denotes	O
T6052	26353-26355	,	denotes	,
T6053	26355-26356	DT	denotes	a
T6054	26370-26375	NN	denotes	stain
T6055	26357-26369	JJ	denotes	histological
T6056	26376-26379	IN	denotes	for
T6057	26380-26393	NNS	denotes	proteoglycans
T6058	26394-26395	-LRB-	denotes	(
T6059	26395-26401	NN	denotes	Figure
T6060	26402-26403	CD	denotes	5
T6061	26403-26404	-RRB-	denotes	)
T6062	26404-26405	.	denotes	.
T6063	26405-26638	sentence	denotes	At this stage, both wild-type and mutant cells in articular regions also expressed high levels of Col2a1 and Aggrecan (Agg), the genes encoding the major structural proteins of cartilage matrix (Figure 5B and 5G) (unpublished data).
T6064	26406-26408	IN	denotes	At
T6065	26479-26488	VBD	denotes	expressed
T6066	26409-26413	DT	denotes	this
T6067	26414-26419	NN	denotes	stage
T6068	26419-26421	,	denotes	,
T6069	26421-26425	CC	denotes	both
T6070	26431-26435	NN	denotes	type
T6071	26426-26430	JJ	denotes	wild
T6072	26430-26431	HYPH	denotes	-
T6073	26447-26452	NNS	denotes	cells
T6074	26436-26439	CC	denotes	and
T6075	26440-26446	JJ	denotes	mutant
T6076	26453-26455	IN	denotes	in
T6077	26456-26465	JJ	denotes	articular
T6078	26466-26473	NNS	denotes	regions
T6079	26474-26478	RB	denotes	also
T6080	26489-26493	JJ	denotes	high
T6081	26494-26500	NNS	denotes	levels
T6082	26501-26503	IN	denotes	of
T6083	26504-26510	NN	denotes	Col2a1
T6084	26511-26514	CC	denotes	and
T6085	26515-26523	NN	denotes	Aggrecan
T6086	26524-26525	-LRB-	denotes	(
T6087	26525-26528	NN	denotes	Agg
T6088	26528-26529	-RRB-	denotes	)
T6089	26529-26531	,	denotes	,
T6090	26531-26534	DT	denotes	the
T6091	26535-26540	NNS	denotes	genes
T6092	26541-26549	VBG	denotes	encoding
T6093	26550-26553	DT	denotes	the
T6094	26571-26579	NN	denotes	proteins
T6095	26554-26559	JJ	denotes	major
T6096	26560-26570	JJ	denotes	structural
T6097	26580-26582	IN	denotes	of
T6098	26583-26592	NN	denotes	cartilage
T6099	26593-26599	NN	denotes	matrix
T6100	26600-26601	-LRB-	denotes	(
T6101	26601-26607	NN	denotes	Figure
T6102	26608-26610	CD	denotes	5B
T6103	26611-26614	CC	denotes	and
T6104	26615-26617	CD	denotes	5G
T6105	26617-26618	-RRB-	denotes	)
T6106	26619-26620	-LRB-	denotes	(
T6107	26632-26636	NNS	denotes	data
T6108	26620-26631	JJ	denotes	unpublished
T6109	26636-26637	-RRB-	denotes	)
T6110	26637-26638	.	denotes	.
T6111	26638-26726	sentence	denotes	No alterations in cellular apoptosis or proliferation were observed (unpublished data).
T6112	26639-26641	DT	denotes	No
T6113	26642-26653	NNS	denotes	alterations
T6114	26698-26706	VBN	denotes	observed
T6115	26654-26656	IN	denotes	in
T6116	26657-26665	JJ	denotes	cellular
T6117	26666-26675	NN	denotes	apoptosis
T6118	26676-26678	CC	denotes	or
T6119	26679-26692	NN	denotes	proliferation
T6120	26693-26697	VBD	denotes	were
T6121	26707-26708	-LRB-	denotes	(
T6122	26720-26724	NNS	denotes	data
T6123	26708-26719	JJ	denotes	unpublished
T6124	26724-26725	-RRB-	denotes	)
T6125	26725-26726	.	denotes	.
T6126	26726-28235	sentence	denotes	Figure 5 Bmpr1a Is Required to Maintain Expression of ECM Components in Articular Cartilage In situ hybridization or LACZ staining on near adjacent sections of metacarpal-phalangeal joints (A–C and F–H) and the tarsal 2-metatarsal II joint (D–E and I–J) of P0 mice. At birth, articular cartilage of controls (A–E) and mutants (F–J) appears similar by Safranin O staining (A and F), and Col2 expression (B, G). Mat4 expression confirms that articular cartilage is initially specified in mutants (D andI, brackets). LACZ expression confirms Cre-mediated recombination has occurred in articular cartilage (C, H, E, and J). (K–T) Near adjacent sections of the metacarpal-phalangeal joints of P14 mice. Two weeks after birth, articular cartilage of controls stains with pericellular Safranin O (orange staining, K), and expresses Col2 (L), Agg (M), and SOX9 (N). In contrast, mutant articular cells are smaller and more densely packed, lack pericellular Safranin O staining (P), have reduced expression of Col2 (Q) and Agg (R), but retain normal levels of SOX9 protein (S, brackets; dashed line marks faint edges of articular surfaces). LACZ expression confirms Cre-mediated recombination has occurred in articular cells (O ansd T, brackets). (A and K) Scale bar = 75 μm. To determine whether articular cells were properly specified in mutants, we also analyzed expression of Matrilin-4 (Mat4), a gene expressed specifically in the periarticular and perichondral regions of developing joints (Klatt et al. 2001).
T6127	27995-27997	TO	denotes	To
T6128	27998-28007	VB	denotes	determine
T6129	28076-28084	VBD	denotes	analyzed
T6130	28008-28015	IN	denotes	whether
T6131	28046-28055	VBN	denotes	specified
T6132	28016-28025	JJ	denotes	articular
T6133	28026-28031	NNS	denotes	cells
T6134	28032-28036	VBD	denotes	were
T6135	28037-28045	RB	denotes	properly
T6136	28056-28058	IN	denotes	in
T6137	28059-28066	NNS	denotes	mutants
T6138	28066-28068	,	denotes	,
T6139	28068-28070	PRP	denotes	we
T6140	28071-28075	RB	denotes	also
T6141	28085-28095	NN	denotes	expression
T6142	28096-28098	IN	denotes	of
T6143	28099-28107	NN	denotes	Matrilin
T6144	28107-28108	HYPH	denotes	-
T6145	28108-28109	CD	denotes	4
T6146	28110-28111	-LRB-	denotes	(
T6147	28111-28115	NN	denotes	Mat4
T6148	28115-28116	-RRB-	denotes	)
T6149	28116-28118	,	denotes	,
T6150	28118-28119	DT	denotes	a
T6151	28120-28124	NN	denotes	gene
T6152	28125-28134	VBN	denotes	expressed
T6153	28135-28147	RB	denotes	specifically
T6154	28148-28150	IN	denotes	in
T6155	28151-28154	DT	denotes	the
T6156	28186-28193	NNS	denotes	regions
T6157	28155-28168	JJ	denotes	periarticular
T6158	28169-28172	CC	denotes	and
T6159	28173-28185	JJ	denotes	perichondral
T6160	28194-28196	IN	denotes	of
T6161	28197-28207	VBG	denotes	developing
T6162	28208-28214	NNS	denotes	joints
T6163	28215-28216	-LRB-	denotes	(
T6164	28216-28221	NNP	denotes	Klatt
T6165	28222-28224	FW	denotes	et
T6166	28225-28228	FW	denotes	al.
T6167	28229-28233	CD	denotes	2001
T6168	28233-28234	-RRB-	denotes	)
T6169	28234-28235	.	denotes	.
T6170	28235-28388	sentence	denotes	In both control and mutant animals, transcription of Mat4 was clearly detectable in the articular cartilage layers of newborn joints (Figure 5D and 5I).
T6171	28236-28238	IN	denotes	In
T6172	28294-28297	VBD	denotes	was
T6173	28239-28243	CC	denotes	both
T6174	28244-28251	NN	denotes	control
T6175	28263-28270	NNS	denotes	animals
T6176	28252-28255	CC	denotes	and
T6177	28256-28262	JJ	denotes	mutant
T6178	28270-28272	,	denotes	,
T6179	28272-28285	NN	denotes	transcription
T6180	28286-28288	IN	denotes	of
T6181	28289-28293	NN	denotes	Mat4
T6182	28298-28305	RB	denotes	clearly
T6183	28306-28316	JJ	denotes	detectable
T6184	28317-28319	IN	denotes	in
T6185	28320-28323	DT	denotes	the
T6186	28344-28350	NNS	denotes	layers
T6187	28324-28333	JJ	denotes	articular
T6188	28334-28343	NN	denotes	cartilage
T6189	28351-28353	IN	denotes	of
T6190	28354-28361	JJ	denotes	newborn
T6191	28362-28368	NNS	denotes	joints
T6192	28369-28370	-LRB-	denotes	(
T6193	28377-28379	CD	denotes	5D
T6194	28370-28376	NN	denotes	Figure
T6195	28380-28383	CC	denotes	and
T6196	28384-28386	CD	denotes	5I
T6197	28386-28387	-RRB-	denotes	)
T6198	28387-28388	.	denotes	.
T6199	28388-28573	sentence	denotes	In all experiments, expression of LACZ throughout articular regions indicated that Cre-mediated recombination had occurred throughout the articular regions (Figure 5C, 5H, 5E, and 5J).
T6200	28389-28391	IN	denotes	In
T6201	28457-28466	VBD	denotes	indicated
T6202	28392-28395	DT	denotes	all
T6203	28396-28407	NNS	denotes	experiments
T6204	28407-28409	,	denotes	,
T6205	28409-28419	NN	denotes	expression
T6206	28420-28422	IN	denotes	of
T6207	28423-28427	NN	denotes	LACZ
T6208	28428-28438	IN	denotes	throughout
T6209	28439-28448	JJ	denotes	articular
T6210	28449-28456	NNS	denotes	regions
T6211	28467-28471	IN	denotes	that
T6212	28503-28511	VBN	denotes	occurred
T6213	28472-28475	NN	denotes	Cre
T6214	28476-28484	VBN	denotes	mediated
T6215	28475-28476	HYPH	denotes	-
T6216	28485-28498	NN	denotes	recombination
T6217	28499-28502	VBD	denotes	had
T6218	28512-28522	IN	denotes	throughout
T6219	28523-28526	DT	denotes	the
T6220	28537-28544	NNS	denotes	regions
T6221	28527-28536	JJ	denotes	articular
T6222	28545-28546	-LRB-	denotes	(
T6223	28546-28552	NN	denotes	Figure
T6224	28553-28555	CD	denotes	5C
T6225	28555-28557	,	denotes	,
T6226	28557-28559	CD	denotes	5H
T6227	28559-28561	,	denotes	,
T6228	28561-28563	CD	denotes	5E
T6229	28563-28565	,	denotes	,
T6230	28565-28568	CC	denotes	and
T6231	28569-28571	CD	denotes	5J
T6232	28571-28572	-RRB-	denotes	)
T6233	28572-28573	.	denotes	.
T6234	28573-28769	sentence	denotes	The normal histological appearance, staining properties, and marker gene expression patterns suggest that Bmpr1a is not required for the initial formation or specification of articular cartilage.
T6235	28574-28577	DT	denotes	The
T6236	28598-28608	NN	denotes	appearance
T6237	28578-28584	JJ	denotes	normal
T6238	28585-28597	JJ	denotes	histological
T6239	28667-28674	VBP	denotes	suggest
T6240	28608-28610	,	denotes	,
T6241	28610-28618	VBG	denotes	staining
T6242	28619-28629	NNS	denotes	properties
T6243	28629-28631	,	denotes	,
T6244	28631-28634	CC	denotes	and
T6245	28635-28641	NN	denotes	marker
T6246	28642-28646	NN	denotes	gene
T6247	28658-28666	NNS	denotes	patterns
T6248	28647-28657	NN	denotes	expression
T6249	28675-28679	IN	denotes	that
T6250	28694-28702	VBN	denotes	required
T6251	28680-28686	NN	denotes	Bmpr1a
T6252	28687-28689	VBZ	denotes	is
T6253	28690-28693	RB	denotes	not
T6254	28703-28706	IN	denotes	for
T6255	28707-28710	DT	denotes	the
T6256	28719-28728	NN	denotes	formation
T6257	28711-28718	JJ	denotes	initial
T6258	28729-28731	CC	denotes	or
T6259	28732-28745	NN	denotes	specification
T6260	28746-28748	IN	denotes	of
T6261	28749-28758	JJ	denotes	articular
T6262	28759-28768	NN	denotes	cartilage
T6263	28768-28769	.	denotes	.
T6264	28769-28875	sentence	denotes	By 1 wk after birth, obvious differences began to be detected in the articular regions of mutant animals.
T6265	28770-28772	IN	denotes	By
T6266	28811-28816	VBD	denotes	began
T6267	28773-28774	CD	denotes	1
T6268	28775-28777	NN	denotes	wk
T6269	28778-28783	IN	denotes	after
T6270	28784-28789	NN	denotes	birth
T6271	28789-28791	,	denotes	,
T6272	28791-28798	JJ	denotes	obvious
T6273	28799-28810	NNS	denotes	differences
T6274	28817-28819	TO	denotes	to
T6275	28823-28831	VBN	denotes	detected
T6276	28820-28822	VB	denotes	be
T6277	28832-28834	IN	denotes	in
T6278	28835-28838	DT	denotes	the
T6279	28849-28856	NNS	denotes	regions
T6280	28839-28848	JJ	denotes	articular
T6281	28857-28859	IN	denotes	of
T6282	28860-28866	NN	denotes	mutant
T6283	28867-28874	NNS	denotes	animals
T6284	28874-28875	.	denotes	.
T6285	28875-29025	sentence	denotes	The expression of Col2a1 was reduced throughout the articular surfaces of the carpals, metacarpals, and phalanges of the forefeet (unpublished data).
T6286	28876-28879	DT	denotes	The
T6287	28880-28890	NN	denotes	expression
T6288	28905-28912	VBN	denotes	reduced
T6289	28891-28893	IN	denotes	of
T6290	28894-28900	NN	denotes	Col2a1
T6291	28901-28904	VBD	denotes	was
T6292	28913-28923	IN	denotes	throughout
T6293	28924-28927	DT	denotes	the
T6294	28938-28946	NNS	denotes	surfaces
T6295	28928-28937	JJ	denotes	articular
T6296	28947-28949	IN	denotes	of
T6297	28950-28953	DT	denotes	the
T6298	28954-28961	NNS	denotes	carpals
T6299	28961-28963	,	denotes	,
T6300	28963-28974	NNS	denotes	metacarpals
T6301	28974-28976	,	denotes	,
T6302	28976-28979	CC	denotes	and
T6303	28980-28989	NNS	denotes	phalanges
T6304	28990-28992	IN	denotes	of
T6305	28993-28996	DT	denotes	the
T6306	28997-29005	NNS	denotes	forefeet
T6307	29006-29007	-LRB-	denotes	(
T6308	29019-29023	NNS	denotes	data
T6309	29007-29018	JJ	denotes	unpublished
T6310	29023-29024	-RRB-	denotes	)
T6311	29024-29025	.	denotes	.
T6312	29025-29145	sentence	denotes	Less severe reductions were also seen in articular cells of tarsals and metatarsals in the hindfeet (unpublished data).
T6313	29026-29030	RBR	denotes	Less
T6314	29031-29037	JJ	denotes	severe
T6315	29038-29048	NNS	denotes	reductions
T6316	29059-29063	VBN	denotes	seen
T6317	29049-29053	VBD	denotes	were
T6318	29054-29058	RB	denotes	also
T6319	29064-29066	IN	denotes	in
T6320	29067-29076	JJ	denotes	articular
T6321	29077-29082	NNS	denotes	cells
T6322	29083-29085	IN	denotes	of
T6323	29086-29093	NNS	denotes	tarsals
T6324	29094-29097	CC	denotes	and
T6325	29098-29109	NNS	denotes	metatarsals
T6326	29110-29112	IN	denotes	in
T6327	29113-29116	DT	denotes	the
T6328	29117-29125	NN	denotes	hindfeet
T6329	29126-29127	-LRB-	denotes	(
T6330	29139-29143	NNS	denotes	data
T6331	29127-29138	JJ	denotes	unpublished
T6332	29143-29144	-RRB-	denotes	)
T6333	29144-29145	.	denotes	.
T6334	29145-29525	sentence	denotes	By 2 wk of age, Col2a1 expression was reduced in most cells of the articular region (Figure 5L and 5Q), accompanied by markedly reduced Safranin O staining (Figure 5K and 5P), and decreased expression of Agg and two genes normally expressed in more mature articular cartilage cells, Collagen 3 (Col3a1) and Collagen 10 (Col10a1) (Figure 5M and 5R) (unpublished data) (Eyre 2002).
T6335	29146-29148	IN	denotes	By
T6336	29184-29191	VBN	denotes	reduced
T6337	29149-29150	CD	denotes	2
T6338	29151-29153	NNS	denotes	wk
T6339	29154-29156	IN	denotes	of
T6340	29157-29160	NN	denotes	age
T6341	29160-29162	,	denotes	,
T6342	29162-29168	NN	denotes	Col2a1
T6343	29169-29179	NN	denotes	expression
T6344	29180-29183	VBD	denotes	was
T6345	29192-29194	IN	denotes	in
T6346	29195-29199	JJS	denotes	most
T6347	29200-29205	NNS	denotes	cells
T6348	29206-29208	IN	denotes	of
T6349	29209-29212	DT	denotes	the
T6350	29223-29229	NN	denotes	region
T6351	29213-29222	JJ	denotes	articular
T6352	29230-29231	-LRB-	denotes	(
T6353	29231-29237	NN	denotes	Figure
T6354	29238-29240	CD	denotes	5L
T6355	29241-29244	CC	denotes	and
T6356	29245-29247	CD	denotes	5Q
T6357	29247-29248	-RRB-	denotes	)
T6358	29248-29250	,	denotes	,
T6359	29250-29261	VBN	denotes	accompanied
T6360	29262-29264	IN	denotes	by
T6361	29265-29273	RB	denotes	markedly
T6362	29274-29281	VBN	denotes	reduced
T6363	29293-29301	NN	denotes	staining
T6364	29282-29290	NN	denotes	Safranin
T6365	29291-29292	NN	denotes	O
T6366	29302-29303	-LRB-	denotes	(
T6367	29303-29309	NN	denotes	Figure
T6368	29310-29312	CD	denotes	5K
T6369	29313-29316	CC	denotes	and
T6370	29317-29319	CD	denotes	5P
T6371	29319-29320	-RRB-	denotes	)
T6372	29320-29322	,	denotes	,
T6373	29322-29325	CC	denotes	and
T6374	29326-29335	VBN	denotes	decreased
T6375	29336-29346	NN	denotes	expression
T6376	29347-29349	IN	denotes	of
T6377	29350-29353	NN	denotes	Agg
T6378	29354-29357	CC	denotes	and
T6379	29358-29361	CD	denotes	two
T6380	29362-29367	NNS	denotes	genes
T6381	29368-29376	RB	denotes	normally
T6382	29377-29386	VBN	denotes	expressed
T6383	29387-29389	IN	denotes	in
T6384	29390-29394	RBR	denotes	more
T6385	29395-29401	JJ	denotes	mature
T6386	29422-29427	NNS	denotes	cells
T6387	29402-29411	JJ	denotes	articular
T6388	29412-29421	NN	denotes	cartilage
T6389	29427-29429	,	denotes	,
T6390	29429-29437	NN	denotes	Collagen
T6391	29438-29439	CD	denotes	3
T6392	29440-29441	-LRB-	denotes	(
T6393	29441-29447	NN	denotes	Col3a1
T6394	29447-29448	-RRB-	denotes	)
T6395	29449-29452	CC	denotes	and
T6396	29453-29461	NN	denotes	Collagen
T6397	29462-29464	CD	denotes	10
T6398	29465-29466	-LRB-	denotes	(
T6399	29466-29473	NN	denotes	Col10a1
T6400	29473-29474	-RRB-	denotes	)
T6401	29475-29476	-LRB-	denotes	(
T6402	29476-29482	NN	denotes	Figure
T6403	29483-29485	CD	denotes	5M
T6404	29486-29489	CC	denotes	and
T6405	29490-29492	CD	denotes	5R
T6406	29492-29493	-RRB-	denotes	)
T6407	29494-29495	-LRB-	denotes	(
T6408	29507-29511	NNS	denotes	data
T6409	29495-29506	JJ	denotes	unpublished
T6410	29511-29512	-RRB-	denotes	)
T6411	29513-29514	-LRB-	denotes	(
T6412	29514-29518	NN	denotes	Eyre
T6413	29519-29523	CD	denotes	2002
T6414	29523-29524	-RRB-	denotes	)
T6415	29524-29525	.	denotes	.
T6416	29525-29767	sentence	denotes	Inhibition of BMP signaling in cultured chondrocytes has previously been reported to induce Collagen 1 (Col1a1) expression, increase proliferation, and result in cells with flattened, fibroblast-like morphology (Enomoto-Iwamoto et al. 1998).
T6417	29526-29536	NN	denotes	Inhibition
T6418	29599-29607	VBN	denotes	reported
T6419	29537-29539	IN	denotes	of
T6420	29540-29543	NN	denotes	BMP
T6421	29544-29553	NN	denotes	signaling
T6422	29554-29556	IN	denotes	in
T6423	29557-29565	VBN	denotes	cultured
T6424	29566-29578	NNS	denotes	chondrocytes
T6425	29579-29582	VBZ	denotes	has
T6426	29583-29593	RB	denotes	previously
T6427	29594-29598	VBN	denotes	been
T6428	29608-29610	TO	denotes	to
T6429	29611-29617	VB	denotes	induce
T6430	29618-29626	NN	denotes	Collagen
T6431	29638-29648	NN	denotes	expression
T6432	29627-29628	CD	denotes	1
T6433	29629-29630	-LRB-	denotes	(
T6434	29630-29636	NN	denotes	Col1a1
T6435	29636-29637	-RRB-	denotes	)
T6436	29648-29650	,	denotes	,
T6437	29650-29658	VB	denotes	increase
T6438	29659-29672	NN	denotes	proliferation
T6439	29672-29674	,	denotes	,
T6440	29674-29677	CC	denotes	and
T6441	29678-29684	VB	denotes	result
T6442	29685-29687	IN	denotes	in
T6443	29688-29693	NNS	denotes	cells
T6444	29694-29698	IN	denotes	with
T6445	29699-29708	VBN	denotes	flattened
T6446	29726-29736	NN	denotes	morphology
T6447	29708-29710	,	denotes	,
T6448	29710-29720	NN	denotes	fibroblast
T6449	29721-29725	JJ	denotes	like
T6450	29720-29721	HYPH	denotes	-
T6451	29737-29738	-LRB-	denotes	(
T6452	29738-29745	NNP	denotes	Enomoto
T6453	29745-29746	HYPH	denotes	-
T6454	29746-29753	NNP	denotes	Iwamoto
T6455	29754-29756	FW	denotes	et
T6456	29757-29760	FW	denotes	al.
T6457	29761-29765	CD	denotes	1998
T6458	29765-29766	-RRB-	denotes	)
T6459	29766-29767	.	denotes	.
T6460	29767-29963	sentence	denotes	However, we saw no increase in the expression of Col1a1 in mutant articular cartilage, and no proliferation was detected in articular cells of either mutant or control animals (unpublished data).
T6461	29768-29775	RB	denotes	However
T6462	29780-29783	VBD	denotes	saw
T6463	29775-29777	,	denotes	,
T6464	29777-29779	PRP	denotes	we
T6465	29784-29786	DT	denotes	no
T6466	29787-29795	NN	denotes	increase
T6467	29796-29798	IN	denotes	in
T6468	29799-29802	DT	denotes	the
T6469	29803-29813	NN	denotes	expression
T6470	29814-29816	IN	denotes	of
T6471	29817-29823	NN	denotes	Col1a1
T6472	29824-29826	IN	denotes	in
T6473	29827-29833	NN	denotes	mutant
T6474	29844-29853	NN	denotes	cartilage
T6475	29834-29843	JJ	denotes	articular
T6476	29853-29855	,	denotes	,
T6477	29855-29858	CC	denotes	and
T6478	29859-29861	DT	denotes	no
T6479	29862-29875	NN	denotes	proliferation
T6480	29880-29888	VBN	denotes	detected
T6481	29876-29879	VBD	denotes	was
T6482	29889-29891	IN	denotes	in
T6483	29892-29901	JJ	denotes	articular
T6484	29902-29907	NNS	denotes	cells
T6485	29908-29910	IN	denotes	of
T6486	29911-29917	CC	denotes	either
T6487	29918-29924	JJ	denotes	mutant
T6488	29936-29943	NNS	denotes	animals
T6489	29925-29927	CC	denotes	or
T6490	29928-29935	NN	denotes	control
T6491	29944-29945	-LRB-	denotes	(
T6492	29957-29961	NNS	denotes	data
T6493	29945-29956	JJ	denotes	unpublished
T6494	29961-29962	-RRB-	denotes	)
T6495	29962-29963	.	denotes	.
T6496	29963-30194	sentence	denotes	While recombined LACZ marker expression was detected in most articular cartilage cells, it was also observed in scattered subarticular chondrocytes, growth plate chondrocytes, and osteoblasts (Figure 5O and 5T) (unpublished data).
T6497	29964-29969	IN	denotes	While
T6498	30008-30016	VBN	denotes	detected
T6499	29970-29980	VBN	denotes	recombined
T6500	29993-30003	NN	denotes	expression
T6501	29981-29985	NN	denotes	LACZ
T6502	29986-29992	NN	denotes	marker
T6503	30004-30007	VBD	denotes	was
T6504	30064-30072	VBN	denotes	observed
T6505	30017-30019	IN	denotes	in
T6506	30020-30024	JJS	denotes	most
T6507	30045-30050	NNS	denotes	cells
T6508	30025-30034	JJ	denotes	articular
T6509	30035-30044	NN	denotes	cartilage
T6510	30050-30052	,	denotes	,
T6511	30052-30054	PRP	denotes	it
T6512	30055-30058	VBD	denotes	was
T6513	30059-30063	RB	denotes	also
T6514	30073-30075	IN	denotes	in
T6515	30076-30085	VBN	denotes	scattered
T6516	30099-30111	NNS	denotes	chondrocytes
T6517	30086-30098	JJ	denotes	subarticular
T6518	30111-30113	,	denotes	,
T6519	30113-30119	NN	denotes	growth
T6520	30120-30125	NN	denotes	plate
T6521	30126-30138	NNS	denotes	chondrocytes
T6522	30138-30140	,	denotes	,
T6523	30140-30143	CC	denotes	and
T6524	30144-30155	NNS	denotes	osteoblasts
T6525	30156-30157	-LRB-	denotes	(
T6526	30157-30163	NN	denotes	Figure
T6527	30164-30166	CD	denotes	5O
T6528	30167-30170	CC	denotes	and
T6529	30171-30173	CD	denotes	5T
T6530	30173-30174	-RRB-	denotes	)
T6531	30175-30176	-LRB-	denotes	(
T6532	30188-30192	NNS	denotes	data
T6533	30176-30187	JJ	denotes	unpublished
T6534	30192-30193	-RRB-	denotes	)
T6535	30193-30194	.	denotes	.
T6536	30194-30336	sentence	denotes	Although this implies that BMP signaling was defective in multiple cell types, the observed defects were confined to the articular cartilage.
T6537	30195-30203	IN	denotes	Although
T6538	30209-30216	VBZ	denotes	implies
T6539	30204-30208	DT	denotes	this
T6540	30300-30308	VBN	denotes	confined
T6541	30217-30221	IN	denotes	that
T6542	30236-30239	VBD	denotes	was
T6543	30222-30225	NN	denotes	BMP
T6544	30226-30235	NN	denotes	signaling
T6545	30240-30249	JJ	denotes	defective
T6546	30250-30252	IN	denotes	in
T6547	30253-30261	JJ	denotes	multiple
T6548	30267-30272	NNS	denotes	types
T6549	30262-30266	NN	denotes	cell
T6550	30272-30274	,	denotes	,
T6551	30274-30277	DT	denotes	the
T6552	30287-30294	NNS	denotes	defects
T6553	30278-30286	VBN	denotes	observed
T6554	30295-30299	VBD	denotes	were
T6555	30309-30311	IN	denotes	to
T6556	30312-30315	DT	denotes	the
T6557	30326-30335	NN	denotes	cartilage
T6558	30316-30325	JJ	denotes	articular
T6559	30335-30336	.	denotes	.
T6560	30336-30434	sentence	denotes	For example, Osteocalcin and Col1a1 expression appeared normal in osteoblasts (unpublished data).
T6561	30337-30340	IN	denotes	For
T6562	30384-30392	VBD	denotes	appeared
T6563	30341-30348	NN	denotes	example
T6564	30348-30350	,	denotes	,
T6565	30350-30361	NN	denotes	Osteocalcin
T6566	30373-30383	NN	denotes	expression
T6567	30362-30365	CC	denotes	and
T6568	30366-30372	NN	denotes	Col1a1
T6569	30393-30399	JJ	denotes	normal
T6570	30400-30402	IN	denotes	in
T6571	30403-30414	NNS	denotes	osteoblasts
T6572	30415-30416	-LRB-	denotes	(
T6573	30428-30432	NNS	denotes	data
T6574	30416-30427	JJ	denotes	unpublished
T6575	30432-30433	-RRB-	denotes	)
T6576	30433-30434	.	denotes	.
T6577	30434-30624	sentence	denotes	Together, these data suggest that BMPR1A activity is required in postnatal joint articular cartilage to maintain expression of many genes encoding structural components of cartilage matrix.
T6578	30435-30443	RB	denotes	Together
T6579	30456-30463	VBP	denotes	suggest
T6580	30443-30445	,	denotes	,
T6581	30445-30450	DT	denotes	these
T6582	30451-30455	NNS	denotes	data
T6583	30464-30468	IN	denotes	that
T6584	30488-30496	VBN	denotes	required
T6585	30469-30475	NN	denotes	BMPR1A
T6586	30476-30484	NN	denotes	activity
T6587	30485-30487	VBZ	denotes	is
T6588	30497-30499	IN	denotes	in
T6589	30500-30509	JJ	denotes	postnatal
T6590	30526-30535	NN	denotes	cartilage
T6591	30510-30515	NN	denotes	joint
T6592	30516-30525	JJ	denotes	articular
T6593	30536-30538	TO	denotes	to
T6594	30539-30547	VB	denotes	maintain
T6595	30548-30558	NN	denotes	expression
T6596	30559-30561	IN	denotes	of
T6597	30562-30566	JJ	denotes	many
T6598	30567-30572	NNS	denotes	genes
T6599	30573-30581	VBG	denotes	encoding
T6600	30582-30592	JJ	denotes	structural
T6601	30593-30603	NNS	denotes	components
T6602	30604-30606	IN	denotes	of
T6603	30607-30616	NN	denotes	cartilage
T6604	30617-30623	NN	denotes	matrix
T6605	30623-30624	.	denotes	.
T6606	30624-30948	sentence	denotes	Previous studies have shown that Sox9 is required for normal cartilage differentiation, for expression of cartilage extracellular matrix (ECM) genes including Agg, and is a direct transcriptional regulator of the key cartilage matrix gene Col2a1 (Bell et al. 1997; Lefebvre et al. 1997; Bi et al. 1999; Sekiya et al. 2000).
T6607	30625-30633	JJ	denotes	Previous
T6608	30634-30641	NNS	denotes	studies
T6609	30647-30652	VBN	denotes	shown
T6610	30642-30646	VBP	denotes	have
T6611	30653-30657	IN	denotes	that
T6612	30666-30674	VBN	denotes	required
T6613	30658-30662	NN	denotes	Sox9
T6614	30663-30665	VBZ	denotes	is
T6615	30675-30678	IN	denotes	for
T6616	30679-30685	JJ	denotes	normal
T6617	30696-30711	NN	denotes	differentiation
T6618	30686-30695	NN	denotes	cartilage
T6619	30711-30713	,	denotes	,
T6620	30713-30716	IN	denotes	for
T6621	30717-30727	NN	denotes	expression
T6622	30728-30730	IN	denotes	of
T6623	30731-30740	NN	denotes	cartilage
T6624	30755-30761	NN	denotes	matrix
T6625	30741-30754	JJ	denotes	extracellular
T6626	30768-30773	NNS	denotes	genes
T6627	30762-30763	-LRB-	denotes	(
T6628	30763-30766	NN	denotes	ECM
T6629	30766-30767	-RRB-	denotes	)
T6630	30774-30783	VBG	denotes	including
T6631	30784-30787	NN	denotes	Agg
T6632	30787-30789	,	denotes	,
T6633	30789-30792	CC	denotes	and
T6634	30793-30795	VBZ	denotes	is
T6635	30796-30797	DT	denotes	a
T6636	30821-30830	NN	denotes	regulator
T6637	30798-30804	JJ	denotes	direct
T6638	30805-30820	JJ	denotes	transcriptional
T6639	30831-30833	IN	denotes	of
T6640	30834-30837	DT	denotes	the
T6641	30864-30870	NN	denotes	Col2a1
T6642	30838-30841	JJ	denotes	key
T6643	30842-30851	NN	denotes	cartilage
T6644	30852-30858	NN	denotes	matrix
T6645	30859-30863	NN	denotes	gene
T6646	30871-30872	-LRB-	denotes	(
T6647	30872-30876	NNP	denotes	Bell
T6648	30877-30879	FW	denotes	et
T6649	30880-30883	FW	denotes	al.
T6650	30884-30888	CD	denotes	1997
T6651	30888-30889	:	denotes	;
T6652	30890-30898	NNP	denotes	Lefebvre
T6653	30899-30901	FW	denotes	et
T6654	30902-30905	FW	denotes	al.
T6655	30906-30910	CD	denotes	1997
T6656	30910-30911	:	denotes	;
T6657	30912-30914	NNP	denotes	Bi
T6658	30915-30917	FW	denotes	et
T6659	30918-30921	FW	denotes	al.
T6660	30922-30926	CD	denotes	1999
T6661	30926-30927	:	denotes	;
T6662	30928-30934	NNP	denotes	Sekiya
T6663	30935-30937	FW	denotes	et
T6664	30938-30941	FW	denotes	al.
T6665	30942-30946	CD	denotes	2000
T6666	30946-30947	-RRB-	denotes	)
T6667	30947-30948	.	denotes	.
T6668	30948-31232	sentence	denotes	Notably, despite reduced expression of many cartilage matrix marker genes in Bmpr1a mutant mice, the SOX9 protein was present at normal levels in articular regions at all stages examined, including newborn, 2-wk-old, 7-wk-old, and 9-mo-old mice (Figure 5N and 5S) (unpublished data).
T6669	30949-30956	RB	denotes	Notably
T6670	31063-31066	VBD	denotes	was
T6671	30956-30958	,	denotes	,
T6672	30958-30965	IN	denotes	despite
T6673	30966-30973	VBN	denotes	reduced
T6674	30974-30984	NN	denotes	expression
T6675	30985-30987	IN	denotes	of
T6676	30988-30992	JJ	denotes	many
T6677	31017-31022	NNS	denotes	genes
T6678	30993-31002	NN	denotes	cartilage
T6679	31003-31009	NN	denotes	matrix
T6680	31010-31016	NN	denotes	marker
T6681	31023-31025	IN	denotes	in
T6682	31026-31032	NN	denotes	Bmpr1a
T6683	31033-31039	JJ	denotes	mutant
T6684	31040-31044	NNS	denotes	mice
T6685	31044-31046	,	denotes	,
T6686	31046-31049	DT	denotes	the
T6687	31055-31062	NN	denotes	protein
T6688	31050-31054	NN	denotes	SOX9
T6689	31067-31074	JJ	denotes	present
T6690	31075-31077	IN	denotes	at
T6691	31078-31084	JJ	denotes	normal
T6692	31085-31091	NNS	denotes	levels
T6693	31092-31094	IN	denotes	in
T6694	31095-31104	JJ	denotes	articular
T6695	31105-31112	NNS	denotes	regions
T6696	31113-31115	IN	denotes	at
T6697	31116-31119	DT	denotes	all
T6698	31120-31126	NNS	denotes	stages
T6699	31127-31135	VBN	denotes	examined
T6700	31135-31137	,	denotes	,
T6701	31137-31146	VBG	denotes	including
T6702	31147-31154	JJ	denotes	newborn
T6703	31189-31193	NNS	denotes	mice
T6704	31154-31156	,	denotes	,
T6705	31156-31157	CD	denotes	2
T6706	31158-31160	NN	denotes	wk
T6707	31157-31158	HYPH	denotes	-
T6708	31161-31164	JJ	denotes	old
T6709	31160-31161	HYPH	denotes	-
T6710	31164-31166	,	denotes	,
T6711	31166-31167	CD	denotes	7
T6712	31168-31170	NN	denotes	wk
T6713	31167-31168	HYPH	denotes	-
T6714	31171-31174	JJ	denotes	old
T6715	31170-31171	HYPH	denotes	-
T6716	31174-31176	,	denotes	,
T6717	31176-31179	CC	denotes	and
T6718	31180-31181	CD	denotes	9
T6719	31182-31184	NN	denotes	mo
T6720	31181-31182	HYPH	denotes	-
T6721	31185-31188	JJ	denotes	old
T6722	31184-31185	HYPH	denotes	-
T6723	31194-31195	-LRB-	denotes	(
T6724	31195-31201	NN	denotes	Figure
T6725	31202-31204	CD	denotes	5N
T6726	31205-31208	CC	denotes	and
T6727	31209-31211	CD	denotes	5S
T6728	31211-31212	-RRB-	denotes	)
T6729	31213-31214	-LRB-	denotes	(
T6730	31226-31230	NNS	denotes	data
T6731	31214-31225	JJ	denotes	unpublished
T6732	31230-31231	-RRB-	denotes	)
T6733	31231-31232	.	denotes	.
T6897	31234-31242	JJ	denotes	Synovial
T6898	31243-31254	NN	denotes	Hypertrophy
T6899	31254-31256	,	denotes	,
T6900	31256-31265	NN	denotes	Cartilage
T6901	31266-31273	NN	denotes	Erosion
T6902	31273-31275	,	denotes	,
T6903	31275-31278	CC	denotes	and
T6904	31279-31290	VBN	denotes	Accelerated
T6905	31301-31311	NN	denotes	Maturation
T6906	31291-31300	NN	denotes	Cartilage
T6907	31311-31460	sentence	denotes	Conditional loss of Bmpr1a led to marked hypertrophy of the synovial membrane in the joint capsule of some joints, particularly in the ankle region.
T6908	31312-31323	JJ	denotes	Conditional
T6909	31324-31328	NN	denotes	loss
T6910	31339-31342	VBD	denotes	led
T6911	31329-31331	IN	denotes	of
T6912	31332-31338	NN	denotes	Bmpr1a
T6913	31343-31345	IN	denotes	to
T6914	31346-31352	VBN	denotes	marked
T6915	31353-31364	NN	denotes	hypertrophy
T6916	31365-31367	IN	denotes	of
T6917	31368-31371	DT	denotes	the
T6918	31381-31389	NN	denotes	membrane
T6919	31372-31380	JJ	denotes	synovial
T6920	31390-31392	IN	denotes	in
T6921	31393-31396	DT	denotes	the
T6922	31403-31410	NN	denotes	capsule
T6923	31397-31402	NN	denotes	joint
T6924	31411-31413	IN	denotes	of
T6925	31414-31418	DT	denotes	some
T6926	31419-31425	NNS	denotes	joints
T6927	31425-31427	,	denotes	,
T6928	31427-31439	RB	denotes	particularly
T6929	31440-31442	IN	denotes	in
T6930	31443-31446	DT	denotes	the
T6931	31453-31459	NN	denotes	region
T6932	31447-31452	NN	denotes	ankle
T6933	31459-31460	.	denotes	.
T6934	31460-31669	sentence	denotes	In the most severely affected joints, the expanded synovial membrane grew into the joint space and was associated with obvious loss or erosion of the articular cartilage (Figure 6A and 6B, asterisks, arrows).
T6935	31461-31463	IN	denotes	In
T6936	31530-31534	VBD	denotes	grew
T6937	31464-31467	DT	denotes	the
T6938	31491-31497	NNS	denotes	joints
T6939	31468-31472	RBS	denotes	most
T6940	31473-31481	RB	denotes	severely
T6941	31482-31490	VBN	denotes	affected
T6942	31497-31499	,	denotes	,
T6943	31499-31502	DT	denotes	the
T6944	31521-31529	NN	denotes	membrane
T6945	31503-31511	VBN	denotes	expanded
T6946	31512-31520	JJ	denotes	synovial
T6947	31535-31539	IN	denotes	into
T6948	31540-31543	DT	denotes	the
T6949	31550-31555	NN	denotes	space
T6950	31544-31549	NN	denotes	joint
T6951	31556-31559	CC	denotes	and
T6952	31560-31563	VBD	denotes	was
T6953	31564-31574	VBN	denotes	associated
T6954	31575-31579	IN	denotes	with
T6955	31580-31587	JJ	denotes	obvious
T6956	31588-31592	NN	denotes	loss
T6957	31593-31595	CC	denotes	or
T6958	31596-31603	NN	denotes	erosion
T6959	31604-31606	IN	denotes	of
T6960	31607-31610	DT	denotes	the
T6961	31621-31630	NN	denotes	cartilage
T6962	31611-31620	JJ	denotes	articular
T6963	31631-31632	-LRB-	denotes	(
T6964	31661-31667	NNS	denotes	arrows
T6965	31632-31638	NN	denotes	Figure
T6966	31639-31641	CD	denotes	6A
T6967	31642-31645	CC	denotes	and
T6968	31646-31648	CD	denotes	6B
T6969	31648-31650	,	denotes	,
T6970	31650-31659	NNS	denotes	asterisks
T6971	31659-31661	,	denotes	,
T6972	31667-31668	-RRB-	denotes	)
T6973	31668-31669	.	denotes	.
T6974	31669-31861	sentence	denotes	Accelerated cartilage maturation and increased expression of Col10a1 was frequently seen in the chondrocytes underlying the articular erosions (Figure 6C and 6D, brackets) (unpublished data).
T6975	31670-31681	VBN	denotes	Accelerated
T6976	31692-31702	NN	denotes	maturation
T6977	31682-31691	NN	denotes	cartilage
T6978	31754-31758	VBN	denotes	seen
T6979	31703-31706	CC	denotes	and
T6980	31707-31716	VBN	denotes	increased
T6981	31717-31727	NN	denotes	expression
T6982	31728-31730	IN	denotes	of
T6983	31731-31738	NN	denotes	Col10a1
T6984	31739-31742	VBD	denotes	was
T6985	31743-31753	RB	denotes	frequently
T6986	31759-31761	IN	denotes	in
T6987	31762-31765	DT	denotes	the
T6988	31766-31778	NNS	denotes	chondrocytes
T6989	31779-31789	VBG	denotes	underlying
T6990	31790-31793	DT	denotes	the
T6991	31804-31812	NNS	denotes	erosions
T6992	31794-31803	JJ	denotes	articular
T6993	31813-31814	-LRB-	denotes	(
T6994	31832-31840	NNS	denotes	brackets
T6995	31814-31820	NN	denotes	Figure
T6996	31821-31823	CD	denotes	6C
T6997	31824-31827	CC	denotes	and
T6998	31828-31830	CD	denotes	6D
T6999	31830-31832	,	denotes	,
T7000	31840-31841	-RRB-	denotes	)
T7001	31842-31843	-LRB-	denotes	(
T7002	31855-31859	NNS	denotes	data
T7003	31843-31854	JJ	denotes	unpublished
T7004	31859-31860	-RRB-	denotes	)
T7005	31860-31861	.	denotes	.
T7006	31861-32001	sentence	denotes	Interestingly, the regions of increased Col10a1 expression did not correspond to the regions that had undergone Cre-mediated recombination.
T7007	31862-31875	RB	denotes	Interestingly
T7008	31929-31939	VB	denotes	correspond
T7009	31875-31877	,	denotes	,
T7010	31877-31880	DT	denotes	the
T7011	31881-31888	NNS	denotes	regions
T7012	31889-31891	IN	denotes	of
T7013	31892-31901	VBN	denotes	increased
T7014	31910-31920	NN	denotes	expression
T7015	31902-31909	NN	denotes	Col10a1
T7016	31921-31924	VBD	denotes	did
T7017	31925-31928	RB	denotes	not
T7018	31940-31942	IN	denotes	to
T7019	31943-31946	DT	denotes	the
T7020	31947-31954	NNS	denotes	regions
T7021	31955-31959	WDT	denotes	that
T7022	31964-31973	VBN	denotes	undergone
T7023	31960-31963	VBD	denotes	had
T7024	31974-31977	NN	denotes	Cre
T7025	31978-31986	VBN	denotes	mediated
T7026	31977-31978	HYPH	denotes	-
T7027	31987-32000	NN	denotes	recombination
T7028	32000-32001	.	denotes	.
T7029	32001-32340	sentence	denotes	Instead, increased expression of Col10a1 was seen in a zone of largely LACZ-negative cells stretching from the cartilage adjacent to the ossification front (where Col10a1 is normally expressed in maturing cartilage cells), toward the regions where surface articular cartilage was severely eroded or missing (Figure 6A and 6B, arrowheads).
T7030	32002-32009	RB	denotes	Instead
T7031	32047-32051	VBN	denotes	seen
T7032	32009-32011	,	denotes	,
T7033	32011-32020	VBN	denotes	increased
T7034	32021-32031	NN	denotes	expression
T7035	32032-32034	IN	denotes	of
T7036	32035-32042	NN	denotes	Col10a1
T7037	32043-32046	VBD	denotes	was
T7038	32052-32054	IN	denotes	in
T7039	32055-32056	DT	denotes	a
T7040	32057-32061	NN	denotes	zone
T7041	32062-32064	IN	denotes	of
T7042	32065-32072	RB	denotes	largely
T7043	32087-32092	NNS	denotes	cells
T7044	32073-32077	NN	denotes	LACZ
T7045	32078-32086	JJ	denotes	negative
T7046	32077-32078	HYPH	denotes	-
T7047	32093-32103	VBG	denotes	stretching
T7048	32104-32108	IN	denotes	from
T7049	32109-32112	DT	denotes	the
T7050	32113-32122	NN	denotes	cartilage
T7051	32123-32131	JJ	denotes	adjacent
T7052	32132-32134	IN	denotes	to
T7053	32135-32138	DT	denotes	the
T7054	32152-32157	NN	denotes	front
T7055	32139-32151	NN	denotes	ossification
T7056	32158-32159	-LRB-	denotes	(
T7057	32159-32164	WRB	denotes	where
T7058	32185-32194	VBN	denotes	expressed
T7059	32165-32172	NN	denotes	Col10a1
T7060	32173-32175	VBZ	denotes	is
T7061	32176-32184	RB	denotes	normally
T7062	32195-32197	IN	denotes	in
T7063	32198-32206	VBG	denotes	maturing
T7064	32217-32222	NNS	denotes	cells
T7065	32207-32216	NN	denotes	cartilage
T7066	32222-32223	-RRB-	denotes	)
T7067	32223-32225	,	denotes	,
T7068	32225-32231	IN	denotes	toward
T7069	32232-32235	DT	denotes	the
T7070	32236-32243	NNS	denotes	regions
T7071	32244-32249	WRB	denotes	where
T7072	32278-32281	VBD	denotes	was
T7073	32250-32257	NN	denotes	surface
T7074	32268-32277	NN	denotes	cartilage
T7075	32258-32267	JJ	denotes	articular
T7076	32282-32290	RB	denotes	severely
T7077	32291-32297	VBN	denotes	eroded
T7078	32298-32300	CC	denotes	or
T7079	32301-32308	VBG	denotes	missing
T7080	32309-32310	-LRB-	denotes	(
T7081	32328-32338	NNS	denotes	arrowheads
T7082	32310-32316	NN	denotes	Figure
T7083	32317-32319	CD	denotes	6A
T7084	32320-32323	CC	denotes	and
T7085	32324-32326	CD	denotes	6B
T7086	32326-32328	,	denotes	,
T7087	32338-32339	-RRB-	denotes	)
T7088	32339-32340	.	denotes	.
T7089	32340-32556	sentence	denotes	Previous studies suggest that parathyroid hormone-related protein, a diffusible signal made in the articular surface, may normally inhibit maturation of underlying cartilage (Vortkamp et al. 1996; Weir et al. 1996).
T7090	32341-32349	JJ	denotes	Previous
T7091	32350-32357	NNS	denotes	studies
T7092	32358-32365	VBP	denotes	suggest
T7093	32366-32370	IN	denotes	that
T7094	32472-32479	VB	denotes	inhibit
T7095	32371-32382	NN	denotes	parathyroid
T7096	32383-32390	NN	denotes	hormone
T7097	32391-32398	VBN	denotes	related
T7098	32390-32391	HYPH	denotes	-
T7099	32399-32406	NN	denotes	protein
T7100	32406-32408	,	denotes	,
T7101	32408-32409	DT	denotes	a
T7102	32421-32427	NN	denotes	signal
T7103	32410-32420	JJ	denotes	diffusible
T7104	32428-32432	VBN	denotes	made
T7105	32433-32435	IN	denotes	in
T7106	32436-32439	DT	denotes	the
T7107	32450-32457	NN	denotes	surface
T7108	32440-32449	JJ	denotes	articular
T7109	32457-32459	,	denotes	,
T7110	32459-32462	MD	denotes	may
T7111	32463-32471	RB	denotes	normally
T7112	32480-32490	NN	denotes	maturation
T7113	32491-32493	IN	denotes	of
T7114	32494-32504	VBG	denotes	underlying
T7115	32505-32514	NN	denotes	cartilage
T7116	32515-32516	-LRB-	denotes	(
T7117	32516-32524	NNP	denotes	Vortkamp
T7118	32525-32527	FW	denotes	et
T7119	32528-32531	FW	denotes	al.
T7120	32532-32536	CD	denotes	1996
T7121	32536-32537	:	denotes	;
T7122	32538-32542	NNP	denotes	Weir
T7123	32543-32545	FW	denotes	et
T7124	32546-32549	FW	denotes	al.
T7125	32550-32554	CD	denotes	1996
T7126	32554-32555	-RRB-	denotes	)
T7127	32555-32556	.	denotes	.
T7128	32556-32737	sentence	denotes	Local loss of the articular surface could remove this inhibition and lead to a cell-nonautonomous acceleration of maturation in chondrocytes underlying points of articular erosion.
T7129	32557-32562	JJ	denotes	Local
T7130	32563-32567	NN	denotes	loss
T7131	32599-32605	VB	denotes	remove
T7132	32568-32570	IN	denotes	of
T7133	32571-32574	DT	denotes	the
T7134	32585-32592	NN	denotes	surface
T7135	32575-32584	JJ	denotes	articular
T7136	32593-32598	MD	denotes	could
T7137	32606-32610	DT	denotes	this
T7138	32611-32621	NN	denotes	inhibition
T7139	32622-32625	CC	denotes	and
T7140	32626-32630	VBP	denotes	lead
T7141	32631-32633	IN	denotes	to
T7142	32634-32635	DT	denotes	a
T7143	32655-32667	NN	denotes	acceleration
T7144	32636-32640	NN	denotes	cell
T7145	32641-32654	JJ	denotes	nonautonomous
T7146	32640-32641	HYPH	denotes	-
T7147	32668-32670	IN	denotes	of
T7148	32671-32681	NN	denotes	maturation
T7149	32682-32684	IN	denotes	in
T7150	32685-32697	NNS	denotes	chondrocytes
T7151	32698-32708	VBG	denotes	underlying
T7152	32709-32715	NNS	denotes	points
T7153	32716-32718	IN	denotes	of
T7154	32719-32728	JJ	denotes	articular
T7155	32729-32736	NN	denotes	erosion
T7156	32736-32737	.	denotes	.
T7157	32737-34030	sentence	denotes	Figure 6 Synovial Membrane Expansion, Articular Surface Erosion, and Accelerated Maturation of Underlying Cartilage in Ankles of Bmpr1a Mutant Mice Near adjacent sections from the tarsal 2-metatarsal II joint of 7-d-old mice. (A and B) LACZ staining (blue) shows Cre-mediated recombination is largely restricted to articular (arrowheads) and synovial cells (asterisks) in both controls and mutants. (C and D) In situ hybridization shows Col10 expression expands in mutants toward regions of synovial membrane expansion and articular surface erosion (brackets and arrows). This may be a cell nonautonomous effect of joint damage, since the LACZ expressing cells at the articular surface do not show upregulation of Col10 (arrowheads) and the region of expanded Col10 expression is largely made up of cells that have not undergone Cre-mediated recombination. Note the formation of a cartilaginous bridge along the joint capsule of the mutant where joint formation is disrupted at earlier stages (B, white arrowhead, and Figure 3, white arrowheads). (A) Scale bar = 75 μm. This synovial hypertrophy is associated with increased numbers of mononuclear cells resembling synoviocytes or macrophages, cell types that are difficult to distinguish even with surface markers at early postnatal stages.
T7158	33809-33813	DT	denotes	This
T7159	33823-33834	NN	denotes	hypertrophy
T7160	33814-33822	JJ	denotes	synovial
T7161	33838-33848	VBN	denotes	associated
T7162	33835-33837	VBZ	denotes	is
T7163	33849-33853	IN	denotes	with
T7164	33854-33863	VBN	denotes	increased
T7165	33864-33871	NNS	denotes	numbers
T7166	33872-33874	IN	denotes	of
T7167	33875-33886	JJ	denotes	mononuclear
T7168	33887-33892	NNS	denotes	cells
T7169	33893-33903	VBG	denotes	resembling
T7170	33904-33916	NNS	denotes	synoviocytes
T7171	33917-33919	CC	denotes	or
T7172	33920-33931	NNS	denotes	macrophages
T7173	33931-33933	,	denotes	,
T7174	33933-33937	NN	denotes	cell
T7175	33938-33943	NNS	denotes	types
T7176	33944-33948	WDT	denotes	that
T7177	33949-33952	VBP	denotes	are
T7178	33953-33962	JJ	denotes	difficult
T7179	33963-33965	TO	denotes	to
T7180	33966-33977	VB	denotes	distinguish
T7181	33978-33982	RB	denotes	even
T7182	33983-33987	IN	denotes	with
T7183	33988-33995	NN	denotes	surface
T7184	33996-34003	NNS	denotes	markers
T7185	34004-34006	IN	denotes	at
T7186	34007-34012	JJ	denotes	early
T7187	34023-34029	NNS	denotes	stages
T7188	34013-34022	JJ	denotes	postnatal
T7189	34029-34030	.	denotes	.
T7190	34030-34115	sentence	denotes	However, no neutrophils were observed, suggesting that there is little inflammation.
T7191	34031-34038	RB	denotes	However
T7192	34060-34068	VBN	denotes	observed
T7193	34038-34040	,	denotes	,
T7194	34040-34042	DT	denotes	no
T7195	34043-34054	NNS	denotes	neutrophils
T7196	34055-34059	VBD	denotes	were
T7197	34068-34070	,	denotes	,
T7198	34070-34080	VBG	denotes	suggesting
T7199	34081-34085	IN	denotes	that
T7200	34092-34094	VBZ	denotes	is
T7201	34086-34091	EX	denotes	there
T7202	34095-34101	JJ	denotes	little
T7203	34102-34114	NN	denotes	inflammation
T7204	34114-34115	.	denotes	.
T7205	34115-34164	sentence	denotes	At later stages synovial hypertrophy is reduced.
T7206	34116-34118	IN	denotes	At
T7207	34156-34163	VBN	denotes	reduced
T7208	34119-34124	JJ	denotes	later
T7209	34125-34131	NNS	denotes	stages
T7210	34132-34140	JJ	denotes	synovial
T7211	34141-34152	NN	denotes	hypertrophy
T7212	34153-34155	VBZ	denotes	is
T7213	34163-34164	.	denotes	.
T7214	34164-34443	sentence	denotes	Further work will be needed to determine whether synovial development is regulated by BMP signaling, or whether the synovium becomes enlarged as a response to nearby skeletal malformations (such as fusion of the second and central tarsals or defects in the articular cartilage).
T7215	34165-34172	JJ	denotes	Further
T7216	34173-34177	NN	denotes	work
T7217	34186-34192	VBN	denotes	needed
T7218	34178-34182	MD	denotes	will
T7219	34183-34185	VB	denotes	be
T7220	34193-34195	TO	denotes	to
T7221	34196-34205	VB	denotes	determine
T7222	34206-34213	IN	denotes	whether
T7223	34238-34247	VBN	denotes	regulated
T7224	34214-34222	JJ	denotes	synovial
T7225	34223-34234	NN	denotes	development
T7226	34235-34237	VBZ	denotes	is
T7227	34248-34250	IN	denotes	by
T7228	34251-34254	NN	denotes	BMP
T7229	34255-34264	NN	denotes	signaling
T7230	34264-34266	,	denotes	,
T7231	34266-34268	CC	denotes	or
T7232	34269-34276	IN	denotes	whether
T7233	34290-34297	VBZ	denotes	becomes
T7234	34277-34280	DT	denotes	the
T7235	34281-34289	NN	denotes	synovium
T7236	34298-34306	VBN	denotes	enlarged
T7237	34307-34309	IN	denotes	as
T7238	34310-34311	DT	denotes	a
T7239	34312-34320	NN	denotes	response
T7240	34321-34323	IN	denotes	to
T7241	34324-34330	JJ	denotes	nearby
T7242	34340-34353	NNS	denotes	malformations
T7243	34331-34339	JJ	denotes	skeletal
T7244	34354-34355	-LRB-	denotes	(
T7245	34355-34359	JJ	denotes	such
T7246	34360-34362	IN	denotes	as
T7247	34363-34369	NN	denotes	fusion
T7248	34370-34372	IN	denotes	of
T7249	34373-34376	DT	denotes	the
T7250	34396-34403	NNS	denotes	tarsals
T7251	34377-34383	JJ	denotes	second
T7252	34384-34387	CC	denotes	and
T7253	34388-34395	JJ	denotes	central
T7254	34404-34406	CC	denotes	or
T7255	34407-34414	NNS	denotes	defects
T7256	34415-34417	IN	denotes	in
T7257	34418-34421	DT	denotes	the
T7258	34432-34441	NN	denotes	cartilage
T7259	34422-34431	JJ	denotes	articular
T7260	34441-34442	-RRB-	denotes	)
T7261	34442-34443	.	denotes	.
T7528	34445-34460	JJ	denotes	Noninflammatory
T7529	34461-34473	NN	denotes	Degeneration
T7530	34474-34476	IN	denotes	of
T7531	34477-34486	JJ	denotes	Articular
T7532	34487-34496	NN	denotes	Cartilage
T7533	34497-34499	IN	denotes	in
T7534	34500-34505	NN	denotes	Digit
T7535	34515-34521	NN	denotes	Joints
T7536	34506-34509	CC	denotes	and
T7537	34510-34514	NN	denotes	Knee
T7538	34521-34621	sentence	denotes	Outside of the ankle region, little or no evidence was seen for expansion of the synovial membrane.
T7539	34522-34529	IN	denotes	Outside
T7540	34577-34581	VBN	denotes	seen
T7541	34530-34532	IN	denotes	of
T7542	34533-34536	DT	denotes	the
T7543	34543-34549	NN	denotes	region
T7544	34537-34542	NN	denotes	ankle
T7545	34549-34551	,	denotes	,
T7546	34551-34557	JJ	denotes	little
T7547	34558-34560	CC	denotes	or
T7548	34561-34563	DT	denotes	no
T7549	34564-34572	NN	denotes	evidence
T7550	34573-34576	VBD	denotes	was
T7551	34582-34585	IN	denotes	for
T7552	34586-34595	NN	denotes	expansion
T7553	34596-34598	IN	denotes	of
T7554	34599-34602	DT	denotes	the
T7555	34612-34620	NN	denotes	membrane
T7556	34603-34611	JJ	denotes	synovial
T7557	34620-34621	.	denotes	.
T7558	34621-34745	sentence	denotes	Instead, mutant mice showed histological signs of osteoarthritis, such as fibrillation of the articular surface (Figure 7).
T7559	34622-34629	RB	denotes	Instead
T7560	34643-34649	VBD	denotes	showed
T7561	34629-34631	,	denotes	,
T7562	34631-34637	NN	denotes	mutant
T7563	34638-34642	NNS	denotes	mice
T7564	34650-34662	JJ	denotes	histological
T7565	34663-34668	NNS	denotes	signs
T7566	34669-34671	IN	denotes	of
T7567	34672-34686	NN	denotes	osteoarthritis
T7568	34686-34688	,	denotes	,
T7569	34688-34692	JJ	denotes	such
T7570	34693-34695	IN	denotes	as
T7571	34696-34708	NN	denotes	fibrillation
T7572	34709-34711	IN	denotes	of
T7573	34712-34715	DT	denotes	the
T7574	34726-34733	NN	denotes	surface
T7575	34716-34725	JJ	denotes	articular
T7576	34734-34735	-LRB-	denotes	(
T7577	34735-34741	NN	denotes	Figure
T7578	34742-34743	CD	denotes	7
T7579	34743-34744	-RRB-	denotes	)
T7580	34744-34745	.	denotes	.
T7581	34745-35007	sentence	denotes	As previously seen in 1- and 2-wk-old animals, Safranin O staining and Agg and Col10 expression were all reduced in mutant articular regions of the forefeet and hindfeet by 7 wk of age, and the beginning signs of cartilage loss were observed (unpublished data).
T7582	34746-34748	IN	denotes	As
T7583	34760-34764	VBN	denotes	seen
T7584	34749-34759	RB	denotes	previously
T7585	34851-34858	VBN	denotes	reduced
T7586	34765-34767	IN	denotes	in
T7587	34768-34769	CD	denotes	1
T7588	34777-34779	NN	denotes	wk
T7589	34769-34770	HYPH	denotes	-
T7590	34771-34774	CC	denotes	and
T7591	34775-34776	CD	denotes	2
T7592	34776-34777	HYPH	denotes	-
T7593	34780-34783	JJ	denotes	old
T7594	34779-34780	HYPH	denotes	-
T7595	34784-34791	NNS	denotes	animals
T7596	34791-34793	,	denotes	,
T7597	34793-34801	NN	denotes	Safranin
T7598	34802-34803	NN	denotes	O
T7599	34804-34812	NN	denotes	staining
T7600	34813-34816	CC	denotes	and
T7601	34817-34820	NN	denotes	Agg
T7602	34831-34841	NN	denotes	expression
T7603	34821-34824	CC	denotes	and
T7604	34825-34830	NN	denotes	Col10
T7605	34842-34846	VBD	denotes	were
T7606	34847-34850	RB	denotes	all
T7607	34859-34861	IN	denotes	in
T7608	34862-34868	NN	denotes	mutant
T7609	34879-34886	NNS	denotes	regions
T7610	34869-34878	JJ	denotes	articular
T7611	34887-34889	IN	denotes	of
T7612	34890-34893	DT	denotes	the
T7613	34894-34902	NNS	denotes	forefeet
T7614	34903-34906	CC	denotes	and
T7615	34907-34915	NN	denotes	hindfeet
T7616	34916-34918	IN	denotes	by
T7617	34919-34920	CD	denotes	7
T7618	34921-34923	NN	denotes	wk
T7619	34924-34926	IN	denotes	of
T7620	34927-34930	NN	denotes	age
T7621	34930-34932	,	denotes	,
T7622	34932-34935	CC	denotes	and
T7623	34936-34939	DT	denotes	the
T7624	34950-34955	NNS	denotes	signs
T7625	34940-34949	NN	denotes	beginning
T7626	34979-34987	VBN	denotes	observed
T7627	34956-34958	IN	denotes	of
T7628	34959-34968	NN	denotes	cartilage
T7629	34969-34973	NN	denotes	loss
T7630	34974-34978	VBD	denotes	were
T7631	34988-34989	-LRB-	denotes	(
T7632	35001-35005	NNS	denotes	data
T7633	34989-35000	JJ	denotes	unpublished
T7634	35005-35006	-RRB-	denotes	)
T7635	35006-35007	.	denotes	.
T7636	35007-35172	sentence	denotes	By 9 mo of age, many regions of articular cartilage were completely missing or extremely fibrillated, leaving regions of exposed bone on the surface (Figure 7A–7D).
T7637	35008-35010	IN	denotes	By
T7638	35060-35064	VBD	denotes	were
T7639	35011-35012	CD	denotes	9
T7640	35013-35015	NN	denotes	mo
T7641	35016-35018	IN	denotes	of
T7642	35019-35022	NN	denotes	age
T7643	35022-35024	,	denotes	,
T7644	35024-35028	JJ	denotes	many
T7645	35029-35036	NNS	denotes	regions
T7646	35037-35039	IN	denotes	of
T7647	35040-35049	JJ	denotes	articular
T7648	35050-35059	NN	denotes	cartilage
T7649	35065-35075	RB	denotes	completely
T7650	35076-35083	VBG	denotes	missing
T7651	35084-35086	CC	denotes	or
T7652	35087-35096	RB	denotes	extremely
T7653	35097-35108	VBN	denotes	fibrillated
T7654	35108-35110	,	denotes	,
T7655	35110-35117	VBG	denotes	leaving
T7656	35118-35125	NNS	denotes	regions
T7657	35126-35128	IN	denotes	of
T7658	35129-35136	VBN	denotes	exposed
T7659	35137-35141	NN	denotes	bone
T7660	35142-35144	IN	denotes	on
T7661	35145-35148	DT	denotes	the
T7662	35149-35156	NN	denotes	surface
T7663	35157-35158	-LRB-	denotes	(
T7664	35165-35167	CD	denotes	7A
T7665	35158-35164	NN	denotes	Figure
T7666	35167-35168	SYM	denotes	–
T7667	35168-35170	CD	denotes	7D
T7668	35170-35171	-RRB-	denotes	)
T7669	35171-35172	.	denotes	.
T7670	35172-35292	sentence	denotes	No alterations were seen in the expression of Osteocalcin, Col1a1, or matrix metalloprotease-13 at either 7 wk or 9 mo.
T7671	35173-35175	DT	denotes	No
T7672	35176-35187	NNS	denotes	alterations
T7673	35193-35197	VBN	denotes	seen
T7674	35188-35192	VBD	denotes	were
T7675	35198-35200	IN	denotes	in
T7676	35201-35204	DT	denotes	the
T7677	35205-35215	NN	denotes	expression
T7678	35216-35218	IN	denotes	of
T7679	35219-35230	NN	denotes	Osteocalcin
T7680	35230-35232	,	denotes	,
T7681	35232-35238	NN	denotes	Col1a1
T7682	35238-35240	,	denotes	,
T7683	35240-35242	CC	denotes	or
T7684	35243-35249	NN	denotes	matrix
T7685	35250-35265	NN	denotes	metalloprotease
T7686	35265-35266	HYPH	denotes	-
T7687	35266-35268	CD	denotes	13
T7688	35269-35271	IN	denotes	at
T7689	35272-35278	CC	denotes	either
T7690	35281-35283	NNS	denotes	wk
T7691	35279-35280	CD	denotes	7
T7692	35284-35286	CC	denotes	or
T7693	35287-35288	CD	denotes	9
T7694	35289-35291	NNS	denotes	mo
T7695	35291-35292	.	denotes	.
T7696	35292-37146	sentence	denotes	Figure 7 Loss of Bmpr1a Signaling Leads to Articular Cartilage Fibrillation and Degeneration in Digits and Knees of Aging Mice (A–D) Near adjacent sections of metatarsal-phalangeal joints from 9 month old mice. Articular cartilage of controls is complete and stains strongly with Safranin O (A, orange stain). In contrast, articular cells of mutants are severely fibrillated or absent with much reduced staining of Safranin O (C, arrowheads). LACZ expression confirms Cre-mediated recombination has occurred in articular cells (B and D). (E–P) Sagittal sections through knee joints of 7-wk- (E–J) or 9-mo-old animals (K–P); fe, femur; ti, tibia; gp, growth plate. Seven weeks after birth, the height of the tibial epiphysis is reduced in mutants (E and H, bars), and their articular layer stains poorly with Safranin O, is fibrillated, and is strikingly thinner (F and I, black arrowhead, and brackets). Near adjacent sections with LACZ staining confirm Cre-mediated recombination has occurred in articular cells (G and J). Note that in mutants, LACZ is absent in cells adjacent to those that do stain with Safranin O, suggesting Bmpr1a may act cell autonomously (I and J, white arrowheads). At 9 mo old, the mutant tibial epiphysis is extremely thin (K and N, bars), and the articular layer is completely absent, leaving bone to rub directly on bone (L and O, bracket). LACZ staining shows Cre-mediated recombination occurred in articular cells of controls (M) and in some remaining skeletal tissue of mutants (P). Also note aberrantly formed meniscal cartilage in mutants (E, H, K, and N, arrows), and increased sclerosis in mutant epiphyses (E, H, K, and N, asterisks). (A and K) Scale bar = 50 μm; (I) scale bar = 300 μm. The major weight-bearing joint of the hindlimb, the knee, showed changes that closely paralleled that seen in the foot joints.
T7697	37020-37023	DT	denotes	The
T7698	37045-37050	NN	denotes	joint
T7699	37024-37029	JJ	denotes	major
T7700	37030-37036	NN	denotes	weight
T7701	37036-37037	HYPH	denotes	-
T7702	37037-37044	VBG	denotes	bearing
T7703	37078-37084	VBD	denotes	showed
T7704	37051-37053	IN	denotes	of
T7705	37054-37057	DT	denotes	the
T7706	37058-37066	NN	denotes	hindlimb
T7707	37066-37068	,	denotes	,
T7708	37068-37071	DT	denotes	the
T7709	37072-37076	NN	denotes	knee
T7710	37076-37078	,	denotes	,
T7711	37085-37092	NNS	denotes	changes
T7712	37093-37097	WDT	denotes	that
T7713	37106-37116	VBD	denotes	paralleled
T7714	37098-37105	RB	denotes	closely
T7715	37117-37121	DT	denotes	that
T7716	37122-37126	VBN	denotes	seen
T7717	37127-37129	IN	denotes	in
T7718	37130-37133	DT	denotes	the
T7719	37139-37145	NNS	denotes	joints
T7720	37134-37138	NN	denotes	foot
T7721	37145-37146	.	denotes	.
T7722	37146-37302	sentence	denotes	All markers of cartilage matrix looked similar to controls at E16.5, suggesting that early stages of joint formation were not disrupted (unpublished data).
T7723	37147-37150	DT	denotes	All
T7724	37151-37158	NNS	denotes	markers
T7725	37179-37185	VBD	denotes	looked
T7726	37159-37161	IN	denotes	of
T7727	37162-37171	NN	denotes	cartilage
T7728	37172-37178	NN	denotes	matrix
T7729	37186-37193	JJ	denotes	similar
T7730	37194-37196	IN	denotes	to
T7731	37197-37205	NNS	denotes	controls
T7732	37206-37208	IN	denotes	at
T7733	37209-37214	NN	denotes	E16.5
T7734	37214-37216	,	denotes	,
T7735	37216-37226	VBG	denotes	suggesting
T7736	37227-37231	IN	denotes	that
T7737	37273-37282	VBN	denotes	disrupted
T7738	37232-37237	JJ	denotes	early
T7739	37238-37244	NNS	denotes	stages
T7740	37245-37247	IN	denotes	of
T7741	37248-37253	NN	denotes	joint
T7742	37254-37263	NN	denotes	formation
T7743	37264-37268	VBD	denotes	were
T7744	37269-37272	RB	denotes	not
T7745	37283-37284	-LRB-	denotes	(
T7746	37296-37300	NNS	denotes	data
T7747	37284-37295	JJ	denotes	unpublished
T7748	37300-37301	-RRB-	denotes	)
T7749	37301-37302	.	denotes	.
T7750	37302-37465	sentence	denotes	By postnatal day 7, Safranin O staining and Col2a1 and Agg expression were clearly reduced in the mutant, despite continued expression of Sox9 (unpublished data).
T7751	37303-37305	IN	denotes	By
T7752	37386-37393	VBN	denotes	reduced
T7753	37306-37315	JJ	denotes	postnatal
T7754	37316-37319	NN	denotes	day
T7755	37320-37321	CD	denotes	7
T7756	37321-37323	,	denotes	,
T7757	37323-37331	NN	denotes	Safranin
T7758	37332-37333	NN	denotes	O
T7759	37334-37342	NN	denotes	staining
T7760	37343-37346	CC	denotes	and
T7761	37347-37353	NN	denotes	Col2a1
T7762	37362-37372	NN	denotes	expression
T7763	37354-37357	CC	denotes	and
T7764	37358-37361	NN	denotes	Agg
T7765	37373-37377	VBD	denotes	were
T7766	37378-37385	RB	denotes	clearly
T7767	37394-37396	IN	denotes	in
T7768	37397-37400	DT	denotes	the
T7769	37401-37407	NN	denotes	mutant
T7770	37407-37409	,	denotes	,
T7771	37409-37416	IN	denotes	despite
T7772	37417-37426	VBN	denotes	continued
T7773	37427-37437	NN	denotes	expression
T7774	37438-37440	IN	denotes	of
T7775	37441-37445	NN	denotes	Sox9
T7776	37446-37447	-LRB-	denotes	(
T7777	37459-37463	NNS	denotes	data
T7778	37447-37458	JJ	denotes	unpublished
T7779	37463-37464	-RRB-	denotes	)
T7780	37464-37465	.	denotes	.
T7781	37465-37674	sentence	denotes	The overall shape of mutant knee skeletal elements appeared similar to controls, although the fibrocartilaginous meniscus that resides between the femur and tibia appeared much less dense in mutants at E16.5.
T7782	37466-37469	DT	denotes	The
T7783	37478-37483	NN	denotes	shape
T7784	37470-37477	JJ	denotes	overall
T7785	37517-37525	VBD	denotes	appeared
T7786	37484-37486	IN	denotes	of
T7787	37487-37493	NN	denotes	mutant
T7788	37494-37498	NN	denotes	knee
T7789	37508-37516	NNS	denotes	elements
T7790	37499-37507	JJ	denotes	skeletal
T7791	37526-37533	JJ	denotes	similar
T7792	37534-37536	IN	denotes	to
T7793	37537-37545	NNS	denotes	controls
T7794	37545-37547	,	denotes	,
T7795	37547-37555	IN	denotes	although
T7796	37629-37637	VBD	denotes	appeared
T7797	37556-37559	DT	denotes	the
T7798	37579-37587	NN	denotes	meniscus
T7799	37560-37578	NN	denotes	fibrocartilaginous
T7800	37588-37592	WDT	denotes	that
T7801	37593-37600	VBZ	denotes	resides
T7802	37601-37608	IN	denotes	between
T7803	37609-37612	DT	denotes	the
T7804	37613-37618	NN	denotes	femur
T7805	37619-37622	CC	denotes	and
T7806	37623-37628	NN	denotes	tibia
T7807	37638-37642	RB	denotes	much
T7808	37643-37647	RBR	denotes	less
T7809	37648-37653	JJ	denotes	dense
T7810	37654-37656	IN	denotes	in
T7811	37657-37664	NNS	denotes	mutants
T7812	37665-37667	IN	denotes	at
T7813	37668-37673	NN	denotes	E16.5
T7814	37673-37674	.	denotes	.
T7815	37674-37862	sentence	denotes	Some cartilage formed in the meniscus region, but the size of these elements was greatly reduced and contained abundant cells with fibrous, noncartilaginous appearance (unpublished data).
T7816	37675-37679	DT	denotes	Some
T7817	37680-37689	NN	denotes	cartilage
T7818	37690-37696	VBN	denotes	formed
T7819	37697-37699	IN	denotes	in
T7820	37700-37703	DT	denotes	the
T7821	37713-37719	NN	denotes	region
T7822	37704-37712	NN	denotes	meniscus
T7823	37719-37721	,	denotes	,
T7824	37721-37724	CC	denotes	but
T7825	37725-37728	DT	denotes	the
T7826	37729-37733	NN	denotes	size
T7827	37764-37771	VBN	denotes	reduced
T7828	37734-37736	IN	denotes	of
T7829	37737-37742	DT	denotes	these
T7830	37743-37751	NNS	denotes	elements
T7831	37752-37755	VBD	denotes	was
T7832	37756-37763	RB	denotes	greatly
T7833	37772-37775	CC	denotes	and
T7834	37776-37785	VBN	denotes	contained
T7835	37786-37794	JJ	denotes	abundant
T7836	37795-37800	NNS	denotes	cells
T7837	37801-37805	IN	denotes	with
T7838	37806-37813	JJ	denotes	fibrous
T7839	37832-37842	NN	denotes	appearance
T7840	37813-37815	,	denotes	,
T7841	37815-37831	JJ	denotes	noncartilaginous
T7842	37843-37844	-LRB-	denotes	(
T7843	37856-37860	NNS	denotes	data
T7844	37844-37855	JJ	denotes	unpublished
T7845	37860-37861	-RRB-	denotes	)
T7846	37861-37862	.	denotes	.
T7847	37862-37991	sentence	denotes	This reduction of the meniscus can also be seen in sections from 7-wk- and 9-mo-old animals (Figure 7E, 7H, 7K, and 7N, arrows).
T7848	37863-37867	DT	denotes	This
T7849	37868-37877	NN	denotes	reduction
T7850	37906-37910	VBN	denotes	seen
T7851	37878-37880	IN	denotes	of
T7852	37881-37884	DT	denotes	the
T7853	37885-37893	NN	denotes	meniscus
T7854	37894-37897	MD	denotes	can
T7855	37898-37902	RB	denotes	also
T7856	37903-37905	VB	denotes	be
T7857	37911-37913	IN	denotes	in
T7858	37914-37922	NNS	denotes	sections
T7859	37923-37927	IN	denotes	from
T7860	37928-37929	CD	denotes	7
T7861	37930-37932	NN	denotes	wk
T7862	37929-37930	HYPH	denotes	-
T7863	37943-37946	JJ	denotes	old
T7864	37932-37933	HYPH	denotes	-
T7865	37934-37937	CC	denotes	and
T7866	37938-37939	CD	denotes	9
T7867	37940-37942	NN	denotes	mo
T7868	37939-37940	HYPH	denotes	-
T7869	37942-37943	HYPH	denotes	-
T7870	37947-37954	NNS	denotes	animals
T7871	37955-37956	-LRB-	denotes	(
T7872	37983-37989	NNS	denotes	arrows
T7873	37956-37962	NN	denotes	Figure
T7874	37963-37965	CD	denotes	7E
T7875	37965-37967	,	denotes	,
T7876	37967-37969	CD	denotes	7H
T7877	37969-37971	,	denotes	,
T7878	37971-37973	CD	denotes	7K
T7879	37973-37975	,	denotes	,
T7880	37975-37978	CC	denotes	and
T7881	37979-37981	CD	denotes	7N
T7882	37981-37983	,	denotes	,
T7883	37989-37990	-RRB-	denotes	)
T7884	37990-37991	.	denotes	.
T7885	37991-38214	sentence	denotes	At 7 wk of age the normally domed tibial epiphysis was flattened and depressed in the knees of mutant animals, markedly reducing the distance between the growth plate and articular surface (Figure 7E and 7H, vertical bar).
T7886	37992-37994	IN	denotes	At
T7887	38047-38056	VBN	denotes	flattened
T7888	37995-37996	CD	denotes	7
T7889	37997-37999	NNS	denotes	wk
T7890	38000-38002	IN	denotes	of
T7891	38003-38006	NN	denotes	age
T7892	38007-38010	DT	denotes	the
T7893	38033-38042	NN	denotes	epiphysis
T7894	38011-38019	RB	denotes	normally
T7895	38020-38025	VBN	denotes	domed
T7896	38026-38032	JJ	denotes	tibial
T7897	38043-38046	VBD	denotes	was
T7898	38057-38060	CC	denotes	and
T7899	38061-38070	VBN	denotes	depressed
T7900	38071-38073	IN	denotes	in
T7901	38074-38077	DT	denotes	the
T7902	38078-38083	NNS	denotes	knees
T7903	38084-38086	IN	denotes	of
T7904	38087-38093	NN	denotes	mutant
T7905	38094-38101	NNS	denotes	animals
T7906	38101-38103	,	denotes	,
T7907	38103-38111	RB	denotes	markedly
T7908	38112-38120	VBG	denotes	reducing
T7909	38121-38124	DT	denotes	the
T7910	38125-38133	NN	denotes	distance
T7911	38134-38141	IN	denotes	between
T7912	38142-38145	DT	denotes	the
T7913	38153-38158	NN	denotes	plate
T7914	38146-38152	NN	denotes	growth
T7915	38159-38162	CC	denotes	and
T7916	38163-38172	JJ	denotes	articular
T7917	38173-38180	NN	denotes	surface
T7918	38181-38182	-LRB-	denotes	(
T7919	38209-38212	NN	denotes	bar
T7920	38182-38188	NN	denotes	Figure
T7921	38189-38191	CD	denotes	7E
T7922	38192-38195	CC	denotes	and
T7923	38196-38198	CD	denotes	7H
T7924	38198-38200	,	denotes	,
T7925	38200-38208	JJ	denotes	vertical
T7926	38212-38213	-RRB-	denotes	)
T7927	38213-38214	.	denotes	.
T7928	38214-38419	sentence	denotes	Articular cartilage was also thinner than in control animals, showed nearly complete absence of Safranin O staining, and was either acellular or beginning to fibrillate in many regions (Figure 7F and 7I).
T7929	38215-38224	JJ	denotes	Articular
T7930	38225-38234	NN	denotes	cartilage
T7931	38235-38238	VBD	denotes	was
T7932	38239-38243	RB	denotes	also
T7933	38244-38251	JJR	denotes	thinner
T7934	38252-38256	IN	denotes	than
T7935	38257-38259	IN	denotes	in
T7936	38260-38267	NN	denotes	control
T7937	38268-38275	NNS	denotes	animals
T7938	38275-38277	,	denotes	,
T7939	38277-38283	VBD	denotes	showed
T7940	38284-38290	RB	denotes	nearly
T7941	38291-38299	JJ	denotes	complete
T7942	38300-38307	NN	denotes	absence
T7943	38308-38310	IN	denotes	of
T7944	38311-38319	NN	denotes	Safranin
T7945	38320-38321	NN	denotes	O
T7946	38322-38330	NN	denotes	staining
T7947	38330-38332	,	denotes	,
T7948	38332-38335	CC	denotes	and
T7949	38336-38339	VBD	denotes	was
T7950	38340-38346	CC	denotes	either
T7951	38347-38356	JJ	denotes	acellular
T7952	38357-38359	CC	denotes	or
T7953	38360-38369	VBG	denotes	beginning
T7954	38370-38372	TO	denotes	to
T7955	38373-38383	VB	denotes	fibrillate
T7956	38384-38386	IN	denotes	in
T7957	38387-38391	JJ	denotes	many
T7958	38392-38399	NNS	denotes	regions
T7959	38400-38401	-LRB-	denotes	(
T7960	38401-38407	NN	denotes	Figure
T7961	38408-38410	CD	denotes	7F
T7962	38411-38414	CC	denotes	and
T7963	38415-38417	CD	denotes	7I
T7964	38417-38418	-RRB-	denotes	)
T7965	38418-38419	.	denotes	.
T7966	38419-38700	sentence	denotes	The few large Safranin O-stained cells still apparent in mutant articular regions appeared to correspond in position to rare LACZ-negative cells in adjacent sections, suggesting that Bmpr1a is required cell-autonomously in articular cartilage (Figure 7I and 7J, white arrowheads).
T7967	38420-38423	DT	denotes	The
T7968	38453-38458	NNS	denotes	cells
T7969	38424-38427	JJ	denotes	few
T7970	38428-38433	JJ	denotes	large
T7971	38434-38442	NN	denotes	Safranin
T7972	38443-38444	NN	denotes	O
T7973	38445-38452	VBN	denotes	stained
T7974	38444-38445	HYPH	denotes	-
T7975	38502-38510	VBD	denotes	appeared
T7976	38459-38464	RB	denotes	still
T7977	38465-38473	JJ	denotes	apparent
T7978	38474-38476	IN	denotes	in
T7979	38477-38483	NN	denotes	mutant
T7980	38494-38501	NNS	denotes	regions
T7981	38484-38493	JJ	denotes	articular
T7982	38511-38513	TO	denotes	to
T7983	38514-38524	VB	denotes	correspond
T7984	38525-38527	IN	denotes	in
T7985	38528-38536	NN	denotes	position
T7986	38537-38539	IN	denotes	to
T7987	38540-38544	JJ	denotes	rare
T7988	38559-38564	NNS	denotes	cells
T7989	38545-38549	NN	denotes	LACZ
T7990	38550-38558	JJ	denotes	negative
T7991	38549-38550	HYPH	denotes	-
T7992	38565-38567	IN	denotes	in
T7993	38568-38576	JJ	denotes	adjacent
T7994	38577-38585	NNS	denotes	sections
T7995	38585-38587	,	denotes	,
T7996	38587-38597	VBG	denotes	suggesting
T7997	38598-38602	IN	denotes	that
T7998	38613-38621	VBN	denotes	required
T7999	38603-38609	NN	denotes	Bmpr1a
T8000	38610-38612	VBZ	denotes	is
T8001	38622-38626	NN	denotes	cell
T8002	38627-38639	RB	denotes	autonomously
T8003	38626-38627	HYPH	denotes	-
T8004	38640-38642	IN	denotes	in
T8005	38643-38652	JJ	denotes	articular
T8006	38653-38662	NN	denotes	cartilage
T8007	38663-38664	-LRB-	denotes	(
T8008	38688-38698	NNS	denotes	arrowheads
T8009	38664-38670	NN	denotes	Figure
T8010	38671-38673	CD	denotes	7I
T8011	38674-38677	CC	denotes	and
T8012	38678-38680	CD	denotes	7J
T8013	38680-38682	,	denotes	,
T8014	38682-38687	JJ	denotes	white
T8015	38698-38699	-RRB-	denotes	)
T8016	38699-38700	.	denotes	.
T8017	38700-38851	sentence	denotes	By 9 mo, large areas of mutant knees were devoid of articular cells, and the bones of the femur and tibia appeared to rub directly against each other.
T8018	38701-38703	IN	denotes	By
T8019	38738-38742	VBD	denotes	were
T8020	38704-38705	CD	denotes	9
T8021	38706-38708	NN	denotes	mo
T8022	38708-38710	,	denotes	,
T8023	38710-38715	JJ	denotes	large
T8024	38716-38721	NNS	denotes	areas
T8025	38722-38724	IN	denotes	of
T8026	38725-38731	NN	denotes	mutant
T8027	38732-38737	NNS	denotes	knees
T8028	38743-38749	JJ	denotes	devoid
T8029	38750-38752	IN	denotes	of
T8030	38753-38762	JJ	denotes	articular
T8031	38763-38768	NNS	denotes	cells
T8032	38768-38770	,	denotes	,
T8033	38770-38773	CC	denotes	and
T8034	38774-38777	DT	denotes	the
T8035	38778-38783	NNS	denotes	bones
T8036	38807-38815	VBD	denotes	appeared
T8037	38784-38786	IN	denotes	of
T8038	38787-38790	DT	denotes	the
T8039	38791-38796	NN	denotes	femur
T8040	38797-38800	CC	denotes	and
T8041	38801-38806	NN	denotes	tibia
T8042	38816-38818	TO	denotes	to
T8043	38819-38822	VB	denotes	rub
T8044	38823-38831	RB	denotes	directly
T8045	38832-38839	IN	denotes	against
T8046	38840-38844	DT	denotes	each
T8047	38845-38850	JJ	denotes	other
T8048	38850-38851	.	denotes	.
T8049	38851-39037	sentence	denotes	Furthermore, the epiphysis of the tibia was extremely depressed, to the point that growth plate cartilage was almost exposed through the surface of the bone (Figure 7K, 7L, 7N, and 7O).
T8050	38852-38863	RB	denotes	Furthermore
T8051	38892-38895	VBD	denotes	was
T8052	38863-38865	,	denotes	,
T8053	38865-38868	DT	denotes	the
T8054	38869-38878	NN	denotes	epiphysis
T8055	38879-38881	IN	denotes	of
T8056	38882-38885	DT	denotes	the
T8057	38886-38891	NN	denotes	tibia
T8058	38896-38905	RB	denotes	extremely
T8059	38906-38915	JJ	denotes	depressed
T8060	38915-38917	,	denotes	,
T8061	38917-38919	IN	denotes	to
T8062	38920-38923	DT	denotes	the
T8063	38924-38929	NN	denotes	point
T8064	38930-38934	IN	denotes	that
T8065	38969-38976	VBN	denotes	exposed
T8066	38935-38941	NN	denotes	growth
T8067	38948-38957	NN	denotes	cartilage
T8068	38942-38947	NN	denotes	plate
T8069	38958-38961	VBD	denotes	was
T8070	38962-38968	RB	denotes	almost
T8071	38977-38984	IN	denotes	through
T8072	38985-38988	DT	denotes	the
T8073	38989-38996	NN	denotes	surface
T8074	38997-38999	IN	denotes	of
T8075	39000-39003	DT	denotes	the
T8076	39004-39008	NN	denotes	bone
T8077	39009-39010	-LRB-	denotes	(
T8078	39017-39019	CD	denotes	7K
T8079	39010-39016	NN	denotes	Figure
T8080	39019-39021	,	denotes	,
T8081	39021-39023	CD	denotes	7L
T8082	39023-39025	,	denotes	,
T8083	39025-39027	CD	denotes	7N
T8084	39027-39029	,	denotes	,
T8085	39029-39032	CC	denotes	and
T8086	39033-39035	CD	denotes	7O
T8087	39035-39036	-RRB-	denotes	)
T8088	39036-39037	.	denotes	.
T8089	39037-39186	sentence	denotes	In addition, mutants at 7 wk and 9 mo showed subchondral sclerosis, especially in the epiphysis of the femur (Figure 7E, 7H, 7K, and 7N, asterisks).
T8090	39038-39040	IN	denotes	In
T8091	39076-39082	VBD	denotes	showed
T8092	39041-39049	NN	denotes	addition
T8093	39049-39051	,	denotes	,
T8094	39051-39058	NNS	denotes	mutants
T8095	39059-39061	IN	denotes	at
T8096	39062-39063	CD	denotes	7
T8097	39064-39066	NNS	denotes	wk
T8098	39067-39070	CC	denotes	and
T8099	39071-39072	CD	denotes	9
T8100	39073-39075	NNS	denotes	mo
T8101	39083-39094	JJ	denotes	subchondral
T8102	39095-39104	NN	denotes	sclerosis
T8103	39104-39106	,	denotes	,
T8104	39106-39116	RB	denotes	especially
T8105	39117-39119	IN	denotes	in
T8106	39120-39123	DT	denotes	the
T8107	39124-39133	NN	denotes	epiphysis
T8108	39134-39136	IN	denotes	of
T8109	39137-39140	DT	denotes	the
T8110	39141-39146	NN	denotes	femur
T8111	39147-39148	-LRB-	denotes	(
T8112	39175-39184	NNS	denotes	asterisks
T8113	39148-39154	NN	denotes	Figure
T8114	39155-39157	CD	denotes	7E
T8115	39157-39159	,	denotes	,
T8116	39159-39161	CD	denotes	7H
T8117	39161-39163	,	denotes	,
T8118	39163-39165	CD	denotes	7K
T8119	39165-39167	,	denotes	,
T8120	39167-39170	CC	denotes	and
T8121	39171-39173	CD	denotes	7N
T8122	39173-39175	,	denotes	,
T8123	39184-39185	-RRB-	denotes	)
T8124	39185-39186	.	denotes	.
T8125	39186-39540	sentence	denotes	While subchondral sclerosis is commonly seen in cases of osteoarthritis, it is unclear in this case whether the sclerosis is mainly a response of bone formation to compensate for decreased articular cartilage, or whether it is the effect of loss of Bmpr1a signaling in some LACZ-positive cells that are also observed in these regions (unpublished data).
T8126	39187-39192	IN	denotes	While
T8127	39227-39231	VBN	denotes	seen
T8128	39193-39204	JJ	denotes	subchondral
T8129	39205-39214	NN	denotes	sclerosis
T8130	39215-39217	VBZ	denotes	is
T8131	39218-39226	RB	denotes	commonly
T8132	39263-39265	VBZ	denotes	is
T8133	39232-39234	IN	denotes	in
T8134	39235-39240	NNS	denotes	cases
T8135	39241-39243	IN	denotes	of
T8136	39244-39258	NN	denotes	osteoarthritis
T8137	39258-39260	,	denotes	,
T8138	39260-39262	PRP	denotes	it
T8139	39266-39273	JJ	denotes	unclear
T8140	39274-39276	IN	denotes	in
T8141	39277-39281	DT	denotes	this
T8142	39282-39286	NN	denotes	case
T8143	39287-39294	IN	denotes	whether
T8144	39309-39311	VBZ	denotes	is
T8145	39295-39298	DT	denotes	the
T8146	39299-39308	NN	denotes	sclerosis
T8147	39312-39318	RB	denotes	mainly
T8148	39319-39320	DT	denotes	a
T8149	39321-39329	NN	denotes	response
T8150	39330-39332	IN	denotes	of
T8151	39333-39337	NN	denotes	bone
T8152	39338-39347	NN	denotes	formation
T8153	39348-39350	TO	denotes	to
T8154	39351-39361	VB	denotes	compensate
T8155	39362-39365	IN	denotes	for
T8156	39366-39375	VBN	denotes	decreased
T8157	39386-39395	NN	denotes	cartilage
T8158	39376-39385	JJ	denotes	articular
T8159	39395-39397	,	denotes	,
T8160	39397-39399	CC	denotes	or
T8161	39400-39407	IN	denotes	whether
T8162	39411-39413	VBZ	denotes	is
T8163	39408-39410	PRP	denotes	it
T8164	39414-39417	DT	denotes	the
T8165	39418-39424	NN	denotes	effect
T8166	39425-39427	IN	denotes	of
T8167	39428-39432	NN	denotes	loss
T8168	39433-39435	IN	denotes	of
T8169	39436-39442	NN	denotes	Bmpr1a
T8170	39443-39452	NN	denotes	signaling
T8171	39453-39455	IN	denotes	in
T8172	39456-39460	DT	denotes	some
T8173	39475-39480	NNS	denotes	cells
T8174	39461-39465	NN	denotes	LACZ
T8175	39466-39474	JJ	denotes	positive
T8176	39465-39466	HYPH	denotes	-
T8177	39481-39485	WDT	denotes	that
T8178	39495-39503	VBN	denotes	observed
T8179	39486-39489	VBP	denotes	are
T8180	39490-39494	RB	denotes	also
T8181	39504-39506	IN	denotes	in
T8182	39507-39512	DT	denotes	these
T8183	39513-39520	NNS	denotes	regions
T8184	39521-39522	-LRB-	denotes	(
T8185	39534-39538	NNS	denotes	data
T8186	39522-39533	JJ	denotes	unpublished
T8187	39538-39539	-RRB-	denotes	)
T8188	39539-39540	.	denotes	.
T8189	39540-39689	sentence	denotes	The histological signs of joint arthritis were accompanied by functional impairments in both grasping ability and range of motion in mutant animals.
T8190	39541-39544	DT	denotes	The
T8191	39558-39563	NNS	denotes	signs
T8192	39545-39557	JJ	denotes	histological
T8193	39588-39599	VBN	denotes	accompanied
T8194	39564-39566	IN	denotes	of
T8195	39567-39572	NN	denotes	joint
T8196	39573-39582	NN	denotes	arthritis
T8197	39583-39587	VBD	denotes	were
T8198	39600-39602	IN	denotes	by
T8199	39603-39613	JJ	denotes	functional
T8200	39614-39625	NNS	denotes	impairments
T8201	39626-39628	IN	denotes	in
T8202	39629-39633	CC	denotes	both
T8203	39643-39650	NN	denotes	ability
T8204	39634-39642	VBG	denotes	grasping
T8205	39651-39654	CC	denotes	and
T8206	39655-39660	NN	denotes	range
T8207	39661-39663	IN	denotes	of
T8208	39664-39670	NN	denotes	motion
T8209	39671-39673	IN	denotes	in
T8210	39674-39680	NN	denotes	mutant
T8211	39681-39688	NNS	denotes	animals
T8212	39688-39689	.	denotes	.
T8213	39689-39906	sentence	denotes	Gdf5-Cre/Bmpr1afloxP mutant animals showed a highly significantly reduced ability to grasp and remain suspended on a slender rod (mean suspension time: controls 38 ± 6 s, n = 39; mutants 6 ± 3 s, n = 11; p < 0.0001).
T8214	39690-39694	NN	denotes	Gdf5
T8215	39695-39698	NN	denotes	Cre
T8216	39694-39695	HYPH	denotes	-
T8217	39699-39710	NN	denotes	Bmpr1afloxP
T8218	39698-39699	HYPH	denotes	/
T8219	39711-39717	JJ	denotes	mutant
T8220	39718-39725	NNS	denotes	animals
T8221	39726-39732	VBD	denotes	showed
T8222	39733-39734	DT	denotes	a
T8223	39764-39771	NN	denotes	ability
T8224	39735-39741	RB	denotes	highly
T8225	39742-39755	RB	denotes	significantly
T8226	39756-39763	VBN	denotes	reduced
T8227	39772-39774	TO	denotes	to
T8228	39775-39780	VB	denotes	grasp
T8229	39781-39784	CC	denotes	and
T8230	39785-39791	VB	denotes	remain
T8231	39792-39801	VBN	denotes	suspended
T8232	39802-39804	IN	denotes	on
T8233	39805-39806	DT	denotes	a
T8234	39815-39818	NN	denotes	rod
T8235	39807-39814	JJ	denotes	slender
T8236	39819-39820	-LRB-	denotes	(
T8237	39836-39840	NN	denotes	time
T8238	39820-39824	JJ	denotes	mean
T8239	39825-39835	NN	denotes	suspension
T8240	39840-39842	:	denotes	:
T8241	39842-39850	NNS	denotes	controls
T8242	39858-39859	NNS	denotes	s
T8243	39851-39853	CD	denotes	38
T8244	39856-39857	CD	denotes	6
T8245	39854-39855	SYM	denotes	±
T8246	39883-39884	NNS	denotes	s
T8247	39859-39861	,	denotes	,
T8248	39861-39862	NN	denotes	n
T8249	39865-39867	CD	denotes	39
T8250	39863-39864	SYM	denotes	=
T8251	39867-39868	:	denotes	;
T8252	39869-39876	NNS	denotes	mutants
T8253	39877-39878	CD	denotes	6
T8254	39881-39882	CD	denotes	3
T8255	39879-39880	SYM	denotes	±
T8256	39884-39886	,	denotes	,
T8257	39886-39887	NN	denotes	n
T8258	39890-39892	CD	denotes	11
T8259	39888-39889	SYM	denotes	=
T8260	39892-39893	:	denotes	;
T8261	39894-39895	NN	denotes	p
T8262	39898-39904	CD	denotes	0.0001
T8263	39896-39897	SYM	denotes	<
T8264	39904-39905	-RRB-	denotes	)
T8265	39905-39906	.	denotes	.
T8266	39906-40207	sentence	denotes	Mutant mice also showed a clear decrease in the maximum range of mobility of two different joints in the digits, as assayed by passive manipulation (MT/P1 joint: controls 100 ± 0°, n = 26; mutants 82 ± 3°, n = 8; p < 0.0003; P1/P2 joint: controls 152 ± 1°, n = 23; mutants 140 ± 5°, n = 6; p < 0.05).
T8267	39907-39913	NN	denotes	Mutant
T8268	39914-39918	NNS	denotes	mice
T8269	39924-39930	VBD	denotes	showed
T8270	39919-39923	RB	denotes	also
T8271	39931-39932	DT	denotes	a
T8272	39939-39947	NN	denotes	decrease
T8273	39933-39938	JJ	denotes	clear
T8274	39948-39950	IN	denotes	in
T8275	39951-39954	DT	denotes	the
T8276	39963-39968	NN	denotes	range
T8277	39955-39962	JJ	denotes	maximum
T8278	39969-39971	IN	denotes	of
T8279	39972-39980	NN	denotes	mobility
T8280	39981-39983	IN	denotes	of
T8281	39984-39987	CD	denotes	two
T8282	39998-40004	NNS	denotes	joints
T8283	39988-39997	JJ	denotes	different
T8284	40005-40007	IN	denotes	in
T8285	40008-40011	DT	denotes	the
T8286	40012-40018	NNS	denotes	digits
T8287	40018-40020	,	denotes	,
T8288	40020-40022	IN	denotes	as
T8289	40023-40030	VBN	denotes	assayed
T8290	40031-40033	IN	denotes	by
T8291	40034-40041	JJ	denotes	passive
T8292	40042-40054	NN	denotes	manipulation
T8293	40055-40056	-LRB-	denotes	(
T8294	40201-40205	CD	denotes	0.05
T8295	40056-40058	NN	denotes	MT
T8296	40059-40061	NN	denotes	P1
T8297	40058-40059	HYPH	denotes	/
T8298	40062-40067	NN	denotes	joint
T8299	40124-40130	CD	denotes	0.0003
T8300	40067-40069	:	denotes	:
T8301	40069-40077	VBZ	denotes	controls
T8302	40092-40094	CD	denotes	26
T8303	40078-40081	CD	denotes	100
T8304	40084-40085	CD	denotes	0
T8305	40082-40083	SYM	denotes	±
T8306	40085-40086	NNS	denotes	°
T8307	40086-40088	,	denotes	,
T8308	40088-40089	NN	denotes	n
T8309	40090-40091	SYM	denotes	=
T8310	40094-40095	:	denotes	;
T8311	40096-40103	NNS	denotes	mutants
T8312	40117-40118	CD	denotes	8
T8313	40104-40106	CD	denotes	82
T8314	40109-40110	CD	denotes	3
T8315	40107-40108	SYM	denotes	±
T8316	40110-40111	NNS	denotes	°
T8317	40111-40113	,	denotes	,
T8318	40113-40114	NN	denotes	n
T8319	40115-40116	SYM	denotes	=
T8320	40118-40119	:	denotes	;
T8321	40120-40121	NN	denotes	p
T8322	40122-40123	SYM	denotes	<
T8323	40130-40131	:	denotes	;
T8324	40132-40134	NN	denotes	P1
T8325	40135-40137	NN	denotes	P2
T8326	40134-40135	HYPH	denotes	/
T8327	40138-40143	NN	denotes	joint
T8328	40143-40145	:	denotes	:
T8329	40145-40153	NNS	denotes	controls
T8330	40168-40170	CD	denotes	23
T8331	40154-40157	CD	denotes	152
T8332	40160-40161	CD	denotes	1
T8333	40158-40159	SYM	denotes	±
T8334	40161-40162	NN	denotes	°
T8335	40162-40164	,	denotes	,
T8336	40164-40165	NN	denotes	n
T8337	40166-40167	SYM	denotes	=
T8338	40170-40171	:	denotes	;
T8339	40172-40179	NNS	denotes	mutants
T8340	40194-40195	CD	denotes	6
T8341	40180-40183	CD	denotes	140
T8342	40186-40187	CD	denotes	5
T8343	40184-40185	SYM	denotes	±
T8344	40187-40188	NNS	denotes	°
T8345	40188-40190	,	denotes	,
T8346	40190-40191	NN	denotes	n
T8347	40192-40193	SYM	denotes	=
T8348	40195-40196	:	denotes	;
T8349	40197-40198	NN	denotes	p
T8350	40199-40200	SYM	denotes	<
T8351	40205-40206	-RRB-	denotes	)
T8352	40206-40207	.	denotes	.
T8353	40207-40392	sentence	denotes	The structural, histological, marker gene expression, and functional changes in mutant mice demonstrate that BMPR1A is required for normal postnatal maintenance of articular cartilage.
T8354	40208-40211	DT	denotes	The
T8355	40277-40284	NNS	denotes	changes
T8356	40212-40222	JJ	denotes	structural
T8357	40222-40224	,	denotes	,
T8358	40224-40236	JJ	denotes	histological
T8359	40236-40238	,	denotes	,
T8360	40238-40244	NN	denotes	marker
T8361	40245-40249	NN	denotes	gene
T8362	40250-40260	NN	denotes	expression
T8363	40260-40262	,	denotes	,
T8364	40262-40265	CC	denotes	and
T8365	40266-40276	JJ	denotes	functional
T8366	40300-40311	VBP	denotes	demonstrate
T8367	40285-40287	IN	denotes	in
T8368	40288-40294	NN	denotes	mutant
T8369	40295-40299	NNS	denotes	mice
T8370	40312-40316	IN	denotes	that
T8371	40327-40335	VBN	denotes	required
T8372	40317-40323	NN	denotes	BMPR1A
T8373	40324-40326	VBZ	denotes	is
T8374	40336-40339	IN	denotes	for
T8375	40340-40346	JJ	denotes	normal
T8376	40357-40368	NN	denotes	maintenance
T8377	40347-40356	JJ	denotes	postnatal
T8378	40369-40371	IN	denotes	of
T8379	40372-40381	JJ	denotes	articular
T8380	40382-40391	NN	denotes	cartilage
T8381	40391-40392	.	denotes	.
T9223	40405-40413	JJ	denotes	Previous
T9224	40414-40421	NNS	denotes	studies
T9225	40422-40429	VBP	denotes	suggest
T9226	40430-40434	IN	denotes	that
T9227	40452-40460	VBN	denotes	involved
T9228	40435-40438	NN	denotes	BMP
T9229	40439-40448	NN	denotes	signaling
T9230	40449-40451	VBZ	denotes	is
T9231	40461-40463	IN	denotes	in
T9232	40464-40465	DT	denotes	a
T9233	40472-40478	NN	denotes	number
T9234	40466-40471	JJ	denotes	large
T9235	40479-40481	IN	denotes	of
T9236	40482-40495	JJ	denotes	developmental
T9237	40496-40502	NNS	denotes	events
T9238	40502-40503	.	denotes	.
T9239	40503-40641	sentence	denotes	Many of these events occur early in embryogenesis, and complete inactivation of BMP receptors causes death by E9.5 (Mishina et al. 1995).
T9240	40504-40508	JJ	denotes	Many
T9241	40525-40530	VBP	denotes	occur
T9242	40509-40511	IN	denotes	of
T9243	40512-40517	DT	denotes	these
T9244	40518-40524	NNS	denotes	events
T9245	40531-40536	RB	denotes	early
T9246	40537-40539	IN	denotes	in
T9247	40540-40553	NN	denotes	embryogenesis
T9248	40553-40555	,	denotes	,
T9249	40555-40558	CC	denotes	and
T9250	40559-40567	JJ	denotes	complete
T9251	40568-40580	NN	denotes	inactivation
T9252	40598-40604	VBZ	denotes	causes
T9253	40581-40583	IN	denotes	of
T9254	40584-40587	NN	denotes	BMP
T9255	40588-40597	NNS	denotes	receptors
T9256	40605-40610	NN	denotes	death
T9257	40611-40613	IN	denotes	by
T9258	40614-40618	NN	denotes	E9.5
T9259	40619-40620	-LRB-	denotes	(
T9260	40620-40627	NNP	denotes	Mishina
T9261	40628-40630	FW	denotes	et
T9262	40631-40634	FW	denotes	al.
T9263	40635-40639	CD	denotes	1995
T9264	40639-40640	-RRB-	denotes	)
T9265	40640-40641	.	denotes	.
T9266	40641-40840	sentence	denotes	The Gdf5-Cre recombination system bypasses the early embryonic lethality of Bmpr1a mutations, and provides important new information about the role of this receptor in limb and skeletal development.
T9267	40642-40645	DT	denotes	The
T9268	40669-40675	NN	denotes	system
T9269	40646-40650	NN	denotes	Gdf5
T9270	40651-40654	NN	denotes	Cre
T9271	40650-40651	HYPH	denotes	-
T9272	40655-40668	NN	denotes	recombination
T9273	40676-40684	VBZ	denotes	bypasses
T9274	40685-40688	DT	denotes	the
T9275	40705-40714	NN	denotes	lethality
T9276	40689-40694	JJ	denotes	early
T9277	40695-40704	JJ	denotes	embryonic
T9278	40715-40717	IN	denotes	of
T9279	40718-40724	NN	denotes	Bmpr1a
T9280	40725-40734	NNS	denotes	mutations
T9281	40734-40736	,	denotes	,
T9282	40736-40739	CC	denotes	and
T9283	40740-40748	VBZ	denotes	provides
T9284	40749-40758	JJ	denotes	important
T9285	40763-40774	NN	denotes	information
T9286	40759-40762	JJ	denotes	new
T9287	40775-40780	IN	denotes	about
T9288	40781-40784	DT	denotes	the
T9289	40785-40789	NN	denotes	role
T9290	40790-40792	IN	denotes	of
T9291	40793-40797	DT	denotes	this
T9292	40798-40806	NN	denotes	receptor
T9293	40807-40809	IN	denotes	in
T9294	40810-40814	NN	denotes	limb
T9295	40828-40839	NN	denotes	development
T9296	40815-40818	CC	denotes	and
T9297	40819-40827	JJ	denotes	skeletal
T9298	40839-40840	.	denotes	.
T9299	40840-41104	sentence	denotes	The three major limb phenotypes revealed by eliminating Bmpr1a with Gdf5-driven Cre include webbing between digits, lack of joint formation at specific locations in the ankle, and failure to maintain articular cartilage after birth, resulting in severe arthritis.
T9300	40841-40844	DT	denotes	The
T9301	40862-40872	NNS	denotes	phenotypes
T9302	40845-40850	CD	denotes	three
T9303	40851-40856	JJ	denotes	major
T9304	40857-40861	NN	denotes	limb
T9305	40925-40932	VBP	denotes	include
T9306	40873-40881	VBN	denotes	revealed
T9307	40882-40884	IN	denotes	by
T9308	40885-40896	VBG	denotes	eliminating
T9309	40897-40903	NN	denotes	Bmpr1a
T9310	40904-40908	IN	denotes	with
T9311	40909-40913	NN	denotes	Gdf5
T9312	40914-40920	VBN	denotes	driven
T9313	40913-40914	HYPH	denotes	-
T9314	40921-40924	NN	denotes	Cre
T9315	40933-40940	NN	denotes	webbing
T9316	40941-40948	IN	denotes	between
T9317	40949-40955	NNS	denotes	digits
T9318	40955-40957	,	denotes	,
T9319	40957-40961	NN	denotes	lack
T9320	40962-40964	IN	denotes	of
T9321	40965-40970	NN	denotes	joint
T9322	40971-40980	NN	denotes	formation
T9323	40981-40983	IN	denotes	at
T9324	40984-40992	JJ	denotes	specific
T9325	40993-41002	NNS	denotes	locations
T9326	41003-41005	IN	denotes	in
T9327	41006-41009	DT	denotes	the
T9328	41010-41015	NN	denotes	ankle
T9329	41015-41017	,	denotes	,
T9330	41017-41020	CC	denotes	and
T9331	41021-41028	NN	denotes	failure
T9332	41029-41031	TO	denotes	to
T9333	41032-41040	VB	denotes	maintain
T9334	41041-41050	JJ	denotes	articular
T9335	41051-41060	NN	denotes	cartilage
T9336	41061-41066	IN	denotes	after
T9337	41067-41072	NN	denotes	birth
T9338	41072-41074	,	denotes	,
T9339	41074-41083	VBG	denotes	resulting
T9340	41084-41086	IN	denotes	in
T9341	41087-41093	JJ	denotes	severe
T9342	41094-41103	NN	denotes	arthritis
T9343	41103-41104	.	denotes	.
T9344	41104-41426	sentence	denotes	Previous studies have shown that manipulation of BMP signaling alters interdigital apoptosis during development of the limb, but no experiment has identified a specific member of the BMP signaling pathway that is required for this process (Yokouchi et al. 1996; Zou and Niswander 1996; Zou et al. 1997; Guha et al. 2002).
T9345	41105-41113	JJ	denotes	Previous
T9346	41114-41121	NNS	denotes	studies
T9347	41127-41132	VBN	denotes	shown
T9348	41122-41126	VBP	denotes	have
T9349	41133-41137	IN	denotes	that
T9350	41168-41174	VBZ	denotes	alters
T9351	41138-41150	NN	denotes	manipulation
T9352	41151-41153	IN	denotes	of
T9353	41154-41157	NN	denotes	BMP
T9354	41158-41167	NN	denotes	signaling
T9355	41175-41187	JJ	denotes	interdigital
T9356	41188-41197	NN	denotes	apoptosis
T9357	41198-41204	IN	denotes	during
T9358	41205-41216	NN	denotes	development
T9359	41217-41219	IN	denotes	of
T9360	41220-41223	DT	denotes	the
T9361	41224-41228	NN	denotes	limb
T9362	41228-41230	,	denotes	,
T9363	41230-41233	CC	denotes	but
T9364	41234-41236	DT	denotes	no
T9365	41237-41247	NN	denotes	experiment
T9366	41252-41262	VBN	denotes	identified
T9367	41248-41251	VBZ	denotes	has
T9368	41263-41264	DT	denotes	a
T9369	41274-41280	NN	denotes	member
T9370	41265-41273	JJ	denotes	specific
T9371	41281-41283	IN	denotes	of
T9372	41284-41287	DT	denotes	the
T9373	41302-41309	NN	denotes	pathway
T9374	41288-41291	NN	denotes	BMP
T9375	41292-41301	NN	denotes	signaling
T9376	41310-41314	WDT	denotes	that
T9377	41318-41326	VBN	denotes	required
T9378	41315-41317	VBZ	denotes	is
T9379	41327-41330	IN	denotes	for
T9380	41331-41335	DT	denotes	this
T9381	41336-41343	NN	denotes	process
T9382	41344-41345	-LRB-	denotes	(
T9383	41345-41353	NNP	denotes	Yokouchi
T9384	41354-41356	FW	denotes	et
T9385	41357-41360	FW	denotes	al.
T9386	41361-41365	CD	denotes	1996
T9387	41365-41366	:	denotes	;
T9388	41367-41370	NNP	denotes	Zou
T9389	41371-41374	CC	denotes	and
T9390	41375-41384	NNP	denotes	Niswander
T9391	41385-41389	CD	denotes	1996
T9392	41389-41390	:	denotes	;
T9393	41391-41394	NNP	denotes	Zou
T9394	41395-41397	FW	denotes	et
T9395	41398-41401	FW	denotes	al.
T9396	41402-41406	CD	denotes	1997
T9397	41406-41407	:	denotes	;
T9398	41408-41412	NNP	denotes	Guha
T9399	41413-41415	FW	denotes	et
T9400	41416-41419	FW	denotes	al.
T9401	41420-41424	CD	denotes	2002
T9402	41424-41425	-RRB-	denotes	)
T9403	41425-41426	.	denotes	.
T9404	41426-41598	sentence	denotes	Our new loss-of-function data confirm that BMP signaling is required for interdigital apoptosis and suggests that Bmpr1a is a critical component for mediating this signal.
T9405	41427-41430	PRP$	denotes	Our
T9406	41452-41456	NNS	denotes	data
T9407	41431-41434	JJ	denotes	new
T9408	41435-41439	NN	denotes	loss
T9409	41439-41440	HYPH	denotes	-
T9410	41440-41442	IN	denotes	of
T9411	41442-41443	HYPH	denotes	-
T9412	41443-41451	NN	denotes	function
T9413	41457-41464	VBP	denotes	confirm
T9414	41465-41469	IN	denotes	that
T9415	41487-41495	VBN	denotes	required
T9416	41470-41473	NN	denotes	BMP
T9417	41474-41483	NN	denotes	signaling
T9418	41484-41486	VBZ	denotes	is
T9419	41496-41499	IN	denotes	for
T9420	41500-41512	JJ	denotes	interdigital
T9421	41513-41522	NN	denotes	apoptosis
T9422	41523-41526	CC	denotes	and
T9423	41527-41535	VBZ	denotes	suggests
T9424	41536-41540	IN	denotes	that
T9425	41548-41550	VBZ	denotes	is
T9426	41541-41547	NN	denotes	Bmpr1a
T9427	41551-41552	DT	denotes	a
T9428	41562-41571	NN	denotes	component
T9429	41553-41561	JJ	denotes	critical
T9430	41572-41575	IN	denotes	for
T9431	41576-41585	VBG	denotes	mediating
T9432	41586-41590	DT	denotes	this
T9433	41591-41597	NN	denotes	signal
T9434	41597-41598	.	denotes	.
T9435	41598-41777	sentence	denotes	At some sites, loss of Bmpr1a function leads to a defect in the early stages of joint formation, resulting in a complete failure to form a joint and fusion of bones in the ankle.
T9436	41599-41601	IN	denotes	At
T9437	41638-41643	VBZ	denotes	leads
T9438	41602-41606	DT	denotes	some
T9439	41607-41612	NNS	denotes	sites
T9440	41612-41614	,	denotes	,
T9441	41614-41618	NN	denotes	loss
T9442	41619-41621	IN	denotes	of
T9443	41622-41628	NN	denotes	Bmpr1a
T9444	41629-41637	NN	denotes	function
T9445	41644-41646	IN	denotes	to
T9446	41647-41648	DT	denotes	a
T9447	41649-41655	NN	denotes	defect
T9448	41656-41658	IN	denotes	in
T9449	41659-41662	DT	denotes	the
T9450	41669-41675	NNS	denotes	stages
T9451	41663-41668	JJ	denotes	early
T9452	41676-41678	IN	denotes	of
T9453	41679-41684	NN	denotes	joint
T9454	41685-41694	NN	denotes	formation
T9455	41694-41696	,	denotes	,
T9456	41696-41705	VBG	denotes	resulting
T9457	41706-41708	IN	denotes	in
T9458	41709-41710	DT	denotes	a
T9459	41720-41727	NN	denotes	failure
T9460	41711-41719	JJ	denotes	complete
T9461	41728-41730	TO	denotes	to
T9462	41731-41735	VB	denotes	form
T9463	41736-41737	DT	denotes	a
T9464	41738-41743	NN	denotes	joint
T9465	41744-41747	CC	denotes	and
T9466	41748-41754	NN	denotes	fusion
T9467	41755-41757	IN	denotes	of
T9468	41758-41763	NNS	denotes	bones
T9469	41764-41766	IN	denotes	in
T9470	41767-41770	DT	denotes	the
T9471	41771-41776	NN	denotes	ankle
T9472	41776-41777	.	denotes	.
T9473	41777-42071	sentence	denotes	Mutations in two different ligands in the BMP family, Gdf5 and Gdf6, the Bmpr1b receptor, and in the human Noggin locus (Storm and Kingsley 1996; Gong et al. 1999; Baur et al. 2000; Yi et al. 2000; Settle et al. 2003) also produce defects in joint formation at specific locations in the limbs.
T9474	41778-41787	NNS	denotes	Mutations
T9475	42001-42008	VBP	denotes	produce
T9476	41788-41790	IN	denotes	in
T9477	41791-41794	CD	denotes	two
T9478	41805-41812	NNS	denotes	ligands
T9479	41795-41804	JJ	denotes	different
T9480	41813-41815	IN	denotes	in
T9481	41816-41819	DT	denotes	the
T9482	41824-41830	NN	denotes	family
T9483	41820-41823	NN	denotes	BMP
T9484	41830-41832	,	denotes	,
T9485	41832-41836	NN	denotes	Gdf5
T9486	41837-41840	CC	denotes	and
T9487	41841-41845	NN	denotes	Gdf6
T9488	41845-41847	,	denotes	,
T9489	41847-41850	DT	denotes	the
T9490	41858-41866	NN	denotes	receptor
T9491	41851-41857	NN	denotes	Bmpr1b
T9492	41866-41868	,	denotes	,
T9493	41868-41871	CC	denotes	and
T9494	41872-41874	IN	denotes	in
T9495	41875-41878	DT	denotes	the
T9496	41892-41897	NN	denotes	locus
T9497	41879-41884	JJ	denotes	human
T9498	41885-41891	NN	denotes	Noggin
T9499	41898-41899	-LRB-	denotes	(
T9500	41899-41904	NNP	denotes	Storm
T9501	41905-41908	CC	denotes	and
T9502	41909-41917	NNP	denotes	Kingsley
T9503	41918-41922	CD	denotes	1996
T9504	41922-41923	:	denotes	;
T9505	41924-41928	NNP	denotes	Gong
T9506	41929-41931	FW	denotes	et
T9507	41932-41935	FW	denotes	al.
T9508	41936-41940	CD	denotes	1999
T9509	41940-41941	:	denotes	;
T9510	41942-41946	NNP	denotes	Baur
T9511	41947-41949	FW	denotes	et
T9512	41950-41953	FW	denotes	al.
T9513	41954-41958	CD	denotes	2000
T9514	41958-41959	:	denotes	;
T9515	41960-41962	NNP	denotes	Yi
T9516	41963-41965	FW	denotes	et
T9517	41966-41969	FW	denotes	al.
T9518	41970-41974	CD	denotes	2000
T9519	41974-41975	:	denotes	;
T9520	41976-41982	NNP	denotes	Settle
T9521	41983-41985	FW	denotes	et
T9522	41986-41989	FW	denotes	al.
T9523	41990-41994	CD	denotes	2003
T9524	41994-41995	-RRB-	denotes	)
T9525	41996-42000	RB	denotes	also
T9526	42009-42016	NNS	denotes	defects
T9527	42017-42019	IN	denotes	in
T9528	42020-42025	NN	denotes	joint
T9529	42026-42035	NN	denotes	formation
T9530	42036-42038	IN	denotes	at
T9531	42039-42047	JJ	denotes	specific
T9532	42048-42057	NNS	denotes	locations
T9533	42058-42060	IN	denotes	in
T9534	42061-42064	DT	denotes	the
T9535	42065-42070	NNS	denotes	limbs
T9536	42070-42071	.	denotes	.
T9537	42071-42265	sentence	denotes	The joint defects associated with multiple components of the BMP pathway provide strong evidence that BMP signaling is required for early stages of joint formation at some anatomical locations.
T9538	42072-42075	DT	denotes	The
T9539	42082-42089	NNS	denotes	defects
T9540	42076-42081	NN	denotes	joint
T9541	42145-42152	VBP	denotes	provide
T9542	42090-42100	VBN	denotes	associated
T9543	42101-42105	IN	denotes	with
T9544	42106-42114	JJ	denotes	multiple
T9545	42115-42125	NNS	denotes	components
T9546	42126-42128	IN	denotes	of
T9547	42129-42132	DT	denotes	the
T9548	42137-42144	NN	denotes	pathway
T9549	42133-42136	NN	denotes	BMP
T9550	42153-42159	JJ	denotes	strong
T9551	42160-42168	NN	denotes	evidence
T9552	42169-42173	IN	denotes	that
T9553	42191-42199	VBN	denotes	required
T9554	42174-42177	NN	denotes	BMP
T9555	42178-42187	NN	denotes	signaling
T9556	42188-42190	VBZ	denotes	is
T9557	42200-42203	IN	denotes	for
T9558	42204-42209	JJ	denotes	early
T9559	42210-42216	NNS	denotes	stages
T9560	42217-42219	IN	denotes	of
T9561	42220-42225	NN	denotes	joint
T9562	42226-42235	NN	denotes	formation
T9563	42236-42238	IN	denotes	at
T9564	42239-42243	DT	denotes	some
T9565	42255-42264	NNS	denotes	locations
T9566	42244-42254	JJ	denotes	anatomical
T9567	42264-42265	.	denotes	.
T9568	42265-42352	sentence	denotes	Most joints still form normally when Bmpr1a is knocked out in Gdf5 expression domains.
T9569	42266-42270	JJS	denotes	Most
T9570	42271-42277	NNS	denotes	joints
T9571	42284-42288	VBP	denotes	form
T9572	42278-42283	RB	denotes	still
T9573	42289-42297	RB	denotes	normally
T9574	42298-42302	WRB	denotes	when
T9575	42313-42320	VBN	denotes	knocked
T9576	42303-42309	NN	denotes	Bmpr1a
T9577	42310-42312	VBZ	denotes	is
T9578	42321-42324	RP	denotes	out
T9579	42325-42327	IN	denotes	in
T9580	42328-42332	NN	denotes	Gdf5
T9581	42344-42351	NNS	denotes	domains
T9582	42333-42343	NN	denotes	expression
T9583	42351-42352	.	denotes	.
T9584	42352-42672	sentence	denotes	The lack of joint fusions outside the ankle region could be due to differences in requirement for BMP signaling in different joints, to compensating expression of other BMP receptors outside the ankles, or to differences in the detailed timing of Gdf5-Cre stimulated gene inactivation in ankles and other joint regions.
T9585	42353-42356	DT	denotes	The
T9586	42357-42361	NN	denotes	lack
T9587	42410-42412	VB	denotes	be
T9588	42362-42364	IN	denotes	of
T9589	42365-42370	NN	denotes	joint
T9590	42371-42378	NNS	denotes	fusions
T9591	42379-42386	IN	denotes	outside
T9592	42387-42390	DT	denotes	the
T9593	42397-42403	NN	denotes	region
T9594	42391-42396	NN	denotes	ankle
T9595	42404-42409	MD	denotes	could
T9596	42413-42416	IN	denotes	due
T9597	42417-42419	IN	denotes	to
T9598	42420-42431	NNS	denotes	differences
T9599	42432-42434	IN	denotes	in
T9600	42435-42446	NN	denotes	requirement
T9601	42447-42450	IN	denotes	for
T9602	42451-42454	NN	denotes	BMP
T9603	42455-42464	NN	denotes	signaling
T9604	42465-42467	IN	denotes	in
T9605	42468-42477	JJ	denotes	different
T9606	42478-42484	NNS	denotes	joints
T9607	42484-42486	,	denotes	,
T9608	42486-42488	IN	denotes	to
T9609	42489-42501	VBG	denotes	compensating
T9610	42502-42512	NN	denotes	expression
T9611	42513-42515	IN	denotes	of
T9612	42516-42521	JJ	denotes	other
T9613	42526-42535	NNS	denotes	receptors
T9614	42522-42525	NN	denotes	BMP
T9615	42536-42543	IN	denotes	outside
T9616	42544-42547	DT	denotes	the
T9617	42548-42554	NNS	denotes	ankles
T9618	42554-42556	,	denotes	,
T9619	42556-42558	CC	denotes	or
T9620	42559-42561	IN	denotes	to
T9621	42562-42573	NNS	denotes	differences
T9622	42574-42576	IN	denotes	in
T9623	42577-42580	DT	denotes	the
T9624	42590-42596	NN	denotes	timing
T9625	42581-42589	VBN	denotes	detailed
T9626	42597-42599	IN	denotes	of
T9627	42600-42604	NN	denotes	Gdf5
T9628	42605-42608	NN	denotes	Cre
T9629	42604-42605	HYPH	denotes	-
T9630	42609-42619	VBN	denotes	stimulated
T9631	42625-42637	NN	denotes	inactivation
T9632	42620-42624	NN	denotes	gene
T9633	42638-42640	IN	denotes	in
T9634	42641-42647	NNS	denotes	ankles
T9635	42648-42651	CC	denotes	and
T9636	42652-42657	JJ	denotes	other
T9637	42664-42671	NNS	denotes	regions
T9638	42658-42663	NN	denotes	joint
T9639	42671-42672	.	denotes	.
T9640	42672-42966	sentence	denotes	Comparison of the expression of the HPLAP marker (driven directly by Gdf5 control elements) and the R26R LACZ marker (expressed following Gdf5-Cre recombination) suggests that recombination-stimulated changes in gene expression may be delayed for a 0.5–1 d in the digit region (see Figure 1C).
T9641	42673-42683	NN	denotes	Comparison
T9642	42835-42843	VBZ	denotes	suggests
T9643	42684-42686	IN	denotes	of
T9644	42687-42690	DT	denotes	the
T9645	42691-42701	NN	denotes	expression
T9646	42702-42704	IN	denotes	of
T9647	42705-42708	DT	denotes	the
T9648	42715-42721	NN	denotes	marker
T9649	42709-42714	NN	denotes	HPLAP
T9650	42722-42723	-LRB-	denotes	(
T9651	42723-42729	VBN	denotes	driven
T9652	42730-42738	RB	denotes	directly
T9653	42739-42741	IN	denotes	by
T9654	42742-42746	NN	denotes	Gdf5
T9655	42755-42763	NNS	denotes	elements
T9656	42747-42754	NN	denotes	control
T9657	42763-42764	-RRB-	denotes	)
T9658	42765-42768	CC	denotes	and
T9659	42769-42772	DT	denotes	the
T9660	42783-42789	NN	denotes	marker
T9661	42773-42777	NN	denotes	R26R
T9662	42778-42782	NN	denotes	LACZ
T9663	42790-42791	-LRB-	denotes	(
T9664	42791-42800	VBN	denotes	expressed
T9665	42801-42810	VBG	denotes	following
T9666	42811-42815	NN	denotes	Gdf5
T9667	42816-42819	NN	denotes	Cre
T9668	42815-42816	HYPH	denotes	-
T9669	42820-42833	NN	denotes	recombination
T9670	42833-42834	-RRB-	denotes	)
T9674	42863-42873	VBN	denotes	stimulated
T9675	42862-42863	HYPH	denotes	-
T9676	42874-42881	NNS	denotes	changes
T9677	42882-42884	IN	denotes	in
T9678	42885-42889	NN	denotes	gene
T9679	42890-42900	NN	denotes	expression
T9680	42901-42904	MD	denotes	may
T9681	42905-42907	VB	denotes	be
T9682	42916-42919	IN	denotes	for
T9683	42920-42921	DT	denotes	a
T9684	42928-42929	NN	denotes	d
T9685	42922-42925	CD	denotes	0.5
T9686	42926-42927	CD	denotes	1
T9687	42925-42926	SYM	denotes	–
T9688	42930-42932	IN	denotes	in
T9689	42933-42936	DT	denotes	the
T9690	42943-42949	NN	denotes	region
T9691	42937-42942	NN	denotes	digit
T9692	42950-42951	-LRB-	denotes	(
T9693	42951-42954	VB	denotes	see
T9694	42955-42961	NN	denotes	Figure
T9695	42962-42964	CD	denotes	1C
T9696	42964-42965	-RRB-	denotes	)
T9697	42965-42966	.	denotes	.
T9698	42966-43183	sentence	denotes	In addition, levels of Bmpr1a mRNA and protein may persist for some time following Gdf5-Cre stimulated recombination, making it possible to bypass an early requirement for Bmpr1a in joint formation at some locations.
T9699	42967-42969	IN	denotes	In
T9700	43018-43025	VB	denotes	persist
T9701	42970-42978	NN	denotes	addition
T9702	42978-42980	,	denotes	,
T9703	42980-42986	NNS	denotes	levels
T9704	42987-42989	IN	denotes	of
T9705	42990-42996	NN	denotes	Bmpr1a
T9706	42997-43001	NN	denotes	mRNA
T9707	43002-43005	CC	denotes	and
T9708	43006-43013	NN	denotes	protein
T9709	43014-43017	MD	denotes	may
T9710	43026-43029	IN	denotes	for
T9711	43030-43034	DT	denotes	some
T9712	43035-43039	NN	denotes	time
T9713	43040-43049	VBG	denotes	following
T9714	43050-43054	NN	denotes	Gdf5
T9715	43055-43058	NN	denotes	Cre
T9716	43054-43055	HYPH	denotes	-
T9717	43059-43069	VBN	denotes	stimulated
T9718	43070-43083	NN	denotes	recombination
T9719	43083-43085	,	denotes	,
T9720	43085-43091	VBG	denotes	making
T9721	43092-43094	PRP	denotes	it
T9722	43095-43103	JJ	denotes	possible
T9723	43104-43106	TO	denotes	to
T9724	43107-43113	VB	denotes	bypass
T9725	43114-43116	DT	denotes	an
T9726	43123-43134	NN	denotes	requirement
T9727	43117-43122	JJ	denotes	early
T9728	43135-43138	IN	denotes	for
T9729	43139-43145	NN	denotes	Bmpr1a
T9730	43146-43148	IN	denotes	in
T9731	43149-43154	NN	denotes	joint
T9732	43155-43164	NN	denotes	formation
T9733	43165-43167	IN	denotes	at
T9734	43168-43172	DT	denotes	some
T9735	43173-43182	NNS	denotes	locations
T9736	43182-43183	.	denotes	.
T9737	43183-43333	sentence	denotes	Following the decay of Bmpr1a mRNA and protein, the Gdf5-Cre strategy should result in permanent inactivation of Bmpr1a function in recombined cells.
T9738	43184-43193	VBG	denotes	Following
T9739	43261-43267	VB	denotes	result
T9740	43194-43197	DT	denotes	the
T9741	43198-43203	NN	denotes	decay
T9742	43204-43206	IN	denotes	of
T9743	43207-43213	NN	denotes	Bmpr1a
T9744	43214-43218	NN	denotes	mRNA
T9745	43219-43222	CC	denotes	and
T9746	43223-43230	NN	denotes	protein
T9747	43230-43232	,	denotes	,
T9748	43232-43235	DT	denotes	the
T9749	43245-43253	NN	denotes	strategy
T9750	43236-43240	NN	denotes	Gdf5
T9751	43241-43244	NN	denotes	Cre
T9752	43240-43241	HYPH	denotes	-
T9753	43254-43260	MD	denotes	should
T9754	43268-43270	IN	denotes	in
T9755	43271-43280	JJ	denotes	permanent
T9756	43281-43293	NN	denotes	inactivation
T9757	43294-43296	IN	denotes	of
T9758	43297-43303	NN	denotes	Bmpr1a
T9759	43304-43312	NN	denotes	function
T9760	43313-43315	IN	denotes	in
T9761	43316-43326	VBN	denotes	recombined
T9762	43327-43332	NNS	denotes	cells
T9763	43332-43333	.	denotes	.
T9764	43333-43454	sentence	denotes	This system thus provides one of the first strong genetic tests of Bmpr1a function at later stages of joint development.
T9765	43334-43338	DT	denotes	This
T9766	43339-43345	NN	denotes	system
T9767	43351-43359	VBZ	denotes	provides
T9768	43346-43350	RB	denotes	thus
T9769	43360-43363	CD	denotes	one
T9770	43364-43366	IN	denotes	of
T9771	43367-43370	DT	denotes	the
T9772	43392-43397	NNS	denotes	tests
T9773	43371-43376	JJ	denotes	first
T9774	43377-43383	JJ	denotes	strong
T9775	43384-43391	JJ	denotes	genetic
T9776	43398-43400	IN	denotes	of
T9777	43401-43407	NN	denotes	Bmpr1a
T9778	43408-43416	NN	denotes	function
T9779	43417-43419	IN	denotes	at
T9780	43420-43425	JJ	denotes	later
T9781	43426-43432	NNS	denotes	stages
T9782	43433-43435	IN	denotes	of
T9783	43436-43441	NN	denotes	joint
T9784	43442-43453	NN	denotes	development
T9785	43453-43454	.	denotes	.
T9786	43454-43690	sentence	denotes	Despite the normal appearance of articular regions and gene expression immediately after birth, Bmpr1a-deficient animals are unable to maintain the normal differentiated state of articular cartilage as they continue to develop and age.
T9787	43455-43462	IN	denotes	Despite
T9788	43576-43579	VBP	denotes	are
T9789	43463-43466	DT	denotes	the
T9790	43474-43484	NN	denotes	appearance
T9791	43467-43473	JJ	denotes	normal
T9792	43485-43487	IN	denotes	of
T9793	43488-43497	JJ	denotes	articular
T9794	43498-43505	NNS	denotes	regions
T9795	43506-43509	CC	denotes	and
T9796	43510-43514	NN	denotes	gene
T9797	43515-43525	NN	denotes	expression
T9798	43526-43537	RB	denotes	immediately
T9799	43538-43543	IN	denotes	after
T9800	43544-43549	NN	denotes	birth
T9801	43549-43551	,	denotes	,
T9802	43551-43557	NN	denotes	Bmpr1a
T9803	43558-43567	JJ	denotes	deficient
T9804	43557-43558	HYPH	denotes	-
T9805	43568-43575	NNS	denotes	animals
T9806	43580-43586	JJ	denotes	unable
T9807	43587-43589	TO	denotes	to
T9808	43590-43598	VB	denotes	maintain
T9809	43599-43602	DT	denotes	the
T9810	43625-43630	NN	denotes	state
T9811	43603-43609	JJ	denotes	normal
T9812	43610-43624	VBN	denotes	differentiated
T9813	43631-43633	IN	denotes	of
T9814	43634-43643	JJ	denotes	articular
T9815	43644-43653	NN	denotes	cartilage
T9816	43654-43656	IN	denotes	as
T9817	43662-43670	VBP	denotes	continue
T9818	43657-43661	PRP	denotes	they
T9819	43671-43673	TO	denotes	to
T9820	43674-43681	VB	denotes	develop
T9821	43682-43685	CC	denotes	and
T9822	43686-43689	VB	denotes	age
T9823	43689-43690	.	denotes	.
T9824	43690-43836	sentence	denotes	These results suggest that BMP receptor signaling is essential for continued health and integrity of articular cartilage in the postnatal period.
T9825	43691-43696	DT	denotes	These
T9826	43697-43704	NNS	denotes	results
T9827	43705-43712	VBP	denotes	suggest
T9828	43713-43717	IN	denotes	that
T9829	43741-43743	VBZ	denotes	is
T9830	43718-43721	NN	denotes	BMP
T9831	43722-43730	NN	denotes	receptor
T9832	43731-43740	NN	denotes	signaling
T9833	43744-43753	JJ	denotes	essential
T9834	43754-43757	IN	denotes	for
T9835	43758-43767	VBN	denotes	continued
T9836	43768-43774	NN	denotes	health
T9837	43775-43778	CC	denotes	and
T9838	43779-43788	NN	denotes	integrity
T9839	43789-43791	IN	denotes	of
T9840	43792-43801	JJ	denotes	articular
T9841	43802-43811	NN	denotes	cartilage
T9842	43812-43814	IN	denotes	in
T9843	43815-43818	DT	denotes	the
T9844	43829-43835	NN	denotes	period
T9845	43819-43828	JJ	denotes	postnatal
T9846	43835-43836	.	denotes	.
T9847	43836-43986	sentence	denotes	Articular cartilage is a key component of synovial joints and is one of the few regions in the skeleton where cartilage is maintained into adulthood.
T9848	43837-43846	JJ	denotes	Articular
T9849	43847-43856	NN	denotes	cartilage
T9850	43857-43859	VBZ	denotes	is
T9851	43860-43861	DT	denotes	a
T9852	43866-43875	NN	denotes	component
T9853	43862-43865	JJ	denotes	key
T9854	43876-43878	IN	denotes	of
T9855	43879-43887	JJ	denotes	synovial
T9856	43888-43894	NNS	denotes	joints
T9857	43895-43898	CC	denotes	and
T9858	43899-43901	VBZ	denotes	is
T9859	43902-43905	CD	denotes	one
T9860	43906-43908	IN	denotes	of
T9861	43909-43912	DT	denotes	the
T9862	43917-43924	NNS	denotes	regions
T9863	43913-43916	JJ	denotes	few
T9864	43925-43927	IN	denotes	in
T9865	43928-43931	DT	denotes	the
T9866	43932-43940	NN	denotes	skeleton
T9867	43941-43946	WRB	denotes	where
T9868	43960-43970	VBN	denotes	maintained
T9869	43947-43956	NN	denotes	cartilage
T9870	43957-43959	VBZ	denotes	is
T9871	43971-43975	IN	denotes	into
T9872	43976-43985	NN	denotes	adulthood
T9873	43985-43986	.	denotes	.
T9874	43986-44166	sentence	denotes	Despite the importance of articular cartilage in joint health and mobility, little is known about the factors that create and maintain it in thin layers at the ends of long bones.
T9875	43987-43994	IN	denotes	Despite
T9876	44073-44078	VBN	denotes	known
T9877	43995-43998	DT	denotes	the
T9878	43999-44009	NN	denotes	importance
T9879	44010-44012	IN	denotes	of
T9880	44013-44022	JJ	denotes	articular
T9881	44023-44032	NN	denotes	cartilage
T9882	44033-44035	IN	denotes	in
T9883	44036-44041	NN	denotes	joint
T9884	44042-44048	NN	denotes	health
T9885	44049-44052	CC	denotes	and
T9886	44053-44061	NN	denotes	mobility
T9887	44061-44063	,	denotes	,
T9888	44063-44069	JJ	denotes	little
T9889	44070-44072	VBZ	denotes	is
T9890	44079-44084	IN	denotes	about
T9891	44085-44088	DT	denotes	the
T9892	44089-44096	NNS	denotes	factors
T9893	44097-44101	WDT	denotes	that
T9894	44102-44108	VBP	denotes	create
T9895	44109-44112	CC	denotes	and
T9896	44113-44121	VBP	denotes	maintain
T9897	44122-44124	PRP	denotes	it
T9898	44125-44127	IN	denotes	in
T9899	44128-44132	JJ	denotes	thin
T9900	44133-44139	NNS	denotes	layers
T9901	44140-44142	IN	denotes	at
T9902	44143-44146	DT	denotes	the
T9903	44147-44151	NNS	denotes	ends
T9904	44152-44154	IN	denotes	of
T9905	44155-44159	JJ	denotes	long
T9906	44160-44165	NNS	denotes	bones
T9907	44165-44166	.	denotes	.
T9908	44166-44463	sentence	denotes	In our experiments, articular cartilage lacking Bmpr1a retains some normal characteristics, in that it maintains a very low proliferation rate, does not express Col1a1, and continues to express SOX9, a major transcription factor regulating expression of structural components of cartilage matrix.
T9909	44167-44169	IN	denotes	In
T9910	44222-44229	VBZ	denotes	retains
T9911	44170-44173	PRP$	denotes	our
T9912	44174-44185	NNS	denotes	experiments
T9913	44185-44187	,	denotes	,
T9914	44187-44196	JJ	denotes	articular
T9915	44197-44206	NN	denotes	cartilage
T9916	44207-44214	VBG	denotes	lacking
T9917	44215-44221	NN	denotes	Bmpr1a
T9918	44230-44234	DT	denotes	some
T9919	44242-44257	NNS	denotes	characteristics
T9920	44235-44241	JJ	denotes	normal
T9921	44257-44259	,	denotes	,
T9922	44259-44261	IN	denotes	in
T9923	44270-44279	VBZ	denotes	maintains
T9924	44262-44266	IN	denotes	that
T9925	44267-44269	PRP	denotes	it
T9926	44280-44281	DT	denotes	a
T9927	44305-44309	NN	denotes	rate
T9928	44282-44286	RB	denotes	very
T9929	44287-44290	JJ	denotes	low
T9930	44291-44304	NN	denotes	proliferation
T9931	44309-44311	,	denotes	,
T9932	44311-44315	VBZ	denotes	does
T9933	44320-44327	VB	denotes	express
T9934	44316-44319	RB	denotes	not
T9935	44328-44334	NN	denotes	Col1a1
T9936	44334-44336	,	denotes	,
T9937	44336-44339	CC	denotes	and
T9938	44340-44349	VBZ	denotes	continues
T9939	44350-44352	TO	denotes	to
T9940	44353-44360	VB	denotes	express
T9941	44361-44365	NN	denotes	SOX9
T9942	44365-44367	,	denotes	,
T9943	44367-44368	DT	denotes	a
T9944	44389-44395	NN	denotes	factor
T9945	44369-44374	JJ	denotes	major
T9946	44375-44388	NN	denotes	transcription
T9947	44396-44406	VBG	denotes	regulating
T9948	44407-44417	NN	denotes	expression
T9949	44418-44420	IN	denotes	of
T9950	44421-44431	JJ	denotes	structural
T9951	44432-44442	NNS	denotes	components
T9952	44443-44445	IN	denotes	of
T9953	44446-44455	NN	denotes	cartilage
T9954	44456-44462	NN	denotes	matrix
T9955	44462-44463	.	denotes	.
T9956	44463-44653	sentence	denotes	However, several of the most prominent structural components of cartilage matrix fail to be maintained in mutant animals, resulting in decreased synthesis of Col2a1, Agg, and proteoglycans.
T9957	44464-44471	RB	denotes	However
T9958	44545-44549	VBP	denotes	fail
T9959	44471-44473	,	denotes	,
T9960	44473-44480	JJ	denotes	several
T9961	44481-44483	IN	denotes	of
T9962	44484-44487	DT	denotes	the
T9963	44514-44524	NNS	denotes	components
T9964	44488-44492	RBS	denotes	most
T9965	44493-44502	JJ	denotes	prominent
T9966	44503-44513	JJ	denotes	structural
T9967	44525-44527	IN	denotes	of
T9968	44528-44537	NN	denotes	cartilage
T9969	44538-44544	NN	denotes	matrix
T9970	44550-44552	TO	denotes	to
T9971	44556-44566	VBN	denotes	maintained
T9972	44553-44555	VB	denotes	be
T9973	44567-44569	IN	denotes	in
T9974	44570-44576	NN	denotes	mutant
T9975	44577-44584	NNS	denotes	animals
T9976	44584-44586	,	denotes	,
T9977	44586-44595	VBG	denotes	resulting
T9978	44596-44598	IN	denotes	in
T9979	44599-44608	VBN	denotes	decreased
T9980	44609-44618	NN	denotes	synthesis
T9981	44619-44621	IN	denotes	of
T9982	44622-44628	NN	denotes	Col2a1
T9983	44628-44630	,	denotes	,
T9984	44630-44633	NN	denotes	Agg
T9985	44633-44635	,	denotes	,
T9986	44635-44638	CC	denotes	and
T9987	44639-44652	NNS	denotes	proteoglycans
T9988	44652-44653	.	denotes	.
T9989	44653-44772	sentence	denotes	Therefore, BMPR1A appears to maintain articular cartilage primarily through inducing expression of key ECM components.
T9990	44654-44663	RB	denotes	Therefore
T9991	44672-44679	VBZ	denotes	appears
T9992	44663-44665	,	denotes	,
T9993	44665-44671	NN	denotes	BMPR1A
T9994	44680-44682	TO	denotes	to
T9995	44683-44691	VB	denotes	maintain
T9996	44692-44701	JJ	denotes	articular
T9997	44702-44711	NN	denotes	cartilage
T9998	44712-44721	RB	denotes	primarily
T9999	44722-44729	IN	denotes	through
T10000	44730-44738	VBG	denotes	inducing
T10001	44739-44749	NN	denotes	expression
T10002	44750-44752	IN	denotes	of
T10003	44753-44756	JJ	denotes	key
T10004	44761-44771	NNS	denotes	components
T10005	44757-44760	NN	denotes	ECM
T10006	44771-44772	.	denotes	.
T10007	44772-44982	sentence	denotes	It is interesting that the SOX9 transcription factor continues to be expressed in mutant cartilage despite loss of Col2a1, a direct target of this transcription factor (Bell et al. 1997; Lefebvre et al. 1997).
T10008	44773-44775	PRP	denotes	It
T10009	44776-44778	VBZ	denotes	is
T10010	44779-44790	JJ	denotes	interesting
T10011	44791-44795	IN	denotes	that
T10012	44826-44835	VBZ	denotes	continues
T10013	44796-44799	DT	denotes	the
T10014	44819-44825	NN	denotes	factor
T10015	44800-44804	NN	denotes	SOX9
T10016	44805-44818	NN	denotes	transcription
T10017	44836-44838	TO	denotes	to
T10018	44842-44851	VBN	denotes	expressed
T10019	44839-44841	VB	denotes	be
T10020	44852-44854	IN	denotes	in
T10021	44855-44861	NN	denotes	mutant
T10022	44862-44871	NN	denotes	cartilage
T10023	44872-44879	IN	denotes	despite
T10024	44880-44884	NN	denotes	loss
T10025	44885-44887	IN	denotes	of
T10026	44888-44894	NN	denotes	Col2a1
T10027	44894-44896	,	denotes	,
T10028	44896-44897	DT	denotes	a
T10029	44905-44911	NN	denotes	target
T10030	44898-44904	JJ	denotes	direct
T10031	44912-44914	IN	denotes	of
T10032	44915-44919	DT	denotes	this
T10033	44934-44940	NN	denotes	factor
T10034	44920-44933	NN	denotes	transcription
T10035	44941-44942	-LRB-	denotes	(
T10036	44942-44946	NNP	denotes	Bell
T10037	44947-44949	FW	denotes	et
T10038	44950-44953	FW	denotes	al.
T10039	44954-44958	CD	denotes	1997
T10040	44958-44959	:	denotes	;
T10041	44960-44968	NNP	denotes	Lefebvre
T10042	44969-44971	FW	denotes	et
T10043	44972-44975	FW	denotes	al.
T10044	44976-44980	CD	denotes	1997
T10045	44980-44981	-RRB-	denotes	)
T10046	44981-44982	.	denotes	.
T10047	44982-45206	sentence	denotes	Previous studies suggest that SOX9 activity can be modified by protein kinase A (PKA)-dependent protein phosphorylation, or by coexpression of two related proteins, L-SOX5 and SOX6 (Lefebvre et al. 1998; Huang et al. 2000).
T10048	44983-44991	JJ	denotes	Previous
T10049	44992-44999	NNS	denotes	studies
T10050	45000-45007	VBP	denotes	suggest
T10051	45008-45012	IN	denotes	that
T10052	45034-45042	VBN	denotes	modified
T10053	45013-45017	NN	denotes	SOX9
T10054	45018-45026	NN	denotes	activity
T10055	45027-45030	MD	denotes	can
T10056	45031-45033	VB	denotes	be
T10057	45043-45045	IN	denotes	by
T10058	45046-45053	NN	denotes	protein
T10059	45061-45062	NN	denotes	A
T10060	45054-45060	NN	denotes	kinase
T10061	45069-45078	JJ	denotes	dependent
T10062	45063-45064	-LRB-	denotes	(
T10063	45064-45067	NN	denotes	PKA
T10064	45067-45068	-RRB-	denotes	)
T10065	45068-45069	HYPH	denotes	-
T10066	45087-45102	NN	denotes	phosphorylation
T10067	45079-45086	NN	denotes	protein
T10068	45102-45104	,	denotes	,
T10069	45104-45106	CC	denotes	or
T10070	45107-45109	IN	denotes	by
T10071	45110-45122	NN	denotes	coexpression
T10072	45123-45125	IN	denotes	of
T10073	45126-45129	CD	denotes	two
T10074	45138-45146	NN	denotes	proteins
T10075	45130-45137	VBN	denotes	related
T10076	45146-45148	,	denotes	,
T10077	45148-45149	NN	denotes	L
T10078	45150-45154	NN	denotes	SOX5
T10079	45149-45150	HYPH	denotes	-
T10080	45155-45158	CC	denotes	and
T10081	45159-45163	NN	denotes	SOX6
T10082	45164-45165	-LRB-	denotes	(
T10083	45165-45173	NNP	denotes	Lefebvre
T10084	45174-45176	FW	denotes	et
T10085	45177-45180	FW	denotes	al.
T10086	45181-45185	CD	denotes	1998
T10087	45185-45186	:	denotes	;
T10088	45187-45192	NNP	denotes	Huang
T10089	45193-45195	FW	denotes	et
T10090	45196-45199	FW	denotes	al.
T10091	45200-45204	CD	denotes	2000
T10092	45204-45205	-RRB-	denotes	)
T10093	45205-45206	.	denotes	.
T10094	45206-45469	sentence	denotes	In addition, close examination of the order of genes induced during chicken digit formation reveals that Sox9 turns on first, followed by Bmpr1b with L-Sox5, and then Sox6 and the cartilage matrix structural components Col2a1 and Agg (Chimal-Monroy et al. 2003).
T10095	45207-45209	IN	denotes	In
T10096	45299-45306	VBZ	denotes	reveals
T10097	45210-45218	NN	denotes	addition
T10098	45218-45220	,	denotes	,
T10099	45220-45225	JJ	denotes	close
T10100	45226-45237	NN	denotes	examination
T10101	45238-45240	IN	denotes	of
T10102	45241-45244	DT	denotes	the
T10103	45245-45250	NN	denotes	order
T10104	45251-45253	IN	denotes	of
T10105	45254-45259	NNS	denotes	genes
T10106	45260-45267	VBN	denotes	induced
T10107	45268-45274	IN	denotes	during
T10108	45275-45282	NN	denotes	chicken
T10109	45289-45298	NN	denotes	formation
T10110	45283-45288	NN	denotes	digit
T10111	45307-45311	IN	denotes	that
T10112	45317-45322	VBZ	denotes	turns
T10113	45312-45316	NN	denotes	Sox9
T10114	45323-45325	RP	denotes	on
T10115	45326-45331	RB	denotes	first
T10116	45331-45333	,	denotes	,
T10117	45333-45341	VBN	denotes	followed
T10118	45342-45344	IN	denotes	by
T10119	45345-45351	NN	denotes	Bmpr1b
T10120	45352-45356	IN	denotes	with
T10121	45357-45358	NN	denotes	L
T10122	45359-45363	NN	denotes	Sox5
T10123	45358-45359	HYPH	denotes	-
T10124	45363-45365	,	denotes	,
T10125	45365-45368	CC	denotes	and
T10126	45369-45373	RB	denotes	then
T10127	45374-45378	NN	denotes	Sox6
T10128	45379-45382	CC	denotes	and
T10129	45383-45386	DT	denotes	the
T10130	45415-45425	NNS	denotes	components
T10131	45387-45396	NN	denotes	cartilage
T10132	45397-45403	NN	denotes	matrix
T10133	45404-45414	JJ	denotes	structural
T10134	45426-45432	NN	denotes	Col2a1
T10135	45433-45436	CC	denotes	and
T10136	45437-45440	NN	denotes	Agg
T10137	45441-45442	-LRB-	denotes	(
T10138	45442-45448	NNP	denotes	Chimal
T10139	45448-45449	HYPH	denotes	-
T10140	45449-45455	NNP	denotes	Monroy
T10141	45456-45458	FW	denotes	et
T10142	45459-45462	FW	denotes	al.
T10143	45463-45467	CD	denotes	2003
T10144	45467-45468	-RRB-	denotes	)
T10145	45468-45469	.	denotes	.
T10146	45469-45764	sentence	denotes	These results, together with the altered pattern of gene expression seen in our Bmpr1a-deficient mice, suggest that BMPR1A signaling may normally act to stimulate SOX9 by post-translational protein modification, or to induce L-Sox5 or Sox6 in cartilage to maintain expression of ECM components.
T10147	45470-45475	DT	denotes	These
T10148	45476-45483	NNS	denotes	results
T10149	45573-45580	VBP	denotes	suggest
T10150	45483-45485	,	denotes	,
T10151	45485-45493	RB	denotes	together
T10152	45494-45498	IN	denotes	with
T10153	45499-45502	DT	denotes	the
T10154	45511-45518	NN	denotes	pattern
T10155	45503-45510	VBN	denotes	altered
T10156	45519-45521	IN	denotes	of
T10157	45522-45526	NN	denotes	gene
T10158	45527-45537	NN	denotes	expression
T10159	45538-45542	VBN	denotes	seen
T10160	45543-45545	IN	denotes	in
T10161	45546-45549	PRP$	denotes	our
T10162	45567-45571	NNS	denotes	mice
T10163	45550-45556	NN	denotes	Bmpr1a
T10164	45557-45566	JJ	denotes	deficient
T10165	45556-45557	HYPH	denotes	-
T10166	45571-45573	,	denotes	,
T10167	45581-45585	IN	denotes	that
T10168	45616-45619	VB	denotes	act
T10169	45586-45592	NN	denotes	BMPR1A
T10170	45593-45602	NN	denotes	signaling
T10171	45603-45606	MD	denotes	may
T10172	45607-45615	RB	denotes	normally
T10173	45620-45622	TO	denotes	to
T10174	45623-45632	VB	denotes	stimulate
T10175	45633-45637	NN	denotes	SOX9
T10176	45638-45640	IN	denotes	by
T10177	45641-45659	JJ	denotes	post-translational
T10178	45668-45680	NN	denotes	modification
T10179	45660-45667	NN	denotes	protein
T10180	45680-45682	,	denotes	,
T10181	45682-45684	CC	denotes	or
T10182	45685-45687	TO	denotes	to
T10183	45688-45694	VB	denotes	induce
T10184	45695-45696	NN	denotes	L
T10185	45697-45701	NN	denotes	Sox5
T10186	45696-45697	HYPH	denotes	-
T10187	45702-45704	CC	denotes	or
T10188	45705-45709	NN	denotes	Sox6
T10189	45710-45712	IN	denotes	in
T10190	45713-45722	NN	denotes	cartilage
T10191	45723-45725	TO	denotes	to
T10192	45726-45734	VB	denotes	maintain
T10193	45735-45745	NN	denotes	expression
T10194	45746-45748	IN	denotes	of
T10195	45749-45752	NN	denotes	ECM
T10196	45753-45763	NNS	denotes	components
T10197	45763-45764	.	denotes	.
T10198	45764-45954	sentence	denotes	These models are consistent with the ability of BMP2 to both increase PKA activity and induce expression of Sox6 in tissue culture cells (Lee and Chuong 1997; Fernandez-Lloris et al. 2003).
T10199	45765-45770	DT	denotes	These
T10200	45771-45777	NNS	denotes	models
T10201	45778-45781	VBP	denotes	are
T10202	45782-45792	JJ	denotes	consistent
T10203	45793-45797	IN	denotes	with
T10204	45798-45801	DT	denotes	the
T10205	45802-45809	NN	denotes	ability
T10206	45810-45812	IN	denotes	of
T10207	45813-45817	NN	denotes	BMP2
T10208	45818-45820	TO	denotes	to
T10209	45826-45834	VB	denotes	increase
T10210	45821-45825	CC	denotes	both
T10211	45835-45838	NN	denotes	PKA
T10212	45839-45847	NN	denotes	activity
T10213	45848-45851	CC	denotes	and
T10214	45852-45858	VB	denotes	induce
T10215	45859-45869	NN	denotes	expression
T10216	45870-45872	IN	denotes	of
T10217	45873-45877	NN	denotes	Sox6
T10218	45878-45880	IN	denotes	in
T10219	45881-45887	NN	denotes	tissue
T10220	45896-45901	NNS	denotes	cells
T10221	45888-45895	NN	denotes	culture
T10222	45902-45903	-LRB-	denotes	(
T10223	45903-45906	NNP	denotes	Lee
T10224	45907-45910	CC	denotes	and
T10225	45911-45917	NNP	denotes	Chuong
T10226	45918-45922	CD	denotes	1997
T10227	45922-45923	:	denotes	;
T10228	45924-45933	NNP	denotes	Fernandez
T10229	45933-45934	HYPH	denotes	-
T10230	45934-45940	NNP	denotes	Lloris
T10231	45941-45943	FW	denotes	et
T10232	45944-45947	FW	denotes	al.
T10233	45948-45952	CD	denotes	2003
T10234	45952-45953	-RRB-	denotes	)
T10235	45953-45954	.	denotes	.
T10236	45954-46281	sentence	denotes	Although we have tried to monitor the expression of L-Sox5 or Sox6 in postnatal articular cartilage, and test the phosphorylation state of SOX9 using previously described reagents (Lefebvre et al. 1998; Huang et al. 2000), we have been unable to obtain specific signal at the late postnatal stages required (unpublished data).
T10237	45955-45963	IN	denotes	Although
T10238	45972-45977	VBN	denotes	tried
T10239	45964-45966	PRP	denotes	we
T10240	45967-45971	VBP	denotes	have
T10241	46186-46190	VBN	denotes	been
T10242	45978-45980	TO	denotes	to
T10243	45981-45988	VB	denotes	monitor
T10244	45989-45992	DT	denotes	the
T10245	45993-46003	NN	denotes	expression
T10246	46004-46006	IN	denotes	of
T10247	46007-46008	NN	denotes	L
T10248	46009-46013	NN	denotes	Sox5
T10249	46008-46009	HYPH	denotes	-
T10250	46014-46016	CC	denotes	or
T10251	46017-46021	NN	denotes	Sox6
T10252	46022-46024	IN	denotes	in
T10253	46025-46034	JJ	denotes	postnatal
T10254	46045-46054	NN	denotes	cartilage
T10255	46035-46044	JJ	denotes	articular
T10256	46054-46056	,	denotes	,
T10257	46056-46059	CC	denotes	and
T10258	46060-46064	VB	denotes	test
T10259	46065-46068	DT	denotes	the
T10260	46085-46090	NN	denotes	state
T10261	46069-46084	NN	denotes	phosphorylation
T10262	46091-46093	IN	denotes	of
T10263	46094-46098	NN	denotes	SOX9
T10264	46099-46104	VBG	denotes	using
T10265	46105-46115	RB	denotes	previously
T10266	46116-46125	VBN	denotes	described
T10267	46126-46134	NNS	denotes	reagents
T10268	46135-46136	-LRB-	denotes	(
T10269	46136-46144	NNP	denotes	Lefebvre
T10270	46145-46147	FW	denotes	et
T10271	46148-46151	FW	denotes	al.
T10272	46152-46156	CD	denotes	1998
T10273	46156-46157	:	denotes	;
T10274	46158-46163	NNP	denotes	Huang
T10275	46164-46166	FW	denotes	et
T10276	46167-46170	FW	denotes	al.
T10277	46171-46175	CD	denotes	2000
T10278	46175-46176	-RRB-	denotes	)
T10279	46176-46178	,	denotes	,
T10280	46178-46180	PRP	denotes	we
T10281	46181-46185	VBP	denotes	have
T10282	46191-46197	JJ	denotes	unable
T10283	46198-46200	TO	denotes	to
T10284	46201-46207	VB	denotes	obtain
T10285	46208-46216	JJ	denotes	specific
T10286	46217-46223	NN	denotes	signal
T10287	46224-46226	IN	denotes	at
T10288	46227-46230	DT	denotes	the
T10289	46246-46252	NNS	denotes	stages
T10290	46231-46235	JJ	denotes	late
T10291	46236-46245	JJ	denotes	postnatal
T10292	46253-46261	VBN	denotes	required
T10293	46262-46263	-LRB-	denotes	(
T10294	46275-46279	NNS	denotes	data
T10295	46263-46274	JJ	denotes	unpublished
T10296	46279-46280	-RRB-	denotes	)
T10297	46280-46281	.	denotes	.
T10298	46281-46446	sentence	denotes	Furthermore, null mutations in L-Sox5 or Sox-6 cause lethality at or soon after birth, and no effect on cartilage maintenance has been reported (Smits et al. 2001).
T10299	46282-46293	RB	denotes	Furthermore
T10300	46329-46334	VBP	denotes	cause
T10301	46293-46295	,	denotes	,
T10302	46295-46299	JJ	denotes	null
T10303	46300-46309	NNS	denotes	mutations
T10304	46310-46312	IN	denotes	in
T10305	46313-46314	NN	denotes	L
T10306	46315-46319	NN	denotes	Sox5
T10307	46314-46315	HYPH	denotes	-
T10308	46320-46322	CC	denotes	or
T10309	46323-46326	NN	denotes	Sox
T10310	46326-46327	HYPH	denotes	-
T10311	46327-46328	CD	denotes	6
T10312	46335-46344	NN	denotes	lethality
T10313	46345-46347	IN	denotes	at
T10314	46348-46350	CC	denotes	or
T10315	46351-46355	RB	denotes	soon
T10316	46356-46361	IN	denotes	after
T10317	46362-46367	NN	denotes	birth
T10318	46367-46369	,	denotes	,
T10319	46369-46372	CC	denotes	and
T10320	46373-46375	DT	denotes	no
T10321	46376-46382	NN	denotes	effect
T10322	46417-46425	VBN	denotes	reported
T10323	46383-46385	IN	denotes	on
T10324	46386-46395	NN	denotes	cartilage
T10325	46396-46407	NN	denotes	maintenance
T10326	46408-46411	VBZ	denotes	has
T10327	46412-46416	VBN	denotes	been
T10328	46426-46427	-LRB-	denotes	(
T10329	46427-46432	NNP	denotes	Smits
T10330	46433-46435	FW	denotes	et
T10331	46436-46439	FW	denotes	al.
T10332	46440-46444	CD	denotes	2001
T10333	46444-46445	-RRB-	denotes	)
T10334	46445-46446	.	denotes	.
T10335	46446-46595	sentence	denotes	However, it seems likely that these or other processes regulated by BMP signaling cooperate with SOX9 to induce target genes in articular cartilage.
T10336	46447-46454	RB	denotes	However
T10337	46459-46464	VBZ	denotes	seems
T10338	46454-46456	,	denotes	,
T10339	46456-46458	PRP	denotes	it
T10340	46465-46471	JJ	denotes	likely
T10341	46472-46476	IN	denotes	that
T10342	46529-46538	VBP	denotes	cooperate
T10343	46477-46482	DT	denotes	these
T10344	46483-46485	CC	denotes	or
T10345	46486-46491	JJ	denotes	other
T10346	46492-46501	NNS	denotes	processes
T10347	46502-46511	VBN	denotes	regulated
T10348	46512-46514	IN	denotes	by
T10349	46515-46518	NN	denotes	BMP
T10350	46519-46528	NN	denotes	signaling
T10351	46539-46543	IN	denotes	with
T10352	46544-46548	NN	denotes	SOX9
T10353	46549-46551	TO	denotes	to
T10354	46552-46558	VB	denotes	induce
T10355	46559-46565	JJ	denotes	target
T10356	46566-46571	NNS	denotes	genes
T10357	46572-46574	IN	denotes	in
T10358	46575-46584	JJ	denotes	articular
T10359	46585-46594	NN	denotes	cartilage
T10360	46594-46595	.	denotes	.
T10361	46595-46794	sentence	denotes	Mutation of Smad3 or expression of dominant negative transforming growth factor β (TGF-β) type II receptor also disrupts normal articular cartilage maintenance (Serra et al. 1997; Yang et al. 2001).
T10362	46596-46604	NN	denotes	Mutation
T10363	46708-46716	VBZ	denotes	disrupts
T10364	46605-46607	IN	denotes	of
T10365	46608-46613	NN	denotes	Smad3
T10366	46614-46616	CC	denotes	or
T10367	46617-46627	NN	denotes	expression
T10368	46628-46630	IN	denotes	of
T10369	46631-46639	JJ	denotes	dominant
T10370	46694-46702	NN	denotes	receptor
T10371	46640-46648	JJ	denotes	negative
T10372	46649-46661	VBG	denotes	transforming
T10373	46676-46677	NN	denotes	β
T10374	46662-46668	NN	denotes	growth
T10375	46669-46675	NN	denotes	factor
T10376	46678-46679	-LRB-	denotes	(
T10377	46679-46682	NN	denotes	TGF
T10378	46683-46684	NN	denotes	β
T10379	46682-46683	HYPH	denotes	-
T10380	46684-46685	-RRB-	denotes	)
T10381	46686-46690	NN	denotes	type
T10382	46691-46693	CD	denotes	II
T10383	46703-46707	RB	denotes	also
T10384	46717-46723	JJ	denotes	normal
T10385	46744-46755	NN	denotes	maintenance
T10386	46724-46733	JJ	denotes	articular
T10387	46734-46743	NN	denotes	cartilage
T10388	46756-46757	-LRB-	denotes	(
T10389	46757-46762	NNP	denotes	Serra
T10390	46763-46765	FW	denotes	et
T10391	46766-46769	FW	denotes	al.
T10392	46770-46774	CD	denotes	1997
T10393	46774-46775	:	denotes	;
T10394	46776-46780	NNP	denotes	Yang
T10395	46781-46783	FW	denotes	et
T10396	46784-46787	FW	denotes	al.
T10397	46788-46792	CD	denotes	2001
T10398	46792-46793	-RRB-	denotes	)
T10399	46793-46794	.	denotes	.
T10400	46794-46949	sentence	denotes	Both manipulations should disrupt TGFβ rather than BMP signaling, and both manipulations cause articular cartilage to hypertrophy and be replaced by bone.
T10401	46795-46799	DT	denotes	Both
T10402	46800-46813	NNS	denotes	manipulations
T10403	46821-46828	VB	denotes	disrupt
T10404	46814-46820	MD	denotes	should
T10405	46829-46833	NN	denotes	TGFβ
T10406	46834-46840	JJ	denotes	rather
T10407	46841-46845	IN	denotes	than
T10408	46846-46849	NN	denotes	BMP
T10409	46850-46859	NN	denotes	signaling
T10410	46859-46861	,	denotes	,
T10411	46861-46864	CC	denotes	and
T10412	46865-46869	DT	denotes	both
T10413	46870-46883	NNS	denotes	manipulations
T10414	46884-46889	VBP	denotes	cause
T10415	46890-46899	JJ	denotes	articular
T10416	46900-46909	NN	denotes	cartilage
T10417	46913-46924	VB	denotes	hypertrophy
T10418	46910-46912	TO	denotes	to
T10419	46925-46928	CC	denotes	and
T10420	46929-46931	VB	denotes	be
T10421	46932-46940	VBN	denotes	replaced
T10422	46941-46943	IN	denotes	by
T10423	46944-46948	NN	denotes	bone
T10424	46948-46949	.	denotes	.
T10425	46949-47094	sentence	denotes	In contrast, our analysis of Bmpr1a mutant articular cartilage showed a loss of ECM components, but no signs of hypertrophy or bone replacement.
T10426	46950-46952	IN	denotes	In
T10427	47013-47019	VBD	denotes	showed
T10428	46953-46961	NN	denotes	contrast
T10429	46961-46963	,	denotes	,
T10430	46963-46966	PRP$	denotes	our
T10431	46967-46975	NN	denotes	analysis
T10432	46976-46978	IN	denotes	of
T10433	46979-46985	NN	denotes	Bmpr1a
T10434	46986-46992	NN	denotes	mutant
T10435	47003-47012	NN	denotes	cartilage
T10436	46993-47002	JJ	denotes	articular
T10437	47020-47021	DT	denotes	a
T10438	47022-47026	NN	denotes	loss
T10439	47027-47029	IN	denotes	of
T10440	47030-47033	NN	denotes	ECM
T10441	47034-47044	NNS	denotes	components
T10442	47044-47046	,	denotes	,
T10443	47046-47049	CC	denotes	but
T10444	47050-47052	DT	denotes	no
T10445	47053-47058	NNS	denotes	signs
T10446	47059-47061	IN	denotes	of
T10447	47062-47073	NN	denotes	hypertrophy
T10448	47074-47076	CC	denotes	or
T10449	47077-47081	NN	denotes	bone
T10450	47082-47093	NN	denotes	replacement
T10451	47093-47094	.	denotes	.
T10452	47094-47202	sentence	denotes	Therefore, TGFβ and BMP signaling are playing distinct but necessary roles to maintain articular cartilage.
T10453	47095-47104	RB	denotes	Therefore
T10454	47133-47140	VBG	denotes	playing
T10455	47104-47106	,	denotes	,
T10456	47106-47110	NN	denotes	TGFβ
T10457	47119-47128	NN	denotes	signaling
T10458	47111-47114	CC	denotes	and
T10459	47115-47118	NN	denotes	BMP
T10460	47129-47132	VBP	denotes	are
T10461	47141-47149	JJ	denotes	distinct
T10462	47164-47169	NNS	denotes	roles
T10463	47150-47153	CC	denotes	but
T10464	47154-47163	JJ	denotes	necessary
T10465	47170-47172	TO	denotes	to
T10466	47173-47181	VB	denotes	maintain
T10467	47182-47191	JJ	denotes	articular
T10468	47192-47201	NN	denotes	cartilage
T10469	47201-47202	.	denotes	.
T10470	47202-47586	sentence	denotes	Although BMPs were originally isolated on the basis of their ability to induce ectopic bone formation, their presence in articular cartilage and strong effect on cartilage formation has stimulated interest in using them to repair or regenerate cartilage defects in adult animals (Chang et al. 1994; Erlacher et al. 1998; Edwards and Francis-West 2001; Chubinskaya and Kuettner 2003).
T10471	47203-47211	IN	denotes	Although
T10472	47233-47241	VBN	denotes	isolated
T10473	47212-47216	NNS	denotes	BMPs
T10474	47217-47221	VBD	denotes	were
T10475	47222-47232	RB	denotes	originally
T10476	47389-47399	VBN	denotes	stimulated
T10477	47242-47244	IN	denotes	on
T10478	47245-47248	DT	denotes	the
T10479	47249-47254	NN	denotes	basis
T10480	47255-47257	IN	denotes	of
T10481	47258-47263	PRP$	denotes	their
T10482	47264-47271	NN	denotes	ability
T10483	47272-47274	TO	denotes	to
T10484	47275-47281	VB	denotes	induce
T10485	47282-47289	JJ	denotes	ectopic
T10486	47295-47304	NN	denotes	formation
T10487	47290-47294	NN	denotes	bone
T10488	47304-47306	,	denotes	,
T10489	47306-47311	PRP$	denotes	their
T10490	47312-47320	NN	denotes	presence
T10491	47321-47323	IN	denotes	in
T10492	47324-47333	JJ	denotes	articular
T10493	47334-47343	NN	denotes	cartilage
T10494	47344-47347	CC	denotes	and
T10495	47348-47354	JJ	denotes	strong
T10496	47355-47361	NN	denotes	effect
T10497	47362-47364	IN	denotes	on
T10498	47365-47374	NN	denotes	cartilage
T10499	47375-47384	NN	denotes	formation
T10500	47385-47388	VBZ	denotes	has
T10501	47400-47408	NN	denotes	interest
T10502	47409-47411	IN	denotes	in
T10503	47412-47417	VBG	denotes	using
T10504	47418-47422	PRP	denotes	them
T10505	47423-47425	TO	denotes	to
T10506	47426-47432	VB	denotes	repair
T10507	47433-47435	CC	denotes	or
T10508	47436-47446	VB	denotes	regenerate
T10509	47447-47456	NN	denotes	cartilage
T10510	47457-47464	NNS	denotes	defects
T10511	47465-47467	IN	denotes	in
T10512	47468-47473	NN	denotes	adult
T10513	47474-47481	NNS	denotes	animals
T10514	47482-47483	-LRB-	denotes	(
T10515	47483-47488	NNP	denotes	Chang
T10516	47489-47491	FW	denotes	et
T10517	47492-47495	FW	denotes	al.
T10518	47496-47500	CD	denotes	1994
T10519	47500-47501	:	denotes	;
T10520	47502-47510	NNP	denotes	Erlacher
T10521	47511-47513	FW	denotes	et
T10522	47514-47517	FW	denotes	al.
T10523	47518-47522	CD	denotes	1998
T10524	47522-47523	:	denotes	;
T10525	47524-47531	NNP	denotes	Edwards
T10526	47532-47535	CC	denotes	and
T10527	47536-47543	NNP	denotes	Francis
T10528	47543-47544	HYPH	denotes	-
T10529	47544-47548	NNP	denotes	West
T10530	47549-47553	CD	denotes	2001
T10531	47553-47554	:	denotes	;
T10532	47555-47566	NNP	denotes	Chubinskaya
T10533	47567-47570	CC	denotes	and
T10534	47571-47579	NNP	denotes	Kuettner
T10535	47580-47584	CD	denotes	2003
T10536	47584-47585	-RRB-	denotes	)
T10537	47585-47586	.	denotes	.
T10538	47586-47900	sentence	denotes	The failure to maintain articular cartilage in the absence of normal BMPR1A function suggests that ligands or small molecule agonists that interact specifically with this receptor subtype may be particularly good candidates for designing new approaches to maintain or heal articular cartilage at postnatal stages.
T10539	47587-47590	DT	denotes	The
T10540	47591-47598	NN	denotes	failure
T10541	47672-47680	VBZ	denotes	suggests
T10542	47599-47601	TO	denotes	to
T10543	47602-47610	VB	denotes	maintain
T10544	47611-47620	JJ	denotes	articular
T10545	47621-47630	NN	denotes	cartilage
T10546	47631-47633	IN	denotes	in
T10547	47634-47637	DT	denotes	the
T10548	47638-47645	NN	denotes	absence
T10549	47646-47648	IN	denotes	of
T10550	47649-47655	JJ	denotes	normal
T10551	47663-47671	NN	denotes	function
T10552	47656-47662	NN	denotes	BMPR1A
T10553	47681-47685	IN	denotes	that
T10554	47779-47781	VB	denotes	be
T10555	47686-47693	NNS	denotes	ligands
T10556	47694-47696	CC	denotes	or
T10557	47697-47702	JJ	denotes	small
T10558	47712-47720	NNS	denotes	agonists
T10559	47703-47711	NN	denotes	molecule
T10560	47721-47725	WDT	denotes	that
T10561	47726-47734	VBP	denotes	interact
T10562	47735-47747	RB	denotes	specifically
T10563	47748-47752	IN	denotes	with
T10564	47753-47757	DT	denotes	this
T10565	47767-47774	NN	denotes	subtype
T10566	47758-47766	NN	denotes	receptor
T10567	47775-47778	MD	denotes	may
T10568	47782-47794	RB	denotes	particularly
T10569	47795-47799	JJ	denotes	good
T10570	47800-47810	NNS	denotes	candidates
T10571	47811-47814	IN	denotes	for
T10572	47815-47824	VBG	denotes	designing
T10573	47825-47828	JJ	denotes	new
T10574	47829-47839	NNS	denotes	approaches
T10575	47840-47842	TO	denotes	to
T10576	47843-47851	VB	denotes	maintain
T10577	47852-47854	CC	denotes	or
T10578	47855-47859	VB	denotes	heal
T10579	47860-47869	JJ	denotes	articular
T10580	47870-47879	NN	denotes	cartilage
T10581	47880-47882	IN	denotes	at
T10582	47883-47892	JJ	denotes	postnatal
T10583	47893-47899	NNS	denotes	stages
T10584	47899-47900	.	denotes	.
T10585	47900-48031	sentence	denotes	Lack of Bmpr1a function in articular cartilage results in severe fibrillation of the articular surface and loss of joint mobility.
T10586	47901-47905	NN	denotes	Lack
T10587	47948-47955	VBZ	denotes	results
T10588	47906-47908	IN	denotes	of
T10589	47909-47915	NN	denotes	Bmpr1a
T10590	47916-47924	NN	denotes	function
T10591	47925-47927	IN	denotes	in
T10592	47928-47937	JJ	denotes	articular
T10593	47938-47947	NN	denotes	cartilage
T10594	47956-47958	IN	denotes	in
T10595	47959-47965	JJ	denotes	severe
T10596	47966-47978	NN	denotes	fibrillation
T10597	47979-47981	IN	denotes	of
T10598	47982-47985	DT	denotes	the
T10599	47996-48003	NN	denotes	surface
T10600	47986-47995	JJ	denotes	articular
T10601	48004-48007	CC	denotes	and
T10602	48008-48012	NN	denotes	loss
T10603	48013-48015	IN	denotes	of
T10604	48016-48021	NN	denotes	joint
T10605	48022-48030	NN	denotes	mobility
T10606	48030-48031	.	denotes	.
T10607	48031-48194	sentence	denotes	The development of severe arthritis symptoms in Bmpr1a-deficient mice raises the possibility that defects in BMP signaling also contribute to human joint disease.
T10608	48032-48035	DT	denotes	The
T10609	48036-48047	NN	denotes	development
T10610	48102-48108	VBZ	denotes	raises
T10611	48048-48050	IN	denotes	of
T10612	48051-48057	JJ	denotes	severe
T10613	48068-48076	NNS	denotes	symptoms
T10614	48058-48067	NN	denotes	arthritis
T10615	48077-48079	IN	denotes	in
T10616	48080-48086	NN	denotes	Bmpr1a
T10617	48087-48096	JJ	denotes	deficient
T10618	48086-48087	HYPH	denotes	-
T10619	48097-48101	NNS	denotes	mice
T10620	48109-48112	DT	denotes	the
T10621	48113-48124	NN	denotes	possibility
T10622	48125-48129	IN	denotes	that
T10623	48160-48170	VBP	denotes	contribute
T10624	48130-48137	NNS	denotes	defects
T10625	48138-48140	IN	denotes	in
T10626	48141-48144	NN	denotes	BMP
T10627	48145-48154	NN	denotes	signaling
T10628	48155-48159	RB	denotes	also
T10629	48171-48173	IN	denotes	to
T10630	48174-48179	JJ	denotes	human
T10631	48186-48193	NN	denotes	disease
T10632	48180-48185	NN	denotes	joint
T10633	48193-48194	.	denotes	.
T10634	48194-48407	sentence	denotes	Osteoarthritis is known to have a significant genetic component, but it likely involves multiple genetic factors that have been difficult to identify (Spector et al. 1996; Felson et al. 1998; Hirsch et al. 1998).
T10635	48195-48209	NN	denotes	Osteoarthritis
T10636	48213-48218	VBN	denotes	known
T10637	48210-48212	VBZ	denotes	is
T10638	48219-48221	TO	denotes	to
T10639	48222-48226	VB	denotes	have
T10640	48227-48228	DT	denotes	a
T10641	48249-48258	NN	denotes	component
T10642	48229-48240	JJ	denotes	significant
T10643	48241-48248	JJ	denotes	genetic
T10644	48258-48260	,	denotes	,
T10645	48260-48263	CC	denotes	but
T10646	48264-48266	PRP	denotes	it
T10647	48274-48282	VBZ	denotes	involves
T10648	48267-48273	RB	denotes	likely
T10649	48283-48291	JJ	denotes	multiple
T10650	48300-48307	NNS	denotes	factors
T10651	48292-48299	JJ	denotes	genetic
T10652	48308-48312	WDT	denotes	that
T10653	48318-48322	VBN	denotes	been
T10654	48313-48317	VBP	denotes	have
T10655	48323-48332	JJ	denotes	difficult
T10656	48333-48335	TO	denotes	to
T10657	48336-48344	VB	denotes	identify
T10658	48345-48346	-LRB-	denotes	(
T10659	48346-48353	NNP	denotes	Spector
T10660	48354-48356	FW	denotes	et
T10661	48357-48360	FW	denotes	al.
T10662	48361-48365	CD	denotes	1996
T10663	48365-48366	:	denotes	;
T10664	48367-48373	NNP	denotes	Felson
T10665	48374-48376	FW	denotes	et
T10666	48377-48380	FW	denotes	al.
T10667	48381-48385	CD	denotes	1998
T10668	48385-48386	:	denotes	;
T10669	48387-48393	NNP	denotes	Hirsch
T10670	48394-48396	FW	denotes	et
T10671	48397-48400	FW	denotes	al.
T10672	48401-48405	CD	denotes	1998
T10673	48405-48406	-RRB-	denotes	)
T10674	48406-48407	.	denotes	.
T10675	48407-48633	sentence	denotes	Humans that are heterozygous for loss-of-function mutations in BMPR1A are known to be at risk for juvenile polyposis (Howe et al. 2001; Zhou et al. 2001), but the risk of osteoarthritis for these people has not been reported.
T10676	48408-48414	NNS	denotes	Humans
T10677	48482-48487	VBN	denotes	known
T10678	48415-48419	WDT	denotes	that
T10679	48420-48423	VBP	denotes	are
T10680	48424-48436	JJ	denotes	heterozygous
T10681	48437-48440	IN	denotes	for
T10682	48441-48445	NN	denotes	loss
T10683	48458-48467	NNS	denotes	mutations
T10684	48445-48446	HYPH	denotes	-
T10685	48446-48448	IN	denotes	of
T10686	48448-48449	HYPH	denotes	-
T10687	48449-48457	NN	denotes	function
T10688	48468-48470	IN	denotes	in
T10689	48471-48477	NN	denotes	BMPR1A
T10690	48478-48481	VBP	denotes	are
T10691	48488-48490	TO	denotes	to
T10692	48491-48493	VB	denotes	be
T10693	48494-48496	IN	denotes	at
T10694	48497-48501	NN	denotes	risk
T10695	48502-48505	IN	denotes	for
T10696	48506-48514	JJ	denotes	juvenile
T10697	48515-48524	NN	denotes	polyposis
T10698	48525-48526	-LRB-	denotes	(
T10699	48526-48530	NNP	denotes	Howe
T10700	48531-48533	FW	denotes	et
T10701	48534-48537	FW	denotes	al.
T10702	48538-48542	CD	denotes	2001
T10703	48542-48543	:	denotes	;
T10704	48544-48548	NNP	denotes	Zhou
T10705	48549-48551	FW	denotes	et
T10706	48552-48555	FW	denotes	al.
T10707	48556-48560	CD	denotes	2001
T10708	48560-48561	-RRB-	denotes	)
T10709	48561-48563	,	denotes	,
T10710	48563-48566	CC	denotes	but
T10711	48567-48570	DT	denotes	the
T10712	48571-48575	NN	denotes	risk
T10713	48624-48632	VBN	denotes	reported
T10714	48576-48578	IN	denotes	of
T10715	48579-48593	NN	denotes	osteoarthritis
T10716	48594-48597	IN	denotes	for
T10717	48598-48603	DT	denotes	these
T10718	48604-48610	NNS	denotes	people
T10719	48611-48614	VBZ	denotes	has
T10720	48615-48618	RB	denotes	not
T10721	48619-48623	VBN	denotes	been
T10722	48632-48633	.	denotes	.
T10723	48633-48790	sentence	denotes	However, the control mice used in this study were heterozygous for a null allele of Bmpr1a, and they showed little sign of osteoarthritis even late in life.
T10724	48634-48641	RB	denotes	However
T10725	48679-48683	VBD	denotes	were
T10726	48641-48643	,	denotes	,
T10727	48643-48646	DT	denotes	the
T10728	48655-48659	NNS	denotes	mice
T10729	48647-48654	NN	denotes	control
T10730	48660-48664	VBN	denotes	used
T10731	48665-48667	IN	denotes	in
T10732	48668-48672	DT	denotes	this
T10733	48673-48678	NN	denotes	study
T10734	48684-48696	JJ	denotes	heterozygous
T10735	48697-48700	IN	denotes	for
T10736	48701-48702	DT	denotes	a
T10737	48708-48714	NN	denotes	allele
T10738	48703-48707	JJ	denotes	null
T10739	48715-48717	IN	denotes	of
T10740	48718-48724	NN	denotes	Bmpr1a
T10741	48724-48726	,	denotes	,
T10742	48726-48729	CC	denotes	and
T10743	48730-48734	PRP	denotes	they
T10744	48735-48741	VBD	denotes	showed
T10745	48742-48748	JJ	denotes	little
T10746	48749-48753	NN	denotes	sign
T10747	48754-48756	IN	denotes	of
T10748	48757-48771	NN	denotes	osteoarthritis
T10749	48772-48776	RB	denotes	even
T10750	48777-48781	RB	denotes	late
T10751	48782-48784	IN	denotes	in
T10752	48785-48789	NN	denotes	life
T10753	48789-48790	.	denotes	.
T10754	48790-48959	sentence	denotes	Several chromosome regions have been previously linked to arthritis phenotypes in humans using either association studies in populations or linkage studies in families.
T10755	48791-48798	JJ	denotes	Several
T10756	48810-48817	NNS	denotes	regions
T10757	48799-48809	NN	denotes	chromosome
T10758	48839-48845	VBN	denotes	linked
T10759	48818-48822	VBP	denotes	have
T10760	48823-48827	VBN	denotes	been
T10761	48828-48838	RB	denotes	previously
T10762	48846-48848	IN	denotes	to
T10763	48849-48858	NN	denotes	arthritis
T10764	48859-48869	NNS	denotes	phenotypes
T10765	48870-48872	IN	denotes	in
T10766	48873-48879	NNS	denotes	humans
T10767	48880-48885	VBG	denotes	using
T10768	48886-48892	CC	denotes	either
T10769	48905-48912	NNS	denotes	studies
T10770	48893-48904	NN	denotes	association
T10771	48913-48915	IN	denotes	in
T10772	48916-48927	NNS	denotes	populations
T10773	48928-48930	CC	denotes	or
T10774	48931-48938	NN	denotes	linkage
T10775	48939-48946	NNS	denotes	studies
T10776	48947-48949	IN	denotes	in
T10777	48950-48958	NNS	denotes	families
T10778	48958-48959	.	denotes	.
T10779	48959-49329	sentence	denotes	It is interesting to note that several of these chromosome regions contain genes encoding different members of the BMP signaling pathway, including the BMP5 gene on human chromosome 6p12 (Loughlin et al. 2002), the MADH1 gene on human chromosome 4q26–4q31 (Leppavuori et al. 1999; Kent et al. 2002), and the BMPR2 receptor on human chromosome 2q33 (Wright et al. 1996).
T10780	48960-48962	PRP	denotes	It
T10781	48963-48965	VBZ	denotes	is
T10782	48966-48977	JJ	denotes	interesting
T10783	48978-48980	TO	denotes	to
T10784	48981-48985	VB	denotes	note
T10785	48986-48990	IN	denotes	that
T10786	49027-49034	VBP	denotes	contain
T10787	48991-48998	JJ	denotes	several
T10788	48999-49001	IN	denotes	of
T10789	49002-49007	DT	denotes	these
T10790	49019-49026	NNS	denotes	regions
T10791	49008-49018	NN	denotes	chromosome
T10792	49035-49040	NNS	denotes	genes
T10793	49041-49049	VBG	denotes	encoding
T10794	49050-49059	JJ	denotes	different
T10795	49060-49067	NNS	denotes	members
T10796	49068-49070	IN	denotes	of
T10797	49071-49074	DT	denotes	the
T10798	49089-49096	NN	denotes	pathway
T10799	49075-49078	NN	denotes	BMP
T10800	49079-49088	NN	denotes	signaling
T10801	49096-49098	,	denotes	,
T10802	49098-49107	VBG	denotes	including
T10803	49108-49111	DT	denotes	the
T10804	49117-49121	NN	denotes	gene
T10805	49112-49116	NN	denotes	BMP5
T10806	49122-49124	IN	denotes	on
T10807	49125-49130	JJ	denotes	human
T10808	49142-49146	NN	denotes	6p12
T10809	49131-49141	NN	denotes	chromosome
T10810	49147-49148	-LRB-	denotes	(
T10811	49148-49156	NNP	denotes	Loughlin
T10812	49157-49159	FW	denotes	et
T10813	49160-49163	FW	denotes	al.
T10814	49164-49168	CD	denotes	2002
T10815	49168-49169	-RRB-	denotes	)
T10816	49169-49171	,	denotes	,
T10817	49171-49174	DT	denotes	the
T10818	49181-49185	NN	denotes	gene
T10819	49175-49180	NN	denotes	MADH1
T10820	49186-49188	IN	denotes	on
T10821	49189-49194	JJ	denotes	human
T10822	49206-49210	NN	denotes	4q26
T10823	49195-49205	NN	denotes	chromosome
T10824	49210-49211	SYM	denotes	–
T10825	49211-49215	NN	denotes	4q31
T10826	49216-49217	-LRB-	denotes	(
T10827	49217-49227	NNP	denotes	Leppavuori
T10828	49228-49230	FW	denotes	et
T10829	49231-49234	FW	denotes	al.
T10830	49235-49239	CD	denotes	1999
T10831	49239-49240	:	denotes	;
T10832	49241-49245	NNP	denotes	Kent
T10833	49246-49248	FW	denotes	et
T10834	49249-49252	FW	denotes	al.
T10835	49253-49257	CD	denotes	2002
T10836	49257-49258	-RRB-	denotes	)
T10837	49258-49260	,	denotes	,
T10838	49260-49263	CC	denotes	and
T10839	49264-49267	DT	denotes	the
T10840	49274-49282	NN	denotes	receptor
T10841	49268-49273	NN	denotes	BMPR2
T10842	49283-49285	IN	denotes	on
T10843	49286-49291	JJ	denotes	human
T10844	49303-49307	NN	denotes	2q33
T10845	49292-49302	NN	denotes	chromosome
T10846	49308-49309	-LRB-	denotes	(
T10847	49309-49315	NNP	denotes	Wright
T10848	49316-49318	FW	denotes	et
T10849	49319-49322	FW	denotes	al.
T10850	49323-49327	CD	denotes	1996
T10851	49327-49328	-RRB-	denotes	)
T10852	49328-49329	.	denotes	.
T10853	49329-49482	sentence	denotes	The complex nature of human osteoarthritis suggests that interactions between multiple genes may be involved in modifying susceptibility to the disease.
T10854	49330-49333	DT	denotes	The
T10855	49342-49348	NN	denotes	nature
T10856	49334-49341	JJ	denotes	complex
T10857	49373-49381	VBZ	denotes	suggests
T10858	49349-49351	IN	denotes	of
T10859	49352-49357	JJ	denotes	human
T10860	49358-49372	NN	denotes	osteoarthritis
T10861	49382-49386	IN	denotes	that
T10862	49430-49438	VBN	denotes	involved
T10863	49387-49399	NNS	denotes	interactions
T10864	49400-49407	IN	denotes	between
T10865	49408-49416	JJ	denotes	multiple
T10866	49417-49422	NNS	denotes	genes
T10867	49423-49426	MD	denotes	may
T10868	49427-49429	VB	denotes	be
T10869	49439-49441	IN	denotes	in
T10870	49442-49451	VBG	denotes	modifying
T10871	49452-49466	NN	denotes	susceptibility
T10872	49467-49469	IN	denotes	to
T10873	49470-49473	DT	denotes	the
T10874	49474-49481	NN	denotes	disease
T10875	49481-49482	.	denotes	.
T10876	49482-49660	sentence	denotes	The inclusion of genetic markers near BMP signaling components may help identify additional osteoarthritis susceptibility loci and facilitate the search for causative mutations.
T10877	49483-49486	DT	denotes	The
T10878	49487-49496	NN	denotes	inclusion
T10879	49550-49554	VB	denotes	help
T10880	49497-49499	IN	denotes	of
T10881	49500-49507	JJ	denotes	genetic
T10882	49508-49515	NNS	denotes	markers
T10883	49516-49520	IN	denotes	near
T10884	49521-49524	NN	denotes	BMP
T10885	49535-49545	NNS	denotes	components
T10886	49525-49534	NN	denotes	signaling
T10887	49546-49549	MD	denotes	may
T10888	49555-49563	VB	denotes	identify
T10889	49564-49574	JJ	denotes	additional
T10890	49605-49609	NNS	denotes	loci
T10891	49575-49589	NN	denotes	osteoarthritis
T10892	49590-49604	NN	denotes	susceptibility
T10893	49610-49613	CC	denotes	and
T10894	49614-49624	VB	denotes	facilitate
T10895	49625-49628	DT	denotes	the
T10896	49629-49635	NN	denotes	search
T10897	49636-49639	IN	denotes	for
T10898	49640-49649	JJ	denotes	causative
T10899	49650-49659	NNS	denotes	mutations
T10900	49659-49660	.	denotes	.
T10901	49660-49859	sentence	denotes	Development and disease processes in synovial joints have been difficult to study genetically, because synovial joints are generated and function at relatively late stages of vertebrate development.
T10902	49661-49672	NN	denotes	Development
T10903	49685-49694	NNS	denotes	processes
T10904	49673-49676	CC	denotes	and
T10905	49677-49684	NN	denotes	disease
T10906	49719-49723	VBN	denotes	been
T10907	49695-49697	IN	denotes	in
T10908	49698-49706	JJ	denotes	synovial
T10909	49707-49713	NNS	denotes	joints
T10910	49714-49718	VBP	denotes	have
T10911	49724-49733	JJ	denotes	difficult
T10912	49734-49736	TO	denotes	to
T10913	49737-49742	VB	denotes	study
T10914	49743-49754	RB	denotes	genetically
T10915	49754-49756	,	denotes	,
T10916	49756-49763	IN	denotes	because
T10917	49784-49793	VBN	denotes	generated
T10918	49764-49772	JJ	denotes	synovial
T10919	49773-49779	NNS	denotes	joints
T10920	49780-49783	VBP	denotes	are
T10921	49794-49797	CC	denotes	and
T10922	49798-49806	VBP	denotes	function
T10923	49807-49809	IN	denotes	at
T10924	49810-49820	RB	denotes	relatively
T10925	49821-49825	JJ	denotes	late
T10926	49826-49832	NNS	denotes	stages
T10927	49833-49835	IN	denotes	of
T10928	49836-49846	NN	denotes	vertebrate
T10929	49847-49858	NN	denotes	development
T10930	49858-49859	.	denotes	.
T10931	49859-50053	sentence	denotes	The Gdf5-Cre system provides a new method for restricting gene expression or inactivation primarily to articular regions, thus avoiding the pleiotropic functions of many genes in other tissues.
T10932	49860-49863	DT	denotes	The
T10933	49873-49879	NN	denotes	system
T10934	49864-49868	NN	denotes	Gdf5
T10935	49869-49872	NN	denotes	Cre
T10936	49868-49869	HYPH	denotes	-
T10937	49880-49888	VBZ	denotes	provides
T10938	49889-49890	DT	denotes	a
T10939	49895-49901	NN	denotes	method
T10940	49891-49894	JJ	denotes	new
T10941	49902-49905	IN	denotes	for
T10942	49906-49917	VBG	denotes	restricting
T10943	49918-49922	NN	denotes	gene
T10944	49923-49933	NN	denotes	expression
T10945	49934-49936	CC	denotes	or
T10946	49937-49949	NN	denotes	inactivation
T10947	49950-49959	RB	denotes	primarily
T10948	49960-49962	IN	denotes	to
T10949	49963-49972	JJ	denotes	articular
T10950	49973-49980	NNS	denotes	regions
T10951	49980-49982	,	denotes	,
T10952	49982-49986	RB	denotes	thus
T10953	49987-49995	VBG	denotes	avoiding
T10954	49996-49999	DT	denotes	the
T10955	50012-50021	NNS	denotes	functions
T10956	50000-50011	JJ	denotes	pleiotropic
T10957	50022-50024	IN	denotes	of
T10958	50025-50029	JJ	denotes	many
T10959	50030-50035	NNS	denotes	genes
T10960	50036-50038	IN	denotes	in
T10961	50039-50044	JJ	denotes	other
T10962	50045-50052	NNS	denotes	tissues
T10963	50052-50053	.	denotes	.
T10964	50053-50299	sentence	denotes	Depending on the configuration of the floxed target gene, this system can be used to either activate the expression of a gene primarily in developing joints (ssee Figure 1B–1D), or to inactivate gene function in articular regions (see Figure 3).
T10965	50054-50063	VBG	denotes	Depending
T10966	50131-50135	VBN	denotes	used
T10967	50064-50066	IN	denotes	on
T10968	50067-50070	DT	denotes	the
T10969	50071-50084	NN	denotes	configuration
T10970	50085-50087	IN	denotes	of
T10971	50088-50091	DT	denotes	the
T10972	50106-50110	NN	denotes	gene
T10973	50092-50098	VBN	denotes	floxed
T10974	50099-50105	NN	denotes	target
T10975	50110-50112	,	denotes	,
T10976	50112-50116	DT	denotes	this
T10977	50117-50123	NN	denotes	system
T10978	50124-50127	MD	denotes	can
T10979	50128-50130	VB	denotes	be
T10980	50136-50138	TO	denotes	to
T10981	50146-50154	VB	denotes	activate
T10982	50139-50145	CC	denotes	either
T10983	50155-50158	DT	denotes	the
T10984	50159-50169	NN	denotes	expression
T10985	50170-50172	IN	denotes	of
T10986	50173-50174	DT	denotes	a
T10987	50175-50179	NN	denotes	gene
T10988	50180-50189	RB	denotes	primarily
T10989	50190-50192	IN	denotes	in
T10990	50193-50203	VBG	denotes	developing
T10991	50204-50210	NNS	denotes	joints
T10992	50211-50212	-LRB-	denotes	(
T10993	50212-50216	VB	denotes	ssee
T10994	50217-50223	NN	denotes	Figure
T10995	50224-50226	CD	denotes	1B
T10996	50226-50227	SYM	denotes	–
T10997	50227-50229	CD	denotes	1D
T10998	50229-50230	-RRB-	denotes	)
T10999	50230-50232	,	denotes	,
T11000	50232-50234	CC	denotes	or
T11001	50235-50237	TO	denotes	to
T11002	50238-50248	VB	denotes	inactivate
T11003	50249-50253	NN	denotes	gene
T11004	50254-50262	NN	denotes	function
T11005	50263-50265	IN	denotes	in
T11006	50266-50275	JJ	denotes	articular
T11007	50276-50283	NNS	denotes	regions
T11008	50284-50285	-LRB-	denotes	(
T11009	50285-50288	VB	denotes	see
T11010	50289-50295	NN	denotes	Figure
T11011	50296-50297	CD	denotes	3
T11012	50297-50298	-RRB-	denotes	)
T11013	50298-50299	.	denotes	.
T11014	50299-50514	sentence	denotes	Additional studies with this system should greatly enhance our knowledge of the development, function, and disease mechanisms of joints, and may bring us closer to better prevention and treatment of joint diseases.
T11015	50300-50310	JJ	denotes	Additional
T11016	50311-50318	NNS	denotes	studies
T11017	50351-50358	VB	denotes	enhance
T11018	50319-50323	IN	denotes	with
T11019	50324-50328	DT	denotes	this
T11020	50329-50335	NN	denotes	system
T11021	50336-50342	MD	denotes	should
T11022	50343-50350	RB	denotes	greatly
T11023	50359-50362	PRP$	denotes	our
T11024	50363-50372	NN	denotes	knowledge
T11025	50373-50375	IN	denotes	of
T11026	50376-50379	DT	denotes	the
T11027	50415-50425	NNS	denotes	mechanisms
T11028	50380-50391	NN	denotes	development
T11029	50391-50393	,	denotes	,
T11030	50393-50401	NN	denotes	function
T11031	50401-50403	,	denotes	,
T11032	50403-50406	CC	denotes	and
T11033	50407-50414	NN	denotes	disease
T11034	50426-50428	IN	denotes	of
T11035	50429-50435	NNS	denotes	joints
T11036	50435-50437	,	denotes	,
T11037	50437-50440	CC	denotes	and
T11038	50441-50444	MD	denotes	may
T11039	50445-50450	VB	denotes	bring
T11040	50451-50453	PRP	denotes	us
T11041	50454-50460	JJR	denotes	closer
T11042	50461-50463	IN	denotes	to
T11043	50464-50470	JJR	denotes	better
T11044	50471-50481	NN	denotes	prevention
T11045	50482-50485	CC	denotes	and
T11046	50486-50495	NN	denotes	treatment
T11047	50496-50498	IN	denotes	of
T11048	50499-50504	NN	denotes	joint
T11049	50505-50513	NNS	denotes	diseases
T11050	50513-50514	.	denotes	.
T11313	50539-50549	NN	denotes	Generation
T11314	50550-50552	IN	denotes	of
T11315	50553-50557	NN	denotes	Gdf5
T11316	50558-50561	NN	denotes	Cre
T11317	50557-50558	HYPH	denotes	-
T11318	50562-50572	JJ	denotes	transgenic
T11319	50573-50577	NNS	denotes	mice
T11320	50577-50679	sentence	denotes	A mouse 129x1/SvJ BAC library (Invitrogen) was screened to identify a 140-kb BAC from the Gdf5 locus.
T11321	50578-50579	DT	denotes	A
T11322	50600-50607	NN	denotes	library
T11323	50580-50585	NN	denotes	mouse
T11324	50596-50599	NN	denotes	BAC
T11325	50586-50591	NN	denotes	129x1
T11326	50592-50595	NN	denotes	SvJ
T11327	50591-50592	HYPH	denotes	/
T11328	50625-50633	VBN	denotes	screened
T11329	50608-50609	-LRB-	denotes	(
T11330	50609-50619	NNP	denotes	Invitrogen
T11331	50619-50620	-RRB-	denotes	)
T11332	50621-50624	VBD	denotes	was
T11333	50634-50636	TO	denotes	to
T11334	50637-50645	VB	denotes	identify
T11335	50646-50647	DT	denotes	a
T11336	50655-50658	NN	denotes	BAC
T11337	50648-50651	CD	denotes	140
T11338	50652-50654	NN	denotes	kb
T11339	50651-50652	HYPH	denotes	-
T11340	50659-50663	IN	denotes	from
T11341	50664-50667	DT	denotes	the
T11342	50673-50678	NN	denotes	locus
T11343	50668-50672	NN	denotes	Gdf5
T11344	50678-50679	.	denotes	.
T11345	50679-50966	sentence	denotes	This BAC was modified using a homologous recombination system in E. coli (Yang et al. 1997) to place nuclear-localized Cre recombinase (from plasmid pML78, gift of Gail Martin) followed by IRES-hPLAP (from plasmid 1726, gift of Oliver Bogler) directly behind the ATG start site of Gdf5.
T11346	50680-50684	DT	denotes	This
T11347	50685-50688	NN	denotes	BAC
T11348	50693-50701	VBN	denotes	modified
T11349	50689-50692	VBD	denotes	was
T11350	50702-50707	VBG	denotes	using
T11351	50708-50709	DT	denotes	a
T11352	50735-50741	NN	denotes	system
T11353	50710-50720	JJ	denotes	homologous
T11354	50721-50734	NN	denotes	recombination
T11355	50742-50744	IN	denotes	in
T11356	50745-50747	NNP	denotes	E.
T11357	50748-50752	NNP	denotes	coli
T11358	50753-50754	-LRB-	denotes	(
T11359	50754-50758	NNP	denotes	Yang
T11360	50759-50761	FW	denotes	et
T11361	50762-50765	FW	denotes	al.
T11362	50766-50770	CD	denotes	1997
T11363	50770-50771	-RRB-	denotes	)
T11364	50772-50774	TO	denotes	to
T11365	50775-50780	VB	denotes	place
T11366	50781-50788	JJ	denotes	nuclear
T11367	50789-50798	VBN	denotes	localized
T11368	50788-50789	HYPH	denotes	-
T11369	50803-50814	NN	denotes	recombinase
T11370	50799-50802	NN	denotes	Cre
T11371	50815-50816	-LRB-	denotes	(
T11372	50816-50820	IN	denotes	from
T11373	50821-50828	NN	denotes	plasmid
T11374	50829-50834	NN	denotes	pML78
T11375	50834-50836	,	denotes	,
T11376	50836-50840	NN	denotes	gift
T11377	50841-50843	IN	denotes	of
T11378	50844-50848	NNP	denotes	Gail
T11379	50849-50855	NNP	denotes	Martin
T11380	50855-50856	-RRB-	denotes	)
T11381	50857-50865	VBN	denotes	followed
T11382	50866-50868	IN	denotes	by
T11383	50869-50873	NN	denotes	IRES
T11384	50874-50879	NN	denotes	hPLAP
T11385	50873-50874	HYPH	denotes	-
T11386	50880-50881	-LRB-	denotes	(
T11387	50881-50885	IN	denotes	from
T11388	50886-50893	NN	denotes	plasmid
T11389	50894-50898	CD	denotes	1726
T11390	50898-50900	,	denotes	,
T11391	50900-50904	NN	denotes	gift
T11392	50905-50907	IN	denotes	of
T11393	50908-50914	NNP	denotes	Oliver
T11394	50915-50921	NNP	denotes	Bogler
T11395	50921-50922	-RRB-	denotes	)
T11396	50923-50931	RB	denotes	directly
T11397	50932-50938	IN	denotes	behind
T11398	50939-50942	DT	denotes	the
T11399	50953-50957	NN	denotes	site
T11400	50943-50946	NN	denotes	ATG
T11401	50947-50952	NN	denotes	start
T11402	50958-50960	IN	denotes	of
T11403	50961-50965	NN	denotes	Gdf5
T11404	50965-50966	.	denotes	.
T11405	50966-51087	sentence	denotes	In the process, 583 bp of the first exon of Gdf5 was removed and no functional GDF5 protein is predicted to be produced.
T11406	50967-50969	IN	denotes	In
T11407	51020-51027	VBN	denotes	removed
T11408	50970-50973	DT	denotes	the
T11409	50974-50981	NN	denotes	process
T11410	50981-50983	,	denotes	,
T11411	50983-50986	CD	denotes	583
T11412	50987-50989	NNS	denotes	bp
T11413	50990-50992	IN	denotes	of
T11414	50993-50996	DT	denotes	the
T11415	51003-51007	NN	denotes	exon
T11416	50997-51002	JJ	denotes	first
T11417	51008-51010	IN	denotes	of
T11418	51011-51015	NN	denotes	Gdf5
T11419	51016-51019	VBD	denotes	was
T11420	51028-51031	CC	denotes	and
T11421	51032-51034	DT	denotes	no
T11422	51051-51058	NN	denotes	protein
T11423	51035-51045	JJ	denotes	functional
T11424	51046-51050	NN	denotes	GDF5
T11425	51062-51071	VBN	denotes	predicted
T11426	51059-51061	VBZ	denotes	is
T11427	51072-51074	TO	denotes	to
T11428	51078-51086	VBN	denotes	produced
T11429	51075-51077	VB	denotes	be
T11430	51086-51087	.	denotes	.
T11431	51087-51379	sentence	denotes	The 5′ homology arm was subcloned from a PCR product tailed with XhoI and Bsp120I restriction sites that contains 781 bp of 5′ genomic Gdf5 sequence ending at the ATG translation start site (forward primer 5′-CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC-3′; reverse 5′-GTTTGGGCCCATCCTCTGGCCAGCCGCTG-3′).
T11432	51088-51091	DT	denotes	The
T11433	51104-51107	NN	denotes	arm
T11434	51092-51093	CD	denotes	5
T11435	51093-51094	SYM	denotes	′
T11436	51095-51103	NN	denotes	homology
T11437	51112-51121	VBN	denotes	subcloned
T11438	51108-51111	VBD	denotes	was
T11439	51122-51126	IN	denotes	from
T11440	51127-51128	DT	denotes	a
T11441	51133-51140	NN	denotes	product
T11442	51129-51132	NN	denotes	PCR
T11443	51141-51147	VBN	denotes	tailed
T11444	51148-51152	IN	denotes	with
T11445	51153-51157	NN	denotes	XhoI
T11446	51182-51187	NNS	denotes	sites
T11447	51158-51161	CC	denotes	and
T11448	51162-51169	NN	denotes	Bsp120I
T11449	51170-51181	NN	denotes	restriction
T11450	51188-51192	WDT	denotes	that
T11451	51193-51201	VBZ	denotes	contains
T11452	51202-51205	CD	denotes	781
T11453	51206-51208	NNS	denotes	bp
T11454	51209-51211	IN	denotes	of
T11455	51212-51213	CD	denotes	5
T11456	51228-51236	NN	denotes	sequence
T11457	51213-51214	SYM	denotes	′
T11458	51215-51222	JJ	denotes	genomic
T11459	51223-51227	NN	denotes	Gdf5
T11460	51237-51243	VBG	denotes	ending
T11461	51244-51246	IN	denotes	at
T11462	51247-51250	DT	denotes	the
T11463	51273-51277	NN	denotes	site
T11464	51251-51254	NN	denotes	ATG
T11465	51255-51266	NN	denotes	translation
T11466	51267-51272	NN	denotes	start
T11467	51278-51279	-LRB-	denotes	(
T11468	51345-51374	NN	denotes	GTTTGGGCCCATCCTCTGGCCAGCCGCTG
T11469	51279-51286	JJ	denotes	forward
T11470	51287-51293	NN	denotes	primer
T11471	51297-51329	NN	denotes	CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC
T11472	51294-51295	CD	denotes	5
T11473	51295-51296	SYM	denotes	′
T11474	51296-51297	HYPH	denotes	-
T11475	51329-51330	HYPH	denotes	-
T11476	51330-51331	CD	denotes	3
T11477	51331-51332	SYM	denotes	′
T11478	51332-51333	:	denotes	;
T11479	51334-51341	JJ	denotes	reverse
T11480	51342-51343	CD	denotes	5
T11481	51343-51344	SYM	denotes	′
T11482	51344-51345	HYPH	denotes	-
T11483	51374-51375	HYPH	denotes	-
T11484	51375-51376	CD	denotes	3
T11485	51376-51377	SYM	denotes	′
T11486	51377-51378	-RRB-	denotes	)
T11487	51378-51379	.	denotes	.
T11488	51379-51444	sentence	denotes	Cre was subcloned from a 1.1-kb Bsp120I/EcoRI fragment of pML78.
T11489	51380-51383	NN	denotes	Cre
T11490	51388-51397	VBN	denotes	subcloned
T11491	51384-51387	VBD	denotes	was
T11492	51398-51402	IN	denotes	from
T11493	51403-51404	DT	denotes	a
T11494	51426-51434	NN	denotes	fragment
T11495	51405-51408	CD	denotes	1.1
T11496	51409-51411	NN	denotes	kb
T11497	51408-51409	HYPH	denotes	-
T11498	51412-51419	NN	denotes	Bsp120I
T11499	51420-51425	NN	denotes	EcoRI
T11500	51419-51420	HYPH	denotes	/
T11501	51435-51437	IN	denotes	of
T11502	51438-51443	NN	denotes	pML78
T11503	51443-51444	.	denotes	.
T11504	51444-51691	sentence	denotes	IRES hPLAP was subcloned from a 2.1-kb PCR product tailed with EcoRI and SpeI sites that contains the hPLAP translation stop site (forward primer 5′-ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG-3′; reverse 5′-AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG-3′).
T11505	51445-51449	NN	denotes	IRES
T11506	51450-51455	NN	denotes	hPLAP
T11507	51460-51469	VBN	denotes	subcloned
T11508	51456-51459	VBD	denotes	was
T11509	51470-51474	IN	denotes	from
T11510	51475-51476	DT	denotes	a
T11511	51488-51495	NN	denotes	product
T11512	51477-51480	CD	denotes	2.1
T11513	51481-51483	NN	denotes	kb
T11514	51480-51481	HYPH	denotes	-
T11515	51484-51487	NN	denotes	PCR
T11516	51496-51502	VBN	denotes	tailed
T11517	51503-51507	IN	denotes	with
T11518	51508-51513	NN	denotes	EcoRI
T11519	51523-51528	NNS	denotes	sites
T11520	51514-51517	CC	denotes	and
T11521	51518-51522	NN	denotes	SpeI
T11522	51529-51533	WDT	denotes	that
T11523	51534-51542	VBZ	denotes	contains
T11524	51543-51546	DT	denotes	the
T11525	51570-51574	NN	denotes	site
T11526	51547-51552	NN	denotes	hPLAP
T11527	51553-51564	NN	denotes	translation
T11528	51565-51569	NN	denotes	stop
T11529	51575-51576	-LRB-	denotes	(
T11530	51648-51686	NN	denotes	AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
T11531	51576-51583	JJ	denotes	forward
T11532	51584-51590	NN	denotes	primer
T11533	51594-51632	NN	denotes	ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG
T11534	51591-51592	CD	denotes	5
T11535	51592-51593	SYM	denotes	′
T11536	51593-51594	HYPH	denotes	-
T11537	51632-51633	HYPH	denotes	-
T11538	51633-51634	CD	denotes	3
T11539	51634-51635	SYM	denotes	′
T11540	51635-51636	:	denotes	;
T11541	51637-51644	JJ	denotes	reverse
T11542	51645-51646	CD	denotes	5
T11543	51646-51647	SYM	denotes	′
T11544	51647-51648	HYPH	denotes	-
T11545	51686-51687	HYPH	denotes	-
T11546	51687-51688	CD	denotes	3
T11547	51688-51689	SYM	denotes	′
T11548	51689-51690	-RRB-	denotes	)
T11549	51690-51691	.	denotes	.
T11550	51691-51859	sentence	denotes	The 3′ homology arm was subcloned from a 0.8-kb PCR product amplified from a 0.9-kb XhoI Gdf5 genomic subclone containing part of the first exon and downstream intron.
T11551	51692-51695	DT	denotes	The
T11552	51708-51711	NN	denotes	arm
T11553	51696-51697	CD	denotes	3
T11554	51697-51698	SYM	denotes	′
T11555	51699-51707	NN	denotes	homology
T11556	51716-51725	VBN	denotes	subcloned
T11557	51712-51715	VBD	denotes	was
T11558	51726-51730	IN	denotes	from
T11559	51731-51732	DT	denotes	a
T11560	51744-51751	NN	denotes	product
T11561	51733-51736	CD	denotes	0.8
T11562	51737-51739	NN	denotes	kb
T11563	51736-51737	HYPH	denotes	-
T11564	51740-51743	NN	denotes	PCR
T11565	51752-51761	VBN	denotes	amplified
T11566	51762-51766	IN	denotes	from
T11567	51767-51768	DT	denotes	a
T11568	51794-51802	NN	denotes	subclone
T11569	51769-51772	CD	denotes	0.9
T11570	51773-51775	NN	denotes	kb
T11571	51772-51773	HYPH	denotes	-
T11572	51776-51780	NN	denotes	XhoI
T11573	51781-51785	NN	denotes	Gdf5
T11574	51786-51793	JJ	denotes	genomic
T11575	51803-51813	VBG	denotes	containing
T11576	51814-51818	NN	denotes	part
T11577	51819-51821	IN	denotes	of
T11578	51822-51825	DT	denotes	the
T11579	51832-51836	NN	denotes	exon
T11580	51826-51831	JJ	denotes	first
T11581	51837-51840	CC	denotes	and
T11582	51841-51851	JJ	denotes	downstream
T11583	51852-51858	NN	denotes	intron
T11584	51858-51859	.	denotes	.
T11585	51859-52174	sentence	denotes	The forward primer contains the 3′ end of the first exon and is tailed with a SpeI site; the reverse primer is from the T7 promoter of the vector containing the 0.9-kb subclone and flanks the intronic XhoI site (forward primer 5′-CTAAACTAGTCACCAGCTTTATTGACAAAGG-3′; reverse 5′-GATTTCTAGAGTAATACGACTCACTATAGGGC-3′).
T11586	51860-51863	DT	denotes	The
T11587	51872-51878	NN	denotes	primer
T11588	51864-51871	JJ	denotes	forward
T11589	51879-51887	VBZ	denotes	contains
T11590	51968-51970	VBZ	denotes	is
T11591	51888-51891	DT	denotes	the
T11592	51895-51898	NN	denotes	end
T11593	51892-51893	CD	denotes	3
T11594	51893-51894	SYM	denotes	′
T11595	51899-51901	IN	denotes	of
T11596	51902-51905	DT	denotes	the
T11597	51912-51916	NN	denotes	exon
T11598	51906-51911	JJ	denotes	first
T11599	51917-51920	CC	denotes	and
T11600	51921-51923	VBZ	denotes	is
T11601	51924-51930	VBN	denotes	tailed
T11602	51931-51935	IN	denotes	with
T11603	51936-51937	DT	denotes	a
T11604	51943-51947	NN	denotes	site
T11605	51938-51942	NN	denotes	SpeI
T11606	51947-51948	:	denotes	;
T11607	51949-51952	DT	denotes	the
T11608	51961-51967	NN	denotes	primer
T11609	51953-51960	JJ	denotes	reverse
T11610	51971-51975	IN	denotes	from
T11611	51976-51979	DT	denotes	the
T11612	51983-51991	NN	denotes	promoter
T11613	51980-51982	NN	denotes	T7
T11614	51992-51994	IN	denotes	of
T11615	51995-51998	DT	denotes	the
T11616	51999-52005	NN	denotes	vector
T11617	52006-52016	VBG	denotes	containing
T11618	52017-52020	DT	denotes	the
T11619	52028-52036	NN	denotes	subclone
T11620	52021-52024	CD	denotes	0.9
T11621	52025-52027	NN	denotes	kb
T11622	52024-52025	HYPH	denotes	-
T11623	52037-52040	CC	denotes	and
T11624	52041-52047	VBZ	denotes	flanks
T11625	52048-52051	DT	denotes	the
T11626	52066-52070	NN	denotes	site
T11627	52052-52060	JJ	denotes	intronic
T11628	52061-52065	NN	denotes	XhoI
T11629	52071-52072	-LRB-	denotes	(
T11630	52137-52169	NN	denotes	GATTTCTAGAGTAATACGACTCACTATAGGGC
T11631	52072-52079	JJ	denotes	forward
T11632	52080-52086	NN	denotes	primer
T11633	52090-52121	NN	denotes	CTAAACTAGTCACCAGCTTTATTGACAAAGG
T11634	52087-52088	CD	denotes	5
T11635	52088-52089	SYM	denotes	′
T11636	52089-52090	HYPH	denotes	-
T11637	52121-52122	HYPH	denotes	-
T11638	52122-52123	CD	denotes	3
T11639	52123-52124	SYM	denotes	′
T11640	52124-52125	:	denotes	;
T11641	52126-52133	JJ	denotes	reverse
T11642	52134-52135	CD	denotes	5
T11643	52135-52136	SYM	denotes	′
T11644	52136-52137	HYPH	denotes	-
T11645	52169-52170	HYPH	denotes	-
T11646	52170-52171	CD	denotes	3
T11647	52171-52172	SYM	denotes	′
T11648	52172-52173	-RRB-	denotes	)
T11649	52173-52174	.	denotes	.
T11650	52174-52395	sentence	denotes	The targeting construct was built and verified in pBSSK (Stratagene, La Jolla, California, United States), then digested with XhoI and subcloned into pSV1, the vector used for homologous recombination (Yang et al. 1997).
T11651	52175-52178	DT	denotes	The
T11652	52189-52198	NN	denotes	construct
T11653	52179-52188	NN	denotes	targeting
T11654	52203-52208	VBN	denotes	built
T11655	52199-52202	VBD	denotes	was
T11656	52209-52212	CC	denotes	and
T11657	52213-52221	VBN	denotes	verified
T11658	52222-52224	IN	denotes	in
T11659	52225-52230	NN	denotes	pBSSK
T11660	52231-52232	-LRB-	denotes	(
T11661	52232-52242	NNP	denotes	Stratagene
T11662	52242-52244	,	denotes	,
T11663	52244-52246	NNP	denotes	La
T11664	52247-52252	NNP	denotes	Jolla
T11665	52252-52254	,	denotes	,
T11666	52254-52264	NNP	denotes	California
T11667	52264-52266	,	denotes	,
T11668	52266-52272	NNP	denotes	United
T11669	52273-52279	NNP	denotes	States
T11670	52279-52280	-RRB-	denotes	)
T11671	52280-52282	,	denotes	,
T11672	52282-52286	RB	denotes	then
T11673	52287-52295	VBN	denotes	digested
T11674	52296-52300	IN	denotes	with
T11675	52301-52305	NN	denotes	XhoI
T11676	52306-52309	CC	denotes	and
T11677	52310-52319	VBN	denotes	subcloned
T11678	52320-52324	IN	denotes	into
T11679	52325-52329	NN	denotes	pSV1
T11680	52329-52331	,	denotes	,
T11681	52331-52334	DT	denotes	the
T11682	52335-52341	NN	denotes	vector
T11683	52342-52346	VBN	denotes	used
T11684	52347-52350	IN	denotes	for
T11685	52351-52361	JJ	denotes	homologous
T11686	52362-52375	NN	denotes	recombination
T11687	52376-52377	-LRB-	denotes	(
T11688	52377-52381	NNP	denotes	Yang
T11689	52382-52384	FW	denotes	et
T11690	52385-52388	FW	denotes	al.
T11691	52389-52393	CD	denotes	1997
T11692	52393-52394	-RRB-	denotes	)
T11693	52394-52395	.	denotes	.
T11694	52395-52543	sentence	denotes	Southern blotting, PCR, and DNA sequence analysis confirmed the appropriate targeting construct and BAC modifications were made (unpublished data).
T11695	52396-52404	NNP	denotes	Southern
T11696	52405-52413	NN	denotes	blotting
T11697	52437-52445	NN	denotes	analysis
T11698	52413-52415	,	denotes	,
T11699	52415-52418	NN	denotes	PCR
T11700	52418-52420	,	denotes	,
T11701	52420-52423	CC	denotes	and
T11702	52424-52427	NN	denotes	DNA
T11703	52428-52436	NN	denotes	sequence
T11704	52446-52455	VBD	denotes	confirmed
T11705	52456-52459	DT	denotes	the
T11706	52482-52491	NN	denotes	construct
T11707	52460-52471	JJ	denotes	appropriate
T11708	52472-52481	NN	denotes	targeting
T11709	52519-52523	VBN	denotes	made
T11710	52492-52495	CC	denotes	and
T11711	52496-52499	NN	denotes	BAC
T11712	52500-52513	NNS	denotes	modifications
T11713	52514-52518	VBD	denotes	were
T11714	52524-52525	-LRB-	denotes	(
T11715	52537-52541	NNS	denotes	data
T11716	52525-52536	JJ	denotes	unpublished
T11717	52541-52542	-RRB-	denotes	)
T11718	52542-52543	.	denotes	.
T11719	52543-52745	sentence	denotes	Before the modified BAC was injected to produce transgenic animals, a loxP site present in the BAC vector, pBeloBAC11, was removed to prevent the addition of undesired Cre target sites into the genome.
T11720	52544-52550	IN	denotes	Before
T11721	52572-52580	VBN	denotes	injected
T11722	52551-52554	DT	denotes	the
T11723	52564-52567	NN	denotes	BAC
T11724	52555-52563	VBN	denotes	modified
T11725	52568-52571	VBD	denotes	was
T11726	52667-52674	VBN	denotes	removed
T11727	52581-52583	TO	denotes	to
T11728	52584-52591	VB	denotes	produce
T11729	52592-52602	JJ	denotes	transgenic
T11730	52603-52610	NNS	denotes	animals
T11731	52610-52612	,	denotes	,
T11732	52612-52613	DT	denotes	a
T11733	52619-52623	NN	denotes	site
T11734	52614-52618	NN	denotes	loxP
T11735	52624-52631	JJ	denotes	present
T11736	52632-52634	IN	denotes	in
T11737	52635-52638	DT	denotes	the
T11738	52643-52649	NN	denotes	vector
T11739	52639-52642	NN	denotes	BAC
T11740	52649-52651	,	denotes	,
T11741	52651-52661	NN	denotes	pBeloBAC11
T11742	52661-52663	,	denotes	,
T11743	52663-52666	VBD	denotes	was
T11744	52675-52677	TO	denotes	to
T11745	52678-52685	VB	denotes	prevent
T11746	52686-52689	DT	denotes	the
T11747	52690-52698	NN	denotes	addition
T11748	52699-52701	IN	denotes	of
T11749	52702-52711	JJ	denotes	undesired
T11750	52723-52728	NNS	denotes	sites
T11751	52712-52715	NN	denotes	Cre
T11752	52716-52722	NN	denotes	target
T11753	52729-52733	IN	denotes	into
T11754	52734-52737	DT	denotes	the
T11755	52738-52744	NN	denotes	genome
T11756	52744-52745	.	denotes	.
T11757	52745-52900	sentence	denotes	To do this, BAC DNA was prepared by CsCl separation, digested with NotI to free the insert from the vector, and size-fractionated over a sucrose gradient.
T11758	52746-52748	TO	denotes	To
T11759	52749-52751	VB	denotes	do
T11760	52770-52778	VBN	denotes	prepared
T11761	52752-52756	DT	denotes	this
T11762	52756-52758	,	denotes	,
T11763	52758-52761	NN	denotes	BAC
T11764	52762-52765	NN	denotes	DNA
T11765	52766-52769	VBD	denotes	was
T11766	52779-52781	IN	denotes	by
T11767	52782-52786	NN	denotes	CsCl
T11768	52787-52797	NN	denotes	separation
T11769	52797-52799	,	denotes	,
T11770	52799-52807	VBN	denotes	digested
T11771	52808-52812	IN	denotes	with
T11772	52813-52817	NN	denotes	NotI
T11773	52818-52820	TO	denotes	to
T11774	52821-52825	VB	denotes	free
T11775	52826-52829	DT	denotes	the
T11776	52830-52836	NN	denotes	insert
T11777	52837-52841	IN	denotes	from
T11778	52842-52845	DT	denotes	the
T11779	52846-52852	NN	denotes	vector
T11780	52852-52854	,	denotes	,
T11781	52854-52857	CC	denotes	and
T11782	52858-52862	NN	denotes	size
T11783	52863-52875	VBN	denotes	fractionated
T11784	52862-52863	HYPH	denotes	-
T11785	52876-52880	IN	denotes	over
T11786	52881-52882	DT	denotes	a
T11787	52891-52899	NN	denotes	gradient
T11788	52883-52890	NN	denotes	sucrose
T11789	52899-52900	.	denotes	.
T11790	52900-53011	sentence	denotes	Aliquots of fractions were run on a pulse-field gel and Southern blotted using vector-specific DNA as a probe.
T11791	52901-52909	NNS	denotes	Aliquots
T11792	52928-52931	VBN	denotes	run
T11793	52910-52912	IN	denotes	of
T11794	52913-52922	NNS	denotes	fractions
T11795	52923-52927	VBD	denotes	were
T11796	52932-52934	IN	denotes	on
T11797	52935-52936	DT	denotes	a
T11798	52949-52952	NN	denotes	gel
T11799	52937-52942	NN	denotes	pulse
T11800	52943-52948	NN	denotes	field
T11801	52942-52943	HYPH	denotes	-
T11802	52953-52956	CC	denotes	and
T11803	52957-52965	NNP	denotes	Southern
T11804	52966-52973	VBN	denotes	blotted
T11805	52974-52979	VBG	denotes	using
T11806	52980-52986	NN	denotes	vector
T11807	52996-52999	NN	denotes	DNA
T11808	52986-52987	HYPH	denotes	-
T11809	52987-52995	JJ	denotes	specific
T11810	53000-53002	IN	denotes	as
T11811	53003-53004	DT	denotes	a
T11812	53005-53010	NN	denotes	probe
T11813	53010-53011	.	denotes	.
T11814	53011-53261	sentence	denotes	Fractions containing unsheared insert and almost no detectable vector DNA were dialyzed in microinjection buffer (10 mM Tris [pH 7.4] with 0.15 mM EDTA [pH 8.0]) using Centriprep-30 concentrators (Millipore, Billerica, Massachusetts, United States).
T11815	53012-53021	NNS	denotes	Fractions
T11816	53091-53099	VBN	denotes	dialyzed
T11817	53022-53032	VBG	denotes	containing
T11818	53033-53042	JJ	denotes	unsheared
T11819	53043-53049	NN	denotes	insert
T11820	53050-53053	CC	denotes	and
T11821	53054-53060	RB	denotes	almost
T11822	53082-53085	NN	denotes	DNA
T11823	53061-53063	DT	denotes	no
T11824	53064-53074	JJ	denotes	detectable
T11825	53075-53081	NN	denotes	vector
T11826	53086-53090	VBD	denotes	were
T11827	53100-53102	IN	denotes	in
T11828	53103-53117	NN	denotes	microinjection
T11829	53118-53124	NN	denotes	buffer
T11830	53125-53126	-LRB-	denotes	(
T11831	53132-53136	NN	denotes	Tris
T11832	53126-53128	CD	denotes	10
T11833	53129-53131	NN	denotes	mM
T11834	53137-53138	-LRB-	denotes	[
T11835	53138-53140	NN	denotes	pH
T11836	53141-53144	CD	denotes	7.4
T11837	53144-53145	-RRB-	denotes	]
T11838	53146-53150	IN	denotes	with
T11839	53151-53155	CD	denotes	0.15
T11840	53156-53158	NN	denotes	mM
T11841	53159-53163	NN	denotes	EDTA
T11842	53164-53165	-LRB-	denotes	[
T11843	53165-53167	NN	denotes	pH
T11844	53168-53171	CD	denotes	8.0
T11845	53171-53172	-RRB-	denotes	]
T11846	53172-53173	-RRB-	denotes	)
T11847	53174-53179	VBG	denotes	using
T11848	53180-53190	NN	denotes	Centriprep
T11849	53194-53207	NNS	denotes	concentrators
T11850	53190-53191	HYPH	denotes	-
T11851	53191-53193	CD	denotes	30
T11852	53208-53209	-LRB-	denotes	(
T11853	53209-53218	NNP	denotes	Millipore
T11854	53218-53220	,	denotes	,
T11855	53220-53229	NNP	denotes	Billerica
T11856	53229-53231	,	denotes	,
T11857	53231-53244	NNP	denotes	Massachusetts
T11858	53244-53246	,	denotes	,
T11859	53246-53252	NNP	denotes	United
T11860	53253-53259	NNP	denotes	States
T11861	53259-53260	-RRB-	denotes	)
T11862	53260-53261	.	denotes	.
T11863	53261-53415	sentence	denotes	This purified insert DNA was adjusted to 1 ng/μl and injected into the pronucleus of fertilized eggs from FVB/N mice by the Stanford Transgenic Facility.
T11864	53262-53266	DT	denotes	This
T11865	53283-53286	NN	denotes	DNA
T11866	53267-53275	VBN	denotes	purified
T11867	53276-53282	NN	denotes	insert
T11868	53291-53299	VBN	denotes	adjusted
T11869	53287-53290	VBD	denotes	was
T11870	53300-53302	IN	denotes	to
T11871	53303-53304	CD	denotes	1
T11872	53305-53307	NN	denotes	ng
T11873	53307-53308	SYM	denotes	/
T11874	53308-53310	NN	denotes	μl
T11875	53311-53314	CC	denotes	and
T11876	53315-53323	VBN	denotes	injected
T11877	53324-53328	IN	denotes	into
T11878	53329-53332	DT	denotes	the
T11879	53333-53343	NN	denotes	pronucleus
T11880	53344-53346	IN	denotes	of
T11881	53347-53357	VBN	denotes	fertilized
T11882	53358-53362	NNS	denotes	eggs
T11883	53363-53367	IN	denotes	from
T11884	53368-53371	NN	denotes	FVB
T11885	53372-53373	NN	denotes	N
T11886	53371-53372	HYPH	denotes	/
T11887	53374-53378	NNS	denotes	mice
T11888	53379-53381	IN	denotes	by
T11889	53382-53385	DT	denotes	the
T11890	53406-53414	NNP	denotes	Facility
T11891	53386-53394	NNP	denotes	Stanford
T11892	53395-53405	NNP	denotes	Transgenic
T11893	53414-53415	.	denotes	.
T11894	53415-53764	sentence	denotes	Transgenic founder mice were identified by PCR using Cre-specific primers 5′-GCCTGCATTACCGGTCGATGCAACGA-3′ and 5′-GTGGCAGATGGCGCGGCAACACCATT-3′, which amplify a 725-bp product, and were assessed for absence of BAC vector using vector-specific primers 5′-CGGAGTCTGATGCGGTTGCGATG-3′ and 5′-AGTGCTGTTCCCTGGTGCTTCCTC-3′, which amplify a 465-bp product.
T11895	53416-53426	JJ	denotes	Transgenic
T11896	53435-53439	NNS	denotes	mice
T11897	53427-53434	NN	denotes	founder
T11898	53445-53455	VBN	denotes	identified
T11899	53440-53444	VBD	denotes	were
T11900	53456-53458	IN	denotes	by
T11901	53459-53462	NN	denotes	PCR
T11902	53463-53468	VBG	denotes	using
T11903	53469-53472	NN	denotes	Cre
T11904	53473-53481	JJ	denotes	specific
T11905	53472-53473	HYPH	denotes	-
T11906	53493-53519	NN	denotes	GCCTGCATTACCGGTCGATGCAACGA
T11907	53482-53489	NNS	denotes	primers
T11908	53490-53491	CD	denotes	5
T11909	53491-53492	SYM	denotes	′
T11910	53492-53493	HYPH	denotes	-
T11911	53519-53520	HYPH	denotes	-
T11912	53520-53521	CD	denotes	3
T11913	53521-53522	SYM	denotes	′
T11914	53523-53526	CC	denotes	and
T11915	53527-53528	CD	denotes	5
T11916	53530-53556	NN	denotes	GTGGCAGATGGCGCGGCAACACCATT
T11917	53528-53529	SYM	denotes	′
T11918	53529-53530	HYPH	denotes	-
T11919	53556-53557	HYPH	denotes	-
T11920	53557-53558	CD	denotes	3
T11921	53558-53559	SYM	denotes	′
T11922	53559-53561	,	denotes	,
T11923	53561-53566	WDT	denotes	which
T11924	53567-53574	VBP	denotes	amplify
T11925	53575-53576	DT	denotes	a
T11926	53584-53591	NN	denotes	product
T11927	53577-53580	CD	denotes	725
T11928	53581-53583	NN	denotes	bp
T11929	53580-53581	HYPH	denotes	-
T11930	53591-53593	,	denotes	,
T11931	53593-53596	CC	denotes	and
T11932	53597-53601	VBD	denotes	were
T11933	53602-53610	VBN	denotes	assessed
T11934	53611-53614	IN	denotes	for
T11935	53615-53622	NN	denotes	absence
T11936	53623-53625	IN	denotes	of
T11937	53626-53629	NN	denotes	BAC
T11938	53630-53636	NN	denotes	vector
T11939	53637-53642	VBG	denotes	using
T11940	53643-53649	NN	denotes	vector
T11941	53659-53666	NNS	denotes	primers
T11942	53649-53650	HYPH	denotes	-
T11943	53650-53658	JJ	denotes	specific
T11944	53667-53668	CD	denotes	5
T11945	53670-53693	NN	denotes	CGGAGTCTGATGCGGTTGCGATG
T11946	53668-53669	SYM	denotes	′
T11947	53669-53670	HYPH	denotes	-
T11948	53693-53694	HYPH	denotes	-
T11949	53694-53695	CD	denotes	3
T11950	53695-53696	SYM	denotes	′
T11951	53697-53700	CC	denotes	and
T11952	53701-53702	CD	denotes	5
T11953	53704-53728	NN	denotes	AGTGCTGTTCCCTGGTGCTTCCTC
T11954	53702-53703	SYM	denotes	′
T11955	53703-53704	HYPH	denotes	-
T11956	53728-53729	HYPH	denotes	-
T11957	53729-53730	CD	denotes	3
T11958	53730-53731	SYM	denotes	′
T11959	53731-53733	,	denotes	,
T11960	53733-53738	WDT	denotes	which
T11961	53739-53746	VBP	denotes	amplify
T11962	53747-53748	DT	denotes	a
T11963	53756-53763	NN	denotes	product
T11964	53749-53752	CD	denotes	465
T11965	53753-53755	NN	denotes	bp
T11966	53752-53753	HYPH	denotes	-
T11967	53763-53764	.	denotes	.
T11968	53764-53848	sentence	denotes	Three lines of Gdf5-Cre mice were established and maintained on the FVB background.
T11969	53765-53770	CD	denotes	Three
T11970	53771-53776	NNS	denotes	lines
T11971	53799-53810	VBN	denotes	established
T11972	53777-53779	IN	denotes	of
T11973	53780-53784	NN	denotes	Gdf5
T11974	53785-53788	NN	denotes	Cre
T11975	53784-53785	HYPH	denotes	-
T11976	53789-53793	NNS	denotes	mice
T11977	53794-53798	VBD	denotes	were
T11978	53811-53814	CC	denotes	and
T11979	53815-53825	VBN	denotes	maintained
T11980	53826-53828	IN	denotes	on
T11981	53829-53832	DT	denotes	the
T11982	53837-53847	NN	denotes	background
T11983	53833-53836	NN	denotes	FVB
T11984	53847-53848	.	denotes	.
T11985	53848-53950	sentence	denotes	Matings with R26R Cre-inducible LACZ reporter mice (Soriano 1999) were used to test for Cre activity.
T11986	53849-53856	NNS	denotes	Matings
T11987	53920-53924	VBN	denotes	used
T11988	53857-53861	IN	denotes	with
T11989	53862-53866	NN	denotes	R26R
T11990	53867-53870	NN	denotes	Cre
T11991	53871-53880	JJ	denotes	inducible
T11992	53870-53871	HYPH	denotes	-
T11993	53895-53899	NNS	denotes	mice
T11994	53881-53885	NN	denotes	LACZ
T11995	53886-53894	NN	denotes	reporter
T11996	53900-53901	-LRB-	denotes	(
T11997	53901-53908	NNP	denotes	Soriano
T11998	53909-53913	CD	denotes	1999
T11999	53913-53914	-RRB-	denotes	)
T12000	53915-53919	VBD	denotes	were
T12001	53925-53927	TO	denotes	to
T12002	53928-53932	VB	denotes	test
T12003	53933-53936	IN	denotes	for
T12004	53937-53940	NN	denotes	Cre
T12005	53941-53949	NN	denotes	activity
T12006	53949-53950	.	denotes	.
T12007	53950-54087	sentence	denotes	Staining for LACZ and HPLAP on whole embryos or sections of embryos was accomplished following established protocols (Lobe et al. 1999).
T12008	53951-53959	VBG	denotes	Staining
T12009	54023-54035	VBN	denotes	accomplished
T12010	53960-53963	IN	denotes	for
T12011	53964-53968	NN	denotes	LACZ
T12012	53969-53972	CC	denotes	and
T12013	53973-53978	NN	denotes	HPLAP
T12014	53979-53981	IN	denotes	on
T12015	53982-53987	JJ	denotes	whole
T12016	53988-53995	NNS	denotes	embryos
T12017	53996-53998	CC	denotes	or
T12018	53999-54007	NNS	denotes	sections
T12019	54008-54010	IN	denotes	of
T12020	54011-54018	NNS	denotes	embryos
T12021	54019-54022	VBD	denotes	was
T12022	54036-54045	VBG	denotes	following
T12023	54046-54057	VBN	denotes	established
T12024	54058-54067	NNS	denotes	protocols
T12025	54068-54069	-LRB-	denotes	(
T12026	54069-54073	NNP	denotes	Lobe
T12027	54074-54076	FW	denotes	et
T12028	54077-54080	FW	denotes	al.
T12029	54081-54085	CD	denotes	1999
T12030	54085-54086	-RRB-	denotes	)
T12031	54086-54087	.	denotes	.
T12032	54087-54236	sentence	denotes	The red LACZ substrate (see Figure 1E) is 6-chloro-3-indoxyl-beta-D-galactopyranoside (Biosynth International, Naperville, Illinois, United States).
T12033	54088-54091	DT	denotes	The
T12034	54101-54110	NN	denotes	substrate
T12035	54092-54095	JJ	denotes	red
T12036	54096-54100	NN	denotes	LACZ
T12037	54127-54129	VBZ	denotes	is
T12038	54111-54112	-LRB-	denotes	(
T12039	54112-54115	VB	denotes	see
T12040	54116-54122	NN	denotes	Figure
T12041	54123-54125	CD	denotes	1E
T12042	54125-54126	-RRB-	denotes	)
T12043	54130-54131	CD	denotes	6
T12044	54156-54173	NN	denotes	galactopyranoside
T12045	54131-54132	HYPH	denotes	-
T12046	54132-54138	NN	denotes	chloro
T12047	54138-54139	HYPH	denotes	-
T12048	54139-54140	CD	denotes	3
T12049	54140-54141	HYPH	denotes	-
T12050	54141-54148	NN	denotes	indoxyl
T12051	54148-54149	HYPH	denotes	-
T12052	54149-54153	NN	denotes	beta
T12053	54153-54154	HYPH	denotes	-
T12054	54154-54155	NN	denotes	D
T12055	54155-54156	HYPH	denotes	-
T12056	54174-54175	-LRB-	denotes	(
T12057	54184-54197	NNP	denotes	International
T12058	54175-54183	NNP	denotes	Biosynth
T12059	54197-54199	,	denotes	,
T12060	54199-54209	NNP	denotes	Naperville
T12061	54209-54211	,	denotes	,
T12062	54211-54219	NNP	denotes	Illinois
T12063	54219-54221	,	denotes	,
T12064	54221-54227	NNP	denotes	United
T12065	54228-54234	NNP	denotes	States
T12066	54234-54235	-RRB-	denotes	)
T12067	54235-54236	.	denotes	.
T12177	54238-54245	JJ	denotes	General
T12178	54246-54262	NN	denotes	characterization
T12179	54263-54265	IN	denotes	of
T12180	54266-54272	NN	denotes	Bmpr1a
T12181	54273-54279	JJ	denotes	mutant
T12182	54280-54284	NNS	denotes	mice
T12183	54284-54441	sentence	denotes	Bmpr1a null and floxed alleles (Ahn et al. 2001; Mishina et al. 2002) were obtained on a mixed 129 and C57BL/6 background and maintained by random breeding.
T12184	54285-54291	NN	denotes	Bmpr1a
T12185	54292-54296	JJ	denotes	null
T12186	54308-54315	NNS	denotes	alleles
T12187	54297-54300	CC	denotes	and
T12188	54301-54307	VBN	denotes	floxed
T12189	54360-54368	VBN	denotes	obtained
T12190	54316-54317	-LRB-	denotes	(
T12191	54317-54320	NNP	denotes	Ahn
T12192	54321-54323	FW	denotes	et
T12193	54324-54327	FW	denotes	al.
T12194	54328-54332	CD	denotes	2001
T12195	54332-54333	:	denotes	;
T12196	54334-54341	NNP	denotes	Mishina
T12197	54342-54344	FW	denotes	et
T12198	54345-54348	FW	denotes	al.
T12199	54349-54353	CD	denotes	2002
T12200	54353-54354	-RRB-	denotes	)
T12201	54355-54359	VBD	denotes	were
T12202	54369-54371	IN	denotes	on
T12203	54372-54373	DT	denotes	a
T12204	54396-54406	NN	denotes	background
T12205	54374-54379	VBN	denotes	mixed
T12206	54380-54383	CD	denotes	129
T12207	54384-54387	CC	denotes	and
T12208	54388-54393	NN	denotes	C57BL
T12209	54393-54394	HYPH	denotes	/
T12210	54394-54395	CD	denotes	6
T12211	54407-54410	CC	denotes	and
T12212	54411-54421	VBN	denotes	maintained
T12213	54422-54424	IN	denotes	by
T12214	54425-54431	JJ	denotes	random
T12215	54432-54440	NN	denotes	breeding
T12216	54440-54441	.	denotes	.
T12217	54441-54543	sentence	denotes	Mice carrying the null and floxed alleles were typically mated to Gdf5-Cre mice as shown in Figure 3.
T12218	54442-54446	NNS	denotes	Mice
T12219	54499-54504	VBN	denotes	mated
T12220	54447-54455	VBG	denotes	carrying
T12221	54456-54459	DT	denotes	the
T12222	54476-54483	NNS	denotes	alleles
T12223	54460-54464	JJ	denotes	null
T12224	54465-54468	CC	denotes	and
T12225	54469-54475	VBN	denotes	floxed
T12226	54484-54488	VBD	denotes	were
T12227	54489-54498	RB	denotes	typically
T12228	54505-54507	IN	denotes	to
T12229	54508-54512	NN	denotes	Gdf5
T12230	54513-54516	NN	denotes	Cre
T12231	54512-54513	HYPH	denotes	-
T12232	54517-54521	NNS	denotes	mice
T12233	54522-54524	IN	denotes	as
T12234	54525-54530	VBN	denotes	shown
T12235	54531-54533	IN	denotes	in
T12236	54534-54540	NN	denotes	Figure
T12237	54541-54542	CD	denotes	3
T12238	54542-54543	.	denotes	.
T12239	54543-54695	sentence	denotes	The resulting mice are on a mixed 129; C57Bl/6; FVB/N background, with both controls and mutant animals generated as littermates from the same matings.
T12240	54544-54547	DT	denotes	The
T12241	54558-54562	NNS	denotes	mice
T12242	54548-54557	VBG	denotes	resulting
T12243	54563-54566	VBP	denotes	are
T12244	54567-54569	IN	denotes	on
T12245	54570-54571	DT	denotes	a
T12246	54598-54608	NN	denotes	background
T12247	54572-54577	VBN	denotes	mixed
T12248	54578-54581	CD	denotes	129
T12249	54581-54582	:	denotes	;
T12250	54583-54588	NN	denotes	C57Bl
T12251	54588-54589	HYPH	denotes	/
T12252	54589-54590	CD	denotes	6
T12253	54590-54591	:	denotes	;
T12254	54592-54595	NN	denotes	FVB
T12255	54596-54597	NN	denotes	N
T12256	54595-54596	HYPH	denotes	/
T12257	54608-54610	,	denotes	,
T12258	54610-54614	IN	denotes	with
T12259	54648-54657	VBN	denotes	generated
T12260	54615-54619	CC	denotes	both
T12261	54620-54628	NNS	denotes	controls
T12262	54629-54632	CC	denotes	and
T12263	54633-54639	NN	denotes	mutant
T12264	54640-54647	NNS	denotes	animals
T12265	54658-54660	IN	denotes	as
T12266	54661-54672	NNS	denotes	littermates
T12267	54673-54677	IN	denotes	from
T12268	54678-54681	DT	denotes	the
T12269	54687-54694	NNS	denotes	matings
T12270	54682-54686	JJ	denotes	same
T12271	54694-54695	.	denotes	.
T12272	54695-54787	sentence	denotes	Whole-mount skeletal preparations were made from 34- to 36-d-old mice (Lufkin et al. 1992).
T12273	54696-54701	JJ	denotes	Whole
T12274	54702-54707	NN	denotes	mount
T12275	54701-54702	HYPH	denotes	-
T12276	54717-54729	NNS	denotes	preparations
T12277	54708-54716	JJ	denotes	skeletal
T12278	54735-54739	VBN	denotes	made
T12279	54730-54734	VBD	denotes	were
T12280	54740-54744	IN	denotes	from
T12281	54745-54747	CD	denotes	34
T12282	54752-54754	CD	denotes	36
T12283	54747-54748	HYPH	denotes	-
T12284	54749-54751	IN	denotes	to
T12285	54755-54756	NN	denotes	d
T12286	54754-54755	HYPH	denotes	-
T12287	54757-54760	JJ	denotes	old
T12288	54756-54757	HYPH	denotes	-
T12289	54761-54765	NNS	denotes	mice
T12290	54766-54767	-LRB-	denotes	(
T12291	54767-54773	NNP	denotes	Lufkin
T12292	54774-54776	FW	denotes	et
T12293	54777-54780	FW	denotes	al.
T12294	54781-54785	CD	denotes	1992
T12295	54785-54786	-RRB-	denotes	)
T12296	54786-54787	.	denotes	.
T12297	54787-55011	sentence	denotes	Pairs of ears from euthanized 6-mo-old animals were removed, pinned, photographed, projected, and measured from the base of the curve formed between the tragus and antitragus to the farthest point at the edge of the pinnae.
T12298	54788-54793	NNS	denotes	Pairs
T12299	54840-54847	VBN	denotes	removed
T12300	54794-54796	IN	denotes	of
T12301	54797-54801	NNS	denotes	ears
T12302	54802-54806	IN	denotes	from
T12303	54807-54817	VBN	denotes	euthanized
T12304	54827-54834	NNS	denotes	animals
T12305	54818-54819	CD	denotes	6
T12306	54820-54822	NN	denotes	mo
T12307	54819-54820	HYPH	denotes	-
T12308	54823-54826	JJ	denotes	old
T12309	54822-54823	HYPH	denotes	-
T12310	54835-54839	VBD	denotes	were
T12311	54847-54849	,	denotes	,
T12312	54849-54855	VBN	denotes	pinned
T12313	54855-54857	,	denotes	,
T12314	54857-54869	VBN	denotes	photographed
T12315	54869-54871	,	denotes	,
T12316	54871-54880	VBN	denotes	projected
T12317	54880-54882	,	denotes	,
T12318	54882-54885	CC	denotes	and
T12319	54886-54894	VBN	denotes	measured
T12320	54895-54899	IN	denotes	from
T12321	54900-54903	DT	denotes	the
T12322	54904-54908	NN	denotes	base
T12323	54909-54911	IN	denotes	of
T12324	54912-54915	DT	denotes	the
T12325	54916-54921	NN	denotes	curve
T12326	54922-54928	VBN	denotes	formed
T12327	54929-54936	IN	denotes	between
T12328	54937-54940	DT	denotes	the
T12329	54941-54947	NN	denotes	tragus
T12330	54948-54951	CC	denotes	and
T12331	54952-54962	NN	denotes	antitragus
T12332	54963-54965	IN	denotes	to
T12333	54966-54969	DT	denotes	the
T12334	54979-54984	NN	denotes	point
T12335	54970-54978	JJS	denotes	farthest
T12336	54985-54987	IN	denotes	at
T12337	54988-54991	DT	denotes	the
T12338	54992-54996	NN	denotes	edge
T12339	54997-54999	IN	denotes	of
T12340	55000-55003	DT	denotes	the
T12341	55004-55010	NNS	denotes	pinnae
T12342	55010-55011	.	denotes	.
T12343	55011-55190	sentence	denotes	Grasping ability in 6-mo-old mice was measured by placing animals on a slender rod and timing how long they could remain suspended on the rod, to a maximum time allowed of 2 min.
T12344	55012-55020	NN	denotes	Grasping
T12345	55021-55028	NN	denotes	ability
T12346	55050-55058	VBN	denotes	measured
T12347	55029-55031	IN	denotes	in
T12348	55032-55033	CD	denotes	6
T12349	55034-55036	NN	denotes	mo
T12350	55033-55034	HYPH	denotes	-
T12351	55037-55040	JJ	denotes	old
T12352	55036-55037	HYPH	denotes	-
T12353	55041-55045	NNS	denotes	mice
T12354	55046-55049	VBD	denotes	was
T12355	55059-55061	IN	denotes	by
T12356	55062-55069	VBG	denotes	placing
T12357	55070-55077	NNS	denotes	animals
T12358	55078-55080	IN	denotes	on
T12359	55081-55082	DT	denotes	a
T12360	55091-55094	NN	denotes	rod
T12361	55083-55090	JJ	denotes	slender
T12362	55095-55098	CC	denotes	and
T12363	55099-55105	VBG	denotes	timing
T12364	55106-55109	WRB	denotes	how
T12365	55110-55114	RB	denotes	long
T12366	55126-55132	VB	denotes	remain
T12367	55115-55119	PRP	denotes	they
T12368	55120-55125	MD	denotes	could
T12369	55133-55142	JJ	denotes	suspended
T12370	55143-55145	IN	denotes	on
T12371	55146-55149	DT	denotes	the
T12372	55150-55153	NN	denotes	rod
T12373	55153-55155	,	denotes	,
T12374	55155-55157	IN	denotes	to
T12375	55158-55159	DT	denotes	a
T12376	55168-55172	NN	denotes	time
T12377	55160-55167	JJ	denotes	maximum
T12378	55173-55180	VBN	denotes	allowed
T12379	55181-55183	IN	denotes	of
T12380	55184-55185	CD	denotes	2
T12381	55186-55189	NN	denotes	min
T12382	55189-55190	.	denotes	.
T12383	55190-55254	sentence	denotes	Data from five consecutive trials for each mouse were averaged.
T12384	55191-55195	NNS	denotes	Data
T12385	55245-55253	VBN	denotes	averaged
T12386	55196-55200	IN	denotes	from
T12387	55201-55205	CD	denotes	five
T12388	55218-55224	NNS	denotes	trials
T12389	55206-55217	JJ	denotes	consecutive
T12390	55225-55228	IN	denotes	for
T12391	55229-55233	DT	denotes	each
T12392	55234-55239	NN	denotes	mouse
T12393	55240-55244	VBD	denotes	were
T12394	55253-55254	.	denotes	.
T12395	55254-55386	sentence	denotes	Range of motion assays were conducted on the MT/P1 and P1/P2 joints of the second hindlimb digit from euthanized 18-wk-old animals.
T12396	55255-55260	NN	denotes	Range
T12397	55271-55277	NNS	denotes	assays
T12398	55261-55263	IN	denotes	of
T12399	55264-55270	NN	denotes	motion
T12400	55283-55292	VBN	denotes	conducted
T12401	55278-55282	VBD	denotes	were
T12402	55293-55295	IN	denotes	on
T12403	55296-55299	DT	denotes	the
T12404	55316-55322	NNS	denotes	joints
T12405	55300-55302	NN	denotes	MT
T12406	55303-55305	NN	denotes	P1
T12407	55302-55303	HYPH	denotes	/
T12408	55306-55309	CC	denotes	and
T12409	55310-55312	NN	denotes	P1
T12410	55313-55315	NN	denotes	P2
T12411	55312-55313	HYPH	denotes	/
T12412	55323-55325	IN	denotes	of
T12413	55326-55329	DT	denotes	the
T12414	55346-55351	NN	denotes	digit
T12415	55330-55336	JJ	denotes	second
T12416	55337-55345	NN	denotes	hindlimb
T12417	55352-55356	IN	denotes	from
T12418	55357-55367	VBN	denotes	euthanized
T12419	55378-55385	NNS	denotes	animals
T12420	55368-55370	CD	denotes	18
T12421	55371-55373	NN	denotes	wk
T12422	55370-55371	HYPH	denotes	-
T12423	55374-55377	JJ	denotes	old
T12424	55373-55374	HYPH	denotes	-
T12425	55385-55386	.	denotes	.
T12426	55386-55561	sentence	denotes	Forceps were used to bend the joint to its natural stopping position, and the resulting angle was measured to the nearest 10° under 12.5× magnification using a 360° reticule.
T12427	55387-55394	NNS	denotes	Forceps
T12428	55400-55404	VBN	denotes	used
T12429	55395-55399	VBD	denotes	were
T12430	55405-55407	TO	denotes	to
T12431	55408-55412	VB	denotes	bend
T12432	55413-55416	DT	denotes	the
T12433	55417-55422	NN	denotes	joint
T12434	55423-55425	IN	denotes	to
T12435	55426-55429	PRP$	denotes	its
T12436	55447-55455	NN	denotes	position
T12437	55430-55437	JJ	denotes	natural
T12438	55438-55446	NN	denotes	stopping
T12439	55455-55457	,	denotes	,
T12440	55457-55460	CC	denotes	and
T12441	55461-55464	DT	denotes	the
T12442	55475-55480	NN	denotes	angle
T12443	55465-55474	VBG	denotes	resulting
T12444	55485-55493	VBN	denotes	measured
T12445	55481-55484	VBD	denotes	was
T12446	55494-55496	IN	denotes	to
T12447	55497-55500	DT	denotes	the
T12448	55511-55512	NNS	denotes	°
T12449	55501-55508	JJS	denotes	nearest
T12450	55509-55511	CD	denotes	10
T12451	55513-55518	IN	denotes	under
T12452	55519-55523	CD	denotes	12.5
T12453	55525-55538	NN	denotes	magnification
T12454	55523-55524	SYM	denotes	×
T12455	55539-55544	VBG	denotes	using
T12456	55545-55546	DT	denotes	a
T12457	55552-55560	NN	denotes	reticule
T12458	55547-55550	CD	denotes	360
T12459	55550-55551	NN	denotes	°
T12460	55560-55561	.	denotes	.
T12461	55561-55630	sentence	denotes	Analysis described in this section occurred on animals lacking R26R.
T12462	55562-55570	NN	denotes	Analysis
T12463	55597-55605	VBD	denotes	occurred
T12464	55571-55580	VBN	denotes	described
T12465	55581-55583	IN	denotes	in
T12466	55584-55588	DT	denotes	this
T12467	55589-55596	NN	denotes	section
T12468	55606-55608	IN	denotes	on
T12469	55609-55616	NNS	denotes	animals
T12470	55617-55624	VBG	denotes	lacking
T12471	55625-55629	NN	denotes	R26R
T12472	55629-55630	.	denotes	.
T12473	55630-55809	sentence	denotes	Control mice included all nonmutant genotypes generated by Parent 1 being heterozygous for Gdf5-Cre and Bmpr1anull and Parent 2 being heterozygous for Bmpr1afloxP (see Figure 3).
T12474	55631-55638	NN	denotes	Control
T12475	55639-55643	NNS	denotes	mice
T12476	55644-55652	VBD	denotes	included
T12477	55653-55656	DT	denotes	all
T12478	55667-55676	NNS	denotes	genotypes
T12479	55657-55666	JJ	denotes	nonmutant
T12480	55677-55686	VBN	denotes	generated
T12481	55687-55689	IN	denotes	by
T12482	55690-55696	NN	denotes	Parent
T12483	55699-55704	VBG	denotes	being
T12484	55697-55698	CD	denotes	1
T12485	55705-55717	JJ	denotes	heterozygous
T12486	55718-55721	IN	denotes	for
T12487	55722-55726	NN	denotes	Gdf5
T12488	55727-55730	NN	denotes	Cre
T12489	55726-55727	HYPH	denotes	-
T12490	55731-55734	CC	denotes	and
T12491	55735-55745	NN	denotes	Bmpr1anull
T12492	55746-55749	CC	denotes	and
T12493	55750-55756	NN	denotes	Parent
T12494	55759-55764	VBG	denotes	being
T12495	55757-55758	CD	denotes	2
T12496	55765-55777	JJ	denotes	heterozygous
T12497	55778-55781	IN	denotes	for
T12498	55782-55793	NN	denotes	Bmpr1afloxP
T12499	55794-55795	-LRB-	denotes	(
T12500	55795-55798	VB	denotes	see
T12501	55799-55805	NN	denotes	Figure
T12502	55806-55807	CD	denotes	3
T12503	55807-55808	-RRB-	denotes	)
T12504	55808-55809	.	denotes	.
T12505	55809-55936	sentence	denotes	All statistical analysis used the Student's t-test or Welch's t-test, and values listed are mean ± standard error of the mean.
T12506	55810-55813	DT	denotes	All
T12507	55826-55834	NN	denotes	analysis
T12508	55814-55825	JJ	denotes	statistical
T12509	55835-55839	VBD	denotes	used
T12510	55840-55843	DT	denotes	the
T12511	55844-55851	NNP	denotes	Student
T12512	55856-55860	NN	denotes	test
T12513	55851-55853	POS	denotes	's
T12514	55854-55855	NN	denotes	t
T12515	55855-55856	HYPH	denotes	-
T12516	55861-55863	CC	denotes	or
T12517	55864-55869	NNP	denotes	Welch
T12518	55874-55878	NN	denotes	test
T12519	55869-55871	POS	denotes	's
T12520	55872-55873	NN	denotes	t
T12521	55873-55874	HYPH	denotes	-
T12522	55878-55880	,	denotes	,
T12523	55880-55883	CC	denotes	and
T12524	55884-55890	NNS	denotes	values
T12525	55898-55901	VBP	denotes	are
T12526	55891-55897	VBN	denotes	listed
T12527	55902-55906	JJ	denotes	mean
T12528	55907-55908	SYM	denotes	±
T12529	55909-55917	JJ	denotes	standard
T12530	55918-55923	NN	denotes	error
T12531	55924-55926	IN	denotes	of
T12532	55927-55930	DT	denotes	the
T12533	55931-55935	NN	denotes	mean
T12534	55935-55936	.	denotes	.
T12726	56307-56308	NN	denotes	%
T12651	55938-55942	NN	denotes	Cell
T12652	55943-55948	NN	denotes	death
T12653	55949-55952	CC	denotes	and
T12654	55953-55966	NN	denotes	proliferation
T12655	55967-55973	NNS	denotes	assays
T12656	55973-56109	sentence	denotes	Limbs from mutant and control animals at E13.5 and E14.5 were dissected and frozen in OCT (Sakura Finetek,Torrence, CA, United States).
T12657	55974-55979	NNS	denotes	Limbs
T12658	56036-56045	VBN	denotes	dissected
T12659	55980-55984	IN	denotes	from
T12660	55985-55991	JJ	denotes	mutant
T12661	56004-56011	NNS	denotes	animals
T12662	55992-55995	CC	denotes	and
T12663	55996-56003	NN	denotes	control
T12664	56012-56014	IN	denotes	at
T12665	56015-56020	NN	denotes	E13.5
T12666	56021-56024	CC	denotes	and
T12667	56025-56030	NN	denotes	E14.5
T12668	56031-56035	VBD	denotes	were
T12669	56046-56049	CC	denotes	and
T12670	56050-56056	VBN	denotes	frozen
T12671	56057-56059	IN	denotes	in
T12672	56060-56063	NN	denotes	OCT
T12673	56064-56065	-LRB-	denotes	(
T12674	56072-56079	NNP	denotes	Finetek
T12675	56065-56071	NNP	denotes	Sakura
T12676	56079-56080	,	denotes	,
T12677	56080-56088	NNP	denotes	Torrence
T12678	56088-56090	,	denotes	,
T12679	56090-56092	NNP	denotes	CA
T12680	56092-56094	,	denotes	,
T12681	56094-56100	NNP	denotes	United
T12682	56101-56107	NNP	denotes	States
T12683	56107-56108	-RRB-	denotes	)
T12684	56108-56109	.	denotes	.
T12685	56109-56239	sentence	denotes	Cryosections of tissue were assayed by TUNEL using the In Situ Cell Death Detection Kit, Fluorescein (Roche, Basel, Switzerland).
T12686	56110-56122	NNS	denotes	Cryosections
T12687	56138-56145	VBN	denotes	assayed
T12688	56123-56125	IN	denotes	of
T12689	56126-56132	NN	denotes	tissue
T12690	56133-56137	VBD	denotes	were
T12691	56146-56148	IN	denotes	by
T12692	56149-56154	NN	denotes	TUNEL
T12693	56155-56160	VBG	denotes	using
T12694	56161-56164	DT	denotes	the
T12695	56194-56197	NN	denotes	Kit
T12696	56165-56167	FW	denotes	In
T12697	56168-56172	FW	denotes	Situ
T12698	56184-56193	NN	denotes	Detection
T12699	56173-56177	NN	denotes	Cell
T12700	56178-56183	NN	denotes	Death
T12701	56197-56199	,	denotes	,
T12702	56199-56210	NNP	denotes	Fluorescein
T12703	56211-56212	-LRB-	denotes	(
T12704	56212-56217	NNP	denotes	Roche
T12705	56217-56219	,	denotes	,
T12706	56219-56224	NNP	denotes	Basel
T12707	56224-56226	,	denotes	,
T12708	56226-56237	NNP	denotes	Switzerland
T12709	56237-56238	-RRB-	denotes	)
T12710	56238-56239	.	denotes	.
T12711	56239-56543	sentence	denotes	Following TUNEL, slides were washed in PBS, blocked with PBS + 0.05% Tween-20 + 5% goat serum, washed again, and incubated with a 1:200 dilution of a rabbit anti-phospho-histone-H3 antibody called Mitosis Marker (Upstate Biotechnology, Lake Placid, New York, United States) to identify cells in mitosis.
T12712	56240-56249	VBG	denotes	Following
T12713	56269-56275	VBN	denotes	washed
T12714	56250-56255	NN	denotes	TUNEL
T12715	56255-56257	,	denotes	,
T12716	56257-56263	NNS	denotes	slides
T12717	56264-56268	VBD	denotes	were
T12718	56276-56278	IN	denotes	in
T12719	56279-56282	NN	denotes	PBS
T12720	56282-56284	,	denotes	,
T12721	56284-56291	VBN	denotes	blocked
T12722	56292-56296	IN	denotes	with
T12723	56297-56300	NN	denotes	PBS
T12724	56301-56302	SYM	denotes	+
T12725	56303-56307	CD	denotes	0.05
T12727	56309-56314	NN	denotes	Tween
T12728	56314-56315	HYPH	denotes	-
T12729	56315-56317	CD	denotes	20
T12730	56318-56319	SYM	denotes	+
T12731	56320-56321	CD	denotes	5
T12732	56321-56322	NN	denotes	%
T12733	56328-56333	NN	denotes	serum
T12734	56323-56327	NN	denotes	goat
T12735	56333-56335	,	denotes	,
T12736	56335-56341	VBD	denotes	washed
T12737	56342-56347	RB	denotes	again
T12738	56347-56349	,	denotes	,
T12739	56349-56352	CC	denotes	and
T12740	56353-56362	VBN	denotes	incubated
T12741	56363-56367	IN	denotes	with
T12742	56368-56369	DT	denotes	a
T12743	56376-56384	NN	denotes	dilution
T12744	56370-56371	CD	denotes	1
T12745	56371-56372	SYM	denotes	:
T12746	56372-56375	CD	denotes	200
T12747	56385-56387	IN	denotes	of
T12748	56388-56389	DT	denotes	a
T12749	56421-56429	NN	denotes	antibody
T12750	56390-56396	NN	denotes	rabbit
T12751	56397-56417	JJ	denotes	anti-phospho-histone
T12752	56418-56420	NN	denotes	H3
T12753	56417-56418	HYPH	denotes	-
T12754	56430-56436	VBN	denotes	called
T12755	56437-56444	NN	denotes	Mitosis
T12756	56445-56451	NN	denotes	Marker
T12757	56452-56453	-LRB-	denotes	(
T12758	56461-56474	NNP	denotes	Biotechnology
T12759	56453-56460	NNP	denotes	Upstate
T12760	56474-56476	,	denotes	,
T12761	56476-56480	NNP	denotes	Lake
T12762	56481-56487	NNP	denotes	Placid
T12763	56487-56489	,	denotes	,
T12764	56489-56492	NNP	denotes	New
T12765	56493-56497	NNP	denotes	York
T12766	56497-56499	,	denotes	,
T12767	56499-56505	NNP	denotes	United
T12768	56506-56512	NNP	denotes	States
T12769	56512-56513	-RRB-	denotes	)
T12770	56514-56516	TO	denotes	to
T12771	56517-56525	VB	denotes	identify
T12772	56526-56531	NNS	denotes	cells
T12773	56532-56534	IN	denotes	in
T12774	56535-56542	NN	denotes	mitosis
T12775	56542-56543	.	denotes	.
T12776	56543-56619	sentence	denotes	Cy3-labeled anti-rabbit secondary antibody was used to detect the antibody.
T12777	56544-56547	NN	denotes	Cy3
T12778	56548-56555	VBN	denotes	labeled
T12779	56547-56548	HYPH	denotes	-
T12780	56578-56586	NN	denotes	antibody
T12781	56556-56567	JJ	denotes	anti-rabbit
T12782	56568-56577	JJ	denotes	secondary
T12783	56591-56595	VBN	denotes	used
T12784	56587-56590	VBD	denotes	was
T12785	56596-56598	TO	denotes	to
T12786	56599-56605	VB	denotes	detect
T12787	56606-56609	DT	denotes	the
T12788	56610-56618	NN	denotes	antibody
T12789	56618-56619	.	denotes	.
T12790	56619-56792	sentence	denotes	Cell nuclei were labeled with DAPI, and slides were mounted in Vectamount (Vector Laboratories, Burlingame, California, United States) and visualized at 100× magnification.
T12791	56620-56624	NN	denotes	Cell
T12792	56625-56631	NNS	denotes	nuclei
T12793	56637-56644	VBN	denotes	labeled
T12794	56632-56636	VBD	denotes	were
T12795	56645-56649	IN	denotes	with
T12796	56650-56654	NN	denotes	DAPI
T12797	56654-56656	,	denotes	,
T12798	56656-56659	CC	denotes	and
T12799	56660-56666	NNS	denotes	slides
T12800	56672-56679	VBN	denotes	mounted
T12801	56667-56671	VBD	denotes	were
T12802	56680-56682	IN	denotes	in
T12803	56683-56693	NNP	denotes	Vectamount
T12804	56694-56695	-LRB-	denotes	(
T12805	56702-56714	NNP	denotes	Laboratories
T12806	56695-56701	NNP	denotes	Vector
T12807	56714-56716	,	denotes	,
T12808	56716-56726	NNP	denotes	Burlingame
T12809	56726-56728	,	denotes	,
T12810	56728-56738	NNP	denotes	California
T12811	56738-56740	,	denotes	,
T12812	56740-56746	NNP	denotes	United
T12813	56747-56753	NNP	denotes	States
T12814	56753-56754	-RRB-	denotes	)
T12815	56755-56758	CC	denotes	and
T12816	56759-56769	VBN	denotes	visualized
T12817	56770-56772	IN	denotes	at
T12818	56773-56776	CD	denotes	100
T12819	56778-56791	NN	denotes	magnification
T12820	56776-56777	SYM	denotes	×
T12821	56791-56792	.	denotes	.
T12822	56792-57032	sentence	denotes	The area of selected anatomical sites were measured, and the number of TUNEL-labeled nuclear fragments and the number of Cy3-labeled nuclei were counted from three 10-μm sections spanning 50 μm, from three control and three mutant animals.
T12823	56793-56796	DT	denotes	The
T12824	56797-56801	NN	denotes	area
T12825	56836-56844	VBN	denotes	measured
T12826	56802-56804	IN	denotes	of
T12827	56805-56813	VBN	denotes	selected
T12828	56825-56830	NNS	denotes	sites
T12829	56814-56824	JJ	denotes	anatomical
T12830	56831-56835	VBD	denotes	were
T12831	56844-56846	,	denotes	,
T12832	56846-56849	CC	denotes	and
T12833	56850-56853	DT	denotes	the
T12834	56854-56860	NN	denotes	number
T12835	56938-56945	VBN	denotes	counted
T12836	56861-56863	IN	denotes	of
T12837	56864-56869	NN	denotes	TUNEL
T12838	56870-56877	VBN	denotes	labeled
T12839	56869-56870	HYPH	denotes	-
T12840	56886-56895	NNS	denotes	fragments
T12841	56878-56885	JJ	denotes	nuclear
T12842	56896-56899	CC	denotes	and
T12843	56900-56903	DT	denotes	the
T12844	56904-56910	NN	denotes	number
T12845	56911-56913	IN	denotes	of
T12846	56914-56917	NN	denotes	Cy3
T12847	56918-56925	VBN	denotes	labeled
T12848	56917-56918	HYPH	denotes	-
T12849	56926-56932	NNS	denotes	nuclei
T12850	56933-56937	VBD	denotes	were
T12851	56946-56950	IN	denotes	from
T12852	56951-56956	CD	denotes	three
T12853	56963-56971	NNS	denotes	sections
T12854	56957-56959	CD	denotes	10
T12855	56960-56962	NN	denotes	μm
T12856	56959-56960	HYPH	denotes	-
T12857	56972-56980	VBG	denotes	spanning
T12858	56981-56983	CD	denotes	50
T12859	56984-56986	NN	denotes	μm
T12860	56986-56988	,	denotes	,
T12861	56988-56992	IN	denotes	from
T12862	56993-56998	CD	denotes	three
T12863	56999-57006	NN	denotes	control
T12864	57007-57010	CC	denotes	and
T12865	57011-57016	CD	denotes	three
T12866	57017-57023	NN	denotes	mutant
T12867	57024-57031	NNS	denotes	animals
T12868	57031-57032	.	denotes	.
T12869	57032-57204	sentence	denotes	The number of labeled cells in the metacarpal-phalangeal and metatarsal-phalangeal joints was counted in a 290 μm × 365 μm rectangle placed around the center of the joint.
T12870	57033-57036	DT	denotes	The
T12871	57037-57043	NN	denotes	number
T12872	57127-57134	VBN	denotes	counted
T12873	57044-57046	IN	denotes	of
T12874	57047-57054	VBN	denotes	labeled
T12875	57055-57060	NNS	denotes	cells
T12876	57061-57063	IN	denotes	in
T12877	57064-57067	DT	denotes	the
T12878	57116-57122	NNS	denotes	joints
T12879	57068-57078	JJ	denotes	metacarpal
T12880	57079-57089	JJ	denotes	phalangeal
T12881	57078-57079	HYPH	denotes	-
T12882	57090-57093	CC	denotes	and
T12883	57094-57104	JJ	denotes	metatarsal
T12884	57105-57115	JJ	denotes	phalangeal
T12885	57104-57105	HYPH	denotes	-
T12886	57123-57126	VBD	denotes	was
T12887	57135-57137	IN	denotes	in
T12888	57138-57139	DT	denotes	a
T12889	57156-57165	NN	denotes	rectangle
T12890	57140-57143	CD	denotes	290
T12891	57144-57146	NN	denotes	μm
T12892	57147-57148	SYM	denotes	×
T12893	57153-57155	NN	denotes	μm
T12894	57149-57152	CD	denotes	365
T12895	57166-57172	VBN	denotes	placed
T12896	57173-57179	IN	denotes	around
T12897	57180-57183	DT	denotes	the
T12898	57184-57190	NN	denotes	center
T12899	57191-57193	IN	denotes	of
T12900	57194-57197	DT	denotes	the
T12901	57198-57203	NN	denotes	joint
T12902	57203-57204	.	denotes	.
T12903	57204-57359	sentence	denotes	The posterior region of the fifth digit was defined by drawing a line from the tip of the digit down 2.15 mm and across to the lateral edge of the tissue.
T12904	57205-57208	DT	denotes	The
T12905	57219-57225	NN	denotes	region
T12906	57209-57218	JJ	denotes	posterior
T12907	57249-57256	VBN	denotes	defined
T12908	57226-57228	IN	denotes	of
T12909	57229-57232	DT	denotes	the
T12910	57239-57244	NN	denotes	digit
T12911	57233-57238	JJ	denotes	fifth
T12912	57245-57248	VBD	denotes	was
T12913	57257-57259	IN	denotes	by
T12914	57260-57267	VBG	denotes	drawing
T12915	57268-57269	DT	denotes	a
T12916	57270-57274	NN	denotes	line
T12917	57275-57279	IN	denotes	from
T12918	57280-57283	DT	denotes	the
T12919	57284-57287	NN	denotes	tip
T12920	57288-57290	IN	denotes	of
T12921	57291-57294	DT	denotes	the
T12922	57295-57300	NN	denotes	digit
T12923	57301-57305	IN	denotes	down
T12924	57306-57310	CD	denotes	2.15
T12925	57311-57313	NN	denotes	mm
T12926	57314-57317	CC	denotes	and
T12927	57318-57324	IN	denotes	across
T12928	57325-57327	IN	denotes	to
T12929	57328-57331	DT	denotes	the
T12930	57340-57344	NN	denotes	edge
T12931	57332-57339	JJ	denotes	lateral
T12932	57345-57347	IN	denotes	of
T12933	57348-57351	DT	denotes	the
T12934	57352-57358	NN	denotes	tissue
T12935	57358-57359	.	denotes	.
T12936	57359-57417	sentence	denotes	For this analysis, the R26R Cre reporter was not present.
T12937	57360-57363	IN	denotes	For
T12938	57401-57404	VBD	denotes	was
T12939	57364-57368	DT	denotes	this
T12940	57369-57377	NN	denotes	analysis
T12941	57377-57379	,	denotes	,
T12942	57379-57382	DT	denotes	the
T12943	57392-57400	NN	denotes	reporter
T12944	57383-57387	NN	denotes	R26R
T12945	57388-57391	NN	denotes	Cre
T12946	57405-57408	RB	denotes	not
T12947	57409-57416	JJ	denotes	present
T12948	57416-57417	.	denotes	.
T13137	57419-57428	NN	denotes	Histology
T13138	57429-57432	CC	denotes	and
T13139	57433-57447	NN	denotes	histochemistry
T13140	57447-57778	sentence	denotes	Tissue from animals ranging from stages E14.5 to P14 was prepared for analysis by fixing in 4% paraformaldehyde (PFA) in PBS for 45 min to 4 h depending on the stage; washing three times in PBS, once in PBS + 15% sucrose for 1 h, and once in PBS + 30% sucrose for 2 h to overnight depending on the stage; and then freezing in OCT.
T13141	57448-57454	NN	denotes	Tissue
T13142	57505-57513	VBN	denotes	prepared
T13143	57455-57459	IN	denotes	from
T13144	57460-57467	NNS	denotes	animals
T13145	57468-57475	VBG	denotes	ranging
T13146	57476-57480	IN	denotes	from
T13147	57481-57487	NNS	denotes	stages
T13148	57488-57493	NN	denotes	E14.5
T13149	57494-57496	IN	denotes	to
T13150	57497-57500	NN	denotes	P14
T13151	57501-57504	VBD	denotes	was
T13152	57514-57517	IN	denotes	for
T13153	57518-57526	NN	denotes	analysis
T13154	57527-57529	IN	denotes	by
T13155	57530-57536	VBG	denotes	fixing
T13156	57537-57539	IN	denotes	in
T13157	57540-57541	CD	denotes	4
T13158	57541-57542	NN	denotes	%
T13159	57543-57559	NN	denotes	paraformaldehyde
T13160	57560-57561	-LRB-	denotes	(
T13161	57561-57564	NN	denotes	PFA
T13162	57564-57565	-RRB-	denotes	)
T13163	57566-57568	IN	denotes	in
T13164	57569-57572	NN	denotes	PBS
T13165	57573-57576	IN	denotes	for
T13166	57577-57579	CD	denotes	45
T13167	57580-57583	NN	denotes	min
T13168	57584-57586	IN	denotes	to
T13169	57587-57588	CD	denotes	4
T13170	57589-57590	NN	denotes	h
T13171	57591-57600	VBG	denotes	depending
T13172	57601-57603	IN	denotes	on
T13173	57604-57607	DT	denotes	the
T13174	57608-57613	NN	denotes	stage
T13175	57613-57614	:	denotes	;
T13176	57615-57622	VBG	denotes	washing
T13177	57623-57628	CD	denotes	three
T13178	57629-57634	NNS	denotes	times
T13179	57635-57637	IN	denotes	in
T13180	57638-57641	NN	denotes	PBS
T13181	57641-57643	,	denotes	,
T13182	57643-57647	RB	denotes	once
T13183	57648-57650	IN	denotes	in
T13184	57651-57654	NN	denotes	PBS
T13185	57655-57656	SYM	denotes	+
T13186	57657-57659	CD	denotes	15
T13187	57659-57660	NN	denotes	%
T13188	57661-57668	NN	denotes	sucrose
T13189	57669-57672	IN	denotes	for
T13190	57673-57674	CD	denotes	1
T13191	57675-57676	NN	denotes	h
T13192	57676-57678	,	denotes	,
T13193	57678-57681	CC	denotes	and
T13194	57682-57686	RB	denotes	once
T13195	57687-57689	IN	denotes	in
T13196	57690-57693	NN	denotes	PBS
T13197	57694-57695	SYM	denotes	+
T13198	57696-57698	CD	denotes	30
T13199	57698-57699	NN	denotes	%
T13200	57700-57707	NN	denotes	sucrose
T13201	57708-57711	IN	denotes	for
T13202	57712-57713	CD	denotes	2
T13203	57714-57715	NN	denotes	h
T13204	57716-57718	IN	denotes	to
T13205	57719-57728	NN	denotes	overnight
T13206	57729-57738	VBG	denotes	depending
T13207	57739-57741	IN	denotes	on
T13208	57742-57745	DT	denotes	the
T13209	57746-57751	NN	denotes	stage
T13210	57751-57752	:	denotes	;
T13211	57753-57756	CC	denotes	and
T13212	57757-57761	RB	denotes	then
T13213	57762-57770	VBG	denotes	freezing
T13214	57771-57773	IN	denotes	in
T13215	57774-57777	NN	denotes	OCT
T13216	57777-57778	.	denotes	.
T13217	57778-57952	sentence	denotes	Tissue from animals aged 7 wk to 9 mo was processed similarly to earlier stages except that it was decalcified in 0.5 M EDTA (pH 7.4) for 4 d prior to incubating in sucrose.
T13218	57779-57785	NN	denotes	Tissue
T13219	57821-57830	VBN	denotes	processed
T13220	57786-57790	IN	denotes	from
T13221	57791-57798	NNS	denotes	animals
T13222	57799-57803	VBN	denotes	aged
T13223	57804-57805	CD	denotes	7
T13224	57806-57808	NNS	denotes	wk
T13225	57809-57811	IN	denotes	to
T13226	57812-57813	CD	denotes	9
T13227	57814-57816	NNS	denotes	mo
T13228	57817-57820	VBD	denotes	was
T13229	57831-57840	RB	denotes	similarly
T13230	57841-57843	IN	denotes	to
T13231	57844-57851	JJR	denotes	earlier
T13232	57852-57858	NNS	denotes	stages
T13233	57859-57865	IN	denotes	except
T13234	57866-57870	IN	denotes	that
T13235	57878-57889	VBN	denotes	decalcified
T13236	57871-57873	PRP	denotes	it
T13237	57874-57877	VBD	denotes	was
T13238	57890-57892	IN	denotes	in
T13239	57893-57896	CD	denotes	0.5
T13240	57897-57898	NN	denotes	M
T13241	57899-57903	NN	denotes	EDTA
T13242	57904-57905	-LRB-	denotes	(
T13243	57905-57907	NN	denotes	pH
T13244	57908-57911	CD	denotes	7.4
T13245	57911-57912	-RRB-	denotes	)
T13246	57913-57916	IN	denotes	for
T13247	57917-57918	CD	denotes	4
T13248	57919-57920	NN	denotes	d
T13249	57921-57926	JJ	denotes	prior
T13250	57927-57929	IN	denotes	to
T13251	57930-57940	VBG	denotes	incubating
T13252	57941-57943	IN	denotes	in
T13253	57944-57951	NN	denotes	sucrose
T13254	57951-57952	.	denotes	.
T13255	57952-58103	sentence	denotes	All solutions were prechilled and used at 4 °C with agitation, and skin from tissues of P0 or older mice was lacerated or removed prior to processing.
T13256	57953-57956	DT	denotes	All
T13257	57957-57966	NNS	denotes	solutions
T13258	57972-57982	VBN	denotes	prechilled
T13259	57967-57971	VBD	denotes	were
T13260	57983-57986	CC	denotes	and
T13261	57987-57991	VBN	denotes	used
T13262	57992-57994	IN	denotes	at
T13263	57995-57996	CD	denotes	4
T13264	57997-57999	NN	denotes	°C
T13265	58000-58004	IN	denotes	with
T13266	58005-58014	NN	denotes	agitation
T13267	58014-58016	,	denotes	,
T13268	58016-58019	CC	denotes	and
T13269	58020-58024	NN	denotes	skin
T13270	58062-58071	VBN	denotes	lacerated
T13271	58025-58029	IN	denotes	from
T13272	58030-58037	NNS	denotes	tissues
T13273	58038-58040	IN	denotes	of
T13274	58041-58043	NN	denotes	P0
T13275	58053-58057	NNS	denotes	mice
T13276	58044-58046	CC	denotes	or
T13277	58047-58052	JJR	denotes	older
T13278	58058-58061	VBD	denotes	was
T13279	58072-58074	CC	denotes	or
T13280	58075-58082	VBN	denotes	removed
T13281	58083-58088	JJ	denotes	prior
T13282	58089-58091	IN	denotes	to
T13283	58092-58102	NN	denotes	processing
T13284	58102-58103	.	denotes	.
T13285	58103-58157	sentence	denotes	Tissue was then cryosectioned at 12 μm and processed.
T13286	58104-58110	NN	denotes	Tissue
T13287	58120-58133	VBN	denotes	cryosectioned
T13288	58111-58114	VBD	denotes	was
T13289	58115-58119	RB	denotes	then
T13290	58134-58136	IN	denotes	at
T13291	58137-58139	CD	denotes	12
T13292	58140-58142	NN	denotes	μm
T13293	58143-58146	CC	denotes	and
T13294	58147-58156	VBN	denotes	processed
T13295	58156-58157	.	denotes	.
T13296	58157-58287	sentence	denotes	Staining of sections with Safranin O, Fast Green, and Harris' hematoxylin was carried out using standard histological procedures.
T13297	58158-58166	NN	denotes	Staining
T13298	58236-58243	VBN	denotes	carried
T13299	58167-58169	IN	denotes	of
T13300	58170-58178	NNS	denotes	sections
T13301	58179-58183	IN	denotes	with
T13302	58184-58192	NN	denotes	Safranin
T13303	58193-58194	NN	denotes	O
T13304	58194-58196	,	denotes	,
T13305	58196-58200	JJ	denotes	Fast
T13306	58201-58206	NN	denotes	Green
T13307	58206-58208	,	denotes	,
T13308	58208-58211	CC	denotes	and
T13309	58212-58218	NNP	denotes	Harris
T13310	58220-58231	NN	denotes	hematoxylin
T13311	58218-58219	POS	denotes	'
T13312	58232-58235	VBD	denotes	was
T13313	58244-58247	RP	denotes	out
T13314	58248-58253	VBG	denotes	using
T13315	58254-58262	JJ	denotes	standard
T13316	58276-58286	NNS	denotes	procedures
T13317	58263-58275	JJ	denotes	histological
T13318	58286-58287	.	denotes	.
T13319	58287-58607	sentence	denotes	Detection of LACZ activity with X-Gal was performed as described (Lobe et al. 1999) and was followed by refixing in 4% PFA, rinsing with deionized water, counterstaining with Nuclear Fast Red (Vector Labs), rinsing with water again, and then mounting in Aquamount (Lerner Labs, Pittsburgh, Pennsylvania, United States).
T13320	58288-58297	NN	denotes	Detection
T13321	58330-58339	VBN	denotes	performed
T13322	58298-58300	IN	denotes	of
T13323	58301-58305	NN	denotes	LACZ
T13324	58306-58314	NN	denotes	activity
T13325	58315-58319	IN	denotes	with
T13326	58320-58321	NN	denotes	X
T13327	58322-58325	NN	denotes	Gal
T13328	58321-58322	HYPH	denotes	-
T13329	58326-58329	VBD	denotes	was
T13330	58340-58342	IN	denotes	as
T13331	58343-58352	VBN	denotes	described
T13332	58353-58354	-LRB-	denotes	(
T13333	58354-58358	NNP	denotes	Lobe
T13334	58359-58361	FW	denotes	et
T13335	58362-58365	FW	denotes	al.
T13336	58366-58370	CD	denotes	1999
T13337	58370-58371	-RRB-	denotes	)
T13338	58372-58375	CC	denotes	and
T13339	58376-58379	VBD	denotes	was
T13340	58380-58388	VBN	denotes	followed
T13341	58389-58391	IN	denotes	by
T13342	58392-58400	VBG	denotes	refixing
T13343	58401-58403	IN	denotes	in
T13344	58404-58405	CD	denotes	4
T13345	58405-58406	NN	denotes	%
T13346	58407-58410	NN	denotes	PFA
T13347	58410-58412	,	denotes	,
T13348	58412-58419	VBG	denotes	rinsing
T13349	58420-58424	IN	denotes	with
T13350	58425-58434	VBN	denotes	deionized
T13351	58435-58440	NN	denotes	water
T13352	58440-58442	,	denotes	,
T13353	58442-58457	VBG	denotes	counterstaining
T13354	58458-58462	IN	denotes	with
T13355	58463-58470	JJ	denotes	Nuclear
T13356	58476-58479	NN	denotes	Red
T13357	58471-58475	JJ	denotes	Fast
T13358	58480-58481	-LRB-	denotes	(
T13359	58481-58487	NNP	denotes	Vector
T13360	58488-58492	NNP	denotes	Labs
T13361	58492-58493	-RRB-	denotes	)
T13362	58493-58495	,	denotes	,
T13363	58495-58502	VBG	denotes	rinsing
T13364	58503-58507	IN	denotes	with
T13365	58508-58513	NN	denotes	water
T13366	58514-58519	RB	denotes	again
T13367	58519-58521	,	denotes	,
T13368	58521-58524	CC	denotes	and
T13369	58525-58529	RB	denotes	then
T13370	58530-58538	VBG	denotes	mounting
T13371	58539-58541	IN	denotes	in
T13372	58542-58551	NN	denotes	Aquamount
T13373	58552-58553	-LRB-	denotes	(
T13374	58560-58564	NNP	denotes	Labs
T13375	58553-58559	NNP	denotes	Lerner
T13376	58564-58566	,	denotes	,
T13377	58566-58576	NNP	denotes	Pittsburgh
T13378	58576-58578	,	denotes	,
T13379	58578-58590	NNP	denotes	Pennsylvania
T13380	58590-58592	,	denotes	,
T13381	58592-58598	NNP	denotes	United
T13382	58599-58605	NNP	denotes	States
T13383	58605-58606	-RRB-	denotes	)
T13384	58606-58607	.	denotes	.
T13385	58607-59083	sentence	denotes	RNA in situ hybridization was performed as described (Storm and Kingsley 1996), with the following modifications: (1) Prior to the acetylation step, sections were incubated with 10–20 μg/ml proteinase K for 30 s to 7 min at room temperature (depending on the developmental stage), followed by refixing in 4% PFA and washing three times in PBS; (2) prehybridization step was skipped, and (3) embryonic tissue sections used a different color development mix (Thut et al. 2001).
T13386	58608-58611	NN	denotes	RNA
T13387	58620-58633	NN	denotes	hybridization
T13388	58612-58614	FW	denotes	in
T13389	58615-58619	FW	denotes	situ
T13390	58638-58647	VBN	denotes	performed
T13391	58634-58637	VBD	denotes	was
T13392	58648-58650	IN	denotes	as
T13393	58651-58660	VBN	denotes	described
T13394	58661-58662	-LRB-	denotes	(
T13395	58662-58667	NNP	denotes	Storm
T13396	58668-58671	CC	denotes	and
T13397	58672-58680	NNP	denotes	Kingsley
T13398	58681-58685	CD	denotes	1996
T13399	58685-58686	-RRB-	denotes	)
T13400	58686-58688	,	denotes	,
T13401	58688-58692	IN	denotes	with
T13402	58693-58696	DT	denotes	the
T13403	58707-58720	NNS	denotes	modifications
T13404	58697-58706	VBG	denotes	following
T13405	58720-58722	:	denotes	:
T13406	58722-58723	-LRB-	denotes	(
T13407	58723-58724	LS	denotes	1
T13408	58771-58780	VBN	denotes	incubated
T13409	58724-58725	-RRB-	denotes	)
T13410	58726-58731	JJ	denotes	Prior
T13411	58732-58734	IN	denotes	to
T13412	58735-58738	DT	denotes	the
T13413	58751-58755	NN	denotes	step
T13414	58739-58750	NN	denotes	acetylation
T13415	58755-58757	,	denotes	,
T13416	58757-58765	NNS	denotes	sections
T13417	58766-58770	VBD	denotes	were
T13418	58781-58785	IN	denotes	with
T13419	58786-58788	CD	denotes	10
T13420	58789-58791	CD	denotes	20
T13421	58788-58789	HYPH	denotes	–
T13422	58792-58794	NNS	denotes	μg
T13423	58809-58810	NN	denotes	K
T13424	58794-58795	SYM	denotes	/
T13425	58795-58797	NN	denotes	ml
T13426	58798-58808	NN	denotes	proteinase
T13427	58811-58814	IN	denotes	for
T13428	58815-58817	CD	denotes	30
T13429	58818-58819	NN	denotes	s
T13430	58820-58822	IN	denotes	to
T13431	58823-58824	CD	denotes	7
T13432	58825-58828	NN	denotes	min
T13433	58829-58831	IN	denotes	at
T13434	58832-58836	NN	denotes	room
T13435	58837-58848	NN	denotes	temperature
T13436	58849-58850	-LRB-	denotes	(
T13437	58850-58859	VBG	denotes	depending
T13438	58860-58862	IN	denotes	on
T13439	58863-58866	DT	denotes	the
T13440	58881-58886	NN	denotes	stage
T13441	58867-58880	JJ	denotes	developmental
T13442	58886-58887	-RRB-	denotes	)
T13443	58887-58889	,	denotes	,
T13444	58889-58897	VBN	denotes	followed
T13445	58898-58900	IN	denotes	by
T13446	58901-58909	VBG	denotes	refixing
T13447	58910-58912	IN	denotes	in
T13448	58913-58914	CD	denotes	4
T13449	58914-58915	NN	denotes	%
T13450	58916-58919	NN	denotes	PFA
T13451	58920-58923	CC	denotes	and
T13452	58924-58931	VBG	denotes	washing
T13453	58932-58937	CD	denotes	three
T13454	58938-58943	NNS	denotes	times
T13455	58944-58946	IN	denotes	in
T13456	58947-58950	NN	denotes	PBS
T13457	58950-58951	:	denotes	;
T13458	58952-58953	-LRB-	denotes	(
T13459	58953-58954	LS	denotes	2
T13460	58982-58989	VBN	denotes	skipped
T13461	58954-58955	-RRB-	denotes	)
T13462	58956-58972	NN	denotes	prehybridization
T13463	58973-58977	NN	denotes	step
T13464	58978-58981	VBD	denotes	was
T13465	58989-58991	,	denotes	,
T13466	58991-58994	CC	denotes	and
T13467	58995-58996	-LRB-	denotes	(
T13468	58996-58997	LS	denotes	3
T13469	59025-59029	VBD	denotes	used
T13470	58997-58998	-RRB-	denotes	)
T13471	58999-59008	JJ	denotes	embryonic
T13472	59009-59015	NN	denotes	tissue
T13473	59016-59024	NNS	denotes	sections
T13474	59030-59031	DT	denotes	a
T13475	59060-59063	NN	denotes	mix
T13476	59032-59041	JJ	denotes	different
T13477	59042-59047	NN	denotes	color
T13478	59048-59059	NN	denotes	development
T13479	59064-59065	-LRB-	denotes	(
T13480	59065-59069	NNP	denotes	Thut
T13481	59070-59072	FW	denotes	et
T13482	59073-59076	FW	denotes	al.
T13483	59077-59081	CD	denotes	2001
T13484	59081-59082	-RRB-	denotes	)
T13485	59082-59083	.	denotes	.
T13486	59083-59346	sentence	denotes	Probes for the following genes have been published previously: Bmpr1a (Mishina et al. 1995), Col2a1 (Metsaranta et al. 1991), Col10a1 (Apte et al. 1992), Gdf5 (Storm and Kingsley 1996), Osteocalcin (Celeste et al. 1986), and Sox5 and Sox6 (Lefebvre et al. 1998).
T13487	59084-59090	NNS	denotes	Probes
T13488	59125-59134	VBN	denotes	published
T13489	59091-59094	IN	denotes	for
T13490	59095-59098	DT	denotes	the
T13491	59109-59114	NNS	denotes	genes
T13492	59099-59108	VBG	denotes	following
T13493	59115-59119	VBP	denotes	have
T13494	59120-59124	VBN	denotes	been
T13495	59135-59145	RB	denotes	previously
T13496	59145-59147	:	denotes	:
T13497	59147-59153	NN	denotes	Bmpr1a
T13498	59154-59155	-LRB-	denotes	(
T13499	59155-59162	NNP	denotes	Mishina
T13500	59163-59165	FW	denotes	et
T13501	59166-59169	FW	denotes	al.
T13502	59170-59174	CD	denotes	1995
T13503	59174-59175	-RRB-	denotes	)
T13504	59175-59177	,	denotes	,
T13505	59177-59183	NN	denotes	Col2a1
T13506	59184-59185	-LRB-	denotes	(
T13507	59185-59195	NNP	denotes	Metsaranta
T13508	59196-59198	FW	denotes	et
T13509	59199-59202	FW	denotes	al.
T13510	59203-59207	CD	denotes	1991
T13511	59207-59208	-RRB-	denotes	)
T13512	59208-59210	,	denotes	,
T13513	59210-59217	NN	denotes	Col10a1
T13514	59218-59219	-LRB-	denotes	(
T13515	59219-59223	NNP	denotes	Apte
T13516	59224-59226	FW	denotes	et
T13517	59227-59230	FW	denotes	al.
T13518	59231-59235	CD	denotes	1992
T13519	59235-59236	-RRB-	denotes	)
T13520	59236-59238	,	denotes	,
T13521	59238-59242	NN	denotes	Gdf5
T13522	59243-59244	-LRB-	denotes	(
T13523	59244-59249	NNP	denotes	Storm
T13524	59250-59253	CC	denotes	and
T13525	59254-59262	NNP	denotes	Kingsley
T13526	59263-59267	CD	denotes	1996
T13527	59267-59268	-RRB-	denotes	)
T13528	59268-59270	,	denotes	,
T13529	59270-59281	NN	denotes	Osteocalcin
T13530	59282-59283	-LRB-	denotes	(
T13531	59283-59290	NNP	denotes	Celeste
T13532	59291-59293	FW	denotes	et
T13533	59294-59297	FW	denotes	al.
T13534	59298-59302	CD	denotes	1986
T13535	59302-59303	-RRB-	denotes	)
T13536	59303-59305	,	denotes	,
T13537	59305-59308	CC	denotes	and
T13538	59309-59313	NN	denotes	Sox5
T13539	59314-59317	CC	denotes	and
T13540	59318-59322	NN	denotes	Sox6
T13541	59323-59324	-LRB-	denotes	(
T13542	59324-59332	NNP	denotes	Lefebvre
T13543	59333-59335	FW	denotes	et
T13544	59336-59339	FW	denotes	al.
T13545	59340-59344	CD	denotes	1998
T13546	59344-59345	-RRB-	denotes	)
T13547	59345-59346	.	denotes	.
T13548	59346-59694	sentence	denotes	The following probe templates were gifts: Agg, Dr. Vicki Rosen, Genetics Institute; Bmp2 and Bmp4, Arend Sidow, Stanford University; Col1a1, Bjorn Olsen, Harvard Medical School; Bmpr1b, Col3a1, and Mat4 probes were made from ESTs with IMAGE clone numbers 5056341, 478480, and 406027, respectively (Invitrogen, Carlsbad, California, United States).
T13549	59347-59350	DT	denotes	The
T13550	59367-59376	NNS	denotes	templates
T13551	59351-59360	VBG	denotes	following
T13552	59361-59366	NN	denotes	probe
T13553	59377-59381	VBD	denotes	were
T13554	59562-59566	VBN	denotes	made
T13555	59382-59387	NNS	denotes	gifts
T13556	59387-59389	:	denotes	:
T13557	59389-59392	NN	denotes	Agg
T13558	59392-59394	,	denotes	,
T13559	59394-59397	NNP	denotes	Dr.
T13560	59404-59409	NNP	denotes	Rosen
T13561	59398-59403	NNP	denotes	Vicki
T13562	59409-59411	,	denotes	,
T13563	59411-59419	NNP	denotes	Genetics
T13564	59420-59429	NNP	denotes	Institute
T13565	59429-59430	:	denotes	;
T13566	59431-59435	NN	denotes	Bmp2
T13567	59436-59439	CC	denotes	and
T13568	59440-59444	NN	denotes	Bmp4
T13569	59444-59446	,	denotes	,
T13570	59446-59451	NNP	denotes	Arend
T13571	59452-59457	NNP	denotes	Sidow
T13572	59457-59459	,	denotes	,
T13573	59459-59467	NNP	denotes	Stanford
T13574	59468-59478	NNP	denotes	University
T13575	59478-59479	:	denotes	;
T13576	59480-59486	NN	denotes	Col1a1
T13577	59486-59488	,	denotes	,
T13578	59488-59493	NNP	denotes	Bjorn
T13579	59494-59499	NNP	denotes	Olsen
T13580	59499-59501	,	denotes	,
T13581	59501-59508	NNP	denotes	Harvard
T13582	59517-59523	NNP	denotes	School
T13583	59509-59516	NNP	denotes	Medical
T13584	59523-59524	:	denotes	;
T13585	59525-59531	NN	denotes	Bmpr1b
T13586	59550-59556	NNS	denotes	probes
T13587	59531-59533	,	denotes	,
T13588	59533-59539	NN	denotes	Col3a1
T13589	59539-59541	,	denotes	,
T13590	59541-59544	CC	denotes	and
T13591	59545-59549	NN	denotes	Mat4
T13592	59557-59561	VBD	denotes	were
T13593	59567-59571	IN	denotes	from
T13594	59572-59576	NNS	denotes	ESTs
T13595	59577-59581	IN	denotes	with
T13596	59582-59587	NN	denotes	IMAGE
T13597	59594-59601	NNS	denotes	numbers
T13598	59588-59593	NN	denotes	clone
T13599	59602-59609	CD	denotes	5056341
T13600	59609-59611	,	denotes	,
T13601	59611-59617	CD	denotes	478480
T13602	59617-59619	,	denotes	,
T13603	59619-59622	CC	denotes	and
T13604	59623-59629	CD	denotes	406027
T13605	59629-59631	,	denotes	,
T13606	59631-59643	RB	denotes	respectively
T13607	59644-59645	-LRB-	denotes	(
T13608	59645-59655	NNP	denotes	Invitrogen
T13609	59655-59657	,	denotes	,
T13610	59657-59665	NNP	denotes	Carlsbad
T13611	59665-59667	,	denotes	,
T13612	59667-59677	NNP	denotes	California
T13613	59677-59679	,	denotes	,
T13614	59679-59685	NNP	denotes	United
T13615	59686-59692	NNP	denotes	States
T13616	59692-59693	-RRB-	denotes	)
T13617	59693-59694	.	denotes	.
T13618	59694-59925	sentence	denotes	Sections for immunohistochemistry were fixed in 4% PFA, then digested with 942–2,000 U/ml type IV-S bovine hyaluronindase (Sigma, St. Louis, Missouri, United States) in PBS (pH 5) at 37 °C for 30 min to 2 h depending on the stage.
T13619	59695-59703	NNS	denotes	Sections
T13620	59734-59739	VBN	denotes	fixed
T13621	59704-59707	IN	denotes	for
T13622	59708-59728	NN	denotes	immunohistochemistry
T13623	59729-59733	VBD	denotes	were
T13624	59740-59742	IN	denotes	in
T13625	59743-59744	CD	denotes	4
T13626	59744-59745	NN	denotes	%
T13627	59746-59749	NN	denotes	PFA
T13628	59749-59751	,	denotes	,
T13629	59751-59755	RB	denotes	then
T13630	59756-59764	VBN	denotes	digested
T13631	59765-59769	IN	denotes	with
T13632	59770-59773	CD	denotes	942
T13633	59774-59779	CD	denotes	2,000
T13634	59773-59774	SYM	denotes	–
T13635	59780-59781	NNS	denotes	U
T13636	59802-59816	NN	denotes	hyaluronindase
T13637	59781-59782	SYM	denotes	/
T13638	59782-59784	NN	denotes	ml
T13639	59785-59789	NN	denotes	type
T13640	59793-59794	NN	denotes	S
T13641	59790-59792	CD	denotes	IV
T13642	59792-59793	HYPH	denotes	-
T13643	59795-59801	JJ	denotes	bovine
T13644	59817-59818	-LRB-	denotes	(
T13645	59818-59823	NNP	denotes	Sigma
T13646	59823-59825	,	denotes	,
T13647	59825-59828	NNP	denotes	St.
T13648	59829-59834	NNP	denotes	Louis
T13649	59834-59836	,	denotes	,
T13650	59836-59844	NNP	denotes	Missouri
T13651	59844-59846	,	denotes	,
T13652	59846-59852	NNP	denotes	United
T13653	59853-59859	NNP	denotes	States
T13654	59859-59860	-RRB-	denotes	)
T13655	59861-59863	IN	denotes	in
T13656	59864-59867	NNS	denotes	PBS
T13657	59868-59869	-LRB-	denotes	(
T13658	59869-59871	NN	denotes	pH
T13659	59872-59873	CD	denotes	5
T13660	59873-59874	-RRB-	denotes	)
T13661	59875-59877	IN	denotes	at
T13662	59878-59880	CD	denotes	37
T13663	59881-59883	NN	denotes	°C
T13664	59884-59887	IN	denotes	for
T13665	59888-59890	CD	denotes	30
T13666	59891-59894	NN	denotes	min
T13667	59895-59897	IN	denotes	to
T13668	59898-59899	CD	denotes	2
T13669	59900-59901	NN	denotes	h
T13670	59902-59911	VBG	denotes	depending
T13671	59912-59914	IN	denotes	on
T13672	59915-59918	DT	denotes	the
T13673	59919-59924	NN	denotes	stage
T13674	59924-59925	.	denotes	.
T13675	59925-60223	sentence	denotes	Slides were then washed in PBS, treated with 0.3% hydrogen peroxide in 100% methanol for 30 min, washed, blocked with PBS + 0.05% Tween20 + 5% goat or fetal bovine serum, washed again, and incubated with primary antibodies in PBS + 0.05% Tween 20 + 1% goat or fetal bovine serum overnight at 4 °C.
T13676	59926-59932	NNS	denotes	Slides
T13677	59943-59949	VBN	denotes	washed
T13678	59933-59937	VBD	denotes	were
T13679	59938-59942	RB	denotes	then
T13680	59950-59952	IN	denotes	in
T13681	59953-59956	NN	denotes	PBS
T13682	59956-59958	,	denotes	,
T13683	59958-59965	VBN	denotes	treated
T13684	59966-59970	IN	denotes	with
T13685	59971-59974	CD	denotes	0.3
T13686	59974-59975	NN	denotes	%
T13687	59985-59993	NN	denotes	peroxide
T13688	59976-59984	NN	denotes	hydrogen
T13689	59994-59996	IN	denotes	in
T13690	59997-60000	CD	denotes	100
T13691	60000-60001	NN	denotes	%
T13692	60002-60010	NN	denotes	methanol
T13693	60011-60014	IN	denotes	for
T13694	60015-60017	CD	denotes	30
T13695	60018-60021	NN	denotes	min
T13696	60021-60023	,	denotes	,
T13697	60023-60029	VBN	denotes	washed
T13698	60029-60031	,	denotes	,
T13699	60031-60038	VBN	denotes	blocked
T13700	60039-60043	IN	denotes	with
T13701	60044-60047	NN	denotes	PBS
T13702	60048-60049	SYM	denotes	+
T13703	60050-60054	CD	denotes	0.05
T13704	60054-60055	NN	denotes	%
T13705	60056-60063	NN	denotes	Tween20
T13706	60064-60065	SYM	denotes	+
T13707	60066-60067	CD	denotes	5
T13708	60067-60068	NN	denotes	%
T13709	60090-60095	NN	denotes	serum
T13710	60069-60073	NN	denotes	goat
T13711	60074-60076	CC	denotes	or
T13712	60077-60082	JJ	denotes	fetal
T13713	60083-60089	JJ	denotes	bovine
T13714	60095-60097	,	denotes	,
T13715	60097-60103	VBD	denotes	washed
T13716	60104-60109	RB	denotes	again
T13717	60109-60111	,	denotes	,
T13718	60111-60114	CC	denotes	and
T13719	60115-60124	VBN	denotes	incubated
T13720	60125-60129	IN	denotes	with
T13721	60130-60137	JJ	denotes	primary
T13722	60138-60148	NNS	denotes	antibodies
T13723	60149-60151	IN	denotes	in
T13724	60152-60155	NN	denotes	PBS
T13725	60156-60157	SYM	denotes	+
T13726	60158-60162	CD	denotes	0.05
T13727	60162-60163	NN	denotes	%
T13728	60164-60169	NN	denotes	Tween
T13729	60170-60172	CD	denotes	20
T13730	60173-60174	SYM	denotes	+
T13731	60175-60176	CD	denotes	1
T13732	60176-60177	NN	denotes	%
T13733	60199-60204	NN	denotes	serum
T13734	60178-60182	NN	denotes	goat
T13735	60183-60185	CC	denotes	or
T13736	60186-60191	JJ	denotes	fetal
T13737	60192-60198	JJ	denotes	bovine
T13738	60205-60214	RB	denotes	overnight
T13739	60215-60217	IN	denotes	at
T13740	60218-60219	CD	denotes	4
T13741	60220-60222	NN	denotes	°C
T13742	60222-60223	.	denotes	.
T13743	60223-60389	sentence	denotes	Biotin-labeled secondary antibodies (Vector Labs) were tagged with HRP using the Vectastain Elite ABC kit (Vector Labs) followed by detection with DAB (Vector Labs).
T13744	60224-60230	NN	denotes	Biotin
T13745	60231-60238	VBN	denotes	labeled
T13746	60230-60231	HYPH	denotes	-
T13747	60249-60259	NNS	denotes	antibodies
T13748	60239-60248	JJ	denotes	secondary
T13749	60279-60285	VBN	denotes	tagged
T13750	60260-60261	-LRB-	denotes	(
T13751	60268-60272	NNS	denotes	Labs
T13752	60261-60267	NN	denotes	Vector
T13753	60272-60273	-RRB-	denotes	)
T13754	60274-60278	VBD	denotes	were
T13755	60286-60290	IN	denotes	with
T13756	60291-60294	NN	denotes	HRP
T13757	60295-60300	VBG	denotes	using
T13758	60301-60304	DT	denotes	the
T13759	60326-60329	NN	denotes	kit
T13760	60305-60315	NNP	denotes	Vectastain
T13761	60316-60321	NNP	denotes	Elite
T13762	60322-60325	NNP	denotes	ABC
T13763	60330-60331	-LRB-	denotes	(
T13764	60338-60342	NNPS	denotes	Labs
T13765	60331-60337	NNP	denotes	Vector
T13766	60342-60343	-RRB-	denotes	)
T13767	60344-60352	VBN	denotes	followed
T13768	60353-60355	IN	denotes	by
T13769	60356-60365	NN	denotes	detection
T13770	60366-60370	IN	denotes	with
T13771	60371-60374	NN	denotes	DAB
T13772	60375-60376	-LRB-	denotes	(
T13773	60383-60387	NNPS	denotes	Labs
T13774	60376-60382	NNP	denotes	Vector
T13775	60387-60388	-RRB-	denotes	)
T13776	60388-60389	.	denotes	.
T13777	60389-60660	sentence	denotes	Primary antibodies and dilutions used were: goat anti-mouse MMP13, 1:100 (Chemicon International, Temecula, California, United States); rabbit anti-human SOX9, 1:500 (Morais da Silva et al. 1996); rabbit anti-phosphorylated-SOX9 (SOX9.P), 1:10–1:250 (Huang et al. 2000).
T13778	60390-60397	JJ	denotes	Primary
T13779	60398-60408	NNS	denotes	antibodies
T13780	60428-60432	VBD	denotes	were
T13781	60409-60412	CC	denotes	and
T13782	60413-60422	NNS	denotes	dilutions
T13783	60423-60427	VBN	denotes	used
T13784	60432-60434	:	denotes	:
T13785	60434-60438	NN	denotes	goat
T13786	60450-60455	NN	denotes	MMP13
T13787	60439-60449	JJ	denotes	anti-mouse
T13788	60455-60457	,	denotes	,
T13789	60457-60458	CD	denotes	1
T13790	60458-60459	SYM	denotes	:
T13791	60459-60462	CD	denotes	100
T13792	60463-60464	-LRB-	denotes	(
T13793	60473-60486	NNP	denotes	International
T13794	60464-60472	NNP	denotes	Chemicon
T13795	60486-60488	,	denotes	,
T13796	60488-60496	NNP	denotes	Temecula
T13797	60496-60498	,	denotes	,
T13798	60498-60508	NNP	denotes	California
T13799	60508-60510	,	denotes	,
T13800	60510-60516	NNP	denotes	United
T13801	60517-60523	NNP	denotes	States
T13802	60523-60524	-RRB-	denotes	)
T13803	60524-60525	:	denotes	;
T13804	60526-60532	NN	denotes	rabbit
T13805	60544-60548	NN	denotes	SOX9
T13806	60533-60543	JJ	denotes	anti-human
T13807	60548-60550	,	denotes	,
T13808	60550-60551	CD	denotes	1
T13809	60551-60552	SYM	denotes	:
T13810	60552-60555	CD	denotes	500
T13811	60556-60557	-LRB-	denotes	(
T13812	60557-60563	NNP	denotes	Morais
T13813	60564-60566	NNP	denotes	da
T13814	60567-60572	NNP	denotes	Silva
T13815	60573-60575	FW	denotes	et
T13816	60576-60579	FW	denotes	al.
T13817	60580-60584	CD	denotes	1996
T13818	60584-60585	-RRB-	denotes	)
T13819	60585-60586	:	denotes	;
T13820	60587-60593	NN	denotes	rabbit
T13821	60614-60618	NN	denotes	SOX9
T13822	60594-60613	VBN	denotes	anti-phosphorylated
T13823	60613-60614	HYPH	denotes	-
T13824	60619-60620	-LRB-	denotes	(
T13825	60620-60624	NN	denotes	SOX9
T13826	60625-60626	NN	denotes	P
T13827	60624-60625	,	denotes	.
T13828	60626-60627	-RRB-	denotes	)
T13829	60627-60629	,	denotes	,
T13830	60629-60630	CD	denotes	1
T13831	60630-60631	SYM	denotes	:
T13832	60631-60633	CD	denotes	10
T13833	60633-60634	SYM	denotes	–
T13834	60634-60635	CD	denotes	1
T13835	60635-60636	SYM	denotes	:
T13836	60636-60639	CD	denotes	250
T13837	60640-60641	-LRB-	denotes	(
T13838	60641-60646	NNP	denotes	Huang
T13839	60647-60649	FW	denotes	et
T13840	60650-60653	FW	denotes	al.
T13841	60654-60658	CD	denotes	2000
T13842	60658-60659	-RRB-	denotes	)
T13843	60659-60660	.	denotes	.
T5156	22493-22500	NN	denotes	Failure
T5157	22501-22503	IN	denotes	of
T5158	22504-22509	JJ	denotes	Early
T5159	22516-22525	NN	denotes	Formation
T5160	22510-22515	NN	denotes	Joint
T5161	22526-22528	IN	denotes	in
T5162	22529-22534	NN	denotes	Ankle
T5163	22535-22542	NNS	denotes	Regions
T5164	22542-22645	sentence	denotes	The Bmpr1a gene is expressed in the interzone region of developing joints at E13.5 (Baur et al. 2000).
T5165	22543-22546	DT	denotes	The
T5166	22554-22558	NN	denotes	gene
T5167	22547-22553	NN	denotes	Bmpr1a
T5168	22562-22571	VBN	denotes	expressed
T5169	22559-22561	VBZ	denotes	is
T5170	22572-22574	IN	denotes	in
T5171	22575-22578	DT	denotes	the
T5172	22589-22595	NN	denotes	region
T5173	22579-22588	NN	denotes	interzone
T5174	22596-22598	IN	denotes	of
T5175	22599-22609	VBG	denotes	developing
T5176	22610-22616	NNS	denotes	joints
T5177	22617-22619	IN	denotes	at
T5178	22620-22625	NN	denotes	E13.5
T5179	22626-22627	-LRB-	denotes	(
T5180	22627-22631	NNP	denotes	Baur
T5181	22632-22634	FW	denotes	et
T5182	22635-22638	FW	denotes	al.
T5183	22639-22643	CD	denotes	2000
T5184	22643-22644	-RRB-	denotes	)
T249	83-84	sentence	denotes
R17	T247	T248	amod	Articular,Cartilage
R18	T248	T246	pobj	Cartilage,of
R19	T251	T252	amod	Articular,cartilage
R20	T252	T253	nsubj	cartilage,plays
R21	T254	T255	det	an,role
R84	T320	T321	advmod	Here,use
R85	T322	T321	nsubj	we,use
R86	T323	T324	amod	regulatory,information
R145	T384	T382	pobj	joints,in
R146	T385	T384	punct	", ",joints
R147	T386	T384	prep	including,joints
R148	T387	T388	amod	early,interzones
R149	T388	T386	pobj	interzones,including
R150	T389	T388	compound	joint,interzones
R151	T390	T388	punct	", ",interzones
R152	T391	T392	nmod	adult,cartilage
R153	T392	T388	conj	cartilage,interzones
R154	T393	T392	amod	articular,cartilage
R190	T433	T434	amod	multiple,defects
R191	T434	T432	pobj	defects,with
R192	T435	T420	punct	.,known
R193	T437	T438	advmod	However,bypasses
R194	T439	T438	punct	", ",bypasses
R195	T440	T438	csubj	combining,bypasses
R213	T458	T457	pobj	birth,to
R214	T459	T458	cc	and,birth
R223	T468	T464	prep	in,missing
R224	T469	T470	amod	articular,regions
R225	T470	T468	pobj	regions,in
R226	T471	T438	punct	.,bypasses
R227	T473	T474	amod	Most,joints
R228	T474	T475	nsubj	joints,form
R229	T476	T474	prep	in,joints
R230	T477	T478	det	the,body
R293	T546	T543	pobj	development,for
R294	T547	T546	cc	and,development
R295	T548	T546	conj	creation,development
R296	T549	T546	prep	of,development
R297	T550	T551	amod	multiple,tissues
R298	T551	T549	pobj	tissues,of
R299	T552	T543	punct	", ",for
R300	T553	T543	cc	but,for
R301	T554	T553	advmod	also,but
R302	T555	T543	conj	for,for
R303	T556	T557	amod	ongoing,maintenance
R304	T557	T555	pobj	maintenance,for
R305	T558	T557	prep	of,maintenance
R306	T559	T560	amod	articular,cartilage
R307	T560	T558	pobj	cartilage,of
R308	T561	T557	prep	after,maintenance
R309	T562	T561	pobj	birth,after
R9	T237	T238	compound	BMP,Receptor
R10	T238	T240	compound	Receptor,Signaling
R11	T240	T241	nsubjpass	Signaling,Required
R12	T242	T241	auxpass	Is,Required
R13	T243	T241	prep	for,Required
R14	T244	T245	amod	Postnatal,Maintenance
R15	T245	T243	pobj	Maintenance,for
R16	T246	T245	prep	of,Maintenance
R22	T255	T253	dobj	role,plays
R23	T256	T255	amod	essential,role
R24	T257	T253	prep	in,plays
R25	T258	T257	pobj	health,in
R26	T259	T258	cc	and,health
R27	T260	T258	conj	mobility,health
R28	T261	T253	punct	", ",plays
R29	T262	T253	cc	but,plays
R30	T263	T264	auxpass	is,damaged
R31	T264	T253	conj	damaged,plays
R32	T265	T264	advmod	frequently,damaged
R33	T266	T264	cc	or,damaged
R34	T267	T264	conj	lost,damaged
R35	T268	T267	prep	in,lost
R36	T269	T268	pobj	millions,in
R37	T270	T269	prep	of,millions
R38	T271	T270	pobj	people,of
R39	T272	T273	dep	that,develop
R40	T273	T271	relcl	develop,people
R41	T274	T273	dobj	arthritis,develop
R42	T275	T253	punct	.,plays
R43	T277	T278	det	The,mechanisms
R44	T278	T280	nsubjpass	mechanisms,understood
R45	T279	T278	amod	molecular,mechanisms
R46	T281	T282	dep	that,create
R47	T282	T278	relcl	create,mechanisms
R48	T283	T282	cc	and,create
R49	T284	T282	conj	maintain,create
R50	T285	T286	det	this,layer
R51	T286	T284	dobj	layer,maintain
R52	T287	T286	amod	thin,layer
R53	T288	T286	prep	of,layer
R54	T289	T288	pobj	cartilage,of
R55	T290	T291	dep	that,covers
R56	T291	T286	relcl	covers,layer
R57	T292	T293	det	the,surface
R58	T293	T291	dobj	surface,covers
R59	T294	T293	prep	of,surface
R60	T295	T294	pobj	bones,of
R61	T296	T291	prep	in,covers
R62	T297	T298	compound	joint,regions
R63	T298	T296	pobj	regions,in
R64	T299	T280	auxpass	are,understood
R65	T300	T280	advmod	poorly,understood
R66	T301	T280	punct	", ",understood
R67	T302	T303	prep	in,been
R68	T303	T280	advcl	been,understood
R69	T304	T302	amod	part,in
R70	T305	T303	mark	because,been
R71	T306	T303	nsubj	tools,been
R72	T307	T308	aux	to,manipulate
R73	T308	T306	advcl	manipulate,tools
R74	T309	T310	compound	gene,expression
R75	T310	T308	dobj	expression,manipulate
R76	T311	T312	advmod	specifically,in
R77	T312	T308	prep	in,manipulate
R78	T313	T314	det	this,tissue
R79	T314	T312	pobj	tissue,in
R80	T315	T303	aux	have,been
R81	T316	T303	neg	not,been
R82	T317	T303	acomp	available,been
R83	T318	T280	punct	.,understood
R87	T324	T321	dobj	information,use
R88	T325	T324	prep	from,information
R89	T326	T327	det	the,gene
R90	T327	T325	pobj	gene,from
R91	T328	T327	compound	mouse,gene
R92	T329	T327	compound	Gdf5,gene
R93	T330	T331	punct	(,member
R95	T332	T331	det	a,member
R96	T333	T334	nmod	bone,protein
R97	T334	T331	nmod	protein,member
R98	T335	T334	amod	morphogenetic,protein
R99	T336	T337	punct	[,BMP
R100	T337	T334	appos	BMP,protein
R101	T338	T337	punct	],BMP
R102	T339	T331	compound	family,member
R103	T340	T331	punct	),member
R104	T341	T342	aux	to,develop
R105	T342	T321	advcl	develop,use
R106	T343	T344	amod	new,lines
R107	T344	T342	dobj	lines,develop
R108	T345	T344	compound	mouse,lines
R109	T346	T347	dep	that,used
R110	T347	T344	relcl	used,lines
R111	T348	T347	aux	can,used
R112	T349	T347	auxpass	be,used
R113	T350	T351	aux	to,activate
R114	T351	T347	advcl	activate,used
R115	T352	T351	preconj	either,activate
R116	T353	T351	cc	or,activate
R117	T354	T351	conj	inactivate,activate
R118	T355	T354	dobj	genes,inactivate
R119	T356	T354	advmod	specifically,inactivate
R120	T357	T354	prep	in,inactivate
R121	T358	T359	amod	developing,joints
R122	T359	T357	pobj	joints,in
R123	T360	T321	punct	.,use
R124	T362	T363	nsubj	Expression,leads
R125	T364	T362	prep	of,Expression
R126	T365	T366	compound	Cre,recombinase
R127	T366	T364	pobj	recombinase,of
R128	T367	T366	prep	from,recombinase
R129	T368	T369	nmod	Gdf5,chromosome
R130	T369	T372	compound	chromosome,clones
R131	T370	T371	amod	bacterial,artificial
R132	T371	T369	amod	artificial,chromosome
R133	T372	T367	pobj	clones,from
R134	T373	T363	prep	to,leads
R135	T374	T375	amod	specific,activation
R136	T375	T373	pobj	activation,to
R137	T376	T375	cc	or,activation
R138	T377	T375	conj	inactivation,activation
R139	T378	T375	prep	of,activation
R140	T379	T380	amod	floxed,genes
R141	T380	T378	pobj	genes,of
R142	T381	T380	compound	target,genes
R143	T382	T363	prep	in,leads
R144	T383	T384	amod	developing,joints
R155	T394	T392	punct	", ",cartilage
R156	T395	T392	cc	and,cartilage
R157	T396	T397	det	the,capsule
R158	T397	T392	conj	capsule,cartilage
R159	T398	T397	compound	joint,capsule
R160	T399	T363	punct	.,leads
R161	T401	T402	nsubj	We,used
R162	T403	T402	aux	have,used
R163	T404	T405	det	this,system
R164	T405	T402	dobj	system,used
R165	T406	T407	aux	to,test
R166	T407	T402	advcl	test,used
R167	T408	T409	det	the,role
R168	T409	T407	dobj	role,test
R169	T410	T409	prep	of,role
R170	T411	T412	compound	BMP,signaling
R171	T412	T410	pobj	signaling,of
R172	T413	T412	compound	receptor,signaling
R173	T414	T409	prep	in,role
R174	T415	T416	compound	joint,development
R175	T416	T414	pobj	development,in
R176	T417	T402	punct	.,used
R177	T419	T420	nsubjpass	Mice,known
R178	T421	T419	prep	with,Mice
R179	T422	T423	amod	null,mutations
R180	T423	T421	pobj	mutations,with
R181	T424	T423	prep	in,mutations
R182	T425	T424	pobj	Bmpr1a,in
R183	T426	T420	auxpass	are,known
R184	T427	T428	aux	to,die
R185	T428	T420	xcomp	die,known
R186	T429	T428	advmod	early,die
R187	T430	T429	prep	in,early
R188	T431	T430	pobj	embryogenesis,in
R189	T432	T428	prep	with,die
R196	T441	T442	det	a,allele
R197	T442	T440	dobj	allele,combining
R198	T443	T442	amod	floxed,allele
R199	T444	T442	compound	Bmpr1a,allele
R200	T445	T440	prep	with,combining
R201	T446	T447	det	the,driver
R202	T447	T445	pobj	driver,with
R203	T448	T449	compound	Gdf5,Cre
R204	T449	T447	compound	Cre,driver
R205	T450	T449	punct	-,Cre
R206	T451	T452	det	this,lethality
R207	T452	T438	dobj	lethality,bypasses
R208	T453	T452	amod	embryonic,lethality
R209	T454	T438	punct	", ",bypasses
R210	T455	T438	cc	and,bypasses
R211	T456	T438	conj	leads,bypasses
R212	T457	T456	prep	to,leads
R215	T460	T461	amod	postnatal,development
R216	T461	T458	conj	development,birth
R217	T462	T458	prep	of,birth
R218	T463	T462	pobj	mice,of
R219	T464	T463	acl	missing,mice
R220	T465	T466	det	the,gene
R221	T466	T464	dobj	gene,missing
R222	T467	T466	compound	Bmpr1a,gene
R231	T478	T476	pobj	body,in
R232	T479	T475	advmod	normally,form
R233	T480	T475	prep	in,form
R234	T481	T482	det	the,absence
R235	T482	T480	pobj	absence,in
R236	T483	T482	prep	of,absence
R237	T484	T485	compound	Bmpr1a,receptor
R238	T485	T486	compound	receptor,function
R239	T486	T483	pobj	function,of
R240	T487	T475	punct	.,form
R241	T489	T490	advmod	However,wears
R242	T491	T490	punct	", ",wears
R243	T492	T493	amod	articular,cartilage
R244	T493	T490	nsubj	cartilage,wears
R245	T494	T493	prep	within,cartilage
R246	T495	T496	det	the,joints
R247	T496	T494	pobj	joints,within
R248	T497	T490	advmod	gradually,wears
R249	T498	T490	prt	away,wears
R250	T499	T490	prep	in,wears
R251	T500	T501	nmod	receptor,mice
R252	T501	T499	pobj	mice,in
R253	T502	T500	punct	-,receptor
R254	T503	T500	amod	deficient,receptor
R255	T504	T490	prep	after,wears
R256	T505	T504	pobj	birth,after
R257	T506	T490	prep	in,wears
R258	T507	T508	det	a,process
R259	T508	T506	pobj	process,in
R260	T509	T508	acl	resembling,process
R261	T510	T511	amod	human,osteoarthritis
R262	T511	T509	dobj	osteoarthritis,resembling
R263	T512	T490	punct	.,wears
R264	T514	T515	compound	Gdf5,Cre
R265	T515	T517	compound	Cre,mice
R266	T516	T515	punct	-,Cre
R267	T517	T518	nsubj	mice,provide
R268	T519	T520	det	a,system
R269	T520	T518	dobj	system,provide
R270	T521	T520	amod	general,system
R271	T522	T523	dep	that,used
R272	T523	T520	relcl	used,system
R273	T524	T523	aux	can,used
R274	T525	T523	auxpass	be,used
R275	T526	T527	aux	to,test
R276	T527	T523	advcl	test,used
R277	T528	T529	det	the,role
R278	T529	T527	dobj	role,test
R279	T530	T529	prep	of,role
R280	T531	T530	pobj	genes,of
R281	T532	T529	prep	in,role
R282	T533	T534	amod	articular,regions
R283	T534	T532	pobj	regions,in
R284	T535	T518	punct	.,provide
R285	T537	T538	compound	BMP,receptor
R286	T538	T539	compound	receptor,signaling
R287	T539	T540	nsubjpass	signaling,required
R288	T541	T540	auxpass	is,required
R289	T542	T543	preconj	not,for
R290	T543	T540	prep	for,required
R291	T544	T542	advmod	only,not
R292	T545	T546	amod	early,development
R310	T563	T540	punct	.,required
R311	T565	T566	amod	Genetic,variation
R312	T566	T567	nsubj	variation,be
R313	T568	T566	prep	in,variation
R314	T569	T570	det	the,strength
R315	T570	T568	pobj	strength,in
R316	T571	T570	prep	of,strength
R317	T572	T573	compound	BMP,receptor
R318	T573	T574	compound	receptor,signaling
R319	T574	T571	pobj	signaling,of
R320	T575	T567	aux	may,be
R321	T576	T577	det	an,factor
R322	T577	T567	attr	factor,be
R323	T578	T577	amod	important,factor
R324	T579	T577	compound	risk,factor
R325	T580	T567	prep	in,be
R326	T581	T582	amod	human,osteoarthritis
R327	T582	T580	pobj	osteoarthritis,in
R328	T583	T567	punct	", ",be
R329	T584	T567	cc	and,be
R330	T585	T586	nsubjpass	treatments,investigated
R331	T586	T567	conj	investigated,be
R332	T587	T588	dep	that,mimic
R333	T588	T585	relcl	mimic,treatments
R334	T589	T588	cc	or,mimic
R335	T590	T588	conj	augment,mimic
R336	T591	T592	compound	BMP,receptor
R337	T592	T593	compound	receptor,signaling
R338	T593	T590	dobj	signaling,augment
R339	T594	T586	aux	should,investigated
R340	T595	T586	auxpass	be,investigated
R341	T596	T586	prep	as,investigated
R342	T597	T598	det	a,strategy
R343	T598	T596	pobj	strategy,as
R344	T599	T598	amod	possible,strategy
R345	T600	T598	amod	therapeutic,strategy
R346	T601	T598	prep	for,strategy
R347	T602	T601	pcomp	maintaining,for
R348	T603	T604	det	the,health
R349	T604	T602	dobj	health,maintaining
R350	T605	T604	prep	of,health
R351	T606	T607	compound	joint,linings
R352	T607	T605	pobj	linings,of
R353	T608	T586	punct	.,investigated
R360	T1083	T1084	amod	Thin,layers
R361	T1084	T1085	nsubj	layers,line
R362	T1086	T1084	prep	of,layers
R363	T1087	T1088	amod	articular,cartilage
R364	T1088	T1086	pobj	cartilage,of
R365	T1089	T1090	det	the,bones
R366	T1090	T1085	dobj	bones,line
R367	T1091	T1090	prep	of,bones
R368	T1092	T1093	amod	synovial,joints
R369	T1093	T1091	pobj	joints,of
R370	T1094	T1085	cc	and,line
R371	T1095	T1085	conj	provide,line
R372	T1096	T1097	det	a,structure
R373	T1097	T1095	dobj	structure,provide
R374	T1098	T1097	amod	smooth,structure
R375	T1099	T1097	punct	", ",structure
R376	T1100	T1101	npadvmod	wear,resistant
R377	T1101	T1097	amod	resistant,structure
R378	T1102	T1101	punct	-,resistant
R379	T1103	T1104	dep	that,reduces
R380	T1104	T1097	relcl	reduces,structure
R381	T1105	T1104	dobj	friction,reduces
R382	T1106	T1104	cc	and,reduces
R383	T1107	T1104	conj	absorbs,reduces
R384	T1108	T1109	compound	impact,forces
R385	T1109	T1107	dobj	forces,absorbs
R386	T1110	T1111	punct	(,Brandt
R387	T1111	T1095	meta	Brandt,provide
R388	T1112	T1111	nmod	et,Brandt
R389	T1113	T1111	nmod	al.,Brandt
R390	T1114	T1111	nummod	1998,Brandt
R391	T1115	T1111	punct	),Brandt
R392	T1116	T1085	punct	.,line
R393	T1118	T1119	nsubj	Loss,is
R394	T1120	T1118	cc	or,Loss
R395	T1121	T1118	conj	damage,Loss
R396	T1122	T1121	prep	to,damage
R397	T1123	T1124	amod	articular,cartilage
R398	T1124	T1122	pobj	cartilage,to
R399	T1125	T1126	det	a,hallmark
R400	T1126	T1119	attr	hallmark,is
R401	T1127	T1126	prep	of,hallmark
R402	T1128	T1129	amod	arthritic,diseases
R403	T1129	T1127	pobj	diseases,of
R404	T1130	T1119	cc	and,is
R405	T1131	T1119	conj	is,is
R406	T1132	T1131	attr	one,is
R407	T1133	T1132	prep	of,one
R408	T1134	T1135	det	the,reasons
R409	T1135	T1133	pobj	reasons,of
R410	T1136	T1137	advmod	most,common
R411	T1137	T1135	amod	common,reasons
R412	T1138	T1139	mark	that,seek
R413	T1139	T1135	acl	seek,reasons
R414	T1140	T1141	preconj	both,young
R415	T1141	T1142	amod	young,adults
R416	T1142	T1139	nsubj	adults,seek
R417	T1143	T1141	cc	and,young
R418	T1144	T1141	conj	old,young
R419	T1145	T1146	amod	medical,care
R420	T1146	T1139	dobj	care,seek
R421	T1147	T1119	punct	.,is
R422	T1149	T1150	nsubj	Millions,are
R423	T1151	T1149	prep	of,Millions
R424	T1152	T1151	pobj	people,of
R425	T1153	T1150	acomp	afflicted,are
R426	T1154	T1153	prep	with,afflicted
R427	T1155	T1154	pobj	arthritis,with
R428	T1156	T1150	punct	", ",are
R429	T1157	T1150	cc	and,are
R430	T1158	T1159	nsubj	it,affects
R431	T1159	T1150	conj	affects,are
R432	T1160	T1159	advmod	ultimately,affects
R433	T1161	T1162	amod	more,half
R434	T1162	T1159	dobj	half,affects
R435	T1163	T1162	quantmod	than,half
R436	T1164	T1162	prep	of,half
R437	T1165	T1164	pobj	people,of
R438	T1166	T1165	prep	over,people
R439	T1167	T1168	det	the,age
R440	T1168	T1166	pobj	age,over
R441	T1169	T1168	prep	of,age
R442	T1170	T1169	pobj	65,of
R443	T1171	T1172	punct	(,Badley
R444	T1172	T1159	parataxis	Badley,affects
R445	T1173	T1172	nummod	1995,Badley
R446	T1174	T1172	punct	;,Badley
R447	T1175	T1172	conj	Yelin,Badley
R448	T1176	T1175	cc	and,Yelin
R449	T1177	T1175	conj	Callahan,Yelin
R450	T1178	T1177	nummod	1995,Callahan
R451	T1179	T1172	punct	),Badley
R452	T1180	T1159	punct	.,affects
R453	T1182	T1183	det	A,understanding
R454	T1183	T1185	nsubj	understanding,is
R455	T1184	T1183	amod	better,understanding
R456	T1186	T1183	prep	of,understanding
R457	T1187	T1188	det	the,mechanisms
R458	T1188	T1186	pobj	mechanisms,of
R459	T1189	T1188	amod	molecular,mechanisms
R460	T1190	T1191	dep	that,create
R461	T1191	T1188	relcl	create,mechanisms
R462	T1192	T1191	cc	and,create
R463	T1193	T1191	conj	maintain,create
R464	T1194	T1195	amod	articular,cartilage
R465	T1195	T1193	dobj	cartilage,maintain
R466	T1196	T1185	acomp	crucial,is
R467	T1197	T1196	prep	for,crucial
R468	T1198	T1197	pcomp	discovering,for
R469	T1199	T1200	det	the,causes
R470	T1200	T1198	dobj	causes,discovering
R471	T1201	T1200	prep	of,causes
R472	T1202	T1203	compound	joint,disorders
R473	T1203	T1201	pobj	disorders,of
R474	T1204	T1198	cc	and,discovering
R475	T1205	T1198	conj	providing,discovering
R476	T1206	T1207	amod	useful,treatments
R477	T1207	T1205	dobj	treatments,providing
R478	T1208	T1207	amod	medical,treatments
R479	T1209	T1185	punct	.,is
R480	T1211	T1212	compound	Joint,formation
R481	T1212	T1213	nsubj	formation,begins
R482	T1214	T1213	prep	during,begins
R483	T1215	T1214	pobj	embryogenesis,during
R484	T1216	T1215	punct	", ",embryogenesis
R485	T1217	T1218	advmod	when,form
R486	T1218	T1215	relcl	form,embryogenesis
R487	T1219	T1218	nsubj	stripes,form
R488	T1220	T1219	prep	of,stripes
R489	T1221	T1222	amod	high,density
R490	T1222	T1220	pobj	density,of
R491	T1223	T1222	compound	cell,density
R492	T1224	T1219	acl	called,stripes
R493	T1225	T1224	oprd	interzones,called
R494	T1226	T1218	prep	across,form
R495	T1227	T1228	amod	developing,precursors
R496	T1228	T1226	pobj	precursors,across
R497	T1229	T1228	amod	skeletal,precursors
R498	T1230	T1231	punct	(,Haines
R499	T1231	T1213	meta	Haines,begins
R500	T1232	T1231	nummod	1947,Haines
R501	T1233	T1231	punct	),Haines
R502	T1234	T1213	punct	.,begins
R503	T1236	T1237	amod	Programmed,death
R504	T1237	T1239	nsubj	death,occurs
R505	T1238	T1237	compound	cell,death
R506	T1240	T1239	prep	within,occurs
R507	T1241	T1242	det	the,interzone
R508	T1242	T1240	pobj	interzone,within
R509	T1243	T1239	punct	", ",occurs
R510	T1244	T1239	cc	and,occurs
R511	T1245	T1246	det	a,interzone
R512	T1246	T1250	nsubj	interzone,forms
R513	T1247	T1248	advmod	three,layered
R514	T1248	T1246	amod	layered,interzone
R515	T1249	T1248	punct	-,layered
R516	T1250	T1239	conj	forms,occurs
R517	T1251	T1252	dep	that,has
R518	T1252	T1250	ccomp	has,forms
R519	T1253	T1254	nummod	two,layers
R520	T1254	T1252	dobj	layers,has
R521	T1255	T1254	prep	of,layers
R522	T1256	T1257	amod	higher,density
R523	T1257	T1255	pobj	density,of
R524	T1258	T1257	compound	cell,density
R525	T1259	T1254	acl	flanking,layers
R526	T1260	T1261	det	a,region
R527	T1261	T1259	dobj	region,flanking
R528	T1262	T1261	prep	of,region
R529	T1263	T1264	amod	lower,density
R530	T1264	T1262	pobj	density,of
R531	T1265	T1264	compound	cell,density
R532	T1266	T1250	punct	.,forms
R533	T1268	T1269	compound	Non-joint,precursors
R534	T1269	T1270	nsubj	precursors,develop
R535	T1271	T1269	prep	of,precursors
R536	T1272	T1273	det	the,skeleton
R537	T1273	T1271	pobj	skeleton,of
R538	T1274	T1270	advmod	typically,develop
R539	T1275	T1270	prep	into,develop
R540	T1276	T1275	pobj	cartilage,into
R541	T1277	T1276	punct	", ",cartilage
R542	T1278	T1279	dep	which,hypertrophies
R543	T1279	T1276	relcl	hypertrophies,cartilage
R544	T1280	T1279	cc	and,hypertrophies
R545	T1281	T1282	auxpass	is,replaced
R546	T1282	T1279	conj	replaced,hypertrophies
R547	T1283	T1282	agent	by,replaced
R548	T1284	T1283	pobj	bone,by
R549	T1285	T1270	punct	.,develop
R550	T1287	T1288	advmod	However,excluded
R551	T1289	T1288	punct	", ",excluded
R552	T1290	T1288	nsubjpass	cells,excluded
R553	T1291	T1290	prep	within,cells
R554	T1292	T1293	det	the,layers
R555	T1293	T1291	pobj	layers,within
R556	T1294	T1295	amod	high,density
R557	T1295	T1293	compound	density,layers
R558	T1296	T1295	punct	-,density
R559	T1297	T1293	prep	of,layers
R560	T1298	T1299	det	the,interzone
R561	T1299	T1297	pobj	interzone,of
R562	T1300	T1288	auxpass	are,excluded
R563	T1301	T1288	prep	from,excluded
R564	T1302	T1303	det	this,process
R565	T1303	T1301	pobj	process,from
R566	T1304	T1288	cc	and,excluded
R567	T1305	T1288	conj	develop,excluded
R568	T1306	T1305	prep	into,develop
R569	T1307	T1308	det	the,layers
R570	T1308	T1306	pobj	layers,into
R571	T1309	T1308	amod	permanent,layers
R572	T1310	T1308	prep	of,layers
R573	T1311	T1312	amod	articular,cartilage
R574	T1312	T1310	pobj	cartilage,of
R575	T1313	T1308	acl	found,layers
R576	T1314	T1313	prep	in,found
R577	T1315	T1316	det	the,joint
R578	T1316	T1314	pobj	joint,in
R579	T1317	T1316	amod	mature,joint
R580	T1318	T1319	punct	(,Mitrovic
R581	T1319	T1305	meta	Mitrovic,develop
R582	T1320	T1319	nummod	1978,Mitrovic
R583	T1321	T1319	punct	),Mitrovic
R584	T1322	T1288	punct	.,excluded
R585	T1324	T1325	nsubj	Studies,begun
R586	T1326	T1324	prep	over,Studies
R587	T1327	T1328	det	the,y
R588	T1328	T1326	pobj	y,over
R589	T1329	T1328	amod	last,y
R590	T1330	T1328	nummod	10,y
R591	T1331	T1325	aux	have,begun
R592	T1332	T1333	aux	to,elucidate
R593	T1333	T1325	xcomp	elucidate,begun
R594	T1334	T1333	dobj	some,elucidate
R595	T1335	T1334	prep	of,some
R596	T1336	T1337	det	the,pathways
R597	T1337	T1335	pobj	pathways,of
R598	T1338	T1337	compound	signaling,pathways
R599	T1339	T1340	dep	that,contribute
R600	T1340	T1337	relcl	contribute,pathways
R601	T1341	T1340	prep	to,contribute
R602	T1342	T1343	det	the,stages
R603	T1343	T1341	pobj	stages,to
R604	T1344	T1343	amod	early,stages
R605	T1345	T1343	prep	of,stages
R606	T1346	T1347	compound	joint,formation
R607	T1347	T1345	pobj	formation,of
R608	T1348	T1325	punct	.,begun
R609	T1350	T1351	nsubjpass	Wnt14,expressed
R610	T1352	T1351	auxpass	is,expressed
R611	T1353	T1351	prep	in,expressed
R612	T1354	T1353	pobj	stripes,in
R613	T1355	T1351	prep	at,expressed
R614	T1356	T1357	det	the,sites
R615	T1357	T1355	pobj	sites,at
R616	T1358	T1359	advmod	where,form
R617	T1359	T1357	relcl	form,sites
R618	T1360	T1359	nsubj	joints,form
R619	T1361	T1359	aux	will,form
R620	T1362	T1351	punct	", ",expressed
R621	T1363	T1351	cc	and,expressed
R622	T1364	T1365	nsubj	it,is
R623	T1365	T1351	conj	is,expressed
R624	T1366	T1365	acomp	capable,is
R625	T1367	T1366	prep	of,capable
R626	T1368	T1367	pcomp	inducing,of
R627	T1369	T1368	dobj	expression,inducing
R628	T1370	T1369	prep	of,expression
R629	T1371	T1372	amod	other,markers
R630	T1372	T1370	pobj	markers,of
R631	T1373	T1372	compound	joint,markers
R632	T1374	T1375	advmod	when,misexpressed
R633	T1375	T1365	advcl	misexpressed,is
R634	T1376	T1375	prep	at,misexpressed
R635	T1377	T1378	amod	new,locations
R636	T1378	T1376	pobj	locations,at
R637	T1379	T1378	prep	in,locations
R638	T1380	T1381	det	the,limb
R639	T1381	T1379	pobj	limb,in
R640	T1382	T1383	punct	(,Hartmann
R641	T1383	T1365	meta	Hartmann,is
R642	T1384	T1383	cc	and,Hartmann
R643	T1385	T1383	conj	Tabin,Hartmann
R644	T1386	T1385	nummod	2001,Tabin
R645	T1387	T1385	punct	),Tabin
R646	T1388	T1365	punct	.,is
R647	T1390	T1391	amod	Several,members
R648	T1391	T1392	nsubjpass	members,expressed
R649	T1393	T1391	prep	of,members
R650	T1394	T1395	det	the,family
R651	T1395	T1393	pobj	family,of
R652	T1396	T1397	nmod	bone,protein
R653	T1397	T1395	nmod	protein,family
R654	T1398	T1397	amod	morphogenetic,protein
R655	T1399	T1400	punct	(,BMP
R656	T1400	T1397	appos	BMP,protein
R657	T1401	T1400	punct	),BMP
R658	T1402	T1395	prep	of,family
R659	T1403	T1404	amod	secreted,molecules
R660	T1404	T1402	pobj	molecules,of
R661	T1405	T1404	compound	signaling,molecules
R662	T1406	T1392	auxpass	are,expressed
R663	T1407	T1392	advmod	also,expressed
R664	T1408	T1392	prep	in,expressed
R665	T1409	T1408	pobj	stripes,in
R666	T1410	T1392	prep	at,expressed
R667	T1411	T1410	pobj	sites,at
R668	T1412	T1413	advmod	where,form
R669	T1413	T1411	relcl	form,sites
R670	T1414	T1413	nsubj	joints,form
R671	T1415	T1413	aux	will,form
R672	T1416	T1411	punct	", ",sites
R673	T1417	T1411	prep	including,sites
R674	T1418	T1417	pobj	those,including
R675	T1419	T1418	acl	encoded,those
R676	T1420	T1419	agent	by,encoded
R677	T1421	T1422	det	the,genes
R678	T1422	T1420	pobj	genes,by
R679	T1423	T1422	appos	Gdf5,genes
R680	T1424	T1423	punct	", ",Gdf5
R681	T1425	T1423	conj	Gdf6,Gdf5
R682	T1426	T1425	punct	", ",Gdf6
R683	T1427	T1425	conj	Gdf7,Gdf6
R684	T1428	T1427	punct	", ",Gdf7
R685	T1429	T1427	conj	Bmp2,Gdf7
R686	T1430	T1429	punct	", ",Bmp2
R687	T1431	T1429	cc	and,Bmp2
R688	T1432	T1429	conj	Bmp4,Bmp2
R689	T1433	T1434	punct	(,Storm
R690	T1434	T1392	meta	Storm,expressed
R691	T1435	T1434	cc	and,Storm
R692	T1436	T1434	conj	Kingsley,Storm
R693	T1437	T1436	nummod	1996,Kingsley
R694	T1438	T1436	punct	;,Kingsley
R695	T1439	T1436	conj	Wolfman,Kingsley
R696	T1440	T1439	nmod	et,Wolfman
R697	T1441	T1439	nmod	al.,Wolfman
R698	T1442	T1439	nummod	1997,Wolfman
R699	T1443	T1439	punct	;,Wolfman
R700	T1444	T1439	conj	Francis,Wolfman
R701	T1445	T1444	punct	-,Francis
R702	T1446	T1444	nmod	West,Francis
R703	T1447	T1444	nmod	et,Francis
R704	T1448	T1444	nmod	al.,Francis
R705	T1449	T1444	nummod	1999,Francis
R706	T1450	T1444	punct	;,Francis
R707	T1451	T1444	conj	Settle,Francis
R708	T1452	T1451	nmod	et,Settle
R709	T1453	T1451	nmod	al.,Settle
R710	T1454	T1451	nummod	2003,Settle
R711	T1455	T1451	punct	),Settle
R712	T1456	T1392	punct	.,expressed
R713	T1458	T1459	prep	Of,is
R714	T1460	T1458	pobj	these,Of
R715	T1461	T1459	punct	", ",is
R716	T1462	T1463	compound	Gdf5,expression
R717	T1463	T1459	nsubj	expression,is
R718	T1464	T1465	advmod	most,strikingly
R719	T1465	T1466	advmod	strikingly,limited
R720	T1466	T1459	acomp	limited,is
R721	T1467	T1466	prep	to,limited
R722	T1468	T1467	pobj	regions,to
R723	T1469	T1470	advmod	where,develop
R724	T1470	T1468	relcl	develop,regions
R725	T1471	T1470	nsubj	joints,develop
R726	T1472	T1470	aux	will,develop
R727	T1473	T1459	cc	and,is
R728	T1474	T1459	conj	is,is
R729	T1475	T1474	attr	one,is
R730	T1476	T1475	prep	of,one
R731	T1477	T1478	det	the,markers
R732	T1478	T1476	pobj	markers,of
R733	T1479	T1480	amod	earliest,known
R734	T1480	T1478	amod	known,markers
R735	T1481	T1478	prep	of,markers
R736	T1482	T1483	compound	joint,formation
R737	T1483	T1481	pobj	formation,of
R738	T1484	T1459	punct	.,is
R739	T1486	T1487	nsubj	Mutations,block
R740	T1488	T1486	prep	in,Mutations
R741	T1489	T1490	preconj	either,Gdf5
R742	T1490	T1488	pobj	Gdf5,in
R743	T1491	T1490	cc	or,Gdf5
R744	T1492	T1493	det	the,gene
R745	T1493	T1490	conj	gene,Gdf5
R746	T1494	T1495	advmod	closely,related
R747	T1495	T1493	amod	related,gene
R748	T1496	T1493	compound	Gdf6,gene
R749	T1497	T1487	advmod	also,block
R750	T1498	T1487	dobj	formation,block
R751	T1499	T1498	prep	of,formation
R752	T1500	T1499	pobj	joints,of
R753	T1501	T1498	prep	at,formation
R754	T1502	T1503	amod	specific,locations
R755	T1503	T1501	pobj	locations,at
R756	T1504	T1487	punct	", ",block
R757	T1505	T1487	advcl	providing,block
R758	T1506	T1507	amod	strong,evidence
R759	T1507	T1505	dobj	evidence,providing
R760	T1508	T1509	mark	that,are
R761	T1509	T1507	acl	are,evidence
R762	T1510	T1511	det	these,molecules
R763	T1511	T1509	nsubj	molecules,are
R764	T1512	T1509	acomp	essential,are
R765	T1513	T1512	prep	for,essential
R766	T1514	T1515	det	the,process
R767	T1515	T1513	pobj	process,for
R768	T1516	T1517	compound	joint,formation
R769	T1517	T1515	compound	formation,process
R770	T1518	T1519	punct	(,Storm
R771	T1519	T1487	meta	Storm,block
R772	T1520	T1519	nmod	et,Storm
R773	T1521	T1519	nmod	al.,Storm
R774	T1522	T1519	nummod	1994,Storm
R775	T1523	T1519	punct	;,Storm
R776	T1524	T1519	nmod	Settle,Storm
R777	T1525	T1519	nmod	et,Storm
R778	T1526	T1519	nmod	al.,Storm
R779	T1527	T1519	nummod	2003,Storm
R780	T1528	T1519	punct	),Storm
R781	T1529	T1487	punct	.,block
R782	T1531	T1532	advmod	However,cause
R783	T1533	T1532	punct	", ",cause
R784	T1534	T1532	nsubj	mutations,cause
R785	T1535	T1534	prep	in,mutations
R786	T1536	T1535	pobj	Bmp2,in
R787	T1537	T1536	cc	or,Bmp2
R788	T1538	T1536	conj	Bmp4,Bmp2
R789	T1539	T1540	amod	early,lethality
R790	T1540	T1532	dobj	lethality,cause
R791	T1541	T1540	amod	embryonic,lethality
R792	T1542	T1532	punct	", ",cause
R793	T1543	T1532	advcl	making,cause
R794	T1544	T1545	nsubj	it,difficult
R795	T1545	T1543	ccomp	difficult,making
R796	T1546	T1547	aux	to,test
R797	T1547	T1545	advcl	test,difficult
R798	T1548	T1549	poss	their,role
R799	T1549	T1547	dobj	role,test
R800	T1550	T1549	prep	in,role
R801	T1551	T1552	compound	joint,formation
R802	T1552	T1550	pobj	formation,in
R803	T1553	T1554	punct	(,Winnier
R804	T1554	T1532	meta	Winnier,cause
R805	T1555	T1554	nmod	et,Winnier
R806	T1556	T1554	nmod	al.,Winnier
R807	T1557	T1554	nummod	1995,Winnier
R808	T1558	T1554	punct	;,Winnier
R809	T1559	T1554	conj	Zhang,Winnier
R810	T1560	T1559	cc	and,Zhang
R811	T1561	T1559	conj	Bradley,Zhang
R812	T1562	T1561	nummod	1996,Bradley
R813	T1563	T1561	punct	),Bradley
R814	T1564	T1532	punct	.,cause
R815	T1566	T1567	advmod	Much,less
R816	T1567	T1568	nsubjpass	less,known
R817	T1569	T1568	auxpass	is,known
R818	T1570	T1568	prep	about,known
R819	T1571	T1572	advmod	how,function
R820	T1572	T1570	pcomp	function,about
R821	T1573	T1574	compound	signaling,pathways
R822	T1574	T1572	nsubj	pathways,function
R823	T1575	T1572	prep	during,function
R824	T1576	T1577	det	the,maturation
R825	T1577	T1575	pobj	maturation,during
R826	T1578	T1577	amod	subsequent,maturation
R827	T1579	T1577	cc	and,maturation
R828	T1580	T1577	conj	maintenance,maturation
R829	T1581	T1577	prep	of,maturation
R830	T1582	T1583	compound	adult,structures
R831	T1583	T1581	pobj	structures,of
R832	T1584	T1583	compound	joint,structures
R833	T1585	T1568	punct	.,known
R834	T1587	T1588	advmod	Importantly,are
R835	T1589	T1588	punct	", ",are
R836	T1590	T1591	compound	BMP,signaling
R837	T1591	T1592	compound	signaling,components
R838	T1592	T1588	nsubj	components,are
R839	T1593	T1588	acomp	present,are
R840	T1594	T1588	prep	in,are
R841	T1595	T1596	nmod	adult,cartilage
R842	T1596	T1594	pobj	cartilage,in
R843	T1597	T1596	amod	articular,cartilage
R844	T1598	T1588	punct	", ",are
R845	T1599	T1588	advcl	suggesting,are
R846	T1600	T1601	mark	that,function
R847	T1601	T1599	ccomp	function,suggesting
R848	T1602	T1601	nsubj	they,function
R849	T1603	T1601	aux	may,function
R850	T1604	T1601	prep	during,function
R851	T1605	T1606	det	the,development
R852	T1606	T1604	pobj	development,during
R853	T1607	T1606	amod	late,development
R854	T1608	T1606	cc	or,development
R855	T1609	T1606	conj	maintenance,development
R856	T1610	T1606	prep	of,development
R857	T1611	T1612	det	this,structure
R858	T1612	T1610	pobj	structure,of
R859	T1613	T1612	amod	critical,structure
R860	T1614	T1615	punct	(,Erlacher
R861	T1615	T1588	meta	Erlacher,are
R862	T1616	T1615	nmod	et,Erlacher
R863	T1617	T1615	nmod	al.,Erlacher
R864	T1618	T1615	nummod	1998,Erlacher
R865	T1619	T1615	punct	;,Erlacher
R866	T1620	T1615	nmod	Chubinskaya,Erlacher
R867	T1621	T1615	nmod	et,Erlacher
R868	T1622	T1615	nmod	al.,Erlacher
R869	T1623	T1615	nummod	2000,Erlacher
R870	T1624	T1615	punct	;,Erlacher
R871	T1625	T1615	nmod	Muehleman,Erlacher
R872	T1626	T1615	nmod	et,Erlacher
R873	T1627	T1615	nmod	al.,Erlacher
R874	T1628	T1615	nummod	2002,Erlacher
R875	T1629	T1615	punct	;,Erlacher
R876	T1630	T1615	nmod	Bau,Erlacher
R877	T1631	T1615	nmod	et,Erlacher
R878	T1632	T1615	nmod	al.,Erlacher
R879	T1633	T1615	nummod	2002,Erlacher
R880	T1634	T1615	punct	;,Erlacher
R881	T1635	T1615	nmod	Bobacz,Erlacher
R882	T1636	T1615	nmod	et,Erlacher
R883	T1637	T1615	nmod	al.,Erlacher
R884	T1638	T1615	nummod	2003,Erlacher
R885	T1639	T1615	punct	),Erlacher
R886	T1640	T1588	punct	.,are
R887	T1642	T1643	nsubj	BMPs,bind
R888	T1644	T1645	amod	tetrameric,complexes
R889	T1645	T1643	dobj	complexes,bind
R890	T1646	T1645	prep	of,complexes
R891	T1647	T1648	nummod	two,type
R892	T1648	T1646	pobj	type,of
R893	T1649	T1648	nummod	I,type
R894	T1650	T1648	cc	and,type
R895	T1651	T1652	nummod	two,type
R896	T1652	T1653	nmod	type,receptors
R897	T1653	T1648	conj	receptors,type
R898	T1654	T1652	nummod	II,type
R899	T1655	T1653	amod	transmembrane,receptors
R900	T1656	T1657	compound	serine,threonine
R901	T1657	T1653	compound	threonine,receptors
R902	T1658	T1657	punct	-,threonine
R903	T1659	T1653	compound	kinase,receptors
R904	T1660	T1643	punct	.,bind
R905	T1662	T1663	prep	Upon,transduce
R906	T1664	T1665	compound	BMP,binding
R907	T1665	T1662	pobj	binding,Upon
R908	T1666	T1663	punct	", ",transduce
R909	T1667	T1668	det	these,complexes
R910	T1668	T1663	nsubj	complexes,transduce
R911	T1669	T1670	det	a,signal
R912	T1670	T1663	dobj	signal,transduce
R913	T1671	T1663	prep	by,transduce
R914	T1672	T1671	pcomp	phosphorylating,by
R915	T1673	T1672	dobj	members,phosphorylating
R916	T1674	T1673	prep	of,members
R917	T1675	T1676	det	the,family
R918	T1676	T1674	pobj	family,of
R919	T1677	T1676	compound	Smad,family
R920	T1678	T1676	prep	of,family
R921	T1679	T1680	compound	transcription,factors
R922	T1680	T1678	pobj	factors,of
R923	T1681	T1682	punct	(,Massague
R924	T1682	T1663	meta	Massague,transduce
R925	T1683	T1682	nummod	1996,Massague
R926	T1684	T1682	punct	),Massague
R927	T1685	T1663	punct	.,transduce
R928	T1687	T1688	amod	Recent,experiments
R929	T1688	T1689	nsubj	experiments,implicated
R930	T1690	T1689	aux	have,implicated
R931	T1691	T1692	nummod	two,receptors
R932	T1692	T1689	dative	receptors,implicated
R933	T1693	T1692	amod	different,receptors
R934	T1694	T1692	nmod	BMP,receptors
R935	T1695	T1692	nmod	type,receptors
R936	T1696	T1695	nummod	I,type
R937	T1697	T1689	prep	in,implicated
R938	T1698	T1699	amod	skeletal,patterning
R939	T1699	T1697	pobj	patterning,in
R940	T1700	T1689	punct	", ",implicated
R941	T1701	T1689	dobj	BMPR1A,implicated
R942	T1702	T1701	cc	and,BMPR1A
R943	T1703	T1701	conj	BMPR1B,BMPR1A
R944	T1704	T1689	punct	.,implicated
R945	T1706	T1707	det	Both,receptors
R946	T1707	T1708	nsubj	receptors,bind
R947	T1709	T1708	aux	can,bind
R948	T1710	T1708	dobj	BMP2,bind
R949	T1711	T1710	punct	", ",BMP2
R950	T1712	T1710	conj	BMP4,BMP2
R951	T1713	T1712	punct	", ",BMP4
R952	T1714	T1712	cc	and,BMP4
R953	T1715	T1712	conj	GDF5,BMP4
R954	T1716	T1708	punct	", ",bind
R955	T1717	T1718	mark	although,shows
R956	T1718	T1708	advcl	shows,bind
R957	T1719	T1718	nsubj	GDF5,shows
R958	T1720	T1721	amod	higher,affinity
R959	T1721	T1718	dobj	affinity,shows
R960	T1722	T1721	prep	for,affinity
R961	T1723	T1722	pobj	BMPR1B,for
R962	T1724	T1725	punct	(,Koenig
R963	T1725	T1708	meta	Koenig,bind
R964	T1726	T1725	nmod	et,Koenig
R965	T1727	T1725	nmod	al.,Koenig
R966	T1728	T1725	nummod	1994,Koenig
R967	T1729	T1725	punct	;,Koenig
R968	T1730	T1725	nmod	ten,Koenig
R969	T1731	T1725	nmod	Dijke,Koenig
R970	T1732	T1725	nmod	et,Koenig
R971	T1733	T1725	nmod	al.,Koenig
R972	T1734	T1725	nummod	1994,Koenig
R973	T1735	T1725	punct	;,Koenig
R974	T1736	T1725	nmod	Yamaji,Koenig
R975	T1737	T1725	nmod	et,Koenig
R976	T1738	T1725	nmod	al.,Koenig
R977	T1739	T1725	nummod	1994,Koenig
R978	T1740	T1725	punct	;,Koenig
R979	T1741	T1725	nmod	Nishitoh,Koenig
R980	T1742	T1725	nmod	et,Koenig
R981	T1743	T1725	nmod	al.,Koenig
R982	T1744	T1725	nummod	1996,Koenig
R983	T1745	T1725	punct	;,Koenig
R984	T1746	T1725	nmod	Chalaux,Koenig
R985	T1747	T1725	nmod	et,Koenig
R986	T1748	T1725	nmod	al.,Koenig
R987	T1749	T1725	nummod	1998,Koenig
R988	T1750	T1725	punct	),Koenig
R989	T1751	T1708	punct	.,bind
R990	T1753	T1754	det	Both,receptors
R991	T1754	T1755	nsubjpass	receptors,expressed
R992	T1756	T1755	auxpass	are,expressed
R993	T1757	T1755	advmod	also,expressed
R994	T1758	T1755	prep	in,expressed
R995	T1759	T1760	amod	dynamic,patterns
R996	T1760	T1758	pobj	patterns,in
R997	T1802	T1801	amod	precartilaginous,cells
R998	T1761	T1755	prep	during,expressed
R999	T1803	T1801	amod	mesenchymal,cells
R1000	T1762	T1763	amod	normal,development
R1001	T1804	T1801	punct	", ",cells
R1002	T1805	T1801	appos	regions,cells
R1003	T1763	T1761	pobj	development,during
R1004	T1806	T1805	acl	flanking,regions
R1005	T1807	T1808	compound	joint,interzones
R1006	T1764	T1755	punct	.,expressed
R1007	T1808	T1806	dobj	interzones,flanking
R1008	T1809	T1808	punct	", ",interzones
R1009	T1810	T1808	conj	perichondrium,interzones
R1010	T1766	T1767	prep	In,becomes
R1011	T1811	T1810	punct	", ",perichondrium
R1012	T1812	T1810	cc	and,perichondrium
R1013	T1813	T1814	amod	periarticular,cartilage
R1014	T1814	T1810	conj	cartilage,perichondrium
R1015	T1768	T1766	pobj	limbs,In
R1016	T1815	T1816	punct	(,Dewulf
R1017	T1816	T1792	meta	Dewulf,seen
R1018	T1817	T1816	nmod	et,Dewulf
R1019	T1818	T1816	nmod	al.,Dewulf
R1020	T1769	T1767	punct	", ",becomes
R1021	T1819	T1816	nummod	1995,Dewulf
R1022	T1820	T1816	punct	;,Dewulf
R1023	T1770	T1771	compound	Bmpr1a,expression
R1024	T1821	T1816	nmod	Mishina,Dewulf
R1025	T1822	T1816	nmod	et,Dewulf
R1026	T1823	T1816	nmod	al.,Dewulf
R1027	T1771	T1767	nsubj	expression,becomes
R1028	T1824	T1816	nummod	1995,Dewulf
R1029	T1825	T1816	punct	;,Dewulf
R1030	T1826	T1816	nmod	Zou,Dewulf
R1031	T1772	T1767	oprd	restricted,becomes
R1032	T1827	T1816	nmod	et,Dewulf
R1033	T1828	T1816	nmod	al.,Dewulf
R1034	T1829	T1816	nummod	1997,Dewulf
R1035	T1830	T1816	punct	;,Dewulf
R1036	T1831	T1816	nmod	Baur,Dewulf
R1037	T1773	T1772	prep	to,restricted
R1038	T1832	T1816	nmod	et,Dewulf
R1039	T1833	T1816	nmod	al.,Dewulf
R1040	T1834	T1816	nummod	2000,Dewulf
R1041	T1774	T1775	compound	joint,interzones
R1042	T1835	T1816	punct	),Dewulf
R1043	T1836	T1792	punct	.,seen
R1044	T1775	T1773	pobj	interzones,to
R1045	T1838	T1839	amod	Null,mutations
R1046	T1839	T1840	nsubj	mutations,produce
R1047	T1776	T1775	punct	", ",interzones
R1048	T1841	T1839	prep	in,mutations
R1049	T1842	T1843	det	the,gene
R1050	T1777	T1775	conj	perichondrium,interzones
R1051	T1843	T1841	pobj	gene,in
R1052	T1844	T1843	compound	Bmpr1b,gene
R1053	T1845	T1846	amod	viable,mice
R1054	T1778	T1777	punct	", ",perichondrium
R1055	T1846	T1840	dobj	mice,produce
R1056	T1847	T1846	prep	with,mice
R1057	T1779	T1780	amod	periarticular,cartilage
R1058	T1848	T1847	pobj	defects,with
R1059	T1849	T1848	prep	in,defects
R1060	T1850	T1851	nmod	bone,formation
R1061	T1780	T1777	conj	cartilage,perichondrium
R1062	T1851	T1849	pobj	formation,in
R1063	T1852	T1850	cc	and,bone
R1064	T1853	T1850	conj	joint,bone
R1065	T1781	T1780	punct	", ",cartilage
R1066	T1854	T1855	dep	that,resemble
R1067	T1855	T1848	relcl	resemble,defects
R1068	T1856	T1855	advmod	closely,resemble
R1069	T1782	T1783	amod	hypertrophic,chondrocytes
R1070	T1857	T1855	dobj	those,resemble
R1071	T1858	T1857	acl	seen,those
R1072	T1783	T1780	conj	chondrocytes,cartilage
R1073	T1859	T1858	prep	in,seen
R1074	T1860	T1859	pobj	mice,in
R1075	T1861	T1860	acl	missing,mice
R1076	T1784	T1783	punct	", ",chondrocytes
R1077	T1862	T1861	dobj	Gdf5,missing
R1078	T1863	T1864	punct	(,Storm
R1079	T1785	T1783	cc	and,chondrocytes
R1083	T1786	T1787	amod	interdigital,mesenchyme
R1084	T1867	T1866	nummod	1996,Kingsley
R1085	T1868	T1866	punct	;,Kingsley
R1086	T1869	T1866	conj	Baur,Kingsley
R1087	T1870	T1869	nmod	et,Baur
R1088	T1871	T1869	nmod	al.,Baur
R1089	T1787	T1783	conj	mesenchyme,chondrocytes
R1090	T1872	T1869	nummod	2000,Baur
R1091	T1873	T1869	punct	;,Baur
R1092	T1874	T1869	conj	Yi,Baur
R1093	T1788	T1787	compound	limb,mesenchyme
R1094	T1875	T1874	nmod	et,Yi
R1095	T1789	T1767	punct	.,becomes
R1096	T1876	T1874	nmod	al.,Yi
R1097	T1877	T1874	nummod	2000,Yi
R1098	T1791	T1792	prep	In,seen
R1099	T1878	T1874	punct	),Yi
R1100	T1879	T1840	punct	.,produce
R1101	T1793	T1791	pobj	comparison,In
R1102	T1881	T1882	amod	Null,mutations
R1103	T1882	T1883	nsubj	mutations,cause
R1104	T1884	T1882	prep	in,mutations
R1105	T1794	T1792	punct	", ",seen
R1106	T1885	T1884	pobj	Bmpr1a,in
R1107	T1886	T1887	amod	early,lethality
R1108	T1795	T1796	compound	Bmpr1b,expression
R1109	T1887	T1883	dobj	lethality,cause
R1110	T1888	T1887	amod	embryonic,lethality
R1111	T1889	T1883	punct	", ",cause
R1112	T1796	T1792	nsubjpass	expression,seen
R1113	T1890	T1891	mark	with,similar
R1114	T1891	T1883	advcl	similar,cause
R1115	T1892	T1891	nsubj	defects,similar
R1116	T1797	T1792	auxpass	is,seen
R1117	T1893	T1892	prep	in,defects
R1118	T1894	T1893	pobj	gastrulation,in
R1119	T1895	T1891	prep	to,similar
R1120	T1798	T1792	advmod	primarily,seen
R1121	T1896	T1895	pobj	those,to
R1122	T1897	T1896	acl	seen,those
R1123	T1799	T1792	prep	in,seen
R1124	T1898	T1897	prep	in,seen
R1125	T1899	T1898	pobj	mice,in
R1126	T1900	T1899	prep	with,mice
R1127	T1800	T1801	amod	condensing,cells
R1128	T1901	T1900	pobj	mutations,with
R1129	T1902	T1901	prep	in,mutations
R1130	T1903	T1902	pobj	Bmp4,in
R1131	T1801	T1799	pobj	cells,in
R1132	T1904	T1905	punct	(,Mishina
R1133	T1905	T1883	meta	Mishina,cause
R1134	T1906	T1905	nmod	et,Mishina
R1135	T1908	T1905	nummod	1995,Mishina
R1136	T1907	T1905	nmod	al.,Mishina
R1137	T1909	T1905	punct	;,Mishina
R1138	T1910	T1905	nmod	Winnier,Mishina
R1139	T1911	T1905	nmod	et,Mishina
R1140	T2014	T2015	aux	to,remove
R1141	T2015	T2011	advcl	remove,used
R1142	T1912	T1905	nmod	al.,Mishina
R1143	T2016	T2015	cc	or,remove
R1144	T2017	T2018	advmod	ectopically,express
R1145	T2018	T2015	conj	express,remove
R1146	T1913	T1905	nummod	1995,Mishina
R1147	T2019	T2018	dobj	genes,express
R1148	T2020	T2019	prep	in,genes
R1149	T1914	T1905	punct	),Mishina
R1150	T2021	T2020	pobj	joints,in
R1151	T2022	T1980	punct	.,take
R1152	T1915	T1883	punct	.,cause
R1153	T2024	T2025	nsubj	Tests,show
R1154	T1917	T1918	amod	Recent,studies
R1155	T2026	T2024	prep	with,Tests
R1156	T2027	T2028	compound	reporter,mice
R1157	T2028	T2026	pobj	mice,with
R1158	T1918	T1919	nsubj	studies,suggest
R1159	T2029	T2030	mark	that,is
R1160	T2030	T2025	ccomp	is,show
R1161	T2031	T2032	det	this,system
R1162	T1920	T1918	prep	with,studies
R1163	T2032	T2030	nsubj	system,is
R1164	T2033	T2030	acomp	capable,is
R1165	T2034	T2033	prep	of,capable
R1166	T2035	T2034	pcomp	modifying,of
R1167	T2036	T2035	dobj	genes,modifying
R1168	T1921	T1922	amod	floxed,alleles
R1169	T2037	T2035	prep	in,modifying
R1170	T2038	T2037	pobj	all,in
R1171	T1922	T1920	pobj	alleles,with
R1172	T2039	T2038	prep	of,all
R1173	T2040	T2041	det	the,structures
R1174	T2041	T2039	pobj	structures,of
R1175	T1923	T1924	mark	that,required
R1176	T2042	T2041	prep	of,structures
R1177	T2043	T2044	det	the,joint
R1178	T2044	T2042	pobj	joint,of
R1179	T1924	T1919	ccomp	required,suggest
R1180	T2045	T2044	amod	mature,joint
R1181	T2046	T2044	amod	synovial,joint
R1182	T1925	T1924	nsubjpass	Bmpr1a,required
R1183	T2047	T2038	punct	", ",all
R1184	T1926	T1924	auxpass	is,required
R1185	T2048	T2038	prep	including,all
R1186	T1927	T1924	advmod	also,required
R1187	T2049	T2050	det	the,ligaments
R1188	T2050	T2048	pobj	ligaments,including
R1189	T2051	T2050	prep	of,ligaments
R1190	T2052	T2053	det	the,capsule
R1191	T1928	T1924	prep	for,required
R1192	T1929	T1930	amod	many,events
R1193	T2053	T2051	pobj	capsule,of
R1194	T2054	T2053	compound	joint,capsule
R1195	T1930	T1928	pobj	events,for
R1196	T2055	T2050	punct	", ",ligaments
R1197	T2056	T2057	det	the,membrane
R1198	T1931	T1930	amod	later,events
R1199	T2057	T2050	conj	membrane,ligaments
R1200	T2058	T2057	amod	synovial,membrane
R1201	T1932	T1930	amod	developmental,events
R1202	T2059	T2057	punct	", ",membrane
R1203	T2060	T2057	cc	and,membrane
R1204	T2061	T2062	det	the,cartilage
R1205	T1933	T1919	punct	", ",suggest
R1206	T2062	T2057	conj	cartilage,membrane
R1207	T2063	T2062	amod	articular,cartilage
R1208	T1934	T1919	cc	but,suggest
R1209	T2064	T2025	punct	.,show
R1210	T2066	T2067	compound	Gdf5,Cre
R1211	T1935	T1936	poss	its,roles
R1212	T2067	T2069	compound	Cre,recombination
R1213	T2068	T2067	punct	-,Cre
R1214	T2069	T2070	nsubj	recombination,bypasses
R1215	T1936	T1937	nsubjpass	roles,tested
R1216	T2071	T2072	det	the,lethality
R1217	T1937	T1919	conj	tested,suggest
R1218	T2072	T2070	dobj	lethality,bypasses
R1219	T2073	T2074	amod	early,embryonic
R1220	T2074	T2072	amod	embryonic,lethality
R1221	T1938	T1936	prep	in,roles
R1222	T2075	T2072	prep	of,lethality
R1223	T2076	T2077	amod	null,mutations
R1224	T1939	T1940	nmod	bone,formation
R1225	T2077	T2075	pobj	mutations,of
R1226	T2078	T2070	prep	in,bypasses
R1227	T2079	T2078	pobj	Bmpr1a,in
R1228	T1940	T1938	pobj	formation,in
R1229	T2080	T2070	punct	", ",bypasses
R1230	T2081	T2070	cc	and,bypasses
R1231	T2082	T2070	conj	shows,bypasses
R1232	T1941	T1939	cc	and,bone
R1233	T2083	T2084	mark	that,required
R1234	T2084	T2082	ccomp	required,shows
R1235	T1942	T1939	conj	joint,bone
R1236	T2085	T2086	det	this,receptor
R1237	T2086	T2084	nsubjpass	receptor,required
R1238	T2087	T2084	auxpass	is,required
R1239	T1943	T1937	aux	have,tested
R1240	T2088	T2084	prep	for,required
R1241	T2089	T2090	amod	early,formation
R1242	T2090	T2088	pobj	formation,for
R1243	T2091	T2090	compound	joint,formation
R1244	T2092	T2090	prep	at,formation
R1245	T2093	T2094	det	some,locations
R1246	T1944	T1937	neg	not,tested
R1247	T2094	T2092	pobj	locations,at
R1248	T2095	T2088	cc	and,for
R1249	T2096	T2088	conj	for,for
R1250	T1945	T1937	advmod	yet,tested
R1251	T2097	T2096	pobj	initiation,for
R1252	T2098	T2097	prep	of,initiation
R1253	T2099	T2100	amod	programmed,death
R1254	T2100	T2098	pobj	death,of
R1255	T1946	T1937	auxpass	been,tested
R1256	T2101	T2100	compound	cell,death
R1257	T2102	T2100	prep	in,death
R1258	T1947	T1948	punct	(,Mishina
R1259	T2103	T2102	pobj	webbing,in
R1260	T1948	T1937	meta	Mishina,tested
R1261	T2104	T2103	prep	between,webbing
R1262	T2105	T2104	pobj	digits,between
R1263	T2106	T2070	punct	.,bypasses
R1264	T1949	T1948	nummod	2003,Mishina
R1265	T2108	T2109	advmod	Interestingly,is
R1266	T1950	T1948	punct	),Mishina
R1267	T2110	T2109	punct	", ",is
R1268	T2111	T2109	nsubj	Bmpr1a,is
R1269	T2112	T2109	advmod	also,is
R1270	T1951	T1937	punct	.,tested
R1271	T2113	T2109	acomp	required,is
R1272	T2114	T2109	prep	for,is
R1273	T2115	T2116	amod	postnatal,maintenance
R1274	T1953	T1954	det	A,system
R1275	T2116	T2114	pobj	maintenance,for
R1276	T2117	T2116	prep	of,maintenance
R1277	T2118	T2119	amod	articular,cartilage
R1278	T2119	T2117	pobj	cartilage,of
R1279	T1954	T1956	nsubj	system,be
R1280	T2120	T2109	prep	throughout,is
R1281	T1955	T1954	amod	genetic,system
R1282	T1957	T1954	prep	for,system
R1283	T2121	T2120	pobj	most,throughout
R1284	T1958	T1957	pcomp	activating,for
R1285	T2122	T2121	prep	of,most
R1286	T2123	T2124	det	the,skeleton
R1287	T2124	T2122	pobj	skeleton,of
R1288	T1959	T1958	cc	or,activating
R1289	T2125	T2109	punct	.,is
R1290	T2127	T2128	prep	In,forms
R1291	T1960	T1958	conj	inactivating,activating
R1292	T2129	T2130	nmod	Gdf5,Cre
R1293	T2130	T2132	nmod	Cre,mice
R1294	T2131	T2130	punct	-,Cre
R1295	T2132	T2127	pobj	mice,In
R1296	T2133	T2130	punct	/,Cre
R1297	T1961	T1960	dobj	genes,inactivating
R1298	T2134	T2130	appos	Bmpr1afloxP,Cre
R1299	T1962	T1963	advmod	specifically,in
R1300	T2135	T2128	punct	", ",forms
R1301	T2136	T2137	amod	articular,cartilage
R1302	T1963	T1960	prep	in,inactivating
R1303	T2137	T2128	nsubj	cartilage,forms
R1304	T2138	T2128	advmod	initially,forms
R1305	T2139	T2128	advmod	normally,forms
R1306	T1964	T1965	compound	joint,tissues
R1307	T2140	T2128	punct	", ",forms
R1308	T2141	T2128	cc	but,forms
R1309	T1965	T1963	pobj	tissues,in
R1310	T2142	T2143	advmod	subsequently,loses
R1311	T2143	T2128	conj	loses,forms
R1312	T1966	T1956	aux	would,be
R1313	T2144	T2143	dobj	expression,loses
R1314	T2145	T2144	prep	of,expression
R1315	T2146	T2147	amod	several,markers
R1316	T1967	T1968	advmod	particularly,useful
R1317	T2147	T2145	pobj	markers,of
R1318	T2148	T2147	amod	key,markers
R1319	T1968	T1956	acomp	useful,be
R1320	T2149	T2147	compound	cartilage,markers
R1321	T2150	T2143	prep	after,loses
R1322	T2151	T2150	pobj	birth,after
R1323	T1969	T1968	prep	for,useful
R1324	T2152	T2128	punct	.,forms
R1325	T1970	T1971	amod	further,studies
R1326	T2154	T2155	nsubj	It,fibrillates
R1327	T1971	T1969	pobj	studies,for
R1328	T2156	T2155	advmod	ultimately,fibrillates
R1329	T2157	T2155	cc	and,fibrillates
R1330	T2158	T2155	conj	degenerates,fibrillates
R1331	T1972	T1971	prep	of,studies
R1332	T2159	T2158	punct	", ",degenerates
R1333	T2160	T2158	conj	resulting,degenerates
R1334	T2161	T2160	prep	in,resulting
R1335	T1973	T1974	compound	joint,formation
R1336	T2162	T2163	amod	severe,osteoarthritis
R1337	T2163	T2161	pobj	osteoarthritis,in
R1338	T2164	T2163	cc	and,osteoarthritis
R1339	T1974	T1972	pobj	formation,of
R1340	T2165	T2163	conj	loss,osteoarthritis
R1341	T2166	T2165	prep	of,loss
R1342	T1975	T1974	cc	and,formation
R1343	T2167	T2166	pobj	mobility,of
R1344	T2168	T2155	punct	.,fibrillates
R1345	T2170	T2171	det	These,experiments
R1346	T2171	T2172	nsubj	experiments,suggest
R1347	T1976	T1974	conj	maintenance,formation
R1348	T2173	T2174	mark	that,required
R1349	T2174	T2172	advcl	required,suggest
R1350	T1977	T1956	punct	.,be
R1351	T2175	T2176	compound	BMP,signaling
R1352	T2176	T2174	nsubjpass	signaling,required
R1353	T2177	T2174	auxpass	is,required
R1354	T1979	T1980	advmod	Here,take
R1355	T2178	T2174	prep	for,required
R1356	T2179	T2180	amod	normal,maintenance
R1357	T2180	T2178	pobj	maintenance,for
R1358	T2181	T2180	prep	of,maintenance
R1359	T1981	T1980	nsubj	we,take
R1360	T2182	T2183	amod	postnatal,cartilage
R1361	T2183	T2181	pobj	cartilage,of
R1362	T2184	T2183	amod	articular,cartilage
R1363	T1982	T1980	dobj	advantage,take
R1364	T2185	T2174	punct	", ",required
R1365	T2186	T2174	cc	and,required
R1366	T2187	T2188	mark	that,play
R1367	T1983	T1980	prep	of,take
R1368	T2188	T2174	conj	play,required
R1369	T2189	T2188	nsubj	modulation,play
R1370	T1984	T1985	det	the,pattern
R1371	T2190	T2189	prep	of,modulation
R1372	T2191	T2192	det	the,pathway
R1373	T2192	T2190	pobj	pathway,of
R1374	T1985	T1983	pobj	pattern,of
R1375	T2193	T2194	compound	BMP,signaling
R1376	T2194	T2192	compound	signaling,pathway
R1377	T2195	T2188	aux	may,play
R1378	T1986	T1987	npadvmod	tissue,specific
R1379	T2196	T2197	det	an,role
R1380	T2197	T2188	dobj	role,play
R1381	T2198	T2197	amod	important,role
R1382	T2199	T2188	prep	in,play
R1383	T1987	T1985	amod	specific,pattern
R1384	T2200	T2201	compound	joint,disease
R1385	T2201	T2199	pobj	disease,in
R1386	T1988	T1987	punct	-,specific
R1387	T2202	T2172	punct	.,suggest
R1388	T1989	T1985	compound	expression,pattern
R1389	T1990	T1985	prep	of,pattern
R1390	T1991	T1992	det	the,gene
R1391	T1992	T1990	pobj	gene,of
R1392	T1993	T1992	compound	Gdf5,gene
R1393	T1994	T1995	aux	to,engineer
R1394	T1995	T1980	advcl	engineer,take
R1395	T1996	T1997	det	a,system
R1396	T1997	T1995	dobj	system,engineer
R1397	T1998	T1999	compound	Cre,loxP
R1398	T1999	T1997	compound	loxP,system
R1399	T2000	T1999	punct	/,loxP
R1400	T2001	T2002	punct	(,Nagy
R1401	T2002	T1997	meta	Nagy,system
R1402	T2003	T2002	nummod	2000,Nagy
R1403	T2004	T2002	punct	),Nagy
R1404	T2005	T1997	punct	", ",system
R1405	T2006	T2007	compound	Gdf5,Cre
R1406	T2007	T1997	appos	Cre,system
R1407	T2008	T2007	punct	-,Cre
R1408	T2009	T1997	punct	", ",system
R1409	T2010	T2011	dep	that,used
R1410	T2011	T1997	relcl	used,system
R1411	T2012	T2011	aux	can,used
R1412	T2013	T2011	auxpass	be,used
R1427	T2682	T2683	amod	Genetic,System
R1428	T2684	T2683	prep	for,System
R1429	T2685	T2684	pcomp	Testing,for
R1430	T2686	T2687	det	the,Function
R1431	T2687	T2685	dobj	Function,Testing
R1432	T2688	T2687	prep	of,Function
R1433	T2689	T2688	pobj	Genes,of
R1434	T2690	T2687	prep	in,Function
R1435	T2691	T2692	compound	Joint,Development
R1436	T2692	T2690	pobj	Development,in
R1437	T2694	T2695	aux	To,generate
R1438	T2695	T2696	advcl	generate,engineered
R1439	T2697	T2698	det	a,system
R1440	T2698	T2695	dobj	system,generate
R1441	T2699	T2698	amod	general,system
R1442	T2700	T2698	amod	capable,system
R1443	T2701	T2700	prep	of,capable
R1444	T2702	T2703	advmod	specifically,testing
R1445	T2703	T2701	pcomp	testing,of
R1446	T2704	T2703	dobj	genes,testing
R1447	T2705	T2703	prep	for,testing
R1448	T2706	T2705	pobj	functions,for
R1449	T2707	T2706	prep	in,functions
R1450	T2708	T2709	amod	skeletal,development
R1451	T2709	T2707	pobj	development,in
R1452	T2710	T2709	compound	joint,development
R1453	T2711	T2696	punct	", ",engineered
R1454	T2712	T2696	nsubj	we,engineered
R1455	T2713	T2714	amod	transgenic,mice
R1456	T2714	T2696	dobj	mice,engineered
R1457	T2715	T2716	aux	to,express
R1458	T2716	T2696	xcomp	express,engineered
R1459	T2717	T2718	compound	Cre,recombinase
R1460	T2718	T2716	dobj	recombinase,express
R1461	T2719	T2716	prep	in,express
R1462	T2720	T2721	amod	developing,joints
R1463	T2721	T2719	pobj	joints,in
R1464	T2722	T2723	punct	(,Figure
R1465	T2723	T2696	parataxis	Figure,engineered
R1466	T2724	T2723	nummod	1,Figure
R1467	T2725	T2723	punct	),Figure
R1468	T2726	T2696	punct	.,engineered
R1469	T2728	T2729	nsubj	Gdf5,is
R1470	T2730	T2731	det	a,gene
R1471	T2731	T2729	attr	gene,is
R1472	T2732	T2733	advmod	strongly,expressed
R1473	T2733	T2731	acl	expressed,gene
R1474	T2734	T2733	prep	in,expressed
R1475	T2735	T2734	pobj	stripes,in
R1476	T2736	T2733	prep	across,expressed
R1477	T2737	T2738	amod	developing,elements
R1478	T2738	T2736	pobj	elements,across
R1479	T2739	T2738	amod	skeletal,elements
R1480	T2740	T2733	prep	during,expressed
R1481	T2741	T2742	amod	embryonic,formation
R1482	T2742	T2740	pobj	formation,during
R1483	T2743	T2742	compound	joint,formation
R1484	T2744	T2729	punct	.,is
R1485	T2746	T2747	det	A,chromosome
R1486	T2747	T2750	nsubjpass	chromosome,modified
R1487	T2748	T2749	amod	bacterial,artificial
R1488	T2749	T2747	amod	artificial,chromosome
R1489	T2751	T2747	punct	(,chromosome
R1490	T2752	T2747	appos	BAC,chromosome
R1491	T2753	T2747	punct	),chromosome
R1492	T2754	T2747	acl	containing,chromosome
R1493	T2755	T2756	det	the,locus
R1494	T2756	T2754	dobj	locus,containing
R1495	T2757	T2756	compound	Gdf5,locus
R1496	T2758	T2750	auxpass	was,modified
R1497	T2759	T2750	prep	by,modified
R1498	T2760	T2761	amod	homologous,recombination
R1499	T2761	T2759	pobj	recombination,by
R1500	T2762	T2750	prep	in,modified
R1501	T2763	T2762	pobj	bacteria,in
R1502	T2764	T2765	aux	to,insert
R1503	T2765	T2750	advcl	insert,modified
R1504	T2766	T2767	det	a,cassette
R1505	T2767	T2765	dobj	cassette,insert
R1506	T2768	T2767	acl	encoding,cassette
R1507	T2769	T2770	nmod	Cre,phosphatase
R1508	T2770	T2768	dobj	phosphatase,encoding
R1509	T2771	T2770	punct	-,phosphatase
R1510	T2772	T2773	amod	internal,entry
R1511	T2773	T2775	nmod	entry,site
R1512	T2774	T2773	nmod	ribosome,entry
R1513	T2775	T2770	nmod	site,phosphatase
R1514	T2776	T2775	punct	(,site
R1515	T2777	T2775	appos	IRES,site
R1516	T2778	T2775	punct	),site
R1517	T2779	T2770	punct	-,phosphatase
R1518	T2780	T2781	amod	human,placental
R1519	T2781	T2770	amod	placental,phosphatase
R1520	T2782	T2770	compound	alkaline,phosphatase
R1521	T2783	T2770	punct	(,phosphatase
R1522	T2784	T2770	appos	hPLAP,phosphatase
R1523	T2785	T2770	punct	),phosphatase
R1524	T2786	T2765	prep	into,insert
R1525	T2787	T2788	det	the,site
R1526	T2788	T2786	pobj	site,into
R1527	T2789	T2788	compound	translation,site
R1528	T2790	T2788	compound	start,site
R1529	T2791	T2788	prep	of,site
R1530	T2792	T2791	pobj	Gdf5,of
R1531	T2793	T2794	punct	(,Figure
R1532	T2794	T2765	parataxis	Figure,insert
R1533	T2795	T2794	nummod	1A,Figure
R1534	T2796	T2794	punct	),Figure
R1535	T2797	T2750	punct	.,modified
R1536	T2799	T2800	det	This,BAC
R1537	T2800	T2802	nsubjpass	BAC,used
R1538	T2801	T2800	amod	modified,BAC
R1539	T2803	T2802	auxpass	was,used
R1540	T2804	T2802	advmod	then,used
R1541	T2805	T2806	aux	to,make
R1542	T2806	T2802	advcl	make,used
R1543	T2807	T2806	dobj	lines,make
R1544	T2808	T2807	prep	of,lines
R1545	T2809	T2810	amod	transgenic,mice
R1546	T2810	T2808	pobj	mice,of
R1547	T2811	T2802	punct	.,used
R1548	T2813	T2814	det	The,mice
R1549	T2814	T2820	nsubjpass	mice,tested
R1550	T2815	T2814	amod	resulting,mice
R1551	T2816	T2817	nmod	Gdf5,Cre
R1552	T2817	T2814	nmod	Cre,mice
R1553	T2818	T2817	punct	-,Cre
R1554	T2819	T2814	amod	transgenic,mice
R1555	T2821	T2820	auxpass	were,tested
R1556	T2822	T2820	prep	for,tested
R1557	T2823	T2824	compound	transgene,expression
R1558	T2824	T2822	pobj	expression,for
R1559	T2825	T2824	cc	and,expression
R1560	T2826	T2827	compound	Cre,recombinase
R1561	T2827	T2828	compound	recombinase,activity
R1562	T2828	T2824	conj	activity,expression
R1563	T2829	T2820	prep	by,tested
R1564	T2830	T2829	pcomp	crossing,by
R1565	T2831	T2830	dobj	them,crossing
R1566	T2832	T2830	prep	to,crossing
R1567	T2833	T2834	compound	R26R,reporter
R1568	T2834	T2835	compound	reporter,mice
R1569	T2835	T2832	pobj	mice,to
R1570	T2836	T2837	dep	that,activate
R1571	T2837	T2835	relcl	activate,mice
R1572	T2838	T2839	det	the,expression
R1573	T2839	T2837	dobj	expression,activate
R1574	T2840	T2839	prep	of,expression
R1575	T2841	T2840	pobj	lacZ,of
R1576	T2842	T2837	prep	after,activate
R1577	T2843	T2844	npadvmod	Cre,mediated
R1578	T2844	T2846	amod	mediated,removal
R1579	T2845	T2844	punct	-,mediated
R1580	T2846	T2842	pobj	removal,after
R1581	T2847	T2846	prep	of,removal
R1582	T2848	T2849	amod	transcriptional,sequences
R1583	T2849	T2847	pobj	sequences,of
R1584	T2850	T2849	compound	stop,sequences
R1585	T2851	T2852	punct	(,Soriano
R1586	T2852	T2820	meta	Soriano,tested
R1587	T2853	T2852	nummod	1999,Soriano
R1588	T2854	T2852	punct	),Soriano
R1589	T2855	T2820	punct	.,tested
R1590	T2857	T2858	det	The,progeny
R1591	T2858	T2860	nsubjpass	progeny,analyzed
R1592	T2859	T2858	amod	resulting,progeny
R1593	T2861	T2860	auxpass	were,analyzed
R1594	T2862	T2860	preconj	both,analyzed
R1595	T2863	T2860	conj	for,analyzed
R1596	T2864	T2863	pobj	expression,for
R1597	T2865	T2864	prep	of,expression
R1598	T2866	T2867	det	the,transgene
R1599	T2867	T2865	pobj	transgene,of
R1600	T2868	T2863	prep	by,for
R1601	T2869	T2868	pcomp	assaying,by
R1602	T2870	T2871	compound	HPLAP,activity
R1603	T2871	T2869	dobj	activity,assaying
R1604	T2872	T2860	cc	and,analyzed
R1605	T2873	T2860	conj	for,analyzed
R1606	T2874	T2873	pobj	recombination,for
R1607	T2875	T2874	prep	of,recombination
R1608	T2876	T2875	pobj	DNA,of
R1609	T2877	T2873	prep	by,for
R1610	T2878	T2877	pcomp	assaying,by
R1611	T2879	T2880	compound	LACZ,activity
R1612	T2880	T2878	dobj	activity,assaying
R1613	T2881	T2860	punct	.,analyzed
R1614	T2883	T2884	det	The,progeny
R1615	T2884	T2885	nsubj	progeny,showed
R1616	T2886	T2884	prep	from,progeny
R1617	T2887	T2888	det	all,lines
R1618	T2888	T2886	pobj	lines,from
R1619	T2889	T2888	nummod	three,lines
R1620	T2890	T2891	amod	strong,expression
R1621	T2891	T2885	dobj	expression,showed
R1622	T2892	T2891	compound	LACZ,expression
R1623	T2893	T2894	advmod	primarily,in
R1624	T2894	T2885	prep	in,showed
R1625	T2895	T2894	pobj	joints,in
R1626	T2896	T2885	punct	", ",showed
R1627	T2897	T2885	cc	and,showed
R1628	T2898	T2899	prep	in,seen
R1629	T2899	T2885	conj	seen,showed
R1630	T2900	T2901	quantmod	two,three
R1631	T2901	T2903	nummod	three,lines
R1632	T2902	T2901	quantmod	of,three
R1633	T2903	T2898	pobj	lines,in
R1634	T2904	T2905	compound	HPLAP,expression
R1635	T2905	T2899	nsubjpass	expression,seen
R1636	T2906	T2899	aux	could,seen
R1637	T2907	T2899	advmod	also,seen
R1638	T2908	T2899	auxpass	be,seen
R1639	T2909	T2899	prep	in,seen
R1640	T2910	T2911	compound	joint,regions
R1641	T2911	T2909	pobj	regions,in
R1642	T2912	T2899	punct	.,seen
R1643	T2914	T2915	advmod	Interestingly,seen
R1644	T2916	T2915	punct	", ",seen
R1645	T2917	T2918	compound	HPLAP,expression
R1646	T2918	T2915	nsubjpass	expression,seen
R1647	T2919	T2918	prep	in,expression
R1648	T2920	T2921	det	the,line
R1649	T2921	T2919	pobj	line,in
R1650	T2922	T2923	nmod	Gdf5,Cre
R1651	T2923	T2921	nmod	Cre,line
R1652	T2924	T2923	punct	-,Cre
R1653	T2925	T2923	amod	transgenic,Cre
R1654	T2926	T2927	nmod	GAC,A
R1655	T2927	T2923	appos	A,Cre
R1656	T2928	T2927	punct	(,A
R1657	T2929	T2927	punct	),A
R1658	T2930	T2921	acl	used,line
R1659	T2931	T2930	prep	for,used
R1660	T2932	T2933	det	all,experiments
R1661	T2933	T2931	pobj	experiments,for
R1662	T2934	T2933	amod	subsequent,experiments
R1663	T2935	T2933	compound	breeding,experiments
R1664	T2936	T2915	auxpass	was,seen
R1665	T2937	T2938	aux	to,precede
R1666	T2938	T2915	xcomp	precede,seen
R1667	T2939	T2940	compound	LACZ,expression
R1668	T2940	T2938	dobj	expression,precede
R1669	T2941	T2938	prep	during,precede
R1670	T2942	T2943	amod	successive,development
R1671	T2943	T2941	pobj	development,during
R1672	T2944	T2943	prep	of,development
R1673	T2945	T2944	pobj	joints,of
R1674	T2946	T2943	prep	in,development
R1675	T2947	T2948	det	the,digits
R1676	T2948	T2946	pobj	digits,in
R1677	T2949	T2950	punct	(,Figure
R1678	T2950	T2915	parataxis	Figure,seen
R1679	T2951	T2950	nummod	1C,Figure
R1680	T2952	T2950	punct	),Figure
R1681	T2953	T2954	punct	(,data
R1682	T2954	T2915	meta	data,seen
R1683	T2955	T2954	amod	unpublished,data
R1684	T2956	T2954	punct	),data
R1685	T2957	T2915	punct	.,seen
R1686	T2959	T2960	det	These,experiments
R1687	T2960	T2961	nsubj	experiments,demonstrate
R1688	T2962	T2961	advmod	clearly,demonstrate
R1689	T2963	T2964	mark	that,expresses
R1690	T2964	T2961	ccomp	expresses,demonstrate
R1691	T2965	T2966	det	the,transgene
R1692	T2966	T2964	nsubj	transgene,expresses
R1693	T2967	T2968	compound	Gdf5,Cre
R1694	T2968	T2966	compound	Cre,transgene
R1695	T2969	T2968	punct	-,Cre
R1696	T2970	T2971	compound	Cre,recombinase
R1697	T2971	T2964	dobj	recombinase,expresses
R1698	T2972	T2964	cc	and,expresses
R1699	T2973	T2964	conj	causes,expresses
R1700	T2974	T2975	compound	DNA,recombination
R1701	T2975	T2973	dobj	recombination,causes
R1702	T2976	T2964	prep	in,expresses
R1703	T2977	T2978	amod	developing,regions
R1704	T2978	T2976	pobj	regions,in
R1705	T2979	T2978	compound	joint,regions
R1706	T2980	T2961	punct	.,demonstrate
R1707	T2982	T2983	nmod	GAC,A
R1708	T2983	T2985	nmod	A,mice
R1709	T2984	T2983	punct	(,A
R1710	T2985	T2987	nsubjpass	mice,crossed
R1711	T2986	T2983	punct	),A
R1712	T2988	T2987	auxpass	were,crossed
R1713	T2989	T2987	prep	with,crossed
R1714	T2990	T2991	nmod	lacZ,Cre
R1715	T2991	T2993	nmod	Cre,reporter
R1716	T2992	T2991	nmod	ROSA26,Cre
R1717	T2993	T2994	nmod	reporter,strain
R1718	T2994	T2995	nmod	strain,mice
R1719	T2995	T2989	pobj	mice,with
R1720	T2996	T2997	punct	(,R26R
R1721	T2997	T2994	appos	R26R,strain
R1722	T2998	T2997	punct	),R26R
R1723	T2999	T3000	aux	to,analyze
R1724	T3000	T2987	advcl	analyze,crossed
R1725	T3001	T3002	det	the,pattern
R1726	T3002	T3000	dobj	pattern,analyze
R1727	T3003	T3002	prep	of,pattern
R1728	T3004	T3005	npadvmod	Cre,mediated
R1729	T3005	T3007	amod	mediated,recombination
R1730	T3006	T3005	punct	-,mediated
R1731	T3007	T3003	pobj	recombination,of
R1732	T3008	T3007	compound	lacZ,recombination
R1733	T3009	T3000	prep	throughout,analyze
R1734	T3010	T3009	pobj	development,throughout
R1735	T3011	T2987	punct	.,crossed
R1736	T3013	T3014	nsubj	Joints,begin
R1737	T3015	T3013	prep	in,Joints
R1738	T3016	T3017	amod	developing,limbs
R1739	T3017	T3015	pobj	limbs,in
R1740	T3018	T3014	xcomp	forming,begin
R1741	T3019	T3018	prep	in,forming
R1742	T3020	T3021	det	a,pattern
R1743	T3021	T3019	pobj	pattern,in
R1744	T3022	T3023	amod	proximal,distal
R1745	T3023	T3021	amod	distal,pattern
R1746	T3024	T3023	punct	-,distal
R1747	T3025	T3026	amod	such,forms
R1748	T3026	T3018	advcl	forms,forming
R1749	T3027	T3026	mark	that,forms
R1750	T3028	T3029	det	the,joint
R1751	T3029	T3026	nsubj	joint,forms
R1752	T3030	T3029	compound	shoulder,joint
R1753	T3031	T3026	advmod	prior,forms
R1754	T3032	T3031	prep	to,prior
R1755	T3033	T3034	det	the,joint
R1756	T3034	T3032	pobj	joint,to
R1757	T3035	T3034	compound	elbow,joint
R1758	T3036	T3014	punct	.,begin
R1759	T3038	T3039	prep	In,defined
R1760	T3040	T3038	pobj	addition,In
R1761	T3041	T3039	punct	", ",defined
R1762	T3042	T3043	nummod	three,stages
R1763	T3043	T3039	nsubjpass	stages,defined
R1764	T3044	T3043	amod	major,stages
R1765	T3045	T3043	prep	of,stages
R1766	T3046	T3047	amod	early,development
R1767	T3047	T3045	pobj	development,of
R1768	T3048	T3047	compound	joint,development
R1769	T3049	T3039	aux	have,defined
R1770	T3050	T3039	auxpass	been,defined
R1771	T3051	T3039	agent	by,defined
R1772	T3052	T3051	pobj	histology,by
R1773	T3053	T3039	prep	as,defined
R1774	T3054	T3055	punct	(,1
R1775	T3055	T3056	meta	1,formation
R1776	T3056	T3053	pobj	formation,as
R1777	T3057	T3055	punct	),1
R1778	T3058	T3056	compound	interzone,formation
R1779	T3059	T3056	punct	", ",formation
R1780	T3060	T3061	punct	(,2
R1781	T3061	T3062	meta	2,formation
R1782	T3062	T3056	conj	formation,formation
R1783	T3063	T3061	punct	),2
R1784	T3064	T3065	nummod	three,layer
R1785	T3065	T3062	compound	layer,formation
R1786	T3066	T3065	punct	-,layer
R1787	T3067	T3062	compound	interzone,formation
R1788	T3068	T3062	punct	", ",formation
R1789	T3069	T3062	cc	and,formation
R1790	T3070	T3071	punct	(,3
R1791	T3071	T3072	meta	3,cavitation
R1792	T3072	T3062	conj	cavitation,formation
R1793	T3073	T3071	punct	),3
R1794	T3074	T3075	punct	(,Mitrovic
R1795	T3075	T3039	meta	Mitrovic,defined
R1796	T3076	T3075	nummod	1978,Mitrovic
R1797	T3077	T3075	punct	),Mitrovic
R1798	T3078	T3039	punct	.,defined
R1799	T3080	T3081	advcl	Consistent,seen
R1800	T3082	T3080	prep	with,Consistent
R1801	T3083	T3084	det	the,pattern
R1802	T3084	T3082	pobj	pattern,with
R1803	T3085	T3086	amod	proximal,distal
R1804	T3086	T3084	amod	distal,pattern
R1805	T3087	T3086	punct	-,distal
R1806	T3088	T3084	prep	of,pattern
R1807	T3089	T3090	compound	joint,development
R1808	T3090	T3088	pobj	development,of
R1809	T3091	T3084	prep	in,pattern
R1810	T3092	T3093	det	the,limbs
R1811	T3093	T3091	pobj	limbs,in
R1812	T3094	T3081	punct	", ",seen
R1813	T3095	T3096	compound	LACZ,activity
R1814	T3096	T3081	nsubjpass	activity,seen
R1815	T3097	T3081	auxpass	is,seen
R1816	T3098	T3081	prep	at,seen
R1817	T3099	T3100	amod	embryonic,day
R1818	T3100	T3098	pobj	day,at
R1819	T3101	T3100	nummod	12.5,day
R1820	T3102	T3100	punct	(,day
R1821	T3103	T3100	appos	E12.5,day
R1822	T3104	T3100	punct	),day
R1823	T3105	T3081	prep	in,seen
R1824	T3106	T3107	det	the,joints
R1825	T3107	T3105	pobj	joints,in
R1826	T3108	T3109	advmod	more,proximal
R1827	T3109	T3107	amod	proximal,joints
R1828	T3110	T3107	punct	", ",joints
R1829	T3111	T3107	prep	including,joints
R1830	T3112	T3113	det	the,shoulder
R1831	T3113	T3111	pobj	shoulder,including
R1832	T3114	T3113	cc	and,shoulder
R1833	T3115	T3113	conj	knee,shoulder
R1834	T3116	T3117	punct	(,data
R1835	T3117	T3081	meta	data,seen
R1836	T3118	T3117	amod	unpublished,data
R1837	T3119	T3117	punct	),data
R1838	T3120	T3081	punct	.,seen
R1839	T3122	T3123	prep	By,seen
R1840	T3124	T3122	pobj	E14.5,By
R1841	T3125	T3123	punct	", ",seen
R1842	T3126	T3127	compound	LACZ,expression
R1843	T3127	T3123	nsubjpass	expression,seen
R1844	T3128	T3123	auxpass	is,seen
R1845	T3129	T3123	advmod	typically,seen
R1846	T3130	T3123	prep	in,seen
R1847	T3131	T3130	pobj	all,in
R1848	T3132	T3131	prep	but,all
R1849	T3133	T3134	det	the,joints
R1850	T3134	T3132	pobj	joints,but
R1851	T3135	T3136	advmod	most,distal
R1852	T3136	T3134	amod	distal,joints
R1853	T3137	T3134	prep	of,joints
R1854	T3138	T3139	det	the,limbs
R1855	T3139	T3137	pobj	limbs,of
R1856	T3140	T3141	punct	(,1B
R1857	T3141	T3123	parataxis	1B,seen
R1858	T3142	T3141	nmod	Figure,1B
R1859	T3143	T3141	cc	and,1B
R1860	T3144	T3141	conj	1C,1B
R1861	T3145	T3141	punct	),1B
R1862	T3146	T3123	punct	", ",seen
R1863	T3147	T3123	cc	but,seen
R1864	T3148	T3147	prep	with,but
R1865	T3149	T3150	det	some,variability
R1866	T3150	T3148	pobj	variability,with
R1867	T3151	T3150	prep	in,variability
R1868	T3152	T3153	preconj	both,strength
R1869	T3153	T3151	pobj	strength,in
R1870	T3154	T3153	cc	and,strength
R1871	T3155	T3153	conj	extent,strength
R1872	T3156	T3153	prep	of,strength
R1873	T3157	T3156	pobj	expression,of
R1874	T3158	T3150	prep	from,variability
R1875	T3159	T3158	pobj	embryo,from
R1876	T3160	T3158	prep	to,from
R1877	T3161	T3160	pobj	embryo,to
R1878	T3162	T3123	punct	.,seen
R1879	T3164	T3165	det	The,embryos
R1880	T3165	T3169	nsubj	embryos,have
R1881	T3166	T3167	advmod	strongest,staining
R1882	T3167	T3165	amod	staining,embryos
R1883	T3168	T3167	punct	-,staining
R1884	T3170	T3169	advmod	often,have
R1885	T3171	T3172	amod	additional,staining
R1886	T3172	T3169	dobj	staining,have
R1887	T3173	T3172	prep	in,staining
R1888	T3174	T3173	pobj	fingertips,in
R1889	T3175	T3176	punct	(,seen
R1890	T3176	T3169	parataxis	seen,have
R1891	T3177	T3176	neg	not,seen
R1892	T3178	T3176	prep	in,seen
R1893	T3179	T3180	det	the,embryo
R1894	T3180	T3178	pobj	embryo,in
R1895	T3181	T3180	compound	E14.5,embryo
R1896	T3182	T3180	prep	in,embryo
R1897	T3183	T3182	pobj	Figure,in
R1898	T3184	T3183	nummod	1C,Figure
R1899	T3185	T3176	punct	", ",seen
R1900	T3186	T3176	cc	but,seen
R1901	T3187	T3188	advmod	clearly,detectable
R1902	T3188	T3176	conj	detectable,seen
R1903	T3189	T3188	prep	in,detectable
R1904	T3190	T3191	det	the,embryo
R1905	T3191	T3189	pobj	embryo,in
R1906	T3192	T3191	compound	E13.5,embryo
R1907	T3193	T3191	acl	shown,embryo
R1908	T3194	T3193	prep	in,shown
R1909	T3195	T3194	pobj	Figure,in
R1910	T3196	T3195	nummod	2,Figure
R1911	T3197	T3176	punct	),seen
R1912	T3198	T3169	punct	.,have
R1913	T3200	T3201	nsubj	Sections,show
R1914	T3202	T3200	prep	through,Sections
R1915	T3203	T3204	amod	developing,joints
R1916	T3204	T3202	pobj	joints,through
R1917	T3205	T3206	mark	that,is
R1918	T3206	T3201	ccomp	is,show
R1919	T3207	T3206	nsubj	LACZ,is
R1920	T3208	T3206	acomp	present,is
R1921	T3209	T3206	prep	in,is
R1922	T3210	T3211	amod	many,cells
R1923	T3211	T3209	pobj	cells,in
R1924	T3212	T3206	prep	at,is
R1925	T3213	T3214	det	the,stage
R1926	T3214	T3212	pobj	stage,at
R1927	T3215	T3214	compound	interzone,stage
R1928	T3216	T3217	punct	(,data
R1929	T3217	T3201	meta	data,show
R1930	T3218	T3217	amod	unpublished,data
R1931	T3219	T3217	punct	),data
R1932	T3220	T3201	punct	.,show
R1933	T3222	T3223	advmod	However,achieved
R1934	T3224	T3223	punct	", ",achieved
R1935	T3225	T3223	nsubjpass	expression,achieved
R1936	T3226	T3225	prep	of,expression
R1937	T3227	T3226	pobj	LACZ,of
R1938	T3228	T3225	prep	in,expression
R1939	T3229	T3230	advmod	nearly,100
R1940	T3230	T3231	nummod	100,%
R1941	T3231	T3228	pobj	%,in
R1942	T3232	T3231	prep	of,%
R1943	T3233	T3234	compound	joint,cells
R1944	T3234	T3232	pobj	cells,of
R1945	T3235	T3223	auxpass	is,achieved
R1946	T3236	T3223	neg	not,achieved
R1947	T3237	T3223	prep	until,achieved
R1948	T3238	T3239	det	the,stage
R1949	T3239	T3237	pobj	stage,until
R1950	T3240	T3241	nummod	three,layer
R1951	T3241	T3239	compound	layer,stage
R1952	T3242	T3241	punct	-,layer
R1953	T3243	T3239	compound	interzone,stage
R1954	T3244	T3245	punct	(,for
R1955	T3245	T3223	parataxis	for,achieved
R1956	T3246	T3245	pobj	example,for
R1957	T3247	T3245	punct	", ",for
R1958	T3248	T3245	conj	in,for
R1959	T3249	T3250	det	the,joint
R1960	T3250	T3248	pobj	joint,in
R1961	T3251	T3250	compound	knee,joint
R1962	T3252	T3250	prep	at,joint
R1963	T3253	T3252	pobj	E14.5,at
R1964	T3254	T3248	cc	or,in
R1965	T3255	T3248	conj	in,in
R1966	T3256	T3255	pobj	any,in
R1967	T3257	T3256	prep	of,any
R1968	T3258	T3259	det	the,joints
R1969	T3259	T3257	pobj	joints,of
R1970	T3260	T3259	amod	phalangeal,joints
R1971	T3261	T3256	prep	at,any
R1972	T3262	T3261	pobj	E16.5,at
R1973	T3263	T3264	punct	(,data
R1974	T3264	T3223	meta	data,achieved
R1975	T3265	T3264	amod	unpublished,data
R1976	T3266	T3264	punct	),data
R1977	T3267	T3223	punct	.,achieved
R1978	T3269	T3270	prep	Within,remains
R1979	T3271	T3272	det	the,skeleton
R1980	T3272	T3269	pobj	skeleton,Within
R1981	T3273	T3272	amod	developing,skeleton
R1982	T3274	T3270	punct	", ",remains
R1983	T3275	T3276	npadvmod	Cre,mediated
R1984	T3276	T3278	amod	mediated,expression
R1985	T3277	T3276	punct	-,mediated
R1986	T3278	T3270	nsubj	expression,remains
R1987	T3279	T3278	prep	of,expression
R1988	T3280	T3279	pobj	LACZ,of
R1989	T3281	T3282	advmod	strikingly,specific
R1990	T3282	T3270	oprd	specific,remains
R1991	T3283	T3282	prep	to,specific
R1992	T3284	T3283	pobj	joints,to
R1993	T3285	T3270	prep	throughout,remains
R1994	T3286	T3285	pobj	development,throughout
R1995	T3287	T3270	punct	.,remains
R1996	T3289	T3290	advmod	Furthermore,seen
R1997	T3291	T3290	punct	", ",seen
R1998	T3292	T3290	nsubjpass	it,seen
R1999	T3293	T3290	auxpass	is,seen
R2000	T3294	T3290	prep	in,seen
R2001	T3295	T3296	predet	all,structures
R2002	T3296	T3294	pobj	structures,in
R2003	T3297	T3296	det	the,structures
R2004	T3298	T3296	prep	of,structures
R2005	T3299	T3300	amod	postnatal,joints
R2006	T3300	T3298	pobj	joints,of
R2007	T3301	T3300	amod	synovial,joints
R2008	T3302	T3296	prep	including,structures
R2009	T3303	T3304	det	the,cartilage
R2010	T3304	T3302	pobj	cartilage,including
R2011	T3305	T3304	amod	articular,cartilage
R2012	T3306	T3304	punct	", ",cartilage
R2013	T3307	T3308	compound	joint,capsule
R2014	T3308	T3304	conj	capsule,cartilage
R2015	T3309	T3308	punct	", ",capsule
R2016	T3310	T3308	cc	and,capsule
R2017	T3311	T3312	amod	synovial,membrane
R2018	T3312	T3308	conj	membrane,capsule
R2019	T3313	T3314	punct	(,Figure
R2020	T3314	T3290	parataxis	Figure,seen
R2021	T3315	T3314	nummod	1D,Figure
R2022	T3316	T3314	cc	and,Figure
R2023	T3317	T3314	conj	1E,Figure
R2024	T3318	T3314	punct	),Figure
R2025	T3319	T3320	punct	(,data
R2026	T3320	T3290	meta	data,seen
R2027	T3321	T3320	amod	unpublished,data
R2028	T3322	T3320	punct	),data
R2029	T3323	T3290	punct	.,seen
R2030	T3325	T3326	det	These,patterns
R2031	T3326	T3327	nsubj	patterns,are
R2032	T3328	T3327	acomp	consistent,are
R2033	T3329	T3328	prep	with,consistent
R2034	T3330	T3331	det	the,expression
R2035	T3331	T3329	pobj	expression,with
R2036	T3332	T3333	advmod	well,established
R2037	T3333	T3331	amod	established,expression
R2038	T3334	T3333	punct	-,established
R2039	T3335	T3331	prep	of,expression
R2040	T3336	T3335	pobj	Gdf5,of
R2041	T3337	T3331	prep	in,expression
R2042	T3338	T3339	compound	interzone,regions
R2043	T3339	T3337	pobj	regions,in
R2044	T3340	T3331	prep	during,expression
R2045	T3341	T3342	amod	embryonic,development
R2046	T3342	T3340	pobj	development,during
R2047	T3343	T3344	punct	(,Storm
R2048	T3344	T3327	meta	Storm,are
R2049	T3345	T3344	cc	and,Storm
R2050	T3346	T3344	conj	Kingsley,Storm
R2051	T3347	T3346	nummod	1996,Kingsley
R2052	T3348	T3346	punct	),Kingsley
R2053	T3349	T3327	punct	.,are
R2054	T3351	T3352	compound	Adult,patterns
R2055	T3352	T3354	nsubj	patterns,are
R2056	T3353	T3352	compound	expression,patterns
R2057	T3355	T3352	prep	of,patterns
R2058	T3356	T3357	det	the,gene
R2059	T3357	T3355	pobj	gene,of
R2060	T3358	T3357	compound	Gdf5,gene
R2061	T3359	T3354	neg	not,are
R2062	T3360	T3361	advmod	as,characterized
R2063	T3361	T3354	acomp	characterized,are
R2064	T3362	T3361	advmod	well,characterized
R2065	T3363	T3354	punct	", ",are
R2066	T3364	T3354	cc	but,are
R2067	T3365	T3366	compound	Gdf5,expression
R2068	T3366	T3367	nsubjpass	expression,detected
R2069	T3367	T3354	conj	detected,are
R2070	T3368	T3367	aux	has,detected
R2071	T3369	T3367	advmod	previously,detected
R2072	T3370	T3367	auxpass	been,detected
R2073	T3371	T3367	prep	in,detected
R2074	T3372	T3373	nmod	adult,cartilage
R2075	T3479	T3480	prep	At,expressed
R2076	T3481	T3479	pobj	birth,At
R2077	T3482	T3480	punct	", ",expressed
R2078	T3483	T3480	nsubjpass	LACZ,expressed
R2079	T3484	T3480	auxpass	is,expressed
R2080	T3373	T3371	pobj	cartilage,in
R2081	T3485	T3480	advmod	also,expressed
R2082	T3374	T3373	amod	articular,cartilage
R2083	T3486	T3480	prep	in,expressed
R2084	T3375	T3367	advcl	using,detected
R2085	T3376	T3377	preconj	both,PCR
R2086	T3377	T3375	dobj	PCR,using
R2087	T3378	T3377	compound	RT,PCR
R2088	T3379	T3377	punct	-,PCR
R2089	T3487	T3486	pobj	tendons,in
R2090	T3380	T3377	cc	and,PCR
R2091	T3381	T3377	conj	immunocytochemistry,PCR
R2092	T3382	T3383	punct	(,Chang
R2093	T3383	T3367	meta	Chang,detected
R2094	T3384	T3383	nmod	et,Chang
R2095	T3488	T3487	acl	running,tendons
R2096	T3385	T3383	nmod	al.,Chang
R2097	T3386	T3383	nummod	1994,Chang
R2098	T3387	T3383	punct	;,Chang
R2099	T3489	T3488	prep	along,running
R2100	T3388	T3383	nmod	Erlacher,Chang
R2101	T3490	T3491	det	the,column
R2102	T3491	T3489	pobj	column,along
R2103	T3389	T3383	nmod	et,Chang
R2104	T3390	T3383	nmod	al.,Chang
R2105	T3391	T3383	nummod	1998,Chang
R2106	T3492	T3491	amod	vertebral,column
R2107	T3392	T3383	punct	;,Chang
R2108	T3393	T3383	nmod	Bobacz,Chang
R2109	T3493	T3487	punct	", ",tendons
R2110	T3394	T3383	nmod	et,Chang
R2111	T3395	T3383	nmod	al.,Chang
R2112	T3396	T3383	nummod	2002,Chang
R2113	T3494	T3487	conj	regions,tendons
R2114	T3397	T3383	punct	),Chang
R2115	T3398	T3367	punct	.,detected
R2116	T3495	T3494	prep	of,regions
R2117	T3400	T3401	amod	Other,sites
R2118	T3496	T3495	pobj	tendons,of
R2119	T3401	T3402	nsubj	sites,have
R2120	T3497	T3494	prep	in,regions
R2121	T3403	T3401	prep	besides,sites
R2122	T3404	T3405	compound	limb,joints
R2123	T3498	T3499	det	the,wrist
R2124	T3405	T3403	pobj	joints,besides
R2125	T3406	T3402	advmod	also,have
R2126	T3407	T3408	npadvmod	Cre,mediated
R2127	T3408	T3410	amod	mediated,expression
R2128	T3499	T3497	pobj	wrist,in
R2129	T3409	T3408	punct	-,mediated
R2130	T3410	T3402	dobj	expression,have
R2131	T3411	T3410	compound	lacZ,expression
R2132	T3500	T3499	cc	and,wrist
R2133	T3412	T3402	punct	.,have
R2134	T3414	T3415	advcl	Starting,detected
R2135	T3501	T3499	conj	ankle,wrist
R2136	T3416	T3414	prep	at,Starting
R2137	T3502	T3494	punct	", ",regions
R2138	T3417	T3416	pobj	E13.5,at
R2139	T3418	T3415	punct	", ",detected
R2140	T3419	T3420	compound	LACZ,activity
R2141	T3420	T3415	nsubjpass	activity,detected
R2142	T3421	T3415	auxpass	is,detected
R2143	T3422	T3415	prep	in,detected
R2144	T3423	T3424	det	an,domain
R2145	T3503	T3494	cc	and,regions
R2146	T3424	T3422	pobj	domain,in
R2147	T3425	T3424	amod	anterior,domain
R2148	T3426	T3425	cc	and,anterior
R2149	T3427	T3425	conj	posterior,anterior
R2150	T3504	T3505	det	some,insertions
R2151	T3428	T3424	prep	of,domain
R2152	T3429	T3430	det	the,bud
R2153	T3505	T3494	conj	insertions,regions
R2154	T3430	T3428	pobj	bud,of
R2155	T3431	T3430	compound	limb,bud
R2156	T3432	T3433	punct	(,Figure
R2157	T3506	T3505	compound	tendon,insertions
R2158	T3433	T3415	parataxis	Figure,detected
R2159	T3434	T3433	nummod	2C,Figure
R2160	T3435	T3433	punct	),Figure
R2161	T3507	T3508	punct	(,Figure
R2162	T3436	T3415	punct	.,detected
R2163	T3438	T3439	prep	At,is
R2164	T3508	T3480	parataxis	Figure,expressed
R2165	T3440	T3438	pobj	E14.5,At
R2166	T3441	T3439	punct	", ",is
R2167	T3509	T3508	nummod	1D,Figure
R2168	T3442	T3443	compound	LACZ,activity
R2169	T3443	T3439	nsubj	activity,is
R2170	T3510	T3508	punct	),Figure
R2171	T3444	T3439	acomp	detectable,is
R2172	T3445	T3439	prep	in,is
R2173	T3446	T3447	det	the,pinnae
R2174	T3511	T3512	punct	(,data
R2175	T3447	T3445	pobj	pinnae,in
R2176	T3448	T3447	amod	developing,pinnae
R2177	T3449	T3447	compound	ear,pinnae
R2178	T3512	T3480	meta	data,expressed
R2179	T3450	T3447	punct	", ",pinnae
R2180	T3451	T3447	appos	ribs,pinnae
R2181	T3513	T3512	amod	unpublished,data
R2182	T3452	T3447	punct	", ",pinnae
R2183	T3453	T3447	appos	sternum,pinnae
R2184	T3454	T3447	punct	", ",pinnae
R2185	T3514	T3512	punct	),data
R2186	T3455	T3447	appos	tissues,pinnae
R2187	T3456	T3439	prep	in,is
R2188	T3457	T3458	det	the,face
R2189	T3515	T3480	punct	.,expressed
R2190	T3458	T3456	pobj	face,in
R2191	T3459	T3458	punct	", ",face
R2192	T3460	T3458	cc	and,face
R2193	T3461	T3462	det	some,regions
R2194	T3462	T3458	conj	regions,face
R2195	T3463	T3462	prep	of,regions
R2196	T3517	T3518	prep	By,expressed
R2197	T3464	T3465	det	the,brain
R2198	T3465	T3463	pobj	brain,of
R2199	T3466	T3465	cc	and,brain
R2200	T3467	T3468	amod	spinal,cord
R2201	T3468	T3465	conj	cord,brain
R2202	T3519	T3520	nummod	5,wk
R2203	T3469	T3470	punct	(,Figure
R2204	T3470	T3439	parataxis	Figure,is
R2205	T3471	T3470	nummod	1B,Figure
R2206	T3472	T3470	punct	),Figure
R2207	T3473	T3474	punct	(,data
R2208	T3520	T3517	pobj	wk,By
R2209	T3474	T3439	meta	data,is
R2210	T3475	T3474	amod	unpublished,data
R2211	T3521	T3520	prep	of,wk
R2212	T3476	T3474	punct	),data
R2213	T3522	T3521	pobj	age,of
R2214	T3477	T3439	punct	.,is
R2215	T3523	T3518	punct	", ",expressed
R2216	T3524	T3518	nsubjpass	LACZ,expressed
R2217	T3525	T3518	auxpass	is,expressed
R2218	T3526	T3518	advmod	also,expressed
R2219	T3527	T3518	prep	in,expressed
R2220	T3528	T3529	det	the,follicles
R2221	T3529	T3527	pobj	follicles,in
R2222	T3530	T3529	compound	hair,follicles
R2223	T3585	T3586	dep	which,extend
R2224	T3531	T3529	punct	", ",follicles
R2225	T3586	T3579	relcl	extend,expression
R2226	T3587	T3586	aux	can,extend
R2227	T3588	T3586	prep	throughout,extend
R2228	T3532	T3533	compound	ear,cartilage
R2229	T3589	T3590	amod	many,tissues
R2230	T3590	T3588	pobj	tissues,throughout
R2231	T3591	T3590	amod	different,tissues
R2232	T3533	T3529	appos	cartilage,follicles
R2233	T3592	T3590	prep	in,tissues
R2234	T3593	T3594	det	the,animal
R2235	T3594	T3592	pobj	animal,in
R2236	T3534	T3529	punct	", ",follicles
R2237	T3595	T3561	punct	.,show
R2238	T3535	T3536	det	some,cells
R2239	T3597	T3598	advmod	However,is
R2240	T3599	T3598	punct	", ",is
R2241	T3536	T3529	conj	cells,follicles
R2242	T3600	T3601	amod	sustained,expression
R2243	T3601	T3598	nsubj	expression,is
R2244	T3602	T3601	prep	of,expression
R2245	T3603	T3604	det	the,transgene
R2246	T3604	T3602	pobj	transgene,of
R2247	T3605	T3604	appos	itself,transgene
R2248	T3537	T3536	prep	in,cells
R2249	T3606	T3598	punct	", ",is
R2250	T3607	T3608	mark	as,assayed
R2251	T3608	T3598	advcl	assayed,is
R2252	T3538	T3539	det	the,plate
R2253	T3609	T3608	prep	by,assayed
R2254	T3610	T3611	compound	HPLAP,activity
R2255	T3611	T3609	pobj	activity,by
R2256	T3539	T3537	pobj	plate,in
R2257	T3612	T3598	punct	", ",is
R2258	T3613	T3598	advmod	still,is
R2259	T3614	T3598	acomp	restricted,is
R2260	T3540	T3539	compound	growth,plate
R2261	T3615	T3616	advmod	primarily,to
R2262	T3616	T3614	prep	to,restricted
R2263	T3617	T3616	pobj	joints,to
R2264	T3541	T3539	prep	of,plate
R2265	T3618	T3617	prep	in,joints
R2266	T3619	T3618	pobj	animals,in
R2267	T3620	T3621	dep	that,show
R2268	T3542	T3543	det	the,bones
R2269	T3621	T3619	relcl	show,animals
R2270	T3622	T3621	dobj	evidence,show
R2271	T3623	T3622	prep	of,evidence
R2272	T3543	T3541	pobj	bones,of
R2273	T3624	T3625	advmod	more,generalized
R2274	T3625	T3626	amod	generalized,recombination
R2275	T3626	T3623	pobj	recombination,of
R2276	T3544	T3543	amod	long,bones
R2277	T3627	T3621	prep	based,show
R2278	T3628	T3627	prep	on,based
R2279	T3629	T3630	compound	LACZ,expression
R2280	T3545	T3536	punct	", ",cells
R2281	T3630	T3628	pobj	expression,on
R2282	T3631	T3632	punct	(,data
R2283	T3632	T3598	meta	data,is
R2284	T3546	T3536	cc	and,cells
R2285	T3633	T3632	amod	unpublished,data
R2286	T3634	T3632	punct	),data
R2287	T3635	T3598	punct	.,is
R2288	T3547	T3536	conj	portions,cells
R2289	T3637	T3638	nsubj	This,suggests
R2290	T3548	T3547	prep	of,portions
R2291	T3639	T3640	mark	that,is
R2292	T3549	T3550	det	the,brain
R2293	T3550	T3548	pobj	brain,of
R2294	T3640	T3638	ccomp	is,suggests
R2295	T3641	T3640	prep	in,is
R2296	T3642	T3643	det	a,fraction
R2297	T3643	T3641	pobj	fraction,in
R2298	T3644	T3643	prep	of,fraction
R2299	T3551	T3550	cc	and,brain
R2300	T3645	T3644	pobj	animals,of
R2301	T3646	T3640	punct	", ",is
R2302	T3647	T3648	amod	sporadic,expression
R2303	T3552	T3553	amod	spinal,cord
R2304	T3648	T3640	nsubj	expression,is
R2305	T3649	T3648	prep	of,expression
R2306	T3650	T3649	pobj	Cre,of
R2307	T3553	T3550	conj	cord,brain
R2311	T3554	T3555	punct	(,data
R2312	T3654	T3653	advmod	early,time
R2313	T3655	T3654	prep	in,early
R2314	T3656	T3655	pobj	development,in
R2315	T3555	T3547	meta	data,portions
R2316	T3657	T3640	acomp	sufficient,is
R2317	T3658	T3659	aux	to,lead
R2318	T3556	T3555	amod	unpublished,data
R2319	T3659	T3657	xcomp	lead,sufficient
R2320	T3660	T3659	prep	to,lead
R2321	T3661	T3662	preconj	both,recombination
R2322	T3557	T3555	punct	),data
R2323	T3662	T3660	pobj	recombination,to
R2324	T3663	T3662	amod	ectopic,recombination
R2325	T3664	T3662	cc	and,recombination
R2326	T3558	T3518	punct	.,expressed
R2327	T3665	T3666	compound	LACZ,expression
R2328	T3666	T3662	conj	expression,recombination
R2329	T3667	T3638	punct	.,suggests
R2330	T3560	T3561	advmod	Surprisingly,show
R2331	T3669	T3670	mark	While,tracked
R2332	T3670	T3681	advcl	tracked,offer
R2333	T3671	T3672	det	the,fraction
R2334	T3562	T3561	punct	", ",show
R2335	T3672	T3670	nsubj	fraction,tracked
R2336	T3673	T3672	prep	of,fraction
R2337	T3674	T3673	pobj	animals,of
R2338	T3563	T3564	quantmod	23,63
R2339	T3675	T3674	prep	with,animals
R2340	T3676	T3677	amod	broader,patterns
R2341	T3677	T3675	pobj	patterns,with
R2342	T3564	T3561	nsubj	63,show
R2343	T3678	T3677	compound	recombination,patterns
R2344	T3679	T3670	aux	must,tracked
R2345	T3680	T3670	aux	be,tracked
R2346	T3682	T3670	cc	and,tracked
R2347	T3683	T3670	conj	accounted,tracked
R2348	T3565	T3564	quantmod	of,63
R2349	T3684	T3683	prep	for,accounted
R2350	T3685	T3670	prep	during,tracked
R2351	T3686	T3685	pobj	experiments,during
R2352	T3566	T3564	punct	", ",63
R2353	T3687	T3681	punct	", ",offer
R2354	T3688	T3689	det	these,animals
R2355	T3689	T3681	nsubj	animals,offer
R2356	T3567	T3564	cc	or,63
R2357	T3690	T3691	det	the,benefit
R2358	T3568	T3569	nummod	37,%
R2359	T3569	T3564	conj	%,63
R2360	T3691	T3681	dobj	benefit,offer
R2361	T3570	T3564	prep	of,63
R2362	T3692	T3691	amod	potential,benefit
R2363	T3693	T3691	prep	of,benefit
R2364	T3694	T3693	pcomp	revealing,of
R2365	T3571	T3572	amod	transgenic,mice
R2366	T3695	T3696	amod	additional,functions
R2367	T3696	T3694	dobj	functions,revealing
R2368	T3697	T3696	amod	new,functions
R2369	T3572	T3570	pobj	mice,of
R2370	T3698	T3696	prep	of,functions
R2371	T3699	T3700	compound	target,genes
R2372	T3700	T3698	pobj	genes,of
R2373	T3573	T3572	acl	analyzed,mice
R2374	T3701	T3702	dep	that,studied
R2375	T3702	T3700	relcl	studied,genes
R2376	T3703	T3702	aux	could,studied
R2377	T3574	T3561	advmod	also,show
R2378	T3704	T3702	auxpass	be,studied
R2379	T3705	T3702	advmod	subsequently,studied
R2380	T3706	T3702	prep	with,studied
R2381	T3575	T3576	det	some,degree
R2382	T3707	T3708	amod	additional,drivers
R2383	T3708	T3706	pobj	drivers,with
R2384	T3709	T3708	nmod	site,drivers
R2385	T3576	T3561	dobj	degree,show
R2386	T3710	T3709	punct	-,site
R2387	T3711	T3709	amod	specific,site
R2388	T3712	T3708	compound	Cre,drivers
R2389	T3577	T3576	prep	of,degree
R2390	T3713	T3681	punct	.,offer
R2391	T3578	T3579	amod	wider,expression
R2392	T3579	T3577	pobj	expression,of
R2393	T3580	T3579	punct	“,expression
R2394	T3581	T3579	amod	ectopic,expression
R2395	T3582	T3579	punct	”,expression
R2396	T3583	T3579	compound	LACZ,expression
R2397	T3584	T3579	punct	", ",expression
R2414	T3948	T3949	nmod	Gdf5,Cre
R2415	T3949	T3951	nmod	Cre,Animals
R2416	T3950	T3949	punct	-,Cre
R2417	T3951	T3954	nsubj	Animals,Survive
R2418	T3952	T3949	punct	/,Cre
R2419	T3953	T3949	appos	Bmpr1afloxP,Cre
R2420	T3955	T3954	prep	to,Survive
R2421	T3956	T3955	pobj	Adulthood,to
R2422	T3957	T3954	prep	with,Survive
R2423	T3958	T3959	nmod	Ear,Defects
R2424	T3959	T3957	pobj	Defects,with
R2425	T3960	T3958	punct	", ",Ear
R2426	T3961	T3958	conj	Webbing,Ear
R2427	T3962	T3961	punct	", ",Webbing
R2428	T3963	T3961	cc	and,Webbing
R2429	T3964	T3961	conj	Joint,Webbing
R2430	T3966	T3967	nsubj	We,used
R2431	T3968	T3967	advmod	next,used
R2432	T3969	T3970	det	the,system
R2433	T3970	T3967	dobj	system,used
R2434	T3971	T3972	compound	Gdf5,Cre
R2435	T3972	T3970	compound	Cre,system
R2436	T3973	T3972	punct	-,Cre
R2437	T3974	T3975	aux	to,test
R2438	T3975	T3967	advcl	test,used
R2439	T3976	T3977	det	the,role
R2440	T3977	T3975	dobj	role,test
R2441	T3978	T3977	prep	of,role
R2442	T3979	T3980	compound	BMP,signaling
R2443	T3980	T3978	pobj	signaling,of
R2444	T3981	T3975	prep	during,test
R2445	T3982	T3983	amod	normal,development
R2446	T3983	T3981	pobj	development,during
R2447	T3984	T3983	compound	joint,development
R2448	T3985	T3967	punct	.,used
R2449	T3987	T3988	nmod	Gdf5,Cre
R2450	T3988	T3990	nmod	Cre,mice
R2451	T3989	T3988	punct	-,Cre
R2452	T3990	T3992	nsubjpass	mice,bred
R2453	T3991	T3990	amod	transgenic,mice
R2454	T3993	T3992	auxpass	were,bred
R2455	T3994	T3992	prep	to,bred
R2456	T3995	T3994	pobj	animals,to
R2457	T3996	T3995	acl	carrying,animals
R2458	T3997	T3998	det	a,allele
R2459	T3998	T3996	dobj	allele,carrying
R2460	T3999	T3998	amod	conditional,allele
R2461	T4000	T3998	amod	floxed,allele
R2462	T4001	T3998	prep	of,allele
R2463	T4002	T4003	det	the,locus
R2464	T4003	T4001	pobj	locus,of
R2465	T4004	T4003	compound	Bmpr1a,locus
R2466	T4005	T4006	punct	(,Mishina
R2467	T4006	T3992	meta	Mishina,bred
R2468	T4007	T4006	nmod	et,Mishina
R2469	T4008	T4006	nmod	al.,Mishina
R2470	T4009	T4006	nummod	2002,Mishina
R2471	T4010	T4006	punct	),Mishina
R2472	T4011	T3992	punct	", ",bred
R2473	T4012	T4013	advmod	usually,in
R2474	T4013	T3992	prep	in,bred
R2475	T4014	T4015	det	the,presence
R2476	T4015	T4013	pobj	presence,in
R2477	T4016	T4015	prep	of,presence
R2478	T4017	T4018	det	the,allele
R2479	T4018	T4016	pobj	allele,of
R2480	T4019	T4020	compound	R26R,reporter
R2481	T4020	T4018	compound	reporter,allele
R2482	T4021	T4022	aux	to,facilitate
R2483	T4022	T3992	advcl	facilitate,bred
R2484	T4023	T4024	amod	simultaneous,visualization
R2485	T4024	T4022	dobj	visualization,facilitate
R2486	T4025	T4024	prep	of,visualization
R2487	T4026	T4027	npadvmod	Cre,mediated
R2488	T4027	T4029	amod	mediated,patterns
R2489	T4028	T4027	punct	-,mediated
R2490	T4029	T4025	pobj	patterns,of
R2491	T4030	T4029	compound	recombination,patterns
R2492	T4031	T4032	punct	(,see
R2493	T4032	T3992	parataxis	see,bred
R2494	T4033	T4034	amod	typical,cross
R2495	T4034	T4032	dobj	cross,see
R2496	T4035	T4032	prep	in,see
R2497	T4036	T4035	pobj	Figure,in
R2498	T4037	T4036	nummod	3,Figure
R2499	T4038	T4032	punct	),see
R2500	T4039	T3992	punct	.,bred
R2501	T4041	T4042	compound	PCR,amplification
R2502	T4042	T4043	nsubj	amplification,confirmed
R2503	T4044	T4045	mark	that,deleted
R2504	T4045	T4043	ccomp	deleted,confirmed
R2505	T4046	T4047	det	a,exon
R2506	T4047	T4045	nsubjpass	exon,deleted
R2507	T4048	T4047	amod	key,exon
R2508	T4049	T4047	prep	of,exon
R2509	T4050	T4051	det	the,gene
R2510	T4051	T4049	pobj	gene,of
R2511	T4052	T4051	compound	Bmpr1a,gene
R2512	T4053	T4045	auxpass	was,deleted
R2513	T4054	T4045	prep	in,deleted
R2514	T4055	T4054	pobj	mice,in
R2515	T4056	T4057	dep	that,carried
R2516	T4057	T4055	relcl	carried,mice
R2517	T4058	T4057	advmod	also,carried
R2518	T4059	T4060	det	the,transgene
R2519	T4060	T4057	dobj	transgene,carried
R2520	T4061	T4062	compound	Gdf5,Cre
R2521	T4062	T4060	compound	Cre,transgene
R2522	T4063	T4062	punct	-,Cre
R2523	T4064	T4065	punct	(,data
R2524	T4065	T4045	meta	data,deleted
R2525	T4066	T4065	amod	unpublished,data
R2526	T4067	T4065	punct	),data
R2527	T4068	T4043	punct	.,confirmed
R2528	T4070	T4071	amod	Previous,studies
R2529	T4071	T4072	nsubj	studies,shown
R2530	T4073	T4072	aux	have,shown
R2531	T4074	T4075	mark	that,mimics
R2532	T4075	T4072	ccomp	mimics,shown
R2533	T4076	T4077	det	the,allele
R2534	T4077	T4075	nsubj	allele,mimics
R2535	T4078	T4077	amod	recombined,allele
R2536	T4079	T4077	compound	Bmpr1afloxP,allele
R2537	T4080	T4081	det	a,allele
R2538	T4081	T4075	dobj	allele,mimics
R2539	T4082	T4081	amod	null,allele
R2540	T4083	T4081	prep	of,allele
R2541	T4084	T4085	det	the,locus
R2542	T4085	T4083	pobj	locus,of
R2543	T4086	T4085	compound	Bmpr1a,locus
R2544	T4087	T4088	advmod	when,transmitted
R2545	T4088	T4075	advcl	transmitted,mimics
R2546	T4089	T4088	prep	through,transmitted
R2547	T4090	T4091	det	the,germline
R2548	T4091	T4089	pobj	germline,through
R2549	T4092	T4093	punct	(,Mishina
R2550	T4093	T4072	meta	Mishina,shown
R2551	T4094	T4093	nmod	et,Mishina
R2552	T4095	T4093	nmod	al.,Mishina
R2553	T4096	T4093	nummod	2002,Mishina
R2554	T4097	T4093	punct	),Mishina
R2555	T4098	T4072	punct	.,shown
R2556	T4100	T4101	det	The,mice
R2557	T4101	T4109	nsubj	mice,were
R2558	T4102	T4103	nmod	Gdf5,Cre
R2559	T4103	T4105	nmod	Cre,Bmpr1afloxP
R2560	T4104	T4103	punct	-,Cre
R2561	T4105	T4107	nmod	Bmpr1afloxP,knockout
R2562	T4106	T4105	punct	/,Bmpr1afloxP
R2563	T4107	T4101	compound	knockout,mice
R2564	T4108	T4107	amod	conditional,knockout
R2565	T4110	T4109	acomp	viable,were
R2566	T4111	T4109	cc	and,were
R2567	T4112	T4109	conj	survived,were
R2568	T4113	T4112	prep	to,survived
R2569	T4114	T4113	pobj	adulthood,to
R2570	T4115	T4109	punct	", ",were
R2571	T4116	T4109	advcl	showing,were
R2572	T4117	T4118	mark	that,bypass
R2573	T4118	T4116	ccomp	bypass,showing
R2574	T4119	T4120	det	the,driver
R2575	T4120	T4118	nsubj	driver,bypass
R2576	T4121	T4122	compound	Gdf5,Cre
R2577	T4122	T4120	compound	Cre,driver
R2578	T4123	T4122	punct	-,Cre
R2579	T4124	T4118	aux	can,bypass
R2580	T4125	T4126	det	the,lethality
R2581	T4126	T4118	dobj	lethality,bypass
R2582	T4127	T4126	amod	early,lethality
R2583	T4128	T4126	amod	embryonic,lethality
R2584	T4129	T4130	advmod	previously,reported
R2585	T4130	T4126	acl	reported,lethality
R2586	T4131	T4130	prep	in,reported
R2587	T4132	T4131	pobj	animals,in
R2588	T4133	T4132	prep	with,animals
R2589	T4134	T4135	det	a,mutation
R2590	T4135	T4133	pobj	mutation,with
R2591	T4136	T4135	amod	null,mutation
R2592	T4137	T4135	prep	in,mutation
R2593	T4138	T4139	det	the,locus
R2594	T4139	T4137	pobj	locus,in
R2595	T4140	T4139	compound	Bmpr1a,locus
R2596	T4141	T4142	punct	(,Mishina
R2597	T4142	T4109	meta	Mishina,were
R2598	T4143	T4142	nmod	et,Mishina
R2599	T4144	T4142	nmod	al.,Mishina
R2600	T4145	T4142	nummod	1995,Mishina
R2601	T4146	T4142	punct	),Mishina
R2602	T4147	T4109	punct	.,were
R2603	T4149	T4150	det	The,mice
R2604	T4150	T4157	nsubj	mice,showed
R2605	T4151	T4150	amod	viable,mice
R2606	T4152	T4153	compound	Gdf5,Cre
R2607	T4153	T4155	compound	Cre,Bmpr1afloxP
R2608	T4154	T4153	punct	-,Cre
R2609	T4155	T4150	compound	Bmpr1afloxP,mice
R2610	T4156	T4155	punct	/,Bmpr1afloxP
R2611	T4158	T4159	amod	several,phenotypes
R2612	T4159	T4157	dobj	phenotypes,showed
R2613	T4160	T4157	punct	.,showed
R2614	T4162	T4163	advmod	First,had
R2615	T4164	T4163	punct	", ",had
R2616	T4165	T4166	det	the,mice
R2617	T4166	T4163	nsubj	mice,had
R2618	T4167	T4166	amod	conditional,mice
R2619	T4168	T4166	compound	knockout,mice
R2620	T4169	T4170	amod	shorter,ears
R2621	T4170	T4163	dobj	ears,had
R2622	T4171	T4172	dep	that,lay
R2623	T4172	T4170	relcl	lay,ears
R2624	T4173	T4172	advmod	often,lay
R2625	T4174	T4172	advcl	flatter,lay
R2626	T4175	T4174	prep	against,flatter
R2627	T4176	T4177	poss	their,heads
R2628	T4177	T4175	pobj	heads,against
R2629	T4178	T4174	prep	than,flatter
R2630	T4179	T4178	pobj	controls,than
R2631	T4180	T4181	punct	(,0.0001
R2632	T4181	T4163	parataxis	0.0001,had
R2633	T4182	T4183	nsubj	controls,mm
R2634	T4183	T4181	dep	mm,0.0001
R2635	T4184	T4185	quantmod	13.1,0.1
R2636	T4185	T4183	nummod	0.1,mm
R2637	T4186	T4185	punct	±,0.1
R2638	T4187	T4183	advmod	long,mm
R2639	T4188	T4181	punct	", ",0.0001
R2640	T4189	T4190	nsubj	n,38
R2641	T4190	T4181	ccomp	38,0.0001
R2642	T4191	T4190	punct	=,38
R2643	T4192	T4181	punct	;,0.0001
R2644	T4193	T4194	nsubj	mutants,mm
R2645	T4194	T4181	dep	mm,0.0001
R2646	T4195	T4196	quantmod	11.8,0.2
R2647	T4196	T4194	nummod	0.2,mm
R2648	T4197	T4196	punct	±,0.2
R2649	T4198	T4181	punct	", ",0.0001
R2650	T4199	T4200	nsubj	n,11
R2651	T4200	T4181	ccomp	11,0.0001
R2652	T4201	T4200	punct	=,11
R2653	T4202	T4181	punct	;,0.0001
R2654	T4203	T4181	nsubj	p,0.0001
R2655	T4204	T4181	punct	<,0.0001
R2656	T4205	T4181	punct	),0.0001
R2657	T4206	T4163	punct	.,had
R2658	T4208	T4209	compound	BMP,signaling
R2659	T4209	T4210	nsubjpass	signaling,known
R2660	T4211	T4210	auxpass	is,known
R2661	T4212	T4213	aux	to,required
R2662	T4213	T4210	xcomp	required,known
R2663	T4214	T4213	auxpass	be,required
R2664	T4215	T4213	prep	for,required
R2665	T4216	T4215	pobj	growth,for
R2666	T4217	T4216	prep	of,growth
R2667	T4218	T4219	det	the,ear
R2668	T4219	T4217	pobj	ear,of
R2669	T4220	T4219	amod	external,ear
R2670	T4221	T4219	prep	of,ear
R2671	T4222	T4221	pobj	mice,of
R2672	T4223	T4224	punct	(,Kingsley
R2673	T4224	T4210	meta	Kingsley,known
R2674	T4225	T4224	nmod	et,Kingsley
R2675	T4226	T4224	nmod	al.,Kingsley
R2676	T4227	T4224	nummod	1992,Kingsley
R2677	T4228	T4224	punct	),Kingsley
R2678	T4229	T4210	punct	", ",known
R2679	T4230	T4210	cc	and,known
R2680	T4231	T4232	det	this,phenotype
R2681	T4232	T4233	nsubj	phenotype,reflects
R2682	T4233	T4210	conj	reflects,known
R2683	T4234	T4233	advmod	likely,reflects
R2684	T4235	T4233	dobj	loss,reflects
R2685	T4236	T4235	prep	of,loss
R2686	T4237	T4238	compound	Bmpr1a,function
R2687	T4238	T4236	pobj	function,of
R2688	T4239	T4233	prep	in,reflects
R2689	T4240	T4241	det	the,fraction
R2690	T4241	T4239	pobj	fraction,in
R2691	T4242	T4241	prep	of,fraction
R2692	T4243	T4244	compound	ear,cells
R2693	T4244	T4242	pobj	cells,of
R2694	T4245	T4246	dep	that,express
R2695	T4246	T4241	relcl	express,fraction
R2696	T4247	T4248	det	the,transgene
R2697	T4248	T4246	dobj	transgene,express
R2698	T4249	T4250	compound	Gdf5,Cre
R2699	T4250	T4248	compound	Cre,transgene
R2700	T4251	T4250	punct	-,Cre
R2701	T4252	T4233	punct	.,reflects
R2702	T4254	T4255	amod	Most,mice
R2703	T4255	T4257	nsubj	mice,showed
R2704	T4256	T4255	compound	mutant,mice
R2705	T4258	T4257	advmod	also,showed
R2706	T4259	T4260	amod	soft,tissue
R2707	T4260	T4261	compound	tissue,syndactyly
R2708	T4261	T4257	dobj	syndactyly,showed
R2709	T4262	T4261	cc	or,syndactyly
R2710	T4263	T4261	conj	retention,syndactyly
R2711	T4264	T4263	prep	of,retention
R2712	T4265	T4264	pobj	webbing,of
R2713	T4266	T4265	prep	between,webbing
R2714	T4267	T4268	det	the,digits
R2715	T4268	T4266	pobj	digits,between
R2716	T4269	T4268	amod	first,digits
R2717	T4270	T4269	cc	and,first
R2718	T4271	T4269	conj	second,first
R2719	T4272	T4268	prep	of,digits
R2720	T4273	T4274	poss	their,feet
R2721	T4274	T4272	pobj	feet,of
R2722	T4275	T4261	punct	", ",syndactyly
R2723	T4276	T4277	det	a,phenotype
R2724	T4277	T4261	appos	phenotype,syndactyly
R2725	T4278	T4279	dep	that,was
R2726	T4279	T4277	relcl	was,phenotype
R2727	T4280	T4281	advmod	more,frequent
R2728	T4281	T4279	acomp	frequent,was
R2729	T4282	T4281	cc	and,frequent
R2730	T4283	T4284	advmod	more,severe
R2731	T4284	T4281	conj	severe,frequent
R2732	T4285	T4279	prep	in,was
R2733	T4286	T4287	det	the,forelimbs
R2734	T4287	T4285	pobj	forelimbs,in
R2735	T4288	T4289	punct	(,220
R2736	T4289	T4279	parataxis	220,was
R2737	T4290	T4289	quantmod	201,220
R2738	T4291	T4289	quantmod	of,220
R2739	T4292	T4289	punct	", ",220
R2740	T4293	T4289	cc	or,220
R2741	T4294	T4295	nummod	91,%
R2742	T4295	T4289	conj	%,220
R2743	T4296	T4289	punct	", ",220
R2744	T4297	T4289	prep	of,220
R2745	T4298	T4297	pobj	forefeet,of
R2746	T4299	T4289	cc	and,220
R2747	T4300	T4301	quantmod	109,220
R2748	T4301	T4289	conj	220,220
R2749	T4302	T4301	quantmod	of,220
R2750	T4303	T4301	punct	", ",220
R2751	T4304	T4301	cc	or,220
R2752	T4305	T4306	nummod	50,%
R2753	T4306	T4301	conj	%,220
R2754	T4307	T4301	punct	", ",220
R2755	T4308	T4301	prep	of,220
R2756	T4309	T4308	pobj	hindfeet,of
R2757	T4310	T4289	punct	),220
R2758	T4311	T4257	punct	.,showed
R2759	T4313	T4314	advmod	Finally,showed
R2760	T4315	T4314	punct	", ",showed
R2761	T4316	T4317	compound	mutant,animals
R2762	T4317	T4314	nsubj	animals,showed
R2763	T4318	T4319	amod	obvious,changes
R2764	T4319	T4314	dobj	changes,showed
R2765	T4320	T4319	amod	skeletal,changes
R2766	T4321	T4314	prep	in,showed
R2767	T4322	T4323	amod	whole,mount
R2768	T4323	T4325	nmod	mount,preparations
R2769	T4324	T4323	punct	-,mount
R2770	T4325	T4321	pobj	preparations,in
R2771	T4326	T4325	amod	skeletal,preparations
R2772	T4327	T4314	punct	.,showed
R2773	T4329	T4330	prep	At,seemed
R2774	T4331	T4332	det	some,sites
R2775	T4332	T4329	pobj	sites,At
R2776	T4333	T4332	prep	in,sites
R2777	T4334	T4335	det	the,ankles
R2778	T4335	T4333	pobj	ankles,in
R2779	T4336	T4330	punct	", ",seemed
R2780	T4337	T4330	nsubj	joints,seemed
R2781	T4338	T4339	aux	to,be
R2782	T4339	T4330	xcomp	be,seemed
R2783	T4340	T4339	acomp	missing,be
R2784	T4341	T4339	advmod	entirely,be
R2785	T4342	T4339	punct	", ",be
R2786	T4343	T4339	prep	with,be
R2787	T4344	T4343	pobj	fusion,with
R2788	T4345	T4344	prep	of,fusion
R2789	T4346	T4345	pobj	bones,of
R2790	T4347	T4348	dep	that,be
R2791	T4348	T4346	relcl	be,bones
R2792	T4349	T4348	aux	would,be
R2793	T4350	T4348	advmod	normally,be
R2794	T4351	T4348	acomp	separate,be
R2795	T4352	T4330	punct	.,seemed
R2796	T4354	T4355	prep	For,fused
R2797	T4356	T4354	pobj	example,For
R2798	T4357	T4355	punct	", ",fused
R2799	T4358	T4359	det	the,tarsal
R2800	T4359	T4355	nsubjpass	tarsal,fused
R2801	T4360	T4359	amod	second,tarsal
R2802	T4361	T4359	amod	distal,tarsal
R2803	T4362	T4355	auxpass	was,fused
R2804	T4363	T4355	prep	to,fused
R2805	T4364	T4365	det	the,bone
R2806	T4365	T4363	pobj	bone,to
R2807	T4366	T4365	amod	central,bone
R2808	T4367	T4365	amod	tarsal,bone
R2809	T4368	T4355	prep	in,fused
R2810	T4369	T4370	det	every,animal
R2811	T4370	T4368	pobj	animal,in
R2812	T4371	T4372	amod	conditional,knockout
R2813	T4372	T4370	compound	knockout,animal
R2814	T4373	T4370	acl	examined,animal
R2815	T4374	T4375	punct	(,18
R2816	T4375	T4370	parataxis	18,animal
R2817	T4376	T4375	quantmod	18,18
R2818	T4377	T4375	quantmod	of,18
R2819	T4378	T4375	punct	),18
R2820	T4379	T4355	punct	", ",fused
R2821	T4380	T4381	det	a,phenotype
R2822	T4381	T4355	npadvmod	phenotype,fused
R2823	T4382	T4383	neg	not,observed
R2824	T4383	T4381	acl	observed,phenotype
R2825	T4384	T4383	prep	in,observed
R2826	T4385	T4384	pobj	controls,in
R2827	T4386	T4387	punct	(,18
R2828	T4387	T4383	parataxis	18,observed
R2829	T4388	T4387	quantmod	zero,18
R2830	T4389	T4387	quantmod	of,18
R2831	T4390	T4387	punct	),18
R2832	T4391	T4392	punct	(,Figure
R2833	T4392	T4355	parataxis	Figure,fused
R2834	T4393	T4392	nummod	3B,Figure
R2835	T4394	T4392	cc	and,Figure
R2836	T4395	T4392	conj	3C,Figure
R2837	T4396	T4392	punct	),Figure
R2838	T4397	T4355	punct	.,fused
R2839	T4399	T4400	prep	At,formed
R2840	T4401	T4402	amod	other,locations
R2841	T4402	T4399	pobj	locations,At
R2842	T4403	T4400	punct	", ",formed
R2843	T4404	T4400	nsubj	joints,formed
R2844	T4405	T4400	aux	had,formed
R2845	T4406	T4400	advmod	clearly,formed
R2846	T4407	T4400	cc	but,formed
R2847	T4408	T4400	conj	showed,formed
R2848	T4409	T4410	amod	dramatic,loss
R2849	T4410	T4408	dobj	loss,showed
R2850	T4411	T4410	prep	of,loss
R2851	T4412	T4411	pobj	staining,of
R2852	T4413	T4412	prep	with,staining
R2853	T4414	T4415	det	the,marker
R2854	T4415	T4413	pobj	marker,with
R2855	T4416	T4415	compound	cartilage,marker
R2856	T4417	T4415	compound	matrix,marker
R2857	T4418	T4419	amod	Alcian,blue
R2858	T4419	T4415	appos	blue,marker
R2859	T4420	T4421	punct	(,3B
R2860	T4421	T4408	parataxis	3B,showed
R2861	T4422	T4421	compound	Figure,3B
R2862	T4423	T4424	punct	–,3E
R2863	T4424	T4421	prep	3E,3B
R2864	T4425	T4421	punct	),3B
R2865	T4426	T4427	punct	(,data
R2866	T4427	T4408	meta	data,showed
R2867	T4428	T4427	amod	unpublished,data
R2868	T4429	T4427	punct	),data
R2869	T4430	T4400	punct	.,formed
R2870	T4432	T4433	amod	Normal,staining
R2871	T4433	T4436	nsubjpass	staining,seen
R2872	T4434	T4435	amod	Alcian,blue
R2873	T4435	T4433	compound	blue,staining
R2874	T4437	T4436	auxpass	was,seen
R2875	T4438	T4436	prep	in,seen
R2876	T4439	T4440	amod	non-articular,regions
R2877	T4440	T4438	pobj	regions,in
R2878	T4441	T4440	punct	", ",regions
R2879	T4442	T4443	amod	such,as
R2880	T4443	T4440	prep	as,regions
R2881	T4444	T4445	det	the,plate
R2882	T4445	T4443	pobj	plate,as
R2883	T4446	T4445	amod	cartilaginous,plate
R2884	T4447	T4445	compound	growth,plate
R2885	T4448	T4449	punct	(,asterisk
R2886	T4449	T4436	parataxis	asterisk,seen
R2887	T4450	T4451	nmod	Figure,3D
R2888	T4451	T4449	dep	3D,asterisk
R2889	T4452	T4451	cc	and,3D
R2890	T4453	T4451	conj	3E,3D
R2891	T4454	T4449	punct	", ",asterisk
R2892	T4455	T4449	punct	),asterisk
R2893	T4456	T4436	punct	.,seen
R2894	T4458	T4459	det	These,data
R2895	T4459	T4460	nsubj	data,suggest
R2896	T4461	T4462	mark	that,is
R2897	T4462	T4460	ccomp	is,suggest
R2898	T4463	T4464	compound	Bmpr1a,function
R2899	T4464	T4462	nsubj	function,is
R2900	T4465	T4462	acomp	required,is
R2901	T4466	T4462	prep	for,is
R2902	T4467	T4468	det	the,formation
R2903	T4468	T4466	pobj	formation,for
R2904	T4469	T4468	prep	of,formation
R2905	T4470	T4471	amod	specific,joints
R2906	T4471	T4469	pobj	joints,of
R2907	T4472	T4468	prep	in,formation
R2908	T4473	T4474	det	the,region
R2909	T4474	T4472	pobj	region,in
R2910	T4475	T4474	compound	ankle,region
R2911	T4476	T4466	cc	and,for
R2912	T4477	T4466	conj	for,for
R2913	T4478	T4479	preconj	either,generation
R2914	T4479	T4477	pobj	generation,for
R2915	T4480	T4479	cc	or,generation
R2916	T4481	T4479	conj	maintenance,generation
R2917	T4482	T4479	prep	of,generation
R2918	T4483	T4484	amod	articular,cartilage
R2919	T4484	T4482	pobj	cartilage,of
R2920	T4485	T4479	prep	in,generation
R2921	T4486	T4487	amod	most,joints
R2922	T4487	T4485	pobj	joints,in
R2923	T4488	T4487	amod	other,joints
R2924	T4489	T4487	prep	of,joints
R2925	T4490	T4491	det	the,limb
R2926	T4491	T4489	pobj	limb,of
R2927	T4492	T4460	punct	.,suggest
R2946	T4677	T4678	amod	Developmental,Origin
R2947	T4679	T4678	prep	of,Origin
R2948	T4680	T4681	compound	Webbing,Phenotype
R2949	T4681	T4679	pobj	Phenotype,of
R2950	T4683	T4684	amod	Interdigital,mesenchyme
R2951	T4684	T4685	nsubjpass	mesenchyme,eliminated
R2952	T4686	T4685	auxpass	is,eliminated
R2953	T4687	T4685	advmod	normally,eliminated
R2954	T4688	T4685	agent	by,eliminated
R2955	T4689	T4688	pobj	apoptosis,by
R2956	T4690	T4685	prep	during,eliminated
R2957	T4691	T4692	amod	embryonic,development
R2958	T4692	T4690	pobj	development,during
R2959	T4693	T4685	punct	", ",eliminated
R2960	T4694	T4695	det	a,process
R2961	T4695	T4685	npadvmod	process,eliminated
R2962	T4696	T4697	dep	that,stimulated
R2963	T4697	T4695	relcl	stimulated,process
R2964	T4698	T4697	aux	can,stimulated
R2965	T4699	T4697	auxpass	be,stimulated
R2966	T4700	T4697	agent	by,stimulated
R2967	T4701	T4702	compound	BMP,beads
R2968	T4702	T4700	pobj	beads,by
R2969	T4703	T4697	punct	", ",stimulated
R2970	T4704	T4697	conj	inhibited,stimulated
R2971	T4705	T4704	agent	by,inhibited
R2972	T4706	T4705	pobj	Noggin,by
R2973	T4707	T4704	punct	", ",inhibited
R2974	T4708	T4704	cc	or,inhibited
R2975	T4709	T4704	conj	blocked,inhibited
R2976	T4710	T4709	agent	by,blocked
R2977	T4711	T4710	pobj	overexpression,by
R2978	T4712	T4711	prep	of,overexpression
R2979	T4713	T4714	amod	dominant,negative
R2980	T4714	T4716	nmod	negative,receptors
R2981	T4715	T4714	punct	-,negative
R2982	T4716	T4712	pobj	receptors,of
R2983	T4717	T4716	compound	BMP,receptors
R2984	T4718	T4719	punct	(,Garcia
R2985	T4719	T4685	meta	Garcia,eliminated
R2986	T4720	T4719	punct	-,Garcia
R2987	T4721	T4719	nmod	Martinez,Garcia
R2988	T4722	T4719	nmod	et,Garcia
R2989	T4723	T4719	nmod	al.,Garcia
R2990	T4724	T4719	nummod	1993,Garcia
R2991	T4725	T4719	punct	;,Garcia
R2992	T4726	T4719	conj	Yokouchi,Garcia
R2993	T4727	T4726	nmod	et,Yokouchi
R2994	T4728	T4726	nmod	al.,Yokouchi
R2995	T4729	T4726	nummod	1996,Yokouchi
R2996	T4730	T4726	punct	;,Yokouchi
R2997	T4731	T4726	conj	Zou,Yokouchi
R2998	T4732	T4731	cc	and,Zou
R2999	T4733	T4731	conj	Niswander,Zou
R3000	T4734	T4733	nummod	1996,Niswander
R3001	T4735	T4733	punct	;,Niswander
R3002	T4736	T4733	conj	Guha,Niswander
R3003	T4737	T4736	nmod	et,Guha
R3004	T4738	T4736	nmod	al.,Guha
R3005	T4739	T4736	nummod	2002,Guha
R3006	T4740	T4736	punct	),Guha
R3007	T4741	T4685	punct	.,eliminated
R3008	T4743	T4744	nsubj	Limbs,showed
R3009	T4745	T4743	prep	of,Limbs
R3010	T4746	T4747	compound	Gdf5,Cre
R3011	T4747	T4749	compound	Cre,Bmpr1afloxP
R3012	T4748	T4747	punct	-,Cre
R3013	T4749	T4751	npadvmod	Bmpr1afloxP,mutant
R3014	T4750	T4749	punct	/,Bmpr1afloxP
R3015	T4751	T4752	amod	mutant,embryos
R3016	T4752	T4745	pobj	embryos,of
R3017	T4753	T4754	amod	obvious,retention
R3018	T4754	T4744	dobj	retention,showed
R3019	T4755	T4754	prep	of,retention
R3020	T4756	T4757	amod	interdigital,webbing
R3021	T4757	T4755	pobj	webbing,of
R3022	T4758	T4757	prep	between,webbing
R3023	T4759	T4760	det	the,digits
R3024	T4760	T4758	pobj	digits,between
R3025	T4761	T4760	amod	first,digits
R3026	T4762	T4761	cc	and,first
R3027	T4763	T4761	conj	second,first
R3028	T4764	T4761	punct	", ",first
R3029	T4765	T4761	cc	but,first
R3030	T4766	T4765	neg	not,but
R3031	T4767	T4761	conj	other,first
R3032	T4768	T4760	punct	", ",digits
R3033	T4769	T4760	prep	of,digits
R3034	T4770	T4771	compound	E14.5,forelimbs
R3035	T4771	T4769	pobj	forelimbs,of
R3036	T4772	T4773	punct	(,Figure
R3037	T4773	T4760	parataxis	Figure,digits
R3038	T4774	T4773	nummod	2A,Figure
R3039	T4775	T4773	cc	and,Figure
R3040	T4776	T4773	conj	2B,Figure
R3041	T4777	T4773	punct	),Figure
R3042	T4778	T4744	punct	", ",showed
R3043	T4779	T4780	det	a,pattern
R3044	T4780	T4744	npadvmod	pattern,showed
R3045	T4781	T4782	dep	that,corresponds
R3046	T4782	T4780	relcl	corresponds,pattern
R3047	T4783	T4782	prep	to,corresponds
R3048	T4784	T4785	det	the,presence
R3049	T4785	T4783	pobj	presence,to
R3050	T4786	T4785	cc	or,presence
R3051	T4787	T4785	conj	absence,presence
R3052	T4788	T4785	prep	of,presence
R3053	T4789	T4788	pobj	webbing,of
R3054	T4790	T4789	acl	seen,webbing
R3055	T4791	T4790	prep	in,seen
R3056	T4792	T4793	det	the,limb
R3057	T4793	T4791	pobj	limb,in
R3058	T4794	T4793	compound	adult,limb
R3059	T4795	T4744	punct	.,showed
R3060	T4797	T4798	nsubj	They,showed
R3061	T4799	T4798	advmod	also,showed
R3062	T4800	T4801	amod	excess,tissue
R3063	T4801	T4798	dobj	tissue,showed
R3064	T4802	T4798	prep	on,showed
R3065	T4803	T4804	det	the,margin
R3066	T4804	T4802	pobj	margin,on
R3067	T4805	T4804	amod	posterior,margin
R3068	T4806	T4804	prep	of,margin
R3069	T4807	T4808	det	the,digit
R3070	T4808	T4806	pobj	digit,of
R3071	T4809	T4808	amod	fifth,digit
R3072	T4810	T4811	punct	(,arrow
R3073	T4811	T4798	parataxis	arrow,showed
R3074	T4812	T4811	dep	Figure,arrow
R3075	T4813	T4812	nummod	2B,Figure
R3076	T4814	T4811	punct	", ",arrow
R3077	T4815	T4811	punct	),arrow
R3078	T4816	T4798	punct	.,showed
R3079	T4818	T4819	nsubj	Analysis,showed
R3080	T4820	T4818	prep	of,Analysis
R3081	T4821	T4822	compound	LACZ,expression
R3082	T4822	T4820	pobj	expression,of
R3083	T4823	T4818	prep	in,Analysis
R3084	T4824	T4825	compound	Gdf5,Cre
R3085	T4825	T4827	compound	Cre,R26R
R3086	T4826	T4825	punct	-,Cre
R3087	T4827	T4829	compound	R26R,embryos
R3088	T4828	T4827	punct	/,R26R
R3089	T4829	T4823	pobj	embryos,in
R3090	T4830	T4829	compound	reporter,embryos
R3091	T4831	T4832	mark	that,occurred
R3092	T4832	T4819	ccomp	occurred,showed
R3093	T4833	T4834	npadvmod	Cre,mediated
R3094	T4834	T4836	amod	mediated,recombination
R3095	T4835	T4834	punct	-,mediated
R3096	T4836	T4832	nsubj	recombination,occurred
R3097	T4837	T4832	aux	has,occurred
R3098	T4838	T4832	prep	by,occurred
R3099	T4839	T4838	pobj	E13.5,by
R3100	T4840	T4832	prep	in,occurred
R3101	T4841	T4842	det	the,joints
R3102	T4842	T4840	pobj	joints,in
R3103	T4843	T4844	amod	metacarpal,phalangeal
R3104	T4844	T4842	amod	phalangeal,joints
R3105	T4845	T4844	punct	-,phalangeal
R3106	T4846	T4840	punct	", ",in
R3107	T4847	T4840	cc	and,in
R3108	T4848	T4840	conj	in,in
R3109	T4849	T4850	det	the,region
R3110	T4850	T4848	pobj	region,in
R3111	T4851	T4850	amod	interdigital,region
R3112	T4852	T4850	prep	between,region
R3113	T4853	T4854	det	the,digits
R3114	T4854	T4852	pobj	digits,between
R3115	T4855	T4854	amod	first,digits
R3116	T4856	T4855	cc	and,first
R3117	T4857	T4855	conj	second,first
R3118	T4858	T4855	punct	", ",first
R3119	T4859	T4855	cc	but,first
R3120	T4860	T4859	neg	not,but
R3121	T4861	T4855	conj	other,first
R3122	T4862	T4854	punct	", ",digits
R3123	T4863	T4819	punct	.,showed
R3124	T4865	T4866	prep	In,seen
R3125	T4867	T4865	pobj	addition,In
R3126	T4868	T4866	punct	", ",seen
R3127	T4869	T4870	det	a,domain
R3128	T4870	T4866	nsubjpass	domain,seen
R3129	T4871	T4870	prep	of,domain
R3130	T4872	T4871	pobj	recombination,of
R3131	T4873	T4872	cc	and,recombination
R3132	T4874	T4872	conj	expression,recombination
R3133	T4875	T4872	prep	of,recombination
R3134	T4876	T4875	pobj	LACZ,of
R3135	T4877	T4866	auxpass	is,seen
R3136	T4878	T4866	advmod	also,seen
R3137	T4879	T4866	advmod	reproducibly,seen
R3138	T4880	T4866	prep	in,seen
R3139	T4881	T4882	det	the,half
R3140	T4882	T4880	pobj	half,in
R3141	T4883	T4882	amod	posterior,half
R3142	T4884	T4882	prep	of,half
R3143	T4885	T4886	det	the,digit
R3144	T4886	T4884	pobj	digit,of
R3145	T4887	T4886	amod	fifth,digit
R3146	T4888	T4889	punct	(,Figure
R3147	T4889	T4866	parataxis	Figure,seen
R3148	T4890	T4889	nummod	2C,Figure
R3149	T4891	T4889	punct	),Figure
R3150	T4892	T4866	punct	.,seen
R3151	T4894	T4895	amod	Terminal,labeling
R3152	T4895	T4904	nmod	labeling,staining
R3153	T4896	T4897	compound	deoxynucleotidyl,transferase
R3154	T4897	T4898	npadvmod	transferase,mediated
R3155	T4898	T4895	amod	mediated,labeling
R3156	T4899	T4898	punct	–,mediated
R3157	T4900	T4901	nmod	deoxyuridine,triphosphate
R3158	T4901	T4895	nmod	triphosphate,labeling
R3159	T4902	T4903	nmod	nick,end
R3160	T4903	T4895	nmod	end,labeling
R3161	T4904	T4908	nsubj	staining,showed
R3162	T4905	T4906	punct	(,TUNEL
R3163	T4906	T4895	appos	TUNEL,labeling
R3164	T4907	T4906	punct	),TUNEL
R3165	T4909	T4904	prep	of,staining
R3166	T4910	T4911	amod	interdigital,mesenchyme
R3167	T4911	T4909	pobj	mesenchyme,of
R3168	T4912	T4911	prep	between,mesenchyme
R3169	T4913	T4914	det	the,digits
R3170	T4914	T4912	pobj	digits,between
R3171	T4915	T4914	amod	first,digits
R3172	T4916	T4915	cc	and,first
R3173	T4917	T4915	conj	second,first
R3174	T4918	T4919	punct	(,Figure
R3175	T4919	T4914	parataxis	Figure,digits
R3176	T4920	T4919	nummod	2D,Figure
R3177	T4921	T4919	cc	and,Figure
R3178	T4922	T4919	conj	2E,Figure
R3179	T4923	T4919	punct	),Figure
R3180	T4924	T4914	cc	and,digits
R3181	T4925	T4926	det	the,digit
R3182	T4926	T4914	conj	digit,digits
R3183	T4927	T4926	amod	fifth,digit
R3184	T4928	T4914	acl	flanking,digits
R3185	T4929	T4928	dobj	mesenchyme,flanking
R3186	T4930	T4931	det	a,number
R3187	T4931	T4908	dobj	number,showed
R3188	T4932	T4931	amod	decreased,number
R3189	T4933	T4931	prep	of,number
R3190	T4934	T4935	amod	dying,cells
R3191	T4935	T4933	pobj	cells,of
R3192	T4936	T4908	prep	in,showed
R3193	T4937	T4938	det	the,regions
R3194	T4938	T4936	pobj	regions,in
R3195	T4939	T4940	advmod	where,retained
R3196	T4940	T4938	relcl	retained,regions
R3197	T4941	T4942	amod	excess,tissue
R3198	T4942	T4940	nsubjpass	tissue,retained
R3199	T4943	T4940	auxpass	is,retained
R3200	T4944	T4940	prep	in,retained
R3201	T4945	T4946	det	the,limbs
R3202	T4946	T4944	pobj	limbs,in
R3203	T4947	T4946	compound	mutant,limbs
R3204	T4948	T4908	punct	.,showed
R3205	T4950	T4951	nsubjpass	Numbers,elevated
R3206	T4952	T4950	prep	of,Numbers
R3207	T4953	T4954	amod	phosphorylated,H3
R3208	T4954	T4956	npadvmod	H3,labeled
R3209	T4955	T4954	compound	histone,H3
R3210	T4956	T4958	amod	labeled,cells
R3211	T4957	T4956	punct	-,labeled
R3212	T4958	T4952	pobj	cells,of
R3213	T4959	T4958	amod	proliferating,cells
R3214	T4960	T4951	auxpass	were,elevated
R3215	T4961	T4951	advmod	also,elevated
R3216	T4962	T4951	prep	in,elevated
R3217	T4963	T4964	det	these,regions
R3218	T4964	T4962	pobj	regions,in
R3219	T4965	T4966	punct	(,Figure
R3220	T4966	T4951	parataxis	Figure,elevated
R3221	T4967	T4966	nummod	2F,Figure
R3222	T4968	T4966	punct	),Figure
R3223	T4969	T4951	punct	.,elevated
R3224	T4971	T4972	amod	Most,cells
R3225	T4972	T4973	nsubj	cells,expressed
R3226	T4974	T4972	acl	found,cells
R3227	T4975	T4974	prep	in,found
R3228	T4976	T4977	det	the,region
R3229	T4977	T4975	pobj	region,in
R3230	T4978	T4977	amod	webbed,region
R3231	T4979	T4977	prep	between,region
R3232	T4980	T4981	det	the,digits
R3233	T4981	T4979	pobj	digits,between
R3234	T4982	T4981	amod	first,digits
R3235	T4983	T4982	cc	and,first
R3236	T4984	T4982	conj	second,first
R3237	T4985	T4974	prep	at,found
R3238	T4986	T4985	pobj	E15.5,at
R3239	T4987	T4973	advmod	strongly,expressed
R3240	T4988	T4973	dobj	LACZ,expressed
R3241	T4989	T4973	prep	in,expressed
R3242	T4990	T4991	compound	Gdf5,Cre
R3243	T4991	T4993	compound	Cre,Bmpr1afloxP
R3244	T4992	T4991	punct	-,Cre
R3245	T4993	T4995	compound	Bmpr1afloxP,embryos
R3246	T4994	T4993	punct	/,Bmpr1afloxP
R3247	T4995	T4989	pobj	embryos,in
R3248	T4996	T4995	compound	mutant,embryos
R3249	T4997	T4998	punct	(,Figure
R3250	T4998	T4973	parataxis	Figure,expressed
R3251	T4999	T4998	nummod	2H,Figure
R3252	T5000	T4998	punct	),Figure
R3253	T5001	T4973	punct	.,expressed
R3254	T5003	T5004	det	These,data
R3255	T5004	T5005	nsubj	data,suggest
R3256	T5006	T5007	mark	that,blocks
R3257	T5007	T5005	advcl	blocks,suggest
R3258	T5008	T5009	amod	regional,loss
R3259	T5009	T5007	nsubj	loss,blocks
R3260	T5010	T5009	prep	of,loss
R3261	T5011	T5012	compound	BMPR1A,signaling
R3262	T5012	T5010	pobj	signaling,of
R3263	T5013	T5012	compound	receptor,signaling
R3264	T5014	T5015	amod	programmed,death
R3265	T5015	T5007	dobj	death,blocks
R3266	T5016	T5015	compound	cell,death
R3267	T5017	T5007	prep	in,blocks
R3268	T5018	T5019	amod	interdigital,mesenchyme
R3269	T5019	T5017	pobj	mesenchyme,in
R3270	T5020	T5007	punct	", ",blocks
R3271	T5021	T5007	cc	and,blocks
R3272	T5022	T5023	mark	that,survive
R3273	T5023	T5007	conj	survive,blocks
R3274	T5024	T5025	det	the,cells
R3275	T5025	T5023	nsubj	cells,survive
R3276	T5026	T5025	amod	recombined,cells
R3277	T5027	T5023	cc	and,survive
R3278	T5028	T5023	conj	proliferate,survive
R3279	T5029	T5028	prep	in,proliferate
R3280	T5030	T5031	det	the,absence
R3281	T5031	T5029	pobj	absence,in
R3282	T5032	T5031	prep	of,absence
R3283	T5033	T5034	compound	BMPR1A,signaling
R3284	T5034	T5032	pobj	signaling,of
R3285	T5035	T5005	punct	.,suggest
R3286	T5157	T5156	prep	of,Failure
R3287	T5158	T5159	amod	Early,Formation
R3288	T5159	T5157	pobj	Formation,of
R3289	T5160	T5159	compound	Joint,Formation
R3290	T5161	T5156	prep	in,Failure
R3291	T5162	T5163	compound	Ankle,Regions
R3292	T5163	T5161	pobj	Regions,in
R3293	T5165	T5166	det	The,gene
R3294	T5166	T5168	nsubjpass	gene,expressed
R3295	T5167	T5166	compound	Bmpr1a,gene
R3296	T5169	T5168	auxpass	is,expressed
R3297	T5170	T5168	prep	in,expressed
R3298	T5171	T5172	det	the,region
R3299	T5172	T5170	pobj	region,in
R3300	T5173	T5172	compound	interzone,region
R3301	T5174	T5172	prep	of,region
R3302	T5175	T5176	amod	developing,joints
R3303	T5176	T5174	pobj	joints,of
R3304	T5177	T5168	prep	at,expressed
R3305	T5178	T5177	pobj	E13.5,at
R3306	T5179	T5180	punct	(,Baur
R3307	T5180	T5168	meta	Baur,expressed
R3308	T5181	T5180	nmod	et,Baur
R3309	T5182	T5180	nmod	al.,Baur
R3310	T5183	T5180	nummod	2000,Baur
R3311	T5184	T5180	punct	),Baur
R3312	T5185	T5168	punct	.,expressed
R3313	T5187	T5188	advmod	In,situ
R3314	T5188	T5189	amod	situ,hybridization
R3315	T5189	T5190	nsubj	hybridization,showed
R3316	T5191	T5192	mark	that,expressed
R3317	T5192	T5190	ccomp	expressed,showed
R3318	T5193	T5194	det	the,gene
R3319	T5194	T5192	nsubjpass	gene,expressed
R3320	T5195	T5192	auxpass	is,expressed
R3321	T5196	T5192	advmod	also,expressed
R3322	T5197	T5192	prep	in,expressed
R3323	T5198	T5199	det	the,interzones
R3324	T5199	T5197	pobj	interzones,in
R3325	T5200	T5199	prep	of,interzones
R3326	T5201	T5202	compound	ankle,joints
R3327	T5202	T5200	pobj	joints,of
R3328	T5203	T5199	cc	and,interzones
R3329	T5204	T5205	amod	prospective,regions
R3330	T5205	T5199	conj	regions,interzones
R3331	T5206	T5207	amod	articular,cartilage
R3332	T5207	T5205	compound	cartilage,regions
R3333	T5208	T5205	prep	of,regions
R3334	T5209	T5210	compound	digit,joints
R3335	T5210	T5208	pobj	joints,of
R3336	T5211	T5192	prep	at,expressed
R3337	T5212	T5211	pobj	E15.5,at
R3338	T5213	T5214	punct	(,Figure
R3339	T5214	T5190	parataxis	Figure,showed
R3340	T5215	T5214	nummod	4,Figure
R3341	T5216	T5214	punct	),Figure
R3342	T5217	T5190	punct	.,showed
R3343	T5219	T5220	compound	LACZ,staining
R3344	T5220	T5221	nsubj	staining,indicated
R3345	T5222	T5223	mark	that,begins
R3346	T5223	T5221	ccomp	begins,indicated
R3347	T5224	T5225	npadvmod	Cre,mediated
R3348	T5225	T5227	amod	mediated,recombination
R3349	T5226	T5225	punct	-,mediated
R3350	T5227	T5223	nsubj	recombination,begins
R3351	T5228	T5229	aux	to,occur
R3352	T5229	T5223	xcomp	occur,begins
R3353	T5230	T5229	prep	in,occur
R3354	T5231	T5232	compound	ankle,joints
R3355	T5232	T5230	pobj	joints,in
R3356	T5233	T5229	prep	around,occur
R3357	T5234	T5233	pobj	E14.5,around
R3358	T5235	T5223	punct	", ",begins
R3359	T5236	T5223	cc	and,begins
R3360	T5237	T5223	conj	is,begins
R3361	T5238	T5237	acomp	extensive,is
R3362	T5239	T5237	prep	by,is
R3363	T5240	T5239	pobj	E15.5,by
R3364	T5241	T5242	punct	(,Figure
R3365	T5242	T5221	parataxis	Figure,indicated
R3366	T5243	T5242	nummod	4G,Figure
R3367	T5244	T5242	cc	and,Figure
R3368	T5245	T5242	conj	4J,Figure
R3369	T5246	T5242	punct	),Figure
R3370	T5247	T5248	punct	(,data
R3371	T5248	T5221	meta	data,indicated
R3372	T5249	T5248	amod	unpublished,data
R3373	T5250	T5248	punct	),data
R3374	T5251	T5221	punct	.,indicated
R3375	T5253	T5254	prep	In,seen
R3376	T5255	T5256	det	the,regions
R3377	T5256	T5253	pobj	regions,In
R3378	T5257	T5258	compound	ankle,joint
R3379	T5258	T5256	compound	joint,regions
R3380	T5259	T5260	dep	that,fused
R3381	T5260	T5256	relcl	fused,regions
R3382	T5261	T5260	auxpass	were,fused
R3383	T5262	T5260	advmod	obviously,fused
R3384	T5263	T5260	prep	in,fused
R3385	T5264	T5265	amod	postnatal,animals
R3386	T5265	T5263	pobj	animals,in
R3387	T5266	T5265	compound	mutant,animals
R3388	T5267	T5254	punct	", ",seen
R3389	T5268	T5254	nsubjpass	alterations,seen
R3390	T5269	T5268	prep	in,alterations
R3391	T5270	T5271	amod	early,expression
R3392	T5271	T5269	pobj	expression,in
R3393	T5272	T5273	compound	joint,marker
R3394	T5273	T5271	compound	marker,expression
R3395	T5274	T5254	aux	could,seen
R3396	T5275	T5254	advmod	also,seen
R3397	T5276	T5254	auxpass	be,seen
R3398	T5277	T5254	prep	by,seen
R3399	T5278	T5277	pobj	E15.5,by
R3400	T5279	T5254	punct	.,seen
R3401	T5281	T5282	prep	At,expressed
R3402	T5283	T5284	det	this,stage
R3403	T5284	T5281	pobj	stage,At
R3404	T5285	T5282	punct	", ",expressed
R3405	T5286	T5287	det	the,gene
R3406	T5287	T5282	nsubjpass	gene,expressed
R3407	T5288	T5287	compound	Gdf5,gene
R3408	T5289	T5282	auxpass	is,expressed
R3409	T5290	T5282	advmod	normally,expressed
R3410	T5291	T5282	prep	in,expressed
R3411	T5292	T5291	pobj	stripes,in
R3412	T5293	T5294	dep	that,mark
R3413	T5294	T5292	relcl	mark,stripes
R3414	T5295	T5296	det	the,sites
R3415	T5296	T5294	dobj	sites,mark
R3416	T5297	T5296	prep	of,sites
R3417	T5298	T5299	compound	joint,formation
R3418	T5299	T5297	pobj	formation,of
R3419	T5300	T5301	punct	(,Figure
R3420	T5301	T5282	parataxis	Figure,expressed
R3421	T5302	T5301	nummod	4F,Figure
R3422	T5303	T5301	punct	),Figure
R3423	T5304	T5282	punct	", ",expressed
R3424	T5305	T5282	cc	and,expressed
R3425	T5306	T5307	det	the,gene
R3426	T5307	T5308	nsubjpass	gene,regulated
R3427	T5308	T5282	conj	regulated,expressed
R3428	T5309	T5307	prep	for,gene
R3429	T5310	T5311	det	the,protein
R3430	T5311	T5309	pobj	protein,for
R3431	T5312	T5311	amod	major,protein
R3432	T5313	T5311	compound	collagen,protein
R3433	T5314	T5311	prep	of,protein
R3434	T5315	T5316	compound	cartilage,matrix
R3435	T5316	T5314	pobj	matrix,of
R3436	T5317	T5307	punct	(,gene
R3437	T5318	T5307	appos	Col2a1,gene
R3438	T5319	T5307	punct	),gene
R3439	T5320	T5308	auxpass	is,regulated
R3440	T5321	T5308	advmod	down,regulated
R3441	T5322	T5308	punct	-,regulated
R3442	T5323	T5308	prep	in,regulated
R3443	T5324	T5325	det	the,region
R3444	T5325	T5323	pobj	region,in
R3445	T5326	T5325	compound	interzone,region
R3446	T5327	T5328	punct	(,Figure
R3447	T5328	T5308	parataxis	Figure,regulated
R3448	T5329	T5328	nummod	4E,Figure
R3449	T5330	T5328	punct	),Figure
R3450	T5331	T5308	punct	.,regulated
R3451	T5333	T5334	prep	In,extended
R3452	T5335	T5333	pobj	contrast,In
R3453	T5336	T5334	punct	", ",extended
R3454	T5337	T5338	compound	Col2a1,staining
R3455	T5338	T5334	nsubj	staining,extended
R3456	T5339	T5334	advmod	completely,extended
R3457	T5340	T5334	prep	through,extended
R3458	T5341	T5342	det	the,region
R3459	T5342	T5340	pobj	region,through
R3460	T5343	T5342	compound	joint,region
R3461	T5344	T5342	prep	between,region
R3462	T5345	T5346	det	the,tarsal
R3463	T5346	T5344	pobj	tarsal,between
R3464	T5347	T5346	amod	second,tarsal
R3465	T5348	T5347	cc	and,second
R3466	T5349	T5347	conj	central,second
R3467	T5350	T5346	prep	of,tarsal
R3468	T5351	T5352	compound	Gdf5,Cre
R3469	T5352	T5354	compound	Cre,Bmpr1afloxP
R3470	T5353	T5352	punct	-,Cre
R3471	T5354	T5356	compound	Bmpr1afloxP,mutants
R3472	T5355	T5354	punct	/,Bmpr1afloxP
R3473	T5356	T5350	pobj	mutants,of
R3474	T5357	T5358	punct	(,arrow
R3475	T5358	T5334	parataxis	arrow,extended
R3476	T5359	T5358	dep	Figure,arrow
R3477	T5360	T5359	nummod	4H,Figure
R3478	T5361	T5358	punct	", ",arrow
R3479	T5362	T5358	amod	black,arrow
R3480	T5363	T5358	punct	),arrow
R3481	T5364	T5334	punct	", ",extended
R3482	T5365	T5334	cc	and,extended
R3483	T5366	T5367	compound	Gdf5,expression
R3484	T5367	T5368	nsubjpass	expression,seen
R3485	T5368	T5334	conj	seen,extended
R3486	T5369	T5368	auxpass	was,seen
R3487	T5370	T5371	advmod	only,as
R3488	T5371	T5368	prep	as,seen
R3489	T5372	T5373	det	a,notch
R3490	T5373	T5371	pobj	notch,as
R3491	T5374	T5373	amod	small,notch
R3492	T5375	T5373	acl	extending,notch
R3493	T5376	T5375	prep	into,extending
R3494	T5377	T5378	advmod	where,forming
R3495	T5378	T5376	pcomp	forming,into
R3496	T5379	T5380	det	the,joint
R3497	T5380	T5378	nsubj	joint,forming
R3498	T5381	T5378	aux	should,forming
R3499	T5382	T5378	aux	be,forming
R3500	T5383	T5384	punct	(,bracket
R3501	T5384	T5368	parataxis	bracket,seen
R3502	T5385	T5384	dep	Figure,bracket
R3503	T5386	T5385	nummod	4I,Figure
R3504	T5387	T5384	punct	", ",bracket
R3505	T5388	T5384	punct	),bracket
R3506	T5389	T5368	punct	.,seen
R3507	T5391	T5392	det	These,data
R3508	T5392	T5393	nsubj	data,suggest
R3509	T5394	T5395	mark	that,are
R3510	T5395	T5393	ccomp	are,suggest
R3511	T5396	T5397	det	the,fusions
R3512	T5397	T5395	nsubj	fusions,are
R3513	T5398	T5397	acl	seen,fusions
R3514	T5399	T5398	prep	between,seen
R3515	T5400	T5401	compound	ankle,bones
R3516	T5401	T5399	pobj	bones,between
R3517	T5402	T5398	prep	in,seen
R3518	T5403	T5404	amod	postnatal,skeletons
R3519	T5404	T5402	pobj	skeletons,in
R3520	T5405	T5404	compound	mutant,skeletons
R3521	T5406	T5407	det	the,result
R3522	T5407	T5395	attr	result,are
R3523	T5408	T5407	prep	of,result
R3524	T5409	T5410	amod	incomplete,segmentation
R3525	T5410	T5408	pobj	segmentation,of
R3526	T5411	T5410	prep	of,segmentation
R3527	T5412	T5413	amod	skeletal,precursors
R3528	T5413	T5411	pobj	precursors,of
R3529	T5414	T5410	prep	during,segmentation
R3530	T5415	T5416	amod	embryonic,development
R3531	T5416	T5414	pobj	development,during
R3532	T5417	T5410	punct	", ",segmentation
R3533	T5418	T5419	det	a,defect
R3534	T5419	T5410	appos	defect,segmentation
R3535	T5420	T5419	acl	confined,defect
R3536	T5421	T5420	prep	to,confined
R3537	T5422	T5423	det	some,locations
R3538	T5423	T5421	pobj	locations,to
R3539	T5424	T5423	prep	in,locations
R3540	T5425	T5426	det	the,ankle
R3541	T5426	T5424	pobj	ankle,in
R3542	T5427	T5393	punct	.,suggest
R3551	T5887	T5888	aux	to,Maintain
R3552	T5888	T5886	acl	Maintain,Failure
R3553	T5889	T5890	amod	Articular,Cartilage
R3554	T5890	T5888	dobj	Cartilage,Maintain
R3555	T5891	T5888	prep	in,Maintain
R3556	T5892	T5893	amod	Other,Joints
R3557	T5893	T5891	pobj	Joints,in
R3558	T5895	T5896	prep	In,occurred
R3559	T5897	T5898	amod	most,joints
R3560	T5898	T5895	pobj	joints,In
R3561	T5899	T5898	prep	of,joints
R3562	T5900	T5901	nmod	Bmpr1a,knockout
R3563	T5901	T5903	compound	knockout,mice
R3564	T5902	T5901	amod	conditional,knockout
R3565	T5903	T5899	pobj	mice,of
R3566	T5904	T5896	punct	", ",occurred
R3567	T5905	T5906	amod	embryonic,segmentation
R3568	T5906	T5896	nsubj	segmentation,occurred
R3569	T5907	T5906	prep	of,segmentation
R3570	T5908	T5909	amod	skeletal,precursors
R3571	T5909	T5907	pobj	precursors,of
R3572	T5910	T5896	advmod	normally,occurred
R3573	T5911	T5896	punct	.,occurred
R3574	T5913	T5914	mark	Although,seen
R3575	T5914	T5922	advcl	seen,seen
R3576	T5915	T5916	compound	Gdf5,Cre
R3577	T5916	T5918	npadvmod	Cre,mediated
R3578	T5917	T5916	punct	-,Cre
R3579	T5918	T5920	amod	mediated,recombination
R3580	T5919	T5918	punct	-,mediated
R3581	T5920	T5914	nsubjpass	recombination,seen
R3582	T5921	T5914	auxpass	was,seen
R3583	T5923	T5924	advmod	as,early
R3584	T5924	T5914	advmod	early,seen
R3585	T5925	T5924	prep	as,early
R3586	T5926	T5925	pobj	E13.5,as
R3587	T5927	T5914	prep	in,seen
R3588	T5928	T5929	compound	digit,regions
R3589	T5929	T5927	pobj	regions,in
R3590	T5930	T5929	compound	interzone,regions
R3591	T5931	T5932	punct	(,see
R3592	T5932	T5914	parataxis	see,seen
R3593	T5933	T5932	dobj	Figure,see
R3594	T5934	T5933	nummod	2C,Figure
R3595	T5935	T5932	punct	),see
R3596	T5936	T5922	punct	", ",seen
R3597	T5937	T5938	det	no,changes
R3598	T5938	T5922	nsubjpass	changes,seen
R3599	T5939	T5938	prep	in,changes
R3600	T5940	T5941	compound	cell,death
R3601	T5941	T5939	pobj	death,in
R3602	T5942	T5941	cc	or,death
R3603	T5943	T5944	compound	cell,proliferation
R3604	T5944	T5941	conj	proliferation,death
R3605	T5945	T5922	aux	could,seen
R3606	T5946	T5922	auxpass	be,seen
R3607	T5947	T5922	prep	in,seen
R3608	T5948	T5949	det	the,joints
R3609	T5949	T5947	pobj	joints,in
R3610	T5950	T5951	amod	metacarpal,phalangeal
R3611	T5951	T5949	amod	phalangeal,joints
R3612	T5952	T5951	punct	-,phalangeal
R3613	T5953	T5951	cc	or,phalangeal
R3614	T5954	T5955	amod	metatarsal,phalangeal
R3615	T5955	T5951	conj	phalangeal,phalangeal
R3616	T5956	T5955	punct	-,phalangeal
R3617	T5957	T5922	prep	at,seen
R3618	T5958	T5957	pobj	E13.5,at
R3619	T5959	T5958	cc	or,E13.5
R3620	T5960	T5958	conj	E14.5,E13.5
R3621	T5961	T5962	punct	(,data
R3622	T5962	T5922	meta	data,seen
R3623	T5963	T5962	amod	unpublished,data
R3624	T5964	T5962	punct	),data
R3625	T5965	T5922	punct	.,seen
R3626	T5967	T5968	advmod	Similarly,seen
R3627	T5969	T5968	punct	", ",seen
R3628	T5970	T5971	mark	although,seen
R3629	T5971	T5968	advcl	seen,seen
R3630	T5972	T5973	amod	clear,expression
R3631	T5973	T5971	nsubjpass	expression,seen
R3632	T5974	T5973	compound	LACZ,expression
R3633	T5975	T5971	auxpass	was,seen
R3634	T5976	T5971	prep	by,seen
R3635	T5977	T5976	pobj	E15.5,by
R3636	T5978	T5971	prep	in,seen
R3637	T5979	T5980	amod	interphalangeal,joints
R3638	T5980	T5978	pobj	joints,in
R3639	T5981	T5980	cc	and,joints
R3640	T5982	T5983	amod	periarticular,regions
R3641	T5983	T5980	conj	regions,joints
R3642	T5984	T5985	punct	(,Figure
R3643	T5985	T5971	parataxis	Figure,seen
R3644	T5986	T5985	nummod	4D,Figure
R3645	T5987	T5985	punct	),Figure
R3646	T5988	T5968	punct	", ",seen
R3647	T5989	T5990	det	no,difference
R3648	T5990	T5968	nsubjpass	difference,seen
R3649	T5991	T5990	prep	in,difference
R3650	T5992	T5991	pobj	morphology,in
R3651	T5993	T5992	cc	or,morphology
R3652	T5994	T5992	conj	expression,morphology
R3653	T5995	T5992	prep	of,morphology
R3654	T5996	T5995	pobj	Col2a1,of
R3655	T5997	T5996	punct	", ",Col2a1
R3656	T5998	T5996	conj	Gdf5,Col2a1
R3657	T5999	T5998	punct	", ",Gdf5
R3658	T6000	T5998	cc	or,Gdf5
R3659	T6001	T5998	conj	Bmpr1b,Gdf5
R3660	T6002	T5968	auxpass	was,seen
R3661	T6003	T5968	prep	in,seen
R3662	T6004	T6005	det	the,regions
R3663	T6005	T6003	pobj	regions,in
R3664	T6006	T6005	amod	articular,regions
R3665	T6007	T6005	prep	of,regions
R3666	T6008	T6009	det	the,phalanges
R3667	T6009	T6007	pobj	phalanges,of
R3668	T6010	T5968	prep	at,seen
R3669	T6011	T6012	det	these,stages
R3670	T6012	T6010	pobj	stages,at
R3671	T6013	T6014	punct	(,data
R3672	T6014	T5968	meta	data,seen
R3673	T6015	T6014	amod	unpublished,data
R3674	T6016	T6014	punct	),data
R3675	T6017	T5968	punct	.,seen
R3676	T6019	T6020	prep	At,were
R3677	T6020	T6025	ccomp	were,were
R3678	T6021	T6019	pobj	birth,At
R3679	T6022	T6020	punct	", ",were
R3680	T6023	T6024	compound	digit,joints
R3681	T6024	T6020	nsubj	joints,were
R3682	T6026	T6020	advmod	generally,were
R3683	T6027	T6020	acomp	indistinguishable,were
R3684	T6028	T6027	prep	from,indistinguishable
R3685	T6029	T6028	pobj	those,from
R3686	T6030	T6029	prep	in,those
R3687	T6031	T6032	compound	control,animals
R3688	T6032	T6030	pobj	animals,in
R3689	T6033	T6025	punct	;,were
R3690	T6034	T6025	nsubj	chondrocytes,were
R3691	T6035	T6025	acomp	abundant,were
R3692	T6036	T6025	prep	in,were
R3693	T6037	T6038	amod	articular,regions
R3694	T6038	T6036	pobj	regions,in
R3695	T6039	T6025	cc	and,were
R3696	T6040	T6041	auxpass	were,surrounded
R3697	T6041	T6025	conj	surrounded,were
R3698	T6042	T6041	agent	by,surrounded
R3699	T6043	T6044	amod	typical,matrix
R3700	T6044	T6042	pobj	matrix,by
R3701	T6045	T6044	compound	cartilage,matrix
R3702	T6046	T6041	prep	with,surrounded
R3703	T6047	T6048	amod	normal,staining
R3704	T6048	T6046	pobj	staining,with
R3705	T6049	T6048	prep	by,staining
R3706	T6050	T6051	compound	Safranin,O
R3707	T6051	T6049	pobj	O,by
R3708	T6052	T6051	punct	", ",O
R3709	T6053	T6054	det	a,stain
R3710	T6054	T6051	appos	stain,O
R3711	T6055	T6054	amod	histological,stain
R3712	T6056	T6054	prep	for,stain
R3713	T6057	T6056	pobj	proteoglycans,for
R3714	T6058	T6059	punct	(,Figure
R3715	T6059	T6041	parataxis	Figure,surrounded
R3716	T6060	T6059	nummod	5,Figure
R3717	T6061	T6059	punct	),Figure
R3718	T6062	T6025	punct	.,were
R3719	T6064	T6065	prep	At,expressed
R3720	T6066	T6067	det	this,stage
R3721	T6067	T6064	pobj	stage,At
R3722	T6068	T6065	punct	", ",expressed
R3723	T6069	T6070	preconj	both,type
R3724	T6070	T6073	nmod	type,cells
R3725	T6071	T6070	amod	wild,type
R3726	T6072	T6070	punct	-,type
R3727	T6073	T6065	nsubj	cells,expressed
R3728	T6074	T6070	cc	and,type
R3729	T6075	T6070	conj	mutant,type
R3730	T6076	T6073	prep	in,cells
R3731	T6077	T6078	amod	articular,regions
R3732	T6078	T6076	pobj	regions,in
R3733	T6079	T6065	advmod	also,expressed
R3734	T6080	T6081	amod	high,levels
R3735	T6081	T6065	dobj	levels,expressed
R3736	T6082	T6081	prep	of,levels
R3737	T6083	T6082	pobj	Col2a1,of
R3738	T6084	T6083	cc	and,Col2a1
R3739	T6085	T6083	conj	Aggrecan,Col2a1
R3740	T6086	T6085	punct	(,Aggrecan
R3741	T6087	T6085	appos	Agg,Aggrecan
R3742	T6088	T6085	punct	),Aggrecan
R3743	T6089	T6083	punct	", ",Col2a1
R3744	T6090	T6091	det	the,genes
R3745	T6091	T6083	appos	genes,Col2a1
R3746	T6092	T6091	acl	encoding,genes
R3747	T6093	T6094	det	the,proteins
R3748	T6094	T6092	dobj	proteins,encoding
R3749	T6095	T6094	amod	major,proteins
R3750	T6096	T6094	amod	structural,proteins
R3751	T6097	T6094	prep	of,proteins
R3752	T6098	T6099	compound	cartilage,matrix
R3753	T6099	T6097	pobj	matrix,of
R3754	T6100	T6101	punct	(,Figure
R3755	T6101	T6065	parataxis	Figure,expressed
R3756	T6102	T6101	nummod	5B,Figure
R3757	T6103	T6101	cc	and,Figure
R3758	T6104	T6101	conj	5G,Figure
R3759	T6105	T6101	punct	),Figure
R3760	T6106	T6107	punct	(,data
R3761	T6107	T6065	meta	data,expressed
R3762	T6108	T6107	amod	unpublished,data
R3763	T6109	T6107	punct	),data
R3764	T6110	T6065	punct	.,expressed
R3765	T6112	T6113	det	No,alterations
R3766	T6113	T6114	nsubjpass	alterations,observed
R3767	T6115	T6113	prep	in,alterations
R3768	T6116	T6117	amod	cellular,apoptosis
R3769	T6117	T6115	pobj	apoptosis,in
R3770	T6118	T6117	cc	or,apoptosis
R3771	T6119	T6117	conj	proliferation,apoptosis
R3772	T6120	T6114	auxpass	were,observed
R3773	T6121	T6122	punct	(,data
R3774	T6122	T6114	meta	data,observed
R3775	T6123	T6122	amod	unpublished,data
R3776	T6124	T6122	punct	),data
R3777	T6125	T6114	punct	.,observed
R3778	T6127	T6128	aux	To,determine
R3779	T6128	T6129	advcl	determine,analyzed
R3780	T6130	T6131	mark	whether,specified
R3781	T6131	T6128	ccomp	specified,determine
R3782	T6132	T6133	amod	articular,cells
R3783	T6133	T6131	nsubjpass	cells,specified
R3784	T6134	T6131	auxpass	were,specified
R3785	T6135	T6131	advmod	properly,specified
R3786	T6136	T6131	prep	in,specified
R3787	T6137	T6136	pobj	mutants,in
R3788	T6138	T6129	punct	", ",analyzed
R3789	T6139	T6129	nsubj	we,analyzed
R3790	T6140	T6129	advmod	also,analyzed
R3791	T6141	T6129	dobj	expression,analyzed
R3792	T6142	T6141	prep	of,expression
R3793	T6143	T6142	pobj	Matrilin,of
R3794	T6144	T6143	punct	-,Matrilin
R3795	T6145	T6143	nummod	4,Matrilin
R3796	T6146	T6143	punct	(,Matrilin
R3797	T6147	T6143	appos	Mat4,Matrilin
R3798	T6148	T6143	punct	),Matrilin
R3799	T6149	T6143	punct	", ",Matrilin
R3800	T6150	T6151	det	a,gene
R3801	T6151	T6143	appos	gene,Matrilin
R3802	T6152	T6151	acl	expressed,gene
R3803	T6153	T6152	advmod	specifically,expressed
R3804	T6154	T6152	prep	in,expressed
R3805	T6155	T6156	det	the,regions
R3806	T6156	T6154	pobj	regions,in
R3807	T6157	T6156	amod	periarticular,regions
R3808	T6158	T6157	cc	and,periarticular
R3809	T6159	T6157	conj	perichondral,periarticular
R3810	T6160	T6156	prep	of,regions
R3811	T6161	T6162	amod	developing,joints
R3812	T6162	T6160	pobj	joints,of
R3813	T6163	T6164	punct	(,Klatt
R3814	T6164	T6129	meta	Klatt,analyzed
R3815	T6165	T6164	nmod	et,Klatt
R3816	T6166	T6164	nmod	al.,Klatt
R3817	T6167	T6164	nummod	2001,Klatt
R3818	T6168	T6164	punct	),Klatt
R3819	T6169	T6129	punct	.,analyzed
R3820	T6171	T6172	prep	In,was
R3821	T6173	T6174	preconj	both,control
R3822	T6174	T6175	nmod	control,animals
R3823	T6175	T6171	pobj	animals,In
R3824	T6176	T6174	cc	and,control
R3825	T6177	T6174	conj	mutant,control
R3826	T6178	T6172	punct	", ",was
R3827	T6179	T6172	nsubj	transcription,was
R3828	T6180	T6179	prep	of,transcription
R3829	T6181	T6180	pobj	Mat4,of
R3830	T6182	T6172	advmod	clearly,was
R3831	T6183	T6172	acomp	detectable,was
R3832	T6184	T6172	prep	in,was
R3833	T6185	T6186	det	the,layers
R3834	T6186	T6184	pobj	layers,in
R3835	T6187	T6188	amod	articular,cartilage
R3836	T6188	T6186	compound	cartilage,layers
R3837	T6189	T6186	prep	of,layers
R3838	T6190	T6191	amod	newborn,joints
R3839	T6191	T6189	pobj	joints,of
R3840	T6192	T6193	punct	(,5D
R3841	T6193	T6172	parataxis	5D,was
R3842	T6194	T6193	nmod	Figure,5D
R3843	T6195	T6193	cc	and,5D
R3844	T6196	T6193	conj	5I,5D
R3845	T6197	T6193	punct	),5D
R3846	T6198	T6172	punct	.,was
R3847	T6200	T6201	prep	In,indicated
R3848	T6202	T6203	det	all,experiments
R3849	T6203	T6200	pobj	experiments,In
R3850	T6204	T6201	punct	", ",indicated
R3851	T6205	T6201	nsubj	expression,indicated
R3852	T6206	T6205	prep	of,expression
R3853	T6207	T6206	pobj	LACZ,of
R3854	T6208	T6205	prep	throughout,expression
R3855	T6209	T6210	amod	articular,regions
R3856	T6210	T6208	pobj	regions,throughout
R3857	T6211	T6212	mark	that,occurred
R3858	T6212	T6201	ccomp	occurred,indicated
R3859	T6213	T6214	npadvmod	Cre,mediated
R3860	T6214	T6216	amod	mediated,recombination
R3861	T6215	T6214	punct	-,mediated
R3862	T6216	T6212	nsubj	recombination,occurred
R3863	T6217	T6212	aux	had,occurred
R3864	T6218	T6212	prep	throughout,occurred
R3865	T6219	T6220	det	the,regions
R3866	T6220	T6218	pobj	regions,throughout
R3867	T6221	T6220	amod	articular,regions
R3868	T6222	T6223	punct	(,Figure
R3869	T6223	T6201	parataxis	Figure,indicated
R3870	T6224	T6223	nummod	5C,Figure
R3871	T6225	T6223	punct	", ",Figure
R3872	T6226	T6223	nummod	5H,Figure
R3873	T6227	T6223	punct	", ",Figure
R3874	T6228	T6223	nummod	5E,Figure
R3875	T6229	T6223	punct	", ",Figure
R3876	T6230	T6223	cc	and,Figure
R3877	T6231	T6223	conj	5J,Figure
R3878	T6232	T6223	punct	),Figure
R3879	T6233	T6201	punct	.,indicated
R3880	T6235	T6236	det	The,appearance
R3881	T6236	T6239	nsubj	appearance,suggest
R3882	T6237	T6236	amod	normal,appearance
R3883	T6238	T6236	amod	histological,appearance
R3884	T6240	T6236	punct	", ",appearance
R3885	T6241	T6242	amod	staining,properties
R3886	T6242	T6236	conj	properties,appearance
R3887	T6243	T6242	punct	", ",properties
R3888	T6244	T6242	cc	and,properties
R3889	T6245	T6246	compound	marker,gene
R3890	T6246	T6247	compound	gene,patterns
R3891	T6247	T6242	conj	patterns,properties
R3892	T6248	T6247	compound	expression,patterns
R3893	T6249	T6250	mark	that,required
R3894	T6250	T6239	ccomp	required,suggest
R3895	T6251	T6250	nsubjpass	Bmpr1a,required
R3896	T6252	T6250	auxpass	is,required
R3897	T6253	T6250	neg	not,required
R3898	T6254	T6250	prep	for,required
R3899	T6255	T6256	det	the,formation
R3900	T6256	T6254	pobj	formation,for
R3901	T6257	T6256	amod	initial,formation
R3902	T6258	T6256	cc	or,formation
R3903	T6259	T6256	conj	specification,formation
R3904	T6260	T6256	prep	of,formation
R3905	T6261	T6262	amod	articular,cartilage
R3906	T6262	T6260	pobj	cartilage,of
R3907	T6263	T6239	punct	.,suggest
R3908	T6265	T6266	prep	By,began
R3909	T6267	T6268	nummod	1,wk
R3910	T6268	T6265	pobj	wk,By
R3911	T6269	T6268	prep	after,wk
R3912	T6270	T6269	pobj	birth,after
R3913	T6271	T6266	punct	", ",began
R3914	T6272	T6273	amod	obvious,differences
R3915	T6273	T6266	nsubj	differences,began
R3916	T6274	T6275	aux	to,detected
R3917	T6275	T6266	xcomp	detected,began
R3918	T6276	T6275	auxpass	be,detected
R3919	T6277	T6275	prep	in,detected
R3920	T6278	T6279	det	the,regions
R3921	T6279	T6277	pobj	regions,in
R3922	T6280	T6279	amod	articular,regions
R3923	T6281	T6279	prep	of,regions
R3924	T6282	T6283	compound	mutant,animals
R3925	T6283	T6281	pobj	animals,of
R3926	T6284	T6266	punct	.,began
R3927	T6286	T6287	det	The,expression
R3928	T6287	T6288	nsubjpass	expression,reduced
R3929	T6289	T6287	prep	of,expression
R3930	T6290	T6289	pobj	Col2a1,of
R3931	T6291	T6288	auxpass	was,reduced
R3932	T6292	T6288	prep	throughout,reduced
R3933	T6293	T6294	det	the,surfaces
R3934	T6294	T6292	pobj	surfaces,throughout
R3935	T6295	T6294	amod	articular,surfaces
R3936	T6296	T6294	prep	of,surfaces
R3937	T6297	T6298	det	the,carpals
R3938	T6298	T6296	pobj	carpals,of
R3939	T6299	T6298	punct	", ",carpals
R3940	T6300	T6298	conj	metacarpals,carpals
R3941	T6301	T6300	punct	", ",metacarpals
R3942	T6302	T6300	cc	and,metacarpals
R3943	T6303	T6300	conj	phalanges,metacarpals
R3944	T6304	T6298	prep	of,carpals
R3945	T6305	T6306	det	the,forefeet
R3946	T6306	T6304	pobj	forefeet,of
R3947	T6307	T6308	punct	(,data
R3948	T6308	T6288	meta	data,reduced
R3949	T6309	T6308	amod	unpublished,data
R3950	T6310	T6308	punct	),data
R3951	T6311	T6288	punct	.,reduced
R3952	T6313	T6314	advmod	Less,severe
R3953	T6314	T6315	amod	severe,reductions
R3954	T6315	T6316	nsubjpass	reductions,seen
R3955	T6317	T6316	auxpass	were,seen
R3956	T6318	T6316	advmod	also,seen
R3957	T6319	T6316	prep	in,seen
R3958	T6320	T6321	amod	articular,cells
R3959	T6321	T6319	pobj	cells,in
R3960	T6322	T6321	prep	of,cells
R3961	T6323	T6322	pobj	tarsals,of
R3962	T6324	T6323	cc	and,tarsals
R3963	T6325	T6323	conj	metatarsals,tarsals
R3964	T6326	T6323	prep	in,tarsals
R3965	T6327	T6328	det	the,hindfeet
R3966	T6328	T6326	pobj	hindfeet,in
R3967	T6329	T6330	punct	(,data
R3968	T6330	T6316	meta	data,seen
R3969	T6331	T6330	amod	unpublished,data
R3970	T6332	T6330	punct	),data
R3971	T6333	T6316	punct	.,seen
R3972	T6335	T6336	prep	By,reduced
R3973	T6337	T6338	nummod	2,wk
R3974	T6338	T6335	pobj	wk,By
R3975	T6339	T6338	prep	of,wk
R3976	T6340	T6339	pobj	age,of
R3977	T6341	T6336	punct	", ",reduced
R3978	T6342	T6343	compound	Col2a1,expression
R3979	T6343	T6336	nsubjpass	expression,reduced
R3980	T6344	T6336	auxpass	was,reduced
R3981	T6345	T6336	prep	in,reduced
R3982	T6346	T6347	amod	most,cells
R3983	T6347	T6345	pobj	cells,in
R3984	T6348	T6347	prep	of,cells
R3985	T6349	T6350	det	the,region
R3986	T6350	T6348	pobj	region,of
R3987	T6351	T6350	amod	articular,region
R3988	T6352	T6353	punct	(,Figure
R3989	T6353	T6336	parataxis	Figure,reduced
R3990	T6354	T6353	nummod	5L,Figure
R3991	T6355	T6353	cc	and,Figure
R3992	T6356	T6353	conj	5Q,Figure
R3993	T6357	T6353	punct	),Figure
R3994	T6358	T6336	punct	", ",reduced
R3995	T6359	T6336	advcl	accompanied,reduced
R3996	T6360	T6359	agent	by,accompanied
R3997	T6361	T6362	advmod	markedly,reduced
R3998	T6362	T6363	amod	reduced,staining
R3999	T6363	T6360	pobj	staining,by
R4000	T6364	T6365	compound	Safranin,O
R4001	T6365	T6363	compound	O,staining
R4002	T6366	T6367	punct	(,Figure
R4003	T6367	T6363	parataxis	Figure,staining
R4004	T6368	T6367	nummod	5K,Figure
R4005	T6369	T6367	cc	and,Figure
R4006	T6370	T6367	conj	5P,Figure
R4007	T6371	T6367	punct	),Figure
R4008	T6372	T6363	punct	", ",staining
R4009	T6373	T6363	cc	and,staining
R4010	T6374	T6375	amod	decreased,expression
R4011	T6375	T6363	conj	expression,staining
R4012	T6376	T6375	prep	of,expression
R4013	T6377	T6376	pobj	Agg,of
R4014	T6378	T6377	cc	and,Agg
R4015	T6379	T6380	nummod	two,genes
R4016	T6380	T6377	conj	genes,Agg
R4017	T6381	T6382	advmod	normally,expressed
R4018	T6382	T6380	acl	expressed,genes
R4019	T6383	T6382	prep	in,expressed
R4020	T6384	T6385	advmod	more,mature
R4021	T6385	T6386	amod	mature,cells
R4022	T6386	T6383	pobj	cells,in
R4023	T6387	T6388	amod	articular,cartilage
R4024	T6388	T6386	compound	cartilage,cells
R4025	T6389	T6380	punct	", ",genes
R4026	T6390	T6380	appos	Collagen,genes
R4027	T6391	T6390	nummod	3,Collagen
R4028	T6392	T6390	punct	(,Collagen
R4029	T6393	T6390	appos	Col3a1,Collagen
R4030	T6394	T6390	punct	),Collagen
R4031	T6395	T6390	cc	and,Collagen
R4032	T6396	T6390	conj	Collagen,Collagen
R4033	T6397	T6396	nummod	10,Collagen
R4034	T6398	T6396	punct	(,Collagen
R4035	T6399	T6396	appos	Col10a1,Collagen
R4036	T6400	T6396	punct	),Collagen
R4037	T6401	T6402	punct	(,Figure
R4038	T6402	T6336	parataxis	Figure,reduced
R4039	T6403	T6402	nummod	5M,Figure
R4040	T6404	T6402	cc	and,Figure
R4041	T6405	T6402	conj	5R,Figure
R4042	T6406	T6402	punct	),Figure
R4043	T6407	T6408	punct	(,data
R4044	T6408	T6336	meta	data,reduced
R4045	T6409	T6408	amod	unpublished,data
R4046	T6410	T6408	punct	),data
R4047	T6411	T6412	punct	(,Eyre
R4048	T6412	T6336	meta	Eyre,reduced
R4049	T6413	T6412	nummod	2002,Eyre
R4050	T6414	T6412	punct	),Eyre
R4051	T6415	T6336	punct	.,reduced
R4052	T6417	T6418	nsubjpass	Inhibition,reported
R4053	T6419	T6417	prep	of,Inhibition
R4054	T6420	T6421	compound	BMP,signaling
R4055	T6421	T6419	pobj	signaling,of
R4056	T6422	T6417	prep	in,Inhibition
R4057	T6423	T6424	amod	cultured,chondrocytes
R4058	T6424	T6422	pobj	chondrocytes,in
R4059	T6425	T6418	aux	has,reported
R4060	T6426	T6418	advmod	previously,reported
R4061	T6427	T6418	auxpass	been,reported
R4062	T6428	T6429	aux	to,induce
R4063	T6429	T6418	xcomp	induce,reported
R4064	T6430	T6431	nmod	Collagen,expression
R4065	T6431	T6429	dobj	expression,induce
R4066	T6432	T6430	nummod	1,Collagen
R4067	T6433	T6430	punct	(,Collagen
R4068	T6434	T6430	appos	Col1a1,Collagen
R4069	T6435	T6430	punct	),Collagen
R4070	T6436	T6429	punct	", ",induce
R4071	T6437	T6429	conj	increase,induce
R4072	T6438	T6437	dobj	proliferation,increase
R4073	T6439	T6437	punct	", ",increase
R4074	T6440	T6437	cc	and,increase
R4075	T6441	T6437	conj	result,increase
R4076	T6442	T6441	prep	in,result
R4077	T6443	T6442	pobj	cells,in
R4078	T6444	T6443	prep	with,cells
R4079	T6445	T6446	amod	flattened,morphology
R4080	T6446	T6444	pobj	morphology,with
R4081	T6447	T6446	punct	", ",morphology
R4082	T6448	T6449	npadvmod	fibroblast,like
R4083	T6449	T6446	amod	like,morphology
R4084	T6450	T6449	punct	-,like
R4085	T6451	T6452	punct	(,Enomoto
R4086	T6452	T6418	meta	Enomoto,reported
R4087	T6453	T6452	punct	-,Enomoto
R4088	T6454	T6452	nmod	Iwamoto,Enomoto
R4089	T6455	T6452	nmod	et,Enomoto
R4090	T6456	T6452	nmod	al.,Enomoto
R4091	T6457	T6452	nummod	1998,Enomoto
R4092	T6458	T6452	punct	),Enomoto
R4093	T6459	T6418	punct	.,reported
R4094	T6461	T6462	advmod	However,saw
R4095	T6463	T6462	punct	", ",saw
R4096	T6464	T6462	nsubj	we,saw
R4097	T6465	T6466	det	no,increase
R4098	T6466	T6462	dobj	increase,saw
R4099	T6467	T6466	prep	in,increase
R4100	T6468	T6469	det	the,expression
R4101	T6469	T6467	pobj	expression,in
R4102	T6470	T6469	prep	of,expression
R4103	T6471	T6470	pobj	Col1a1,of
R4104	T6472	T6466	prep	in,increase
R4105	T6473	T6474	nmod	mutant,cartilage
R4106	T6474	T6472	pobj	cartilage,in
R4107	T6475	T6474	amod	articular,cartilage
R4108	T6476	T6462	punct	", ",saw
R4109	T6477	T6462	cc	and,saw
R4110	T6478	T6479	det	no,proliferation
R4111	T6479	T6480	nsubjpass	proliferation,detected
R4112	T6480	T6462	conj	detected,saw
R4113	T6481	T6480	auxpass	was,detected
R4114	T6482	T6480	prep	in,detected
R4115	T6483	T6484	amod	articular,cells
R4116	T6484	T6482	pobj	cells,in
R4117	T6485	T6484	prep	of,cells
R4118	T6486	T6487	preconj	either,mutant
R4119	T6487	T6488	amod	mutant,animals
R4120	T6488	T6485	pobj	animals,of
R4121	T6489	T6487	cc	or,mutant
R4122	T6490	T6487	conj	control,mutant
R4123	T6491	T6492	punct	(,data
R4124	T6492	T6480	meta	data,detected
R4125	T6493	T6492	amod	unpublished,data
R4126	T6494	T6492	punct	),data
R4127	T6495	T6480	punct	.,detected
R4128	T6497	T6498	mark	While,detected
R4129	T6498	T6504	advcl	detected,observed
R4130	T6499	T6500	amod	recombined,expression
R4131	T6500	T6498	nsubjpass	expression,detected
R4132	T6501	T6502	compound	LACZ,marker
R4133	T6502	T6500	compound	marker,expression
R4134	T6503	T6498	auxpass	was,detected
R4135	T6505	T6498	prep	in,detected
R4136	T6506	T6507	amod	most,cells
R4137	T6507	T6505	pobj	cells,in
R4138	T6508	T6509	amod	articular,cartilage
R4139	T6509	T6507	compound	cartilage,cells
R4140	T6510	T6504	punct	", ",observed
R4141	T6511	T6504	nsubjpass	it,observed
R4142	T6512	T6504	auxpass	was,observed
R4143	T6513	T6504	advmod	also,observed
R4144	T6514	T6504	prep	in,observed
R4145	T6515	T6516	amod	scattered,chondrocytes
R4146	T6516	T6514	pobj	chondrocytes,in
R4147	T6517	T6516	amod	subarticular,chondrocytes
R4148	T6518	T6516	punct	", ",chondrocytes
R4149	T6519	T6520	compound	growth,plate
R4150	T6520	T6521	compound	plate,chondrocytes
R4151	T6521	T6516	conj	chondrocytes,chondrocytes
R4152	T6522	T6521	punct	", ",chondrocytes
R4153	T6523	T6521	cc	and,chondrocytes
R4154	T6524	T6521	conj	osteoblasts,chondrocytes
R4155	T6525	T6526	punct	(,Figure
R4156	T6526	T6504	parataxis	Figure,observed
R4157	T6527	T6526	nummod	5O,Figure
R4158	T6528	T6526	cc	and,Figure
R4159	T6529	T6526	conj	5T,Figure
R4160	T6530	T6526	punct	),Figure
R4161	T6531	T6532	punct	(,data
R4162	T6532	T6504	meta	data,observed
R4163	T6533	T6532	amod	unpublished,data
R4164	T6534	T6532	punct	),data
R4165	T6535	T6504	punct	.,observed
R4166	T6537	T6538	mark	Although,implies
R4167	T6538	T6540	advcl	implies,confined
R4168	T6539	T6538	nsubj	this,implies
R4169	T6541	T6542	mark	that,was
R4170	T6542	T6538	ccomp	was,implies
R4171	T6543	T6544	compound	BMP,signaling
R4172	T6544	T6542	nsubj	signaling,was
R4173	T6545	T6542	acomp	defective,was
R4174	T6546	T6542	prep	in,was
R4175	T6547	T6548	amod	multiple,types
R4176	T6548	T6546	pobj	types,in
R4177	T6549	T6548	compound	cell,types
R4178	T6550	T6540	punct	", ",confined
R4179	T6551	T6552	det	the,defects
R4180	T6552	T6540	nsubjpass	defects,confined
R4181	T6553	T6552	amod	observed,defects
R4182	T6554	T6540	auxpass	were,confined
R4183	T6555	T6540	prep	to,confined
R4184	T6556	T6557	det	the,cartilage
R4185	T6557	T6555	pobj	cartilage,to
R4186	T6558	T6557	amod	articular,cartilage
R4187	T6559	T6540	punct	.,confined
R4188	T6561	T6562	prep	For,appeared
R4189	T6563	T6561	pobj	example,For
R4190	T6564	T6562	punct	", ",appeared
R4191	T6565	T6566	nmod	Osteocalcin,expression
R4192	T6566	T6562	nsubj	expression,appeared
R4193	T6567	T6565	cc	and,Osteocalcin
R4194	T6568	T6565	conj	Col1a1,Osteocalcin
R4195	T6569	T6562	oprd	normal,appeared
R4196	T6570	T6562	prep	in,appeared
R4197	T6571	T6570	pobj	osteoblasts,in
R4198	T6572	T6573	punct	(,data
R4199	T6573	T6562	meta	data,appeared
R4200	T6574	T6573	amod	unpublished,data
R4201	T6575	T6573	punct	),data
R4202	T6576	T6562	punct	.,appeared
R4203	T6578	T6579	advmod	Together,suggest
R4204	T6580	T6579	punct	", ",suggest
R4205	T6581	T6582	det	these,data
R4206	T6582	T6579	nsubj	data,suggest
R4207	T6583	T6584	mark	that,required
R4208	T6584	T6579	ccomp	required,suggest
R4209	T6585	T6586	compound	BMPR1A,activity
R4210	T6586	T6584	nsubjpass	activity,required
R4211	T6587	T6584	auxpass	is,required
R4212	T6588	T6584	prep	in,required
R4213	T6589	T6590	amod	postnatal,cartilage
R4214	T6590	T6588	pobj	cartilage,in
R4215	T6591	T6592	npadvmod	joint,articular
R4216	T6592	T6590	amod	articular,cartilage
R4217	T6593	T6594	aux	to,maintain
R4218	T6594	T6584	advcl	maintain,required
R4219	T6595	T6594	dobj	expression,maintain
R4220	T6596	T6595	prep	of,expression
R4221	T6597	T6598	amod	many,genes
R4222	T6598	T6596	pobj	genes,of
R4223	T6599	T6598	acl	encoding,genes
R4224	T6600	T6601	amod	structural,components
R4225	T6601	T6599	dobj	components,encoding
R4226	T6602	T6601	prep	of,components
R4227	T6603	T6604	compound	cartilage,matrix
R4228	T6604	T6602	pobj	matrix,of
R4229	T6605	T6579	punct	.,suggest
R4230	T6607	T6608	amod	Previous,studies
R4231	T6608	T6609	nsubj	studies,shown
R4232	T6610	T6609	aux	have,shown
R4233	T6611	T6612	mark	that,required
R4234	T6612	T6609	ccomp	required,shown
R4235	T6613	T6612	nsubjpass	Sox9,required
R4236	T6614	T6612	auxpass	is,required
R4237	T6615	T6612	prep	for,required
R4238	T6616	T6617	amod	normal,differentiation
R4239	T6617	T6615	pobj	differentiation,for
R4240	T6618	T6617	compound	cartilage,differentiation
R4241	T6619	T6615	punct	", ",for
R4242	T6620	T6615	prep	for,for
R4243	T6621	T6620	pobj	expression,for
R4244	T6622	T6621	prep	of,expression
R4245	T6623	T6624	nmod	cartilage,matrix
R4246	T6624	T6626	nmod	matrix,genes
R4247	T6625	T6624	amod	extracellular,matrix
R4248	T6626	T6622	pobj	genes,of
R4249	T6627	T6624	punct	(,matrix
R4250	T6628	T6624	appos	ECM,matrix
R4251	T6629	T6624	punct	),matrix
R4252	T6630	T6626	prep	including,genes
R4253	T6631	T6630	pobj	Agg,including
R4254	T6632	T6612	punct	", ",required
R4255	T6633	T6612	cc	and,required
R4256	T6634	T6612	conj	is,required
R4257	T6635	T6636	det	a,regulator
R4258	T6636	T6634	attr	regulator,is
R4259	T6637	T6636	amod	direct,regulator
R4260	T6638	T6636	amod	transcriptional,regulator
R4261	T6639	T6636	prep	of,regulator
R4262	T6640	T6641	det	the,Col2a1
R4263	T6641	T6639	pobj	Col2a1,of
R4264	T6642	T6641	amod	key,Col2a1
R4265	T6643	T6644	compound	cartilage,matrix
R4266	T6644	T6641	compound	matrix,Col2a1
R4267	T6645	T6641	compound	gene,Col2a1
R4268	T6646	T6647	punct	(,Bell
R4269	T6647	T6634	meta	Bell,is
R4270	T6648	T6647	nmod	et,Bell
R4271	T6649	T6647	nmod	al.,Bell
R4272	T6650	T6647	nummod	1997,Bell
R4273	T6651	T6647	punct	;,Bell
R4274	T6652	T6647	nmod	Lefebvre,Bell
R4275	T6653	T6647	nmod	et,Bell
R4276	T6654	T6647	nmod	al.,Bell
R4277	T6655	T6647	nummod	1997,Bell
R4278	T6656	T6647	punct	;,Bell
R4279	T6657	T6647	nmod	Bi,Bell
R4280	T6658	T6647	nmod	et,Bell
R4281	T6659	T6647	nmod	al.,Bell
R4282	T6660	T6647	nummod	1999,Bell
R4283	T6661	T6647	punct	;,Bell
R4284	T6662	T6647	nmod	Sekiya,Bell
R4285	T6663	T6647	nmod	et,Bell
R4286	T6664	T6647	nmod	al.,Bell
R4287	T6665	T6647	nummod	2000,Bell
R4288	T6666	T6647	punct	),Bell
R4289	T6667	T6609	punct	.,shown
R4290	T6669	T6670	advmod	Notably,was
R4291	T6671	T6670	punct	", ",was
R4292	T6672	T6670	prep	despite,was
R4293	T6673	T6674	amod	reduced,expression
R4294	T6674	T6672	pobj	expression,despite
R4295	T6675	T6674	prep	of,expression
R4296	T6676	T6677	amod	many,genes
R4297	T6677	T6675	pobj	genes,of
R4298	T6678	T6679	compound	cartilage,matrix
R4299	T6679	T6677	compound	matrix,genes
R4300	T6680	T6677	compound	marker,genes
R4301	T6681	T6674	prep	in,expression
R4302	T6682	T6683	npadvmod	Bmpr1a,mutant
R4303	T6683	T6684	amod	mutant,mice
R4304	T6684	T6681	pobj	mice,in
R4305	T6685	T6670	punct	", ",was
R4306	T6686	T6687	det	the,protein
R4307	T6687	T6670	nsubj	protein,was
R4308	T6688	T6687	compound	SOX9,protein
R4309	T6689	T6670	acomp	present,was
R4310	T6690	T6670	prep	at,was
R4311	T6691	T6692	amod	normal,levels
R4312	T6692	T6690	pobj	levels,at
R4313	T6693	T6670	prep	in,was
R4314	T6694	T6695	amod	articular,regions
R4315	T6695	T6693	pobj	regions,in
R4316	T6696	T6670	prep	at,was
R4317	T6697	T6698	det	all,stages
R4318	T6698	T6696	pobj	stages,at
R4319	T6699	T6698	acl	examined,stages
R4320	T6700	T6698	punct	", ",stages
R4321	T6701	T6698	prep	including,stages
R4322	T6702	T6703	amod	newborn,mice
R4323	T6703	T6701	pobj	mice,including
R4324	T6704	T6702	punct	", ",newborn
R4325	T6705	T6706	nummod	2,wk
R4326	T6706	T6708	npadvmod	wk,old
R4327	T6707	T6706	punct	-,wk
R4328	T6708	T6702	conj	old,newborn
R4329	T6709	T6708	punct	-,old
R4330	T6710	T6708	punct	", ",old
R4331	T6711	T6712	nummod	7,wk
R4332	T6712	T6714	npadvmod	wk,old
R4333	T6713	T6712	punct	-,wk
R4334	T6714	T6708	conj	old,old
R4335	T6715	T6714	punct	-,old
R4336	T6716	T6714	punct	", ",old
R4337	T6717	T6714	cc	and,old
R4338	T6718	T6719	nummod	9,mo
R4339	T6719	T6721	npadvmod	mo,old
R4340	T6720	T6719	punct	-,mo
R4341	T6721	T6714	conj	old,old
R4342	T6722	T6721	punct	-,old
R4343	T6723	T6724	punct	(,Figure
R4344	T6724	T6670	parataxis	Figure,was
R4345	T6725	T6724	nummod	5N,Figure
R4346	T6726	T6724	cc	and,Figure
R4347	T6727	T6724	conj	5S,Figure
R4348	T6728	T6724	punct	),Figure
R4349	T6729	T6730	punct	(,data
R4350	T6730	T6670	meta	data,was
R4351	T6731	T6730	amod	unpublished,data
R4352	T6732	T6730	punct	),data
R4353	T6733	T6670	punct	.,was
R4354	T6897	T6898	amod	Synovial,Hypertrophy
R4355	T6899	T6898	punct	", ",Hypertrophy
R4356	T6900	T6901	compound	Cartilage,Erosion
R4357	T6901	T6898	conj	Erosion,Hypertrophy
R4358	T6902	T6901	punct	", ",Erosion
R4359	T6903	T6901	cc	and,Erosion
R4360	T6904	T6905	amod	Accelerated,Maturation
R4361	T6905	T6901	conj	Maturation,Erosion
R4362	T6906	T6905	compound	Cartilage,Maturation
R4363	T6908	T6909	amod	Conditional,loss
R4364	T6909	T6910	nsubj	loss,led
R4365	T6911	T6909	prep	of,loss
R4366	T6912	T6911	pobj	Bmpr1a,of
R4367	T6913	T6910	prep	to,led
R4368	T6914	T6915	amod	marked,hypertrophy
R4369	T6915	T6913	pobj	hypertrophy,to
R4370	T6916	T6915	prep	of,hypertrophy
R4371	T6917	T6918	det	the,membrane
R4372	T6918	T6916	pobj	membrane,of
R4373	T6919	T6918	amod	synovial,membrane
R4374	T6920	T6915	prep	in,hypertrophy
R4375	T6921	T6922	det	the,capsule
R4376	T6922	T6920	pobj	capsule,in
R4377	T6923	T6922	compound	joint,capsule
R4378	T6924	T6922	prep	of,capsule
R4379	T6925	T6926	det	some,joints
R4380	T6926	T6924	pobj	joints,of
R4381	T6927	T6915	punct	", ",hypertrophy
R4382	T6928	T6929	advmod	particularly,in
R4383	T6929	T6915	prep	in,hypertrophy
R4384	T6930	T6931	det	the,region
R4385	T6931	T6929	pobj	region,in
R4386	T6932	T6931	compound	ankle,region
R4387	T6933	T6910	punct	.,led
R4388	T6935	T6936	prep	In,grew
R4389	T6937	T6938	det	the,joints
R4390	T6938	T6935	pobj	joints,In
R4391	T6939	T6940	advmod	most,severely
R4392	T6940	T6941	advmod	severely,affected
R4393	T6941	T6938	amod	affected,joints
R4394	T6942	T6936	punct	", ",grew
R4395	T6943	T6944	det	the,membrane
R4396	T6944	T6936	nsubj	membrane,grew
R4397	T6945	T6944	amod	expanded,membrane
R4398	T6946	T6944	amod	synovial,membrane
R4399	T6947	T6936	prep	into,grew
R4400	T6948	T6949	det	the,space
R4401	T6949	T6947	pobj	space,into
R4402	T6950	T6949	compound	joint,space
R4403	T6951	T6936	cc	and,grew
R4404	T6952	T6953	auxpass	was,associated
R4405	T6953	T6936	conj	associated,grew
R4406	T6954	T6953	prep	with,associated
R4407	T6955	T6956	amod	obvious,loss
R4408	T6956	T6954	pobj	loss,with
R4409	T6957	T6956	cc	or,loss
R4410	T6958	T6956	conj	erosion,loss
R4411	T6959	T6956	prep	of,loss
R4412	T6960	T6961	det	the,cartilage
R4413	T6961	T6959	pobj	cartilage,of
R4414	T6962	T6961	amod	articular,cartilage
R4415	T6963	T6964	punct	(,arrows
R4416	T6964	T6953	parataxis	arrows,associated
R4417	T6965	T6964	dep	Figure,arrows
R4418	T6966	T6965	nummod	6A,Figure
R4419	T6967	T6965	cc	and,Figure
R4420	T6968	T6965	conj	6B,Figure
R4421	T6969	T6964	punct	", ",arrows
R4422	T6970	T6964	dep	asterisks,arrows
R4423	T6971	T6964	punct	", ",arrows
R4424	T6972	T6964	punct	),arrows
R4425	T6973	T6936	punct	.,grew
R4426	T6975	T6976	amod	Accelerated,maturation
R4427	T6976	T6978	nsubjpass	maturation,seen
R4428	T6977	T6976	compound	cartilage,maturation
R4429	T6979	T6976	cc	and,maturation
R4430	T6980	T6981	amod	increased,expression
R4431	T6981	T6976	conj	expression,maturation
R4432	T6982	T6981	prep	of,expression
R4433	T6983	T6982	pobj	Col10a1,of
R4434	T6984	T6978	auxpass	was,seen
R4435	T6985	T6978	advmod	frequently,seen
R4436	T6986	T6978	prep	in,seen
R4437	T6987	T6988	det	the,chondrocytes
R4438	T6988	T6986	pobj	chondrocytes,in
R4439	T6989	T6988	acl	underlying,chondrocytes
R4440	T6990	T6991	det	the,erosions
R4441	T6991	T6989	dobj	erosions,underlying
R4442	T6992	T6991	amod	articular,erosions
R4443	T6993	T6994	punct	(,brackets
R4444	T6994	T6978	parataxis	brackets,seen
R4445	T6995	T6994	dep	Figure,brackets
R4446	T6996	T6995	nummod	6C,Figure
R4447	T6997	T6995	cc	and,Figure
R4448	T6998	T6995	conj	6D,Figure
R4449	T6999	T6994	punct	", ",brackets
R4450	T7000	T6994	punct	),brackets
R4451	T7001	T7002	punct	(,data
R4452	T7002	T6978	meta	data,seen
R4453	T7003	T7002	amod	unpublished,data
R4454	T7004	T7002	punct	),data
R4455	T7005	T6978	punct	.,seen
R4456	T7007	T7008	advmod	Interestingly,correspond
R4457	T7009	T7008	punct	", ",correspond
R4458	T7010	T7011	det	the,regions
R4459	T7011	T7008	nsubj	regions,correspond
R4460	T7012	T7011	prep	of,regions
R4461	T7013	T7014	amod	increased,expression
R4462	T7014	T7012	pobj	expression,of
R4463	T7015	T7014	compound	Col10a1,expression
R4464	T7016	T7008	aux	did,correspond
R4465	T7017	T7008	neg	not,correspond
R4466	T7018	T7008	prep	to,correspond
R4467	T7019	T7020	det	the,regions
R4468	T7020	T7018	pobj	regions,to
R4469	T7021	T7022	dep	that,undergone
R4470	T7022	T7020	relcl	undergone,regions
R4471	T7023	T7022	aux	had,undergone
R4472	T7024	T7025	npadvmod	Cre,mediated
R4473	T7025	T7027	amod	mediated,recombination
R4474	T7026	T7025	punct	-,mediated
R4475	T7027	T7022	dobj	recombination,undergone
R4476	T7028	T7008	punct	.,correspond
R4477	T7030	T7031	advmod	Instead,seen
R4478	T7032	T7031	punct	", ",seen
R4479	T7033	T7034	amod	increased,expression
R4480	T7034	T7031	nsubjpass	expression,seen
R4481	T7035	T7034	prep	of,expression
R4482	T7036	T7035	pobj	Col10a1,of
R4483	T7037	T7031	auxpass	was,seen
R4484	T7038	T7031	prep	in,seen
R4485	T7039	T7040	det	a,zone
R4486	T7040	T7038	pobj	zone,in
R4487	T7041	T7040	prep	of,zone
R4488	T7042	T7043	advmod	largely,cells
R4489	T7043	T7041	pobj	cells,of
R4490	T7044	T7045	npadvmod	LACZ,negative
R4491	T7045	T7043	amod	negative,cells
R4492	T7046	T7045	punct	-,negative
R4493	T7047	T7040	acl	stretching,zone
R4494	T7048	T7047	prep	from,stretching
R4495	T7049	T7050	det	the,cartilage
R4496	T7050	T7048	pobj	cartilage,from
R4497	T7051	T7050	amod	adjacent,cartilage
R4498	T7052	T7051	prep	to,adjacent
R4499	T7053	T7054	det	the,front
R4500	T7054	T7052	pobj	front,to
R4501	T7055	T7054	compound	ossification,front
R4502	T7056	T7050	punct	(,cartilage
R4503	T7057	T7058	advmod	where,expressed
R4504	T7058	T7050	relcl	expressed,cartilage
R4505	T7059	T7058	nsubjpass	Col10a1,expressed
R4506	T7060	T7058	auxpass	is,expressed
R4507	T7061	T7058	advmod	normally,expressed
R4508	T7062	T7058	prep	in,expressed
R4509	T7063	T7064	amod	maturing,cells
R4510	T7064	T7062	pobj	cells,in
R4511	T7065	T7064	compound	cartilage,cells
R4512	T7066	T7050	punct	),cartilage
R4513	T7067	T7047	punct	", ",stretching
R4514	T7068	T7047	prep	toward,stretching
R4515	T7069	T7070	det	the,regions
R4516	T7070	T7068	pobj	regions,toward
R4517	T7071	T7072	advmod	where,was
R4518	T7072	T7070	relcl	was,regions
R4519	T7073	T7074	nmod	surface,cartilage
R4520	T7074	T7072	nsubj	cartilage,was
R4521	T7075	T7074	amod	articular,cartilage
R4522	T7076	T7077	advmod	severely,eroded
R4523	T7077	T7072	acomp	eroded,was
R4524	T7078	T7077	cc	or,eroded
R4525	T7079	T7077	conj	missing,eroded
R4526	T7080	T7081	punct	(,arrowheads
R4527	T7081	T7072	parataxis	arrowheads,was
R4528	T7082	T7081	dep	Figure,arrowheads
R4529	T7083	T7082	nummod	6A,Figure
R4530	T7084	T7082	cc	and,Figure
R4531	T7085	T7082	conj	6B,Figure
R4532	T7086	T7081	punct	", ",arrowheads
R4533	T7087	T7081	punct	),arrowheads
R4534	T7088	T7031	punct	.,seen
R4535	T7090	T7091	amod	Previous,studies
R4536	T7091	T7092	nsubj	studies,suggest
R4537	T7093	T7094	mark	that,inhibit
R4538	T7094	T7092	ccomp	inhibit,suggest
R4539	T7095	T7096	compound	parathyroid,hormone
R4540	T7096	T7097	npadvmod	hormone,related
R4541	T7097	T7099	amod	related,protein
R4542	T7098	T7097	punct	-,related
R4543	T7099	T7094	nsubj	protein,inhibit
R4544	T7100	T7099	punct	", ",protein
R4545	T7101	T7102	det	a,signal
R4546	T7102	T7099	appos	signal,protein
R4547	T7103	T7102	amod	diffusible,signal
R4548	T7104	T7102	acl	made,signal
R4549	T7105	T7104	prep	in,made
R4550	T7106	T7107	det	the,surface
R4551	T7107	T7105	pobj	surface,in
R4552	T7108	T7107	amod	articular,surface
R4553	T7109	T7094	punct	", ",inhibit
R4554	T7110	T7094	aux	may,inhibit
R4555	T7111	T7094	advmod	normally,inhibit
R4556	T7112	T7094	dobj	maturation,inhibit
R4557	T7113	T7112	prep	of,maturation
R4558	T7114	T7115	amod	underlying,cartilage
R4559	T7115	T7113	pobj	cartilage,of
R4560	T7116	T7117	punct	(,Vortkamp
R4561	T7117	T7092	meta	Vortkamp,suggest
R4562	T7118	T7117	nmod	et,Vortkamp
R4563	T7119	T7117	nmod	al.,Vortkamp
R4564	T7120	T7117	nummod	1996,Vortkamp
R4565	T7121	T7117	punct	;,Vortkamp
R4566	T7122	T7117	nmod	Weir,Vortkamp
R4567	T7123	T7117	nmod	et,Vortkamp
R4568	T7124	T7117	nmod	al.,Vortkamp
R4569	T7125	T7117	nummod	1996,Vortkamp
R4570	T7126	T7117	punct	),Vortkamp
R4571	T7127	T7092	punct	.,suggest
R4572	T7129	T7130	amod	Local,loss
R4573	T7130	T7131	nsubj	loss,remove
R4574	T7132	T7130	prep	of,loss
R4575	T7133	T7134	det	the,surface
R4576	T7134	T7132	pobj	surface,of
R4577	T7135	T7134	amod	articular,surface
R4578	T7136	T7131	aux	could,remove
R4579	T7137	T7138	det	this,inhibition
R4580	T7138	T7131	dobj	inhibition,remove
R4581	T7139	T7131	cc	and,remove
R4582	T7140	T7131	conj	lead,remove
R4583	T7141	T7140	prep	to,lead
R4584	T7142	T7143	det	a,acceleration
R4585	T7143	T7141	pobj	acceleration,to
R4586	T7144	T7145	npadvmod	cell,nonautonomous
R4587	T7145	T7143	amod	nonautonomous,acceleration
R4588	T7146	T7145	punct	-,nonautonomous
R4589	T7147	T7143	prep	of,acceleration
R4590	T7148	T7147	pobj	maturation,of
R4591	T7149	T7140	prep	in,lead
R4592	T7150	T7149	pobj	chondrocytes,in
R4593	T7151	T7150	acl	underlying,chondrocytes
R4594	T7152	T7151	dobj	points,underlying
R4595	T7153	T7152	prep	of,points
R4596	T7154	T7155	amod	articular,erosion
R4597	T7155	T7153	pobj	erosion,of
R4598	T7156	T7131	punct	.,remove
R4599	T7158	T7159	det	This,hypertrophy
R4600	T7159	T7161	nsubjpass	hypertrophy,associated
R4601	T7160	T7159	amod	synovial,hypertrophy
R4602	T7162	T7161	auxpass	is,associated
R4603	T7163	T7161	prep	with,associated
R4604	T7164	T7165	amod	increased,numbers
R4605	T7165	T7163	pobj	numbers,with
R4606	T7166	T7165	prep	of,numbers
R4607	T7167	T7168	amod	mononuclear,cells
R4608	T7168	T7166	pobj	cells,of
R4609	T7169	T7168	acl	resembling,cells
R4610	T7170	T7169	dobj	synoviocytes,resembling
R4611	T7171	T7170	cc	or,synoviocytes
R4612	T7172	T7170	conj	macrophages,synoviocytes
R4613	T7173	T7170	punct	", ",synoviocytes
R4614	T7174	T7175	compound	cell,types
R4615	T7175	T7170	appos	types,synoviocytes
R4616	T7176	T7177	dep	that,are
R4617	T7177	T7175	relcl	are,types
R4618	T7178	T7177	acomp	difficult,are
R4619	T7179	T7180	aux	to,distinguish
R4620	T7180	T7178	advcl	distinguish,difficult
R4621	T7181	T7182	advmod	even,with
R4622	T7182	T7180	prep	with,distinguish
R4623	T7183	T7184	compound	surface,markers
R4624	T7184	T7182	pobj	markers,with
R4625	T7185	T7177	prep	at,are
R4626	T7186	T7187	amod	early,stages
R4627	T7187	T7185	pobj	stages,at
R4628	T7188	T7187	amod	postnatal,stages
R4629	T7189	T7161	punct	.,associated
R4630	T7191	T7192	advmod	However,observed
R4631	T7193	T7192	punct	", ",observed
R4632	T7194	T7195	det	no,neutrophils
R4633	T7195	T7192	nsubjpass	neutrophils,observed
R4634	T7196	T7192	auxpass	were,observed
R4635	T7197	T7192	punct	", ",observed
R4636	T7198	T7192	advcl	suggesting,observed
R4637	T7199	T7200	mark	that,is
R4638	T7200	T7198	ccomp	is,suggesting
R4639	T7201	T7200	expl	there,is
R4640	T7202	T7203	amod	little,inflammation
R4641	T7203	T7200	attr	inflammation,is
R4642	T7204	T7192	punct	.,observed
R4643	T7206	T7207	prep	At,reduced
R4644	T7208	T7209	amod	later,stages
R4645	T7209	T7206	pobj	stages,At
R4646	T7210	T7211	amod	synovial,hypertrophy
R4647	T7211	T7207	nsubjpass	hypertrophy,reduced
R4648	T7212	T7207	auxpass	is,reduced
R4649	T7213	T7207	punct	.,reduced
R4650	T7215	T7216	amod	Further,work
R4651	T7216	T7217	nsubjpass	work,needed
R4652	T7218	T7217	aux	will,needed
R4653	T7219	T7217	auxpass	be,needed
R4654	T7220	T7221	aux	to,determine
R4655	T7221	T7217	advcl	determine,needed
R4656	T7222	T7223	mark	whether,regulated
R4657	T7223	T7221	advcl	regulated,determine
R4658	T7224	T7225	amod	synovial,development
R4659	T7225	T7223	nsubjpass	development,regulated
R4660	T7226	T7223	auxpass	is,regulated
R4661	T7227	T7223	agent	by,regulated
R4662	T7228	T7229	compound	BMP,signaling
R4663	T7229	T7227	pobj	signaling,by
R4664	T7230	T7223	punct	", ",regulated
R4665	T7231	T7223	cc	or,regulated
R4666	T7232	T7233	mark	whether,becomes
R4667	T7233	T7223	conj	becomes,regulated
R4668	T7234	T7235	det	the,synovium
R4669	T7235	T7233	nsubj	synovium,becomes
R4670	T7236	T7233	acomp	enlarged,becomes
R4671	T7237	T7233	prep	as,becomes
R4672	T7238	T7239	det	a,response
R4673	T7239	T7237	pobj	response,as
R4674	T7240	T7239	prep	to,response
R4675	T7241	T7242	amod	nearby,malformations
R4676	T7242	T7240	pobj	malformations,to
R4677	T7243	T7242	amod	skeletal,malformations
R4678	T7244	T7242	punct	(,malformations
R4679	T7245	T7246	amod	such,as
R4680	T7246	T7242	prep	as,malformations
R4681	T7247	T7246	pobj	fusion,as
R4682	T7248	T7247	prep	of,fusion
R4683	T7249	T7250	det	the,tarsals
R4684	T7250	T7248	pobj	tarsals,of
R4685	T7251	T7250	amod	second,tarsals
R4686	T7252	T7251	cc	and,second
R4687	T7253	T7251	conj	central,second
R4688	T7254	T7247	cc	or,fusion
R4689	T7255	T7247	conj	defects,fusion
R4690	T7256	T7255	prep	in,defects
R4691	T7257	T7258	det	the,cartilage
R4692	T7258	T7256	pobj	cartilage,in
R4693	T7259	T7258	amod	articular,cartilage
R4694	T7260	T7242	punct	),malformations
R4695	T7261	T7217	punct	.,needed
R4702	T7528	T7529	amod	Noninflammatory,Degeneration
R4703	T7530	T7529	prep	of,Degeneration
R4704	T7531	T7532	amod	Articular,Cartilage
R4705	T7532	T7530	pobj	Cartilage,of
R4706	T7533	T7529	prep	in,Degeneration
R4707	T7534	T7535	nmod	Digit,Joints
R4708	T7535	T7533	pobj	Joints,in
R4709	T7536	T7534	cc	and,Digit
R4710	T7537	T7534	conj	Knee,Digit
R4711	T7539	T7540	prep	Outside,seen
R4712	T7541	T7539	prep	of,Outside
R4713	T7542	T7543	det	the,region
R4714	T7543	T7541	pobj	region,of
R4715	T7544	T7543	compound	ankle,region
R4716	T7545	T7540	punct	", ",seen
R4717	T7546	T7540	nsubjpass	little,seen
R4718	T7547	T7546	cc	or,little
R4719	T7548	T7549	nmod	no,evidence
R4720	T7549	T7546	conj	evidence,little
R4721	T7550	T7540	auxpass	was,seen
R4722	T7551	T7540	prep	for,seen
R4723	T7552	T7551	pobj	expansion,for
R4724	T7553	T7552	prep	of,expansion
R4725	T7554	T7555	det	the,membrane
R4726	T7555	T7553	pobj	membrane,of
R4727	T7556	T7555	amod	synovial,membrane
R4728	T7557	T7540	punct	.,seen
R4729	T7559	T7560	advmod	Instead,showed
R4730	T7561	T7560	punct	", ",showed
R4731	T7562	T7563	compound	mutant,mice
R4732	T7563	T7560	nsubj	mice,showed
R4733	T7564	T7565	amod	histological,signs
R4734	T7565	T7560	dobj	signs,showed
R4735	T7566	T7565	prep	of,signs
R4736	T7567	T7566	pobj	osteoarthritis,of
R4737	T7568	T7565	punct	", ",signs
R4738	T7569	T7570	amod	such,as
R4739	T7570	T7565	prep	as,signs
R4740	T7571	T7570	pobj	fibrillation,as
R4741	T7572	T7571	prep	of,fibrillation
R4742	T7573	T7574	det	the,surface
R4743	T7574	T7572	pobj	surface,of
R4744	T7575	T7574	amod	articular,surface
R4745	T7576	T7577	punct	(,Figure
R4746	T7577	T7560	parataxis	Figure,showed
R4747	T7578	T7577	nummod	7,Figure
R4748	T7579	T7577	punct	),Figure
R4749	T7580	T7560	punct	.,showed
R4750	T7582	T7583	mark	As,seen
R4751	T7583	T7585	advcl	seen,reduced
R4752	T7584	T7583	advmod	previously,seen
R4753	T7586	T7583	prep	in,seen
R4754	T7587	T7588	nummod	1,wk
R4755	T7588	T7593	npadvmod	wk,old
R4756	T7589	T7587	punct	-,1
R4757	T7590	T7587	cc	and,1
R4758	T7591	T7587	conj	2,1
R4759	T7592	T7591	punct	-,2
R4760	T7593	T7595	amod	old,animals
R4761	T7594	T7593	punct	-,old
R4762	T7595	T7586	pobj	animals,in
R4763	T7596	T7585	punct	", ",reduced
R4764	T7597	T7598	compound	Safranin,O
R4765	T7598	T7599	compound	O,staining
R4766	T7599	T7585	nsubjpass	staining,reduced
R4767	T7600	T7599	cc	and,staining
R4768	T7601	T7602	nmod	Agg,expression
R4769	T7602	T7599	conj	expression,staining
R4770	T7603	T7601	cc	and,Agg
R4771	T7604	T7601	conj	Col10,Agg
R4772	T7605	T7585	auxpass	were,reduced
R4773	T7606	T7585	advmod	all,reduced
R4774	T7607	T7585	prep	in,reduced
R4775	T7608	T7609	nmod	mutant,regions
R4776	T7609	T7607	pobj	regions,in
R4777	T7610	T7609	amod	articular,regions
R4778	T7611	T7609	prep	of,regions
R4779	T7612	T7613	det	the,forefeet
R4780	T7613	T7611	pobj	forefeet,of
R4781	T7614	T7613	cc	and,forefeet
R4782	T7615	T7613	conj	hindfeet,forefeet
R4783	T7616	T7585	prep	by,reduced
R4784	T7617	T7618	nummod	7,wk
R4785	T7618	T7616	pobj	wk,by
R4786	T7619	T7618	prep	of,wk
R4787	T7620	T7619	pobj	age,of
R4788	T7621	T7585	punct	", ",reduced
R4789	T7622	T7585	cc	and,reduced
R4790	T7623	T7624	det	the,signs
R4791	T7624	T7626	nsubjpass	signs,observed
R4792	T7625	T7624	compound	beginning,signs
R4793	T7626	T7585	conj	observed,reduced
R4794	T7627	T7624	prep	of,signs
R4795	T7628	T7629	compound	cartilage,loss
R4796	T7629	T7627	pobj	loss,of
R4797	T7630	T7626	auxpass	were,observed
R4798	T7631	T7632	punct	(,data
R4799	T7632	T7626	meta	data,observed
R4800	T7633	T7632	amod	unpublished,data
R4801	T7634	T7632	punct	),data
R4802	T7635	T7626	punct	.,observed
R4803	T7637	T7638	prep	By,were
R4804	T7639	T7640	nummod	9,mo
R4805	T7640	T7637	pobj	mo,By
R4806	T7641	T7640	prep	of,mo
R4807	T7642	T7641	pobj	age,of
R4808	T7643	T7638	punct	", ",were
R4809	T7644	T7645	amod	many,regions
R4810	T7645	T7638	nsubj	regions,were
R4811	T7646	T7645	prep	of,regions
R4812	T7647	T7648	amod	articular,cartilage
R4813	T7648	T7646	pobj	cartilage,of
R4814	T7649	T7650	advmod	completely,missing
R4815	T7650	T7638	acomp	missing,were
R4816	T7651	T7650	cc	or,missing
R4817	T7652	T7653	advmod	extremely,fibrillated
R4818	T7653	T7650	conj	fibrillated,missing
R4819	T7654	T7638	punct	", ",were
R4820	T7655	T7638	advcl	leaving,were
R4821	T7656	T7655	dobj	regions,leaving
R4822	T7657	T7656	prep	of,regions
R4823	T7658	T7659	amod	exposed,bone
R4824	T7659	T7657	pobj	bone,of
R4825	T7660	T7655	prep	on,leaving
R4826	T7661	T7662	det	the,surface
R4827	T7662	T7660	pobj	surface,on
R4828	T7663	T7664	punct	(,7A
R4829	T7664	T7638	parataxis	7A,were
R4830	T7665	T7664	nmod	Figure,7A
R4831	T7666	T7667	punct	–,7D
R4832	T7667	T7664	prep	7D,7A
R4833	T7668	T7664	punct	),7A
R4834	T7669	T7638	punct	.,were
R4835	T7671	T7672	det	No,alterations
R4836	T7672	T7673	nsubjpass	alterations,seen
R4837	T7674	T7673	auxpass	were,seen
R4838	T7675	T7673	prep	in,seen
R4839	T7676	T7677	det	the,expression
R4840	T7677	T7675	pobj	expression,in
R4841	T7678	T7677	prep	of,expression
R4842	T7679	T7678	pobj	Osteocalcin,of
R4843	T7680	T7679	punct	", ",Osteocalcin
R4844	T7681	T7679	conj	Col1a1,Osteocalcin
R4845	T7682	T7681	punct	", ",Col1a1
R4846	T7683	T7681	cc	or,Col1a1
R4847	T7684	T7685	compound	matrix,metalloprotease
R4848	T7685	T7681	conj	metalloprotease,Col1a1
R4849	T7686	T7685	punct	-,metalloprotease
R4850	T7687	T7685	nummod	13,metalloprotease
R4851	T7688	T7673	prep	at,seen
R4852	T7689	T7690	preconj	either,wk
R4853	T7690	T7688	pobj	wk,at
R4854	T7691	T7690	nummod	7,wk
R4855	T7692	T7690	cc	or,wk
R4856	T7693	T7694	nummod	9,mo
R4857	T7694	T7690	conj	mo,wk
R4858	T7695	T7673	punct	.,seen
R4859	T7697	T7698	det	The,joint
R4860	T7698	T7703	nsubj	joint,showed
R4861	T7699	T7698	amod	major,joint
R4862	T7700	T7698	nmod	weight,joint
R4863	T7701	T7700	punct	-,weight
R4864	T7702	T7700	amod	bearing,weight
R4865	T7704	T7698	prep	of,joint
R4866	T7705	T7706	det	the,hindlimb
R4867	T7706	T7704	pobj	hindlimb,of
R4868	T7707	T7698	punct	", ",joint
R4869	T7708	T7709	det	the,knee
R4870	T7709	T7698	appos	knee,joint
R4871	T7710	T7703	punct	", ",showed
R4872	T7711	T7703	dobj	changes,showed
R4873	T7712	T7713	dep	that,paralleled
R4874	T7713	T7711	relcl	paralleled,changes
R4875	T7714	T7713	advmod	closely,paralleled
R4876	T7715	T7713	dobj	that,paralleled
R4877	T7716	T7715	acl	seen,that
R4878	T7717	T7716	prep	in,seen
R4879	T7718	T7719	det	the,joints
R4880	T7719	T7717	pobj	joints,in
R4881	T7720	T7719	compound	foot,joints
R4882	T7721	T7703	punct	.,showed
R4883	T7723	T7724	det	All,markers
R4884	T7724	T7725	nsubj	markers,looked
R4885	T7726	T7724	prep	of,markers
R4886	T7727	T7728	compound	cartilage,matrix
R4887	T7728	T7726	pobj	matrix,of
R4888	T7729	T7725	acomp	similar,looked
R4889	T7730	T7729	prep	to,similar
R4890	T7731	T7730	pobj	controls,to
R4891	T7732	T7725	prep	at,looked
R4892	T7733	T7732	pobj	E16.5,at
R4893	T7734	T7725	punct	", ",looked
R4894	T7735	T7725	advcl	suggesting,looked
R4895	T7736	T7737	mark	that,disrupted
R4896	T7737	T7735	ccomp	disrupted,suggesting
R4897	T7738	T7739	amod	early,stages
R4898	T7739	T7737	nsubjpass	stages,disrupted
R4899	T7740	T7739	prep	of,stages
R4900	T7741	T7742	compound	joint,formation
R4901	T7742	T7740	pobj	formation,of
R4902	T7743	T7737	auxpass	were,disrupted
R4903	T7744	T7737	neg	not,disrupted
R4904	T7745	T7746	punct	(,data
R4905	T7746	T7725	meta	data,looked
R4906	T7747	T7746	amod	unpublished,data
R4907	T7748	T7746	punct	),data
R4908	T7749	T7725	punct	.,looked
R4909	T7751	T7752	prep	By,reduced
R4910	T7753	T7754	amod	postnatal,day
R4911	T7754	T7751	pobj	day,By
R4912	T7755	T7754	nummod	7,day
R4913	T7756	T7752	punct	", ",reduced
R4914	T7757	T7758	compound	Safranin,O
R4915	T7758	T7759	compound	O,staining
R4916	T7759	T7752	nsubjpass	staining,reduced
R4917	T7760	T7759	cc	and,staining
R4918	T7761	T7762	nmod	Col2a1,expression
R4919	T7762	T7759	conj	expression,staining
R4920	T7763	T7761	cc	and,Col2a1
R4921	T7764	T7761	conj	Agg,Col2a1
R4922	T7765	T7752	auxpass	were,reduced
R4923	T7766	T7752	advmod	clearly,reduced
R4924	T7767	T7752	prep	in,reduced
R4925	T7768	T7769	det	the,mutant
R4926	T7769	T7767	pobj	mutant,in
R4927	T7770	T7752	punct	", ",reduced
R4928	T7771	T7752	prep	despite,reduced
R4929	T7772	T7773	amod	continued,expression
R4930	T7773	T7771	pobj	expression,despite
R4931	T7774	T7773	prep	of,expression
R4932	T7775	T7774	pobj	Sox9,of
R4933	T7776	T7777	punct	(,data
R4934	T7777	T7752	meta	data,reduced
R4935	T7778	T7777	amod	unpublished,data
R4936	T7779	T7777	punct	),data
R4937	T7780	T7752	punct	.,reduced
R4938	T7782	T7783	det	The,shape
R4939	T7783	T7785	nsubj	shape,appeared
R4940	T7784	T7783	amod	overall,shape
R4941	T7786	T7783	prep	of,shape
R4942	T7787	T7788	nmod	mutant,knee
R4943	T7788	T7789	nmod	knee,elements
R4944	T7789	T7786	pobj	elements,of
R4945	T7790	T7789	amod	skeletal,elements
R4946	T7791	T7785	oprd	similar,appeared
R4947	T7792	T7791	prep	to,similar
R4948	T7793	T7792	pobj	controls,to
R4949	T7794	T7785	punct	", ",appeared
R4950	T7795	T7796	mark	although,appeared
R4951	T7796	T7785	advcl	appeared,appeared
R4952	T7797	T7798	det	the,meniscus
R4953	T7798	T7796	nsubj	meniscus,appeared
R4954	T7799	T7798	compound	fibrocartilaginous,meniscus
R4955	T7800	T7801	dep	that,resides
R4956	T7801	T7798	relcl	resides,meniscus
R4957	T7802	T7801	prep	between,resides
R4958	T7803	T7804	det	the,femur
R4959	T7804	T7802	pobj	femur,between
R4960	T7805	T7804	cc	and,femur
R4961	T7806	T7804	conj	tibia,femur
R4962	T7807	T7808	advmod	much,less
R4963	T7808	T7809	advmod	less,dense
R4964	T7809	T7796	oprd	dense,appeared
R4965	T7810	T7796	prep	in,appeared
R4966	T7811	T7810	pobj	mutants,in
R4967	T7812	T7796	prep	at,appeared
R4968	T7813	T7812	pobj	E16.5,at
R4969	T7814	T7785	punct	.,appeared
R4970	T7816	T7817	det	Some,cartilage
R4971	T7817	T7818	nsubj	cartilage,formed
R4972	T7819	T7818	prep	in,formed
R4973	T7820	T7821	det	the,region
R4974	T7821	T7819	pobj	region,in
R4975	T7822	T7821	compound	meniscus,region
R4976	T7823	T7818	punct	", ",formed
R4977	T7824	T7818	cc	but,formed
R4978	T7825	T7826	det	the,size
R4979	T7826	T7827	nsubjpass	size,reduced
R4980	T7827	T7818	conj	reduced,formed
R4981	T7828	T7826	prep	of,size
R4982	T7829	T7830	det	these,elements
R4983	T7830	T7828	pobj	elements,of
R4984	T7831	T7827	auxpass	was,reduced
R4985	T7832	T7827	advmod	greatly,reduced
R4986	T7833	T7827	cc	and,reduced
R4987	T7834	T7827	conj	contained,reduced
R4988	T7835	T7836	amod	abundant,cells
R4989	T7836	T7834	dobj	cells,contained
R4990	T7837	T7836	prep	with,cells
R4991	T7838	T7839	amod	fibrous,appearance
R4992	T7839	T7837	pobj	appearance,with
R4993	T7840	T7839	punct	", ",appearance
R4994	T7841	T7839	amod	noncartilaginous,appearance
R4995	T7842	T7843	punct	(,data
R4996	T7843	T7834	meta	data,contained
R4997	T7844	T7843	amod	unpublished,data
R4998	T7845	T7843	punct	),data
R4999	T7846	T7827	punct	.,reduced
R5000	T7848	T7849	det	This,reduction
R5001	T7849	T7850	nsubjpass	reduction,seen
R5002	T7851	T7849	prep	of,reduction
R5003	T7852	T7853	det	the,meniscus
R5004	T7853	T7851	pobj	meniscus,of
R5005	T7854	T7850	aux	can,seen
R5006	T7855	T7850	advmod	also,seen
R5007	T7856	T7850	auxpass	be,seen
R5008	T7857	T7850	prep	in,seen
R5009	T7858	T7857	pobj	sections,in
R5010	T7859	T7858	prep	from,sections
R5011	T7860	T7861	nummod	7,wk
R5012	T7861	T7863	npadvmod	wk,old
R5013	T7862	T7861	punct	-,wk
R5014	T7863	T7870	amod	old,animals
R5015	T7864	T7861	punct	-,wk
R5016	T7865	T7861	cc	and,wk
R5017	T7866	T7867	nummod	9,mo
R5018	T7867	T7861	conj	mo,wk
R5019	T7868	T7867	punct	-,mo
R5020	T7869	T7863	punct	-,old
R5021	T7870	T7859	pobj	animals,from
R5022	T7871	T7872	punct	(,arrows
R5023	T7872	T7850	parataxis	arrows,seen
R5024	T7873	T7872	dep	Figure,arrows
R5025	T7874	T7873	nummod	7E,Figure
R5026	T7875	T7873	punct	", ",Figure
R5027	T7876	T7873	nummod	7H,Figure
R5028	T7877	T7873	punct	", ",Figure
R5029	T7878	T7873	nummod	7K,Figure
R5030	T7879	T7873	punct	", ",Figure
R5031	T7880	T7873	cc	and,Figure
R5032	T7881	T7873	conj	7N,Figure
R5033	T7882	T7872	punct	", ",arrows
R5034	T7883	T7872	punct	),arrows
R5035	T7884	T7850	punct	.,seen
R5036	T7886	T7887	prep	At,flattened
R5037	T7888	T7889	nummod	7,wk
R5038	T7889	T7886	pobj	wk,At
R5039	T7890	T7889	prep	of,wk
R5040	T7891	T7890	pobj	age,of
R5041	T7892	T7893	det	the,epiphysis
R5042	T7893	T7887	nsubjpass	epiphysis,flattened
R5043	T7894	T7895	advmod	normally,domed
R5044	T7895	T7893	amod	domed,epiphysis
R5045	T7896	T7893	amod	tibial,epiphysis
R5046	T7897	T7887	auxpass	was,flattened
R5047	T7898	T7887	cc	and,flattened
R5048	T7899	T7887	conj	depressed,flattened
R5049	T7900	T7899	prep	in,depressed
R5050	T7901	T7902	det	the,knees
R5051	T7902	T7900	pobj	knees,in
R5052	T7903	T7902	prep	of,knees
R5053	T7904	T7905	compound	mutant,animals
R5054	T7905	T7903	pobj	animals,of
R5055	T7906	T7899	punct	", ",depressed
R5056	T7907	T7908	advmod	markedly,reducing
R5057	T7908	T7899	conj	reducing,depressed
R5058	T7909	T7910	det	the,distance
R5059	T7910	T7908	dobj	distance,reducing
R5060	T7911	T7910	prep	between,distance
R5061	T7912	T7913	det	the,plate
R5062	T7913	T7911	pobj	plate,between
R5063	T7914	T7913	compound	growth,plate
R5064	T7915	T7913	cc	and,plate
R5065	T7916	T7917	amod	articular,surface
R5066	T7917	T7913	conj	surface,plate
R5067	T7918	T7919	punct	(,bar
R5068	T7919	T7908	parataxis	bar,reducing
R5069	T7920	T7919	dep	Figure,bar
R5070	T7921	T7920	nummod	7E,Figure
R5071	T7922	T7920	cc	and,Figure
R5072	T7923	T7920	conj	7H,Figure
R5073	T7924	T7919	punct	", ",bar
R5074	T7925	T7919	amod	vertical,bar
R5075	T7926	T7919	punct	),bar
R5076	T7927	T7887	punct	.,flattened
R5077	T7929	T7930	amod	Articular,cartilage
R5078	T7930	T7931	nsubj	cartilage,was
R5079	T7932	T7931	advmod	also,was
R5080	T7933	T7931	acomp	thinner,was
R5081	T7934	T7933	prep	than,thinner
R5082	T7935	T7934	prep	in,than
R5083	T7936	T7937	compound	control,animals
R5084	T7937	T7935	pobj	animals,in
R5085	T7938	T7931	punct	", ",was
R5086	T7939	T7931	conj	showed,was
R5087	T7940	T7941	advmod	nearly,complete
R5088	T7941	T7942	amod	complete,absence
R5089	T7942	T7939	dobj	absence,showed
R5090	T7943	T7942	prep	of,absence
R5091	T7944	T7945	compound	Safranin,O
R5092	T7945	T7946	compound	O,staining
R5093	T7946	T7943	pobj	staining,of
R5094	T7947	T7939	punct	", ",showed
R5095	T7948	T7939	cc	and,showed
R5096	T7949	T7939	conj	was,showed
R5097	T7950	T7951	preconj	either,acellular
R5098	T7951	T7949	acomp	acellular,was
R5099	T7952	T7951	cc	or,acellular
R5100	T7953	T7951	conj	beginning,acellular
R5101	T7954	T7955	aux	to,fibrillate
R5102	T7955	T7953	xcomp	fibrillate,beginning
R5103	T7956	T7953	prep	in,beginning
R5104	T7957	T7958	amod	many,regions
R5105	T7958	T7956	pobj	regions,in
R5106	T7959	T7960	punct	(,Figure
R5107	T7960	T7949	parataxis	Figure,was
R5108	T7961	T7960	nummod	7F,Figure
R5109	T7962	T7960	cc	and,Figure
R5110	T7963	T7960	conj	7I,Figure
R5111	T7964	T7960	punct	),Figure
R5112	T7965	T7931	punct	.,was
R5113	T7967	T7968	det	The,cells
R5114	T7968	T7975	nsubj	cells,appeared
R5115	T7969	T7968	amod	few,cells
R5116	T7970	T7968	amod	large,cells
R5117	T7971	T7972	compound	Safranin,O
R5118	T7972	T7973	npadvmod	O,stained
R5119	T7973	T7968	amod	stained,cells
R5120	T7974	T7973	punct	-,stained
R5121	T7976	T7977	advmod	still,apparent
R5122	T7977	T7968	relcl	apparent,cells
R5123	T7978	T7977	prep	in,apparent
R5124	T7979	T7980	nmod	mutant,regions
R5125	T7980	T7978	pobj	regions,in
R5126	T7981	T7980	amod	articular,regions
R5127	T7982	T7983	aux	to,correspond
R5128	T7983	T7975	xcomp	correspond,appeared
R5129	T7984	T7983	prep	in,correspond
R5130	T7985	T7984	pobj	position,in
R5131	T7986	T7983	prep	to,correspond
R5132	T7987	T7988	amod	rare,cells
R5133	T7988	T7986	pobj	cells,to
R5134	T7989	T7990	npadvmod	LACZ,negative
R5135	T7990	T7988	amod	negative,cells
R5136	T7991	T7990	punct	-,negative
R5137	T7992	T7988	prep	in,cells
R5138	T7993	T7994	amod	adjacent,sections
R5139	T7994	T7992	pobj	sections,in
R5140	T7995	T7975	punct	", ",appeared
R5141	T7996	T7975	advcl	suggesting,appeared
R5142	T7997	T7998	mark	that,required
R5143	T7998	T7996	ccomp	required,suggesting
R5144	T7999	T7998	nsubjpass	Bmpr1a,required
R5145	T8000	T7998	auxpass	is,required
R5146	T8001	T8002	npadvmod	cell,autonomously
R5147	T8002	T7998	advmod	autonomously,required
R5148	T8003	T8002	punct	-,autonomously
R5149	T8004	T7998	prep	in,required
R5150	T8005	T8006	amod	articular,cartilage
R5151	T8006	T8004	pobj	cartilage,in
R5152	T8007	T8008	punct	(,arrowheads
R5153	T8008	T7975	parataxis	arrowheads,appeared
R5154	T8009	T8008	dep	Figure,arrowheads
R5155	T8010	T8009	nummod	7I,Figure
R5156	T8011	T8009	cc	and,Figure
R5157	T8012	T8009	conj	7J,Figure
R5158	T8013	T8008	punct	", ",arrowheads
R5159	T8014	T8008	amod	white,arrowheads
R5160	T8015	T8008	punct	),arrowheads
R5161	T8016	T7975	punct	.,appeared
R5162	T8018	T8019	prep	By,were
R5163	T8020	T8021	nummod	9,mo
R5164	T8021	T8018	pobj	mo,By
R5165	T8022	T8019	punct	", ",were
R5166	T8023	T8024	amod	large,areas
R5167	T8024	T8019	nsubj	areas,were
R5168	T8025	T8024	prep	of,areas
R5169	T8026	T8027	compound	mutant,knees
R5170	T8027	T8025	pobj	knees,of
R5171	T8028	T8019	acomp	devoid,were
R5172	T8029	T8028	prep	of,devoid
R5173	T8030	T8031	amod	articular,cells
R5174	T8031	T8029	pobj	cells,of
R5175	T8032	T8019	punct	", ",were
R5176	T8033	T8019	cc	and,were
R5177	T8034	T8035	det	the,bones
R5178	T8035	T8036	nsubj	bones,appeared
R5179	T8036	T8019	conj	appeared,were
R5180	T8037	T8035	prep	of,bones
R5181	T8038	T8039	det	the,femur
R5182	T8039	T8037	pobj	femur,of
R5183	T8040	T8039	cc	and,femur
R5184	T8041	T8039	conj	tibia,femur
R5185	T8042	T8043	aux	to,rub
R5186	T8043	T8036	xcomp	rub,appeared
R5187	T8044	T8043	advmod	directly,rub
R5188	T8045	T8043	prep	against,rub
R5189	T8046	T8047	det	each,other
R5190	T8047	T8045	pobj	other,against
R5191	T8048	T8036	punct	.,appeared
R5192	T8050	T8051	advmod	Furthermore,was
R5193	T8052	T8051	punct	", ",was
R5194	T8053	T8054	det	the,epiphysis
R5195	T8054	T8051	nsubj	epiphysis,was
R5196	T8055	T8054	prep	of,epiphysis
R5197	T8056	T8057	det	the,tibia
R5198	T8057	T8055	pobj	tibia,of
R5199	T8058	T8051	advmod	extremely,was
R5200	T8059	T8051	acomp	depressed,was
R5201	T8060	T8051	punct	", ",was
R5202	T8061	T8051	prep	to,was
R5203	T8062	T8063	det	the,point
R5204	T8063	T8061	pobj	point,to
R5205	T8064	T8065	mark	that,exposed
R5206	T8065	T8063	acl	exposed,point
R5207	T8066	T8067	compound	growth,cartilage
R5208	T8067	T8065	nsubjpass	cartilage,exposed
R5209	T8068	T8067	compound	plate,cartilage
R5210	T8069	T8065	auxpass	was,exposed
R5211	T8070	T8065	advmod	almost,exposed
R5212	T8071	T8065	prep	through,exposed
R5213	T8072	T8073	det	the,surface
R5214	T8073	T8071	pobj	surface,through
R5215	T8074	T8073	prep	of,surface
R5216	T8075	T8076	det	the,bone
R5217	T8076	T8074	pobj	bone,of
R5218	T8077	T8078	punct	(,7K
R5219	T8078	T8051	parataxis	7K,was
R5220	T8079	T8078	nmod	Figure,7K
R5221	T8080	T8078	punct	", ",7K
R5222	T8081	T8078	conj	7L,7K
R5223	T8082	T8081	punct	", ",7L
R5224	T8083	T8081	conj	7N,7L
R5225	T8084	T8083	punct	", ",7N
R5226	T8085	T8083	cc	and,7N
R5227	T8086	T8083	conj	7O,7N
R5228	T8087	T8078	punct	),7K
R5229	T8088	T8051	punct	.,was
R5230	T8090	T8091	prep	In,showed
R5231	T8092	T8090	pobj	addition,In
R5232	T8093	T8091	punct	", ",showed
R5233	T8094	T8091	nsubj	mutants,showed
R5234	T8095	T8094	prep	at,mutants
R5235	T8096	T8097	nummod	7,wk
R5236	T8097	T8095	pobj	wk,at
R5237	T8098	T8097	cc	and,wk
R5238	T8099	T8100	nummod	9,mo
R5239	T8100	T8097	conj	mo,wk
R5240	T8101	T8102	amod	subchondral,sclerosis
R5241	T8102	T8091	dobj	sclerosis,showed
R5242	T8103	T8091	punct	", ",showed
R5243	T8104	T8105	advmod	especially,in
R5244	T8105	T8091	prep	in,showed
R5245	T8106	T8107	det	the,epiphysis
R5246	T8107	T8105	pobj	epiphysis,in
R5247	T8108	T8107	prep	of,epiphysis
R5248	T8109	T8110	det	the,femur
R5249	T8110	T8108	pobj	femur,of
R5250	T8111	T8112	punct	(,asterisks
R5251	T8112	T8091	parataxis	asterisks,showed
R5252	T8113	T8114	nmod	Figure,7E
R5253	T8114	T8112	dep	7E,asterisks
R5254	T8115	T8114	punct	", ",7E
R5255	T8116	T8114	conj	7H,7E
R5256	T8117	T8116	punct	", ",7H
R5257	T8118	T8116	conj	7K,7H
R5258	T8119	T8118	punct	", ",7K
R5259	T8120	T8118	cc	and,7K
R5260	T8121	T8118	conj	7N,7K
R5261	T8122	T8112	punct	", ",asterisks
R5262	T8123	T8112	punct	),asterisks
R5263	T8124	T8091	punct	.,showed
R5264	T8126	T8127	mark	While,seen
R5265	T8127	T8132	advcl	seen,is
R5266	T8128	T8129	amod	subchondral,sclerosis
R5267	T8129	T8127	nsubjpass	sclerosis,seen
R5268	T8130	T8127	auxpass	is,seen
R5269	T8131	T8127	advmod	commonly,seen
R5270	T8133	T8127	prep	in,seen
R5271	T8134	T8133	pobj	cases,in
R5272	T8135	T8134	prep	of,cases
R5273	T8136	T8135	pobj	osteoarthritis,of
R5274	T8137	T8132	punct	", ",is
R5275	T8138	T8132	nsubj	it,is
R5276	T8139	T8132	acomp	unclear,is
R5277	T8140	T8132	prep	in,is
R5278	T8141	T8142	det	this,case
R5279	T8142	T8140	pobj	case,in
R5280	T8143	T8144	mark	whether,is
R5281	T8144	T8132	advcl	is,is
R5282	T8145	T8146	det	the,sclerosis
R5283	T8146	T8144	nsubj	sclerosis,is
R5284	T8147	T8144	advmod	mainly,is
R5285	T8148	T8149	det	a,response
R5286	T8149	T8144	attr	response,is
R5287	T8150	T8149	prep	of,response
R5288	T8151	T8152	compound	bone,formation
R5289	T8152	T8150	pobj	formation,of
R5290	T8153	T8154	aux	to,compensate
R5291	T8154	T8149	advcl	compensate,response
R5292	T8155	T8154	prep	for,compensate
R5293	T8156	T8157	amod	decreased,cartilage
R5294	T8157	T8155	pobj	cartilage,for
R5295	T8158	T8157	amod	articular,cartilage
R5296	T8159	T8144	punct	", ",is
R5297	T8160	T8144	cc	or,is
R5298	T8161	T8162	mark	whether,is
R5299	T8162	T8144	conj	is,is
R5300	T8163	T8162	nsubj	it,is
R5301	T8164	T8165	det	the,effect
R5302	T8165	T8162	attr	effect,is
R5303	T8166	T8165	prep	of,effect
R5304	T8167	T8166	pobj	loss,of
R5305	T8168	T8167	prep	of,loss
R5306	T8169	T8170	compound	Bmpr1a,signaling
R5307	T8170	T8168	pobj	signaling,of
R5308	T8171	T8165	prep	in,effect
R5309	T8172	T8173	det	some,cells
R5310	T8173	T8171	pobj	cells,in
R5311	T8174	T8175	npadvmod	LACZ,positive
R5312	T8175	T8173	amod	positive,cells
R5313	T8176	T8175	punct	-,positive
R5314	T8177	T8178	dep	that,observed
R5315	T8178	T8173	relcl	observed,cells
R5316	T8179	T8178	auxpass	are,observed
R5317	T8180	T8178	advmod	also,observed
R5318	T8181	T8178	prep	in,observed
R5319	T8182	T8183	det	these,regions
R5320	T8183	T8181	pobj	regions,in
R5321	T8184	T8185	punct	(,data
R5322	T8185	T8162	meta	data,is
R5323	T8186	T8185	amod	unpublished,data
R5324	T8187	T8185	punct	),data
R5325	T8188	T8132	punct	.,is
R5326	T8190	T8191	det	The,signs
R5327	T8191	T8193	nsubjpass	signs,accompanied
R5328	T8192	T8191	amod	histological,signs
R5329	T8194	T8191	prep	of,signs
R5330	T8195	T8196	compound	joint,arthritis
R5331	T8196	T8194	pobj	arthritis,of
R5332	T8197	T8193	auxpass	were,accompanied
R5333	T8198	T8193	agent	by,accompanied
R5334	T8199	T8200	amod	functional,impairments
R5335	T8200	T8198	pobj	impairments,by
R5336	T8201	T8200	prep	in,impairments
R5337	T8202	T8203	preconj	both,ability
R5338	T8203	T8201	pobj	ability,in
R5339	T8204	T8203	amod	grasping,ability
R5340	T8205	T8203	cc	and,ability
R5341	T8206	T8203	conj	range,ability
R5342	T8207	T8206	prep	of,range
R5343	T8208	T8207	pobj	motion,of
R5344	T8209	T8193	prep	in,accompanied
R5345	T8210	T8211	compound	mutant,animals
R5346	T8211	T8209	pobj	animals,in
R5347	T8212	T8193	punct	.,accompanied
R5348	T8214	T8215	compound	Gdf5,Cre
R5349	T8215	T8217	compound	Cre,Bmpr1afloxP
R5350	T8216	T8215	punct	-,Cre
R5351	T8217	T8219	npadvmod	Bmpr1afloxP,mutant
R5352	T8218	T8217	punct	/,Bmpr1afloxP
R5353	T8219	T8220	amod	mutant,animals
R5354	T8220	T8221	nsubj	animals,showed
R5355	T8222	T8223	det	a,ability
R5356	T8223	T8221	dobj	ability,showed
R5357	T8224	T8225	advmod	highly,significantly
R5358	T8225	T8226	advmod	significantly,reduced
R5359	T8226	T8223	amod	reduced,ability
R5360	T8227	T8228	aux	to,grasp
R5361	T8228	T8223	acl	grasp,ability
R5362	T8229	T8228	cc	and,grasp
R5363	T8230	T8228	conj	remain,grasp
R5364	T8231	T8230	oprd	suspended,remain
R5365	T8232	T8231	prep	on,suspended
R5366	T8233	T8234	det	a,rod
R5367	T8234	T8230	dobj	rod,remain
R5368	T8235	T8234	amod	slender,rod
R5369	T8236	T8237	punct	(,time
R5370	T8237	T8221	parataxis	time,showed
R5371	T8238	T8237	amod	mean,time
R5372	T8239	T8237	compound	suspension,time
R5373	T8240	T8237	punct	: ,time
R5374	T8241	T8242	nsubj	controls,s
R5375	T8242	T8246	dep	s,s
R5376	T8243	T8244	quantmod	38,6
R5377	T8244	T8242	nummod	6,s
R5378	T8245	T8244	punct	±,6
R5379	T8246	T8237	dep	s,time
R5380	T8247	T8242	punct	", ",s
R5381	T8248	T8249	nsubj	n,39
R5382	T8249	T8242	advcl	39,s
R5383	T8250	T8249	punct	=,39
R5384	T8251	T8246	punct	;,s
R5385	T8252	T8246	nsubj	mutants,s
R5386	T8253	T8254	quantmod	6,3
R5387	T8254	T8246	nummod	3,s
R5388	T8255	T8254	punct	±,3
R5389	T8256	T8246	punct	", ",s
R5390	T8257	T8258	nsubj	n,11
R5391	T8258	T8246	advcl	11,s
R5392	T8259	T8258	punct	=,11
R5393	T8260	T8246	punct	;,s
R5394	T8261	T8262	nsubj	p,0.0001
R5395	T8262	T8246	advcl	0.0001,s
R5396	T8263	T8262	punct	<,0.0001
R5397	T8264	T8237	punct	),time
R5398	T8265	T8221	punct	.,showed
R5399	T8267	T8268	compound	Mutant,mice
R5400	T8268	T8269	nsubj	mice,showed
R5401	T8270	T8269	advmod	also,showed
R5402	T8271	T8272	det	a,decrease
R5403	T8272	T8269	dobj	decrease,showed
R5404	T8273	T8272	amod	clear,decrease
R5405	T8274	T8272	prep	in,decrease
R5406	T8275	T8276	det	the,range
R5407	T8276	T8274	pobj	range,in
R5408	T8277	T8276	amod	maximum,range
R5409	T8278	T8276	prep	of,range
R5410	T8279	T8278	pobj	mobility,of
R5411	T8280	T8276	prep	of,range
R5412	T8281	T8282	nummod	two,joints
R5413	T8282	T8280	pobj	joints,of
R5414	T8283	T8282	amod	different,joints
R5415	T8284	T8282	prep	in,joints
R5416	T8285	T8286	det	the,digits
R5417	T8286	T8284	pobj	digits,in
R5418	T8287	T8269	punct	", ",showed
R5419	T8288	T8289	mark	as,assayed
R5420	T8289	T8269	advcl	assayed,showed
R5421	T8290	T8289	agent	by,assayed
R5422	T8291	T8292	amod	passive,manipulation
R5423	T8292	T8290	pobj	manipulation,by
R5424	T8293	T8294	punct	(,0.05
R5425	T8294	T8269	parataxis	0.05,showed
R5426	T8295	T8296	compound	MT,P1
R5427	T8296	T8298	compound	P1,joint
R5428	T8297	T8296	punct	/,P1
R5429	T8298	T8299	dep	joint,0.0003
R5430	T8299	T8294	dep	0.0003,0.05
R5431	T8300	T8299	punct	: ,0.0003
R5432	T8301	T8302	dep	controls,26
R5433	T8302	T8299	dep	26,0.0003
R5434	T8303	T8304	quantmod	100,0
R5435	T8304	T8306	nummod	0,°
R5436	T8305	T8304	punct	±,0
R5437	T8306	T8302	dep	°,26
R5438	T8307	T8302	punct	", ",26
R5439	T8308	T8302	nsubj	n,26
R5440	T8309	T8302	punct	=,26
R5441	T8310	T8299	punct	;,0.0003
R5442	T8311	T8312	dep	mutants,8
R5443	T8312	T8299	dep	8,0.0003
R5444	T8313	T8314	quantmod	82,3
R5445	T8314	T8316	nummod	3,°
R5446	T8315	T8314	punct	±,3
R5447	T8316	T8312	dep	°,8
R5448	T8317	T8312	punct	", ",8
R5449	T8318	T8312	nsubj	n,8
R5450	T8319	T8312	punct	=,8
R5451	T8320	T8299	punct	;,0.0003
R5452	T8321	T8299	nsubj	p,0.0003
R5453	T8322	T8299	punct	<,0.0003
R5454	T8323	T8294	punct	;,0.05
R5455	T8324	T8325	compound	P1,P2
R5456	T8325	T8327	compound	P2,joint
R5457	T8326	T8325	punct	/,P2
R5458	T8327	T8294	dep	joint,0.05
R5459	T8328	T8294	punct	: ,0.05
R5460	T8329	T8330	dep	controls,23
R5461	T8330	T8294	dep	23,0.05
R5462	T8331	T8332	quantmod	152,1
R5463	T8332	T8334	nummod	1,°
R5464	T8333	T8332	punct	±,1
R5465	T8334	T8330	dep	°,23
R5466	T8335	T8330	punct	", ",23
R5467	T8336	T8330	nsubj	n,23
R5468	T8337	T8330	punct	=,23
R5469	T8338	T8294	punct	;,0.05
R5470	T8339	T8340	dep	mutants,6
R5471	T8340	T8294	dep	6,0.05
R5472	T8341	T8342	quantmod	140,5
R5473	T8342	T8344	nummod	5,°
R5474	T8343	T8342	punct	±,5
R5475	T8344	T8340	dep	°,6
R5476	T8345	T8340	punct	", ",6
R5477	T8346	T8340	nsubj	n,6
R5478	T8347	T8340	punct	=,6
R5479	T8348	T8340	punct	;,6
R5480	T8349	T8294	nsubj	p,0.05
R5481	T8350	T8294	punct	<,0.05
R5482	T8351	T8294	punct	),0.05
R5483	T8352	T8269	punct	.,showed
R5484	T8354	T8355	det	The,changes
R5485	T8355	T8366	nsubj	changes,demonstrate
R5486	T8356	T8355	amod	structural,changes
R5487	T8357	T8356	punct	", ",structural
R5488	T8358	T8356	conj	histological,structural
R5489	T8359	T8358	punct	", ",histological
R5490	T8360	T8361	compound	marker,gene
R5491	T8361	T8362	compound	gene,expression
R5492	T8362	T8358	conj	expression,histological
R5493	T8363	T8362	punct	", ",expression
R5494	T8364	T8362	cc	and,expression
R5495	T8365	T8362	conj	functional,expression
R5496	T8367	T8355	prep	in,changes
R5497	T8368	T8369	compound	mutant,mice
R5498	T8369	T8367	pobj	mice,in
R5499	T8370	T8371	mark	that,required
R5500	T8371	T8366	ccomp	required,demonstrate
R5501	T8372	T8371	nsubjpass	BMPR1A,required
R5502	T8373	T8371	auxpass	is,required
R5503	T8374	T8371	prep	for,required
R5504	T8375	T8376	amod	normal,maintenance
R5505	T8376	T8374	pobj	maintenance,for
R5506	T8377	T8376	amod	postnatal,maintenance
R5507	T8378	T8376	prep	of,maintenance
R5508	T8379	T8380	amod	articular,cartilage
R5509	T8380	T8378	pobj	cartilage,of
R5510	T8381	T8366	punct	.,demonstrate
R5531	T9223	T9224	amod	Previous,studies
R5532	T9224	T9225	nsubj	studies,suggest
R5533	T9226	T9227	mark	that,involved
R5534	T9227	T9225	ccomp	involved,suggest
R5535	T9228	T9229	compound	BMP,signaling
R5536	T9229	T9227	nsubjpass	signaling,involved
R5537	T9230	T9227	auxpass	is,involved
R5538	T9231	T9227	prep	in,involved
R5539	T9232	T9233	det	a,number
R5540	T9233	T9231	pobj	number,in
R5541	T9234	T9233	amod	large,number
R5542	T9235	T9233	prep	of,number
R5543	T9236	T9237	amod	developmental,events
R5544	T9237	T9235	pobj	events,of
R5545	T9238	T9225	punct	.,suggest
R5546	T9240	T9241	nsubj	Many,occur
R5547	T9242	T9240	prep	of,Many
R5548	T9243	T9244	det	these,events
R5549	T9244	T9242	pobj	events,of
R5550	T9245	T9241	advmod	early,occur
R5551	T9246	T9241	prep	in,occur
R5552	T9247	T9246	pobj	embryogenesis,in
R5553	T9248	T9241	punct	", ",occur
R5554	T9249	T9241	cc	and,occur
R5555	T9250	T9251	amod	complete,inactivation
R5556	T9251	T9252	nsubj	inactivation,causes
R5557	T9252	T9241	conj	causes,occur
R5558	T9253	T9251	prep	of,inactivation
R5559	T9254	T9255	compound	BMP,receptors
R5560	T9255	T9253	pobj	receptors,of
R5561	T9256	T9252	dobj	death,causes
R5562	T9257	T9252	prep	by,causes
R5563	T9258	T9257	pobj	E9.5,by
R5564	T9259	T9260	punct	(,Mishina
R5565	T9260	T9252	meta	Mishina,causes
R5566	T9261	T9260	nmod	et,Mishina
R5567	T9262	T9260	nmod	al.,Mishina
R5568	T9263	T9260	nummod	1995,Mishina
R5569	T9264	T9260	punct	),Mishina
R5570	T9265	T9252	punct	.,causes
R5571	T9267	T9268	det	The,system
R5572	T9268	T9273	nsubj	system,bypasses
R5573	T9269	T9270	compound	Gdf5,Cre
R5574	T9270	T9268	compound	Cre,system
R5575	T9271	T9270	punct	-,Cre
R5576	T9272	T9268	compound	recombination,system
R5577	T9274	T9275	det	the,lethality
R5578	T9275	T9273	dobj	lethality,bypasses
R5579	T9276	T9275	amod	early,lethality
R5580	T9277	T9275	amod	embryonic,lethality
R5581	T9278	T9275	prep	of,lethality
R5582	T9279	T9280	compound	Bmpr1a,mutations
R5583	T9280	T9278	pobj	mutations,of
R5584	T9281	T9273	punct	", ",bypasses
R5585	T9282	T9273	cc	and,bypasses
R5586	T9283	T9273	conj	provides,bypasses
R5587	T9284	T9285	amod	important,information
R5588	T9285	T9283	dobj	information,provides
R5589	T9286	T9285	amod	new,information
R5590	T9287	T9285	prep	about,information
R5591	T9288	T9289	det	the,role
R5592	T9289	T9287	pobj	role,about
R5593	T9290	T9289	prep	of,role
R5594	T9291	T9292	det	this,receptor
R5595	T9292	T9290	pobj	receptor,of
R5596	T9293	T9289	prep	in,role
R5597	T9294	T9295	nmod	limb,development
R5598	T9295	T9293	pobj	development,in
R5599	T9296	T9294	cc	and,limb
R5600	T9297	T9294	conj	skeletal,limb
R5601	T9298	T9273	punct	.,bypasses
R5602	T9300	T9301	det	The,phenotypes
R5603	T9301	T9305	nsubj	phenotypes,include
R5604	T9302	T9301	nummod	three,phenotypes
R5605	T9303	T9301	amod	major,phenotypes
R5606	T9304	T9301	compound	limb,phenotypes
R5607	T9306	T9301	acl	revealed,phenotypes
R5608	T9307	T9306	agent	by,revealed
R5609	T9308	T9307	pcomp	eliminating,by
R5610	T9309	T9308	dobj	Bmpr1a,eliminating
R5611	T9310	T9308	prep	with,eliminating
R5612	T9311	T9312	npadvmod	Gdf5,driven
R5613	T9312	T9314	amod	driven,Cre
R5614	T9313	T9312	punct	-,driven
R5615	T9314	T9310	pobj	Cre,with
R5616	T9315	T9305	dobj	webbing,include
R5617	T9316	T9315	prep	between,webbing
R5618	T9317	T9316	pobj	digits,between
R5619	T9318	T9315	punct	", ",webbing
R5620	T9319	T9315	conj	lack,webbing
R5621	T9320	T9319	prep	of,lack
R5622	T9321	T9322	compound	joint,formation
R5623	T9322	T9320	pobj	formation,of
R5624	T9323	T9319	prep	at,lack
R5625	T9324	T9325	amod	specific,locations
R5626	T9325	T9323	pobj	locations,at
R5627	T9326	T9325	prep	in,locations
R5628	T9327	T9328	det	the,ankle
R5629	T9328	T9326	pobj	ankle,in
R5630	T9329	T9319	punct	", ",lack
R5631	T9330	T9319	cc	and,lack
R5632	T9331	T9319	conj	failure,lack
R5633	T9332	T9333	aux	to,maintain
R5634	T9333	T9331	acl	maintain,failure
R5635	T9334	T9335	amod	articular,cartilage
R5636	T9335	T9333	dobj	cartilage,maintain
R5637	T9336	T9333	prep	after,maintain
R5638	T9337	T9336	pobj	birth,after
R5639	T9338	T9333	punct	", ",maintain
R5640	T9339	T9333	advcl	resulting,maintain
R5641	T9340	T9339	prep	in,resulting
R5642	T9341	T9342	amod	severe,arthritis
R5643	T9342	T9340	pobj	arthritis,in
R5644	T9343	T9305	punct	.,include
R5645	T9345	T9346	amod	Previous,studies
R5646	T9346	T9347	nsubj	studies,shown
R5647	T9348	T9347	aux	have,shown
R5648	T9349	T9350	mark	that,alters
R5649	T9350	T9347	ccomp	alters,shown
R5650	T9351	T9350	nsubj	manipulation,alters
R5651	T9352	T9351	prep	of,manipulation
R5652	T9353	T9354	compound	BMP,signaling
R5653	T9354	T9352	pobj	signaling,of
R5654	T9355	T9356	amod	interdigital,apoptosis
R5655	T9356	T9350	dobj	apoptosis,alters
R5656	T9357	T9350	prep	during,alters
R5657	T9358	T9357	pobj	development,during
R5658	T9359	T9358	prep	of,development
R5659	T9360	T9361	det	the,limb
R5660	T9361	T9359	pobj	limb,of
R5661	T9362	T9347	punct	", ",shown
R5662	T9363	T9347	cc	but,shown
R5663	T9364	T9365	det	no,experiment
R5664	T9365	T9366	nsubj	experiment,identified
R5665	T9366	T9347	conj	identified,shown
R5666	T9367	T9366	aux	has,identified
R5667	T9368	T9369	det	a,member
R5668	T9369	T9366	dobj	member,identified
R5669	T9370	T9369	amod	specific,member
R5670	T9371	T9369	prep	of,member
R5671	T9372	T9373	det	the,pathway
R5672	T9373	T9371	pobj	pathway,of
R5673	T9374	T9375	compound	BMP,signaling
R5674	T9375	T9373	compound	signaling,pathway
R5675	T9376	T9377	dep	that,required
R5676	T9377	T9369	relcl	required,member
R5677	T9378	T9377	auxpass	is,required
R5678	T9379	T9377	prep	for,required
R5679	T9380	T9381	det	this,process
R5680	T9381	T9379	pobj	process,for
R5681	T9382	T9383	punct	(,Yokouchi
R5682	T9383	T9366	meta	Yokouchi,identified
R5683	T9384	T9383	nmod	et,Yokouchi
R5684	T9385	T9383	nmod	al.,Yokouchi
R5685	T9386	T9383	nummod	1996,Yokouchi
R5686	T9387	T9383	punct	;,Yokouchi
R5687	T9388	T9383	conj	Zou,Yokouchi
R5688	T9389	T9388	cc	and,Zou
R5689	T9390	T9388	conj	Niswander,Zou
R5690	T9391	T9390	nummod	1996,Niswander
R5691	T9392	T9390	punct	;,Niswander
R5692	T9393	T9390	conj	Zou,Niswander
R5693	T9394	T9393	nmod	et,Zou
R5694	T9395	T9393	nmod	al.,Zou
R5695	T9396	T9393	nummod	1997,Zou
R5696	T9397	T9393	punct	;,Zou
R5697	T9398	T9393	conj	Guha,Zou
R5698	T9399	T9398	nmod	et,Guha
R5699	T9400	T9398	nmod	al.,Guha
R5700	T9401	T9398	nummod	2002,Guha
R5701	T9402	T9398	punct	),Guha
R5702	T9403	T9366	punct	.,identified
R5703	T9405	T9406	poss	Our,data
R5704	T9406	T9413	nsubj	data,confirm
R5705	T9407	T9406	amod	new,data
R5706	T9408	T9406	nmod	loss,data
R5707	T9409	T9408	punct	-,loss
R5708	T9410	T9408	prep	of,loss
R5709	T9411	T9410	punct	-,of
R5710	T9412	T9410	pobj	function,of
R5711	T9414	T9415	mark	that,required
R5712	T9415	T9413	ccomp	required,confirm
R5713	T9416	T9417	compound	BMP,signaling
R5714	T9417	T9415	nsubjpass	signaling,required
R5715	T9418	T9415	auxpass	is,required
R5716	T9419	T9415	prep	for,required
R5717	T9420	T9421	amod	interdigital,apoptosis
R5718	T9421	T9419	pobj	apoptosis,for
R5719	T9422	T9415	cc	and,required
R5720	T9423	T9415	conj	suggests,required
R5721	T9424	T9425	mark	that,is
R5722	T9425	T9423	ccomp	is,suggests
R5723	T9426	T9425	nsubj	Bmpr1a,is
R5724	T9427	T9428	det	a,component
R5725	T9428	T9425	attr	component,is
R5726	T9429	T9428	amod	critical,component
R5727	T9430	T9428	prep	for,component
R5728	T9431	T9430	pcomp	mediating,for
R5729	T9432	T9433	det	this,signal
R5730	T9433	T9431	dobj	signal,mediating
R5731	T9434	T9413	punct	.,confirm
R5732	T9436	T9437	prep	At,leads
R5733	T9438	T9439	det	some,sites
R5734	T9439	T9436	pobj	sites,At
R5735	T9440	T9437	punct	", ",leads
R5736	T9441	T9437	nsubj	loss,leads
R5737	T9442	T9441	prep	of,loss
R5738	T9443	T9444	compound	Bmpr1a,function
R5739	T9444	T9442	pobj	function,of
R5740	T9445	T9437	prep	to,leads
R5741	T9446	T9447	det	a,defect
R5742	T9447	T9445	pobj	defect,to
R5743	T9448	T9447	prep	in,defect
R5744	T9449	T9450	det	the,stages
R5745	T9450	T9448	pobj	stages,in
R5746	T9451	T9450	amod	early,stages
R5747	T9452	T9450	prep	of,stages
R5748	T9453	T9454	compound	joint,formation
R5749	T9454	T9452	pobj	formation,of
R5750	T9455	T9437	punct	", ",leads
R5751	T9456	T9437	advcl	resulting,leads
R5752	T9457	T9456	prep	in,resulting
R5753	T9458	T9459	det	a,failure
R5754	T9459	T9457	pobj	failure,in
R5755	T9460	T9459	amod	complete,failure
R5756	T9461	T9462	aux	to,form
R5757	T9462	T9459	acl	form,failure
R5758	T9463	T9464	det	a,joint
R5759	T9464	T9462	dobj	joint,form
R5760	T9465	T9459	cc	and,failure
R5761	T9466	T9459	conj	fusion,failure
R5762	T9467	T9466	prep	of,fusion
R5763	T9468	T9467	pobj	bones,of
R5764	T9469	T9466	prep	in,fusion
R5765	T9470	T9471	det	the,ankle
R5766	T9471	T9469	pobj	ankle,in
R5767	T9472	T9437	punct	.,leads
R5768	T9474	T9475	nsubj	Mutations,produce
R5769	T9476	T9474	prep	in,Mutations
R5770	T9477	T9478	nummod	two,ligands
R5771	T9478	T9476	pobj	ligands,in
R5772	T9479	T9478	amod	different,ligands
R5773	T9480	T9478	prep	in,ligands
R5774	T9481	T9482	det	the,family
R5775	T9482	T9480	pobj	family,in
R5776	T9483	T9482	compound	BMP,family
R5777	T9484	T9478	punct	", ",ligands
R5778	T9485	T9478	appos	Gdf5,ligands
R5779	T9486	T9485	cc	and,Gdf5
R5780	T9487	T9485	conj	Gdf6,Gdf5
R5781	T9488	T9478	punct	", ",ligands
R5782	T9489	T9490	det	the,receptor
R5783	T9490	T9478	appos	receptor,ligands
R5784	T9491	T9490	compound	Bmpr1b,receptor
R5785	T9492	T9476	punct	", ",in
R5786	T9493	T9476	cc	and,in
R5787	T9494	T9476	conj	in,in
R5788	T9495	T9496	det	the,locus
R5789	T9496	T9494	pobj	locus,in
R5790	T9497	T9496	amod	human,locus
R5791	T9498	T9496	compound	Noggin,locus
R5792	T9499	T9500	punct	(,Storm
R5793	T9500	T9474	meta	Storm,Mutations
R5794	T9501	T9500	cc	and,Storm
R5795	T9502	T9500	conj	Kingsley,Storm
R5796	T9503	T9502	nummod	1996,Kingsley
R5797	T9504	T9502	punct	;,Kingsley
R5798	T9505	T9502	conj	Gong,Kingsley
R5799	T9506	T9505	nmod	et,Gong
R5800	T9507	T9505	nmod	al.,Gong
R5801	T9508	T9505	nummod	1999,Gong
R5802	T9509	T9505	punct	;,Gong
R5803	T9510	T9505	conj	Baur,Gong
R5804	T9511	T9510	nmod	et,Baur
R5805	T9512	T9510	nmod	al.,Baur
R5806	T9513	T9510	nummod	2000,Baur
R5807	T9514	T9510	punct	;,Baur
R5808	T9515	T9510	conj	Yi,Baur
R5809	T9516	T9515	nmod	et,Yi
R5810	T9517	T9515	nmod	al.,Yi
R5811	T9518	T9515	nummod	2000,Yi
R5812	T9519	T9515	punct	;,Yi
R5813	T9520	T9515	conj	Settle,Yi
R5814	T9521	T9520	nmod	et,Settle
R5815	T9522	T9520	nmod	al.,Settle
R5816	T9523	T9520	nummod	2003,Settle
R5817	T9524	T9520	punct	),Settle
R5818	T9525	T9475	advmod	also,produce
R5819	T9526	T9475	dobj	defects,produce
R5820	T9527	T9526	prep	in,defects
R5821	T9528	T9529	compound	joint,formation
R5822	T9529	T9527	pobj	formation,in
R5823	T9530	T9475	prep	at,produce
R5824	T9531	T9532	amod	specific,locations
R5825	T9532	T9530	pobj	locations,at
R5826	T9533	T9532	prep	in,locations
R5827	T9534	T9535	det	the,limbs
R5828	T9535	T9533	pobj	limbs,in
R5829	T9536	T9475	punct	.,produce
R5830	T9538	T9539	det	The,defects
R5831	T9539	T9541	nsubj	defects,provide
R5832	T9540	T9539	compound	joint,defects
R5833	T9542	T9539	acl	associated,defects
R5834	T9543	T9542	prep	with,associated
R5835	T9544	T9545	amod	multiple,components
R5836	T9545	T9543	pobj	components,with
R5837	T9546	T9545	prep	of,components
R5838	T9547	T9548	det	the,pathway
R5839	T9548	T9546	pobj	pathway,of
R5840	T9549	T9548	compound	BMP,pathway
R5841	T9550	T9551	amod	strong,evidence
R5842	T9551	T9541	dobj	evidence,provide
R5843	T9552	T9553	mark	that,required
R5844	T9553	T9551	acl	required,evidence
R5845	T9554	T9555	compound	BMP,signaling
R5846	T9555	T9553	nsubjpass	signaling,required
R5847	T9556	T9553	auxpass	is,required
R5848	T9557	T9553	prep	for,required
R5849	T9558	T9559	amod	early,stages
R5850	T9559	T9557	pobj	stages,for
R5851	T9560	T9559	prep	of,stages
R5852	T9561	T9562	compound	joint,formation
R5853	T9562	T9560	pobj	formation,of
R5854	T9563	T9553	prep	at,required
R5855	T9564	T9565	det	some,locations
R5856	T9565	T9563	pobj	locations,at
R5857	T9566	T9565	amod	anatomical,locations
R5858	T9567	T9541	punct	.,provide
R5859	T9569	T9570	amod	Most,joints
R5860	T9570	T9571	nsubj	joints,form
R5861	T9572	T9571	advmod	still,form
R5862	T9573	T9571	advmod	normally,form
R5863	T9574	T9575	advmod	when,knocked
R5864	T9575	T9571	advcl	knocked,form
R5865	T9576	T9575	nsubjpass	Bmpr1a,knocked
R5866	T9577	T9575	auxpass	is,knocked
R5867	T9578	T9575	prt	out,knocked
R5868	T9579	T9575	prep	in,knocked
R5869	T9580	T9581	compound	Gdf5,domains
R5870	T9581	T9579	pobj	domains,in
R5871	T9582	T9581	compound	expression,domains
R5872	T9583	T9571	punct	.,form
R5873	T9585	T9586	det	The,lack
R5874	T9586	T9587	nsubj	lack,be
R5875	T9588	T9586	prep	of,lack
R5876	T9589	T9590	compound	joint,fusions
R5877	T9590	T9588	pobj	fusions,of
R5878	T9591	T9586	prep	outside,lack
R5879	T9592	T9593	det	the,region
R5880	T9593	T9591	pobj	region,outside
R5881	T9594	T9593	compound	ankle,region
R5882	T9595	T9587	aux	could,be
R5883	T9596	T9587	prep	due,be
R5884	T9597	T9596	prep	to,due
R5885	T9598	T9597	pobj	differences,to
R5886	T9599	T9598	prep	in,differences
R5887	T9600	T9599	pobj	requirement,in
R5888	T9601	T9600	prep	for,requirement
R5889	T9602	T9603	compound	BMP,signaling
R5890	T9603	T9601	pobj	signaling,for
R5891	T9604	T9598	prep	in,differences
R5892	T9605	T9606	amod	different,joints
R5893	T9606	T9604	pobj	joints,in
R5894	T9607	T9597	punct	", ",to
R5895	T9608	T9597	conj	to,to
R5896	T9609	T9610	amod	compensating,expression
R5897	T9610	T9608	pobj	expression,to
R5898	T9611	T9610	prep	of,expression
R5899	T9612	T9613	amod	other,receptors
R5900	T9613	T9611	pobj	receptors,of
R5901	T9614	T9613	compound	BMP,receptors
R5902	T9615	T9613	prep	outside,receptors
R5903	T9616	T9617	det	the,ankles
R5904	T9617	T9615	pobj	ankles,outside
R5905	T9618	T9608	punct	", ",to
R5906	T9619	T9608	cc	or,to
R5907	T9620	T9608	conj	to,to
R5908	T9621	T9620	pobj	differences,to
R5909	T9622	T9621	prep	in,differences
R5910	T9623	T9624	det	the,timing
R5911	T9624	T9622	pobj	timing,in
R5912	T9625	T9624	amod	detailed,timing
R5913	T9626	T9624	prep	of,timing
R5914	T9627	T9628	compound	Gdf5,Cre
R5915	T9628	T9630	npadvmod	Cre,stimulated
R5916	T9629	T9628	punct	-,Cre
R5917	T9630	T9631	amod	stimulated,inactivation
R5918	T9631	T9626	pobj	inactivation,of
R5919	T9632	T9631	compound	gene,inactivation
R5920	T9633	T9631	prep	in,inactivation
R5921	T9634	T9633	pobj	ankles,in
R5922	T9635	T9634	cc	and,ankles
R5923	T9636	T9637	amod	other,regions
R5924	T9637	T9634	conj	regions,ankles
R5925	T9638	T9637	compound	joint,regions
R5926	T9639	T9587	punct	.,be
R5927	T9641	T9642	nsubj	Comparison,suggests
R5928	T9643	T9641	prep	of,Comparison
R5929	T9644	T9645	det	the,expression
R5930	T9645	T9643	pobj	expression,of
R5931	T9646	T9645	prep	of,expression
R5932	T9647	T9648	det	the,marker
R5933	T9648	T9646	pobj	marker,of
R5934	T9649	T9648	compound	HPLAP,marker
R5935	T9650	T9648	punct	(,marker
R5936	T9651	T9648	acl	driven,marker
R5937	T9652	T9651	advmod	directly,driven
R5938	T9653	T9651	agent	by,driven
R5939	T9654	T9655	compound	Gdf5,elements
R5940	T9655	T9653	pobj	elements,by
R5941	T9656	T9655	compound	control,elements
R5942	T9657	T9648	punct	),marker
R5943	T9658	T9648	cc	and,marker
R5944	T9659	T9660	det	the,marker
R5945	T9660	T9648	conj	marker,marker
R5946	T9661	T9662	compound	R26R,LACZ
R5947	T9662	T9660	compound	LACZ,marker
R5948	T9663	T9660	punct	(,marker
R5949	T9664	T9660	acl	expressed,marker
R5950	T9665	T9664	advcl	following,expressed
R5951	T9666	T9667	compound	Gdf5,Cre
R5952	T9667	T9669	compound	Cre,recombination
R5953	T9668	T9667	punct	-,Cre
R5954	T9669	T9665	dobj	recombination,following
R5955	T9670	T9660	punct	),marker
R5956	T9671	T9672	mark	that,delayed
R5957	T9672	T9642	ccomp	delayed,suggests
R5958	T9673	T9674	npadvmod	recombination,stimulated
R5959	T9674	T9676	amod	stimulated,changes
R5960	T9675	T9674	punct	-,stimulated
R5961	T9676	T9672	nsubjpass	changes,delayed
R5962	T9677	T9676	prep	in,changes
R5963	T9678	T9679	compound	gene,expression
R5964	T9679	T9677	pobj	expression,in
R5965	T9680	T9672	aux	may,delayed
R5966	T9681	T9672	auxpass	be,delayed
R5967	T9682	T9672	prep	for,delayed
R5968	T9683	T9684	det	a,d
R5969	T9684	T9682	pobj	d,for
R5970	T9685	T9686	quantmod	0.5,1
R5971	T9686	T9684	nummod	1,d
R5972	T9687	T9686	punct	–,1
R5973	T9688	T9672	prep	in,delayed
R5974	T9689	T9690	det	the,region
R5975	T9690	T9688	pobj	region,in
R5976	T9691	T9690	compound	digit,region
R5977	T9692	T9693	punct	(,see
R5978	T9693	T9642	parataxis	see,suggests
R5979	T9694	T9693	dobj	Figure,see
R5980	T9695	T9694	nummod	1C,Figure
R5981	T9696	T9693	punct	),see
R5982	T9697	T9642	punct	.,suggests
R5983	T9699	T9700	prep	In,persist
R5984	T9701	T9699	pobj	addition,In
R5985	T9702	T9700	punct	", ",persist
R5986	T9703	T9700	nsubj	levels,persist
R5987	T9704	T9703	prep	of,levels
R5988	T9705	T9706	compound	Bmpr1a,mRNA
R5989	T9706	T9704	pobj	mRNA,of
R5990	T9707	T9706	cc	and,mRNA
R5991	T9708	T9706	conj	protein,mRNA
R5992	T9709	T9700	aux	may,persist
R5993	T9710	T9700	prep	for,persist
R5994	T9711	T9712	det	some,time
R5995	T9712	T9710	pobj	time,for
R5996	T9713	T9700	prep	following,persist
R5997	T9714	T9715	compound	Gdf5,Cre
R5998	T9715	T9717	npadvmod	Cre,stimulated
R5999	T9716	T9715	punct	-,Cre
R6000	T9717	T9718	amod	stimulated,recombination
R6001	T9718	T9713	pobj	recombination,following
R6002	T9719	T9700	punct	", ",persist
R6003	T9720	T9700	advcl	making,persist
R6004	T9721	T9722	nsubj	it,possible
R6005	T9722	T9720	ccomp	possible,making
R6006	T9723	T9724	aux	to,bypass
R6007	T9724	T9722	advcl	bypass,possible
R6008	T9725	T9726	det	an,requirement
R6009	T9726	T9724	dobj	requirement,bypass
R6010	T9727	T9726	amod	early,requirement
R6011	T9728	T9726	prep	for,requirement
R6012	T9729	T9728	pobj	Bmpr1a,for
R6013	T9730	T9726	prep	in,requirement
R6014	T9731	T9732	compound	joint,formation
R6015	T9732	T9730	pobj	formation,in
R6016	T9733	T9732	prep	at,formation
R6017	T9734	T9735	det	some,locations
R6018	T9735	T9733	pobj	locations,at
R6019	T9736	T9700	punct	.,persist
R6020	T9738	T9739	prep	Following,result
R6021	T9740	T9741	det	the,decay
R6022	T9741	T9738	pobj	decay,Following
R6023	T9742	T9741	prep	of,decay
R6024	T9743	T9744	compound	Bmpr1a,mRNA
R6025	T9744	T9742	pobj	mRNA,of
R6026	T9745	T9744	cc	and,mRNA
R6027	T9746	T9744	conj	protein,mRNA
R6028	T9747	T9739	punct	", ",result
R6029	T9748	T9749	det	the,strategy
R6030	T9749	T9739	nsubj	strategy,result
R6031	T9750	T9751	compound	Gdf5,Cre
R6032	T9751	T9749	compound	Cre,strategy
R6033	T9752	T9751	punct	-,Cre
R6034	T9753	T9739	aux	should,result
R6035	T9754	T9739	prep	in,result
R6036	T9755	T9756	amod	permanent,inactivation
R6037	T9756	T9754	pobj	inactivation,in
R6038	T9757	T9756	prep	of,inactivation
R6039	T9758	T9759	compound	Bmpr1a,function
R6040	T9759	T9757	pobj	function,of
R6041	T9760	T9756	prep	in,inactivation
R6042	T9761	T9762	amod	recombined,cells
R6043	T9762	T9760	pobj	cells,in
R6044	T9763	T9739	punct	.,result
R6045	T9765	T9766	det	This,system
R6046	T9766	T9767	nsubj	system,provides
R6047	T9768	T9767	advmod	thus,provides
R6048	T9769	T9767	dobj	one,provides
R6049	T9770	T9769	prep	of,one
R6050	T9771	T9772	det	the,tests
R6051	T9772	T9770	pobj	tests,of
R6052	T9773	T9772	amod	first,tests
R6053	T9774	T9772	amod	strong,tests
R6054	T9775	T9772	amod	genetic,tests
R6055	T9776	T9772	prep	of,tests
R6056	T9777	T9778	compound	Bmpr1a,function
R6057	T9778	T9776	pobj	function,of
R6058	T9779	T9767	prep	at,provides
R6059	T9780	T9781	amod	later,stages
R6060	T9781	T9779	pobj	stages,at
R6061	T9782	T9781	prep	of,stages
R6062	T9783	T9784	compound	joint,development
R6063	T9784	T9782	pobj	development,of
R6064	T9785	T9767	punct	.,provides
R6065	T9787	T9788	prep	Despite,are
R6066	T9789	T9790	det	the,appearance
R6067	T9790	T9787	pobj	appearance,Despite
R6068	T9791	T9790	amod	normal,appearance
R6069	T9792	T9790	prep	of,appearance
R6070	T9793	T9794	amod	articular,regions
R6071	T9794	T9792	pobj	regions,of
R6072	T9795	T9794	cc	and,regions
R6073	T9796	T9797	compound	gene,expression
R6074	T9797	T9794	conj	expression,regions
R6075	T9798	T9799	advmod	immediately,after
R6076	T9799	T9790	prep	after,appearance
R6077	T9800	T9799	pobj	birth,after
R6078	T9801	T9788	punct	", ",are
R6079	T9802	T9803	npadvmod	Bmpr1a,deficient
R6080	T9803	T9805	amod	deficient,animals
R6081	T9804	T9803	punct	-,deficient
R6082	T9805	T9788	nsubj	animals,are
R6083	T9806	T9788	acomp	unable,are
R6084	T9807	T9808	aux	to,maintain
R6085	T9808	T9806	xcomp	maintain,unable
R6086	T9809	T9810	det	the,state
R6087	T9810	T9808	dobj	state,maintain
R6088	T9811	T9810	amod	normal,state
R6089	T9812	T9810	amod	differentiated,state
R6090	T9813	T9810	prep	of,state
R6091	T9814	T9815	amod	articular,cartilage
R6092	T9815	T9813	pobj	cartilage,of
R6093	T9816	T9817	mark	as,continue
R6094	T9817	T9808	advcl	continue,maintain
R6095	T9818	T9817	nsubj	they,continue
R6096	T9819	T9820	aux	to,develop
R6097	T9820	T9817	xcomp	develop,continue
R6098	T9821	T9820	cc	and,develop
R6099	T9822	T9820	conj	age,develop
R6100	T9823	T9788	punct	.,are
R6101	T9825	T9826	det	These,results
R6102	T9826	T9827	nsubj	results,suggest
R6103	T9828	T9829	mark	that,is
R6104	T9829	T9827	ccomp	is,suggest
R6105	T9830	T9831	compound	BMP,receptor
R6106	T9831	T9832	compound	receptor,signaling
R6107	T9832	T9829	nsubj	signaling,is
R6108	T9833	T9829	acomp	essential,is
R6109	T9834	T9833	prep	for,essential
R6110	T9835	T9836	amod	continued,health
R6111	T9836	T9834	pobj	health,for
R6112	T9837	T9836	cc	and,health
R6113	T9838	T9836	conj	integrity,health
R6114	T9839	T9838	prep	of,integrity
R6115	T9840	T9841	amod	articular,cartilage
R6116	T9841	T9839	pobj	cartilage,of
R6117	T9842	T9829	prep	in,is
R6118	T9843	T9844	det	the,period
R6119	T9844	T9842	pobj	period,in
R6120	T9845	T9844	amod	postnatal,period
R6121	T9846	T9827	punct	.,suggest
R6122	T9848	T9849	amod	Articular,cartilage
R6123	T9849	T9850	nsubj	cartilage,is
R6124	T9851	T9852	det	a,component
R6125	T9852	T9850	attr	component,is
R6126	T9853	T9852	amod	key,component
R6127	T9854	T9852	prep	of,component
R6128	T9855	T9856	amod	synovial,joints
R6129	T9856	T9854	pobj	joints,of
R6130	T9857	T9850	cc	and,is
R6131	T9858	T9850	conj	is,is
R6132	T9859	T9858	attr	one,is
R6133	T9860	T9859	prep	of,one
R6134	T9861	T9862	det	the,regions
R6135	T9862	T9860	pobj	regions,of
R6136	T9863	T9862	amod	few,regions
R6137	T9864	T9862	prep	in,regions
R6138	T9865	T9866	det	the,skeleton
R6139	T9866	T9864	pobj	skeleton,in
R6140	T9867	T9868	advmod	where,maintained
R6141	T9868	T9862	relcl	maintained,regions
R6142	T9869	T9868	nsubjpass	cartilage,maintained
R6143	T9870	T9868	auxpass	is,maintained
R6144	T9871	T9868	prep	into,maintained
R6145	T9872	T9871	pobj	adulthood,into
R6146	T9873	T9850	punct	.,is
R6147	T9875	T9876	prep	Despite,known
R6148	T9877	T9878	det	the,importance
R6149	T9878	T9875	pobj	importance,Despite
R6150	T9879	T9878	prep	of,importance
R6151	T9880	T9881	amod	articular,cartilage
R6152	T9881	T9879	pobj	cartilage,of
R6153	T9882	T9878	prep	in,importance
R6154	T9883	T9884	compound	joint,health
R6155	T9884	T9882	pobj	health,in
R6156	T9885	T9884	cc	and,health
R6157	T9886	T9884	conj	mobility,health
R6158	T9887	T9876	punct	", ",known
R6159	T9888	T9876	nsubjpass	little,known
R6160	T9889	T9876	auxpass	is,known
R6161	T9890	T9876	prep	about,known
R6162	T9891	T9892	det	the,factors
R6163	T9892	T9890	pobj	factors,about
R6164	T9893	T9894	dep	that,create
R6165	T9894	T9892	relcl	create,factors
R6166	T9895	T9894	cc	and,create
R6167	T9896	T9894	conj	maintain,create
R6168	T9897	T9896	dobj	it,maintain
R6169	T9898	T9896	prep	in,maintain
R6170	T9899	T9900	amod	thin,layers
R6171	T9900	T9898	pobj	layers,in
R6172	T9901	T9900	prep	at,layers
R6173	T9902	T9903	det	the,ends
R6174	T9903	T9901	pobj	ends,at
R6175	T9904	T9903	prep	of,ends
R6176	T9905	T9906	amod	long,bones
R6177	T9906	T9904	pobj	bones,of
R6178	T9907	T9876	punct	.,known
R6179	T9909	T9910	prep	In,retains
R6180	T9911	T9912	poss	our,experiments
R6181	T9912	T9909	pobj	experiments,In
R6182	T9913	T9910	punct	", ",retains
R6183	T9914	T9915	amod	articular,cartilage
R6184	T9915	T9916	npadvmod	cartilage,lacking
R6185	T9916	T9917	amod	lacking,Bmpr1a
R6186	T9917	T9910	nsubj	Bmpr1a,retains
R6187	T9918	T9919	det	some,characteristics
R6188	T9919	T9910	dobj	characteristics,retains
R6189	T9920	T9919	amod	normal,characteristics
R6190	T9921	T9910	punct	", ",retains
R6191	T9922	T9923	mark	in,maintains
R6192	T9923	T9910	advcl	maintains,retains
R6193	T9924	T9923	mark	that,maintains
R6194	T9925	T9923	nsubj	it,maintains
R6195	T9926	T9927	det	a,rate
R6196	T9927	T9923	dobj	rate,maintains
R6197	T9928	T9929	advmod	very,low
R6198	T9929	T9927	amod	low,rate
R6199	T9930	T9927	compound	proliferation,rate
R6200	T9931	T9923	punct	", ",maintains
R6201	T9932	T9933	aux	does,express
R6202	T9933	T9923	conj	express,maintains
R6203	T9934	T9933	neg	not,express
R6204	T9935	T9933	dobj	Col1a1,express
R6205	T9936	T9933	punct	", ",express
R6206	T9937	T9933	cc	and,express
R6207	T9938	T9933	conj	continues,express
R6208	T9939	T9940	aux	to,express
R6209	T9940	T9938	xcomp	express,continues
R6210	T9941	T9940	dobj	SOX9,express
R6211	T9942	T9941	punct	", ",SOX9
R6212	T9943	T9944	det	a,factor
R6213	T9944	T9941	appos	factor,SOX9
R6214	T9945	T9944	amod	major,factor
R6215	T9946	T9944	compound	transcription,factor
R6216	T9947	T9944	acl	regulating,factor
R6217	T9948	T9947	dobj	expression,regulating
R6218	T9949	T9948	prep	of,expression
R6219	T9950	T9951	amod	structural,components
R6220	T9951	T9949	pobj	components,of
R6221	T9952	T9951	prep	of,components
R6222	T9953	T9954	compound	cartilage,matrix
R6223	T9954	T9952	pobj	matrix,of
R6224	T9955	T9910	punct	.,retains
R6225	T9957	T9958	advmod	However,fail
R6226	T9959	T9958	punct	", ",fail
R6227	T9960	T9958	nsubj	several,fail
R6228	T9961	T9960	prep	of,several
R6229	T9962	T9963	det	the,components
R6230	T9963	T9961	pobj	components,of
R6231	T9964	T9965	advmod	most,prominent
R6232	T9965	T9963	amod	prominent,components
R6233	T9966	T9963	amod	structural,components
R6234	T9967	T9963	prep	of,components
R6235	T9968	T9969	compound	cartilage,matrix
R6236	T9969	T9967	pobj	matrix,of
R6237	T9970	T9971	aux	to,maintained
R6238	T9971	T9958	xcomp	maintained,fail
R6239	T9972	T9971	auxpass	be,maintained
R6240	T9973	T9971	prep	in,maintained
R6241	T9974	T9975	compound	mutant,animals
R6242	T9975	T9973	pobj	animals,in
R6243	T9976	T9971	punct	", ",maintained
R6244	T9977	T9971	advcl	resulting,maintained
R6245	T9978	T9977	prep	in,resulting
R6246	T9979	T9980	amod	decreased,synthesis
R6247	T9980	T9978	pobj	synthesis,in
R6248	T9981	T9980	prep	of,synthesis
R6249	T9982	T9981	pobj	Col2a1,of
R6250	T9983	T9982	punct	", ",Col2a1
R6251	T9984	T9982	conj	Agg,Col2a1
R6252	T9985	T9984	punct	", ",Agg
R6253	T9986	T9984	cc	and,Agg
R6254	T9987	T9984	conj	proteoglycans,Agg
R6255	T9988	T9958	punct	.,fail
R6256	T9990	T9991	advmod	Therefore,appears
R6257	T9992	T9991	punct	", ",appears
R6258	T9993	T9991	nsubj	BMPR1A,appears
R6259	T9994	T9995	aux	to,maintain
R6260	T9995	T9991	xcomp	maintain,appears
R6261	T9996	T9997	amod	articular,cartilage
R6262	T9997	T9995	dobj	cartilage,maintain
R6263	T9998	T9999	advmod	primarily,through
R6264	T9999	T9995	prep	through,maintain
R6265	T10000	T9999	pcomp	inducing,through
R6266	T10001	T10000	dobj	expression,inducing
R6267	T10002	T10001	prep	of,expression
R6268	T10003	T10004	amod	key,components
R6269	T10004	T10002	pobj	components,of
R6270	T10005	T10004	compound	ECM,components
R6271	T10006	T9991	punct	.,appears
R6272	T10008	T10009	nsubj	It,is
R6273	T10010	T10009	acomp	interesting,is
R6274	T10011	T10012	mark	that,continues
R6275	T10012	T10009	ccomp	continues,is
R6276	T10013	T10014	det	the,factor
R6277	T10014	T10012	nsubj	factor,continues
R6278	T10015	T10016	compound	SOX9,transcription
R6279	T10016	T10014	compound	transcription,factor
R6280	T10017	T10018	aux	to,expressed
R6281	T10018	T10012	xcomp	expressed,continues
R6282	T10019	T10018	auxpass	be,expressed
R6283	T10020	T10018	prep	in,expressed
R6284	T10021	T10022	compound	mutant,cartilage
R6285	T10022	T10020	pobj	cartilage,in
R6286	T10023	T10018	prep	despite,expressed
R6287	T10024	T10023	pobj	loss,despite
R6288	T10025	T10024	prep	of,loss
R6289	T10026	T10025	pobj	Col2a1,of
R6290	T10027	T10026	punct	", ",Col2a1
R6291	T10028	T10029	det	a,target
R6292	T10029	T10026	appos	target,Col2a1
R6293	T10030	T10029	amod	direct,target
R6294	T10031	T10029	prep	of,target
R6295	T10032	T10033	det	this,factor
R6296	T10033	T10031	pobj	factor,of
R6297	T10034	T10033	compound	transcription,factor
R6298	T10035	T10036	punct	(,Bell
R6299	T10036	T10009	meta	Bell,is
R6300	T10037	T10036	nmod	et,Bell
R6301	T10038	T10036	nmod	al.,Bell
R6302	T10039	T10036	nummod	1997,Bell
R6303	T10040	T10036	punct	;,Bell
R6304	T10041	T10036	nmod	Lefebvre,Bell
R6305	T10042	T10036	nmod	et,Bell
R6306	T10043	T10036	nmod	al.,Bell
R6307	T10044	T10036	nummod	1997,Bell
R6308	T10045	T10036	punct	),Bell
R6309	T10046	T10009	punct	.,is
R6310	T10048	T10049	amod	Previous,studies
R6311	T10049	T10050	nsubj	studies,suggest
R6312	T10051	T10052	mark	that,modified
R6313	T10052	T10050	ccomp	modified,suggest
R6314	T10053	T10054	compound	SOX9,activity
R6315	T10054	T10052	nsubjpass	activity,modified
R6316	T10055	T10052	aux	can,modified
R6317	T10056	T10052	auxpass	be,modified
R6318	T10057	T10052	prep	by,modified
R6319	T10058	T10059	compound	protein,A
R6320	T10059	T10061	npadvmod	A,dependent
R6321	T10060	T10059	compound	kinase,A
R6322	T10061	T10066	amod	dependent,phosphorylation
R6323	T10062	T10059	punct	(,A
R6324	T10063	T10059	appos	PKA,A
R6325	T10064	T10059	punct	),A
R6326	T10065	T10061	punct	-,dependent
R6327	T10066	T10057	pobj	phosphorylation,by
R6328	T10067	T10066	compound	protein,phosphorylation
R6329	T10068	T10057	punct	", ",by
R6330	T10069	T10057	cc	or,by
R6331	T10070	T10057	conj	by,by
R6332	T10071	T10070	pobj	coexpression,by
R6333	T10072	T10071	prep	of,coexpression
R6334	T10073	T10074	nummod	two,proteins
R6335	T10074	T10072	pobj	proteins,of
R6336	T10075	T10074	amod	related,proteins
R6337	T10076	T10074	punct	", ",proteins
R6338	T10077	T10078	compound	L,SOX5
R6339	T10078	T10074	appos	SOX5,proteins
R6340	T10079	T10078	punct	-,SOX5
R6341	T10080	T10078	cc	and,SOX5
R6342	T10081	T10078	conj	SOX6,SOX5
R6343	T10082	T10083	punct	(,Lefebvre
R6344	T10083	T10050	meta	Lefebvre,suggest
R6345	T10084	T10083	nmod	et,Lefebvre
R6346	T10085	T10083	nmod	al.,Lefebvre
R6347	T10086	T10083	nummod	1998,Lefebvre
R6348	T10087	T10083	punct	;,Lefebvre
R6349	T10088	T10083	nmod	Huang,Lefebvre
R6350	T10089	T10083	nmod	et,Lefebvre
R6351	T10090	T10083	nmod	al.,Lefebvre
R6352	T10091	T10083	nummod	2000,Lefebvre
R6353	T10092	T10083	punct	),Lefebvre
R6354	T10093	T10050	punct	.,suggest
R6355	T10095	T10096	prep	In,reveals
R6356	T10097	T10095	pobj	addition,In
R6357	T10098	T10096	punct	", ",reveals
R6358	T10099	T10100	amod	close,examination
R6359	T10100	T10096	nsubj	examination,reveals
R6360	T10101	T10100	prep	of,examination
R6361	T10102	T10103	det	the,order
R6362	T10103	T10101	pobj	order,of
R6363	T10104	T10103	prep	of,order
R6364	T10105	T10104	pobj	genes,of
R6365	T10106	T10105	acl	induced,genes
R6366	T10107	T10106	prep	during,induced
R6367	T10108	T10109	compound	chicken,formation
R6368	T10109	T10107	pobj	formation,during
R6369	T10110	T10109	compound	digit,formation
R6370	T10111	T10112	mark	that,turns
R6371	T10112	T10096	ccomp	turns,reveals
R6372	T10113	T10112	nsubj	Sox9,turns
R6373	T10114	T10112	prt	on,turns
R6374	T10115	T10112	advmod	first,turns
R6375	T10116	T10112	punct	", ",turns
R6376	T10117	T10112	advcl	followed,turns
R6377	T10118	T10117	agent	by,followed
R6378	T10119	T10118	pobj	Bmpr1b,by
R6379	T10120	T10119	prep	with,Bmpr1b
R6380	T10121	T10122	compound	L,Sox5
R6381	T10122	T10120	pobj	Sox5,with
R6382	T10123	T10122	punct	-,Sox5
R6383	T10124	T10119	punct	", ",Bmpr1b
R6384	T10125	T10119	cc	and,Bmpr1b
R6385	T10126	T10127	advmod	then,Sox6
R6386	T10127	T10119	conj	Sox6,Bmpr1b
R6387	T10128	T10127	cc	and,Sox6
R6388	T10129	T10130	det	the,components
R6389	T10130	T10127	conj	components,Sox6
R6390	T10131	T10132	nmod	cartilage,matrix
R6391	T10132	T10130	nmod	matrix,components
R6392	T10133	T10130	amod	structural,components
R6393	T10134	T10130	appos	Col2a1,components
R6394	T10135	T10134	cc	and,Col2a1
R6395	T10136	T10134	conj	Agg,Col2a1
R6396	T10137	T10138	punct	(,Chimal
R6397	T10138	T10096	meta	Chimal,reveals
R6398	T10139	T10138	punct	-,Chimal
R6399	T10140	T10138	nmod	Monroy,Chimal
R6400	T10141	T10138	nmod	et,Chimal
R6401	T10142	T10138	nmod	al.,Chimal
R6402	T10143	T10138	nummod	2003,Chimal
R6403	T10144	T10138	punct	),Chimal
R6404	T10145	T10096	punct	.,reveals
R6405	T10147	T10148	det	These,results
R6406	T10148	T10149	nsubj	results,suggest
R6407	T10150	T10148	punct	", ",results
R6408	T10151	T10148	advmod	together,results
R6409	T10152	T10151	prep	with,together
R6410	T10153	T10154	det	the,pattern
R6411	T10154	T10152	pobj	pattern,with
R6412	T10155	T10154	amod	altered,pattern
R6413	T10156	T10154	prep	of,pattern
R6414	T10157	T10158	compound	gene,expression
R6415	T10158	T10156	pobj	expression,of
R6416	T10159	T10154	acl	seen,pattern
R6417	T10160	T10159	prep	in,seen
R6418	T10161	T10162	poss	our,mice
R6419	T10162	T10160	pobj	mice,in
R6420	T10163	T10164	npadvmod	Bmpr1a,deficient
R6421	T10164	T10162	amod	deficient,mice
R6422	T10165	T10164	punct	-,deficient
R6423	T10166	T10149	punct	", ",suggest
R6424	T10167	T10168	mark	that,act
R6425	T10168	T10149	ccomp	act,suggest
R6426	T10169	T10170	compound	BMPR1A,signaling
R6427	T10170	T10168	nsubj	signaling,act
R6428	T10171	T10168	aux	may,act
R6429	T10172	T10168	advmod	normally,act
R6430	T10173	T10174	aux	to,stimulate
R6431	T10174	T10168	xcomp	stimulate,act
R6432	T10175	T10174	dobj	SOX9,stimulate
R6433	T10176	T10174	prep	by,stimulate
R6434	T10177	T10178	amod	post-translational,modification
R6435	T10178	T10176	pobj	modification,by
R6436	T10179	T10178	compound	protein,modification
R6437	T10180	T10174	punct	", ",stimulate
R6438	T10181	T10174	cc	or,stimulate
R6439	T10182	T10183	aux	to,induce
R6440	T10183	T10174	conj	induce,stimulate
R6441	T10184	T10185	compound	L,Sox5
R6442	T10185	T10183	dobj	Sox5,induce
R6443	T10186	T10185	punct	-,Sox5
R6444	T10187	T10185	cc	or,Sox5
R6445	T10188	T10185	conj	Sox6,Sox5
R6446	T10189	T10183	prep	in,induce
R6447	T10190	T10189	pobj	cartilage,in
R6448	T10191	T10192	aux	to,maintain
R6449	T10192	T10183	advcl	maintain,induce
R6450	T10193	T10192	dobj	expression,maintain
R6451	T10194	T10193	prep	of,expression
R6452	T10195	T10196	compound	ECM,components
R6453	T10196	T10194	pobj	components,of
R6454	T10197	T10149	punct	.,suggest
R6455	T10199	T10200	det	These,models
R6456	T10200	T10201	nsubj	models,are
R6457	T10202	T10201	acomp	consistent,are
R6458	T10203	T10202	prep	with,consistent
R6459	T10204	T10205	det	the,ability
R6460	T10205	T10203	pobj	ability,with
R6461	T10206	T10205	prep	of,ability
R6462	T10207	T10206	pobj	BMP2,of
R6463	T10208	T10209	aux	to,increase
R6464	T10209	T10205	acl	increase,ability
R6465	T10210	T10209	preconj	both,increase
R6466	T10211	T10212	compound	PKA,activity
R6467	T10212	T10209	dobj	activity,increase
R6468	T10213	T10209	cc	and,increase
R6469	T10214	T10209	conj	induce,increase
R6470	T10215	T10214	dobj	expression,induce
R6471	T10216	T10215	prep	of,expression
R6472	T10217	T10216	pobj	Sox6,of
R6473	T10218	T10214	prep	in,induce
R6474	T10219	T10220	compound	tissue,cells
R6475	T10220	T10218	pobj	cells,in
R6476	T10221	T10220	compound	culture,cells
R6477	T10222	T10223	punct	(,Lee
R6478	T10223	T10201	meta	Lee,are
R6479	T10224	T10223	cc	and,Lee
R6480	T10225	T10223	conj	Chuong,Lee
R6481	T10226	T10225	nummod	1997,Chuong
R6482	T10227	T10225	punct	;,Chuong
R6483	T10228	T10225	conj	Fernandez,Chuong
R6484	T10229	T10228	punct	-,Fernandez
R6485	T10230	T10228	nmod	Lloris,Fernandez
R6486	T10231	T10228	nmod	et,Fernandez
R6487	T10232	T10228	nmod	al.,Fernandez
R6488	T10233	T10228	nummod	2003,Fernandez
R6489	T10234	T10228	punct	),Fernandez
R6490	T10235	T10201	punct	.,are
R6491	T10237	T10238	mark	Although,tried
R6492	T10238	T10241	advcl	tried,been
R6493	T10239	T10238	nsubj	we,tried
R6494	T10240	T10238	aux	have,tried
R6495	T10242	T10243	aux	to,monitor
R6496	T10243	T10238	xcomp	monitor,tried
R6497	T10244	T10245	det	the,expression
R6498	T10245	T10243	dobj	expression,monitor
R6499	T10246	T10245	prep	of,expression
R6500	T10247	T10248	compound	L,Sox5
R6501	T10248	T10246	pobj	Sox5,of
R6502	T10249	T10248	punct	-,Sox5
R6503	T10250	T10248	cc	or,Sox5
R6504	T10251	T10248	conj	Sox6,Sox5
R6505	T10252	T10243	prep	in,monitor
R6506	T10253	T10254	amod	postnatal,cartilage
R6507	T10254	T10252	pobj	cartilage,in
R6508	T10255	T10254	amod	articular,cartilage
R6509	T10256	T10243	punct	", ",monitor
R6510	T10257	T10243	cc	and,monitor
R6511	T10258	T10243	conj	test,monitor
R6512	T10259	T10260	det	the,state
R6513	T10260	T10258	dobj	state,test
R6514	T10261	T10260	compound	phosphorylation,state
R6515	T10262	T10260	prep	of,state
R6516	T10263	T10262	pobj	SOX9,of
R6517	T10264	T10258	advcl	using,test
R6518	T10265	T10266	advmod	previously,described
R6519	T10266	T10267	amod	described,reagents
R6520	T10267	T10264	dobj	reagents,using
R6521	T10268	T10269	punct	(,Lefebvre
R6522	T10269	T10258	meta	Lefebvre,test
R6523	T10270	T10269	nmod	et,Lefebvre
R6524	T10271	T10269	nmod	al.,Lefebvre
R6525	T10272	T10269	nummod	1998,Lefebvre
R6526	T10273	T10269	punct	;,Lefebvre
R6527	T10274	T10269	nmod	Huang,Lefebvre
R6528	T10275	T10269	nmod	et,Lefebvre
R6529	T10276	T10269	nmod	al.,Lefebvre
R6530	T10277	T10269	nummod	2000,Lefebvre
R6531	T10278	T10269	punct	),Lefebvre
R6532	T10279	T10241	punct	", ",been
R6533	T10280	T10241	nsubj	we,been
R6534	T10281	T10241	aux	have,been
R6535	T10282	T10241	acomp	unable,been
R6536	T10283	T10284	aux	to,obtain
R6537	T10284	T10282	xcomp	obtain,unable
R6538	T10285	T10286	amod	specific,signal
R6539	T10286	T10284	dobj	signal,obtain
R6540	T10287	T10284	prep	at,obtain
R6541	T10288	T10289	det	the,stages
R6542	T10289	T10287	pobj	stages,at
R6543	T10290	T10289	amod	late,stages
R6544	T10291	T10289	amod	postnatal,stages
R6545	T10292	T10289	acl	required,stages
R6546	T10293	T10294	punct	(,data
R6547	T10294	T10241	meta	data,been
R6548	T10295	T10294	amod	unpublished,data
R6549	T10296	T10294	punct	),data
R6550	T10297	T10241	punct	.,been
R6551	T10299	T10300	advmod	Furthermore,cause
R6552	T10301	T10300	punct	", ",cause
R6553	T10302	T10303	amod	null,mutations
R6554	T10303	T10300	nsubj	mutations,cause
R6555	T10304	T10303	prep	in,mutations
R6556	T10305	T10306	compound	L,Sox5
R6557	T10306	T10304	pobj	Sox5,in
R6558	T10307	T10306	punct	-,Sox5
R6559	T10308	T10306	cc	or,Sox5
R6560	T10309	T10306	conj	Sox,Sox5
R6561	T10310	T10309	punct	-,Sox
R6562	T10311	T10309	nummod	6,Sox
R6563	T10312	T10300	dobj	lethality,cause
R6564	T10313	T10312	prep	at,lethality
R6565	T10314	T10313	cc	or,at
R6566	T10315	T10316	advmod	soon,after
R6567	T10316	T10313	conj	after,at
R6568	T10317	T10316	pobj	birth,after
R6569	T10318	T10300	punct	", ",cause
R6570	T10319	T10300	cc	and,cause
R6571	T10320	T10321	det	no,effect
R6572	T10321	T10322	nsubjpass	effect,reported
R6573	T10322	T10300	conj	reported,cause
R6574	T10323	T10321	prep	on,effect
R6575	T10324	T10325	compound	cartilage,maintenance
R6576	T10325	T10323	pobj	maintenance,on
R6577	T10326	T10322	aux	has,reported
R6578	T10327	T10322	auxpass	been,reported
R6579	T10328	T10329	punct	(,Smits
R6580	T10329	T10322	meta	Smits,reported
R6581	T10330	T10329	nmod	et,Smits
R6582	T10331	T10329	nmod	al.,Smits
R6583	T10332	T10329	nummod	2001,Smits
R6584	T10333	T10329	punct	),Smits
R6585	T10334	T10322	punct	.,reported
R6586	T10336	T10337	advmod	However,seems
R6587	T10338	T10337	punct	", ",seems
R6588	T10339	T10337	nsubj	it,seems
R6589	T10340	T10337	oprd	likely,seems
R6590	T10341	T10342	mark	that,cooperate
R6591	T10342	T10337	ccomp	cooperate,seems
R6592	T10343	T10342	nsubj	these,cooperate
R6593	T10344	T10343	cc	or,these
R6594	T10345	T10346	amod	other,processes
R6595	T10346	T10343	conj	processes,these
R6596	T10347	T10346	acl	regulated,processes
R6597	T10348	T10347	agent	by,regulated
R6598	T10349	T10350	compound	BMP,signaling
R6599	T10350	T10348	pobj	signaling,by
R6600	T10351	T10342	prep	with,cooperate
R6601	T10352	T10351	pobj	SOX9,with
R6602	T10353	T10354	aux	to,induce
R6603	T10354	T10342	advcl	induce,cooperate
R6604	T10355	T10356	amod	target,genes
R6605	T10356	T10354	dobj	genes,induce
R6606	T10357	T10354	prep	in,induce
R6607	T10358	T10359	amod	articular,cartilage
R6608	T10359	T10357	pobj	cartilage,in
R6609	T10360	T10337	punct	.,seems
R6610	T10362	T10363	nsubj	Mutation,disrupts
R6611	T10364	T10362	prep	of,Mutation
R6612	T10365	T10364	pobj	Smad3,of
R6613	T10366	T10362	cc	or,Mutation
R6614	T10367	T10362	conj	expression,Mutation
R6615	T10368	T10367	prep	of,expression
R6616	T10369	T10370	amod	dominant,receptor
R6617	T10370	T10368	pobj	receptor,of
R6618	T10371	T10370	amod	negative,receptor
R6619	T10372	T10373	amod	transforming,β
R6620	T10373	T10370	nmod	β,receptor
R6621	T10374	T10373	nmod	growth,β
R6622	T10375	T10373	nmod	factor,β
R6623	T10376	T10373	punct	(,β
R6624	T10377	T10378	compound	TGF,β
R6625	T10378	T10373	appos	β,β
R6626	T10379	T10378	punct	-,β
R6627	T10380	T10373	punct	),β
R6628	T10381	T10370	nmod	type,receptor
R6629	T10382	T10381	nummod	II,type
R6630	T10383	T10363	advmod	also,disrupts
R6631	T10384	T10385	amod	normal,maintenance
R6632	T10385	T10363	dobj	maintenance,disrupts
R6633	T10386	T10387	amod	articular,cartilage
R6634	T10387	T10385	compound	cartilage,maintenance
R6635	T10388	T10389	punct	(,Serra
R6636	T10389	T10363	meta	Serra,disrupts
R6637	T10390	T10389	nmod	et,Serra
R6638	T10391	T10389	nmod	al.,Serra
R6639	T10392	T10389	nummod	1997,Serra
R6640	T10393	T10389	punct	;,Serra
R6641	T10394	T10389	nmod	Yang,Serra
R6642	T10395	T10389	nmod	et,Serra
R6643	T10396	T10389	nmod	al.,Serra
R6644	T10397	T10389	nummod	2001,Serra
R6645	T10398	T10389	punct	),Serra
R6646	T10399	T10363	punct	.,disrupts
R6647	T10401	T10402	det	Both,manipulations
R6648	T10402	T10403	nsubj	manipulations,disrupt
R6649	T10404	T10403	aux	should,disrupt
R6650	T10405	T10403	dobj	TGFβ,disrupt
R6651	T10406	T10407	amod	rather,than
R6652	T10407	T10405	prep	than,TGFβ
R6653	T10408	T10409	compound	BMP,signaling
R6654	T10409	T10407	pobj	signaling,than
R6655	T10410	T10403	punct	", ",disrupt
R6656	T10411	T10403	cc	and,disrupt
R6657	T10412	T10413	det	both,manipulations
R6658	T10413	T10414	nsubj	manipulations,cause
R6659	T10414	T10403	conj	cause,disrupt
R6660	T10415	T10416	amod	articular,cartilage
R6661	T10416	T10417	nsubj	cartilage,hypertrophy
R6662	T10417	T10414	ccomp	hypertrophy,cause
R6663	T10418	T10417	aux	to,hypertrophy
R6664	T10419	T10417	cc	and,hypertrophy
R6665	T10420	T10421	auxpass	be,replaced
R6666	T10421	T10417	conj	replaced,hypertrophy
R6667	T10422	T10421	agent	by,replaced
R6668	T10423	T10422	pobj	bone,by
R6669	T10424	T10414	punct	.,cause
R6670	T10426	T10427	prep	In,showed
R6671	T10428	T10426	pobj	contrast,In
R6672	T10429	T10427	punct	", ",showed
R6673	T10430	T10431	poss	our,analysis
R6674	T10431	T10427	nsubj	analysis,showed
R6675	T10432	T10431	prep	of,analysis
R6676	T10433	T10434	nmod	Bmpr1a,mutant
R6677	T10434	T10435	nmod	mutant,cartilage
R6678	T10435	T10432	pobj	cartilage,of
R6679	T10436	T10435	amod	articular,cartilage
R6680	T10437	T10438	det	a,loss
R6681	T10438	T10427	dobj	loss,showed
R6682	T10439	T10438	prep	of,loss
R6683	T10440	T10441	compound	ECM,components
R6684	T10441	T10439	pobj	components,of
R6685	T10442	T10438	punct	", ",loss
R6686	T10443	T10438	cc	but,loss
R6687	T10444	T10445	det	no,signs
R6688	T10445	T10438	conj	signs,loss
R6689	T10446	T10445	prep	of,signs
R6690	T10447	T10446	pobj	hypertrophy,of
R6691	T10448	T10447	cc	or,hypertrophy
R6692	T10449	T10450	compound	bone,replacement
R6693	T10450	T10447	conj	replacement,hypertrophy
R6694	T10451	T10427	punct	.,showed
R6695	T10453	T10454	advmod	Therefore,playing
R6696	T10455	T10454	punct	", ",playing
R6697	T10456	T10457	nmod	TGFβ,signaling
R6698	T10457	T10454	nsubj	signaling,playing
R6699	T10458	T10456	cc	and,TGFβ
R6700	T10459	T10456	conj	BMP,TGFβ
R6701	T10460	T10454	aux	are,playing
R6702	T10461	T10462	amod	distinct,roles
R6703	T10462	T10454	dobj	roles,playing
R6704	T10463	T10461	cc	but,distinct
R6705	T10464	T10461	conj	necessary,distinct
R6706	T10465	T10466	aux	to,maintain
R6707	T10466	T10462	advcl	maintain,roles
R6708	T10467	T10468	amod	articular,cartilage
R6709	T10468	T10466	dobj	cartilage,maintain
R6710	T10469	T10454	punct	.,playing
R6711	T10471	T10472	mark	Although,isolated
R6712	T10472	T10476	advcl	isolated,stimulated
R6713	T10473	T10472	nsubjpass	BMPs,isolated
R6714	T10474	T10472	auxpass	were,isolated
R6715	T10475	T10472	advmod	originally,isolated
R6716	T10477	T10472	prep	on,isolated
R6717	T10478	T10479	det	the,basis
R6718	T10479	T10477	pobj	basis,on
R6719	T10480	T10479	prep	of,basis
R6720	T10481	T10482	poss	their,ability
R6721	T10482	T10480	pobj	ability,of
R6722	T10483	T10484	aux	to,induce
R6723	T10484	T10482	acl	induce,ability
R6724	T10485	T10486	amod	ectopic,formation
R6725	T10486	T10484	dobj	formation,induce
R6726	T10487	T10486	compound	bone,formation
R6727	T10488	T10476	punct	", ",stimulated
R6728	T10489	T10490	poss	their,presence
R6729	T10490	T10476	nsubj	presence,stimulated
R6730	T10521	T10520	nmod	et,Erlacher
R6731	T10491	T10490	prep	in,presence
R6732	T10522	T10520	nmod	al.,Erlacher
R6733	T10492	T10493	amod	articular,cartilage
R6734	T10523	T10520	nummod	1998,Erlacher
R6735	T10493	T10491	pobj	cartilage,in
R6736	T10494	T10490	cc	and,presence
R6737	T10524	T10520	punct	;,Erlacher
R6738	T10495	T10496	amod	strong,effect
R6739	T10525	T10520	conj	Edwards,Erlacher
R6740	T10526	T10525	cc	and,Edwards
R6741	T10496	T10490	conj	effect,presence
R6742	T10527	T10525	conj	Francis,Edwards
R6743	T10528	T10527	punct	-,Francis
R6744	T10497	T10496	prep	on,effect
R6745	T10529	T10527	nmod	West,Francis
R6746	T10530	T10527	nummod	2001,Francis
R6747	T10531	T10527	punct	;,Francis
R6748	T10498	T10499	compound	cartilage,formation
R6749	T10532	T10527	conj	Chubinskaya,Francis
R6750	T10533	T10532	cc	and,Chubinskaya
R6751	T10499	T10497	pobj	formation,on
R6752	T10534	T10532	conj	Kuettner,Chubinskaya
R6753	T10535	T10534	nummod	2003,Kuettner
R6754	T10500	T10476	aux	has,stimulated
R6755	T10536	T10534	punct	),Kuettner
R6756	T10537	T10476	punct	.,stimulated
R6757	T10539	T10540	det	The,failure
R6758	T10540	T10541	nsubj	failure,suggests
R6759	T10501	T10476	dobj	interest,stimulated
R6760	T10542	T10543	aux	to,maintain
R6761	T10543	T10540	acl	maintain,failure
R6762	T10502	T10501	prep	in,interest
R6763	T10544	T10545	amod	articular,cartilage
R6764	T10545	T10543	dobj	cartilage,maintain
R6765	T10546	T10543	prep	in,maintain
R6766	T10503	T10502	pcomp	using,in
R6767	T10547	T10548	det	the,absence
R6768	T10548	T10546	pobj	absence,in
R6769	T10549	T10548	prep	of,absence
R6770	T10504	T10503	dobj	them,using
R6771	T10550	T10551	amod	normal,function
R6772	T10551	T10549	pobj	function,of
R6773	T10505	T10506	aux	to,repair
R6774	T10552	T10551	compound	BMPR1A,function
R6775	T10506	T10503	advcl	repair,using
R6776	T10553	T10554	mark	that,be
R6777	T10554	T10541	ccomp	be,suggests
R6778	T10555	T10554	nsubj	ligands,be
R6779	T10556	T10555	cc	or,ligands
R6780	T10557	T10558	amod	small,agonists
R6781	T10507	T10506	cc	or,repair
R6782	T10558	T10555	conj	agonists,ligands
R6783	T10559	T10558	compound	molecule,agonists
R6784	T10560	T10561	dep	that,interact
R6785	T10508	T10506	conj	regenerate,repair
R6786	T10561	T10555	relcl	interact,ligands
R6787	T10562	T10561	advmod	specifically,interact
R6788	T10563	T10561	prep	with,interact
R6789	T10509	T10510	compound	cartilage,defects
R6790	T10564	T10565	det	this,subtype
R6791	T10565	T10563	pobj	subtype,with
R6792	T10566	T10565	compound	receptor,subtype
R6793	T10510	T10508	dobj	defects,regenerate
R6794	T10567	T10554	aux	may,be
R6795	T10568	T10569	advmod	particularly,good
R6796	T10569	T10570	amod	good,candidates
R6797	T10511	T10508	prep	in,regenerate
R6798	T10570	T10554	attr	candidates,be
R6799	T10571	T10570	prep	for,candidates
R6800	T10512	T10513	compound	adult,animals
R6801	T10572	T10571	pcomp	designing,for
R6802	T10573	T10574	amod	new,approaches
R6803	T10574	T10572	dobj	approaches,designing
R6804	T10513	T10511	pobj	animals,in
R6805	T10575	T10576	aux	to,maintain
R6806	T10576	T10574	acl	maintain,approaches
R6807	T10514	T10515	punct	(,Chang
R6808	T10577	T10576	cc	or,maintain
R6809	T10578	T10576	conj	heal,maintain
R6810	T10579	T10580	amod	articular,cartilage
R6811	T10580	T10578	dobj	cartilage,heal
R6812	T10581	T10578	prep	at,heal
R6813	T10582	T10583	amod	postnatal,stages
R6814	T10515	T10476	meta	Chang,stimulated
R6815	T10583	T10581	pobj	stages,at
R6816	T10584	T10541	punct	.,suggests
R6817	T10516	T10515	nmod	et,Chang
R6818	T10586	T10587	nsubj	Lack,results
R6819	T10517	T10515	nmod	al.,Chang
R6820	T10588	T10586	prep	of,Lack
R6821	T10589	T10590	compound	Bmpr1a,function
R6822	T10590	T10588	pobj	function,of
R6823	T10518	T10515	nummod	1994,Chang
R6824	T10591	T10590	prep	in,function
R6825	T10592	T10593	amod	articular,cartilage
R6826	T10519	T10515	punct	;,Chang
R6827	T10593	T10591	pobj	cartilage,in
R6828	T10520	T10515	conj	Erlacher,Chang
R6829	T10594	T10587	prep	in,results
R6830	T10595	T10596	amod	severe,fibrillation
R6831	T10596	T10594	pobj	fibrillation,in
R6832	T10597	T10596	prep	of,fibrillation
R6833	T10627	T10625	pobj	signaling,in
R6834	T10598	T10599	det	the,surface
R6835	T10628	T10623	advmod	also,contribute
R6836	T10599	T10597	pobj	surface,of
R6837	T10600	T10599	amod	articular,surface
R6838	T10601	T10596	cc	and,fibrillation
R6839	T10629	T10623	prep	to,contribute
R6840	T10602	T10596	conj	loss,fibrillation
R6841	T10603	T10602	prep	of,loss
R6842	T10630	T10631	amod	human,disease
R6843	T10604	T10605	compound	joint,mobility
R6844	T10605	T10603	pobj	mobility,of
R6845	T10606	T10587	punct	.,results
R6846	T10631	T10629	pobj	disease,to
R6847	T10608	T10609	det	The,development
R6848	T10609	T10610	nsubj	development,raises
R6849	T10632	T10631	compound	joint,disease
R6850	T10633	T10610	punct	.,raises
R6851	T10611	T10609	prep	of,development
R6852	T10635	T10636	nsubjpass	Osteoarthritis,known
R6853	T10612	T10613	amod	severe,symptoms
R6854	T10613	T10611	pobj	symptoms,of
R6855	T10614	T10613	compound	arthritis,symptoms
R6856	T10615	T10609	prep	in,development
R6857	T10637	T10636	auxpass	is,known
R6858	T10616	T10617	npadvmod	Bmpr1a,deficient
R6859	T10617	T10619	amod	deficient,mice
R6860	T10618	T10617	punct	-,deficient
R6861	T10619	T10615	pobj	mice,in
R6862	T10620	T10621	det	the,possibility
R6863	T10621	T10610	dobj	possibility,raises
R6864	T10638	T10639	aux	to,have
R6865	T10639	T10636	xcomp	have,known
R6866	T10622	T10623	mark	that,contribute
R6867	T10640	T10641	det	a,component
R6868	T10623	T10621	acl	contribute,possibility
R6869	T10624	T10623	nsubj	defects,contribute
R6870	T10641	T10639	dobj	component,have
R6871	T10625	T10624	prep	in,defects
R6872	T10626	T10627	compound	BMP,signaling
R6873	T10642	T10641	amod	significant,component
R6874	T10643	T10641	amod	genetic,component
R6875	T10644	T10636	punct	", ",known
R6876	T10645	T10636	cc	but,known
R6877	T10733	T10731	pobj	study,in
R6878	T10646	T10647	nsubj	it,involves
R6879	T10734	T10725	acomp	heterozygous,were
R6880	T10735	T10734	prep	for,heterozygous
R6881	T10647	T10636	conj	involves,known
R6882	T10736	T10737	det	a,allele
R6883	T10737	T10735	pobj	allele,for
R6884	T10738	T10737	amod	null,allele
R6885	T10648	T10647	advmod	likely,involves
R6886	T10739	T10737	prep	of,allele
R6887	T10740	T10739	pobj	Bmpr1a,of
R6888	T10741	T10725	punct	", ",were
R6889	T10649	T10650	amod	multiple,factors
R6890	T10742	T10725	cc	and,were
R6891	T10743	T10744	nsubj	they,showed
R6892	T10744	T10725	conj	showed,were
R6893	T10650	T10647	dobj	factors,involves
R6894	T10745	T10746	amod	little,sign
R6895	T10746	T10744	dobj	sign,showed
R6896	T10651	T10650	amod	genetic,factors
R6897	T10747	T10746	prep	of,sign
R6898	T10748	T10747	pobj	osteoarthritis,of
R6899	T10749	T10750	advmod	even,late
R6900	T10652	T10653	dep	that,been
R6901	T10750	T10744	advmod	late,showed
R6902	T10751	T10750	prep	in,late
R6903	T10752	T10751	pobj	life,in
R6904	T10653	T10650	relcl	been,factors
R6905	T10753	T10744	punct	.,showed
R6906	T10654	T10653	aux	have,been
R6907	T10755	T10756	amod	Several,regions
R6908	T10756	T10758	nsubjpass	regions,linked
R6909	T10757	T10756	compound	chromosome,regions
R6910	T10655	T10653	acomp	difficult,been
R6911	T10759	T10758	aux	have,linked
R6912	T10760	T10758	auxpass	been,linked
R6913	T10761	T10758	advmod	previously,linked
R6914	T10762	T10758	prep	to,linked
R6915	T10763	T10764	compound	arthritis,phenotypes
R6916	T10656	T10657	aux	to,identify
R6917	T10764	T10762	pobj	phenotypes,to
R6918	T10765	T10758	prep	in,linked
R6919	T10766	T10765	pobj	humans,in
R6920	T10657	T10655	advcl	identify,difficult
R6921	T10767	T10758	advcl	using,linked
R6922	T10768	T10769	preconj	either,studies
R6923	T10769	T10767	dobj	studies,using
R6924	T10658	T10659	punct	(,Spector
R6925	T10770	T10769	compound	association,studies
R6926	T10771	T10769	prep	in,studies
R6927	T10772	T10771	pobj	populations,in
R6928	T10659	T10647	meta	Spector,involves
R6929	T10773	T10769	cc	or,studies
R6930	T10774	T10775	compound	linkage,studies
R6931	T10775	T10769	conj	studies,studies
R6932	T10660	T10659	nmod	et,Spector
R6933	T10776	T10775	prep	in,studies
R6934	T10777	T10776	pobj	families,in
R6935	T10778	T10758	punct	.,linked
R6936	T10661	T10659	nmod	al.,Spector
R6937	T10780	T10781	nsubj	It,is
R6938	T10662	T10659	nummod	1996,Spector
R6939	T10782	T10781	acomp	interesting,is
R6940	T10663	T10659	punct	;,Spector
R6941	T10783	T10784	aux	to,note
R6942	T10664	T10659	nmod	Felson,Spector
R6943	T10784	T10781	xcomp	note,is
R6944	T10665	T10659	nmod	et,Spector
R6945	T10785	T10786	mark	that,contain
R6946	T10786	T10784	ccomp	contain,note
R6947	T10787	T10786	nsubj	several,contain
R6948	T10788	T10787	prep	of,several
R6949	T10666	T10659	nmod	al.,Spector
R6950	T10789	T10790	det	these,regions
R6951	T10790	T10788	pobj	regions,of
R6952	T10791	T10790	compound	chromosome,regions
R6953	T10667	T10659	nummod	1998,Spector
R6954	T10792	T10786	dobj	genes,contain
R6955	T10793	T10792	acl	encoding,genes
R6956	T10668	T10659	punct	;,Spector
R6957	T10794	T10795	amod	different,members
R6958	T10795	T10793	dobj	members,encoding
R6959	T10669	T10659	nmod	Hirsch,Spector
R6960	T10796	T10795	prep	of,members
R6961	T10797	T10798	det	the,pathway
R6962	T10798	T10796	pobj	pathway,of
R6963	T10670	T10659	nmod	et,Spector
R6964	T10799	T10800	compound	BMP,signaling
R6965	T10800	T10798	compound	signaling,pathway
R6966	T10801	T10792	punct	", ",genes
R6967	T10802	T10792	prep	including,genes
R6968	T10803	T10804	det	the,gene
R6969	T10804	T10802	pobj	gene,including
R6970	T10671	T10659	nmod	al.,Spector
R6971	T10805	T10804	compound	BMP5,gene
R6972	T10806	T10804	prep	on,gene
R6973	T10807	T10808	amod	human,6p12
R6974	T10672	T10659	nummod	1998,Spector
R6975	T10808	T10806	pobj	6p12,on
R6976	T10809	T10808	compound	chromosome,6p12
R6977	T10810	T10811	punct	(,Loughlin
R6978	T10673	T10659	punct	),Spector
R6979	T10811	T10804	meta	Loughlin,gene
R6980	T10812	T10811	nmod	et,Loughlin
R6981	T10674	T10647	punct	.,involves
R6982	T10813	T10811	nmod	al.,Loughlin
R6983	T10814	T10811	nummod	2002,Loughlin
R6984	T10815	T10811	punct	),Loughlin
R6985	T10676	T10677	nsubjpass	Humans,known
R6986	T10816	T10804	punct	", ",gene
R6987	T10817	T10818	det	the,gene
R6988	T10818	T10804	conj	gene,gene
R6989	T10819	T10818	compound	MADH1,gene
R6990	T10820	T10818	prep	on,gene
R6991	T10678	T10679	dep	that,are
R6992	T10821	T10822	amod	human,4q26
R6993	T10822	T10820	pobj	4q26,on
R6994	T10823	T10822	compound	chromosome,4q26
R6995	T10824	T10825	punct	–,4q31
R6996	T10679	T10676	relcl	are,Humans
R6997	T10825	T10822	prep	4q31,4q26
R6998	T10680	T10679	acomp	heterozygous,are
R6999	T10826	T10827	punct	(,Leppavuori
R7000	T10827	T10818	meta	Leppavuori,gene
R7001	T10828	T10827	nmod	et,Leppavuori
R7002	T10829	T10827	nmod	al.,Leppavuori
R7003	T10681	T10680	prep	for,heterozygous
R7004	T10830	T10827	nummod	1999,Leppavuori
R7005	T10831	T10827	punct	;,Leppavuori
R7006	T10682	T10683	nmod	loss,mutations
R7007	T10832	T10827	nmod	Kent,Leppavuori
R7008	T10833	T10827	nmod	et,Leppavuori
R7009	T10834	T10827	nmod	al.,Leppavuori
R7010	T10683	T10681	pobj	mutations,for
R7011	T10835	T10827	nummod	2002,Leppavuori
R7012	T10836	T10827	punct	),Leppavuori
R7013	T10837	T10818	punct	", ",gene
R7014	T10684	T10682	punct	-,loss
R7015	T10838	T10818	cc	and,gene
R7016	T10685	T10682	prep	of,loss
R7017	T10686	T10685	punct	-,of
R7018	T10687	T10685	pobj	function,of
R7019	T10839	T10840	det	the,receptor
R7020	T10688	T10683	prep	in,mutations
R7021	T10840	T10818	conj	receptor,gene
R7022	T10841	T10840	compound	BMPR2,receptor
R7023	T10842	T10840	prep	on,receptor
R7024	T10689	T10688	pobj	BMPR1A,in
R7025	T10843	T10844	amod	human,2q33
R7026	T10844	T10842	pobj	2q33,on
R7027	T10845	T10844	compound	chromosome,2q33
R7028	T10690	T10677	auxpass	are,known
R7029	T10846	T10847	punct	(,Wright
R7030	T10847	T10840	meta	Wright,receptor
R7031	T10848	T10847	nmod	et,Wright
R7032	T10691	T10692	aux	to,be
R7033	T10849	T10847	nmod	al.,Wright
R7034	T10850	T10847	nummod	1996,Wright
R7035	T10851	T10847	punct	),Wright
R7036	T10692	T10677	xcomp	be,known
R7037	T10852	T10781	punct	.,is
R7038	T10854	T10855	det	The,nature
R7039	T10693	T10692	prep	at,be
R7040	T10855	T10857	nsubj	nature,suggests
R7041	T10856	T10855	amod	complex,nature
R7042	T10694	T10693	pobj	risk,at
R7043	T10858	T10855	prep	of,nature
R7044	T10695	T10694	prep	for,risk
R7045	T10859	T10860	amod	human,osteoarthritis
R7046	T10860	T10858	pobj	osteoarthritis,of
R7047	T10861	T10862	mark	that,involved
R7048	T10696	T10697	amod	juvenile,polyposis
R7049	T10697	T10695	pobj	polyposis,for
R7050	T10862	T10857	ccomp	involved,suggests
R7051	T10698	T10699	punct	(,Howe
R7052	T10863	T10862	nsubjpass	interactions,involved
R7053	T10864	T10863	prep	between,interactions
R7054	T10865	T10866	amod	multiple,genes
R7055	T10699	T10677	meta	Howe,known
R7056	T10866	T10864	pobj	genes,between
R7057	T10867	T10862	aux	may,involved
R7058	T10868	T10862	auxpass	be,involved
R7059	T10700	T10699	nmod	et,Howe
R7060	T10869	T10862	prep	in,involved
R7061	T10870	T10869	pcomp	modifying,in
R7062	T10701	T10699	nmod	al.,Howe
R7063	T10871	T10870	dobj	susceptibility,modifying
R7064	T10872	T10871	prep	to,susceptibility
R7065	T10873	T10874	det	the,disease
R7066	T10702	T10699	nummod	2001,Howe
R7067	T10874	T10872	pobj	disease,to
R7068	T10875	T10857	punct	.,suggests
R7069	T10877	T10878	det	The,inclusion
R7070	T10878	T10879	nsubj	inclusion,help
R7071	T10703	T10699	punct	;,Howe
R7072	T10880	T10878	prep	of,inclusion
R7073	T10881	T10882	amod	genetic,markers
R7074	T10704	T10699	nmod	Zhou,Howe
R7075	T10882	T10880	pobj	markers,of
R7076	T10883	T10882	prep	near,markers
R7077	T10884	T10885	compound	BMP,components
R7078	T10705	T10699	nmod	et,Howe
R7079	T10885	T10883	pobj	components,near
R7080	T10886	T10885	compound	signaling,components
R7081	T10887	T10879	aux	may,help
R7082	T10706	T10699	nmod	al.,Howe
R7083	T10888	T10879	xcomp	identify,help
R7084	T10889	T10890	amod	additional,loci
R7085	T10890	T10888	dobj	loci,identify
R7086	T10707	T10699	nummod	2001,Howe
R7087	T10891	T10892	compound	osteoarthritis,susceptibility
R7088	T10892	T10890	compound	susceptibility,loci
R7089	T10708	T10699	punct	),Howe
R7090	T10893	T10888	cc	and,identify
R7091	T10894	T10888	conj	facilitate,identify
R7092	T10895	T10896	det	the,search
R7093	T10709	T10677	punct	", ",known
R7094	T10896	T10894	dobj	search,facilitate
R7095	T10897	T10896	prep	for,search
R7096	T10898	T10899	amod	causative,mutations
R7097	T10710	T10677	cc	but,known
R7098	T10899	T10897	pobj	mutations,for
R7099	T10900	T10879	punct	.,help
R7100	T10711	T10712	det	the,risk
R7101	T10902	T10903	nmod	Development,processes
R7102	T10903	T10906	nsubj	processes,been
R7103	T10712	T10713	nsubjpass	risk,reported
R7104	T10904	T10902	cc	and,Development
R7105	T10905	T10902	conj	disease,Development
R7106	T10713	T10677	conj	reported,known
R7107	T10907	T10903	prep	in,processes
R7108	T10908	T10909	amod	synovial,joints
R7109	T10714	T10712	prep	of,risk
R7110	T10909	T10907	pobj	joints,in
R7111	T10910	T10906	aux	have,been
R7112	T10911	T10906	acomp	difficult,been
R7113	T10715	T10714	pobj	osteoarthritis,of
R7114	T10912	T10913	aux	to,study
R7115	T10913	T10911	advcl	study,difficult
R7116	T10716	T10712	prep	for,risk
R7117	T10914	T10913	advmod	genetically,study
R7118	T10915	T10906	punct	", ",been
R7119	T10916	T10917	mark	because,generated
R7120	T10917	T10906	advcl	generated,been
R7121	T10918	T10919	amod	synovial,joints
R7122	T10919	T10917	nsubjpass	joints,generated
R7123	T10920	T10917	auxpass	are,generated
R7124	T10717	T10718	det	these,people
R7125	T10921	T10917	cc	and,generated
R7126	T10922	T10917	conj	function,generated
R7127	T10923	T10917	prep	at,generated
R7128	T10718	T10716	pobj	people,for
R7129	T10924	T10925	advmod	relatively,late
R7130	T10925	T10926	amod	late,stages
R7131	T10926	T10923	pobj	stages,at
R7132	T10719	T10713	aux	has,reported
R7133	T10927	T10926	prep	of,stages
R7134	T10928	T10929	compound	vertebrate,development
R7135	T10929	T10927	pobj	development,of
R7136	T10720	T10713	neg	not,reported
R7137	T10930	T10906	punct	.,been
R7138	T10721	T10713	auxpass	been,reported
R7139	T10932	T10933	det	The,system
R7140	T10933	T10937	nsubj	system,provides
R7141	T10934	T10935	compound	Gdf5,Cre
R7142	T10722	T10713	punct	.,reported
R7143	T10935	T10933	compound	Cre,system
R7144	T10936	T10935	punct	-,Cre
R7145	T10724	T10725	advmod	However,were
R7146	T10938	T10939	det	a,method
R7147	T10939	T10937	dobj	method,provides
R7148	T10940	T10939	amod	new,method
R7149	T10941	T10939	prep	for,method
R7150	T10726	T10725	punct	", ",were
R7151	T10942	T10941	pcomp	restricting,for
R7152	T10943	T10944	compound	gene,expression
R7153	T10944	T10942	dobj	expression,restricting
R7154	T10727	T10728	det	the,mice
R7155	T10728	T10725	nsubj	mice,were
R7156	T10729	T10728	compound	control,mice
R7157	T10945	T10944	cc	or,expression
R7158	T10730	T10728	acl	used,mice
R7159	T10946	T10944	conj	inactivation,expression
R7160	T10947	T10948	advmod	primarily,to
R7161	T10948	T10942	prep	to,restricting
R7162	T10731	T10730	prep	in,used
R7163	T10949	T10950	amod	articular,regions
R7164	T10950	T10948	pobj	regions,to
R7165	T10732	T10733	det	this,study
R7166	T10951	T10942	punct	", ",restricting
R7167	T10952	T10953	advmod	thus,avoiding
R7168	T10953	T10942	advcl	avoiding,restricting
R7169	T10954	T10955	det	the,functions
R7170	T10955	T10953	dobj	functions,avoiding
R7171	T10956	T10955	amod	pleiotropic,functions
R7172	T10957	T10955	prep	of,functions
R7173	T10958	T10959	amod	many,genes
R7174	T10959	T10957	pobj	genes,of
R7175	T10960	T10955	prep	in,functions
R7176	T10961	T10962	amod	other,tissues
R7177	T10962	T10960	pobj	tissues,in
R7178	T10963	T10937	punct	.,provides
R7179	T10965	T10966	prep	Depending,used
R7180	T10967	T10965	prep	on,Depending
R7181	T10968	T10969	det	the,configuration
R7182	T10969	T10967	pobj	configuration,on
R7183	T10970	T10969	prep	of,configuration
R7184	T10971	T10972	det	the,gene
R7185	T10972	T10970	pobj	gene,of
R7186	T10973	T10972	amod	floxed,gene
R7187	T10974	T10972	compound	target,gene
R7188	T10975	T10966	punct	", ",used
R7189	T10976	T10977	det	this,system
R7190	T10977	T10966	nsubjpass	system,used
R7191	T10978	T10966	aux	can,used
R7192	T10979	T10966	auxpass	be,used
R7193	T10980	T10981	aux	to,activate
R7194	T10981	T10966	advcl	activate,used
R7195	T10982	T10981	preconj	either,activate
R7196	T10983	T10984	det	the,expression
R7197	T10984	T10981	dobj	expression,activate
R7198	T10985	T10984	prep	of,expression
R7199	T10986	T10987	det	a,gene
R7200	T10987	T10985	pobj	gene,of
R7201	T10988	T10989	advmod	primarily,in
R7202	T10989	T10981	prep	in,activate
R7203	T10990	T10991	amod	developing,joints
R7204	T10991	T10989	pobj	joints,in
R7205	T10992	T10993	punct	(,ssee
R7206	T10993	T10981	parataxis	ssee,activate
R7207	T10994	T10995	nmod	Figure,1B
R7208	T10995	T10993	dobj	1B,ssee
R7209	T10996	T10997	punct	–,1D
R7210	T10997	T10995	prep	1D,1B
R7211	T10998	T10993	punct	),ssee
R7212	T10999	T10981	punct	", ",activate
R7213	T11000	T10981	cc	or,activate
R7214	T11001	T11002	aux	to,inactivate
R7215	T11002	T10981	conj	inactivate,activate
R7216	T11003	T11004	compound	gene,function
R7217	T11004	T11002	dobj	function,inactivate
R7218	T11005	T11002	prep	in,inactivate
R7219	T11006	T11007	amod	articular,regions
R7220	T11007	T11005	pobj	regions,in
R7221	T11008	T11009	punct	(,see
R7222	T11009	T10966	parataxis	see,used
R7223	T11010	T11009	dobj	Figure,see
R7224	T11011	T11010	nummod	3,Figure
R7225	T11012	T11009	punct	),see
R7226	T11013	T10966	punct	.,used
R7227	T11015	T11016	amod	Additional,studies
R7228	T11016	T11017	nsubj	studies,enhance
R7229	T11018	T11016	prep	with,studies
R7230	T11019	T11020	det	this,system
R7231	T11020	T11018	pobj	system,with
R7232	T11021	T11017	aux	should,enhance
R7233	T11022	T11017	advmod	greatly,enhance
R7234	T11023	T11024	poss	our,knowledge
R7235	T11024	T11017	dobj	knowledge,enhance
R7236	T11025	T11024	prep	of,knowledge
R7237	T11026	T11027	det	the,mechanisms
R7238	T11027	T11025	pobj	mechanisms,of
R7239	T11028	T11027	nmod	development,mechanisms
R7240	T11029	T11028	punct	", ",development
R7241	T11030	T11028	conj	function,development
R7242	T11031	T11030	punct	", ",function
R7243	T11032	T11030	cc	and,function
R7244	T11033	T11030	conj	disease,function
R7245	T11034	T11027	prep	of,mechanisms
R7246	T11035	T11034	pobj	joints,of
R7247	T11036	T11017	punct	", ",enhance
R7248	T11037	T11017	cc	and,enhance
R7266	T11314	T11313	prep	of,Generation
R7267	T11315	T11316	compound	Gdf5,Cre
R7268	T11316	T11318	npadvmod	Cre,transgenic
R7269	T11317	T11316	punct	-,Cre
R7270	T11318	T11319	amod	transgenic,mice
R7271	T11319	T11314	pobj	mice,of
R7272	T11321	T11322	det	A,library
R7273	T11322	T11328	nsubjpass	library,screened
R7274	T11323	T11324	compound	mouse,BAC
R7275	T11324	T11322	compound	BAC,library
R7276	T11325	T11326	compound	129x1,SvJ
R7277	T11326	T11324	compound	SvJ,BAC
R7278	T11327	T11326	punct	/,SvJ
R7279	T11329	T11330	punct	(,Invitrogen
R7280	T11330	T11322	parataxis	Invitrogen,library
R7281	T11331	T11330	punct	),Invitrogen
R7282	T11332	T11328	auxpass	was,screened
R7283	T11333	T11334	aux	to,identify
R7284	T11334	T11328	advcl	identify,screened
R7285	T11335	T11336	det	a,BAC
R7286	T11336	T11334	dobj	BAC,identify
R7287	T11337	T11338	nummod	140,kb
R7288	T11338	T11336	compound	kb,BAC
R7289	T11339	T11338	punct	-,kb
R7290	T11340	T11336	prep	from,BAC
R7291	T11341	T11342	det	the,locus
R7292	T11342	T11340	pobj	locus,from
R7293	T11343	T11342	compound	Gdf5,locus
R7294	T11344	T11328	punct	.,screened
R7295	T11346	T11347	det	This,BAC
R7296	T11347	T11348	nsubjpass	BAC,modified
R7297	T11349	T11348	auxpass	was,modified
R7298	T11350	T11348	advcl	using,modified
R7299	T11351	T11352	det	a,system
R7300	T11352	T11350	dobj	system,using
R7301	T11353	T11354	amod	homologous,recombination
R7302	T11354	T11352	compound	recombination,system
R7303	T11355	T11350	prep	in,using
R7304	T11356	T11357	compound	E.,coli
R7305	T11357	T11355	pobj	coli,in
R7306	T11358	T11359	punct	(,Yang
R7307	T11359	T11350	meta	Yang,using
R7308	T11360	T11359	nmod	et,Yang
R7309	T11361	T11359	nmod	al.,Yang
R7310	T11362	T11359	nummod	1997,Yang
R7311	T11363	T11359	punct	),Yang
R7312	T11364	T11365	aux	to,place
R7313	T11365	T11350	advcl	place,using
R7314	T11366	T11367	amod	nuclear,localized
R7315	T11367	T11369	amod	localized,recombinase
R7316	T11368	T11367	punct	-,localized
R7317	T11369	T11365	dobj	recombinase,place
R7318	T11370	T11369	compound	Cre,recombinase
R7319	T11371	T11369	punct	(,recombinase
R7320	T11372	T11369	prep	from,recombinase
R7321	T11373	T11374	compound	plasmid,pML78
R7322	T11374	T11372	pobj	pML78,from
R7323	T11375	T11376	punct	", ",gift
R7324	T11376	T11374	parataxis	gift,pML78
R7325	T11377	T11376	prep	of,gift
R7326	T11378	T11379	compound	Gail,Martin
R7327	T11379	T11377	pobj	Martin,of
R7328	T11380	T11369	punct	),recombinase
R7329	T11381	T11369	acl	followed,recombinase
R7330	T11382	T11381	agent	by,followed
R7331	T11383	T11384	compound	IRES,hPLAP
R7332	T11384	T11382	pobj	hPLAP,by
R7333	T11385	T11384	punct	-,hPLAP
R7334	T11386	T11384	punct	(,hPLAP
R7335	T11387	T11384	prep	from,hPLAP
R7336	T11388	T11387	pobj	plasmid,from
R7337	T11389	T11388	nummod	1726,plasmid
R7338	T11390	T11388	punct	", ",plasmid
R7339	T11391	T11388	parataxis	gift,plasmid
R7340	T11392	T11391	prep	of,gift
R7341	T11393	T11394	compound	Oliver,Bogler
R7342	T11394	T11392	pobj	Bogler,of
R7343	T11395	T11384	punct	),hPLAP
R7344	T11396	T11397	advmod	directly,behind
R7345	T11397	T11384	prep	behind,hPLAP
R7346	T11398	T11399	det	the,site
R7347	T11399	T11397	pobj	site,behind
R7348	T11400	T11399	compound	ATG,site
R7349	T11401	T11399	compound	start,site
R7350	T11402	T11399	prep	of,site
R7351	T11403	T11402	pobj	Gdf5,of
R7352	T11404	T11348	punct	.,modified
R7353	T11406	T11407	prep	In,removed
R7354	T11408	T11409	det	the,process
R7355	T11409	T11406	pobj	process,In
R7356	T11410	T11407	punct	", ",removed
R7357	T11411	T11412	nummod	583,bp
R7358	T11412	T11407	nsubjpass	bp,removed
R7359	T11413	T11412	prep	of,bp
R7360	T11414	T11415	det	the,exon
R7361	T11415	T11413	pobj	exon,of
R7362	T11416	T11415	amod	first,exon
R7363	T11417	T11415	prep	of,exon
R7364	T11418	T11417	pobj	Gdf5,of
R7365	T11419	T11407	auxpass	was,removed
R7366	T11420	T11407	cc	and,removed
R7367	T11421	T11422	det	no,protein
R7368	T11422	T11425	nsubjpass	protein,predicted
R7369	T11423	T11422	amod	functional,protein
R7370	T11424	T11422	compound	GDF5,protein
R7371	T11425	T11407	conj	predicted,removed
R7372	T11426	T11425	auxpass	is,predicted
R7373	T11427	T11428	aux	to,produced
R7374	T11428	T11425	xcomp	produced,predicted
R7375	T11429	T11428	auxpass	be,produced
R7376	T11430	T11425	punct	.,predicted
R7377	T11432	T11433	det	The,arm
R7378	T11433	T11437	nsubjpass	arm,subcloned
R7379	T11434	T11433	nummod	5,arm
R7380	T11435	T11434	punct	′,5
R7381	T11436	T11433	compound	homology,arm
R7382	T11438	T11437	auxpass	was,subcloned
R7383	T11439	T11437	prep	from,subcloned
R7384	T11440	T11441	det	a,product
R7385	T11441	T11439	pobj	product,from
R7386	T11442	T11441	compound	PCR,product
R7387	T11443	T11441	acl	tailed,product
R7388	T11444	T11443	prep	with,tailed
R7389	T11445	T11446	nmod	XhoI,sites
R7390	T11446	T11444	pobj	sites,with
R7391	T11447	T11445	cc	and,XhoI
R7392	T11448	T11445	conj	Bsp120I,XhoI
R7393	T11449	T11446	compound	restriction,sites
R7394	T11450	T11451	dep	that,contains
R7395	T11451	T11441	relcl	contains,product
R7396	T11452	T11453	nummod	781,bp
R7397	T11453	T11451	dobj	bp,contains
R7398	T11454	T11453	prep	of,bp
R7399	T11455	T11456	nummod	5,sequence
R7400	T11456	T11454	pobj	sequence,of
R7401	T11457	T11455	punct	′,5
R7402	T11458	T11456	amod	genomic,sequence
R7403	T11459	T11456	compound	Gdf5,sequence
R7404	T11460	T11456	acl	ending,sequence
R7405	T11461	T11460	prep	at,ending
R7406	T11462	T11463	det	the,site
R7407	T11463	T11461	pobj	site,at
R7408	T11464	T11465	compound	ATG,translation
R7409	T11465	T11463	compound	translation,site
R7410	T11466	T11463	compound	start,site
R7411	T11467	T11468	punct	(,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7412	T11468	T11460	parataxis	GTTTGGGCCCATCCTCTGGCCAGCCGCTG,ending
R7413	T11469	T11470	amod	forward,primer
R7414	T11470	T11471	dep	primer,CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC
R7415	T11471	T11468	dep	CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7416	T11472	T11471	nummod	5,CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC
R7417	T11473	T11472	punct	′,5
R7418	T11474	T11471	punct	-,CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC
R7419	T11475	T11471	punct	-,CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC
R7420	T11476	T11471	nummod	3,CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC
R7421	T11477	T11471	punct	′,CTGTCTCGAGATGAGGTGGAGGTGAAGACCCC
R7422	T11478	T11468	punct	;,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7423	T11479	T11468	amod	reverse,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7424	T11480	T11468	nummod	5,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7425	T11481	T11480	punct	′,5
R7426	T11482	T11468	punct	-,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7427	T11483	T11468	punct	-,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7428	T11484	T11468	nummod	3,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7429	T11485	T11468	punct	′,GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7430	T11486	T11468	punct	),GTTTGGGCCCATCCTCTGGCCAGCCGCTG
R7431	T11487	T11437	punct	.,subcloned
R7432	T11489	T11490	nsubjpass	Cre,subcloned
R7433	T11491	T11490	auxpass	was,subcloned
R7434	T11492	T11490	prep	from,subcloned
R7435	T11493	T11494	det	a,fragment
R7436	T11494	T11492	pobj	fragment,from
R7437	T11495	T11496	nummod	1.1,kb
R7438	T11496	T11494	compound	kb,fragment
R7439	T11497	T11496	punct	-,kb
R7440	T11498	T11499	compound	Bsp120I,EcoRI
R7441	T11499	T11494	compound	EcoRI,fragment
R7442	T11500	T11499	punct	/,EcoRI
R7443	T11501	T11494	prep	of,fragment
R7444	T11502	T11501	pobj	pML78,of
R7445	T11503	T11490	punct	.,subcloned
R7446	T11505	T11506	compound	IRES,hPLAP
R7447	T11506	T11507	nsubjpass	hPLAP,subcloned
R7448	T11508	T11507	auxpass	was,subcloned
R7449	T11509	T11507	prep	from,subcloned
R7450	T11510	T11511	det	a,product
R7451	T11511	T11509	pobj	product,from
R7452	T11512	T11513	nummod	2.1,kb
R7453	T11513	T11511	compound	kb,product
R7454	T11514	T11513	punct	-,kb
R7455	T11515	T11511	compound	PCR,product
R7456	T11516	T11511	acl	tailed,product
R7457	T11517	T11516	prep	with,tailed
R7458	T11518	T11519	nmod	EcoRI,sites
R7459	T11519	T11517	pobj	sites,with
R7460	T11520	T11518	cc	and,EcoRI
R7461	T11521	T11518	conj	SpeI,EcoRI
R7462	T11522	T11523	dep	that,contains
R7463	T11523	T11511	relcl	contains,product
R7464	T11524	T11525	det	the,site
R7465	T11525	T11523	dobj	site,contains
R7466	T11526	T11527	compound	hPLAP,translation
R7467	T11527	T11525	compound	translation,site
R7468	T11528	T11525	compound	stop,site
R7469	T11529	T11530	punct	(,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7470	T11530	T11525	parataxis	AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG,site
R7471	T11531	T11532	amod	forward,primer
R7472	T11532	T11533	dep	primer,ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG
R7473	T11533	T11530	dep	ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7474	T11534	T11533	nummod	5,ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG
R7475	T11535	T11534	punct	′,5
R7476	T11536	T11533	punct	-,ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG
R7477	T11537	T11533	punct	-,ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG
R7478	T11538	T11533	nummod	3,ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG
R7479	T11539	T11533	punct	′,ATCTCTCGAGGAATTCTCCACCATATTGCCGTCTTTTG
R7480	T11540	T11530	punct	;,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7481	T11541	T11530	amod	reverse,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7482	T11542	T11530	nummod	5,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7483	T11543	T11542	punct	′,5
R7484	T11544	T11530	punct	-,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7485	T11545	T11530	punct	-,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7486	T11546	T11530	nummod	3,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7487	T11547	T11530	punct	′,AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7488	T11548	T11530	punct	),AGAACTCGAGACTAGTCGGGACACTCAGGGAGTAGTGG
R7489	T11549	T11507	punct	.,subcloned
R7490	T11551	T11552	det	The,arm
R7491	T11552	T11556	nsubjpass	arm,subcloned
R7492	T11553	T11552	nummod	3,arm
R7493	T11554	T11553	punct	′,3
R7494	T11555	T11552	compound	homology,arm
R7495	T11557	T11556	auxpass	was,subcloned
R7496	T11558	T11556	prep	from,subcloned
R7497	T11559	T11560	det	a,product
R7498	T11560	T11558	pobj	product,from
R7499	T11561	T11562	nummod	0.8,kb
R7500	T11562	T11560	compound	kb,product
R7501	T11563	T11562	punct	-,kb
R7502	T11564	T11560	compound	PCR,product
R7503	T11565	T11560	acl	amplified,product
R7504	T11566	T11565	prep	from,amplified
R7505	T11567	T11568	det	a,subclone
R7506	T11568	T11566	pobj	subclone,from
R7507	T11569	T11570	nummod	0.9,kb
R7508	T11570	T11568	nmod	kb,subclone
R7509	T11571	T11570	punct	-,kb
R7510	T11572	T11573	nmod	XhoI,Gdf5
R7511	T11573	T11568	nmod	Gdf5,subclone
R7512	T11574	T11568	amod	genomic,subclone
R7513	T11575	T11568	acl	containing,subclone
R7514	T11576	T11575	dobj	part,containing
R7515	T11577	T11576	prep	of,part
R7516	T11578	T11579	det	the,exon
R7517	T11579	T11577	pobj	exon,of
R7518	T11580	T11579	amod	first,exon
R7519	T11581	T11579	cc	and,exon
R7520	T11582	T11583	amod	downstream,intron
R7521	T11583	T11579	conj	intron,exon
R7522	T11584	T11556	punct	.,subcloned
R7523	T11586	T11587	det	The,primer
R7524	T11587	T11589	nsubj	primer,contains
R7525	T11588	T11587	amod	forward,primer
R7526	T11589	T11590	ccomp	contains,is
R7527	T11591	T11592	det	the,end
R7528	T11592	T11589	dobj	end,contains
R7529	T11593	T11592	nummod	3,end
R7530	T11594	T11593	punct	′,3
R7531	T11595	T11592	prep	of,end
R7532	T11596	T11597	det	the,exon
R7533	T11597	T11595	pobj	exon,of
R7534	T11598	T11597	amod	first,exon
R7535	T11599	T11589	cc	and,contains
R7536	T11600	T11601	auxpass	is,tailed
R7537	T11601	T11589	conj	tailed,contains
R7538	T11602	T11601	prep	with,tailed
R7539	T11603	T11604	det	a,site
R7540	T11604	T11602	pobj	site,with
R7541	T11605	T11604	compound	SpeI,site
R7542	T11606	T11590	punct	;,is
R7543	T11607	T11608	det	the,primer
R7544	T11608	T11590	nsubj	primer,is
R7545	T11609	T11608	amod	reverse,primer
R7546	T11610	T11590	prep	from,is
R7547	T11611	T11612	det	the,promoter
R7548	T11612	T11610	pobj	promoter,from
R7549	T11613	T11612	compound	T7,promoter
R7550	T11614	T11612	prep	of,promoter
R7551	T11615	T11616	det	the,vector
R7552	T11616	T11614	pobj	vector,of
R7553	T11617	T11616	acl	containing,vector
R7554	T11618	T11619	det	the,subclone
R7555	T11619	T11617	dobj	subclone,containing
R7556	T11620	T11621	nummod	0.9,kb
R7557	T11621	T11619	compound	kb,subclone
R7558	T11622	T11621	punct	-,kb
R7559	T11623	T11590	cc	and,is
R7560	T11624	T11590	conj	flanks,is
R7561	T11625	T11626	det	the,site
R7562	T11626	T11624	dobj	site,flanks
R7563	T11627	T11628	amod	intronic,XhoI
R7564	T11628	T11626	compound	XhoI,site
R7565	T11629	T11630	punct	(,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7566	T11630	T11626	parataxis	GATTTCTAGAGTAATACGACTCACTATAGGGC,site
R7567	T11631	T11632	amod	forward,primer
R7568	T11632	T11633	dep	primer,CTAAACTAGTCACCAGCTTTATTGACAAAGG
R7569	T11633	T11630	dep	CTAAACTAGTCACCAGCTTTATTGACAAAGG,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7570	T11634	T11633	nummod	5,CTAAACTAGTCACCAGCTTTATTGACAAAGG
R7571	T11635	T11634	punct	′,5
R7572	T11636	T11633	punct	-,CTAAACTAGTCACCAGCTTTATTGACAAAGG
R7573	T11637	T11633	punct	-,CTAAACTAGTCACCAGCTTTATTGACAAAGG
R7574	T11638	T11633	nummod	3,CTAAACTAGTCACCAGCTTTATTGACAAAGG
R7575	T11639	T11633	punct	′,CTAAACTAGTCACCAGCTTTATTGACAAAGG
R7576	T11640	T11630	punct	;,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7577	T11641	T11630	amod	reverse,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7578	T11642	T11630	nummod	5,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7579	T11643	T11642	punct	′,5
R7580	T11644	T11630	punct	-,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7581	T11645	T11630	punct	-,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7582	T11646	T11630	nummod	3,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7583	T11647	T11630	punct	′,GATTTCTAGAGTAATACGACTCACTATAGGGC
R7584	T11648	T11630	punct	),GATTTCTAGAGTAATACGACTCACTATAGGGC
R7585	T11649	T11590	punct	.,is
R7586	T11651	T11652	det	The,construct
R7587	T11652	T11654	nsubjpass	construct,built
R7588	T11653	T11652	compound	targeting,construct
R7589	T11655	T11654	auxpass	was,built
R7590	T11656	T11654	cc	and,built
R7591	T11657	T11654	conj	verified,built
R7592	T11658	T11657	prep	in,verified
R7593	T11659	T11658	pobj	pBSSK,in
R7594	T11660	T11661	punct	(,Stratagene
R7595	T11661	T11659	parataxis	Stratagene,pBSSK
R7596	T11662	T11661	punct	", ",Stratagene
R7597	T11663	T11664	compound	La,Jolla
R7598	T11664	T11661	npadvmod	Jolla,Stratagene
R7599	T11665	T11661	punct	", ",Stratagene
R7600	T11666	T11661	npadvmod	California,Stratagene
R7601	T11667	T11661	punct	", ",Stratagene
R7602	T11668	T11669	compound	United,States
R7603	T11669	T11661	npadvmod	States,Stratagene
R7604	T11670	T11661	punct	),Stratagene
R7605	T11671	T11654	punct	", ",built
R7606	T11672	T11673	advmod	then,digested
R7607	T11673	T11654	conj	digested,built
R7608	T11674	T11673	prep	with,digested
R7609	T11675	T11674	pobj	XhoI,with
R7610	T11676	T11673	cc	and,digested
R7611	T11677	T11673	conj	subcloned,digested
R7612	T11678	T11677	prep	into,subcloned
R7613	T11679	T11678	pobj	pSV1,into
R7614	T11680	T11679	punct	", ",pSV1
R7615	T11681	T11682	det	the,vector
R7616	T11682	T11679	appos	vector,pSV1
R7617	T11683	T11682	acl	used,vector
R7618	T11684	T11683	prep	for,used
R7619	T11685	T11686	amod	homologous,recombination
R7620	T11686	T11684	pobj	recombination,for
R7621	T11687	T11688	punct	(,Yang
R7622	T11688	T11683	meta	Yang,used
R7623	T11689	T11688	nmod	et,Yang
R7624	T11690	T11688	nmod	al.,Yang
R7625	T11691	T11688	nummod	1997,Yang
R7626	T11692	T11688	punct	),Yang
R7627	T11693	T11654	punct	.,built
R7628	T11695	T11696	nmod	Southern,blotting
R7629	T11696	T11697	nmod	blotting,analysis
R7630	T11697	T11704	nsubj	analysis,confirmed
R7631	T11698	T11696	punct	", ",blotting
R7632	T11699	T11696	conj	PCR,blotting
R7633	T11700	T11699	punct	", ",PCR
R7634	T11701	T11699	cc	and,PCR
R7635	T11702	T11703	compound	DNA,sequence
R7636	T11703	T11699	conj	sequence,PCR
R7637	T11705	T11706	det	the,construct
R7638	T11706	T11709	nsubjpass	construct,made
R7639	T11707	T11706	amod	appropriate,construct
R7640	T11708	T11706	compound	targeting,construct
R7641	T11709	T11704	advcl	made,confirmed
R7642	T11710	T11706	cc	and,construct
R7643	T11711	T11712	compound	BAC,modifications
R7644	T11712	T11706	conj	modifications,construct
R7645	T11713	T11709	auxpass	were,made
R7646	T11714	T11715	punct	(,data
R7647	T11715	T11709	meta	data,made
R7648	T11716	T11715	amod	unpublished,data
R7649	T11717	T11715	punct	),data
R7650	T11718	T11704	punct	.,confirmed
R7651	T11720	T11721	mark	Before,injected
R7652	T11721	T11726	advcl	injected,removed
R7653	T11722	T11723	det	the,BAC
R7654	T11723	T11721	nsubjpass	BAC,injected
R7655	T11724	T11723	amod	modified,BAC
R7656	T11725	T11721	auxpass	was,injected
R7657	T11727	T11728	aux	to,produce
R7658	T11728	T11721	advcl	produce,injected
R7659	T11729	T11730	amod	transgenic,animals
R7660	T11730	T11728	dobj	animals,produce
R7661	T11731	T11726	punct	", ",removed
R7662	T11732	T11733	det	a,site
R7663	T11733	T11726	nsubjpass	site,removed
R7664	T11734	T11733	compound	loxP,site
R7665	T11735	T11733	relcl	present,site
R7666	T11736	T11735	prep	in,present
R7667	T11737	T11738	det	the,vector
R7668	T11738	T11736	pobj	vector,in
R7669	T11739	T11738	compound	BAC,vector
R7670	T11740	T11733	punct	", ",site
R7671	T11741	T11733	appos	pBeloBAC11,site
R7672	T11742	T11726	punct	", ",removed
R7673	T11743	T11726	auxpass	was,removed
R7674	T11744	T11745	aux	to,prevent
R7675	T11745	T11726	advcl	prevent,removed
R7676	T11746	T11747	det	the,addition
R7677	T11747	T11745	dobj	addition,prevent
R7678	T11748	T11747	prep	of,addition
R7679	T11749	T11750	amod	undesired,sites
R7680	T11750	T11748	pobj	sites,of
R7681	T11751	T11750	compound	Cre,sites
R7682	T11752	T11750	compound	target,sites
R7683	T11753	T11747	prep	into,addition
R7684	T11754	T11755	det	the,genome
R7685	T11755	T11753	pobj	genome,into
R7686	T11756	T11726	punct	.,removed
R7687	T11758	T11759	aux	To,do
R7688	T11759	T11760	advcl	do,prepared
R7689	T11761	T11759	dobj	this,do
R7690	T11762	T11760	punct	", ",prepared
R7691	T11763	T11764	compound	BAC,DNA
R7692	T11764	T11760	nsubjpass	DNA,prepared
R7693	T11765	T11760	auxpass	was,prepared
R7694	T11766	T11760	prep	by,prepared
R7695	T11767	T11768	compound	CsCl,separation
R7696	T11768	T11766	pobj	separation,by
R7697	T11769	T11760	punct	", ",prepared
R7698	T11770	T11760	conj	digested,prepared
R7699	T11771	T11770	prep	with,digested
R7700	T11772	T11771	pobj	NotI,with
R7701	T11773	T11774	aux	to,free
R7702	T11774	T11770	advcl	free,digested
R7703	T11775	T11776	det	the,insert
R7704	T11776	T11774	dobj	insert,free
R7705	T11777	T11774	prep	from,free
R7706	T11778	T11779	det	the,vector
R7707	T11779	T11777	pobj	vector,from
R7708	T11780	T11770	punct	", ",digested
R7709	T11781	T11770	cc	and,digested
R7710	T11782	T11783	dep	size,fractionated
R7711	T11783	T11770	conj	fractionated,digested
R7712	T11784	T11783	punct	-,fractionated
R7713	T11785	T11783	prep	over,fractionated
R7714	T11786	T11787	det	a,gradient
R7715	T11787	T11785	pobj	gradient,over
R7716	T11788	T11787	compound	sucrose,gradient
R7717	T11789	T11760	punct	.,prepared
R7718	T11791	T11792	nsubjpass	Aliquots,run
R7719	T11793	T11791	prep	of,Aliquots
R7720	T11794	T11793	pobj	fractions,of
R7721	T11795	T11792	auxpass	were,run
R7722	T11796	T11792	prep	on,run
R7723	T11797	T11798	det	a,gel
R7724	T11798	T11796	pobj	gel,on
R7725	T11799	T11800	compound	pulse,field
R7726	T11800	T11798	compound	field,gel
R7727	T11801	T11800	punct	-,field
R7728	T11802	T11792	cc	and,run
R7729	T11803	T11804	dep	Southern,blotted
R7730	T11804	T11792	conj	blotted,run
R7731	T11805	T11804	advcl	using,blotted
R7732	T11806	T11807	nmod	vector,DNA
R7733	T11807	T11805	dobj	DNA,using
R7734	T11808	T11806	punct	-,vector
R7735	T11809	T11806	amod	specific,vector
R7736	T11810	T11805	prep	as,using
R7737	T11811	T11812	det	a,probe
R7738	T11812	T11810	pobj	probe,as
R7739	T11813	T11792	punct	.,run
R7740	T11815	T11816	nsubjpass	Fractions,dialyzed
R7741	T11817	T11815	acl	containing,Fractions
R7742	T11818	T11819	amod	unsheared,insert
R7743	T11819	T11817	dobj	insert,containing
R7744	T11820	T11819	cc	and,insert
R7745	T11821	T11822	advmod	almost,DNA
R7746	T11822	T11819	conj	DNA,insert
R7747	T11823	T11822	det	no,DNA
R7748	T11824	T11822	amod	detectable,DNA
R7749	T11825	T11822	compound	vector,DNA
R7750	T11826	T11816	auxpass	were,dialyzed
R7751	T11827	T11816	prep	in,dialyzed
R7752	T11828	T11829	compound	microinjection,buffer
R7753	T11829	T11827	pobj	buffer,in
R7754	T11830	T11831	punct	(,Tris
R7755	T11831	T11829	parataxis	Tris,buffer
R7756	T11832	T11833	nummod	10,mM
R7757	T11833	T11831	compound	mM,Tris
R7758	T11834	T11831	punct	[,Tris
R7759	T11835	T11831	npadvmod	pH,Tris
R7760	T11836	T11835	nummod	7.4,pH
R7761	T11837	T11831	punct	],Tris
R7762	T11838	T11831	prep	with,Tris
R7763	T11839	T11840	nummod	0.15,mM
R7764	T11840	T11841	compound	mM,EDTA
R7765	T11841	T11838	pobj	EDTA,with
R7766	T11842	T11841	punct	[,EDTA
R7767	T11843	T11841	npadvmod	pH,EDTA
R7768	T11844	T11843	nummod	8.0,pH
R7769	T11845	T11841	punct	],EDTA
R7770	T11846	T11831	punct	),Tris
R7771	T11847	T11816	advcl	using,dialyzed
R7772	T11848	T11849	nmod	Centriprep,concentrators
R7773	T11849	T11847	dobj	concentrators,using
R7774	T11850	T11848	punct	-,Centriprep
R7775	T11851	T11848	nummod	30,Centriprep
R7776	T11852	T11853	punct	(,Millipore
R7777	T11853	T11849	parataxis	Millipore,concentrators
R7778	T11854	T11853	punct	", ",Millipore
R7779	T11855	T11853	npadvmod	Billerica,Millipore
R7780	T11856	T11853	punct	", ",Millipore
R7781	T11857	T11853	npadvmod	Massachusetts,Millipore
R7782	T11858	T11853	punct	", ",Millipore
R7783	T11859	T11860	compound	United,States
R7784	T11860	T11853	npadvmod	States,Millipore
R7785	T11861	T11853	punct	),Millipore
R7786	T11862	T11816	punct	.,dialyzed
R7787	T11864	T11865	det	This,DNA
R7788	T11865	T11868	nsubj	DNA,adjusted
R7789	T11866	T11865	amod	purified,DNA
R7790	T11867	T11865	compound	insert,DNA
R7791	T11869	T11868	aux	was,adjusted
R7792	T11870	T11868	prep	to,adjusted
R7793	T11871	T11872	nummod	1,ng
R7794	T11872	T11870	pobj	ng,to
R7795	T11873	T11874	punct	/,μl
R7796	T11874	T11872	prep	μl,ng
R7797	T11875	T11868	cc	and,adjusted
R7798	T11876	T11868	conj	injected,adjusted
R7799	T11877	T11876	prep	into,injected
R7800	T11878	T11879	det	the,pronucleus
R7801	T11879	T11877	pobj	pronucleus,into
R7802	T11880	T11879	prep	of,pronucleus
R7803	T11881	T11882	amod	fertilized,eggs
R7804	T11882	T11880	pobj	eggs,of
R7805	T11883	T11882	prep	from,eggs
R7806	T11884	T11885	compound	FVB,N
R7807	T11885	T11887	compound	N,mice
R7808	T11886	T11885	punct	/,N
R7809	T11887	T11883	pobj	mice,from
R7810	T11888	T11868	agent	by,adjusted
R7811	T11889	T11890	det	the,Facility
R7812	T11890	T11888	pobj	Facility,by
R7813	T11891	T11890	compound	Stanford,Facility
R7814	T11892	T11890	compound	Transgenic,Facility
R7815	T11893	T11868	punct	.,adjusted
R7816	T11895	T11896	amod	Transgenic,mice
R7817	T11896	T11898	nsubjpass	mice,identified
R7818	T11897	T11896	compound	founder,mice
R7819	T11899	T11898	auxpass	were,identified
R7820	T11900	T11898	prep	by,identified
R7821	T11901	T11900	pobj	PCR,by
R7822	T11902	T11901	acl	using,PCR
R7823	T11903	T11904	npadvmod	Cre,specific
R7824	T11904	T11906	amod	specific,GCCTGCATTACCGGTCGATGCAACGA
R7825	T11905	T11904	punct	-,specific
R7826	T11906	T11902	dobj	GCCTGCATTACCGGTCGATGCAACGA,using
R7827	T11907	T11906	nmod	primers,GCCTGCATTACCGGTCGATGCAACGA
R7828	T11908	T11906	nummod	5,GCCTGCATTACCGGTCGATGCAACGA
R7829	T11909	T11908	punct	′,5
R7830	T11910	T11906	punct	-,GCCTGCATTACCGGTCGATGCAACGA
R7831	T11911	T11906	punct	-,GCCTGCATTACCGGTCGATGCAACGA
R7832	T11912	T11906	nummod	3,GCCTGCATTACCGGTCGATGCAACGA
R7833	T11913	T11906	punct	′,GCCTGCATTACCGGTCGATGCAACGA
R7834	T11914	T11906	cc	and,GCCTGCATTACCGGTCGATGCAACGA
R7835	T11915	T11916	nummod	5,GTGGCAGATGGCGCGGCAACACCATT
R7836	T11916	T11906	conj	GTGGCAGATGGCGCGGCAACACCATT,GCCTGCATTACCGGTCGATGCAACGA
R7837	T11917	T11915	punct	′,5
R7838	T11918	T11916	punct	-,GTGGCAGATGGCGCGGCAACACCATT
R7839	T11919	T11916	punct	-,GTGGCAGATGGCGCGGCAACACCATT
R7840	T11920	T11916	nummod	3,GTGGCAGATGGCGCGGCAACACCATT
R7841	T11921	T11916	punct	′,GTGGCAGATGGCGCGGCAACACCATT
R7842	T11922	T11906	punct	", ",GCCTGCATTACCGGTCGATGCAACGA
R7843	T11923	T11924	dep	which,amplify
R7844	T11924	T11906	relcl	amplify,GCCTGCATTACCGGTCGATGCAACGA
R7845	T11925	T11926	det	a,product
R7846	T11926	T11924	dobj	product,amplify
R7847	T11927	T11928	nummod	725,bp
R7848	T11928	T11926	compound	bp,product
R7849	T11929	T11928	punct	-,bp
R7850	T11930	T11898	punct	", ",identified
R7851	T11931	T11898	cc	and,identified
R7852	T11932	T11933	auxpass	were,assessed
R7853	T11933	T11898	conj	assessed,identified
R7854	T11934	T11933	prep	for,assessed
R7855	T11935	T11934	pobj	absence,for
R7856	T11936	T11935	prep	of,absence
R7857	T11937	T11938	compound	BAC,vector
R7858	T11938	T11936	pobj	vector,of
R7859	T11939	T11933	advcl	using,assessed
R7860	T11940	T11941	nmod	vector,primers
R7861	T11941	T11939	dobj	primers,using
R7862	T11942	T11940	punct	-,vector
R7863	T11943	T11940	amod	specific,vector
R7864	T11944	T11945	nummod	5,CGGAGTCTGATGCGGTTGCGATG
R7865	T11945	T11941	appos	CGGAGTCTGATGCGGTTGCGATG,primers
R7866	T11946	T11944	punct	′,5
R7867	T11947	T11945	punct	-,CGGAGTCTGATGCGGTTGCGATG
R7868	T11948	T11945	punct	-,CGGAGTCTGATGCGGTTGCGATG
R7869	T11949	T11945	nummod	3,CGGAGTCTGATGCGGTTGCGATG
R7870	T11950	T11945	punct	′,CGGAGTCTGATGCGGTTGCGATG
R7871	T11951	T11945	cc	and,CGGAGTCTGATGCGGTTGCGATG
R7872	T11952	T11953	nummod	5,AGTGCTGTTCCCTGGTGCTTCCTC
R7873	T11953	T11945	conj	AGTGCTGTTCCCTGGTGCTTCCTC,CGGAGTCTGATGCGGTTGCGATG
R7874	T11954	T11952	punct	′,5
R7875	T11955	T11953	punct	-,AGTGCTGTTCCCTGGTGCTTCCTC
R7876	T11956	T11953	punct	-,AGTGCTGTTCCCTGGTGCTTCCTC
R7877	T11957	T11953	nummod	3,AGTGCTGTTCCCTGGTGCTTCCTC
R7878	T11958	T11953	punct	′,AGTGCTGTTCCCTGGTGCTTCCTC
R7879	T11959	T11941	punct	", ",primers
R7880	T11960	T11961	dep	which,amplify
R7881	T11961	T11941	relcl	amplify,primers
R7882	T11962	T11963	det	a,product
R7883	T11963	T11961	dobj	product,amplify
R7884	T11964	T11965	nummod	465,bp
R7885	T11965	T11963	compound	bp,product
R7886	T11966	T11965	punct	-,bp
R7887	T11967	T11898	punct	.,identified
R7888	T11969	T11970	nummod	Three,lines
R7889	T11970	T11971	nsubjpass	lines,established
R7890	T11972	T11970	prep	of,lines
R7891	T11973	T11974	compound	Gdf5,Cre
R7892	T11974	T11976	compound	Cre,mice
R7893	T11975	T11974	punct	-,Cre
R7894	T11976	T11972	pobj	mice,of
R7895	T11977	T11971	auxpass	were,established
R7896	T11978	T11971	cc	and,established
R7897	T11979	T11971	conj	maintained,established
R7898	T11980	T11979	prep	on,maintained
R7899	T11981	T11982	det	the,background
R7900	T11982	T11980	pobj	background,on
R7901	T11983	T11982	compound	FVB,background
R7902	T11984	T11971	punct	.,established
R7903	T11986	T11987	nsubjpass	Matings,used
R7904	T11988	T11986	prep	with,Matings
R7905	T11989	T11990	compound	R26R,Cre
R7906	T11990	T11991	npadvmod	Cre,inducible
R7907	T11991	T11993	amod	inducible,mice
R7908	T11992	T11991	punct	-,inducible
R7909	T11993	T11988	pobj	mice,with
R7910	T11994	T11995	compound	LACZ,reporter
R7911	T11995	T11993	compound	reporter,mice
R7912	T11996	T11997	punct	(,Soriano
R7913	T11997	T11993	meta	Soriano,mice
R7914	T11998	T11997	nummod	1999,Soriano
R7915	T11999	T11997	punct	),Soriano
R7916	T12000	T11987	auxpass	were,used
R7917	T12001	T12002	aux	to,test
R7918	T12002	T11987	advcl	test,used
R7919	T12003	T12002	prep	for,test
R7920	T12004	T12005	compound	Cre,activity
R7921	T12005	T12003	pobj	activity,for
R7922	T12006	T11987	punct	.,used
R7923	T12008	T12009	nsubjpass	Staining,accomplished
R7924	T12010	T12008	prep	for,Staining
R7925	T12011	T12010	pobj	LACZ,for
R7926	T12012	T12011	cc	and,LACZ
R7927	T12013	T12011	conj	HPLAP,LACZ
R7928	T12014	T12008	prep	on,Staining
R7929	T12015	T12016	amod	whole,embryos
R7930	T12016	T12014	pobj	embryos,on
R7931	T12017	T12016	cc	or,embryos
R7932	T12018	T12016	conj	sections,embryos
R7933	T12019	T12018	prep	of,sections
R7934	T12020	T12019	pobj	embryos,of
R7935	T12021	T12009	auxpass	was,accomplished
R7936	T12022	T12009	advcl	following,accomplished
R7937	T12023	T12024	amod	established,protocols
R7938	T12024	T12022	dobj	protocols,following
R7939	T12025	T12026	punct	(,Lobe
R7940	T12026	T12009	meta	Lobe,accomplished
R7941	T12027	T12026	nmod	et,Lobe
R7942	T12028	T12026	nmod	al.,Lobe
R7943	T12029	T12026	nummod	1999,Lobe
R7944	T12030	T12026	punct	),Lobe
R7945	T12031	T12009	punct	.,accomplished
R7946	T12033	T12034	det	The,substrate
R7947	T12034	T12037	nsubj	substrate,is
R7948	T12035	T12036	amod	red,LACZ
R7949	T12036	T12034	compound	LACZ,substrate
R7950	T12038	T12039	punct	(,see
R7951	T12039	T12034	parataxis	see,substrate
R7952	T12040	T12039	dobj	Figure,see
R7953	T12041	T12040	nummod	1E,Figure
R7954	T12042	T12039	punct	),see
R7955	T12043	T12044	nummod	6,galactopyranoside
R7956	T12044	T12037	attr	galactopyranoside,is
R7957	T12045	T12044	punct	-,galactopyranoside
R7958	T12046	T12044	nmod	chloro,galactopyranoside
R7959	T12047	T12044	punct	-,galactopyranoside
R7960	T12048	T12044	nummod	3,galactopyranoside
R7961	T12049	T12044	punct	-,galactopyranoside
R7962	T12050	T12044	compound	indoxyl,galactopyranoside
R7963	T12051	T12044	punct	-,galactopyranoside
R7964	T12052	T12044	compound	beta,galactopyranoside
R7965	T12053	T12044	punct	-,galactopyranoside
R7966	T12054	T12044	compound	D,galactopyranoside
R7967	T12055	T12044	punct	-,galactopyranoside
R7968	T12056	T12057	punct	(,International
R7969	T12057	T12037	parataxis	International,is
R7970	T12058	T12057	compound	Biosynth,International
R7971	T12059	T12057	punct	", ",International
R7972	T12060	T12057	npadvmod	Naperville,International
R7973	T12061	T12057	punct	", ",International
R7974	T12062	T12057	npadvmod	Illinois,International
R7975	T12063	T12057	punct	", ",International
R7976	T12064	T12065	compound	United,States
R7977	T12065	T12057	npadvmod	States,International
R7978	T12066	T12057	punct	),International
R7979	T12067	T12037	punct	.,is
R7980	T12177	T12178	amod	General,characterization
R7981	T12179	T12178	prep	of,characterization
R7982	T12180	T12181	npadvmod	Bmpr1a,mutant
R7983	T12181	T12182	amod	mutant,mice
R7984	T12182	T12179	pobj	mice,of
R7985	T12184	T12185	npadvmod	Bmpr1a,null
R7986	T12185	T12186	amod	null,alleles
R7987	T12186	T12189	nsubjpass	alleles,obtained
R7988	T12187	T12185	cc	and,null
R7989	T12188	T12185	conj	floxed,null
R7990	T12190	T12191	punct	(,Ahn
R7991	T12191	T12186	meta	Ahn,alleles
R7992	T12192	T12191	nmod	et,Ahn
R7993	T12193	T12191	nmod	al.,Ahn
R7994	T12194	T12191	nummod	2001,Ahn
R7995	T12195	T12191	punct	;,Ahn
R7996	T12196	T12191	nmod	Mishina,Ahn
R7997	T12197	T12191	nmod	et,Ahn
R7998	T12198	T12191	nmod	al.,Ahn
R7999	T12199	T12191	nummod	2002,Ahn
R8000	T12200	T12191	punct	),Ahn
R8001	T12201	T12189	auxpass	were,obtained
R8002	T12202	T12189	prep	on,obtained
R8003	T12203	T12204	det	a,background
R8004	T12204	T12202	pobj	background,on
R8005	T12205	T12204	amod	mixed,background
R8006	T12206	T12204	nummod	129,background
R8007	T12207	T12206	cc	and,129
R8008	T12208	T12206	conj	C57BL,129
R8009	T12209	T12208	punct	/,C57BL
R8010	T12210	T12208	nummod	6,C57BL
R8011	T12211	T12189	cc	and,obtained
R8012	T12212	T12189	conj	maintained,obtained
R8013	T12213	T12212	prep	by,maintained
R8014	T12214	T12215	amod	random,breeding
R8015	T12215	T12213	pobj	breeding,by
R8016	T12216	T12189	punct	.,obtained
R8017	T12218	T12219	nsubjpass	Mice,mated
R8018	T12220	T12218	acl	carrying,Mice
R8019	T12221	T12222	det	the,alleles
R8020	T12222	T12220	dobj	alleles,carrying
R8021	T12223	T12222	amod	null,alleles
R8022	T12224	T12223	cc	and,null
R8023	T12225	T12223	conj	floxed,null
R8024	T12226	T12219	auxpass	were,mated
R8025	T12227	T12219	advmod	typically,mated
R8026	T12228	T12219	prep	to,mated
R8027	T12229	T12230	compound	Gdf5,Cre
R8028	T12230	T12232	compound	Cre,mice
R8029	T12231	T12230	punct	-,Cre
R8030	T12232	T12228	pobj	mice,to
R8031	T12233	T12234	mark	as,shown
R8032	T12234	T12219	advcl	shown,mated
R8033	T12235	T12234	prep	in,shown
R8034	T12236	T12235	pobj	Figure,in
R8035	T12237	T12236	nummod	3,Figure
R8036	T12238	T12219	punct	.,mated
R8037	T12240	T12241	det	The,mice
R8038	T12241	T12243	nsubj	mice,are
R8039	T12242	T12241	amod	resulting,mice
R8040	T12244	T12243	prep	on,are
R8041	T12245	T12246	det	a,background
R8042	T12246	T12244	pobj	background,on
R8043	T12247	T12246	amod	mixed,background
R8044	T12248	T12246	nummod	129,background
R8045	T12249	T12248	punct	;,129
R8046	T12250	T12248	appos	C57Bl,129
R8047	T12251	T12250	punct	/,C57Bl
R8048	T12252	T12250	nummod	6,C57Bl
R8049	T12253	T12248	punct	;,129
R8050	T12254	T12255	compound	FVB,N
R8051	T12255	T12248	appos	N,129
R8052	T12256	T12255	punct	/,N
R8053	T12257	T12243	punct	", ",are
R8054	T12258	T12259	mark	with,generated
R8055	T12259	T12243	advcl	generated,are
R8056	T12260	T12261	preconj	both,controls
R8057	T12261	T12259	nsubj	controls,generated
R8058	T12262	T12261	cc	and,controls
R8059	T12263	T12264	compound	mutant,animals
R8060	T12264	T12261	conj	animals,controls
R8061	T12265	T12259	prep	as,generated
R8062	T12266	T12265	pobj	littermates,as
R8063	T12267	T12266	prep	from,littermates
R8064	T12268	T12269	det	the,matings
R8065	T12269	T12267	pobj	matings,from
R8066	T12270	T12269	amod	same,matings
R8067	T12271	T12243	punct	.,are
R8068	T12273	T12274	amod	Whole,mount
R8069	T12274	T12276	nmod	mount,preparations
R8070	T12275	T12274	punct	-,mount
R8071	T12276	T12278	nsubjpass	preparations,made
R8072	T12277	T12276	amod	skeletal,preparations
R8073	T12279	T12278	auxpass	were,made
R8074	T12280	T12278	prep	from,made
R8075	T12281	T12282	quantmod	34,36
R8076	T12282	T12285	nummod	36,d
R8077	T12283	T12282	punct	-,36
R8078	T12284	T12282	quantmod	to,36
R8079	T12285	T12287	npadvmod	d,old
R8080	T12286	T12285	punct	-,d
R8081	T12287	T12289	amod	old,mice
R8082	T12288	T12287	punct	-,old
R8083	T12289	T12280	pobj	mice,from
R8084	T12290	T12291	punct	(,Lufkin
R8085	T12291	T12278	meta	Lufkin,made
R8086	T12292	T12291	nmod	et,Lufkin
R8087	T12293	T12291	nmod	al.,Lufkin
R8088	T12294	T12291	nummod	1992,Lufkin
R8089	T12295	T12291	punct	),Lufkin
R8090	T12296	T12278	punct	.,made
R8091	T12298	T12299	nsubjpass	Pairs,removed
R8092	T12300	T12298	prep	of,Pairs
R8093	T12301	T12300	pobj	ears,of
R8094	T12302	T12298	prep	from,Pairs
R8095	T12303	T12304	amod	euthanized,animals
R8096	T12304	T12302	pobj	animals,from
R8097	T12305	T12306	nummod	6,mo
R8098	T12306	T12308	npadvmod	mo,old
R8099	T12307	T12306	punct	-,mo
R8100	T12308	T12304	amod	old,animals
R8101	T12309	T12308	punct	-,old
R8102	T12310	T12299	auxpass	were,removed
R8103	T12311	T12299	punct	", ",removed
R8104	T12312	T12299	conj	pinned,removed
R8105	T12313	T12312	punct	", ",pinned
R8106	T12314	T12312	conj	photographed,pinned
R8107	T12315	T12314	punct	", ",photographed
R8108	T12316	T12314	conj	projected,photographed
R8109	T12317	T12316	punct	", ",projected
R8110	T12318	T12316	cc	and,projected
R8111	T12319	T12316	conj	measured,projected
R8112	T12320	T12319	prep	from,measured
R8113	T12321	T12322	det	the,base
R8114	T12322	T12320	pobj	base,from
R8115	T12323	T12322	prep	of,base
R8116	T12324	T12325	det	the,curve
R8117	T12325	T12323	pobj	curve,of
R8118	T12326	T12325	acl	formed,curve
R8119	T12327	T12326	prep	between,formed
R8120	T12328	T12329	det	the,tragus
R8121	T12329	T12327	pobj	tragus,between
R8122	T12330	T12329	cc	and,tragus
R8123	T12331	T12329	conj	antitragus,tragus
R8124	T12332	T12320	prep	to,from
R8125	T12333	T12334	det	the,point
R8126	T12334	T12332	pobj	point,to
R8127	T12335	T12334	amod	farthest,point
R8128	T12336	T12334	prep	at,point
R8129	T12337	T12338	det	the,edge
R8130	T12338	T12336	pobj	edge,at
R8131	T12339	T12338	prep	of,edge
R8132	T12340	T12341	det	the,pinnae
R8133	T12341	T12339	pobj	pinnae,of
R8134	T12342	T12299	punct	.,removed
R8135	T12344	T12345	compound	Grasping,ability
R8136	T12345	T12346	nsubjpass	ability,measured
R8137	T12347	T12345	prep	in,ability
R8138	T12348	T12349	nummod	6,mo
R8139	T12349	T12351	npadvmod	mo,old
R8140	T12350	T12349	punct	-,mo
R8141	T12351	T12353	amod	old,mice
R8142	T12352	T12351	punct	-,old
R8143	T12353	T12347	pobj	mice,in
R8144	T12354	T12346	auxpass	was,measured
R8145	T12355	T12346	prep	by,measured
R8146	T12356	T12355	pcomp	placing,by
R8147	T12357	T12356	dobj	animals,placing
R8148	T12358	T12356	prep	on,placing
R8149	T12359	T12360	det	a,rod
R8150	T12360	T12358	pobj	rod,on
R8151	T12361	T12360	amod	slender,rod
R8152	T12362	T12356	cc	and,placing
R8153	T12363	T12356	conj	timing,placing
R8154	T12364	T12365	advmod	how,long
R8155	T12365	T12366	advmod	long,remain
R8156	T12366	T12363	ccomp	remain,timing
R8157	T12367	T12366	nsubj	they,remain
R8158	T12368	T12366	aux	could,remain
R8159	T12369	T12366	oprd	suspended,remain
R8160	T12370	T12369	prep	on,suspended
R8161	T12371	T12372	det	the,rod
R8162	T12372	T12370	pobj	rod,on
R8163	T12373	T12363	punct	", ",timing
R8164	T12374	T12363	prep	to,timing
R8165	T12375	T12376	det	a,time
R8166	T12376	T12374	pobj	time,to
R8167	T12377	T12376	amod	maximum,time
R8168	T12378	T12376	acl	allowed,time
R8169	T12379	T12376	prep	of,time
R8170	T12380	T12381	nummod	2,min
R8171	T12381	T12379	pobj	min,of
R8172	T12382	T12346	punct	.,measured
R8173	T12384	T12385	nsubjpass	Data,averaged
R8174	T12386	T12384	prep	from,Data
R8175	T12387	T12388	nummod	five,trials
R8176	T12388	T12386	pobj	trials,from
R8177	T12389	T12388	amod	consecutive,trials
R8178	T12390	T12388	prep	for,trials
R8179	T12391	T12392	det	each,mouse
R8180	T12392	T12390	pobj	mouse,for
R8181	T12393	T12385	auxpass	were,averaged
R8182	T12394	T12385	punct	.,averaged
R8183	T12396	T12397	nmod	Range,assays
R8184	T12397	T12400	nsubjpass	assays,conducted
R8185	T12398	T12396	prep	of,Range
R8186	T12399	T12398	pobj	motion,of
R8187	T12401	T12400	auxpass	were,conducted
R8188	T12402	T12400	prep	on,conducted
R8189	T12403	T12404	det	the,joints
R8190	T12404	T12402	pobj	joints,on
R8191	T12405	T12406	nmod	MT,P1
R8192	T12406	T12404	nmod	P1,joints
R8193	T12407	T12406	punct	/,P1
R8194	T12408	T12406	cc	and,P1
R8195	T12409	T12410	compound	P1,P2
R8196	T12410	T12406	conj	P2,P1
R8197	T12411	T12410	punct	/,P2
R8198	T12412	T12404	prep	of,joints
R8199	T12413	T12414	det	the,digit
R8200	T12414	T12412	pobj	digit,of
R8201	T12415	T12414	amod	second,digit
R8202	T12416	T12414	compound	hindlimb,digit
R8203	T12417	T12404	prep	from,joints
R8204	T12418	T12419	amod	euthanized,animals
R8205	T12419	T12417	pobj	animals,from
R8206	T12420	T12421	nummod	18,wk
R8207	T12421	T12423	npadvmod	wk,old
R8208	T12422	T12421	punct	-,wk
R8209	T12423	T12419	amod	old,animals
R8210	T12424	T12423	punct	-,old
R8211	T12425	T12400	punct	.,conducted
R8212	T12427	T12428	nsubjpass	Forceps,used
R8213	T12429	T12428	auxpass	were,used
R8214	T12430	T12431	aux	to,bend
R8215	T12431	T12428	advcl	bend,used
R8216	T12432	T12433	det	the,joint
R8217	T12433	T12431	dobj	joint,bend
R8218	T12434	T12431	prep	to,bend
R8219	T12435	T12436	poss	its,position
R8220	T12436	T12434	pobj	position,to
R8221	T12437	T12436	amod	natural,position
R8222	T12438	T12436	compound	stopping,position
R8223	T12439	T12428	punct	", ",used
R8224	T12440	T12428	cc	and,used
R8225	T12441	T12442	det	the,angle
R8226	T12442	T12444	nsubjpass	angle,measured
R8227	T12443	T12442	amod	resulting,angle
R8228	T12444	T12428	conj	measured,used
R8229	T12445	T12444	auxpass	was,measured
R8230	T12446	T12444	prep	to,measured
R8231	T12447	T12448	det	the,°
R8232	T12448	T12446	pobj	°,to
R8233	T12449	T12448	amod	nearest,°
R8234	T12450	T12448	nummod	10,°
R8235	T12451	T12444	prep	under,measured
R8236	T12452	T12453	nummod	12.5,magnification
R8237	T12453	T12451	pobj	magnification,under
R8238	T12454	T12452	punct	×,12.5
R8239	T12455	T12444	advcl	using,measured
R8240	T12456	T12457	det	a,reticule
R8241	T12457	T12455	dobj	reticule,using
R8242	T12458	T12459	nummod	360,°
R8243	T12459	T12457	compound	°,reticule
R8244	T12460	T12444	punct	.,measured
R8245	T12462	T12463	nsubj	Analysis,occurred
R8246	T12464	T12462	acl	described,Analysis
R8247	T12465	T12464	prep	in,described
R8248	T12466	T12467	det	this,section
R8249	T12467	T12465	pobj	section,in
R8250	T12468	T12463	prep	on,occurred
R8251	T12469	T12468	pobj	animals,on
R8252	T12470	T12469	acl	lacking,animals
R8253	T12471	T12470	dobj	R26R,lacking
R8254	T12472	T12463	punct	.,occurred
R8255	T12474	T12475	compound	Control,mice
R8256	T12475	T12476	nsubj	mice,included
R8257	T12477	T12478	det	all,genotypes
R8258	T12478	T12476	dobj	genotypes,included
R8259	T12479	T12478	amod	nonmutant,genotypes
R8260	T12480	T12478	acl	generated,genotypes
R8261	T12481	T12480	prep	by,generated
R8262	T12482	T12483	nsubj	Parent,being
R8263	T12483	T12481	pobj	being,by
R8264	T12484	T12482	nummod	1,Parent
R8265	T12485	T12483	acomp	heterozygous,being
R8266	T12486	T12485	prep	for,heterozygous
R8267	T12487	T12488	compound	Gdf5,Cre
R8268	T12488	T12486	pobj	Cre,for
R8269	T12489	T12488	punct	-,Cre
R8270	T12490	T12488	cc	and,Cre
R8271	T12491	T12488	conj	Bmpr1anull,Cre
R8272	T12492	T12483	cc	and,being
R8273	T12493	T12494	nsubj	Parent,being
R8274	T12494	T12483	conj	being,being
R8275	T12495	T12493	nummod	2,Parent
R8276	T12496	T12494	acomp	heterozygous,being
R8277	T12497	T12496	prep	for,heterozygous
R8278	T12498	T12497	pobj	Bmpr1afloxP,for
R8279	T12499	T12500	punct	(,see
R8280	T12500	T12494	parataxis	see,being
R8281	T12501	T12500	dobj	Figure,see
R8282	T12502	T12501	nummod	3,Figure
R8283	T12503	T12500	punct	),see
R8284	T12504	T12476	punct	.,included
R8285	T12506	T12507	det	All,analysis
R8286	T12507	T12509	nsubj	analysis,used
R8287	T12508	T12507	amod	statistical,analysis
R8288	T12510	T12511	det	the,Student
R8289	T12511	T12512	poss	Student,test
R8290	T12512	T12509	dobj	test,used
R8291	T12513	T12511	case	's,Student
R8292	T12514	T12512	compound	t,test
R8293	T12515	T12512	punct	-,test
R8294	T12516	T12512	cc	or,test
R8295	T12517	T12518	poss	Welch,test
R8296	T12518	T12512	conj	test,test
R8297	T12519	T12517	case	's,Welch
R8298	T12520	T12518	compound	t,test
R8299	T12521	T12518	punct	-,test
R8300	T12522	T12509	punct	", ",used
R8301	T12523	T12509	cc	and,used
R8302	T12524	T12525	nsubj	values,are
R8303	T12525	T12509	conj	are,used
R8304	T12526	T12524	acl	listed,values
R8305	T12527	T12525	attr	mean,are
R8306	T12528	T12527	punct	±,mean
R8307	T12529	T12530	amod	standard,error
R8308	T12530	T12527	appos	error,mean
R8309	T12531	T12530	prep	of,error
R8310	T12532	T12533	det	the,mean
R8311	T12533	T12531	pobj	mean,of
R8312	T12534	T12525	punct	.,are
R8319	T12651	T12652	compound	Cell,death
R8320	T12653	T12652	cc	and,death
R8321	T12654	T12655	compound	proliferation,assays
R8322	T12655	T12652	conj	assays,death
R8323	T12657	T12658	nsubjpass	Limbs,dissected
R8324	T12659	T12657	prep	from,Limbs
R8325	T12660	T12661	amod	mutant,animals
R8326	T12661	T12659	pobj	animals,from
R8327	T12662	T12660	cc	and,mutant
R8328	T12663	T12660	conj	control,mutant
R8329	T12664	T12657	prep	at,Limbs
R8330	T12665	T12664	pobj	E13.5,at
R8331	T12666	T12665	cc	and,E13.5
R8332	T12667	T12665	conj	E14.5,E13.5
R8333	T12668	T12658	auxpass	were,dissected
R8334	T12669	T12658	cc	and,dissected
R8335	T12670	T12658	conj	frozen,dissected
R8336	T12671	T12670	prep	in,frozen
R8337	T12672	T12671	pobj	OCT,in
R8338	T12673	T12674	punct	(,Finetek
R8339	T12674	T12670	parataxis	Finetek,frozen
R8340	T12675	T12674	compound	Sakura,Finetek
R8341	T12676	T12674	punct	",",Finetek
R8342	T12677	T12674	npadvmod	Torrence,Finetek
R8343	T12678	T12674	punct	", ",Finetek
R8344	T12679	T12674	npadvmod	CA,Finetek
R8345	T12680	T12674	punct	", ",Finetek
R8346	T12681	T12682	compound	United,States
R8347	T12682	T12674	npadvmod	States,Finetek
R8348	T12683	T12674	punct	),Finetek
R8349	T12684	T12658	punct	.,dissected
R8350	T12686	T12687	nsubjpass	Cryosections,assayed
R8351	T12688	T12686	prep	of,Cryosections
R8352	T12689	T12688	pobj	tissue,of
R8353	T12690	T12687	auxpass	were,assayed
R8354	T12691	T12687	prep	by,assayed
R8355	T12692	T12691	pobj	TUNEL,by
R8356	T12693	T12687	advcl	using,assayed
R8357	T12694	T12695	det	the,Kit
R8358	T12695	T12693	dobj	Kit,using
R8359	T12696	T12697	advmod	In,Situ
R8360	T12697	T12698	amod	Situ,Detection
R8361	T12698	T12695	compound	Detection,Kit
R8362	T12699	T12700	compound	Cell,Death
R8363	T12700	T12698	compound	Death,Detection
R8364	T12701	T12695	punct	", ",Kit
R8365	T12702	T12695	npadvmod	Fluorescein,Kit
R8366	T12703	T12702	punct	(,Fluorescein
R8367	T12704	T12702	npadvmod	Roche,Fluorescein
R8368	T12705	T12702	punct	", ",Fluorescein
R8369	T12706	T12702	npadvmod	Basel,Fluorescein
R8370	T12707	T12702	punct	", ",Fluorescein
R8371	T12708	T12702	npadvmod	Switzerland,Fluorescein
R8372	T12709	T12702	punct	),Fluorescein
R8373	T12710	T12687	punct	.,assayed
R8374	T12712	T12713	prep	Following,washed
R8375	T12714	T12712	pobj	TUNEL,Following
R8376	T12715	T12713	punct	", ",washed
R8377	T12716	T12713	nsubjpass	slides,washed
R8378	T12717	T12713	auxpass	were,washed
R8379	T12718	T12713	prep	in,washed
R8380	T12719	T12718	pobj	PBS,in
R8381	T12720	T12713	punct	", ",washed
R8382	T12721	T12713	conj	blocked,washed
R8383	T12722	T12721	prep	with,blocked
R8384	T12723	T12722	pobj	PBS,with
R8385	T12724	T12723	punct	+,PBS
R8386	T12725	T12726	nummod	0.05,%
R8387	T12726	T12727	compound	%,Tween
R8388	T12727	T12723	appos	Tween,PBS
R8389	T12728	T12727	punct	-,Tween
R8390	T12729	T12727	nummod	20,Tween
R8391	T12730	T12723	punct	+,PBS
R8392	T12731	T12732	nummod	5,%
R8393	T12732	T12733	compound	%,serum
R8394	T12733	T12723	appos	serum,PBS
R8395	T12734	T12733	compound	goat,serum
R8396	T12735	T12721	punct	", ",blocked
R8397	T12736	T12721	conj	washed,blocked
R8398	T12737	T12736	advmod	again,washed
R8399	T12738	T12736	punct	", ",washed
R8400	T12739	T12736	cc	and,washed
R8401	T12740	T12736	conj	incubated,washed
R8402	T12741	T12740	prep	with,incubated
R8403	T12742	T12743	det	a,dilution
R8404	T12743	T12741	pobj	dilution,with
R8405	T12744	T12743	nummod	1,dilution
R8406	T12745	T12746	punct	:,200
R8407	T12746	T12744	prep	200,1
R8408	T12747	T12743	prep	of,dilution
R8409	T12748	T12749	det	a,antibody
R8410	T12749	T12747	pobj	antibody,of
R8411	T12750	T12749	nmod	rabbit,antibody
R8412	T12751	T12752	amod	anti-phospho-histone,H3
R8413	T12752	T12749	compound	H3,antibody
R8414	T12753	T12752	punct	-,H3
R8415	T12754	T12749	acl	called,antibody
R8416	T12755	T12756	compound	Mitosis,Marker
R8417	T12756	T12754	oprd	Marker,called
R8418	T12757	T12758	punct	(,Biotechnology
R8419	T12758	T12756	parataxis	Biotechnology,Marker
R8420	T12759	T12758	compound	Upstate,Biotechnology
R8421	T12760	T12758	punct	", ",Biotechnology
R8422	T12761	T12762	compound	Lake,Placid
R8423	T12762	T12758	npadvmod	Placid,Biotechnology
R8424	T12763	T12758	punct	", ",Biotechnology
R8425	T12764	T12765	compound	New,York
R8426	T12765	T12758	npadvmod	York,Biotechnology
R8427	T12766	T12758	punct	", ",Biotechnology
R8428	T12767	T12768	compound	United,States
R8429	T12768	T12758	npadvmod	States,Biotechnology
R8430	T12769	T12758	punct	),Biotechnology
R8431	T12770	T12771	aux	to,identify
R8432	T12771	T12740	advcl	identify,incubated
R8433	T12772	T12771	dobj	cells,identify
R8434	T12773	T12772	prep	in,cells
R8435	T12774	T12773	pobj	mitosis,in
R8436	T12775	T12713	punct	.,washed
R8437	T12777	T12778	npadvmod	Cy3,labeled
R8438	T12778	T12780	amod	labeled,antibody
R8439	T12779	T12778	punct	-,labeled
R8440	T12780	T12783	nsubjpass	antibody,used
R8441	T12781	T12780	amod	anti-rabbit,antibody
R8442	T12782	T12780	amod	secondary,antibody
R8443	T12784	T12783	auxpass	was,used
R8444	T12785	T12786	aux	to,detect
R8445	T12786	T12783	advcl	detect,used
R8446	T12787	T12788	det	the,antibody
R8447	T12788	T12786	dobj	antibody,detect
R8448	T12789	T12783	punct	.,used
R8449	T12791	T12792	compound	Cell,nuclei
R8450	T12792	T12793	nsubjpass	nuclei,labeled
R8451	T12794	T12793	auxpass	were,labeled
R8452	T12795	T12793	prep	with,labeled
R8453	T12796	T12795	pobj	DAPI,with
R8454	T12797	T12793	punct	", ",labeled
R8455	T12798	T12793	cc	and,labeled
R8456	T12799	T12800	nsubjpass	slides,mounted
R8457	T12800	T12793	conj	mounted,labeled
R8458	T12801	T12800	auxpass	were,mounted
R8459	T12802	T12800	prep	in,mounted
R8460	T12803	T12802	pobj	Vectamount,in
R8461	T12804	T12805	punct	(,Laboratories
R8462	T12805	T12803	parataxis	Laboratories,Vectamount
R8463	T12806	T12805	compound	Vector,Laboratories
R8464	T12807	T12805	punct	", ",Laboratories
R8465	T12808	T12805	npadvmod	Burlingame,Laboratories
R8466	T12809	T12805	punct	", ",Laboratories
R8467	T12810	T12805	npadvmod	California,Laboratories
R8468	T12811	T12805	punct	", ",Laboratories
R8469	T12812	T12813	compound	United,States
R8470	T12813	T12805	npadvmod	States,Laboratories
R8471	T12814	T12805	punct	),Laboratories
R8472	T12815	T12800	cc	and,mounted
R8473	T12816	T12800	conj	visualized,mounted
R8474	T12817	T12816	prep	at,visualized
R8475	T12818	T12819	nummod	100,magnification
R8476	T12819	T12817	pobj	magnification,at
R8477	T12820	T12818	punct	×,100
R8478	T12821	T12800	punct	.,mounted
R8479	T12823	T12824	det	The,area
R8480	T12824	T12825	nsubjpass	area,measured
R8481	T12826	T12824	prep	of,area
R8482	T12827	T12828	amod	selected,sites
R8483	T12828	T12826	pobj	sites,of
R8484	T12829	T12828	amod	anatomical,sites
R8485	T12830	T12825	auxpass	were,measured
R8486	T12831	T12825	punct	", ",measured
R8487	T12832	T12825	cc	and,measured
R8488	T12833	T12834	det	the,number
R8489	T12834	T12835	nsubjpass	number,counted
R8490	T12835	T12825	conj	counted,measured
R8491	T12836	T12834	prep	of,number
R8492	T12837	T12838	npadvmod	TUNEL,labeled
R8493	T12838	T12840	amod	labeled,fragments
R8494	T12839	T12838	punct	-,labeled
R8495	T12840	T12836	pobj	fragments,of
R8496	T12841	T12840	amod	nuclear,fragments
R8497	T12842	T12834	cc	and,number
R8498	T12843	T12844	det	the,number
R8499	T12844	T12834	conj	number,number
R8500	T12845	T12844	prep	of,number
R8501	T12846	T12847	npadvmod	Cy3,labeled
R8502	T12847	T12849	amod	labeled,nuclei
R8503	T12848	T12847	punct	-,labeled
R8504	T12849	T12845	pobj	nuclei,of
R8505	T12850	T12835	auxpass	were,counted
R8506	T12851	T12835	prep	from,counted
R8507	T12852	T12853	nummod	three,sections
R8508	T12853	T12851	pobj	sections,from
R8509	T12854	T12855	nummod	10,μm
R8510	T12855	T12853	compound	μm,sections
R8511	T12856	T12855	punct	-,μm
R8512	T12857	T12853	acl	spanning,sections
R8513	T12858	T12859	nummod	50,μm
R8514	T12859	T12857	dobj	μm,spanning
R8515	T12860	T12853	punct	", ",sections
R8516	T12861	T12853	prep	from,sections
R8517	T12862	T12863	nummod	three,control
R8518	T12863	T12861	pobj	control,from
R8519	T12864	T12863	cc	and,control
R8520	T12865	T12866	nummod	three,mutant
R8521	T12866	T12867	compound	mutant,animals
R8522	T12867	T12863	conj	animals,control
R8523	T12868	T12835	punct	.,counted
R8524	T12870	T12871	det	The,number
R8525	T12871	T12872	nsubjpass	number,counted
R8526	T12873	T12871	prep	of,number
R8527	T12874	T12875	amod	labeled,cells
R8528	T12875	T12873	pobj	cells,of
R8529	T12876	T12871	prep	in,number
R8530	T12877	T12878	det	the,joints
R8531	T12878	T12876	pobj	joints,in
R8532	T12879	T12880	amod	metacarpal,phalangeal
R8533	T12880	T12878	amod	phalangeal,joints
R8534	T12881	T12880	punct	-,phalangeal
R8535	T12882	T12880	cc	and,phalangeal
R8536	T12883	T12884	amod	metatarsal,phalangeal
R8537	T12884	T12880	conj	phalangeal,phalangeal
R8538	T12885	T12884	punct	-,phalangeal
R8539	T12886	T12872	auxpass	was,counted
R8540	T12887	T12872	prep	in,counted
R8541	T12888	T12889	det	a,rectangle
R8542	T12889	T12887	pobj	rectangle,in
R8543	T12890	T12891	nummod	290,μm
R8544	T12891	T12889	nmod	μm,rectangle
R8545	T12892	T12893	punct	×,μm
R8546	T12893	T12891	prep	μm,μm
R8547	T12894	T12893	nummod	365,μm
R8548	T12895	T12889	acl	placed,rectangle
R8549	T12896	T12895	prep	around,placed
R8550	T12897	T12898	det	the,center
R8551	T12898	T12896	pobj	center,around
R8552	T12899	T12898	prep	of,center
R8553	T12900	T12901	det	the,joint
R8554	T12901	T12899	pobj	joint,of
R8555	T12902	T12872	punct	.,counted
R8556	T12904	T12905	det	The,region
R8557	T12905	T12907	nsubjpass	region,defined
R8558	T12906	T12905	amod	posterior,region
R8559	T12908	T12905	prep	of,region
R8560	T12909	T12910	det	the,digit
R8561	T12910	T12908	pobj	digit,of
R8562	T12911	T12910	amod	fifth,digit
R8563	T12912	T12907	auxpass	was,defined
R8564	T12913	T12907	prep	by,defined
R8565	T12914	T12913	pcomp	drawing,by
R8566	T12915	T12916	det	a,line
R8567	T12916	T12914	dobj	line,drawing
R8568	T12917	T12914	prep	from,drawing
R8569	T12918	T12919	det	the,tip
R8570	T12919	T12917	pobj	tip,from
R8571	T12920	T12919	prep	of,tip
R8572	T12921	T12922	det	the,digit
R8573	T12922	T12920	pobj	digit,of
R8574	T12923	T12914	prep	down,drawing
R8575	T12924	T12925	nummod	2.15,mm
R8576	T12925	T12923	pobj	mm,down
R8577	T12926	T12923	cc	and,down
R8578	T12927	T12923	conj	across,down
R8579	T12928	T12927	prep	to,across
R8580	T12929	T12930	det	the,edge
R8581	T12930	T12928	pobj	edge,to
R8582	T12931	T12930	amod	lateral,edge
R8583	T12932	T12930	prep	of,edge
R8584	T12933	T12934	det	the,tissue
R8585	T12934	T12932	pobj	tissue,of
R8586	T12935	T12907	punct	.,defined
R8587	T12937	T12938	prep	For,was
R8588	T12939	T12940	det	this,analysis
R8589	T12940	T12937	pobj	analysis,For
R8590	T12941	T12938	punct	", ",was
R8591	T12942	T12943	det	the,reporter
R8592	T12943	T12938	nsubj	reporter,was
R8593	T12944	T12945	compound	R26R,Cre
R8594	T12945	T12943	compound	Cre,reporter
R8595	T12946	T12938	neg	not,was
R8596	T12947	T12938	acomp	present,was
R8597	T12948	T12938	punct	.,was
R8598	T13138	T13137	cc	and,Histology
R8599	T13139	T13137	conj	histochemistry,Histology
R8600	T13141	T13142	nsubjpass	Tissue,prepared
R8601	T13143	T13141	prep	from,Tissue
R8602	T13144	T13143	pobj	animals,from
R8603	T13145	T13144	acl	ranging,animals
R8604	T13146	T13145	prep	from,ranging
R8605	T13147	T13148	compound	stages,E14.5
R8606	T13148	T13146	pobj	E14.5,from
R8607	T13149	T13146	prep	to,from
R8608	T13150	T13149	pobj	P14,to
R8609	T13151	T13142	auxpass	was,prepared
R8610	T13152	T13142	prep	for,prepared
R8611	T13153	T13152	pobj	analysis,for
R8612	T13154	T13142	prep	by,prepared
R8613	T13155	T13154	pcomp	fixing,by
R8614	T13156	T13155	prep	in,fixing
R8615	T13157	T13158	nummod	4,%
R8616	T13158	T13159	compound	%,paraformaldehyde
R8617	T13159	T13156	pobj	paraformaldehyde,in
R8618	T13160	T13161	punct	(,PFA
R8619	T13161	T13159	parataxis	PFA,paraformaldehyde
R8620	T13162	T13161	punct	),PFA
R8621	T13163	T13159	prep	in,paraformaldehyde
R8622	T13164	T13163	pobj	PBS,in
R8623	T13165	T13155	prep	for,fixing
R8624	T13166	T13167	nummod	45,min
R8625	T13167	T13165	pobj	min,for
R8626	T13168	T13167	prep	to,min
R8627	T13169	T13170	nummod	4,h
R8628	T13170	T13168	pobj	h,to
R8629	T13171	T13167	prep	depending,min
R8630	T13172	T13171	prep	on,depending
R8631	T13173	T13174	det	the,stage
R8632	T13174	T13172	pobj	stage,on
R8633	T13175	T13155	punct	;,fixing
R8634	T13176	T13155	conj	washing,fixing
R8635	T13177	T13178	nummod	three,times
R8636	T13178	T13176	npadvmod	times,washing
R8637	T13179	T13176	prep	in,washing
R8638	T13180	T13179	pobj	PBS,in
R8639	T13181	T13176	punct	", ",washing
R8640	T13182	T13176	conj	once,washing
R8641	T13183	T13182	prep	in,once
R8642	T13184	T13183	pobj	PBS,in
R8643	T13185	T13184	punct	+,PBS
R8644	T13186	T13187	nummod	15,%
R8645	T13187	T13188	compound	%,sucrose
R8646	T13188	T13184	appos	sucrose,PBS
R8647	T13189	T13182	prep	for,once
R8648	T13190	T13191	nummod	1,h
R8649	T13191	T13189	pobj	h,for
R8650	T13192	T13182	punct	", ",once
R8651	T13193	T13182	cc	and,once
R8652	T13194	T13182	conj	once,once
R8653	T13195	T13194	prep	in,once
R8654	T13196	T13195	pobj	PBS,in
R8655	T13197	T13196	punct	+,PBS
R8656	T13198	T13199	nummod	30,%
R8657	T13199	T13200	compound	%,sucrose
R8658	T13200	T13196	appos	sucrose,PBS
R8659	T13201	T13194	prep	for,once
R8660	T13202	T13203	nummod	2,h
R8661	T13203	T13201	pobj	h,for
R8662	T13204	T13203	prep	to,h
R8663	T13205	T13204	pobj	overnight,to
R8664	T13206	T13203	prep	depending,h
R8665	T13207	T13206	prep	on,depending
R8666	T13208	T13209	det	the,stage
R8667	T13209	T13207	pobj	stage,on
R8668	T13210	T13176	punct	;,washing
R8669	T13211	T13176	cc	and,washing
R8670	T13212	T13213	advmod	then,freezing
R8671	T13213	T13176	conj	freezing,washing
R8672	T13214	T13213	prep	in,freezing
R8673	T13215	T13214	pobj	OCT,in
R8674	T13216	T13142	punct	.,prepared
R8675	T13218	T13219	nsubjpass	Tissue,processed
R8676	T13220	T13218	prep	from,Tissue
R8677	T13221	T13220	pobj	animals,from
R8678	T13222	T13221	acl	aged,animals
R8679	T13223	T13224	nummod	7,wk
R8680	T13224	T13222	npadvmod	wk,aged
R8681	T13225	T13224	prep	to,wk
R8682	T13226	T13227	nummod	9,mo
R8683	T13227	T13225	pobj	mo,to
R8684	T13228	T13219	auxpass	was,processed
R8685	T13229	T13219	advmod	similarly,processed
R8686	T13230	T13229	prep	to,similarly
R8687	T13231	T13232	amod	earlier,stages
R8688	T13232	T13230	pobj	stages,to
R8689	T13233	T13219	prep	except,processed
R8690	T13234	T13235	mark	that,decalcified
R8691	T13235	T13233	pcomp	decalcified,except
R8692	T13236	T13235	nsubjpass	it,decalcified
R8693	T13237	T13235	auxpass	was,decalcified
R8694	T13238	T13235	prep	in,decalcified
R8695	T13239	T13240	nummod	0.5,M
R8696	T13240	T13241	compound	M,EDTA
R8697	T13241	T13238	pobj	EDTA,in
R8698	T13242	T13241	punct	(,EDTA
R8699	T13243	T13241	npadvmod	pH,EDTA
R8700	T13244	T13243	nummod	7.4,pH
R8701	T13245	T13241	punct	),EDTA
R8702	T13246	T13235	prep	for,decalcified
R8703	T13247	T13248	nummod	4,d
R8704	T13248	T13246	pobj	d,for
R8705	T13249	T13250	amod	prior,to
R8706	T13250	T13235	prep	to,decalcified
R8707	T13251	T13250	pcomp	incubating,to
R8708	T13252	T13251	prep	in,incubating
R8709	T13253	T13252	pobj	sucrose,in
R8710	T13254	T13219	punct	.,processed
R8711	T13256	T13257	det	All,solutions
R8712	T13257	T13258	nsubjpass	solutions,prechilled
R8713	T13259	T13258	auxpass	were,prechilled
R8714	T13260	T13258	cc	and,prechilled
R8715	T13261	T13258	conj	used,prechilled
R8716	T13262	T13261	prep	at,used
R8717	T13263	T13264	nummod	4,°C
R8718	T13264	T13262	pobj	°C,at
R8719	T13265	T13261	prep	with,used
R8720	T13266	T13265	pobj	agitation,with
R8721	T13267	T13258	punct	", ",prechilled
R8722	T13268	T13258	cc	and,prechilled
R8723	T13269	T13270	nsubjpass	skin,lacerated
R8724	T13270	T13258	conj	lacerated,prechilled
R8725	T13271	T13269	prep	from,skin
R8726	T13272	T13271	pobj	tissues,from
R8727	T13273	T13272	prep	of,tissues
R8728	T13274	T13275	nmod	P0,mice
R8729	T13275	T13273	pobj	mice,of
R8730	T13276	T13274	cc	or,P0
R8731	T13277	T13274	conj	older,P0
R8732	T13278	T13270	auxpass	was,lacerated
R8733	T13279	T13270	cc	or,lacerated
R8734	T13280	T13270	conj	removed,lacerated
R8735	T13281	T13282	amod	prior,to
R8736	T13282	T13280	prep	to,removed
R8737	T13283	T13282	pobj	processing,to
R8738	T13284	T13270	punct	.,lacerated
R8739	T13286	T13287	nsubjpass	Tissue,cryosectioned
R8740	T13288	T13287	auxpass	was,cryosectioned
R8741	T13289	T13287	advmod	then,cryosectioned
R8742	T13290	T13287	prep	at,cryosectioned
R8743	T13291	T13292	nummod	12,μm
R8744	T13292	T13290	pobj	μm,at
R8745	T13293	T13287	cc	and,cryosectioned
R8746	T13294	T13287	conj	processed,cryosectioned
R8747	T13295	T13287	punct	.,cryosectioned
R8748	T13297	T13298	nsubjpass	Staining,carried
R8749	T13299	T13297	prep	of,Staining
R8750	T13300	T13299	pobj	sections,of
R8751	T13301	T13297	prep	with,Staining
R8752	T13302	T13303	compound	Safranin,O
R8753	T13303	T13301	pobj	O,with
R8754	T13304	T13303	punct	", ",O
R8755	T13305	T13306	amod	Fast,Green
R8756	T13306	T13303	conj	Green,O
R8757	T13307	T13306	punct	", ",Green
R8758	T13308	T13306	cc	and,Green
R8759	T13309	T13310	poss	Harris,hematoxylin
R8760	T13310	T13306	conj	hematoxylin,Green
R8761	T13311	T13309	case	',Harris
R8762	T13312	T13298	auxpass	was,carried
R8763	T13313	T13298	prt	out,carried
R8764	T13314	T13298	advcl	using,carried
R8765	T13315	T13316	amod	standard,procedures
R8766	T13316	T13314	dobj	procedures,using
R8767	T13317	T13316	amod	histological,procedures
R8768	T13318	T13298	punct	.,carried
R8769	T13320	T13321	nsubjpass	Detection,performed
R8770	T13322	T13320	prep	of,Detection
R8771	T13323	T13324	compound	LACZ,activity
R8772	T13324	T13322	pobj	activity,of
R8773	T13325	T13320	prep	with,Detection
R8774	T13326	T13327	compound	X,Gal
R8775	T13327	T13325	pobj	Gal,with
R8776	T13328	T13327	punct	-,Gal
R8777	T13329	T13321	auxpass	was,performed
R8778	T13330	T13331	mark	as,described
R8779	T13331	T13321	advcl	described,performed
R8780	T13332	T13333	punct	(,Lobe
R8781	T13333	T13331	meta	Lobe,described
R8782	T13334	T13333	nmod	et,Lobe
R8783	T13335	T13333	nmod	al.,Lobe
R8784	T13336	T13333	nummod	1999,Lobe
R8785	T13337	T13333	punct	),Lobe
R8786	T13338	T13321	cc	and,performed
R8787	T13339	T13340	auxpass	was,followed
R8788	T13340	T13321	conj	followed,performed
R8789	T13341	T13340	agent	by,followed
R8790	T13342	T13341	pcomp	refixing,by
R8791	T13343	T13342	prep	in,refixing
R8792	T13344	T13345	nummod	4,%
R8793	T13345	T13346	compound	%,PFA
R8794	T13346	T13343	pobj	PFA,in
R8795	T13347	T13342	punct	", ",refixing
R8796	T13348	T13342	conj	rinsing,refixing
R8797	T13349	T13348	prep	with,rinsing
R8798	T13350	T13351	amod	deionized,water
R8799	T13351	T13349	pobj	water,with
R8800	T13352	T13348	punct	", ",rinsing
R8801	T13353	T13348	conj	counterstaining,rinsing
R8802	T13354	T13353	prep	with,counterstaining
R8803	T13355	T13356	amod	Nuclear,Red
R8804	T13356	T13354	pobj	Red,with
R8805	T13357	T13356	amod	Fast,Red
R8806	T13358	T13356	punct	(,Red
R8807	T13359	T13360	compound	Vector,Labs
R8808	T13360	T13356	npadvmod	Labs,Red
R8809	T13361	T13356	punct	),Red
R8810	T13362	T13353	punct	", ",counterstaining
R8811	T13363	T13353	conj	rinsing,counterstaining
R8812	T13364	T13363	prep	with,rinsing
R8813	T13365	T13364	pobj	water,with
R8814	T13366	T13363	advmod	again,rinsing
R8815	T13367	T13363	punct	", ",rinsing
R8816	T13368	T13363	cc	and,rinsing
R8817	T13369	T13370	advmod	then,mounting
R8818	T13370	T13363	conj	mounting,rinsing
R8819	T13371	T13370	prep	in,mounting
R8820	T13372	T13371	pobj	Aquamount,in
R8821	T13373	T13374	punct	(,Labs
R8822	T13374	T13372	parataxis	Labs,Aquamount
R8823	T13375	T13374	compound	Lerner,Labs
R8824	T13376	T13374	punct	", ",Labs
R8825	T13377	T13374	npadvmod	Pittsburgh,Labs
R8826	T13378	T13374	punct	", ",Labs
R8827	T13379	T13374	npadvmod	Pennsylvania,Labs
R8828	T13380	T13374	punct	", ",Labs
R8829	T13381	T13382	compound	United,States
R8830	T13382	T13374	npadvmod	States,Labs
R8831	T13383	T13374	punct	),Labs
R8832	T13384	T13321	punct	.,performed
R8833	T13386	T13387	nmod	RNA,hybridization
R8834	T13387	T13390	nsubjpass	hybridization,performed
R8835	T13388	T13389	advmod	in,situ
R8836	T13389	T13387	amod	situ,hybridization
R8837	T13391	T13390	auxpass	was,performed
R8838	T13392	T13393	mark	as,described
R8839	T13393	T13390	advcl	described,performed
R8840	T13394	T13395	punct	(,Storm
R8841	T13395	T13393	meta	Storm,described
R8842	T13396	T13395	cc	and,Storm
R8843	T13397	T13395	conj	Kingsley,Storm
R8844	T13398	T13397	nummod	1996,Kingsley
R8845	T13399	T13397	punct	),Kingsley
R8846	T13400	T13390	punct	", ",performed
R8847	T13401	T13390	prep	with,performed
R8848	T13402	T13403	det	the,modifications
R8849	T13403	T13401	pobj	modifications,with
R8850	T13404	T13403	amod	following,modifications
R8851	T13405	T13390	punct	: ,performed
R8852	T13406	T13407	punct	(,1
R8853	T13407	T13408	meta	1,incubated
R8854	T13408	T13390	conj	incubated,performed
R8855	T13409	T13407	punct	),1
R8856	T13410	T13411	amod	Prior,to
R8857	T13411	T13408	prep	to,incubated
R8858	T13412	T13413	det	the,step
R8859	T13413	T13411	pobj	step,to
R8860	T13414	T13413	compound	acetylation,step
R8861	T13415	T13408	punct	", ",incubated
R8862	T13416	T13408	nsubjpass	sections,incubated
R8863	T13417	T13408	auxpass	were,incubated
R8864	T13418	T13408	prep	with,incubated
R8865	T13419	T13420	compound	10,20
R8866	T13420	T13422	nummod	20,μg
R8867	T13421	T13420	punct	–,20
R8868	T13422	T13423	nmod	μg,K
R8869	T13423	T13418	pobj	K,with
R8870	T13424	T13425	punct	/,ml
R8871	T13425	T13422	prep	ml,μg
R8872	T13426	T13423	compound	proteinase,K
R8873	T13427	T13408	prep	for,incubated
R8874	T13428	T13429	nummod	30,s
R8875	T13429	T13427	pobj	s,for
R8876	T13430	T13429	prep	to,s
R8877	T13431	T13432	nummod	7,min
R8878	T13432	T13430	pobj	min,to
R8879	T13433	T13408	prep	at,incubated
R8880	T13434	T13435	compound	room,temperature
R8881	T13435	T13433	pobj	temperature,at
R8882	T13436	T13435	punct	(,temperature
R8883	T13437	T13435	prep	depending,temperature
R8884	T13438	T13437	prep	on,depending
R8885	T13439	T13440	det	the,stage
R8886	T13440	T13438	pobj	stage,on
R8887	T13441	T13440	amod	developmental,stage
R8888	T13442	T13435	punct	),temperature
R8889	T13443	T13408	punct	", ",incubated
R8890	T13444	T13408	advcl	followed,incubated
R8891	T13445	T13444	agent	by,followed
R8892	T13446	T13445	pcomp	refixing,by
R8893	T13447	T13446	prep	in,refixing
R8894	T13448	T13449	nummod	4,%
R8895	T13449	T13450	compound	%,PFA
R8896	T13450	T13447	pobj	PFA,in
R8897	T13451	T13446	cc	and,refixing
R8898	T13452	T13446	conj	washing,refixing
R8899	T13453	T13454	nummod	three,times
R8900	T13454	T13452	npadvmod	times,washing
R8901	T13455	T13452	prep	in,washing
R8902	T13456	T13455	pobj	PBS,in
R8903	T13457	T13408	punct	;,incubated
R8904	T13458	T13459	punct	(,2
R8905	T13459	T13460	meta	2,skipped
R8906	T13460	T13408	conj	skipped,incubated
R8907	T13461	T13459	punct	),2
R8908	T13462	T13463	compound	prehybridization,step
R8909	T13463	T13460	nsubjpass	step,skipped
R8910	T13464	T13460	auxpass	was,skipped
R8911	T13465	T13460	punct	", ",skipped
R8912	T13466	T13460	cc	and,skipped
R8913	T13467	T13468	punct	(,3
R8914	T13468	T13469	meta	3,used
R8915	T13469	T13460	conj	used,skipped
R8916	T13470	T13468	punct	),3
R8917	T13471	T13472	amod	embryonic,tissue
R8918	T13472	T13473	compound	tissue,sections
R8919	T13473	T13469	nsubj	sections,used
R8920	T13474	T13475	det	a,mix
R8921	T13475	T13469	dobj	mix,used
R8922	T13476	T13475	amod	different,mix
R8923	T13477	T13475	compound	color,mix
R8924	T13478	T13475	compound	development,mix
R8925	T13479	T13480	punct	(,Thut
R8926	T13480	T13469	meta	Thut,used
R8927	T13481	T13480	nmod	et,Thut
R8928	T13482	T13480	nmod	al.,Thut
R8929	T13483	T13480	nummod	2001,Thut
R8930	T13484	T13480	punct	),Thut
R8931	T13485	T13469	punct	.,used
R8932	T13487	T13488	nsubjpass	Probes,published
R8933	T13489	T13487	prep	for,Probes
R8934	T13490	T13491	det	the,genes
R8935	T13491	T13489	pobj	genes,for
R8936	T13492	T13491	amod	following,genes
R8937	T13493	T13488	aux	have,published
R8938	T13494	T13488	auxpass	been,published
R8939	T13495	T13488	advmod	previously,published
R8940	T13496	T13488	punct	: ,published
R8941	T13497	T13488	dobj	Bmpr1a,published
R8942	T13498	T13499	punct	(,Mishina
R8943	T13499	T13497	meta	Mishina,Bmpr1a
R8944	T13500	T13499	nmod	et,Mishina
R8945	T13501	T13499	nmod	al.,Mishina
R8946	T13502	T13499	nummod	1995,Mishina
R8947	T13503	T13499	punct	),Mishina
R8948	T13504	T13497	punct	", ",Bmpr1a
R8949	T13505	T13497	conj	Col2a1,Bmpr1a
R8950	T13506	T13507	punct	(,Metsaranta
R8951	T13507	T13505	meta	Metsaranta,Col2a1
R8952	T13508	T13507	nmod	et,Metsaranta
R8953	T13509	T13507	nmod	al.,Metsaranta
R8954	T13510	T13507	nummod	1991,Metsaranta
R8955	T13511	T13507	punct	),Metsaranta
R8956	T13512	T13505	punct	", ",Col2a1
R8957	T13513	T13505	conj	Col10a1,Col2a1
R8958	T13514	T13515	punct	(,Apte
R8959	T13515	T13513	meta	Apte,Col10a1
R8960	T13516	T13515	nmod	et,Apte
R8961	T13517	T13515	nmod	al.,Apte
R8962	T13518	T13515	nummod	1992,Apte
R8963	T13519	T13515	punct	),Apte
R8964	T13520	T13513	punct	", ",Col10a1
R8965	T13521	T13513	conj	Gdf5,Col10a1
R8966	T13522	T13523	punct	(,Storm
R8967	T13523	T13521	meta	Storm,Gdf5
R8968	T13524	T13523	cc	and,Storm
R8969	T13525	T13523	conj	Kingsley,Storm
R8970	T13526	T13525	nummod	1996,Kingsley
R8971	T13527	T13525	punct	),Kingsley
R8972	T13528	T13521	punct	", ",Gdf5
R8973	T13529	T13521	conj	Osteocalcin,Gdf5
R8974	T13530	T13531	punct	(,Celeste
R8975	T13531	T13529	meta	Celeste,Osteocalcin
R8976	T13532	T13531	nmod	et,Celeste
R8977	T13533	T13531	nmod	al.,Celeste
R8978	T13534	T13531	nummod	1986,Celeste
R8979	T13535	T13531	punct	),Celeste
R8980	T13536	T13529	punct	", ",Osteocalcin
R8981	T13537	T13529	cc	and,Osteocalcin
R8982	T13538	T13529	conj	Sox5,Osteocalcin
R8983	T13539	T13538	cc	and,Sox5
R8984	T13540	T13538	conj	Sox6,Sox5
R8985	T13541	T13542	punct	(,Lefebvre
R8986	T13542	T13540	meta	Lefebvre,Sox6
R8987	T13543	T13542	nmod	et,Lefebvre
R8988	T13544	T13542	nmod	al.,Lefebvre
R8989	T13545	T13542	nummod	1998,Lefebvre
R8990	T13546	T13542	punct	),Lefebvre
R8991	T13547	T13488	punct	.,published
R8992	T13549	T13550	det	The,templates
R8993	T13550	T13553	nsubj	templates,were
R8994	T13551	T13550	amod	following,templates
R8995	T13552	T13550	compound	probe,templates
R8996	T13553	T13554	ccomp	were,made
R8997	T13555	T13553	attr	gifts,were
R8998	T13556	T13553	punct	: ,were
R8999	T13557	T13553	dobj	Agg,were
R9000	T13558	T13557	punct	", ",Agg
R9001	T13559	T13560	compound	Dr.,Rosen
R9002	T13560	T13557	npadvmod	Rosen,Agg
R9003	T13561	T13560	compound	Vicki,Rosen
R9004	T13562	T13557	punct	", ",Agg
R9005	T13563	T13564	compound	Genetics,Institute
R9006	T13564	T13557	npadvmod	Institute,Agg
R9007	T13565	T13557	punct	;,Agg
R9008	T13566	T13557	appos	Bmp2,Agg
R9009	T13567	T13566	cc	and,Bmp2
R9010	T13568	T13566	conj	Bmp4,Bmp2
R9011	T13569	T13566	punct	", ",Bmp2
R9012	T13570	T13571	compound	Arend,Sidow
R9013	T13571	T13566	npadvmod	Sidow,Bmp2
R9014	T13572	T13566	punct	", ",Bmp2
R9015	T13573	T13574	compound	Stanford,University
R9016	T13574	T13566	npadvmod	University,Bmp2
R9017	T13575	T13557	punct	;,Agg
R9018	T13576	T13557	appos	Col1a1,Agg
R9019	T13577	T13576	punct	", ",Col1a1
R9020	T13578	T13579	compound	Bjorn,Olsen
R9021	T13579	T13576	npadvmod	Olsen,Col1a1
R9022	T13580	T13576	punct	", ",Col1a1
R9023	T13581	T13582	compound	Harvard,School
R9024	T13582	T13576	npadvmod	School,Col1a1
R9025	T13583	T13582	compound	Medical,School
R9026	T13584	T13554	punct	;,made
R9027	T13585	T13586	nmod	Bmpr1b,probes
R9028	T13586	T13554	nsubjpass	probes,made
R9029	T13587	T13585	punct	", ",Bmpr1b
R9030	T13588	T13585	conj	Col3a1,Bmpr1b
R9031	T13589	T13588	punct	", ",Col3a1
R9032	T13590	T13588	cc	and,Col3a1
R9033	T13591	T13588	conj	Mat4,Col3a1
R9034	T13592	T13554	auxpass	were,made
R9035	T13593	T13554	prep	from,made
R9036	T13594	T13593	pobj	ESTs,from
R9037	T13595	T13594	prep	with,ESTs
R9038	T13596	T13597	compound	IMAGE,numbers
R9039	T13597	T13595	pobj	numbers,with
R9040	T13598	T13597	compound	clone,numbers
R9041	T13599	T13597	appos	5056341,numbers
R9042	T13600	T13599	punct	", ",5056341
R9043	T13601	T13599	conj	478480,5056341
R9044	T13602	T13601	punct	", ",478480
R9045	T13603	T13601	cc	and,478480
R9046	T13604	T13601	conj	406027,478480
R9047	T13605	T13554	punct	", ",made
R9048	T13606	T13554	advmod	respectively,made
R9049	T13607	T13608	punct	(,Invitrogen
R9050	T13608	T13554	parataxis	Invitrogen,made
R9051	T13609	T13608	punct	", ",Invitrogen
R9052	T13610	T13608	npadvmod	Carlsbad,Invitrogen
R9053	T13611	T13608	punct	", ",Invitrogen
R9054	T13612	T13608	npadvmod	California,Invitrogen
R9055	T13613	T13608	punct	", ",Invitrogen
R9056	T13614	T13615	compound	United,States
R9057	T13615	T13608	npadvmod	States,Invitrogen
R9058	T13616	T13608	punct	),Invitrogen
R9059	T13617	T13554	punct	.,made
R9060	T13619	T13620	nsubjpass	Sections,fixed
R9061	T13621	T13619	prep	for,Sections
R9062	T13622	T13621	pobj	immunohistochemistry,for
R9063	T13623	T13620	auxpass	were,fixed
R9064	T13624	T13620	prep	in,fixed
R9065	T13625	T13626	nummod	4,%
R9066	T13626	T13627	compound	%,PFA
R9067	T13627	T13624	pobj	PFA,in
R9068	T13628	T13620	punct	", ",fixed
R9069	T13629	T13630	advmod	then,digested
R9070	T13630	T13620	dep	digested,fixed
R9071	T13631	T13630	prep	with,digested
R9072	T13632	T13633	quantmod	942,"2,000"
R9073	T13633	T13635	nummod	"2,000",U
R9074	T13634	T13633	punct	–,"2,000"
R9075	T13635	T13636	nmod	U,hyaluronindase
R9076	T13636	T13631	pobj	hyaluronindase,with
R9077	T13637	T13638	punct	/,ml
R9078	T13638	T13635	prep	ml,U
R9079	T13639	T13640	nmod	type,S
R9080	T13640	T13636	nmod	S,hyaluronindase
R9081	T13641	T13640	nummod	IV,S
R9082	T13642	T13640	punct	-,S
R9083	T13643	T13636	amod	bovine,hyaluronindase
R9084	T13644	T13645	punct	(,Sigma
R9085	T13645	T13636	parataxis	Sigma,hyaluronindase
R9086	T13646	T13645	punct	", ",Sigma
R9087	T13647	T13648	compound	St.,Louis
R9088	T13648	T13645	npadvmod	Louis,Sigma
R9089	T13649	T13645	punct	", ",Sigma
R9090	T13650	T13645	npadvmod	Missouri,Sigma
R9091	T13651	T13645	punct	", ",Sigma
R9092	T13652	T13653	compound	United,States
R9093	T13653	T13645	npadvmod	States,Sigma
R9094	T13654	T13645	punct	),Sigma
R9095	T13655	T13630	prep	in,digested
R9096	T13656	T13655	pobj	PBS,in
R9097	T13657	T13656	punct	(,PBS
R9098	T13658	T13656	npadvmod	pH,PBS
R9099	T13659	T13658	nummod	5,pH
R9100	T13660	T13656	punct	),PBS
R9101	T13661	T13630	prep	at,digested
R9102	T13662	T13663	nummod	37,°C
R9103	T13663	T13661	pobj	°C,at
R9104	T13664	T13630	prep	for,digested
R9105	T13665	T13666	nummod	30,min
R9106	T13666	T13664	pobj	min,for
R9107	T13667	T13666	prep	to,min
R9108	T13668	T13669	nummod	2,h
R9109	T13669	T13667	pobj	h,to
R9110	T13670	T13666	prep	depending,min
R9111	T13671	T13670	prep	on,depending
R9112	T13672	T13673	det	the,stage
R9113	T13673	T13671	pobj	stage,on
R9114	T13674	T13620	punct	.,fixed
R9115	T13676	T13677	nsubjpass	Slides,washed
R9116	T13678	T13677	auxpass	were,washed
R9117	T13679	T13677	advmod	then,washed
R9118	T13680	T13677	prep	in,washed
R9119	T13681	T13680	pobj	PBS,in
R9120	T13682	T13677	punct	", ",washed
R9121	T13683	T13677	conj	treated,washed
R9122	T13684	T13683	prep	with,treated
R9123	T13685	T13686	nummod	0.3,%
R9124	T13686	T13687	compound	%,peroxide
R9125	T13687	T13684	pobj	peroxide,with
R9126	T13688	T13687	compound	hydrogen,peroxide
R9127	T13689	T13683	prep	in,treated
R9128	T13690	T13691	nummod	100,%
R9129	T13691	T13692	compound	%,methanol
R9130	T13692	T13689	pobj	methanol,in
R9131	T13693	T13683	prep	for,treated
R9132	T13694	T13695	nummod	30,min
R9133	T13695	T13693	pobj	min,for
R9134	T13696	T13683	punct	", ",treated
R9135	T13697	T13683	conj	washed,treated
R9136	T13698	T13697	punct	", ",washed
R9137	T13699	T13697	conj	blocked,washed
R9138	T13700	T13699	prep	with,blocked
R9139	T13701	T13700	pobj	PBS,with
R9140	T13702	T13701	punct	+,PBS
R9141	T13703	T13704	nummod	0.05,%
R9142	T13704	T13705	compound	%,Tween20
R9143	T13705	T13701	appos	Tween20,PBS
R9144	T13706	T13701	punct	+,PBS
R9145	T13707	T13708	nummod	5,%
R9146	T13708	T13709	nmod	%,serum
R9147	T13709	T13701	appos	serum,PBS
R9148	T13710	T13709	nmod	goat,serum
R9149	T13711	T13710	cc	or,goat
R9150	T13712	T13713	amod	fetal,bovine
R9151	T13713	T13710	conj	bovine,goat
R9152	T13714	T13699	punct	", ",blocked
R9153	T13715	T13699	conj	washed,blocked
R9154	T13716	T13715	advmod	again,washed
R9155	T13717	T13715	punct	", ",washed
R9156	T13718	T13715	cc	and,washed
R9157	T13719	T13715	conj	incubated,washed
R9158	T13720	T13719	prep	with,incubated
R9159	T13721	T13722	amod	primary,antibodies
R9160	T13722	T13720	pobj	antibodies,with
R9161	T13723	T13719	prep	in,incubated
R9162	T13724	T13723	pobj	PBS,in
R9163	T13725	T13724	punct	+,PBS
R9164	T13726	T13727	nummod	0.05,%
R9165	T13727	T13728	compound	%,Tween
R9166	T13728	T13724	appos	Tween,PBS
R9167	T13729	T13728	nummod	20,Tween
R9168	T13730	T13724	punct	+,PBS
R9169	T13731	T13732	nummod	1,%
R9170	T13732	T13733	nmod	%,serum
R9171	T13733	T13724	appos	serum,PBS
R9172	T13734	T13733	nmod	goat,serum
R9173	T13735	T13734	cc	or,goat
R9174	T13736	T13737	amod	fetal,bovine
R9175	T13737	T13734	conj	bovine,goat
R9176	T13738	T13719	advmod	overnight,incubated
R9177	T13739	T13719	prep	at,incubated
R9178	T13740	T13741	nummod	4,°C
R9179	T13741	T13739	pobj	°C,at
R9180	T13742	T13677	punct	.,washed
R9181	T13744	T13745	npadvmod	Biotin,labeled
R9182	T13745	T13747	amod	labeled,antibodies
R9183	T13746	T13745	punct	-,labeled
R9184	T13747	T13749	nsubjpass	antibodies,tagged
R9185	T13748	T13747	amod	secondary,antibodies
R9186	T13750	T13751	punct	(,Labs
R9187	T13751	T13747	parataxis	Labs,antibodies
R9188	T13752	T13751	compound	Vector,Labs
R9189	T13753	T13751	punct	),Labs
R9190	T13754	T13749	auxpass	were,tagged
R9191	T13755	T13749	prep	with,tagged
R9192	T13756	T13755	pobj	HRP,with
R9193	T13757	T13749	advcl	using,tagged
R9194	T13758	T13759	det	the,kit
R9195	T13759	T13757	dobj	kit,using
R9196	T13760	T13761	compound	Vectastain,Elite
R9197	T13761	T13759	compound	Elite,kit
R9198	T13762	T13759	compound	ABC,kit
R9199	T13763	T13764	punct	(,Labs
R9200	T13764	T13759	parataxis	Labs,kit
R9201	T13765	T13764	compound	Vector,Labs
R9202	T13766	T13764	punct	),Labs
R9203	T13767	T13749	advcl	followed,tagged
R9204	T13768	T13767	agent	by,followed
R9205	T13769	T13768	pobj	detection,by
R9206	T13770	T13769	prep	with,detection
R9207	T13771	T13770	pobj	DAB,with
R9208	T13772	T13773	punct	(,Labs
R9209	T13773	T13771	parataxis	Labs,DAB
R9210	T13774	T13773	compound	Vector,Labs
R9211	T13775	T13773	punct	),Labs
R9212	T13776	T13749	punct	.,tagged
R9213	T13778	T13779	amod	Primary,antibodies
R9214	T13779	T13780	nsubj	antibodies,were
R9215	T13781	T13779	cc	and,antibodies
R9216	T13782	T13779	conj	dilutions,antibodies
R9217	T13783	T13779	acl	used,antibodies
R9218	T13784	T13780	punct	: ,were
R9219	T13785	T13786	nmod	goat,MMP13
R9220	T13786	T13780	attr	MMP13,were
R9221	T13787	T13785	amod	anti-mouse,goat
R9222	T13788	T13786	punct	", ",MMP13
R9223	T13789	T13786	npadvmod	1,MMP13
R9224	T13790	T13791	punct	:,100
R9225	T13791	T13789	prep	100,1
R9226	T13792	T13793	punct	(,International
R9227	T13793	T13789	parataxis	International,1
R9228	T13794	T13793	compound	Chemicon,International
R9229	T13795	T13793	punct	", ",International
R9230	T13796	T13793	npadvmod	Temecula,International
R9231	T13797	T13793	punct	", ",International
R9232	T13798	T13793	npadvmod	California,International
R9233	T13799	T13793	punct	", ",International
R9234	T13800	T13801	compound	United,States
R9235	T13801	T13793	npadvmod	States,International
R9236	T13802	T13793	punct	),International
R9237	T13803	T13786	punct	;,MMP13
R9238	T13804	T13805	nmod	rabbit,SOX9
R9239	T13805	T13786	appos	SOX9,MMP13
R9240	T13806	T13804	amod	anti-human,rabbit
R9241	T13807	T13805	punct	", ",SOX9
R9242	T13808	T13805	npadvmod	1,SOX9
R9243	T13809	T13810	punct	:,500
R9244	T13810	T13808	prep	500,1
R9245	T13811	T13812	punct	(,Morais
R9246	T13812	T13808	meta	Morais,1
R9247	T13813	T13812	nmod	da,Morais
R9248	T13814	T13812	nmod	Silva,Morais
R9249	T13815	T13812	nmod	et,Morais
R9250	T13816	T13812	nmod	al.,Morais
R9251	T13817	T13812	nummod	1996,Morais
R9252	T13818	T13812	punct	),Morais
R9253	T13819	T13786	punct	;,MMP13
R9254	T13820	T13821	nmod	rabbit,SOX9
R9255	T13821	T13786	appos	SOX9,MMP13
R9256	T13822	T13821	amod	anti-phosphorylated,SOX9
R9257	T13823	T13821	punct	-,SOX9
R9258	T13824	T13821	punct	(,SOX9
R9259	T13825	T13826	nmod	SOX9,P
R9260	T13826	T13821	appos	P,SOX9
R9261	T13827	T13826	punct	.,P
R9262	T13828	T13821	punct	),SOX9
R9263	T13829	T13821	punct	", ",SOX9
R9264	T13830	T13821	npadvmod	1,SOX9
R9265	T13831	T13832	punct	:,10
R9266	T13832	T13830	prep	10,1
R9267	T13833	T13834	punct	–,1
R9268	T13834	T13830	prep	1,1
R9269	T13835	T13836	punct	:,250
R9270	T13836	T13834	prep	250,1
R9271	T13837	T13838	punct	(,Huang
R9272	T13838	T13780	meta	Huang,were
R9273	T13839	T13838	nmod	et,Huang
R9274	T13840	T13838	nmod	al.,Huang
R9275	T13841	T13838	nummod	2000,Huang
R9276	T13842	T13838	punct	),Huang
R9277	T13843	T13780	punct	.,were
R94	T331	T327	parataxis	member,gene
R2308	T3651	T3648	prep	at,expression
R2309	T3652	T3653	det	some,time
R2310	T3653	T3651	pobj	time,at
R1080	T1864	T1840	meta	Storm,produce
R1081	T1865	T1864	cc	and,Storm
R1082	T1866	T1864	conj	Kingsley,Storm
R7249	T11038	T11039	aux	may,bring
R7250	T11039	T11017	conj	bring,enhance
R7251	T11040	T11039	dobj	us,bring
R7252	T11041	T11039	advcl	closer,bring
R7253	T11042	T11041	prep	to,closer
R7254	T11043	T11044	amod	better,prevention
R7255	T11044	T11042	pobj	prevention,to
R7256	T11045	T11044	cc	and,prevention
R7257	T11046	T11044	conj	treatment,prevention
R7258	T11047	T11044	prep	of,prevention
R7259	T11048	T11049	compound	joint,diseases
R7260	T11049	T11047	pobj	diseases,of
R7261	T11050	T11017	punct	.,enhance

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T141	823-833	GO_SO_EXT:chromosome	denotes	chromosome
T142	0-3	PR_EXT:000000034	denotes	BMP
T143	0-12	GO_EXT:0098821	denotes	BMP Receptor
T144	0-22	GO:0030509	denotes	BMP Receptor Signaling
T145	43-48	GO:0007567	denotes	natal
T146	64-83	UBERON:0010996	denotes	Articular Cartilage
T147	128-147	UBERON:0010996	denotes	Articular cartilage
T148	245-251	NCBITaxon:9606	denotes	people
T149	280-289	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T150	345-354	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T151	382-387	UBERON:0001474	denotes	bones
T152	391-396	UBERON:0004905	denotes	joint
T153	464-468	SO_EXT:0000704	denotes	gene
T154	464-479	GO:0010467	denotes	gene expression
T155	501-507	UBERON:0000479	denotes	tissue
T156	545-555	GO:0065007	denotes	regulatory
T157	577-582	NCBITaxon:10088	denotes	mouse
T158	583-587	PR_EXT:000000281	denotes	Gdf5
T159	588-592	SO_EXT:0000704	denotes	gene
T160	596-600	UBERON_EXT:bone_element_or_tissue	denotes	bone
T161	596-614	GO:0060349	denotes	bone morphogenetic
T162	596-622	PR_EXT:000000034	denotes	bone morphogenetic protein
T163	615-622	CHEBI_PR_EXT:protein	denotes	protein
T164	624-627	PR_EXT:000000034	denotes	BMP
T165	659-664	NCBITaxon:10088	denotes	mouse
T166	721-726	SO_EXT:0000704	denotes	genes
T167	754-760	UBERON:0004905	denotes	joints
T168	762-772	GO:0010467	denotes	Expression
T169	780-791	GO_EXT:recombinase	denotes	recombinase
T170	797-801	PR_EXT:000000281	denotes	Gdf5
T171	802-811	NCBITaxon:2	denotes	bacterial
T172	802-833	SO_EXT:0000153	denotes	bacterial artificial chromosome
T173	834-840	SO_EXT:sequence_cloned_entity	denotes	clones
T174	889-895	_FRAGMENT	denotes	floxed
T175	903-908	SO_EXT:0000363	denotes	genes
T176	923-929	UBERON:0004905	denotes	joints
T177	947-952	UBERON:0004905	denotes	joint
T178	965-970	UBERON:0007023	denotes	adult
T179	971-990	UBERON:0010996	denotes	articular cartilage
T180	1000-1013	UBERON:0001484	denotes	joint capsule
T181	1060-1063	PR_EXT:000000034	denotes	BMP
T182	1060-1072	GO_EXT:0098821	denotes	BMP receptor
T183	1060-1082	GO:0030509	denotes	BMP receptor signaling
T184	1086-1091	UBERON:0004905	denotes	joint
T185	1105-1109	NCBITaxon:10088	denotes	Mice
T186	1115-1119	SO_EXT:sequence_nullness	denotes	null
T187	1120-1129	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T188	1133-1139	PR_EXT:000000035	denotes	Bmpr1a
T189	1153-1156	GO:0016265	denotes	die
T190	1166-1179	GO:0009790	denotes	embryogenesis
T191	1224-1230	SO:0000359	denotes	floxed
T192	1231-1237	PR_EXT:000000035	denotes	Bmpr1a
T193	1238-1244	SO_EXT:0001023	denotes	allele
T194	1254-1258	PR_EXT:000000281	denotes	Gdf5
T195	1284-1293	UBERON:0000922	denotes	embryonic
T196	1294-1303	GO_EXT:fatality_or_lethality	denotes	lethality
T197	1318-1323	GO:0007567	denotes	birth
T198	1332-1337	GO:0007567	denotes	natal
T199	1353-1357	NCBITaxon:10088	denotes	mice
T200	1370-1376	PR_EXT:000000035	denotes	Bmpr1a
T201	1377-1381	SO_EXT:0000704	denotes	gene
T202	1385-1394	UBERON:0004905	denotes	articular
T203	1409-1415	UBERON:0004905	denotes	joints
T204	1423-1427	UBERON_EXT:body	denotes	body
T205	1460-1466	PR_EXT:000000035	denotes	Bmpr1a
T206	1467-1475	GO_EXT:0004872	denotes	receptor
T207	1495-1514	UBERON:0010996	denotes	articular cartilage
T208	1526-1532	UBERON:0004905	denotes	joints
T209	1557-1565	GO_EXT:0004872	denotes	receptor
T210	1576-1580	NCBITaxon:10088	denotes	mice
T211	1587-1592	GO:0007567	denotes	birth
T212	1617-1622	NCBITaxon:9606	denotes	human
T213	1639-1643	PR_EXT:000000281	denotes	Gdf5
T214	1648-1652	NCBITaxon:10088	denotes	mice
T215	1715-1720	SO_EXT:0000704	denotes	genes
T216	1724-1733	UBERON:0004905	denotes	articular
T217	1743-1746	PR_EXT:000000034	denotes	BMP
T218	1743-1755	GO_EXT:0098821	denotes	BMP receptor
T219	1743-1765	GO:0030509	denotes	BMP receptor signaling
T220	1797-1808	_FRAGMENT	denotes	development
T221	1822-1824	_FRAGMENT	denotes	of
T222	1834-1841	GO:0009888	denotes	tissues
T223	1813-1824	_FRAGMENT	denotes	creation of
T224	1834-1841	UBERON:0000479	denotes	tissues
T225	1879-1898	UBERON:0010996	denotes	articular cartilage
T226	1905-1910	GO:0007567	denotes	birth
T227	1912-1919	SO_EXT:0000704	denotes	Genetic
T228	1920-1929	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T229	1949-1952	PR_EXT:000000034	denotes	BMP
T230	1949-1961	GO_EXT:0098821	denotes	BMP receptor
T231	1949-1971	GO:0030509	denotes	BMP receptor signaling
T232	2007-2012	NCBITaxon:9606	denotes	human
T233	2066-2069	PR_EXT:000000034	denotes	BMP
T234	2066-2078	GO_EXT:0098821	denotes	BMP receptor
T235	2066-2088	GO:0030509	denotes	BMP receptor signaling
T236	2177-2182	UBERON:0004905	denotes	joint
T872	2393-2412	UBERON:0010996	denotes	articular cartilage
T873	2422-2427	UBERON:0001474	denotes	bones
T874	2431-2446	UBERON:0002217	denotes	synovial joints
T875	2582-2601	UBERON:0010996	denotes	articular cartilage
T876	2700-2706	UBERON:0007023	denotes	adults
T877	2738-2744	NCBITaxon:9606	denotes	people
T878	2819-2825	NCBITaxon:9606	denotes	people
T879	2915-2924	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T880	2961-2980	UBERON:0010996	denotes	articular cartilage
T881	3022-3027	UBERON:0004905	denotes	joint
T882	3079-3084	UBERON:0004905	denotes	Joint
T883	3109-3122	GO:0009790	denotes	embryogenesis
T884	3145-3149	CL_GO_EXT:cell	denotes	cell
T885	3199-3207	UBERON:0004288	denotes	skeletal
T886	3234-3255	GO:0012501	denotes	Programmed cell death
T887	3245-3249	CL_GO_EXT:cell	denotes	cell
T888	3351-3355	CL_GO_EXT:cell	denotes	cell
T889	3391-3395	CL_GO_EXT:cell	denotes	cell
T890	3409-3414	UBERON:0004905	denotes	joint
T891	3433-3441	UBERON:0004288	denotes	skeleton
T892	3465-3474	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T893	3515-3519	UBERON_EXT:bone_element_or_tissue	denotes	bone
T894	3530-3535	CL_GO_EXT:cell	denotes	cells
T895	3656-3675	UBERON:0010996	denotes	articular cartilage
T896	3696-3701	UBERON:0004905	denotes	joint
T897	3782-3800	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling pathways
T898	3840-3845	UBERON:0004905	denotes	joint
T899	3857-3862	PR_EXT:000017452	denotes	Wnt14
T900	3866-3875	GO:0010467	denotes	expressed
T901	3906-3912	UBERON:0004905	denotes	joints
T902	3954-3964	GO:0010467	denotes	expression
T903	3974-3979	UBERON:0004905	denotes	joint
T904	3980-3987	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T905	3996-4005	GO:0010467	denotes	expressed
T906	4030-4034	UBERON:0002101	denotes	limb
T907	4085-4089	UBERON_EXT:bone_element_or_tissue	denotes	bone
T908	4085-4103	GO:0060349	denotes	bone morphogenetic
T909	4085-4111	PR_EXT:000000034	denotes	bone morphogenetic protein
T910	4104-4111	CHEBI_PR_EXT:protein	denotes	protein
T911	4113-4116	PR_EXT:000000034	denotes	BMP
T912	4128-4136	GO:0046903	denotes	secreted
T913	4137-4146	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling
T914	4137-4156	CHEBI_EXT:62488	denotes	signaling molecules
T915	4166-4175	GO:0010467	denotes	expressed
T916	4202-4208	UBERON:0004905	denotes	joints
T917	4236-4243	SO_EXT:sequence_coding_function	denotes	encoded
T918	4251-4256	SO_EXT:0000704	denotes	genes
T919	4257-4261	PR_EXT:000000281	denotes	Gdf5
T920	4263-4267	PR_EXT:000007924	denotes	Gdf6
T921	4269-4273	PR_EXT:000000282	denotes	Gdf7
T922	4275-4279	PR_EXT:000000164	denotes	Bmp2
T923	4285-4289	PR_EXT:000000165	denotes	Bmp4
T924	4394-4398	PR_EXT:000000281	denotes	Gdf5
T925	4399-4409	GO:0010467	denotes	expression
T926	4454-4460	UBERON:0004905	denotes	joints
T927	4507-4514	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T928	4518-4523	UBERON:0004905	denotes	joint
T929	4535-4544	SO_EXT:sequence_alteration_entity_or_process	denotes	Mutations
T930	4555-4559	PR_EXT:000000281	denotes	Gdf5
T931	4583-4587	PR_EXT:000007924	denotes	Gdf6
T932	4588-4592	SO_EXT:0000704	denotes	gene
T933	4617-4623	UBERON:0004905	denotes	joints
T934	4684-4693	CHEBI:36357	denotes	molecules
T935	4716-4721	UBERON:0004905	denotes	joint
T936	4790-4799	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T937	4803-4807	PR_EXT:000000164	denotes	Bmp2
T938	4811-4815	PR_EXT:000000165	denotes	Bmp4
T939	4822-4837	UBERON:0019248	denotes	early embryonic
T940	4838-4847	GO_EXT:fatality_or_lethality	denotes	lethality
T941	4891-4896	UBERON:0004905	denotes	joint
T942	4983-5001	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling pathways
T943	5033-5043	GO_PATO_EXT:biological_maturation	denotes	maturation
T944	5063-5068	UBERON:0007023	denotes	adult
T945	5069-5074	UBERON:0004905	denotes	joint
T946	5100-5103	PR_EXT:000000034	denotes	BMP
T947	5100-5113	GO:0030509	denotes	BMP signaling
T948	5140-5145	UBERON:0007023	denotes	adult
T949	5146-5165	UBERON:0010996	denotes	articular cartilage
T950	5380-5384	PR_EXT:000000034	denotes	BMPs
T951	5385-5389	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T952	5390-5410	GO_EXT:tetrameric_macromolecular_complex	denotes	tetrameric complexes
T953	5401-5413	GO:0043235	denotes	complexes of
T954	5441-5488	GO_EXT:0004675	denotes	transmembrane serine-threonine kinase receptors
T955	5446-5454	GO:0016020	denotes	membrane
T956	5455-5461	CHEBI_SO_EXT:serine	denotes	serine
T957	5462-5471	CHEBI_SO_EXT:threonine	denotes	threonine
T958	5479-5488	GO:0043235	denotes	receptors
T959	5495-5498	PR_EXT:000000034	denotes	BMP
T960	5499-5506	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T961	5514-5523	GO:0032991	denotes	complexes
T962	5546-5561	GO_PATO_EXT:phosphorylation_process	denotes	phosphorylating
T963	5577-5581	GO_PR_EXT:SMAD	denotes	Smad
T964	5592-5605	GO_EXT:transcription	denotes	transcription
T965	5592-5613	GO_EXT:transcription_factor	denotes	transcription factors
T966	5680-5700	PR_EXT:BMP_type_1_receptor	denotes	BMP type I receptors
T967	5691-5700	GO_EXT:0004872	denotes	receptors
T968	5704-5712	UBERON:0004288	denotes	skeletal
T969	5713-5723	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T970	5725-5731	PR_EXT:000000035	denotes	BMPR1A
T971	5736-5742	PR_EXT:000000036	denotes	BMPR1B
T972	5749-5758	GO_EXT:0004872	denotes	receptors
T973	5763-5767	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	bind
T974	5768-5772	PR_EXT:000000164	denotes	BMP2
T975	5774-5778	PR_EXT:000000165	denotes	BMP4
T976	5784-5788	PR_EXT:000000281	denotes	GDF5
T977	5799-5803	PR_EXT:000000281	denotes	GDF5
T978	5830-5836	PR_EXT:000000036	denotes	BMPR1B
T979	5950-5959	GO_EXT:0004872	denotes	receptors
T980	5969-5978	GO:0010467	denotes	expressed
T981	6029-6034	UBERON:0002101	denotes	limbs
T982	6036-6042	PR_EXT:000000035	denotes	Bmpr1a
T983	6043-6053	GO:0010467	denotes	expression
T984	6076-6081	UBERON:0004905	denotes	joint
T985	6094-6107	UBERON:0002222	denotes	perichondrium
T986	6113-6122	UBERON:0004905	denotes	articular
T987	6123-6132	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T988	6134-6159	CL:0000743	denotes	hypertrophic chondrocytes
T989	6165-6193	UBERON:0009585	denotes	interdigital limb mesenchyme
T990	6210-6216	PR_EXT:000000036	denotes	Bmpr1b
T991	6217-6227	GO:0010467	denotes	expression
T992	6249-6259	_FRAGMENT	denotes	condensing
T993	6277-6294	CL:0000335	denotes	mesenchymal cells
T994	6263-6276	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilaginous
T995	6277-6288	UBERON:0003104	denotes	mesenchymal
T996	6289-6294	CL_GO_EXT:cell	denotes	cells
T997	6313-6318	UBERON:0004905	denotes	joint
T998	6331-6344	UBERON:0002222	denotes	perichondrium
T999	6354-6363	UBERON:0004905	denotes	articular
T1000	6364-6373	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T1001	6452-6456	SO_EXT:sequence_nullness	denotes	Null
T1002	6457-6466	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T1003	6474-6480	PR_EXT:000000036	denotes	Bmpr1b
T1004	6481-6485	SO_EXT:0000704	denotes	gene
T1005	6501-6505	NCBITaxon:10088	denotes	mice
T1006	6522-6526	UBERON_EXT:bone_element_or_tissue	denotes	bone
T1007	6522-6526	_FRAGMENT	denotes	bone
T1008	6537-6546	GO_EXT:bone_development_or_ossification	denotes	formation
T1009	6531-6536	UBERON:0004905	denotes	joint
T1010	6583-6587	NCBITaxon:10088	denotes	mice
T1011	6596-6600	PR_EXT:000000281	denotes	Gdf5
T1012	6662-6666	SO_EXT:sequence_nullness	denotes	Null
T1013	6667-6676	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T1014	6680-6686	PR_EXT:000000035	denotes	Bmpr1a
T1015	6699-6708	UBERON:0000922	denotes	embryonic
T1016	6709-6718	GO_EXT:fatality_or_lethality	denotes	lethality
T1017	6736-6748	GO:0007369	denotes	gastrulation
T1018	6774-6778	NCBITaxon:10088	denotes	mice
T1019	6784-6793	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T1020	6797-6801	PR_EXT:000000165	denotes	Bmp4
T1021	6866-6872	SO:0000359	denotes	floxed
T1022	6873-6880	SO_EXT:0001023	denotes	alleles
T1023	6894-6900	PR_EXT:000000035	denotes	Bmpr1a
T1024	6972-6976	UBERON_EXT:bone_element_or_tissue	denotes	bone
T1025	6972-6976	_FRAGMENT	denotes	bone
T1026	6987-6996	GO_EXT:bone_development_or_ossification	denotes	formation
T1027	6981-6986	UBERON:0004905	denotes	joint
T1028	7040-7047	SO_EXT:0000704	denotes	genetic
T1029	7086-7091	SO_EXT:0000704	denotes	genes
T1030	7108-7113	UBERON:0004905	denotes	joint
T1031	7114-7121	UBERON:0000479	denotes	tissues
T1032	7174-7179	UBERON:0004905	denotes	joint
T1033	7237-7243	UBERON:0000479	denotes	tissue
T1034	7253-7263	GO:0010467	denotes	expression
T1035	7279-7283	PR_EXT:000000281	denotes	Gdf5
T1036	7284-7288	SO_EXT:0000704	denotes	gene
T1037	7307-7311	SO_EXT:0000346	denotes	loxP
T1038	7332-7336	PR_EXT:000000281	denotes	Gdf5
T1039	7384-7391	GO:0010467	denotes	express
T1040	7392-7397	SO_EXT:0000704	denotes	genes
T1041	7401-7407	UBERON:0004905	denotes	joints
T1042	7429-7433	NCBITaxon:10088	denotes	mice
T1043	7470-7479	SO_EXT:sequence_alteration_process	denotes	modifying
T1044	7480-7485	SO_EXT:0000704	denotes	genes
T1045	7525-7539	UBERON:0002217	denotes	synovial joint
T1046	7555-7564	UBERON:0000211	denotes	ligaments
T1047	7572-7585	UBERON:0001484	denotes	joint capsule
T1048	7591-7608	UBERON_EXT:synovial_membrane	denotes	synovial membrane
T1049	7618-7637	UBERON:0010996	denotes	articular cartilage
T1050	7639-7643	PR_EXT:000000281	denotes	Gdf5
T1051	7648-7661	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T1052	7675-7690	UBERON:0019248	denotes	early embryonic
T1053	7691-7700	GO_EXT:fatality_or_lethality	denotes	lethality
T1054	7704-7708	SO_EXT:sequence_nullness	denotes	null
T1055	7709-7718	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T1056	7722-7728	PR_EXT:000000035	denotes	Bmpr1a
T1057	7750-7758	GO_EXT:0004872	denotes	receptor
T1058	7781-7786	UBERON:0004905	denotes	joint
T1059	7837-7858	GO:0012501	denotes	programmed cell death
T1060	7848-7852	CL_GO_EXT:cell	denotes	cell
T1061	7862-7884	UBERON:0006015	denotes	webbing between digits
T1062	7901-7907	PR_EXT:000000035	denotes	Bmpr1a
T1063	7933-7938	GO:0007567	denotes	natal
T1064	7954-7973	UBERON:0010996	denotes	articular cartilage
T1065	7997-8005	UBERON:0004288	denotes	skeleton
T1066	8010-8014	PR_EXT:000000281	denotes	Gdf5
T1067	8019-8025	PR_EXT:000000035	denotes	Bmpr1a
T1068	8025-8030	SO:0000359	denotes	floxP
T1069	8031-8035	NCBITaxon:10088	denotes	mice
T1070	8037-8056	UBERON:0010996	denotes	articular cartilage
T1071	8106-8116	GO:0010467	denotes	expression
T1072	8132-8141	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T1073	8142-8149	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T1074	8156-8161	GO:0007567	denotes	birth
T1075	8294-8297	PR_EXT:000000034	denotes	BMP
T1076	8294-8307	GO:0030509	denotes	BMP signaling
T1077	8350-8355	GO:0007567	denotes	natal
T1078	8356-8375	UBERON:0010996	denotes	articular cartilage
T1079	8386-8399	_FRAGMENT	denotes	modulation of
T1080	8404-8425	GO:0030510	denotes	BMP signaling pathway
T1081	8404-8407	PR_EXT:000000034	denotes	BMP
T1082	8456-8461	UBERON:0004905	denotes	joint
T2483	8481-8488	SO_EXT:0000704	denotes	Genetic
T2484	8524-8529	SO_EXT:0000704	denotes	Genes
T2485	8533-8538	UBERON:0004905	denotes	Joint
T2486	8612-8617	SO_EXT:0000704	denotes	genes
T2487	8635-8649	UBERON:0000982	denotes	skeletal joint
T2488	8677-8687	SO_EXT:transgenic_entity	denotes	transgenic
T2489	8688-8692	NCBITaxon:10088	denotes	mice
T2490	8696-8703	GO:0010467	denotes	express
T2491	8708-8719	GO_EXT:recombinase	denotes	recombinase
T2492	8734-8740	UBERON:0004905	denotes	joints
T2493	8753-8757	PR_EXT:000000281	denotes	Gdf5
T2494	8763-8767	SO_EXT:0000704	denotes	gene
T2495	8777-8786	GO:0010467	denotes	expressed
T2496	8816-8833	UBERON:0004765	denotes	skeletal elements
T2497	8841-8850	UBERON:0000922	denotes	embryonic
T2498	8841-8850	_FRAGMENT	denotes	embryonic
T2499	8857-8866	GO:0009790	denotes	formation
T2500	8851-8856	UBERON:0004905	denotes	joint
T2501	8870-8879	NCBITaxon:2	denotes	bacterial
T2502	8870-8901	SO_EXT:0000153	denotes	bacterial artificial chromosome
T2503	8891-8901	GO_SO_EXT:chromosome	denotes	chromosome
T2504	8903-8906	SO_EXT:0000153	denotes	BAC
T2505	8923-8927	PR_EXT:000000281	denotes	Gdf5
T2506	8938-8946	SO_EXT:sequence_alteration_process	denotes	modified
T2507	8961-8974	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2508	8978-8986	NCBITaxon:2	denotes	bacteria
T2509	8990-8996	SO_EXT:sequence_insertion_process	denotes	insert
T2510	8999-9007	SO_EXT:0005853	denotes	cassette
T2511	9008-9016	SO_EXT:sequence_coding_function	denotes	encoding
T2512	9021-9049	SO_EXT:0000243	denotes	internal ribosome entry site
T2513	9030-9038	GO:0005840	denotes	ribosome
T2514	9051-9055	SO_EXT:0000243	denotes	IRES
T2515	9057-9062	NCBITaxon:9606	denotes	human
T2516	9063-9072	UBERON:0001987	denotes	placental
T2517	9063-9093	PR_EXT:000003969	denotes	placental alkaline phosphatase
T2518	9073-9093	GO_PR_EXT:alkaline_phosphatase	denotes	alkaline phosphatase
T2519	9095-9100	PR_EXT:P05187	denotes	hPLAP
T2520	9111-9128	GO:0006413	denotes	translation start
T2521	9111-9133	SO_EXT:0000318	denotes	translation start site
T2522	9137-9141	PR_EXT:000000281	denotes	Gdf5
T2523	9160-9168	SO_EXT:sequence_alteration_process	denotes	modified
T2524	9169-9172	SO_EXT:0000153	denotes	BAC
T2525	9204-9214	SO_EXT:transgenic_entity	denotes	transgenic
T2526	9215-9219	NCBITaxon:10088	denotes	mice
T2527	9235-9239	PR_EXT:000000281	denotes	Gdf5
T2528	9244-9254	SO_EXT:transgenic_entity	denotes	transgenic
T2529	9255-9259	NCBITaxon:10088	denotes	mice
T2530	9276-9285	SO_EXT:0000902	denotes	transgene
T2531	9286-9296	GO:0010467	denotes	expression
T2532	9305-9316	GO_EXT:recombinase	denotes	recombinase
T2533	9360-9364	NCBITaxon:10088	denotes	mice
T2534	9383-9393	GO:0010467	denotes	expression
T2535	9397-9401	PR_EXT:000033987	denotes	lacZ
T2536	9432-9447	GO_EXT:transcription	denotes	transcriptional
T2537	9432-9462	SO_EXT:0000616	denotes	transcriptional stop sequences
T2538	9524-9534	GO:0010467	denotes	expression
T2539	9542-9551	SO_EXT:0000902	denotes	transgene
T2540	9564-9569	PR_EXT:P05187	denotes	HPLAP
T2541	9587-9600	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2542	9604-9607	CHEBI_SO_EXT:DNA	denotes	DNA
T2543	9620-9624	PR_EXT:000033987	denotes	LACZ
T2544	9682-9686	PR_EXT:000033987	denotes	LACZ
T2545	9687-9697	GO:0010467	denotes	expression
T2546	9711-9717	UBERON:0004905	denotes	joints
T2547	9745-9750	PR_EXT:P05187	denotes	HPLAP
T2548	9751-9761	GO:0010467	denotes	expression
T2549	9784-9789	UBERON:0004905	denotes	joint
T2550	9814-9819	PR_EXT:P05187	denotes	HPLAP
T2551	9820-9830	GO:0010467	denotes	expression
T2552	9838-9842	PR_EXT:000000281	denotes	Gdf5
T2553	9847-9857	SO_EXT:transgenic_entity	denotes	transgenic
T2554	9894-9902	GO_EXT:breeding	denotes	breeding
T2555	9935-9939	PR_EXT:000033987	denotes	LACZ
T2556	9940-9950	GO:0010467	denotes	expression
T2557	9984-9990	UBERON:0004905	denotes	joints
T2558	9998-10004	UBERON:0002544	denotes	digits
T2559	10084-10088	PR_EXT:000000281	denotes	Gdf5
T2560	10093-10102	SO_EXT:0000902	denotes	transgene
T2561	10103-10112	GO:0010467	denotes	expresses
T2562	10117-10128	GO_EXT:recombinase	denotes	recombinase
T2563	10140-10143	CHEBI_SO_EXT:DNA	denotes	DNA
T2564	10144-10157	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2565	10172-10177	UBERON:0004905	denotes	joint
T2566	11857-11861	NCBITaxon:10088	denotes	mice
T2567	11880-11884	PR_EXT:000033987	denotes	lacZ
T2568	11919-11923	NCBITaxon:10088	denotes	mice
T2569	11963-11967	PR_EXT:000033987	denotes	lacZ
T2570	11968-11981	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2571	12006-12012	UBERON:0004905	denotes	Joints
T2572	12027-12032	UBERON:0002101	denotes	limbs
T2573	12090-12104	UBERON:0016884	denotes	shoulder joint
T2574	12124-12135	UBERON:0001490	denotes	elbow joint
T2575	12178-12183	UBERON:0004905	denotes	joint
T2576	12375-12380	UBERON:0004905	denotes	joint
T2577	12400-12405	UBERON:0002101	denotes	limbs
T2578	12407-12411	PR_EXT:000033987	denotes	LACZ
T2579	12432-12441	UBERON:0000922	denotes	embryonic
T2580	12480-12486	UBERON:0004905	denotes	joints
T2581	12502-12510	UBERON:0001467	denotes	shoulder
T2582	12515-12519	UBERON:0001465	denotes	knee
T2583	12550-12554	PR_EXT:000033987	denotes	LACZ
T2584	12555-12565	GO:0010467	denotes	expression
T2585	12611-12620	_FRAGMENT	denotes	joints of
T2586	12625-12630	UBERON:0003657	denotes	limbs
T2587	12708-12718	GO:0010467	denotes	expression
T2588	12724-12730	UBERON:0000922	denotes	embryo
T2589	12734-12740	UBERON:0000922	denotes	embryo
T2590	12765-12772	UBERON:0000922	denotes	embryos
T2591	12807-12817	UBERON:0009552	denotes	fingertips
T2592	12841-12847	UBERON:0000922	denotes	embryo
T2593	12898-12904	UBERON:0000922	denotes	embryo
T2594	12953-12959	UBERON:0004905	denotes	joints
T2595	12970-12974	PR_EXT:000033987	denotes	LACZ
T2596	12994-12999	CL_GO_EXT:cell	denotes	cells
T2597	13052-13062	GO:0010467	denotes	expression
T2598	13066-13070	PR_EXT:000033987	denotes	LACZ
T2599	13089-13094	UBERON:0004905	denotes	joint
T2600	13095-13100	CL_GO_EXT:cell	denotes	cells
T2601	13176-13186	UBERON:0001485	denotes	knee joint
T2602	13213-13230	UBERON:0006658	denotes	phalangeal joints
T2603	13282-13290	UBERON:0004288	denotes	skeleton
T2604	13305-13315	GO:0010467	denotes	expression
T2605	13319-13323	PR_EXT:000033987	denotes	LACZ
T2606	13355-13361	UBERON:0004905	denotes	joints
T2607	13439-13444	GO:0007567	denotes	natal
T2608	13445-13460	UBERON:0002217	denotes	synovial joints
T2609	13475-13494	UBERON:0010996	denotes	articular cartilage
T2610	13496-13509	UBERON:0001484	denotes	joint capsule
T2611	13515-13532	UBERON_EXT:synovial_membrane	denotes	synovial membrane
T2612	13628-13638	GO:0010467	denotes	expression
T2613	13642-13646	PR_EXT:000000281	denotes	Gdf5
T2614	13675-13684	UBERON:0000922	denotes	embryonic
T2615	13675-13696	GO:0009790	denotes	embryonic development
T2616	13724-13729	UBERON:0007023	denotes	Adult
T2617	13730-13740	GO:0010467	denotes	expression
T2618	13757-13761	PR_EXT:000000281	denotes	Gdf5
T2619	13762-13766	SO_EXT:0000704	denotes	gene
T2620	13802-13806	PR_EXT:000000281	denotes	Gdf5
T2621	13807-13817	GO:0010467	denotes	expression
T2622	13850-13855	UBERON:0007023	denotes	adult
T2623	13856-13875	UBERON:0010996	denotes	articular cartilage
T2624	13887-13889	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T2625	15401-15412	UBERON:0003657	denotes	limb joints
T2626	15436-15440	PR_EXT:000033987	denotes	lacZ
T2627	15441-15451	GO:0010467	denotes	expression
T2628	15472-15476	PR_EXT:000033987	denotes	LACZ
T2629	15541-15549	UBERON:0004347	denotes	limb bud
T2630	15573-15577	PR_EXT:000033987	denotes	LACZ
T2631	15619-15629	UBERON:0001757	denotes	ear pinnae
T2632	15631-15635	UBERON:0002228	denotes	ribs
T2633	15637-15644	UBERON:0000975	denotes	sternum
T2634	15646-15653	UBERON:0000479	denotes	tissues
T2635	15661-15665	UBERON:0001456	denotes	face
T2636	15676-15686	_FRAGMENT	denotes	regions of
T2637	15691-15696	UBERON:0002616	denotes	brain
T2638	15701-15712	UBERON:0001948	denotes	spinal cord
T2639	15748-15753	GO:0007567	denotes	birth
T2640	15755-15759	PR_EXT:000033987	denotes	LACZ
T2641	15768-15777	GO:0010467	denotes	expressed
T2642	15781-15788	UBERON:0000043	denotes	tendons
T2643	15807-15823	UBERON:0001130	denotes	vertebral column
T2644	15836-15843	UBERON:0000043	denotes	tendons
T2645	15851-15856	UBERON:0004452	denotes	wrist
T2646	15861-15866	UBERON:0004454	denotes	ankle
T2647	15877-15883	UBERON:0000043	denotes	tendon
T2648	15943-15947	PR_EXT:000033987	denotes	LACZ
T2649	15956-15965	GO:0010467	denotes	expressed
T2650	15973-15987	UBERON:0002073	denotes	hair follicles
T2651	15989-16002	UBERON:0001867	denotes	ear cartilage
T2652	16009-16014	CL_GO_EXT:cell	denotes	cells
T2653	16022-16028	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2654	16022-16037	_FRAGMENT	denotes	growth plate of
T2655	16042-16052	UBERON:0002516	denotes	long bones
T2656	16058-16069	_FRAGMENT	denotes	portions of
T2657	16074-16079	UBERON:0002616	denotes	brain
T2658	16084-16095	UBERON:0001948	denotes	spinal cord
T2659	16150-16160	SO_EXT:transgenic_entity	denotes	transgenic
T2660	16161-16165	NCBITaxon:10088	denotes	mice
T2661	16216-16220	PR_EXT:000033987	denotes	LACZ
T2662	16221-16231	GO:0010467	denotes	expression
T2663	16276-16283	UBERON:0000479	denotes	tissues
T2664	16291-16297	NCBITaxon:33208	denotes	animal
T2665	16318-16328	GO:0010467	denotes	expression
T2666	16336-16345	SO_EXT:0000902	denotes	transgene
T2667	16368-16373	PR_EXT:P05187	denotes	HPLAP
T2668	16417-16423	UBERON:0004905	denotes	joints
T2669	16427-16434	NCBITaxon:33208	denotes	animals
T2670	16474-16487	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2671	16497-16501	PR_EXT:000033987	denotes	LACZ
T2672	16502-16512	GO:0010467	denotes	expression
T2673	16569-16576	NCBITaxon:33208	denotes	animals
T2674	16587-16597	GO:0010467	denotes	expression
T2675	16677-16690	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2676	16695-16699	PR_EXT:000033987	denotes	LACZ
T2677	16700-16710	GO:0010467	denotes	expression
T2678	16734-16741	NCBITaxon:33208	denotes	animals
T2679	16755-16768	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T2680	16838-16845	NCBITaxon:33208	denotes	animals
T2681	16922-16927	SO_EXT:0000704	denotes	genes
T3843	17007-17011	PR_EXT:000000281	denotes	Gdf5
T3844	17016-17022	PR_EXT:000000035	denotes	Bmpr1a
T3845	17022-17027	SO:0000359	denotes	floxP
T3846	17028-17035	NCBITaxon:33208	denotes	Animals
T3847	17047-17056	UBERON:0000113	denotes	Adulthood
T3848	17062-17065	UBERON:0001690	denotes	Ear
T3849	17080-17085	UBERON:0004905	denotes	Joint
T3850	17111-17115	PR_EXT:000000281	denotes	Gdf5
T3851	17147-17150	PR_EXT:000000034	denotes	BMP
T3852	17147-17160	GO:0030509	denotes	BMP signaling
T3853	17175-17180	UBERON:0004905	denotes	joint
T3854	17194-17198	PR_EXT:000000281	denotes	Gdf5
T3855	17203-17213	SO_EXT:transgenic_entity	denotes	transgenic
T3856	17214-17218	NCBITaxon:10088	denotes	mice
T3857	17224-17228	GO_EXT:breeding	denotes	bred
T3858	17232-17239	NCBITaxon:33208	denotes	animals
T3859	17263-17269	SO:0000359	denotes	floxed
T3860	17270-17276	SO_EXT:0001023	denotes	allele
T3861	17284-17290	PR_EXT:000000035	denotes	Bmpr1a
T3862	17365-17371	SO_EXT:0001023	denotes	allele
T3863	17429-17442	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T3864	17524-17528	SO_EXT:0000147	denotes	exon
T3865	17536-17542	PR_EXT:000000035	denotes	Bmpr1a
T3866	17543-17547	SO_EXT:0000704	denotes	gene
T3867	17552-17559	SO_EXT:sequence_deletion_process	denotes	deleted
T3868	17563-17567	NCBITaxon:10088	denotes	mice
T3869	17590-17594	PR_EXT:000000281	denotes	Gdf5
T3870	17599-17608	SO_EXT:0000902	denotes	transgene
T3871	17666-17676	GO_SO_EXT:sequence_rearrangement_process	denotes	recombined
T3872	17677-17683	PR_EXT:000000035	denotes	Bmpr1a
T3873	17683-17688	SO:0000359	denotes	floxP
T3874	17689-17695	SO_EXT:0001023	denotes	allele
T3875	17705-17709	SO_EXT:sequence_nullness	denotes	null
T3876	17710-17716	SO_EXT:0001023	denotes	allele
T3877	17724-17730	PR_EXT:000000035	denotes	Bmpr1a
T3878	17802-17806	PR_EXT:000000281	denotes	Gdf5
T3879	17811-17817	PR_EXT:000000035	denotes	Bmpr1a
T3880	17817-17822	SO:0000359	denotes	floxP
T3881	17844-17848	NCBITaxon:10088	denotes	mice
T3882	17877-17886	UBERON:0000113	denotes	adulthood
T3883	17905-17909	PR_EXT:000000281	denotes	Gdf5
T3884	17936-17951	UBERON:0019248	denotes	early embryonic
T3885	17952-17961	GO_EXT:fatality_or_lethality	denotes	lethality
T3886	17985-17992	NCBITaxon:33208	denotes	animals
T3887	18000-18004	SO_EXT:sequence_nullness	denotes	null
T3888	18005-18013	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3889	18021-18027	PR_EXT:000000035	denotes	Bmpr1a
T3890	18894-18898	PR_EXT:000000281	denotes	Gdf5
T3891	18903-18909	PR_EXT:000000035	denotes	Bmpr1a
T3892	18909-18914	SO:0000359	denotes	floxP
T3893	18915-18919	NCBITaxon:10088	denotes	mice
T3894	18979-18983	NCBITaxon:10088	denotes	mice
T3895	18996-19000	UBERON:0001690	denotes	ears
T3896	19038-19043	UBERON:0000033	denotes	heads
T3897	19096-19103	SO_EXT:sequence_altered_entity	denotes	mutants
T3898	19140-19143	PR_EXT:000000034	denotes	BMP
T3899	19140-19153	GO:0030509	denotes	BMP signaling
T3900	19182-19188	GO_EXT:biological_growth_entity_or_process	denotes	growth
T3901	19196-19208	UBERON:0001691	denotes	external ear
T3902	19212-19216	NCBITaxon:10088	denotes	mice
T3903	19284-19290	PR_EXT:000000035	denotes	Bmpr1a
T3904	19319-19322	UBERON:0001690	denotes	ear
T3905	19323-19328	CL_GO_EXT:cell	denotes	cells
T3906	19334-19341	GO:0010467	denotes	express
T3907	19346-19350	PR_EXT:000000281	denotes	Gdf5
T3908	19355-19364	SO_EXT:0000902	denotes	transgene
T3909	19371-19377	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3910	19378-19382	NCBITaxon:10088	denotes	mice
T3911	19400-19406	UBERON:0000479	denotes	tissue
T3912	19434-19449	_FRAGMENT	denotes	webbing between
T3913	19471-19480	_FRAGMENT	denotes	digits of
T3914	19487-19491	UBERON:0008439	denotes	feet
T3915	19454-19459	_FRAGMENT	denotes	first
T3916	19487-19491	UBERON:0003631	denotes	feet
T3917	19464-19480	_FRAGMENT	denotes	second digits of
T3918	19487-19491	UBERON:0003632	denotes	feet
T3919	19551-19560	UBERON:0002102	denotes	forelimbs
T3920	19585-19593	UBERON:0002398	denotes	forefeet
T3921	19621-19629	UBERON:0002387	denotes	hindfeet
T3922	19641-19647	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3923	19648-19655	NCBITaxon:33208	denotes	animals
T3924	19671-19679	UBERON:0004288	denotes	skeletal
T3925	19703-19711	UBERON:0004288	denotes	skeletal
T3926	19747-19753	UBERON:0004454	denotes	ankles
T3927	19755-19761	UBERON:0004905	denotes	joints
T3928	19808-19813	UBERON:0001474	denotes	bones
T3929	19864-19884	UBERON:0001453	denotes	second distal tarsal
T3930	19902-19921	UBERON:4200011	denotes	central tarsal bone
T3931	19952-19958	NCBITaxon:33208	denotes	animal
T3932	20070-20076	UBERON:0004905	denotes	joints
T3933	20142-20151	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T3934	20152-20158	GO:0031012	denotes	matrix
T3935	20159-20165	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T3936	20257-20266	UBERON:0004905	denotes	articular
T3937	20288-20314	UBERON:0004129	denotes	cartilaginous growth plate
T3938	20302-20308	GO_EXT:biological_growth_entity_or_process	denotes	growth
T3939	20369-20375	PR_EXT:000000035	denotes	Bmpr1a
T3940	20427-20433	UBERON:0004905	denotes	joints
T3941	20441-20453	UBERON:0004454	denotes	ankle region
T3942	20469-20479	_FRAGMENT	denotes	generation
T3943	20495-20497	_FRAGMENT	denotes	of
T3944	20508-20517	GO:0051216	denotes	cartilage
T3945	20498-20517	UBERON:0010996	denotes	articular cartilage
T3946	20532-20541	_FRAGMENT	denotes	joints of
T3947	20546-20550	UBERON:0003657	denotes	limb
T4595	20595-20618	UBERON:0009585	denotes	Interdigital mesenchyme
T4596	20631-20641	GO_EXT:killing	denotes	eliminated
T4597	20645-20654	GO:0006915	denotes	apoptosis
T4598	20662-20671	UBERON:0000922	denotes	embryonic
T4599	20662-20683	GO:0009790	denotes	embryonic development
T4600	20721-20724	PR_EXT:000000034	denotes	BMP
T4601	20745-20751	PR_EXT:000000021	denotes	Noggin
T4602	20771-20781	GO:0010467	denotes	expression
T4603	20803-20806	PR_EXT:000000034	denotes	BMP
T4604	20803-20816	GO_EXT:0098821	denotes	BMP receptors
T4605	20912-20917	UBERON:0002101	denotes	Limbs
T4606	20921-20925	PR_EXT:000000281	denotes	Gdf5
T4607	20930-20936	PR_EXT:000000035	denotes	Bmpr1a
T4608	20936-20941	SO:0000359	denotes	floxP
T4609	20942-20948	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4611	20985-21005	UBERON:0006015	denotes	interdigital webbing
T4612	21018-21023	_FRAGMENT	denotes	first
T4613	21051-21060	_FRAGMENT	denotes	digits of
T4614	21067-21076	UBERON:0001463	denotes	forelimbs
T4615	21028-21034	_FRAGMENT	denotes	second
T4616	21067-21076	UBERON:0003622	denotes	forelimbs
T4617	21174-21179	UBERON:0007023	denotes	adult
T4618	21180-21184	UBERON:0002101	denotes	limb
T4619	21210-21216	UBERON:0000479	denotes	tissue
T4620	21248-21259	UBERON:0006052	denotes	fifth digit
T4621	21292-21296	PR_EXT:000033987	denotes	LACZ
T4622	21297-21307	GO:0010467	denotes	expression
T4623	21311-21315	PR_EXT:000000281	denotes	Gdf5
T4624	21334-21341	UBERON:0000922	denotes	embryos
T4625	21367-21380	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T4626	21410-21438	UBERON:0003695	denotes	metacarpal-phalangeal joints
T4627	21451-21478	_FRAGMENT	denotes	interdigital region between
T4628	21483-21499	_FRAGMENT	denotes	first and second
T4629	21516-21522	UBERON:0006016	denotes	digits
T4630	21549-21562	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T4631	21567-21577	GO:0010467	denotes	expression
T4632	21581-21585	PR_EXT:000033987	denotes	LACZ
T4633	21641-21652	UBERON:0006052	denotes	fifth digit
T4634	21666-21703	GO_PR_EXT:DNA_nucleotidylexotransferase	denotes	Terminal deoxynucleotidyl transferase
T4635	21675-21691	CHEBI_SO_EXT:deoxyribonucleotide	denotes	deoxynucleotidyl
T4636	21713-21738	CHEBI_EXT:dUTP	denotes	deoxyuridine triphosphate
T4637	21748-21756	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeling
T4638	21777-21808	_FRAGMENT	denotes	interdigital mesenchyme between
T4639	21813-21836	UBERON:0009596	denotes	first and second digits
T4640	21864-21875	UBERON:0006052	denotes	fifth digit
T4641	21885-21895	UBERON:0003104	denotes	mesenchyme
T4642	21925-21930	GO:0016265	denotes	dying
T4643	21931-21936	CL_GO_EXT:cell	denotes	cells
T4644	21965-21971	UBERON:0000479	denotes	tissue
T4645	21991-21997	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4646	21998-22003	UBERON:0002101	denotes	limbs
T4647	22016-22030	GO_PATO_EXT:phosphorylation_process_or_quality	denotes	phosphorylated
T4648	22031-22038	CHEBI:15358	denotes	histone
T4649	22031-22041	PR_EXT:000027594	denotes	histone H3
T4650	22042-22049	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T4651	22050-22063	GO:0008283	denotes	proliferating
T4652	22064-22069	CL_GO_EXT:cell	denotes	cells
T4653	22124-22129	CL_GO_EXT:cell	denotes	cells
T4654	22143-22164	_FRAGMENT	denotes	webbed region between
T4655	22186-22192	UBERON:0006015	denotes	digits
T4656	22169-22174	_FRAGMENT	denotes	first
T4657	22186-22192	UBERON:0006048	denotes	digits
T4658	22179-22192	UBERON:0006049	denotes	second digits
T4659	22211-22220	GO:0010467	denotes	expressed
T4660	22221-22225	PR_EXT:000033987	denotes	LACZ
T4661	22229-22233	PR_EXT:000000281	denotes	Gdf5
T4662	22238-22244	PR_EXT:000000035	denotes	Bmpr1a
T4663	22244-22249	SO:0000359	denotes	floxP
T4664	22250-22256	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T4665	22257-22264	UBERON:0000922	denotes	embryos
T4666	22319-22325	PR_EXT:000000035	denotes	BMPR1A
T4667	22326-22334	GO_EXT:0004872	denotes	receptor
T4668	22335-22344	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling
T4669	22352-22373	GO:0012501	denotes	programmed cell death
T4670	22363-22367	CL_GO_EXT:cell	denotes	cell
T4671	22377-22400	UBERON:0009585	denotes	interdigital mesenchyme
T4672	22415-22425	GO_SO_EXT:sequence_rearrangement_process	denotes	recombined
T4673	22426-22431	CL_GO_EXT:cell	denotes	cells
T4674	22444-22455	GO:0008283	denotes	proliferate
T4675	22474-22480	PR_EXT:000000035	denotes	BMPR1A
T4676	22481-22490	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling
T5103	22510-22515	UBERON:0004905	denotes	Joint
T5104	22529-22542	UBERON:0004454	denotes	Ankle Regions
T5105	22547-22553	PR_EXT:000000035	denotes	Bmpr1a
T5106	22554-22558	SO_EXT:0000704	denotes	gene
T5107	22562-22571	GO:0010467	denotes	expressed
T5108	22610-22616	UBERON:0004905	denotes	joints
T5109	22654-22667	GO:0097617	denotes	hybridization
T5110	22684-22688	SO_EXT:0000704	denotes	gene
T5111	22697-22706	GO:0010467	denotes	expressed
T5112	22728-22740	UBERON:0001488	denotes	ankle joints
T5113	22757-22776	UBERON:0010996	denotes	articular cartilage
T5114	22788-22793	UBERON:0002544	denotes	digit
T5115	22794-22800	UBERON:0004905	denotes	joints
T5116	22822-22826	PR_EXT:000033987	denotes	LACZ
T5117	22864-22877	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T5118	22897-22909	UBERON:0001488	denotes	ankle joints
T5119	22996-23007	UBERON:0001488	denotes	ankle joint
T5120	23049-23054	GO:0007567	denotes	natal
T5121	23055-23061	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5122	23062-23069	NCBITaxon:33208	denotes	animals
T5123	23092-23097	UBERON:0004905	denotes	joint
T5124	23098-23104	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T5125	23105-23115	GO:0010467	denotes	expression
T5126	23164-23168	PR_EXT:000000281	denotes	Gdf5
T5127	23169-23173	SO_EXT:0000704	denotes	gene
T5128	23186-23195	GO:0010467	denotes	expressed
T5129	23212-23216	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	mark
T5130	23230-23235	UBERON:0004905	denotes	joint
T5131	23267-23271	SO_EXT:0000704	denotes	gene
T5132	23286-23294	CHEBI_PR_EXT:collagen	denotes	collagen
T5133	23295-23302	CHEBI_PR_EXT:protein	denotes	protein
T5134	23306-23315	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5135	23316-23322	GO:0031012	denotes	matrix
T5136	23324-23330	PR_EXT:000003266	denotes	Col2a1
T5137	23335-23349	GO_EXT:negative_regulation	denotes	down-regulated
T5138	23400-23406	PR_EXT:000003266	denotes	Col2a1
T5139	23448-23453	UBERON:0004905	denotes	joint
T5140	23492-23498	UBERON:0001447	denotes	tarsal
T5141	23502-23506	PR_EXT:000000281	denotes	Gdf5
T5142	23511-23517	PR_EXT:000000035	denotes	Bmpr1a
T5143	23517-23522	SO:0000359	denotes	floxP
T5144	23523-23530	SO_EXT:sequence_altered_entity	denotes	mutants
T5145	23561-23565	PR_EXT:000000281	denotes	Gdf5
T5146	23566-23576	GO:0010467	denotes	expression
T5147	23633-23638	UBERON:0004905	denotes	joint
T5148	23728-23739	UBERON:0001447	denotes	ankle bones
T5149	23747-23752	GO:0007567	denotes	natal
T5150	23753-23759	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5151	23760-23769	UBERON:0004288	denotes	skeletons
T5152	23815-23823	UBERON:0004288	denotes	skeletal
T5153	23842-23851	UBERON:0000922	denotes	embryonic
T5154	23842-23863	GO:0009790	denotes	embryonic development
T5155	23908-23913	UBERON:0004454	denotes	ankle
T5691	25430-25449	UBERON:0010996	denotes	Articular Cartilage
T5692	25459-25465	UBERON:0004905	denotes	Joints
T5693	25474-25480	UBERON:0004905	denotes	joints
T5694	25484-25490	PR_EXT:000000035	denotes	Bmpr1a
T5695	25512-25516	NCBITaxon:10088	denotes	mice
T5696	25518-25527	UBERON:0000922	denotes	embryonic
T5697	25544-25552	UBERON:0004288	denotes	skeletal
T5698	25592-25596	PR_EXT:000000281	denotes	Gdf5
T5699	25610-25623	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T5700	25654-25659	UBERON:0002544	denotes	digit
T5701	25709-25713	CL_GO_EXT:cell	denotes	cell
T5702	25709-25719	GO:0008219	denotes	cell death
T5703	25723-25727	CL_GO_EXT:cell	denotes	cell
T5704	25723-25741	GO:0008283	denotes	cell proliferation
T5705	25763-25784	_FRAGMENT	denotes	metacarpal-phalangeal
T5706	25810-25816	UBERON:0003695	denotes	joints
T5707	25788-25816	UBERON:0003696	denotes	metatarsal-phalangeal joints
T5708	25881-25885	PR_EXT:000033987	denotes	LACZ
T5709	25886-25896	GO:0010467	denotes	expression
T5710	25918-25940	UBERON:0006658	denotes	interphalangeal joints
T5711	25949-25958	UBERON:0004905	denotes	articular
T5713	26025-26031	PR_EXT:000003266	denotes	Col2a1
T5714	26033-26037	PR_EXT:000000281	denotes	Gdf5
T5715	26042-26048	PR_EXT:000000036	denotes	Bmpr1b
T5716	26065-26074	UBERON:0004905	denotes	articular
T5717	26090-26099	UBERON:0003221	denotes	phalanges
T5718	26139-26144	GO:0007567	denotes	birth
T5719	26146-26151	UBERON:0002544	denotes	digit
T5720	26152-26158	UBERON:0004905	denotes	joints
T5721	26214-26221	NCBITaxon:33208	denotes	animals
T5722	26223-26235	CL:0000138	denotes	chondrocytes
T5723	26253-26262	UBERON:0004905	denotes	articular
T5724	26302-26311	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5725	26312-26318	GO:0031012	denotes	matrix
T5726	26380-26393	CHEBI:37396	denotes	proteoglycans
T5727	26426-26435	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T5728	26440-26446	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5729	26447-26452	CL_GO_EXT:cell	denotes	cells
T5730	26456-26465	UBERON:0004905	denotes	articular
T5731	26479-26488	GO:0010467	denotes	expressed
T5732	26504-26510	PR_EXT:000003266	denotes	Col2a1
T5733	26515-26523	PR_EXT:000003606	denotes	Aggrecan
T5734	26525-26528	PR_EXT:000003606	denotes	Agg
T5735	26535-26540	SO_EXT:0000704	denotes	genes
T5736	26541-26549	SO_EXT:sequence_coding_function	denotes	encoding
T5737	26571-26579	CHEBI_PR_EXT:protein	denotes	proteins
T5738	26583-26592	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5739	26593-26599	GO:0031012	denotes	matrix
T5740	26657-26665	CL_GO_EXT:cell	denotes	cellular
T5741	26657-26675	GO:0006915	denotes	cellular apoptosis
T5742	26657-26665	_FRAGMENT	denotes	cellular
T5743	26679-26692	GO:0008283	denotes	proliferation
T5744	28016-28025	UBERON:0004905	denotes	articular
T5745	28026-28031	CL_GO_EXT:cell	denotes	cells
T5746	28059-28066	SO_EXT:sequence_altered_entity	denotes	mutants
T5747	28085-28095	GO:0010467	denotes	expression
T5748	28099-28109	PR_EXT:000010208	denotes	Matrilin-4
T5749	28111-28115	PR_EXT:000010208	denotes	Mat4
T5750	28120-28124	SO_EXT:0000704	denotes	gene
T5751	28125-28134	GO:0010467	denotes	expressed
T5752	28159-28168	UBERON:0004905	denotes	articular
T5753	28177-28185	UBERON_EXT:cartilage_element_or_tissue	denotes	chondral
T5754	28208-28214	UBERON:0004905	denotes	joints
T5755	28256-28262	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5756	28263-28270	NCBITaxon:33208	denotes	animals
T5757	28272-28285	GO_EXT:transcription	denotes	transcription
T5758	28289-28293	PR_EXT:000010208	denotes	Mat4
T5759	28324-28343	UBERON:0010996	denotes	articular cartilage
T5760	28354-28361	PATO_UBERON_EXT:neonate_or_newborn	denotes	newborn
T5761	28362-28368	UBERON:0004905	denotes	joints
T5762	28409-28419	GO:0010467	denotes	expression
T5763	28423-28427	PR_EXT:000033987	denotes	LACZ
T5764	28439-28448	UBERON:0004905	denotes	articular
T5765	28485-28498	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T5766	28527-28536	UBERON:0004905	denotes	articular
T5767	28635-28641	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T5768	28642-28646	SO_EXT:0000704	denotes	gene
T5769	28642-28657	GO:0010467	denotes	gene expression
T5770	28680-28686	PR_EXT:000000035	denotes	Bmpr1a
T5771	28719-28728	_FRAGMENT	denotes	formation
T5772	28746-28748	_FRAGMENT	denotes	of
T5773	28759-28768	GO:0051216	denotes	cartilage
T5774	28749-28768	UBERON:0010996	denotes	articular cartilage
T5775	28784-28789	GO:0007567	denotes	birth
T5776	28839-28848	UBERON:0004905	denotes	articular
T5777	28860-28866	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5778	28867-28874	NCBITaxon:33208	denotes	animals
T5779	28880-28890	GO:0010467	denotes	expression
T5780	28894-28900	PR_EXT:000003266	denotes	Col2a1
T5781	28928-28937	UBERON:0004905	denotes	articular
T5782	28954-28961	UBERON:0001435	denotes	carpals
T5783	28963-28974	UBERON:0002374	denotes	metacarpals
T5784	28980-28989	UBERON:0003221	denotes	phalanges
T5785	28997-29005	UBERON:0002398	denotes	forefeet
T5786	29067-29076	UBERON:0004905	denotes	articular
T5787	29077-29082	CL_GO_EXT:cell	denotes	cells
T5788	29086-29093	UBERON:0001447	denotes	tarsals
T5789	29098-29109	UBERON:0001448	denotes	metatarsals
T5790	29117-29125	UBERON:0002387	denotes	hindfeet
T5791	29162-29168	PR_EXT:000003266	denotes	Col2a1
T5792	29169-29179	GO:0010467	denotes	expression
T5793	29200-29205	CL_GO_EXT:cell	denotes	cells
T5794	29213-29222	UBERON:0004905	denotes	articular
T5795	29336-29346	GO:0010467	denotes	expression
T5796	29350-29353	PR_EXT:000003606	denotes	Agg
T5797	29362-29367	SO_EXT:0000704	denotes	genes
T5798	29377-29386	GO:0010467	denotes	expressed
T5799	29402-29421	UBERON:0010996	denotes	articular cartilage
T5800	29402-29427	CL:1001607	denotes	articular cartilage cells
T5801	29422-29427	CL_GO_EXT:cell	denotes	cells
T5802	29429-29437	CHEBI_PR_EXT:collagen	denotes	Collagen
T5803	29429-29439	PR_EXT:000003328	denotes	Collagen 3
T5804	29441-29447	PR_EXT:000003328	denotes	Col3a1
T5805	29453-29461	CHEBI_PR_EXT:collagen	denotes	Collagen
T5806	29453-29464	PR_EXT:000005693	denotes	Collagen 10
T5807	29466-29473	PR_EXT:000005693	denotes	Col10a1
T5808	29540-29543	PR_EXT:000000034	denotes	BMP
T5809	29540-29553	GO:0030509	denotes	BMP signaling
T5810	29566-29578	CL:0000138	denotes	chondrocytes
T5811	29618-29626	CHEBI_PR_EXT:collagen	denotes	Collagen
T5812	29618-29628	PR_EXT:000003263	denotes	Collagen 1
T5813	29630-29636	PR_EXT:000003264	denotes	Col1a1
T5814	29638-29648	GO:0010467	denotes	expression
T5815	29659-29672	GO:0008283	denotes	proliferation
T5816	29688-29693	CL_GO_EXT:cell	denotes	cells
T5817	29710-29720	CL:0000057	denotes	fibroblast
T5818	29803-29813	GO:0010467	denotes	expression
T5819	29817-29823	PR_EXT:000003264	denotes	Col1a1
T5820	29827-29833	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5821	29834-29853	UBERON:0010996	denotes	articular cartilage
T5822	29862-29875	GO:0008283	denotes	proliferation
T5823	29892-29901	UBERON:0004905	denotes	articular
T5824	29902-29907	CL_GO_EXT:cell	denotes	cells
T5825	29918-29924	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5826	29936-29943	NCBITaxon:33208	denotes	animals
T5827	29970-29980	GO_SO_EXT:sequence_rearrangement_process	denotes	recombined
T5828	29981-29985	PR_EXT:000033987	denotes	LACZ
T5829	29986-29992	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T5830	29993-30003	GO:0010467	denotes	expression
T5831	30025-30044	UBERON:0010996	denotes	articular cartilage
T5832	30025-30050	CL:1001607	denotes	articular cartilage cells
T5833	30045-30050	CL_GO_EXT:cell	denotes	cells
T5834	30089-30098	UBERON:0004905	denotes	articular
T5835	30099-30111	CL:0000138	denotes	chondrocytes
T5836	30113-30119	GO_EXT:biological_growth_entity_or_process	denotes	growth
T5837	30113-30125	UBERON:0002516	denotes	growth plate
T5838	30126-30138	CL:0000138	denotes	chondrocytes
T5839	30144-30155	CL:0000062	denotes	osteoblasts
T5840	30222-30225	PR_EXT:000000034	denotes	BMP
T5841	30222-30235	GO:0030509	denotes	BMP signaling
T5842	30262-30266	CL_GO_EXT:cell	denotes	cell
T5843	30316-30335	UBERON:0010996	denotes	articular cartilage
T5844	30350-30361	PR_EXT:000030444	denotes	Osteocalcin
T5845	30366-30372	PR_EXT:000003264	denotes	Col1a1
T5846	30373-30383	GO:0010467	denotes	expression
T5847	30403-30414	CL:0000062	denotes	osteoblasts
T5848	30469-30475	PR_EXT:000000035	denotes	BMPR1A
T5849	30504-30509	GO:0007567	denotes	natal
T5850	30510-30515	UBERON:0004905	denotes	joint
T5851	30516-30535	UBERON:0010996	denotes	articular cartilage
T5852	30548-30558	GO:0010467	denotes	expression
T5853	30567-30572	SO_EXT:0000704	denotes	genes
T5854	30573-30581	SO_EXT:sequence_coding_function	denotes	encoding
T5855	30607-30616	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5856	30617-30623	GO:0031012	denotes	matrix
T5857	30658-30662	PR_EXT:000015435	denotes	Sox9
T5858	30686-30695	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5859	30696-30711	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T5860	30717-30727	GO:0010467	denotes	expression
T5861	30731-30740	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5862	30741-30761	GO:0031012	denotes	extracellular matrix
T5863	30746-30754	CL_GO_EXT:cell	denotes	cellular
T5864	30763-30766	GO:0031012	denotes	ECM
T5865	30768-30773	SO_EXT:0000704	denotes	genes
T5866	30784-30787	PR_EXT:000003606	denotes	Agg
T5867	30805-30820	GO_EXT:transcription	denotes	transcriptional
T5868	30821-30830	GO_EXT:regulator	denotes	regulator
T5869	30842-30851	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5870	30852-30858	GO:0031012	denotes	matrix
T5871	30859-30863	SO_EXT:0000704	denotes	gene
T5872	30864-30870	PR_EXT:000003266	denotes	Col2a1
T5873	30974-30984	GO:0010467	denotes	expression
T5874	30993-31002	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T5875	31003-31009	GO:0031012	denotes	matrix
T5876	31010-31016	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T5877	31017-31022	SO_EXT:0000704	denotes	genes
T5878	31026-31032	PR_EXT:000000035	denotes	Bmpr1a
T5879	31033-31039	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T5880	31040-31044	NCBITaxon:10088	denotes	mice
T5881	31050-31054	PR_EXT:000015435	denotes	SOX9
T5882	31055-31062	CHEBI_PR_EXT:protein	denotes	protein
T5883	31095-31104	UBERON:0004905	denotes	articular
T5884	31147-31154	PATO_UBERON_EXT:neonate_or_newborn	denotes	newborn
T5885	31189-31193	NCBITaxon:10088	denotes	mice
T6825	31234-31242	UBERON:0007616	denotes	Synovial
T6826	31256-31265	UBERON_EXT:cartilage_element_or_tissue	denotes	Cartilage
T6827	31291-31300	UBERON_EXT:cartilage_element_or_tissue	denotes	Cartilage
T6828	31301-31311	GO_PATO_EXT:biological_maturation	denotes	Maturation
T6829	31332-31338	PR_EXT:000000035	denotes	Bmpr1a
T6830	31372-31389	UBERON_EXT:synovial_membrane	denotes	synovial membrane
T6831	31397-31410	UBERON:0001484	denotes	joint capsule
T6832	31419-31425	UBERON:0004905	denotes	joints
T6833	31447-31459	UBERON:0004454	denotes	ankle region
T6834	31491-31497	UBERON:0004905	denotes	joints
T6835	31512-31529	UBERON_EXT:synovial_membrane	denotes	synovial membrane
T6836	31530-31534	GO:0040007	denotes	grew
T6837	31544-31549	UBERON:0004905	denotes	joint
T6838	31611-31630	UBERON:0010996	denotes	articular cartilage
T6839	31682-31691	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T6840	31692-31702	GO_PATO_EXT:biological_maturation	denotes	maturation
T6841	31717-31727	GO:0010467	denotes	expression
T6842	31731-31738	PR_EXT:000005693	denotes	Col10a1
T6843	31766-31778	CL:0000138	denotes	chondrocytes
T6844	31794-31803	UBERON:0004905	denotes	articular
T6845	31902-31909	PR_EXT:000005693	denotes	Col10a1
T6846	31910-31920	GO:0010467	denotes	expression
T6847	31987-32000	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T6848	32021-32031	GO:0010467	denotes	expression
T6849	32035-32042	PR_EXT:000005693	denotes	Col10a1
T6850	32073-32077	PR_EXT:000033987	denotes	LACZ
T6851	32087-32092	CL_GO_EXT:cell	denotes	cells
T6852	32113-32122	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T6853	32139-32151	GO:0001503	denotes	ossification
T6854	32139-32157	UBERON:0006773	denotes	ossification front
T6855	32165-32172	PR_EXT:000005693	denotes	Col10a1
T6856	32185-32194	GO:0010467	denotes	expressed
T6857	32198-32206	GO_PATO_EXT:biological_maturation	denotes	maturing
T6858	32207-32216	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T6859	32207-32222	CL:0000138	denotes	cartilage cells
T6860	32217-32222	CL_GO_EXT:cell	denotes	cells
T6861	32258-32277	UBERON:0010996	denotes	articular cartilage
T6862	32371-32382	UBERON:0001132	denotes	parathyroid
T6863	32371-32390	CHEBI_PR_EXT:parathyroid_hormone	denotes	parathyroid hormone
T6864	32371-32406	PR_EXT:000013433	denotes	parathyroid hormone-related protein
T6865	32383-32390	CHEBI_GO_EXT:hormone	denotes	hormone
T6866	32399-32406	CHEBI_PR_EXT:protein	denotes	protein
T6867	32440-32449	UBERON:0004905	denotes	articular
T6868	32480-32490	GO_PATO_EXT:biological_maturation	denotes	maturation
T6869	32505-32514	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T6870	32575-32584	UBERON:0004905	denotes	articular
T6871	32636-32640	CL_GO_EXT:cell	denotes	cell
T6872	32671-32681	GO_PATO_EXT:biological_maturation	denotes	maturation
T6873	32685-32697	CL:0000138	denotes	chondrocytes
T6874	32719-32728	UBERON:0004905	denotes	articular
T6875	33814-33822	UBERON:0007616	denotes	synovial
T6876	33875-33892	CL:0000226	denotes	mononuclear cells
T6877	33879-33886	GO:0005634	denotes	nuclear
T6878	33887-33892	CL_GO_EXT:cell	denotes	cells
T6879	33904-33916	CL:0000214	denotes	synoviocytes
T6880	33920-33931	CL:0000235	denotes	macrophages
T6881	33933-33937	CL_GO_EXT:cell	denotes	cell
T6882	33988-33995	GO:0009986	denotes	surface
T6883	33996-34003	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T6884	34017-34022	GO:0007567	denotes	natal
T6885	34043-34054	CL:0000775	denotes	neutrophils
T6886	34102-34114	GO_PATO_EXT:inflammatory_process_or_quality	denotes	inflammation
T6887	34132-34140	UBERON:0007616	denotes	synovial
T6888	34214-34222	UBERON:0007616	denotes	synovial
T6889	34238-34247	GO:0065007	denotes	regulated
T6890	34251-34254	PR_EXT:000000034	denotes	BMP
T6891	34251-34264	GO:0030509	denotes	BMP signaling
T6892	34281-34289	UBERON:0007616	denotes	synovium
T6893	34312-34320	GO_EXT:reaction_or_response	denotes	response
T6894	34331-34339	UBERON:0004288	denotes	skeletal
T6895	34396-34403	UBERON:0001447	denotes	tarsals
T6896	34422-34441	UBERON:0010996	denotes	articular cartilage
T7400	34448-34460	GO_PATO_EXT:inflammatory_process_or_quality	denotes	inflammatory
T7401	34477-34496	UBERON:0010996	denotes	Articular Cartilage
T7402	34500-34505	UBERON:0002544	denotes	Digit
T7403	34510-34521	UBERON:0001485	denotes	Knee Joints
T7404	34537-34549	UBERON:0004454	denotes	ankle region
T7405	34603-34620	UBERON_EXT:synovial_membrane	denotes	synovial membrane
T7406	34631-34637	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7407	34638-34642	NCBITaxon:10088	denotes	mice
T7408	34716-34725	UBERON:0004905	denotes	articular
T7409	34784-34791	NCBITaxon:33208	denotes	animals
T7410	34817-34820	PR_EXT:000003606	denotes	Agg
T7411	34825-34830	PR_EXT:000005693	denotes	Col10
T7413	34862-34868	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7414	34869-34878	UBERON:0004905	denotes	articular
T7415	34894-34902	UBERON:0002398	denotes	forefeet
T7416	34907-34915	UBERON:0002387	denotes	hindfeet
T7417	34959-34968	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T7418	35040-35059	UBERON:0010996	denotes	articular cartilage
T7419	35137-35141	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7420	35205-35215	GO:0010467	denotes	expression
T7421	35219-35230	PR_EXT:000030444	denotes	Osteocalcin
T7422	35232-35238	PR_EXT:000003264	denotes	Col1a1
T7423	35243-35249	GO:0031012	denotes	matrix
T7424	35243-35268	PR_EXT:000010473	denotes	matrix metalloprotease-13
T7425	35250-35265	GO_EXT:0008237	denotes	metalloprotease
T7426	37045-37053	_FRAGMENT	denotes	joint of
T7427	37058-37066	UBERON:0003840	denotes	hindlimb
T7428	37072-37076	UBERON:0001465	denotes	knee
T7429	37134-37145	UBERON:0001487	denotes	foot joints
T7430	37151-37158	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T7431	37162-37171	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T7432	37172-37178	GO:0031012	denotes	matrix
T7433	37248-37253	UBERON:0004905	denotes	joint
T7434	37310-37315	GO:0007567	denotes	natal
T7435	37347-37353	PR_EXT:000003266	denotes	Col2a1
T7436	37358-37361	PR_EXT:000003606	denotes	Agg
T7437	37362-37372	GO:0010467	denotes	expression
T7438	37401-37407	SO_EXT:sequence_altered_entity	denotes	mutant
T7439	37427-37437	GO:0010467	denotes	expression
T7440	37441-37445	PR_EXT:000015435	denotes	Sox9
T7441	37487-37493	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7442	37494-37498	UBERON:0001465	denotes	knee
T7443	37499-37516	UBERON:0004765	denotes	skeletal elements
T7444	37560-37578	UBERON:0001995	denotes	fibrocartilaginous
T7445	37579-37587	UBERON:0000387	denotes	meniscus
T7446	37613-37618	UBERON:0000981	denotes	femur
T7447	37623-37628	UBERON:0000979	denotes	tibia
T7448	37657-37664	SO_EXT:sequence_altered_entity	denotes	mutants
T7449	37680-37689	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T7450	37704-37712	UBERON:0000387	denotes	meniscus
T7451	37795-37800	CL_GO_EXT:cell	denotes	cells
T7452	37818-37831	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilaginous
T7453	37885-37893	UBERON:0000387	denotes	meniscus
T7454	37947-37954	NCBITaxon:33208	denotes	animals
T7455	38026-38042	UBERON:0004383	denotes	tibial epiphysis
T7456	38078-38083	UBERON:0001465	denotes	knees
T7457	38087-38093	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7458	38094-38101	NCBITaxon:33208	denotes	animals
T7459	38146-38152	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7460	38146-38158	UBERON:0002516	denotes	growth plate
T7461	38163-38172	UBERON:0004905	denotes	articular
T7462	38215-38234	UBERON:0010996	denotes	Articular cartilage
T7463	38268-38275	NCBITaxon:33208	denotes	animals
T7464	38348-38356	CL_GO_EXT:cell	denotes	cellular
T7465	38453-38458	CL_GO_EXT:cell	denotes	cells
T7466	38477-38483	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7467	38484-38493	UBERON:0004905	denotes	articular
T7468	38545-38549	PR_EXT:000033987	denotes	LACZ
T7469	38559-38564	CL_GO_EXT:cell	denotes	cells
T7470	38603-38609	PR_EXT:000000035	denotes	Bmpr1a
T7471	38622-38626	CL_GO_EXT:cell	denotes	cell
T7472	38643-38662	UBERON:0010996	denotes	articular cartilage
T7473	38725-38731	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7474	38732-38737	UBERON:0001465	denotes	knees
T7475	38753-38762	UBERON:0004905	denotes	articular
T7476	38763-38768	CL_GO_EXT:cell	denotes	cells
T7477	38778-38783	UBERON:0001474	denotes	bones
T7478	38791-38796	UBERON:0000981	denotes	femur
T7479	38801-38806	UBERON:0000979	denotes	tibia
T7480	38869-38881	_FRAGMENT	denotes	epiphysis of
T7481	38886-38891	UBERON:0004383	denotes	tibia
T7482	38935-38941	GO_EXT:biological_growth_entity_or_process	denotes	growth
T7483	38935-38957	UBERON:0004129	denotes	growth plate cartilage
T7484	39004-39008	UBERON:0001474	denotes	bone
T7485	39051-39058	SO_EXT:sequence_altered_entity	denotes	mutants
T7486	39086-39094	UBERON_EXT:cartilage_element_or_tissue	denotes	chondral
T7487	39124-39136	_FRAGMENT	denotes	epiphysis of
T7488	39141-39146	UBERON:0004384	denotes	femur
T7489	39196-39204	UBERON_EXT:cartilage_element_or_tissue	denotes	chondral
T7490	39321-39329	GO_EXT:reaction_or_response	denotes	response
T7491	39333-39337	UBERON_EXT:bone_element_or_tissue	denotes	bone
T7492	39333-39347	GO_EXT:bone_development_or_ossification	denotes	bone formation
T7493	39376-39395	UBERON:0010996	denotes	articular cartilage
T7494	39436-39442	PR_EXT:000000035	denotes	Bmpr1a
T7495	39443-39452	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling
T7496	39461-39465	PR_EXT:000033987	denotes	LACZ
T7497	39475-39480	CL_GO_EXT:cell	denotes	cells
T7498	39567-39572	UBERON:0004905	denotes	joint
T7499	39664-39670	GO_EXT:biological_movement_or_translocation_process	denotes	motion
T7500	39674-39680	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7501	39681-39688	NCBITaxon:33208	denotes	animals
T7502	39690-39694	PR_EXT:000000281	denotes	Gdf5
T7503	39699-39705	PR_EXT:000000035	denotes	Bmpr1a
T7504	39705-39710	SO:0000359	denotes	floxP
T7505	39711-39717	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7506	39718-39725	NCBITaxon:33208	denotes	animals
T7507	39869-39876	SO_EXT:sequence_altered_entity	denotes	mutants
T7508	39907-39913	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	Mutant
T7509	39914-39918	NCBITaxon:10088	denotes	mice
T7510	39998-40004	UBERON:0004905	denotes	joints
T7511	40012-40018	UBERON:0002544	denotes	digits
T7512	40056-40058	UBERON:0001448	denotes	MT
T7513	40059-40061	UBERON:0004302	denotes	P1
T7514	40062-40067	UBERON:0004905	denotes	joint
T7515	40096-40103	SO_EXT:sequence_altered_entity	denotes	mutants
T7516	40132-40134	UBERON:0004302	denotes	P1
T7517	40135-40137	UBERON:4100005	denotes	P2
T7518	40138-40143	UBERON:0004905	denotes	joint
T7519	40172-40179	SO_EXT:sequence_altered_entity	denotes	mutants
T7520	40238-40244	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T7521	40245-40249	SO_EXT:0000704	denotes	gene
T7522	40245-40260	GO:0010467	denotes	gene expression
T7523	40288-40294	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T7524	40295-40299	NCBITaxon:10088	denotes	mice
T7525	40317-40323	PR_EXT:000000035	denotes	BMPR1A
T7526	40351-40356	GO:0007567	denotes	natal
T7527	40372-40391	UBERON:0010996	denotes	articular cartilage
T8878	40435-40438	PR_EXT:000000034	denotes	BMP
T8879	40435-40448	GO:0030509	denotes	BMP signaling
T8880	40540-40553	GO:0009790	denotes	embryogenesis
T8881	40584-40587	PR_EXT:000000034	denotes	BMP
T8882	40584-40597	GO_EXT:0098821	denotes	BMP receptors
T8883	40605-40610	GO:0016265	denotes	death
T8884	40646-40650	PR_EXT:000000281	denotes	Gdf5
T8885	40655-40668	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T8886	40695-40704	UBERON:0000922	denotes	embryonic
T8887	40705-40714	GO_EXT:fatality_or_lethality	denotes	lethality
T8888	40718-40724	PR_EXT:000000035	denotes	Bmpr1a
T8889	40725-40734	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8890	40798-40806	GO_EXT:0004872	denotes	receptor
T8891	40810-40814	UBERON:0002101	denotes	limb
T8892	40810-40814	_FRAGMENT	denotes	limb
T8893	40828-40839	GO:0060173	denotes	development
T8894	40819-40827	UBERON:0004288	denotes	skeletal
T8895	40819-40839	GO:0001501	denotes	skeletal development
T8896	40857-40861	UBERON:0002101	denotes	limb
T8897	40897-40903	PR_EXT:000000035	denotes	Bmpr1a
T8898	40909-40913	PR_EXT:000000281	denotes	Gdf5
T8899	40933-40955	UBERON:0006015	denotes	webbing between digits
T8900	40965-40970	UBERON:0004905	denotes	joint
T8901	41010-41015	UBERON:0004454	denotes	ankle
T8902	41041-41060	UBERON:0010996	denotes	articular cartilage
T8903	41067-41072	GO:0007567	denotes	birth
T8904	41154-41157	PR_EXT:000000034	denotes	BMP
T8905	41154-41167	GO:0030509	denotes	BMP signaling
T8906	41175-41187	UBERON:0006012	denotes	interdigital
T8907	41188-41197	GO:0006915	denotes	apoptosis
T8908	41205-41219	_FRAGMENT	denotes	development of
T8909	41224-41228	GO:0060173	denotes	limb
T8910	41224-41228	UBERON:0002101	denotes	limb
T8911	41288-41291	PR_EXT:000000034	denotes	BMP
T8912	41288-41309	GO:0030509	denotes	BMP signaling pathway
T8913	41470-41473	PR_EXT:000000034	denotes	BMP
T8914	41470-41483	GO:0030509	denotes	BMP signaling
T8915	41500-41512	UBERON:0006012	denotes	interdigital
T8916	41513-41522	GO:0006915	denotes	apoptosis
T8917	41541-41547	PR_EXT:000000035	denotes	Bmpr1a
T8918	41622-41628	PR_EXT:000000035	denotes	Bmpr1a
T8919	41679-41684	UBERON:0004905	denotes	joint
T8920	41738-41743	UBERON:0004905	denotes	joint
T8921	41758-41766	_FRAGMENT	denotes	bones in
T8922	41771-41776	UBERON:0001447	denotes	ankle
T8923	41778-41787	SO_EXT:sequence_alteration_entity_or_process	denotes	Mutations
T8924	41805-41812	CHEBI_GO_EXT:ligand	denotes	ligands
T8925	41820-41823	PR_EXT:000000034	denotes	BMP
T8926	41832-41836	PR_EXT:000000281	denotes	Gdf5
T8927	41841-41845	PR_EXT:000007924	denotes	Gdf6
T8928	41851-41857	PR_EXT:000000036	denotes	Bmpr1b
T8929	41858-41866	GO_EXT:0004872	denotes	receptor
T8930	41879-41884	NCBITaxon:9606	denotes	human
T8931	41885-41891	PR_EXT:000000021	denotes	Noggin
T8932	42020-42025	UBERON:0004905	denotes	joint
T8933	42065-42070	UBERON:0002101	denotes	limbs
T8934	42076-42081	UBERON:0004905	denotes	joint
T8935	42133-42136	PR_EXT:000000034	denotes	BMP
T8936	42133-42144	GO:0030509	denotes	BMP pathway
T8937	42174-42177	PR_EXT:000000034	denotes	BMP
T8938	42174-42187	GO:0030509	denotes	BMP signaling
T8939	42220-42225	UBERON:0004905	denotes	joint
T8940	42244-42254	UBERON:0001062	denotes	anatomical
T8941	42271-42277	UBERON:0004905	denotes	joints
T8942	42303-42309	PR_EXT:000000035	denotes	Bmpr1a
T8943	42328-42332	PR_EXT:000000281	denotes	Gdf5
T8944	42333-42343	GO:0010467	denotes	expression
T8945	42365-42370	UBERON:0004905	denotes	joint
T8946	42391-42403	UBERON:0004454	denotes	ankle region
T8947	42451-42454	PR_EXT:000000034	denotes	BMP
T8948	42451-42464	GO:0030509	denotes	BMP signaling
T8949	42478-42484	UBERON:0004905	denotes	joints
T8950	42502-42512	GO:0010467	denotes	expression
T8951	42522-42525	PR_EXT:000000034	denotes	BMP
T8952	42522-42535	GO_EXT:0098821	denotes	BMP receptors
T8953	42548-42554	UBERON:0004454	denotes	ankles
T8954	42600-42604	PR_EXT:000000281	denotes	Gdf5
T8955	42620-42624	SO_EXT:0000704	denotes	gene
T8956	42641-42647	UBERON:0004454	denotes	ankles
T8957	42658-42663	UBERON:0004905	denotes	joint
T8958	42691-42701	GO:0010467	denotes	expression
T8959	42709-42714	PR_EXT:P05187	denotes	HPLAP
T8960	42715-42721	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T8961	42742-42746	PR_EXT:000000281	denotes	Gdf5
T8962	42747-42754	GO:0065007	denotes	control
T8963	42778-42782	PR_EXT:000033987	denotes	LACZ
T8964	42783-42789	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T8965	42791-42800	GO:0010467	denotes	expressed
T8966	42811-42815	PR_EXT:000000281	denotes	Gdf5
T8967	42820-42833	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T8968	42849-42862	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T8969	42885-42889	SO_EXT:0000704	denotes	gene
T8970	42885-42900	GO:0010467	denotes	gene expression
T8971	42937-42942	UBERON:0002544	denotes	digit
T8972	42990-42996	PR_EXT:000000035	denotes	Bmpr1a
T8973	42997-43001	CHEBI_SO_EXT:mRNA	denotes	mRNA
T8974	43006-43013	CHEBI_PR_EXT:protein	denotes	protein
T8975	43050-43054	PR_EXT:000000281	denotes	Gdf5
T8976	43070-43083	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T8977	43139-43145	PR_EXT:000000035	denotes	Bmpr1a
T8978	43149-43154	UBERON:0004905	denotes	joint
T8979	43198-43206	_FRAGMENT	denotes	decay of
T8980	43214-43218	GO:0006402	denotes	mRNA
T8981	43223-43230	GO:0030163	denotes	protein
T8982	43207-43213	PR_EXT:000000035	denotes	Bmpr1a
T8983	43214-43218	CHEBI_SO_EXT:mRNA	denotes	mRNA
T8984	43223-43230	CHEBI_PR_EXT:protein	denotes	protein
T8985	43236-43240	PR_EXT:000000281	denotes	Gdf5
T8986	43297-43303	PR_EXT:000000035	denotes	Bmpr1a
T8987	43316-43326	GO_SO_EXT:sequence_rearrangement_process	denotes	recombined
T8988	43327-43332	CL_GO_EXT:cell	denotes	cells
T8989	43384-43391	SO_EXT:0000704	denotes	genetic
T8990	43401-43407	PR_EXT:000000035	denotes	Bmpr1a
T8991	43436-43441	UBERON:0004905	denotes	joint
T8992	43488-43497	UBERON:0004905	denotes	articular
T8993	43510-43514	SO_EXT:0000704	denotes	gene
T8994	43510-43525	GO:0010467	denotes	gene expression
T8995	43544-43549	GO:0007567	denotes	birth
T8996	43551-43557	PR_EXT:000000035	denotes	Bmpr1a
T8997	43568-43575	NCBITaxon:33208	denotes	animals
T8998	43610-43624	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T8999	43634-43653	UBERON:0010996	denotes	articular cartilage
T9000	43686-43689	GO:0007568	denotes	age
T9001	43718-43721	PR_EXT:000000034	denotes	BMP
T9002	43718-43730	GO_EXT:0098821	denotes	BMP receptor
T9003	43718-43740	GO:0030509	denotes	BMP receptor signaling
T9004	43792-43811	UBERON:0010996	denotes	articular cartilage
T9005	43823-43828	GO:0007567	denotes	natal
T9006	43837-43856	UBERON:0010996	denotes	Articular cartilage
T9007	43879-43894	UBERON:0002217	denotes	synovial joints
T9008	43932-43940	UBERON:0004288	denotes	skeleton
T9009	43947-43956	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9010	43976-43985	UBERON:0000113	denotes	adulthood
T9011	44013-44032	UBERON:0010996	denotes	articular cartilage
T9012	44036-44041	UBERON:0004905	denotes	joint
T9013	44147-44165	UBERON:0001437	denotes	ends of long bones
T9014	44187-44206	UBERON:0010996	denotes	articular cartilage
T9015	44215-44221	PR_EXT:000000035	denotes	Bmpr1a
T9016	44291-44304	GO:0008283	denotes	proliferation
T9017	44320-44327	GO:0010467	denotes	express
T9018	44328-44334	PR_EXT:000003264	denotes	Col1a1
T9019	44353-44360	GO:0010467	denotes	express
T9020	44361-44365	PR_EXT:000015435	denotes	SOX9
T9021	44375-44388	GO_EXT:transcription	denotes	transcription
T9022	44375-44395	GO_EXT:transcription_factor	denotes	transcription factor
T9023	44396-44406	GO:0065007	denotes	regulating
T9024	44407-44417	GO:0010467	denotes	expression
T9025	44446-44455	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9026	44456-44462	GO:0031012	denotes	matrix
T9027	44528-44537	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9028	44538-44544	GO:0031012	denotes	matrix
T9029	44570-44576	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9030	44577-44584	NCBITaxon:33208	denotes	animals
T9031	44609-44621	_FRAGMENT	denotes	synthesis of
T9032	44639-44652	GO:0030166	denotes	proteoglycans
T9033	44622-44628	PR_EXT:000003266	denotes	Col2a1
T9034	44630-44633	PR_EXT:000003606	denotes	Agg
T9035	44639-44652	CHEBI:37396	denotes	proteoglycans
T9036	44665-44671	PR_EXT:000000035	denotes	BMPR1A
T9037	44692-44711	UBERON:0010996	denotes	articular cartilage
T9038	44739-44749	GO:0010467	denotes	expression
T9039	44757-44771	GO:0044420	denotes	ECM components
T9040	44800-44804	PR_EXT:000015435	denotes	SOX9
T9041	44805-44818	GO_EXT:transcription	denotes	transcription
T9042	44805-44825	GO_EXT:transcription_factor	denotes	transcription factor
T9043	44842-44851	GO:0010467	denotes	expressed
T9044	44855-44861	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9045	44862-44871	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9046	44888-44894	PR_EXT:000003266	denotes	Col2a1
T9047	44920-44933	GO_EXT:transcription	denotes	transcription
T9048	44920-44940	GO_EXT:transcription_factor	denotes	transcription factor
T9049	45013-45017	PR_EXT:000015435	denotes	SOX9
T9050	45046-45053	CHEBI_PR_EXT:protein	denotes	protein
T9051	45046-45062	GO_EXT:0004691	denotes	protein kinase A
T9052	45064-45067	GO_EXT:0004691	denotes	PKA
T9053	45079-45086	CHEBI_PR_EXT:protein	denotes	protein
T9054	45079-45102	GO:0006468	denotes	protein phosphorylation
T9055	45112-45122	GO:0010467	denotes	expression
T9056	45138-45146	CHEBI_PR_EXT:protein	denotes	proteins
T9057	45148-45154	PR_EXT:000026780	denotes	L-SOX5
T9058	45159-45163	PR_EXT:000015432	denotes	SOX6
T9059	45254-45259	SO_EXT:0000704	denotes	genes
T9060	45275-45282	NCBITaxon:9031	denotes	chicken
T9061	45283-45288	UBERON:0002544	denotes	digit
T9062	45312-45316	PR_EXT:000015435	denotes	Sox9
T9063	45345-45351	PR_EXT:000000036	denotes	Bmpr1b
T9064	45357-45363	PR_EXT:000026780	denotes	L-Sox5
T9065	45374-45378	PR_EXT:000015432	denotes	Sox6
T9066	45387-45396	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9067	45397-45403	GO:0031012	denotes	matrix
T9068	45426-45432	PR_EXT:000003266	denotes	Col2a1
T9069	45437-45440	PR_EXT:000003606	denotes	Agg
T9070	45522-45526	SO_EXT:0000704	denotes	gene
T9071	45522-45537	GO:0010467	denotes	gene expression
T9072	45550-45556	PR_EXT:000000035	denotes	Bmpr1a
T9073	45567-45571	NCBITaxon:10088	denotes	mice
T9074	45586-45592	PR_EXT:000000035	denotes	BMPR1A
T9075	45593-45602	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling
T9076	45633-45637	PR_EXT:000015435	denotes	SOX9
T9077	45641-45680	GO_SO_EXT:post_translational_modification_entity_or_process	denotes	post-translational protein modification
T9078	45660-45667	CHEBI_PR_EXT:protein	denotes	protein
T9079	45695-45701	PR_EXT:000026780	denotes	L-Sox5
T9080	45705-45709	PR_EXT:000015432	denotes	Sox6
T9081	45713-45722	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9082	45735-45745	GO:0010467	denotes	expression
T9083	45749-45763	GO:0044420	denotes	ECM components
T9084	45813-45817	PR_EXT:000000164	denotes	BMP2
T9085	45835-45838	GO_EXT:0004691	denotes	PKA
T9086	45859-45869	GO:0010467	denotes	expression
T9087	45873-45877	PR_EXT:000015432	denotes	Sox6
T9088	45881-45887	UBERON:0000479	denotes	tissue
T9089	45888-45901	CL:0000010	denotes	culture cells
T9090	45896-45901	CL_GO_EXT:cell	denotes	cells
T9091	45993-46003	GO:0010467	denotes	expression
T9092	46007-46013	PR_EXT:000026780	denotes	L-Sox5
T9093	46017-46021	PR_EXT:000015432	denotes	Sox6
T9094	46029-46034	GO:0007567	denotes	natal
T9095	46035-46054	UBERON:0010996	denotes	articular cartilage
T9096	46069-46084	GO_PATO_EXT:phosphorylation_process	denotes	phosphorylation
T9097	46094-46098	PR_EXT:000015435	denotes	SOX9
T9098	46126-46134	CHEBI_EXT:33893	denotes	reagents
T9099	46240-46245	GO:0007567	denotes	natal
T9100	46295-46299	SO_EXT:sequence_nullness	denotes	null
T9101	46300-46309	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T9102	46313-46319	PR_EXT:000026780	denotes	L-Sox5
T9103	46323-46328	PR_EXT:000015432	denotes	Sox-6
T9104	46335-46344	GO_EXT:fatality_or_lethality	denotes	lethality
T9105	46362-46367	GO:0007567	denotes	birth
T9106	46386-46395	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9107	46502-46511	GO:0065007	denotes	regulated
T9108	46515-46518	PR_EXT:000000034	denotes	BMP
T9109	46515-46528	GO:0030509	denotes	BMP signaling
T9110	46544-46548	PR_EXT:000015435	denotes	SOX9
T9111	46566-46571	SO_EXT:0000704	denotes	genes
T9112	46575-46594	UBERON:0010996	denotes	articular cartilage
T9113	46596-46604	SO_EXT:sequence_alteration_entity_or_process	denotes	Mutation
T9114	46608-46613	PR_EXT:000000365	denotes	Smad3
T9115	46617-46627	GO:0010467	denotes	expression
T9116	46649-46677	_FRAGMENT	denotes	transforming growth factor β
T9117	46686-46702	GO_PR_EXT:transforming_growth_factor_beta_receptor_type_II	denotes	type II receptor
T9118	46662-46668	GO_EXT:biological_growth_entity_or_process	denotes	growth
T9119	46679-46684	_FRAGMENT	denotes	TGF-β
T9120	46724-46743	UBERON:0010996	denotes	articular cartilage
T9121	46829-46833	PR_EXT:000000046	denotes	TGFβ
T9122	46829-46833	_FRAGMENT	denotes	TGFβ
T9123	46850-46859	GO:0007179	denotes	signaling
T9124	46846-46849	PR_EXT:000000034	denotes	BMP
T9125	46846-46859	GO:0030509	denotes	BMP signaling
T9126	46890-46909	UBERON:0010996	denotes	articular cartilage
T9127	46944-46948	UBERON_EXT:bone_element_or_tissue	denotes	bone
T9128	46979-46985	PR_EXT:000000035	denotes	Bmpr1a
T9129	46986-46992	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T9130	46993-47012	UBERON:0010996	denotes	articular cartilage
T9131	47030-47044	GO:0044420	denotes	ECM components
T9132	47077-47081	UBERON_EXT:bone_element_or_tissue	denotes	bone
T9133	47106-47110	PR_EXT:000000046	denotes	TGFβ
T9134	47106-47110	_FRAGMENT	denotes	TGFβ
T9135	47119-47128	GO:0007179	denotes	signaling
T9136	47115-47118	PR_EXT:000000034	denotes	BMP
T9137	47115-47128	GO:0030509	denotes	BMP signaling
T9138	47182-47201	UBERON:0010996	denotes	articular cartilage
T9139	47212-47216	PR_EXT:000000034	denotes	BMPs
T9140	47290-47294	UBERON_EXT:bone_element_or_tissue	denotes	bone
T9141	47290-47304	GO_EXT:bone_development_or_ossification	denotes	bone formation
T9142	47324-47343	UBERON:0010996	denotes	articular cartilage
T9143	47365-47374	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9144	47365-47384	GO:0051216	denotes	cartilage formation
T9145	47436-47446	GO:0031099	denotes	regenerate
T9146	47447-47456	UBERON_EXT:cartilage_element_or_tissue	denotes	cartilage
T9147	47468-47473	UBERON:0007023	denotes	adult
T9148	47474-47481	NCBITaxon:33208	denotes	animals
T9149	47611-47630	UBERON:0010996	denotes	articular cartilage
T9150	47656-47662	PR_EXT:000000035	denotes	BMPR1A
T9151	47686-47693	CHEBI_GO_EXT:ligand	denotes	ligands
T9152	47703-47711	CHEBI:36357	denotes	molecule
T9153	47712-47720	CHEBI_GO_EXT:agonist	denotes	agonists
T9154	47758-47766	GO_EXT:0004872	denotes	receptor
T9172	48506-48514	PATO_UBERON_EXT:juvenile_organism	denotes	juvenile
T9173	48604-48610	NCBITaxon:9606	denotes	people
T9174	48655-48659	NCBITaxon:10088	denotes	mice
T9175	48703-48707	SO_EXT:sequence_nullness	denotes	null
T9176	48708-48714	SO_EXT:0001023	denotes	allele
T9177	48718-48724	PR_EXT:000000035	denotes	Bmpr1a
T9178	48799-48817	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome regions
T9179	48873-48879	NCBITaxon:9606	denotes	humans
T9180	49008-49026	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosome regions
T9181	49035-49040	SO_EXT:0000704	denotes	genes
T9182	49041-49049	SO_EXT:sequence_coding_function	denotes	encoding
T9183	49075-49078	PR_EXT:000000034	denotes	BMP
T9184	49075-49096	GO:0030509	denotes	BMP signaling pathway
T9185	49112-49116	PR_EXT:000000166	denotes	BMP5
T9186	49117-49121	SO_EXT:0000704	denotes	gene
T9187	49125-49130	NCBITaxon:9606	denotes	human
T9188	49131-49141	GO_SO_EXT:chromosome	denotes	chromosome
T9189	49175-49180	PR_EXT:000000363	denotes	MADH1
T9190	49181-49185	SO_EXT:0000704	denotes	gene
T9191	49189-49194	NCBITaxon:9606	denotes	human
T9192	49195-49205	GO_SO_EXT:chromosome	denotes	chromosome
T9193	49268-49273	PR_EXT:000000037	denotes	BMPR2
T9194	49274-49282	GO_EXT:0004872	denotes	receptor
T9195	49286-49291	NCBITaxon:9606	denotes	human
T9196	49292-49302	GO_SO_EXT:chromosome	denotes	chromosome
T9197	49352-49357	NCBITaxon:9606	denotes	human
T9198	49417-49422	SO_EXT:0000704	denotes	genes
T9199	49500-49515	SO_EXT:0001645	denotes	genetic markers
T9200	49508-49515	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T9201	49521-49524	PR_EXT:000000034	denotes	BMP
T9202	49521-49534	GO:0030509	denotes	BMP signaling
T9203	49650-49659	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T9204	49698-49713	UBERON:0002217	denotes	synovial joints
T9205	49743-49754	SO_EXT:0000704	denotes	genetically
T9206	49764-49779	UBERON:0002217	denotes	synovial joints
T9207	49836-49846	NCBITaxon:7742	denotes	vertebrate
T9208	49864-49868	PR_EXT:000000281	denotes	Gdf5
T9209	49918-49922	SO_EXT:0000704	denotes	gene
T9210	49918-49933	GO:0010467	denotes	gene expression
T9211	49963-49972	UBERON:0004905	denotes	articular
T9212	50030-50035	SO_EXT:0000704	denotes	genes
T9213	50045-50052	UBERON:0000479	denotes	tissues
T9214	50092-50098	_FRAGMENT	denotes	floxed
T9215	50106-50110	SO_EXT:0000363	denotes	gene
T9216	50159-50169	GO:0010467	denotes	expression
T9217	50175-50179	SO_EXT:0000704	denotes	gene
T9218	50204-50210	UBERON:0004905	denotes	joints
T9219	50249-50253	SO_EXT:0000704	denotes	gene
T9220	50266-50275	UBERON:0004905	denotes	articular
T9221	50429-50435	UBERON:0004905	denotes	joints
T9222	50499-50504	UBERON:0004905	denotes	joint
T11192	50553-50557	PR_EXT:000000281	denotes	Gdf5
T11193	50562-50572	SO_EXT:transgenic_entity	denotes	transgenic
T11194	50573-50577	NCBITaxon:10088	denotes	mice
T11195	50580-50585	NCBITaxon:10088	denotes	mouse
T11196	50596-50599	SO_EXT:0000153	denotes	BAC
T11197	50653-50654	CHEBI_SO_EXT:base	denotes	b
T11198	50655-50658	SO_EXT:0000153	denotes	BAC
T11199	50668-50672	PR_EXT:000000281	denotes	Gdf5
T11200	50685-50688	SO_EXT:0000153	denotes	BAC
T11201	50693-50701	SO_EXT:sequence_alteration_process	denotes	modified
T11202	50721-50734	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T11203	50745-50752	NCBITaxon:562	denotes	E. coli
T11205	50789-50798	GO_PATO_EXT:biological_localization_process_or_quality	denotes	localized
T11206	50803-50814	GO_EXT:recombinase	denotes	recombinase
T11207	50821-50828	SO_EXT:0000155	denotes	plasmid
T11208	50869-50873	SO_EXT:0000243	denotes	IRES
T11209	50874-50879	PR_EXT:P05187	denotes	hPLAP
T11210	50886-50893	SO_EXT:0000155	denotes	plasmid
T11211	50943-50957	SO_EXT:0000318	denotes	ATG start site
T11212	50961-50965	PR_EXT:000000281	denotes	Gdf5
T11213	50987-50989	SO_EXT:0000028	denotes	bp
T11214	51003-51007	SO_EXT:0000147	denotes	exon
T11215	51011-51015	PR_EXT:000000281	denotes	Gdf5
T11216	51046-51050	PR_EXT:000000281	denotes	GDF5
T11217	51051-51058	CHEBI_PR_EXT:protein	denotes	protein
T11218	51129-51140	SO_EXT:0000006	denotes	PCR product
T11219	51170-51187	SO_EXT:0000061	denotes	restriction sites
T11220	51206-51208	SO_EXT:0000028	denotes	bp
T11221	51215-51222	SO_EXT:0001026	denotes	genomic
T11222	51223-51227	PR_EXT:000000281	denotes	Gdf5
T11223	51228-51236	SO_EXT:biological_sequence	denotes	sequence
T11224	51251-51277	SO_EXT:0000318	denotes	ATG translation start site
T11225	51255-51272	GO:0006413	denotes	translation start
T11226	51279-51293	SO_EXT:0000121	denotes	forward primer
T11227	51334-51341	SO:0001031	denotes	reverse
T11228	51410-51411	CHEBI_SO_EXT:base	denotes	b
T11229	51445-51449	SO_EXT:0000243	denotes	IRES
T11230	51450-51455	PR_EXT:P05187	denotes	hPLAP
T11231	51482-51483	CHEBI_SO_EXT:base	denotes	b
T11232	51484-51495	SO_EXT:0000006	denotes	PCR product
T11233	51547-51552	PR_EXT:P05187	denotes	hPLAP
T11234	51553-51569	GO:0006415	denotes	translation stop
T11235	51553-51574	SO_EXT:0000319	denotes	translation stop site
T11236	51576-51590	SO_EXT:0000121	denotes	forward primer
T11237	51637-51644	SO:0001031	denotes	reverse
T11238	51738-51739	CHEBI_SO_EXT:base	denotes	b
T11239	51740-51751	SO_EXT:0000006	denotes	PCR product
T11240	51774-51775	CHEBI_SO_EXT:base	denotes	b
T11241	51781-51785	PR_EXT:000000281	denotes	Gdf5
T11242	51786-51793	SO_EXT:0001026	denotes	genomic
T11243	51814-51821	_FRAGMENT	denotes	part of
T11244	51832-51836	SO_EXT:0000852	denotes	exon
T11245	51852-51858	SO_EXT:0001014	denotes	intron
T11246	51841-51851	SO_EXT:sequence_downstreamness	denotes	downstream
T11247	51864-51878	SO_EXT:0000121	denotes	forward primer
T11248	51912-51916	SO_EXT:0000147	denotes	exon
T11249	51953-51967	SO_EXT:0000132	denotes	reverse primer
T11250	51980-51982	NCBITaxon:10760	denotes	T7
T11251	51983-51991	SO_EXT:0000167	denotes	promoter
T11252	51999-52005	SO_EXT:0000440	denotes	vector
T11253	52026-52027	CHEBI_SO_EXT:base	denotes	b
T11254	52041-52047	SO:0000357	denotes	flanks
T11255	52052-52060	SO_EXT:0000188	denotes	intronic
T11256	52072-52086	SO_EXT:0000121	denotes	forward primer
T11257	52126-52133	SO:0001031	denotes	reverse
T11258	52189-52198	SO_EXT:engineered_biological_sequence	denotes	construct
T11259	52335-52341	SO_EXT:0000440	denotes	vector
T11260	52362-52375	GO_SO_EXT:sequence_rearrangement_process	denotes	recombination
T11261	52424-52427	CHEBI_SO_EXT:DNA	denotes	DNA
T11262	52428-52436	SO_EXT:biological_sequence	denotes	sequence
T11263	52482-52491	SO_EXT:engineered_biological_sequence	denotes	construct
T11264	52496-52499	SO_EXT:0000153	denotes	BAC
T11265	52500-52513	SO_EXT:sequence_alteration_entity_or_process	denotes	modifications
T11266	52555-52563	SO_EXT:sequence_alteration_process	denotes	modified
T11267	52564-52567	SO_EXT:0000153	denotes	BAC
T11268	52592-52602	SO_EXT:transgenic_entity	denotes	transgenic
T11269	52603-52610	NCBITaxon:33208	denotes	animals
T11270	52614-52623	SO_EXT:0000346	denotes	loxP site
T11271	52639-52649	SO_EXT:0000153	denotes	BAC vector
T11272	52738-52744	SO_EXT:0001026	denotes	genome
T11273	52758-52761	SO_EXT:0000153	denotes	BAC
T11274	52762-52765	CHEBI_SO_EXT:DNA	denotes	DNA
T11275	52782-52786	CHEBI:63039	denotes	CsCl
T11276	52830-52836	SO_EXT:0000667	denotes	insert
T11277	52846-52852	SO_EXT:0000440	denotes	vector
T11278	52883-52890	CHEBI:17992	denotes	sucrose
T11279	52980-52986	SO_EXT:0000440	denotes	vector
T11280	52996-52999	CHEBI_SO_EXT:DNA	denotes	DNA
T11281	53005-53010	CHEBI_SO_EXT:molecular_probe	denotes	probe
T11282	53043-53049	SO_EXT:0000667	denotes	insert
T11283	53075-53081	SO_EXT:0000440	denotes	vector
T11284	53082-53085	CHEBI_SO_EXT:DNA	denotes	DNA
T11285	53118-53124	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T11286	53132-53136	CHEBI:9754	denotes	Tris
T11287	53159-53163	CHEBI_EXT:EDTA	denotes	EDTA
T11288	53276-53282	SO_EXT:0000667	denotes	insert
T11289	53283-53286	CHEBI_SO_EXT:DNA	denotes	DNA
T11290	53333-53343	GO:0045120	denotes	pronucleus
T11291	53347-53357	GO:0009566	denotes	fertilized
T11292	53358-53362	CL:0000025	denotes	eggs
T11293	53374-53378	NCBITaxon:10088	denotes	mice
T11294	53395-53405	SO_EXT:transgenic_entity	denotes	Transgenic
T11295	53416-53426	SO_EXT:transgenic_entity	denotes	Transgenic
T11296	53435-53439	NCBITaxon:10088	denotes	mice
T11297	53482-53489	SO_EXT:0000112	denotes	primers
T11298	53581-53583	SO_EXT:0000028	denotes	bp
T11299	53626-53636	SO_EXT:0000153	denotes	BAC vector
T11300	53643-53649	SO_EXT:0000440	denotes	vector
T11301	53659-53666	SO_EXT:0000112	denotes	primers
T11302	53753-53755	SO_EXT:0000028	denotes	bp
T11303	53780-53784	PR_EXT:000000281	denotes	Gdf5
T11304	53789-53793	NCBITaxon:10088	denotes	mice
T11305	53849-53856	GO:0007618	denotes	Matings
T11306	53881-53885	PR_EXT:000033987	denotes	LACZ
T11307	53895-53899	NCBITaxon:10088	denotes	mice
T11308	53964-53968	PR_EXT:000033987	denotes	LACZ
T11309	53973-53978	PR_EXT:P05187	denotes	HPLAP
T11310	53988-53995	UBERON:0000922	denotes	embryos
T11311	54011-54018	UBERON:0000922	denotes	embryos
T11312	54096-54100	PR_EXT:000033987	denotes	LACZ
T12130	54266-54272	PR_EXT:000000035	denotes	Bmpr1a
T12131	54273-54279	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T12132	54280-54284	NCBITaxon:10088	denotes	mice
T12133	54285-54291	PR_EXT:000000035	denotes	Bmpr1a
T12134	54292-54296	SO_EXT:sequence_nullness	denotes	null
T12135	54301-54307	SO:0000359	denotes	floxed
T12136	54308-54315	SO_EXT:0001023	denotes	alleles
T12137	54432-54440	GO_EXT:breeding	denotes	breeding
T12138	54442-54446	NCBITaxon:10088	denotes	Mice
T12139	54460-54464	SO_EXT:sequence_nullness	denotes	null
T12140	54469-54475	SO:0000359	denotes	floxed
T12141	54476-54483	SO_EXT:0001023	denotes	alleles
T12142	54499-54504	GO:0007618	denotes	mated
T12143	54508-54512	PR_EXT:000000281	denotes	Gdf5
T12144	54517-54521	NCBITaxon:10088	denotes	mice
T12145	54558-54562	NCBITaxon:10088	denotes	mice
T12146	54633-54639	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T12147	54640-54647	NCBITaxon:33208	denotes	animals
T12148	54687-54694	GO:0007618	denotes	matings
T12149	54708-54716	UBERON:0004288	denotes	skeletal
T12150	54761-54765	NCBITaxon:10088	denotes	mice
T12151	54797-54801	UBERON:0001690	denotes	ears
T12152	54827-54834	NCBITaxon:33208	denotes	animals
T12153	54941-54947	UBERON:0010887	denotes	tragus
T12154	54952-54962	UBERON:0016467	denotes	antitragus
T12155	55004-55010	UBERON:0001757	denotes	pinnae
T12156	55041-55045	NCBITaxon:10088	denotes	mice
T12157	55070-55077	NCBITaxon:33208	denotes	animals
T12158	55234-55239	NCBITaxon:10088	denotes	mouse
T12159	55264-55270	GO_EXT:biological_movement_or_translocation_process	denotes	motion
T12160	55300-55302	UBERON:0001448	denotes	MT
T12161	55303-55305	UBERON:0004302	denotes	P1
T12162	55310-55312	UBERON:0004302	denotes	P1
T12163	55313-55315	UBERON:4100005	denotes	P2
T12164	55316-55322	UBERON:0004905	denotes	joints
T12165	55330-55351	UBERON:0003632	denotes	second hindlimb digit
T12166	55378-55385	NCBITaxon:33208	denotes	animals
T12167	55417-55422	UBERON:0004905	denotes	joint
T12168	55609-55616	NCBITaxon:33208	denotes	animals
T12169	55639-55643	NCBITaxon:10088	denotes	mice
T12170	55660-55666	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T12171	55667-55676	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T12172	55722-55726	PR_EXT:000000281	denotes	Gdf5
T12173	55735-55741	PR_EXT:000000035	denotes	Bmpr1a
T12174	55741-55745	SO_EXT:sequence_nullness	denotes	null
T12175	55782-55788	PR_EXT:000000035	denotes	Bmpr1a
T12176	55788-55793	SO:0000359	denotes	floxP
T12601	56561-56567	NCBITaxon:9986	denotes	rabbit
T12602	55938-55942	CL_GO_EXT:cell	denotes	Cell
T12603	55938-55948	GO:0008219	denotes	Cell death
T12604	55938-55942	_FRAGMENT	denotes	Cell
T12605	55953-55966	GO:0008283	denotes	proliferation
T12606	55974-55979	UBERON:0002101	denotes	Limbs
T12607	55985-55991	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T12608	56004-56011	NCBITaxon:33208	denotes	animals
T12609	56126-56132	UBERON:0000479	denotes	tissue
T12610	56173-56177	CL_GO_EXT:cell	denotes	Cell
T12611	56173-56183	GO:0008219	denotes	Cell Death
T12612	56199-56210	CHEBI:31624	denotes	Fluorescein
T12613	56309-56317	CHEBI:53424	denotes	Tween-20
T12614	56323-56327	NCBITaxon:9925	denotes	goat
T12615	56328-56333	UBERON:0001977	denotes	serum
T12616	56390-56396	NCBITaxon:9986	denotes	rabbit
T12617	56402-56409	CHEBI:32958	denotes	phospho
T12618	56410-56417	CHEBI:15358	denotes	histone
T12619	56410-56420	PR_EXT:000027594	denotes	histone-H3
T12620	56421-56429	GO:0042571	denotes	antibody
T12621	56437-56444	GO:0007067	denotes	Mitosis
T12622	56445-56451	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	Marker
T12623	56526-56531	CL_GO_EXT:cell	denotes	cells
T12624	56535-56542	GO:0007067	denotes	mitosis
T12625	56544-56547	CHEBI:37987	denotes	Cy3
T12626	56548-56555	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T12627	56578-56586	GO:0042571	denotes	antibody
T12628	56610-56618	GO:0042571	denotes	antibody
T12629	56620-56624	CL_GO_EXT:cell	denotes	Cell
T12630	56620-56631	GO:0005634	denotes	Cell nuclei
T12631	56637-56644	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T12632	56650-56654	CHEBI:51231	denotes	DAPI
T12633	56814-56824	UBERON:0001062	denotes	anatomical
T12634	56870-56877	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T12635	56878-56885	GO:0005634	denotes	nuclear
T12636	56914-56917	CHEBI:37987	denotes	Cy3
T12637	56918-56925	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T12638	56926-56932	GO:0005634	denotes	nuclei
T12639	57017-57023	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T12640	57024-57031	NCBITaxon:33208	denotes	animals
T12641	57047-57054	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T12642	57055-57060	CL_GO_EXT:cell	denotes	cells
T12643	57068-57089	_FRAGMENT	denotes	metacarpal-phalangeal
T12644	57116-57122	UBERON:0003695	denotes	joints
T12645	57094-57122	UBERON:0003696	denotes	metatarsal-phalangeal joints
T12646	57198-57203	UBERON:0004905	denotes	joint
T12647	57233-57244	UBERON:0006052	denotes	fifth digit
T12648	57284-57290	_FRAGMENT	denotes	tip of
T12649	57295-57300	UBERON:0009551	denotes	digit
T12650	57352-57358	UBERON:0000479	denotes	tissue
T13056	57448-57454	UBERON:0000479	denotes	Tissue
T13057	57460-57467	NCBITaxon:33208	denotes	animals
T13058	57543-57559	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T13059	57561-57564	CHEBI_EXT:paraformaldehye	denotes	PFA
T13060	57661-57668	CHEBI:17992	denotes	sucrose
T13061	57700-57707	CHEBI:17992	denotes	sucrose
T13062	57779-57785	UBERON:0000479	denotes	Tissue
T13063	57791-57798	NCBITaxon:33208	denotes	animals
T13064	57799-57803	GO_PATO_EXT:aging_or_agedness	denotes	aged
T13065	57899-57903	CHEBI_EXT:EDTA	denotes	EDTA
T13066	57944-57951	CHEBI:17992	denotes	sucrose
T13067	57957-57966	CHEBI:75958	denotes	solutions
T13068	58020-58024	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13069	58030-58037	UBERON:0000479	denotes	tissues
T13070	58053-58057	NCBITaxon:10088	denotes	mice
T13071	58104-58110	UBERON:0000479	denotes	Tissue
T13072	58196-58206	CHEBI:82468	denotes	Fast Green
T13073	58220-58231	CHEBI:51686	denotes	hematoxylin
T13074	58301-58305	PR_EXT:000033987	denotes	LACZ
T13075	58320-58325	CHEBI:75055	denotes	X-Gal
T13076	58407-58410	CHEBI_EXT:paraformaldehye	denotes	PFA
T13077	58435-58440	CHEBI:15377	denotes	water
T13078	58463-58470	GO:0005634	denotes	Nuclear
T13079	58508-58513	CHEBI:15377	denotes	water
T13080	58608-58611	CHEBI_SO_EXT:RNA	denotes	RNA
T13081	58620-58633	GO:0097617	denotes	hybridization
T13082	58739-58750	MOP:0000030	denotes	acetylation
T13083	58798-58808	GO_EXT:0008233	denotes	proteinase
T13084	58916-58919	CHEBI_EXT:paraformaldehye	denotes	PFA
T13085	58959-58972	GO:0097617	denotes	hybridization
T13086	58999-59015	UBERON:0005291	denotes	embryonic tissue
T13087	59060-59063	CHEBI:60004	denotes	mix
T13088	59084-59090	CHEBI_SO_EXT:molecular_probe	denotes	Probes
T13089	59109-59114	SO_EXT:0000704	denotes	genes
T13090	59147-59153	PR_EXT:000000035	denotes	Bmpr1a
T13091	59177-59183	PR_EXT:000003266	denotes	Col2a1
T13092	59210-59217	PR_EXT:000005693	denotes	Col10a1
T13093	59238-59242	PR_EXT:000000281	denotes	Gdf5
T13094	59270-59281	PR_EXT:000030444	denotes	Osteocalcin
T13095	59309-59313	PR_EXT:000015431	denotes	Sox5
T13096	59318-59322	PR_EXT:000015432	denotes	Sox6
T13097	59361-59366	CHEBI_SO_EXT:molecular_probe	denotes	probe
T13098	59389-59392	PR_EXT:000003606	denotes	Agg
T13099	59411-59419	OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process	denotes	Genetics
T13100	59431-59435	PR_EXT:000000164	denotes	Bmp2
T13101	59440-59444	PR_EXT:000000165	denotes	Bmp4
T13102	59480-59486	PR_EXT:000003264	denotes	Col1a1
T13103	59525-59531	PR_EXT:000000036	denotes	Bmpr1b
T13104	59533-59539	PR_EXT:000003328	denotes	Col3a1
T13105	59545-59549	PR_EXT:000010208	denotes	Mat4
T13106	59550-59556	CHEBI_SO_EXT:molecular_probe	denotes	probes
T13107	59572-59576	SO_EXT:0000345	denotes	ESTs
T13108	59588-59593	SO_EXT:sequence_cloned_entity	denotes	clone
T13109	59746-59749	CHEBI_EXT:paraformaldehye	denotes	PFA
T13110	59795-59801	NCBITaxon:27592	denotes	bovine
T13111	59976-59993	CHEBI:16240	denotes	hydrogen peroxide
T13112	60002-60010	CHEBI:17790	denotes	methanol
T13113	60056-60063	CHEBI:53424	denotes	Tween20
T13114	60069-60073	NCBITaxon:9925	denotes	goat
T13115	60083-60089	NCBITaxon:27592	denotes	bovine
T13116	60090-60095	UBERON:0001977	denotes	serum
T13117	60138-60148	GO:0042571	denotes	antibodies
T13118	60164-60172	CHEBI:53424	denotes	Tween 20
T13119	60178-60182	NCBITaxon:9925	denotes	goat
T13120	60192-60198	NCBITaxon:27592	denotes	bovine
T13121	60199-60204	UBERON:0001977	denotes	serum
T13122	60224-60230	CHEBI:15956	denotes	Biotin
T13123	60231-60238	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T13124	60249-60259	GO:0042571	denotes	antibodies
T13125	60279-60285	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	tagged
T13126	60398-60408	GO:0042571	denotes	antibodies
T13127	60434-60438	NCBITaxon:9925	denotes	goat
T13128	60444-60449	NCBITaxon:10088	denotes	mouse
T13129	60450-60455	PR_EXT:000010473	denotes	MMP13
T13130	60526-60532	NCBITaxon:9986	denotes	rabbit
T13131	60538-60543	NCBITaxon:9606	denotes	human
T13132	60544-60548	PR_EXT:000015435	denotes	SOX9
T13133	60587-60593	NCBITaxon:9986	denotes	rabbit
T13134	60599-60613	GO_PATO_EXT:phosphorylation_process_or_quality	denotes	phosphorylated
T13135	60614-60618	PR_EXT:000015435	denotes	SOX9
T13136	60620-60624	PR_EXT:000015435	denotes	SOX9
T4610	20949-20956	UBERON:0000922	denotes	embryos
T11204	50781-50788	GO:0005634	denotes	nuclear
T7412	34831-34841	GO:0010467	denotes	expression
T5712	26011-26021	GO:0010467	denotes	expression
T9155	47860-47879	UBERON:0010996	denotes	articular cartilage
T9156	47887-47892	GO:0007567	denotes	natal
T9157	47909-47915	PR_EXT:000000035	denotes	Bmpr1a
T9158	47928-47947	UBERON:0010996	denotes	articular cartilage
T9159	47986-47995	UBERON:0004905	denotes	articular
T9160	48016-48021	UBERON:0004905	denotes	joint
T9161	48080-48086	PR_EXT:000000035	denotes	Bmpr1a
T9162	48097-48101	NCBITaxon:10088	denotes	mice
T9163	48141-48144	PR_EXT:000000034	denotes	BMP
T9164	48141-48154	GO:0030509	denotes	BMP signaling
T9165	48174-48179	NCBITaxon:9606	denotes	human
T9166	48180-48185	UBERON:0004905	denotes	joint
T9167	48241-48248	SO_EXT:0000704	denotes	genetic
T9168	48292-48299	SO_EXT:0000704	denotes	genetic
T9169	48408-48414	NCBITaxon:9606	denotes	Humans
T9170	48458-48467	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T9171	48471-48477	PR_EXT:000000035	denotes	BMPR1A
R5	T175	T174	_lexicallyChainedTo	genes,floxed
R6	T221	T220	_lexicallyChainedTo	of,development
R7	T222	T221	_lexicallyChainedTo	tissues,of
R8	T222	T223	_lexicallyChainedTo	tissues,creation of
R2406	T3913	T3912	_lexicallyChainedTo	digits of,webbing between
R2407	T3913	T3915	_lexicallyChainedTo	digits of,first
R2408	T3914	T3913	_lexicallyChainedTo	feet,digits of
R2409	T3916	T3913	_lexicallyChainedTo	feet,digits of
R2410	T3918	T3917	_lexicallyChainedTo	feet,second digits of
R2411	T3943	T3942	_lexicallyChainedTo	of,generation
R2412	T3944	T3943	_lexicallyChainedTo	cartilage,of
R2413	T3947	T3946	_lexicallyChainedTo	limb,joints of
R2937	T4613	T4612	_lexicallyChainedTo	digits of,first
R2938	T4613	T4615	_lexicallyChainedTo	digits of,second
R2939	T4614	T4613	_lexicallyChainedTo	forelimbs,digits of
R2940	T4616	T4613	_lexicallyChainedTo	forelimbs,digits of
R2941	T4628	T4627	_lexicallyChainedTo	first and second,interdigital region between
R2942	T4629	T4628	_lexicallyChainedTo	digits,first and second
R2943	T4639	T4638	_lexicallyChainedTo	first and second digits,interdigital mesenchyme between
R2944	T4655	T4654	_lexicallyChainedTo	digits,webbed region between
R2945	T4657	T4656	_lexicallyChainedTo	digits,first
R3547	T5706	T5705	_lexicallyChainedTo	joints,metacarpal-phalangeal
R3548	T5743	T5742	_lexicallyChainedTo	proliferation,cellular
R4699	T7427	T7426	_lexicallyChainedTo	hindlimb,joint of
R4700	T7481	T7480	_lexicallyChainedTo	tibia,epiphysis of
R4701	T7488	T7487	_lexicallyChainedTo	femur,epiphysis of
R7264	T11244	T11243	_lexicallyChainedTo	exon,part of
R7265	T11245	T11243	_lexicallyChainedTo	intron,part of
R8316	T12605	T12604	_lexicallyChainedTo	proliferation,Cell
R8317	T12644	T12643	_lexicallyChainedTo	joints,metacarpal-phalangeal
R8318	T12649	T12648	_lexicallyChainedTo	digit,tip of
R356	T993	T992	_lexicallyChainedTo	mesenchymal cells,condensing
R357	T1008	T1007	_lexicallyChainedTo	formation,bone
R358	T1026	T1025	_lexicallyChainedTo	formation,bone
R359	T1080	T1079	_lexicallyChainedTo	BMP signaling pathway,modulation of
R1420	T2499	T2498	_lexicallyChainedTo	formation,embryonic
R1421	T2586	T2585	_lexicallyChainedTo	limbs,joints of
R1422	T2637	T2636	_lexicallyChainedTo	brain,regions of
R1423	T2638	T2636	_lexicallyChainedTo	spinal cord,regions of
R1424	T2655	T2654	_lexicallyChainedTo	long bones,growth plate of
R1425	T2657	T2656	_lexicallyChainedTo	brain,portions of
R1426	T2658	T2656	_lexicallyChainedTo	spinal cord,portions of
R3549	T5772	T5771	_lexicallyChainedTo	of,formation
R3550	T5773	T5772	_lexicallyChainedTo	cartilage,of
R5520	T8893	T8892	_lexicallyChainedTo	development,limb
R5521	T8909	T8908	_lexicallyChainedTo	limb,development of
R5522	T8922	T8921	_lexicallyChainedTo	ankle,bones in
R5523	T8980	T8979	_lexicallyChainedTo	mRNA,decay of
R5524	T8981	T8979	_lexicallyChainedTo	protein,decay of
R5525	T9032	T9031	_lexicallyChainedTo	proteoglycans,synthesis of
R5526	T9117	T9116	_lexicallyChainedTo	type II receptor,transforming growth factor β
R5527	T9117	T9119	_lexicallyChainedTo	type II receptor,TGF-β
R5528	T9123	T9122	_lexicallyChainedTo	signaling,TGFβ
R5529	T9135	T9134	_lexicallyChainedTo	signaling,TGFβ
R5530	T9215	T9214	_lexicallyChainedTo	gene,floxed

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T64	0-3	PR:000000034	denotes	BMP
T65	0-22	GO:0030509	denotes	BMP Receptor Signaling
T66	43-48	GO:0007567	denotes	natal
T67	64-83	UBERON:0010996	denotes	Articular Cartilage
T68	128-147	UBERON:0010996	denotes	Articular cartilage
T69	245-251	NCBITaxon:9606	denotes	people
T70	382-387	UBERON:0001474	denotes	bones
T71	391-396	UBERON:0004905	denotes	joint
T72	464-468	SO:0000704	denotes	gene
T73	464-479	GO:0010467	denotes	gene expression
T74	501-507	UBERON:0000479	denotes	tissue
T75	545-555	GO:0065007	denotes	regulatory
T76	577-582	NCBITaxon:10088	denotes	mouse
T77	583-587	PR:000000281	denotes	Gdf5
T78	588-592	SO:0000704	denotes	gene
T79	596-614	GO:0060349	denotes	bone morphogenetic
T80	596-622	PR:000000034	denotes	bone morphogenetic protein
T81	624-627	PR:000000034	denotes	BMP
T82	659-664	NCBITaxon:10088	denotes	mouse
T83	721-726	SO:0000704	denotes	genes
T84	754-760	UBERON:0004905	denotes	joints
T85	762-772	GO:0010467	denotes	Expression
T86	797-801	PR:000000281	denotes	Gdf5
T87	802-811	NCBITaxon:2	denotes	bacterial
T88	802-833	SO:0000153	denotes	bacterial artificial chromosome
T89	889-895	_FRAGMENT	denotes	floxed
T90	903-908	SO:0000363	denotes	genes
T91	923-929	UBERON:0004905	denotes	joints
T92	947-952	UBERON:0004905	denotes	joint
T93	965-970	UBERON:0007023	denotes	adult
T94	971-990	UBERON:0010996	denotes	articular cartilage
T95	1000-1013	UBERON:0001484	denotes	joint capsule
T96	1060-1063	PR:000000034	denotes	BMP
T97	1060-1082	GO:0030509	denotes	BMP receptor signaling
T98	1086-1091	UBERON:0004905	denotes	joint
T99	1105-1109	NCBITaxon:10088	denotes	Mice
T100	1133-1139	PR:000000035	denotes	Bmpr1a
T101	1153-1156	GO:0016265	denotes	die
T102	1166-1179	GO:0009790	denotes	embryogenesis
T103	1224-1230	SO:0000359	denotes	floxed
T104	1231-1237	PR:000000035	denotes	Bmpr1a
T105	1238-1244	SO:0001023	denotes	allele
T106	1254-1258	PR:000000281	denotes	Gdf5
T107	1284-1293	UBERON:0000922	denotes	embryonic
T108	1318-1323	GO:0007567	denotes	birth
T109	1332-1337	GO:0007567	denotes	natal
T110	1353-1357	NCBITaxon:10088	denotes	mice
T111	1370-1376	PR:000000035	denotes	Bmpr1a
T112	1377-1381	SO:0000704	denotes	gene
T113	1385-1394	UBERON:0004905	denotes	articular
T114	1409-1415	UBERON:0004905	denotes	joints
T115	1460-1466	PR:000000035	denotes	Bmpr1a
T116	1495-1514	UBERON:0010996	denotes	articular cartilage
T117	1526-1532	UBERON:0004905	denotes	joints
T118	1576-1580	NCBITaxon:10088	denotes	mice
T119	1587-1592	GO:0007567	denotes	birth
T120	1617-1622	NCBITaxon:9606	denotes	human
T121	1639-1643	PR:000000281	denotes	Gdf5
T122	1648-1652	NCBITaxon:10088	denotes	mice
T123	1715-1720	SO:0000704	denotes	genes
T124	1724-1733	UBERON:0004905	denotes	articular
T125	1743-1746	PR:000000034	denotes	BMP
T126	1743-1765	GO:0030509	denotes	BMP receptor signaling
T127	1797-1808	_FRAGMENT	denotes	development
T128	1822-1824	_FRAGMENT	denotes	of
T129	1834-1841	GO:0009888	denotes	tissues
T130	1813-1824	_FRAGMENT	denotes	creation of
T131	1834-1841	UBERON:0000479	denotes	tissues
T132	1879-1898	UBERON:0010996	denotes	articular cartilage
T133	1905-1910	GO:0007567	denotes	birth
T134	1912-1919	SO:0000704	denotes	Genetic
T135	1949-1952	PR:000000034	denotes	BMP
T136	1949-1971	GO:0030509	denotes	BMP receptor signaling
T137	2007-2012	NCBITaxon:9606	denotes	human
T138	2066-2069	PR:000000034	denotes	BMP
T139	2066-2088	GO:0030509	denotes	BMP receptor signaling
T140	2177-2182	UBERON:0004905	denotes	joint
T722	2393-2412	UBERON:0010996	denotes	articular cartilage
T723	2422-2427	UBERON:0001474	denotes	bones
T724	2431-2446	UBERON:0002217	denotes	synovial joints
T725	2582-2601	UBERON:0010996	denotes	articular cartilage
T726	2700-2706	UBERON:0007023	denotes	adults
T727	2738-2744	NCBITaxon:9606	denotes	people
T728	2819-2825	NCBITaxon:9606	denotes	people
T729	2961-2980	UBERON:0010996	denotes	articular cartilage
T730	3022-3027	UBERON:0004905	denotes	joint
T731	3079-3084	UBERON:0004905	denotes	Joint
T732	3109-3122	GO:0009790	denotes	embryogenesis
T733	3199-3207	UBERON:0004288	denotes	skeletal
T734	3234-3255	GO:0012501	denotes	Programmed cell death
T735	3409-3414	UBERON:0004905	denotes	joint
T736	3433-3441	UBERON:0004288	denotes	skeleton
T737	3656-3675	UBERON:0010996	denotes	articular cartilage
T738	3696-3701	UBERON:0004905	denotes	joint
T739	3840-3845	UBERON:0004905	denotes	joint
T740	3857-3862	PR:000017452	denotes	Wnt14
T741	3866-3875	GO:0010467	denotes	expressed
T742	3906-3912	UBERON:0004905	denotes	joints
T743	3954-3964	GO:0010467	denotes	expression
T744	3974-3979	UBERON:0004905	denotes	joint
T745	3996-4005	GO:0010467	denotes	expressed
T746	4030-4034	UBERON:0002101	denotes	limb
T747	4085-4103	GO:0060349	denotes	bone morphogenetic
T748	4085-4111	PR:000000034	denotes	bone morphogenetic protein
T749	4113-4116	PR:000000034	denotes	BMP
T750	4128-4136	GO:0046903	denotes	secreted
T751	4137-4156	CHEBI:62488	denotes	signaling molecules
T752	4166-4175	GO:0010467	denotes	expressed
T753	4202-4208	UBERON:0004905	denotes	joints
T754	4251-4256	SO:0000704	denotes	genes
T755	4257-4261	PR:000000281	denotes	Gdf5
T756	4263-4267	PR:000007924	denotes	Gdf6
T757	4269-4273	PR:000000282	denotes	Gdf7
T758	4275-4279	PR:000000164	denotes	Bmp2
T759	4285-4289	PR:000000165	denotes	Bmp4
T760	4394-4398	PR:000000281	denotes	Gdf5
T761	4399-4409	GO:0010467	denotes	expression
T762	4454-4460	UBERON:0004905	denotes	joints
T763	4518-4523	UBERON:0004905	denotes	joint
T764	4555-4559	PR:000000281	denotes	Gdf5
T765	4583-4587	PR:000007924	denotes	Gdf6
T766	4588-4592	SO:0000704	denotes	gene
T767	4617-4623	UBERON:0004905	denotes	joints
T768	4684-4693	CHEBI:36357	denotes	molecules
T769	4716-4721	UBERON:0004905	denotes	joint
T770	4803-4807	PR:000000164	denotes	Bmp2
T771	4811-4815	PR:000000165	denotes	Bmp4
T772	4822-4837	UBERON:0019248	denotes	early embryonic
T773	4891-4896	UBERON:0004905	denotes	joint
T774	5063-5068	UBERON:0007023	denotes	adult
T775	5069-5074	UBERON:0004905	denotes	joint
T776	5100-5103	PR:000000034	denotes	BMP
T777	5100-5113	GO:0030509	denotes	BMP signaling
T778	5140-5145	UBERON:0007023	denotes	adult
T779	5146-5165	UBERON:0010996	denotes	articular cartilage
T780	5380-5384	PR:000000034	denotes	BMPs
T781	5401-5413	GO:0043235	denotes	complexes of
T782	5446-5454	GO:0016020	denotes	membrane
T783	5479-5488	GO:0043235	denotes	receptors
T784	5495-5498	PR:000000034	denotes	BMP
T785	5514-5523	GO:0032991	denotes	complexes
T786	5680-5683	PR:000000034	denotes	BMP
T787	5704-5712	UBERON:0004288	denotes	skeletal
T788	5725-5731	PR:000000035	denotes	BMPR1A
T789	5736-5742	PR:000000036	denotes	BMPR1B
T790	5768-5772	PR:000000164	denotes	BMP2
T791	5774-5778	PR:000000165	denotes	BMP4
T792	5784-5788	PR:000000281	denotes	GDF5
T793	5799-5803	PR:000000281	denotes	GDF5
T794	5830-5836	PR:000000036	denotes	BMPR1B
T795	5969-5978	GO:0010467	denotes	expressed
T796	6029-6034	UBERON:0002101	denotes	limbs
T797	6036-6042	PR:000000035	denotes	Bmpr1a
T798	6043-6053	GO:0010467	denotes	expression
T799	6076-6081	UBERON:0004905	denotes	joint
T800	6094-6107	UBERON:0002222	denotes	perichondrium
T801	6113-6122	UBERON:0004905	denotes	articular
T802	6134-6159	CL:0000743	denotes	hypertrophic chondrocytes
T803	6165-6193	UBERON:0009585	denotes	interdigital limb mesenchyme
T804	6210-6216	PR:000000036	denotes	Bmpr1b
T805	6217-6227	GO:0010467	denotes	expression
T806	6249-6259	_FRAGMENT	denotes	condensing
T807	6277-6294	CL:0000335	denotes	mesenchymal cells
T808	6277-6288	UBERON:0003104	denotes	mesenchymal
T809	6313-6318	UBERON:0004905	denotes	joint
T810	6331-6344	UBERON:0002222	denotes	perichondrium
T811	6354-6363	UBERON:0004905	denotes	articular
T812	6474-6480	PR:000000036	denotes	Bmpr1b
T813	6481-6485	SO:0000704	denotes	gene
T814	6501-6505	NCBITaxon:10088	denotes	mice
T815	6531-6536	UBERON:0004905	denotes	joint
T816	6583-6587	NCBITaxon:10088	denotes	mice
T817	6596-6600	PR:000000281	denotes	Gdf5
T818	6680-6686	PR:000000035	denotes	Bmpr1a
T819	6699-6708	UBERON:0000922	denotes	embryonic
T820	6736-6748	GO:0007369	denotes	gastrulation
T821	6774-6778	NCBITaxon:10088	denotes	mice
T822	6797-6801	PR:000000165	denotes	Bmp4
T823	6866-6872	SO:0000359	denotes	floxed
T824	6873-6880	SO:0001023	denotes	alleles
T825	6894-6900	PR:000000035	denotes	Bmpr1a
T826	6981-6986	UBERON:0004905	denotes	joint
T827	7040-7047	SO:0000704	denotes	genetic
T828	7086-7091	SO:0000704	denotes	genes
T829	7108-7113	UBERON:0004905	denotes	joint
T830	7114-7121	UBERON:0000479	denotes	tissues
T831	7174-7179	UBERON:0004905	denotes	joint
T832	7237-7243	UBERON:0000479	denotes	tissue
T833	7253-7263	GO:0010467	denotes	expression
T834	7279-7283	PR:000000281	denotes	Gdf5
T835	7284-7288	SO:0000704	denotes	gene
T836	7307-7311	SO:0000346	denotes	loxP
T837	7332-7336	PR:000000281	denotes	Gdf5
T838	7384-7391	GO:0010467	denotes	express
T839	7392-7397	SO:0000704	denotes	genes
T840	7401-7407	UBERON:0004905	denotes	joints
T841	7429-7433	NCBITaxon:10088	denotes	mice
T842	7480-7485	SO:0000704	denotes	genes
T843	7525-7539	UBERON:0002217	denotes	synovial joint
T844	7555-7564	UBERON:0000211	denotes	ligaments
T845	7572-7585	UBERON:0001484	denotes	joint capsule
T846	7618-7637	UBERON:0010996	denotes	articular cartilage
T847	7639-7643	PR:000000281	denotes	Gdf5
T848	7675-7690	UBERON:0019248	denotes	early embryonic
T849	7722-7728	PR:000000035	denotes	Bmpr1a
T850	7781-7786	UBERON:0004905	denotes	joint
T851	7837-7858	GO:0012501	denotes	programmed cell death
T852	7862-7884	UBERON:0006015	denotes	webbing between digits
T853	7901-7907	PR:000000035	denotes	Bmpr1a
T854	7933-7938	GO:0007567	denotes	natal
T855	7954-7973	UBERON:0010996	denotes	articular cartilage
T856	7997-8005	UBERON:0004288	denotes	skeleton
T857	8010-8014	PR:000000281	denotes	Gdf5
T858	8019-8025	PR:000000035	denotes	Bmpr1a
T859	8025-8030	SO:0000359	denotes	floxP
T860	8031-8035	NCBITaxon:10088	denotes	mice
T861	8037-8056	UBERON:0010996	denotes	articular cartilage
T862	8106-8116	GO:0010467	denotes	expression
T863	8156-8161	GO:0007567	denotes	birth
T864	8294-8297	PR:000000034	denotes	BMP
T865	8294-8307	GO:0030509	denotes	BMP signaling
T866	8350-8355	GO:0007567	denotes	natal
T867	8356-8375	UBERON:0010996	denotes	articular cartilage
T868	8386-8399	_FRAGMENT	denotes	modulation of
T869	8404-8425	GO:0030510	denotes	BMP signaling pathway
T870	8404-8407	PR:000000034	denotes	BMP
T871	8456-8461	UBERON:0004905	denotes	joint
T2315	8481-8488	SO:0000704	denotes	Genetic
T2316	8524-8529	SO:0000704	denotes	Genes
T2317	8533-8538	UBERON:0004905	denotes	Joint
T2318	8612-8617	SO:0000704	denotes	genes
T2319	8635-8649	UBERON:0000982	denotes	skeletal joint
T2320	8688-8692	NCBITaxon:10088	denotes	mice
T2321	8696-8703	GO:0010467	denotes	express
T2322	8734-8740	UBERON:0004905	denotes	joints
T2323	8753-8757	PR:000000281	denotes	Gdf5
T2324	8763-8767	SO:0000704	denotes	gene
T2325	8777-8786	GO:0010467	denotes	expressed
T2326	8816-8833	UBERON:0004765	denotes	skeletal elements
T2327	8841-8850	UBERON:0000922	denotes	embryonic
T2328	8841-8850	_FRAGMENT	denotes	embryonic
T2329	8857-8866	GO:0009790	denotes	formation
T2330	8851-8856	UBERON:0004905	denotes	joint
T2331	8870-8879	NCBITaxon:2	denotes	bacterial
T2332	8870-8901	SO:0000153	denotes	bacterial artificial chromosome
T2333	8903-8906	SO:0000153	denotes	BAC
T2334	8923-8927	PR:000000281	denotes	Gdf5
T2335	8978-8986	NCBITaxon:2	denotes	bacteria
T2336	8999-9007	SO:0005853	denotes	cassette
T2337	9021-9049	SO:0000243	denotes	internal ribosome entry site
T2338	9030-9038	GO:0005840	denotes	ribosome
T2339	9051-9055	SO:0000243	denotes	IRES
T2340	9057-9062	NCBITaxon:9606	denotes	human
T2341	9063-9072	UBERON:0001987	denotes	placental
T2342	9063-9093	PR:000003969	denotes	placental alkaline phosphatase
T2343	9095-9100	PR:P05187	denotes	hPLAP
T2344	9111-9128	GO:0006413	denotes	translation start
T2345	9111-9133	SO:0000318	denotes	translation start site
T2346	9137-9141	PR:000000281	denotes	Gdf5
T2347	9169-9172	SO:0000153	denotes	BAC
T2348	9215-9219	NCBITaxon:10088	denotes	mice
T2349	9235-9239	PR:000000281	denotes	Gdf5
T2350	9255-9259	NCBITaxon:10088	denotes	mice
T2351	9276-9285	SO:0000902	denotes	transgene
T2352	9286-9296	GO:0010467	denotes	expression
T2353	9360-9364	NCBITaxon:10088	denotes	mice
T2354	9383-9393	GO:0010467	denotes	expression
T2355	9397-9401	PR:000033987	denotes	lacZ
T2356	9432-9462	SO:0000616	denotes	transcriptional stop sequences
T2357	9524-9534	GO:0010467	denotes	expression
T2358	9542-9551	SO:0000902	denotes	transgene
T2359	9564-9569	PR:P05187	denotes	HPLAP
T2360	9620-9624	PR:000033987	denotes	LACZ
T2361	9682-9686	PR:000033987	denotes	LACZ
T2362	9687-9697	GO:0010467	denotes	expression
T2363	9711-9717	UBERON:0004905	denotes	joints
T2364	9745-9750	PR:P05187	denotes	HPLAP
T2365	9751-9761	GO:0010467	denotes	expression
T2366	9784-9789	UBERON:0004905	denotes	joint
T2367	9814-9819	PR:P05187	denotes	HPLAP
T2368	9820-9830	GO:0010467	denotes	expression
T2369	9838-9842	PR:000000281	denotes	Gdf5
T2370	9935-9939	PR:000033987	denotes	LACZ
T2371	9940-9950	GO:0010467	denotes	expression
T2372	9984-9990	UBERON:0004905	denotes	joints
T2373	9998-10004	UBERON:0002544	denotes	digits
T2374	10084-10088	PR:000000281	denotes	Gdf5
T2375	10093-10102	SO:0000902	denotes	transgene
T2376	10103-10112	GO:0010467	denotes	expresses
T2377	10172-10177	UBERON:0004905	denotes	joint
T2378	11857-11861	NCBITaxon:10088	denotes	mice
T2379	11880-11884	PR:000033987	denotes	lacZ
T2380	11919-11923	NCBITaxon:10088	denotes	mice
T2381	11963-11967	PR:000033987	denotes	lacZ
T2382	12006-12012	UBERON:0004905	denotes	Joints
T2383	12027-12032	UBERON:0002101	denotes	limbs
T2384	12090-12104	UBERON:0016884	denotes	shoulder joint
T2385	12124-12135	UBERON:0001490	denotes	elbow joint
T2386	12178-12183	UBERON:0004905	denotes	joint
T2387	12375-12380	UBERON:0004905	denotes	joint
T2388	12400-12405	UBERON:0002101	denotes	limbs
T2389	12407-12411	PR:000033987	denotes	LACZ
T2390	12432-12441	UBERON:0000922	denotes	embryonic
T2391	12480-12486	UBERON:0004905	denotes	joints
T2392	12502-12510	UBERON:0001467	denotes	shoulder
T2393	12515-12519	UBERON:0001465	denotes	knee
T2394	12550-12554	PR:000033987	denotes	LACZ
T2395	12555-12565	GO:0010467	denotes	expression
T2396	12611-12620	_FRAGMENT	denotes	joints of
T2397	12625-12630	UBERON:0003657	denotes	limbs
T2398	12708-12718	GO:0010467	denotes	expression
T2399	12724-12730	UBERON:0000922	denotes	embryo
T2400	12734-12740	UBERON:0000922	denotes	embryo
T2401	12765-12772	UBERON:0000922	denotes	embryos
T2402	12807-12817	UBERON:0009552	denotes	fingertips
T2403	12841-12847	UBERON:0000922	denotes	embryo
T2404	12898-12904	UBERON:0000922	denotes	embryo
T2405	12953-12959	UBERON:0004905	denotes	joints
T2406	12970-12974	PR:000033987	denotes	LACZ
T2407	13052-13062	GO:0010467	denotes	expression
T2408	13066-13070	PR:000033987	denotes	LACZ
T2409	13089-13094	UBERON:0004905	denotes	joint
T2410	13176-13186	UBERON:0001485	denotes	knee joint
T2411	13213-13230	UBERON:0006658	denotes	phalangeal joints
T2412	13282-13290	UBERON:0004288	denotes	skeleton
T2413	13305-13315	GO:0010467	denotes	expression
T2414	13319-13323	PR:000033987	denotes	LACZ
T2415	13355-13361	UBERON:0004905	denotes	joints
T2416	13439-13444	GO:0007567	denotes	natal
T2417	13445-13460	UBERON:0002217	denotes	synovial joints
T2418	13475-13494	UBERON:0010996	denotes	articular cartilage
T2419	13496-13509	UBERON:0001484	denotes	joint capsule
T2420	13628-13638	GO:0010467	denotes	expression
T2421	13642-13646	PR:000000281	denotes	Gdf5
T2422	13675-13684	UBERON:0000922	denotes	embryonic
T2423	13675-13696	GO:0009790	denotes	embryonic development
T2424	13724-13729	UBERON:0007023	denotes	Adult
T2425	13730-13740	GO:0010467	denotes	expression
T2426	13757-13761	PR:000000281	denotes	Gdf5
T2427	13762-13766	SO:0000704	denotes	gene
T2428	13802-13806	PR:000000281	denotes	Gdf5
T2429	13807-13817	GO:0010467	denotes	expression
T2430	13850-13855	UBERON:0007023	denotes	adult
T2431	13856-13875	UBERON:0010996	denotes	articular cartilage
T2432	15401-15412	UBERON:0003657	denotes	limb joints
T2433	15436-15440	PR:000033987	denotes	lacZ
T2434	15441-15451	GO:0010467	denotes	expression
T2435	15472-15476	PR:000033987	denotes	LACZ
T2436	15541-15549	UBERON:0004347	denotes	limb bud
T2437	15573-15577	PR:000033987	denotes	LACZ
T2438	15619-15629	UBERON:0001757	denotes	ear pinnae
T2439	15631-15635	UBERON:0002228	denotes	ribs
T2440	15637-15644	UBERON:0000975	denotes	sternum
T2441	15646-15653	UBERON:0000479	denotes	tissues
T2442	15661-15665	UBERON:0001456	denotes	face
T2443	15676-15686	_FRAGMENT	denotes	regions of
T2444	15691-15696	UBERON:0002616	denotes	brain
T2445	15701-15712	UBERON:0001948	denotes	spinal cord
T2446	15748-15753	GO:0007567	denotes	birth
T2447	15755-15759	PR:000033987	denotes	LACZ
T2448	15768-15777	GO:0010467	denotes	expressed
T2449	15781-15788	UBERON:0000043	denotes	tendons
T2450	15807-15823	UBERON:0001130	denotes	vertebral column
T2451	15836-15843	UBERON:0000043	denotes	tendons
T2452	15851-15856	UBERON:0004452	denotes	wrist
T2453	15861-15866	UBERON:0004454	denotes	ankle
T2454	15877-15883	UBERON:0000043	denotes	tendon
T2455	15943-15947	PR:000033987	denotes	LACZ
T2456	15956-15965	GO:0010467	denotes	expressed
T2457	15973-15987	UBERON:0002073	denotes	hair follicles
T2458	15989-16002	UBERON:0001867	denotes	ear cartilage
T2459	16022-16037	_FRAGMENT	denotes	growth plate of
T2460	16042-16052	UBERON:0002516	denotes	long bones
T2461	16058-16069	_FRAGMENT	denotes	portions of
T2462	16074-16079	UBERON:0002616	denotes	brain
T2463	16084-16095	UBERON:0001948	denotes	spinal cord
T2464	16161-16165	NCBITaxon:10088	denotes	mice
T2465	16216-16220	PR:000033987	denotes	LACZ
T2466	16221-16231	GO:0010467	denotes	expression
T2467	16276-16283	UBERON:0000479	denotes	tissues
T2468	16291-16297	NCBITaxon:33208	denotes	animal
T2469	16318-16328	GO:0010467	denotes	expression
T2470	16336-16345	SO:0000902	denotes	transgene
T2471	16368-16373	PR:P05187	denotes	HPLAP
T2472	16417-16423	UBERON:0004905	denotes	joints
T2473	16427-16434	NCBITaxon:33208	denotes	animals
T2474	16497-16501	PR:000033987	denotes	LACZ
T2475	16502-16512	GO:0010467	denotes	expression
T2476	16569-16576	NCBITaxon:33208	denotes	animals
T2477	16587-16597	GO:0010467	denotes	expression
T2478	16695-16699	PR:000033987	denotes	LACZ
T2479	16700-16710	GO:0010467	denotes	expression
T2480	16734-16741	NCBITaxon:33208	denotes	animals
T2481	16838-16845	NCBITaxon:33208	denotes	animals
T2482	16922-16927	SO:0000704	denotes	genes
T3755	17007-17011	PR:000000281	denotes	Gdf5
T3756	17016-17022	PR:000000035	denotes	Bmpr1a
T3757	17022-17027	SO:0000359	denotes	floxP
T3758	17028-17035	NCBITaxon:33208	denotes	Animals
T3759	17047-17056	UBERON:0000113	denotes	Adulthood
T3760	17062-17065	UBERON:0001690	denotes	Ear
T3761	17080-17085	UBERON:0004905	denotes	Joint
T3762	17111-17115	PR:000000281	denotes	Gdf5
T3763	17147-17150	PR:000000034	denotes	BMP
T3764	17147-17160	GO:0030509	denotes	BMP signaling
T3765	17175-17180	UBERON:0004905	denotes	joint
T3766	17194-17198	PR:000000281	denotes	Gdf5
T3767	17214-17218	NCBITaxon:10088	denotes	mice
T3768	17232-17239	NCBITaxon:33208	denotes	animals
T3769	17263-17269	SO:0000359	denotes	floxed
T3770	17270-17276	SO:0001023	denotes	allele
T3771	17284-17290	PR:000000035	denotes	Bmpr1a
T3772	17365-17371	SO:0001023	denotes	allele
T3773	17524-17528	SO:0000147	denotes	exon
T3774	17536-17542	PR:000000035	denotes	Bmpr1a
T3775	17543-17547	SO:0000704	denotes	gene
T3776	17563-17567	NCBITaxon:10088	denotes	mice
T3777	17590-17594	PR:000000281	denotes	Gdf5
T3778	17599-17608	SO:0000902	denotes	transgene
T3779	17677-17683	PR:000000035	denotes	Bmpr1a
T3780	17683-17688	SO:0000359	denotes	floxP
T3781	17689-17695	SO:0001023	denotes	allele
T3782	17710-17716	SO:0001023	denotes	allele
T3783	17724-17730	PR:000000035	denotes	Bmpr1a
T3784	17802-17806	PR:000000281	denotes	Gdf5
T3785	17811-17817	PR:000000035	denotes	Bmpr1a
T3786	17817-17822	SO:0000359	denotes	floxP
T3787	17844-17848	NCBITaxon:10088	denotes	mice
T3788	17877-17886	UBERON:0000113	denotes	adulthood
T3789	17905-17909	PR:000000281	denotes	Gdf5
T3790	17936-17951	UBERON:0019248	denotes	early embryonic
T3791	17985-17992	NCBITaxon:33208	denotes	animals
T3792	18021-18027	PR:000000035	denotes	Bmpr1a
T3793	18894-18898	PR:000000281	denotes	Gdf5
T3794	18903-18909	PR:000000035	denotes	Bmpr1a
T3795	18909-18914	SO:0000359	denotes	floxP
T3796	18915-18919	NCBITaxon:10088	denotes	mice
T3797	18979-18983	NCBITaxon:10088	denotes	mice
T3798	18996-19000	UBERON:0001690	denotes	ears
T3799	19038-19043	UBERON:0000033	denotes	heads
T3800	19140-19143	PR:000000034	denotes	BMP
T3801	19140-19153	GO:0030509	denotes	BMP signaling
T3802	19196-19208	UBERON:0001691	denotes	external ear
T3803	19212-19216	NCBITaxon:10088	denotes	mice
T3804	19284-19290	PR:000000035	denotes	Bmpr1a
T3805	19319-19322	UBERON:0001690	denotes	ear
T3806	19334-19341	GO:0010467	denotes	express
T3807	19346-19350	PR:000000281	denotes	Gdf5
T3808	19355-19364	SO:0000902	denotes	transgene
T3809	19378-19382	NCBITaxon:10088	denotes	mice
T3810	19400-19406	UBERON:0000479	denotes	tissue
T3811	19434-19449	_FRAGMENT	denotes	webbing between
T3812	19471-19480	_FRAGMENT	denotes	digits of
T3813	19487-19491	UBERON:0008439	denotes	feet
T3814	19454-19459	_FRAGMENT	denotes	first
T3815	19487-19491	UBERON:0003631	denotes	feet
T3816	19464-19480	_FRAGMENT	denotes	second digits of
T3817	19487-19491	UBERON:0003632	denotes	feet
T3818	19551-19560	UBERON:0002102	denotes	forelimbs
T3819	19585-19593	UBERON:0002398	denotes	forefeet
T3820	19621-19629	UBERON:0002387	denotes	hindfeet
T3821	19648-19655	NCBITaxon:33208	denotes	animals
T3822	19671-19679	UBERON:0004288	denotes	skeletal
T3823	19703-19711	UBERON:0004288	denotes	skeletal
T3824	19747-19753	UBERON:0004454	denotes	ankles
T3825	19755-19761	UBERON:0004905	denotes	joints
T3826	19808-19813	UBERON:0001474	denotes	bones
T3827	19864-19884	UBERON:0001453	denotes	second distal tarsal
T3828	19902-19921	UBERON:4200011	denotes	central tarsal bone
T3829	19952-19958	NCBITaxon:33208	denotes	animal
T3830	20070-20076	UBERON:0004905	denotes	joints
T3831	20152-20158	GO:0031012	denotes	matrix
T3832	20257-20266	UBERON:0004905	denotes	articular
T3833	20288-20314	UBERON:0004129	denotes	cartilaginous growth plate
T3834	20369-20375	PR:000000035	denotes	Bmpr1a
T3835	20427-20433	UBERON:0004905	denotes	joints
T3836	20441-20453	UBERON:0004454	denotes	ankle region
T3837	20469-20479	_FRAGMENT	denotes	generation
T3838	20495-20497	_FRAGMENT	denotes	of
T3839	20508-20517	GO:0051216	denotes	cartilage
T3840	20498-20517	UBERON:0010996	denotes	articular cartilage
T3841	20532-20541	_FRAGMENT	denotes	joints of
T3842	20546-20550	UBERON:0003657	denotes	limb
T4535	20595-20618	UBERON:0009585	denotes	Interdigital mesenchyme
T4536	20645-20654	GO:0006915	denotes	apoptosis
T4537	20662-20671	UBERON:0000922	denotes	embryonic
T4538	20662-20683	GO:0009790	denotes	embryonic development
T4539	20721-20724	PR:000000034	denotes	BMP
T4540	20745-20751	PR:000000021	denotes	Noggin
T4541	20771-20781	GO:0010467	denotes	expression
T4542	20803-20806	PR:000000034	denotes	BMP
T4543	20912-20917	UBERON:0002101	denotes	Limbs
T4544	20921-20925	PR:000000281	denotes	Gdf5
T4545	20930-20936	PR:000000035	denotes	Bmpr1a
T4546	20936-20941	SO:0000359	denotes	floxP
T4547	20949-20956	UBERON:0000922	denotes	embryos
T4548	20985-21005	UBERON:0006015	denotes	interdigital webbing
T4549	21018-21023	_FRAGMENT	denotes	first
T4550	21051-21060	_FRAGMENT	denotes	digits of
T4551	21067-21076	UBERON:0001463	denotes	forelimbs
T4552	21028-21034	_FRAGMENT	denotes	second
T4553	21067-21076	UBERON:0003622	denotes	forelimbs
T4554	21174-21179	UBERON:0007023	denotes	adult
T4555	21180-21184	UBERON:0002101	denotes	limb
T4556	21210-21216	UBERON:0000479	denotes	tissue
T4557	21248-21259	UBERON:0006052	denotes	fifth digit
T4558	21292-21296	PR:000033987	denotes	LACZ
T4559	21297-21307	GO:0010467	denotes	expression
T4560	21311-21315	PR:000000281	denotes	Gdf5
T4561	21334-21341	UBERON:0000922	denotes	embryos
T4562	21410-21438	UBERON:0003695	denotes	metacarpal-phalangeal joints
T4563	21451-21478	_FRAGMENT	denotes	interdigital region between
T4564	21483-21499	_FRAGMENT	denotes	first and second
T4565	21516-21522	UBERON:0006016	denotes	digits
T4566	21567-21577	GO:0010467	denotes	expression
T4567	21581-21585	PR:000033987	denotes	LACZ
T4568	21641-21652	UBERON:0006052	denotes	fifth digit
T4569	21777-21808	_FRAGMENT	denotes	interdigital mesenchyme between
T4570	21813-21836	UBERON:0009596	denotes	first and second digits
T4571	21864-21875	UBERON:0006052	denotes	fifth digit
T4572	21885-21895	UBERON:0003104	denotes	mesenchyme
T4573	21925-21930	GO:0016265	denotes	dying
T4574	21965-21971	UBERON:0000479	denotes	tissue
T4575	21998-22003	UBERON:0002101	denotes	limbs
T4576	22031-22038	CHEBI:15358	denotes	histone
T4577	22031-22041	PR:000027594	denotes	histone H3
T4578	22050-22063	GO:0008283	denotes	proliferating
T4579	22143-22164	_FRAGMENT	denotes	webbed region between
T4580	22186-22192	UBERON:0006015	denotes	digits
T4581	22169-22174	_FRAGMENT	denotes	first
T4582	22186-22192	UBERON:0006048	denotes	digits
T4583	22179-22192	UBERON:0006049	denotes	second digits
T4584	22211-22220	GO:0010467	denotes	expressed
T4585	22221-22225	PR:000033987	denotes	LACZ
T4586	22229-22233	PR:000000281	denotes	Gdf5
T4587	22238-22244	PR:000000035	denotes	Bmpr1a
T4588	22244-22249	SO:0000359	denotes	floxP
T4589	22257-22264	UBERON:0000922	denotes	embryos
T4590	22319-22325	PR:000000035	denotes	BMPR1A
T4591	22352-22373	GO:0012501	denotes	programmed cell death
T4592	22377-22400	UBERON:0009585	denotes	interdigital mesenchyme
T4593	22444-22455	GO:0008283	denotes	proliferate
T4594	22474-22480	PR:000000035	denotes	BMPR1A
T5072	22794-22800	UBERON:0004905	denotes	joints
T5073	22822-22826	PR:000033987	denotes	LACZ
T5074	22897-22909	UBERON:0001488	denotes	ankle joints
T5075	22996-23007	UBERON:0001488	denotes	ankle joint
T5076	23049-23054	GO:0007567	denotes	natal
T5077	23062-23069	NCBITaxon:33208	denotes	animals
T5078	23092-23097	UBERON:0004905	denotes	joint
T5079	23105-23115	GO:0010467	denotes	expression
T5080	23164-23168	PR:000000281	denotes	Gdf5
T5081	23169-23173	SO:0000704	denotes	gene
T5082	23186-23195	GO:0010467	denotes	expressed
T5083	23230-23235	UBERON:0004905	denotes	joint
T5084	23267-23271	SO:0000704	denotes	gene
T5085	23316-23322	GO:0031012	denotes	matrix
T5086	23324-23330	PR:000003266	denotes	Col2a1
T5087	23400-23406	PR:000003266	denotes	Col2a1
T5088	23448-23453	UBERON:0004905	denotes	joint
T5089	23492-23498	UBERON:0001447	denotes	tarsal
T5090	23502-23506	PR:000000281	denotes	Gdf5
T5091	23511-23517	PR:000000035	denotes	Bmpr1a
T5092	23517-23522	SO:0000359	denotes	floxP
T5093	23561-23565	PR:000000281	denotes	Gdf5
T5094	23566-23576	GO:0010467	denotes	expression
T5095	23633-23638	UBERON:0004905	denotes	joint
T5096	23728-23739	UBERON:0001447	denotes	ankle bones
T5097	23747-23752	GO:0007567	denotes	natal
T5098	23760-23769	UBERON:0004288	denotes	skeletons
T5099	23815-23823	UBERON:0004288	denotes	skeletal
T5100	23842-23851	UBERON:0000922	denotes	embryonic
T5101	23842-23863	GO:0009790	denotes	embryonic development
T5102	23908-23913	UBERON:0004454	denotes	ankle
T5545	25430-25449	UBERON:0010996	denotes	Articular Cartilage
T5546	25459-25465	UBERON:0004905	denotes	Joints
T5547	25474-25480	UBERON:0004905	denotes	joints
T5548	25484-25490	PR:000000035	denotes	Bmpr1a
T5549	25512-25516	NCBITaxon:10088	denotes	mice
T5550	25518-25527	UBERON:0000922	denotes	embryonic
T5551	25544-25552	UBERON:0004288	denotes	skeletal
T5552	25592-25596	PR:000000281	denotes	Gdf5
T5553	25654-25659	UBERON:0002544	denotes	digit
T5554	25709-25719	GO:0008219	denotes	cell death
T5555	25723-25741	GO:0008283	denotes	cell proliferation
T5556	25763-25784	_FRAGMENT	denotes	metacarpal-phalangeal
T5557	25810-25816	UBERON:0003695	denotes	joints
T5558	25788-25816	UBERON:0003696	denotes	metatarsal-phalangeal joints
T5559	25881-25885	PR:000033987	denotes	LACZ
T5560	25886-25896	GO:0010467	denotes	expression
T5561	25918-25940	UBERON:0006658	denotes	interphalangeal joints
T5562	25949-25958	UBERON:0004905	denotes	articular
T5563	26011-26021	GO:0010467	denotes	expression
T5564	26025-26031	PR:000003266	denotes	Col2a1
T5565	26033-26037	PR:000000281	denotes	Gdf5
T5566	26042-26048	PR:000000036	denotes	Bmpr1b
T5567	26065-26074	UBERON:0004905	denotes	articular
T5568	26090-26099	UBERON:0003221	denotes	phalanges
T5569	26139-26144	GO:0007567	denotes	birth
T5570	26146-26151	UBERON:0002544	denotes	digit
T5571	26152-26158	UBERON:0004905	denotes	joints
T5572	26214-26221	NCBITaxon:33208	denotes	animals
T5573	26223-26235	CL:0000138	denotes	chondrocytes
T5574	26253-26262	UBERON:0004905	denotes	articular
T5575	26312-26318	GO:0031012	denotes	matrix
T5576	26380-26393	CHEBI:37396	denotes	proteoglycans
T5577	26456-26465	UBERON:0004905	denotes	articular
T5578	26479-26488	GO:0010467	denotes	expressed
T5579	26504-26510	PR:000003266	denotes	Col2a1
T5580	26515-26523	PR:000003606	denotes	Aggrecan
T5581	26525-26528	PR:000003606	denotes	Agg
T5582	26535-26540	SO:0000704	denotes	genes
T5583	26593-26599	GO:0031012	denotes	matrix
T5584	26657-26675	GO:0006915	denotes	cellular apoptosis
T5585	26657-26665	_FRAGMENT	denotes	cellular
T5586	26679-26692	GO:0008283	denotes	proliferation
T5587	28016-28025	UBERON:0004905	denotes	articular
T5588	28085-28095	GO:0010467	denotes	expression
T5589	28099-28109	PR:000010208	denotes	Matrilin-4
T5590	28111-28115	PR:000010208	denotes	Mat4
T5591	28120-28124	SO:0000704	denotes	gene
T5592	28125-28134	GO:0010467	denotes	expressed
T5593	28159-28168	UBERON:0004905	denotes	articular
T5594	28208-28214	UBERON:0004905	denotes	joints
T5595	28263-28270	NCBITaxon:33208	denotes	animals
T5596	28289-28293	PR:000010208	denotes	Mat4
T5597	28324-28343	UBERON:0010996	denotes	articular cartilage
T5598	28362-28368	UBERON:0004905	denotes	joints
T5599	28409-28419	GO:0010467	denotes	expression
T5600	28423-28427	PR:000033987	denotes	LACZ
T5601	28439-28448	UBERON:0004905	denotes	articular
T5602	28527-28536	UBERON:0004905	denotes	articular
T5603	28642-28646	SO:0000704	denotes	gene
T5604	28642-28657	GO:0010467	denotes	gene expression
T5605	28680-28686	PR:000000035	denotes	Bmpr1a
T5606	28719-28728	_FRAGMENT	denotes	formation
T5607	28746-28748	_FRAGMENT	denotes	of
T5608	28759-28768	GO:0051216	denotes	cartilage
T5609	28749-28768	UBERON:0010996	denotes	articular cartilage
T5610	28784-28789	GO:0007567	denotes	birth
T5611	28839-28848	UBERON:0004905	denotes	articular
T5612	28867-28874	NCBITaxon:33208	denotes	animals
T5613	28880-28890	GO:0010467	denotes	expression
T5614	28894-28900	PR:000003266	denotes	Col2a1
T5615	28928-28937	UBERON:0004905	denotes	articular
T5616	28954-28961	UBERON:0001435	denotes	carpals
T5617	28963-28974	UBERON:0002374	denotes	metacarpals
T5618	28980-28989	UBERON:0003221	denotes	phalanges
T5619	28997-29005	UBERON:0002398	denotes	forefeet
T5620	29067-29076	UBERON:0004905	denotes	articular
T5621	29086-29093	UBERON:0001447	denotes	tarsals
T5622	29098-29109	UBERON:0001448	denotes	metatarsals
T5623	29117-29125	UBERON:0002387	denotes	hindfeet
T5624	29162-29168	PR:000003266	denotes	Col2a1
T5625	29169-29179	GO:0010467	denotes	expression
T5626	29213-29222	UBERON:0004905	denotes	articular
T5627	29336-29346	GO:0010467	denotes	expression
T5628	29350-29353	PR:000003606	denotes	Agg
T5629	29362-29367	SO:0000704	denotes	genes
T5630	29377-29386	GO:0010467	denotes	expressed
T5631	29402-29421	UBERON:0010996	denotes	articular cartilage
T5632	29402-29427	CL:1001607	denotes	articular cartilage cells
T5633	29429-29439	PR:000003328	denotes	Collagen 3
T5634	29441-29447	PR:000003328	denotes	Col3a1
T5635	29453-29464	PR:000005693	denotes	Collagen 10
T5636	29466-29473	PR:000005693	denotes	Col10a1
T5637	29540-29543	PR:000000034	denotes	BMP
T5638	29540-29553	GO:0030509	denotes	BMP signaling
T5639	29566-29578	CL:0000138	denotes	chondrocytes
T5640	29618-29628	PR:000003263	denotes	Collagen 1
T5641	29630-29636	PR:000003264	denotes	Col1a1
T5642	29638-29648	GO:0010467	denotes	expression
T5643	29659-29672	GO:0008283	denotes	proliferation
T5644	29710-29720	CL:0000057	denotes	fibroblast
T5645	29803-29813	GO:0010467	denotes	expression
T5646	29817-29823	PR:000003264	denotes	Col1a1
T5647	29834-29853	UBERON:0010996	denotes	articular cartilage
T5648	29862-29875	GO:0008283	denotes	proliferation
T5649	29892-29901	UBERON:0004905	denotes	articular
T5650	29936-29943	NCBITaxon:33208	denotes	animals
T5651	29981-29985	PR:000033987	denotes	LACZ
T5652	29993-30003	GO:0010467	denotes	expression
T5653	30025-30044	UBERON:0010996	denotes	articular cartilage
T5654	30025-30050	CL:1001607	denotes	articular cartilage cells
T5655	30089-30098	UBERON:0004905	denotes	articular
T5656	30099-30111	CL:0000138	denotes	chondrocytes
T5657	30113-30125	UBERON:0002516	denotes	growth plate
T5658	30126-30138	CL:0000138	denotes	chondrocytes
T5659	30144-30155	CL:0000062	denotes	osteoblasts
T5660	30222-30225	PR:000000034	denotes	BMP
T5661	30222-30235	GO:0030509	denotes	BMP signaling
T5662	30316-30335	UBERON:0010996	denotes	articular cartilage
T5663	30350-30361	PR:000030444	denotes	Osteocalcin
T5664	30366-30372	PR:000003264	denotes	Col1a1
T5665	30373-30383	GO:0010467	denotes	expression
T5666	30403-30414	CL:0000062	denotes	osteoblasts
T5667	30469-30475	PR:000000035	denotes	BMPR1A
T5668	30504-30509	GO:0007567	denotes	natal
T5669	30510-30515	UBERON:0004905	denotes	joint
T5670	30516-30535	UBERON:0010996	denotes	articular cartilage
T5671	30548-30558	GO:0010467	denotes	expression
T5672	30567-30572	SO:0000704	denotes	genes
T5673	30617-30623	GO:0031012	denotes	matrix
T5674	30658-30662	PR:000015435	denotes	Sox9
T5675	30717-30727	GO:0010467	denotes	expression
T5676	30741-30761	GO:0031012	denotes	extracellular matrix
T5677	30763-30766	GO:0031012	denotes	ECM
T5678	30768-30773	SO:0000704	denotes	genes
T5679	30784-30787	PR:000003606	denotes	Agg
T5680	30852-30858	GO:0031012	denotes	matrix
T5681	30859-30863	SO:0000704	denotes	gene
T5682	30864-30870	PR:000003266	denotes	Col2a1
T5683	30974-30984	GO:0010467	denotes	expression
T5684	31003-31009	GO:0031012	denotes	matrix
T5685	31017-31022	SO:0000704	denotes	genes
T5686	31026-31032	PR:000000035	denotes	Bmpr1a
T5687	31040-31044	NCBITaxon:10088	denotes	mice
T5688	31050-31054	PR:000015435	denotes	SOX9
T5689	31095-31104	UBERON:0004905	denotes	articular
T5690	31189-31193	NCBITaxon:10088	denotes	mice
T6778	31234-31242	UBERON:0007616	denotes	Synovial
T6779	31332-31338	PR:000000035	denotes	Bmpr1a
T6780	31397-31410	UBERON:0001484	denotes	joint capsule
T6781	31419-31425	UBERON:0004905	denotes	joints
T6782	31447-31459	UBERON:0004454	denotes	ankle region
T6783	31491-31497	UBERON:0004905	denotes	joints
T6784	31530-31534	GO:0040007	denotes	grew
T6785	31544-31549	UBERON:0004905	denotes	joint
T6786	31611-31630	UBERON:0010996	denotes	articular cartilage
T6787	31717-31727	GO:0010467	denotes	expression
T6788	31731-31738	PR:000005693	denotes	Col10a1
T6789	31766-31778	CL:0000138	denotes	chondrocytes
T6790	31794-31803	UBERON:0004905	denotes	articular
T6791	31902-31909	PR:000005693	denotes	Col10a1
T6792	31910-31920	GO:0010467	denotes	expression
T6793	32021-32031	GO:0010467	denotes	expression
T6794	32035-32042	PR:000005693	denotes	Col10a1
T6795	32073-32077	PR:000033987	denotes	LACZ
T6796	32139-32151	GO:0001503	denotes	ossification
T6797	32139-32157	UBERON:0006773	denotes	ossification front
T6798	32165-32172	PR:000005693	denotes	Col10a1
T6799	32185-32194	GO:0010467	denotes	expressed
T6800	32207-32222	CL:0000138	denotes	cartilage cells
T6801	32258-32277	UBERON:0010996	denotes	articular cartilage
T6802	32371-32382	UBERON:0001132	denotes	parathyroid
T6803	32371-32406	PR:000013433	denotes	parathyroid hormone-related protein
T6804	32440-32449	UBERON:0004905	denotes	articular
T6805	32575-32584	UBERON:0004905	denotes	articular
T6806	32685-32697	CL:0000138	denotes	chondrocytes
T6807	32719-32728	UBERON:0004905	denotes	articular
T6808	33814-33822	UBERON:0007616	denotes	synovial
T6809	33875-33892	CL:0000226	denotes	mononuclear cells
T6810	33879-33886	GO:0005634	denotes	nuclear
T6811	33904-33916	CL:0000214	denotes	synoviocytes
T6812	33920-33931	CL:0000235	denotes	macrophages
T6813	33988-33995	GO:0009986	denotes	surface
T6814	34017-34022	GO:0007567	denotes	natal
T6815	34043-34054	CL:0000775	denotes	neutrophils
T6816	34132-34140	UBERON:0007616	denotes	synovial
T6817	34214-34222	UBERON:0007616	denotes	synovial
T6818	34238-34247	GO:0065007	denotes	regulated
T6819	34251-34254	PR:000000034	denotes	BMP
T6820	34251-34264	GO:0030509	denotes	BMP signaling
T6821	34281-34289	UBERON:0007616	denotes	synovium
T6822	34331-34339	UBERON:0004288	denotes	skeletal
T6823	34396-34403	UBERON:0001447	denotes	tarsals
T6824	34422-34441	UBERON:0010996	denotes	articular cartilage
T7314	34477-34496	UBERON:0010996	denotes	Articular Cartilage
T7315	34500-34505	UBERON:0002544	denotes	Digit
T7316	34510-34521	UBERON:0001485	denotes	Knee Joints
T7317	34537-34549	UBERON:0004454	denotes	ankle region
T7318	34638-34642	NCBITaxon:10088	denotes	mice
T7319	34716-34725	UBERON:0004905	denotes	articular
T7320	34784-34791	NCBITaxon:33208	denotes	animals
T7321	34817-34820	PR:000003606	denotes	Agg
T7322	34825-34830	PR:000005693	denotes	Col10
T7323	34831-34841	GO:0010467	denotes	expression
T7324	34869-34878	UBERON:0004905	denotes	articular
T7325	34894-34902	UBERON:0002398	denotes	forefeet
T7326	34907-34915	UBERON:0002387	denotes	hindfeet
T7327	35040-35059	UBERON:0010996	denotes	articular cartilage
T7328	35205-35215	GO:0010467	denotes	expression
T7329	35219-35230	PR:000030444	denotes	Osteocalcin
T7330	35232-35238	PR:000003264	denotes	Col1a1
T7331	35243-35249	GO:0031012	denotes	matrix
T7332	35243-35268	PR:000010473	denotes	matrix metalloprotease-13
T7333	37045-37053	_FRAGMENT	denotes	joint of
T7334	37058-37066	UBERON:0003840	denotes	hindlimb
T7335	37072-37076	UBERON:0001465	denotes	knee
T7336	37134-37145	UBERON:0001487	denotes	foot joints
T7337	37172-37178	GO:0031012	denotes	matrix
T7338	37248-37253	UBERON:0004905	denotes	joint
T7339	37310-37315	GO:0007567	denotes	natal
T7340	37347-37353	PR:000003266	denotes	Col2a1
T7341	37358-37361	PR:000003606	denotes	Agg
T7342	37362-37372	GO:0010467	denotes	expression
T7343	37427-37437	GO:0010467	denotes	expression
T7344	37441-37445	PR:000015435	denotes	Sox9
T7345	37494-37498	UBERON:0001465	denotes	knee
T7346	37499-37516	UBERON:0004765	denotes	skeletal elements
T7347	37560-37578	UBERON:0001995	denotes	fibrocartilaginous
T7348	37579-37587	UBERON:0000387	denotes	meniscus
T7349	37613-37618	UBERON:0000981	denotes	femur
T7350	37623-37628	UBERON:0000979	denotes	tibia
T7351	37704-37712	UBERON:0000387	denotes	meniscus
T7352	37885-37893	UBERON:0000387	denotes	meniscus
T7353	37947-37954	NCBITaxon:33208	denotes	animals
T7354	38026-38042	UBERON:0004383	denotes	tibial epiphysis
T7355	38078-38083	UBERON:0001465	denotes	knees
T7356	38094-38101	NCBITaxon:33208	denotes	animals
T7357	38146-38158	UBERON:0002516	denotes	growth plate
T7358	38163-38172	UBERON:0004905	denotes	articular
T7359	38215-38234	UBERON:0010996	denotes	Articular cartilage
T7360	38268-38275	NCBITaxon:33208	denotes	animals
T7361	38484-38493	UBERON:0004905	denotes	articular
T7362	38545-38549	PR:000033987	denotes	LACZ
T7363	38603-38609	PR:000000035	denotes	Bmpr1a
T7364	38643-38662	UBERON:0010996	denotes	articular cartilage
T7365	38732-38737	UBERON:0001465	denotes	knees
T7366	38753-38762	UBERON:0004905	denotes	articular
T7367	38778-38783	UBERON:0001474	denotes	bones
T7368	38791-38796	UBERON:0000981	denotes	femur
T7369	38801-38806	UBERON:0000979	denotes	tibia
T7370	38869-38881	_FRAGMENT	denotes	epiphysis of
T7371	38886-38891	UBERON:0004383	denotes	tibia
T7372	38935-38957	UBERON:0004129	denotes	growth plate cartilage
T7373	39004-39008	UBERON:0001474	denotes	bone
T7374	39124-39136	_FRAGMENT	denotes	epiphysis of
T7375	39141-39146	UBERON:0004384	denotes	femur
T7376	39376-39395	UBERON:0010996	denotes	articular cartilage
T7377	39436-39442	PR:000000035	denotes	Bmpr1a
T7378	39461-39465	PR:000033987	denotes	LACZ
T7379	39567-39572	UBERON:0004905	denotes	joint
T7380	39681-39688	NCBITaxon:33208	denotes	animals
T7381	39690-39694	PR:000000281	denotes	Gdf5
T7382	39699-39705	PR:000000035	denotes	Bmpr1a
T7383	39705-39710	SO:0000359	denotes	floxP
T7384	39718-39725	NCBITaxon:33208	denotes	animals
T7385	39914-39918	NCBITaxon:10088	denotes	mice
T7386	39998-40004	UBERON:0004905	denotes	joints
T7387	40012-40018	UBERON:0002544	denotes	digits
T7388	40056-40058	UBERON:0001448	denotes	MT
T7389	40059-40061	UBERON:0004302	denotes	P1
T7390	40062-40067	UBERON:0004905	denotes	joint
T7391	40132-40134	UBERON:0004302	denotes	P1
T7392	40135-40137	UBERON:4100005	denotes	P2
T7393	40138-40143	UBERON:0004905	denotes	joint
T7394	40245-40249	SO:0000704	denotes	gene
T7395	40245-40260	GO:0010467	denotes	gene expression
T7396	40295-40299	NCBITaxon:10088	denotes	mice
T7397	40317-40323	PR:000000035	denotes	BMPR1A
T7398	40351-40356	GO:0007567	denotes	natal
T7399	40372-40391	UBERON:0010996	denotes	articular cartilage
T8608	40435-40438	PR:000000034	denotes	BMP
T8609	40435-40448	GO:0030509	denotes	BMP signaling
T8610	40540-40553	GO:0009790	denotes	embryogenesis
T8611	40584-40587	PR:000000034	denotes	BMP
T8612	40605-40610	GO:0016265	denotes	death
T8613	40646-40650	PR:000000281	denotes	Gdf5
T8614	40695-40704	UBERON:0000922	denotes	embryonic
T8615	40718-40724	PR:000000035	denotes	Bmpr1a
T8616	40810-40814	UBERON:0002101	denotes	limb
T8617	40810-40814	_FRAGMENT	denotes	limb
T8618	40828-40839	GO:0060173	denotes	development
T8619	40819-40827	UBERON:0004288	denotes	skeletal
T8620	40819-40839	GO:0001501	denotes	skeletal development
T8621	40857-40861	UBERON:0002101	denotes	limb
T8622	40897-40903	PR:000000035	denotes	Bmpr1a
T8623	40909-40913	PR:000000281	denotes	Gdf5
T8624	40933-40955	UBERON:0006015	denotes	webbing between digits
T8625	40965-40970	UBERON:0004905	denotes	joint
T8626	41010-41015	UBERON:0004454	denotes	ankle
T8627	41041-41060	UBERON:0010996	denotes	articular cartilage
T8628	41067-41072	GO:0007567	denotes	birth
T8629	41154-41157	PR:000000034	denotes	BMP
T8630	41154-41167	GO:0030509	denotes	BMP signaling
T8631	41175-41187	UBERON:0006012	denotes	interdigital
T8632	41188-41197	GO:0006915	denotes	apoptosis
T8633	41205-41219	_FRAGMENT	denotes	development of
T8634	41224-41228	GO:0060173	denotes	limb
T8635	41224-41228	UBERON:0002101	denotes	limb
T8636	41288-41291	PR:000000034	denotes	BMP
T8637	41288-41309	GO:0030509	denotes	BMP signaling pathway
T8638	41470-41473	PR:000000034	denotes	BMP
T8639	41470-41483	GO:0030509	denotes	BMP signaling
T8640	41500-41512	UBERON:0006012	denotes	interdigital
T8641	41513-41522	GO:0006915	denotes	apoptosis
T8642	41541-41547	PR:000000035	denotes	Bmpr1a
T8643	41622-41628	PR:000000035	denotes	Bmpr1a
T8644	41679-41684	UBERON:0004905	denotes	joint
T8645	41738-41743	UBERON:0004905	denotes	joint
T8646	41758-41766	_FRAGMENT	denotes	bones in
T8647	41771-41776	UBERON:0001447	denotes	ankle
T8648	41820-41823	PR:000000034	denotes	BMP
T8649	41832-41836	PR:000000281	denotes	Gdf5
T8650	41841-41845	PR:000007924	denotes	Gdf6
T8651	41851-41857	PR:000000036	denotes	Bmpr1b
T8652	41879-41884	NCBITaxon:9606	denotes	human
T8653	41885-41891	PR:000000021	denotes	Noggin
T8654	42020-42025	UBERON:0004905	denotes	joint
T8655	42065-42070	UBERON:0002101	denotes	limbs
T8656	42076-42081	UBERON:0004905	denotes	joint
T8657	42133-42136	PR:000000034	denotes	BMP
T8658	42133-42144	GO:0030509	denotes	BMP pathway
T8659	42174-42177	PR:000000034	denotes	BMP
T8660	42174-42187	GO:0030509	denotes	BMP signaling
T8661	42220-42225	UBERON:0004905	denotes	joint
T8662	42244-42254	UBERON:0001062	denotes	anatomical
T8663	42271-42277	UBERON:0004905	denotes	joints
T8664	42303-42309	PR:000000035	denotes	Bmpr1a
T8665	42328-42332	PR:000000281	denotes	Gdf5
T8666	42333-42343	GO:0010467	denotes	expression
T8667	42365-42370	UBERON:0004905	denotes	joint
T8668	42391-42403	UBERON:0004454	denotes	ankle region
T8669	42451-42454	PR:000000034	denotes	BMP
T8670	42451-42464	GO:0030509	denotes	BMP signaling
T8671	42478-42484	UBERON:0004905	denotes	joints
T8672	42502-42512	GO:0010467	denotes	expression
T8673	42522-42525	PR:000000034	denotes	BMP
T8674	42548-42554	UBERON:0004454	denotes	ankles
T8675	42600-42604	PR:000000281	denotes	Gdf5
T8676	42620-42624	SO:0000704	denotes	gene
T8677	42641-42647	UBERON:0004454	denotes	ankles
T8678	42658-42663	UBERON:0004905	denotes	joint
T8679	42691-42701	GO:0010467	denotes	expression
T8680	42709-42714	PR:P05187	denotes	HPLAP
T8681	42742-42746	PR:000000281	denotes	Gdf5
T8682	42747-42754	GO:0065007	denotes	control
T8683	42778-42782	PR:000033987	denotes	LACZ
T8684	42791-42800	GO:0010467	denotes	expressed
T8685	42811-42815	PR:000000281	denotes	Gdf5
T8686	42885-42889	SO:0000704	denotes	gene
T8687	42885-42900	GO:0010467	denotes	gene expression
T8688	42937-42942	UBERON:0002544	denotes	digit
T8689	42990-42996	PR:000000035	denotes	Bmpr1a
T8690	43050-43054	PR:000000281	denotes	Gdf5
T8691	43139-43145	PR:000000035	denotes	Bmpr1a
T8692	43149-43154	UBERON:0004905	denotes	joint
T8693	43198-43206	_FRAGMENT	denotes	decay of
T8694	43214-43218	GO:0006402	denotes	mRNA
T8695	43223-43230	GO:0030163	denotes	protein
T8696	43207-43213	PR:000000035	denotes	Bmpr1a
T8697	43236-43240	PR:000000281	denotes	Gdf5
T8698	43297-43303	PR:000000035	denotes	Bmpr1a
T8699	43384-43391	SO:0000704	denotes	genetic
T8700	43401-43407	PR:000000035	denotes	Bmpr1a
T8701	43436-43441	UBERON:0004905	denotes	joint
T8702	43488-43497	UBERON:0004905	denotes	articular
T8703	43510-43514	SO:0000704	denotes	gene
T8704	43510-43525	GO:0010467	denotes	gene expression
T8705	43544-43549	GO:0007567	denotes	birth
T8706	43551-43557	PR:000000035	denotes	Bmpr1a
T8707	43568-43575	NCBITaxon:33208	denotes	animals
T8708	43634-43653	UBERON:0010996	denotes	articular cartilage
T8709	43686-43689	GO:0007568	denotes	age
T8710	43718-43721	PR:000000034	denotes	BMP
T8711	43718-43740	GO:0030509	denotes	BMP receptor signaling
T8712	43792-43811	UBERON:0010996	denotes	articular cartilage
T8713	43823-43828	GO:0007567	denotes	natal
T8714	43837-43856	UBERON:0010996	denotes	Articular cartilage
T8715	43879-43894	UBERON:0002217	denotes	synovial joints
T8716	43932-43940	UBERON:0004288	denotes	skeleton
T8717	43976-43985	UBERON:0000113	denotes	adulthood
T8718	44013-44032	UBERON:0010996	denotes	articular cartilage
T8719	44036-44041	UBERON:0004905	denotes	joint
T8720	44147-44165	UBERON:0001437	denotes	ends of long bones
T8721	44187-44206	UBERON:0010996	denotes	articular cartilage
T8722	44215-44221	PR:000000035	denotes	Bmpr1a
T8723	44291-44304	GO:0008283	denotes	proliferation
T8724	44320-44327	GO:0010467	denotes	express
T8725	44328-44334	PR:000003264	denotes	Col1a1
T8726	44353-44360	GO:0010467	denotes	express
T8727	44361-44365	PR:000015435	denotes	SOX9
T8728	44396-44406	GO:0065007	denotes	regulating
T8729	44407-44417	GO:0010467	denotes	expression
T8730	44456-44462	GO:0031012	denotes	matrix
T8731	44538-44544	GO:0031012	denotes	matrix
T8732	44577-44584	NCBITaxon:33208	denotes	animals
T8733	44609-44621	_FRAGMENT	denotes	synthesis of
T8734	44639-44652	GO:0030166	denotes	proteoglycans
T8735	44622-44628	PR:000003266	denotes	Col2a1
T8736	44630-44633	PR:000003606	denotes	Agg
T8737	44639-44652	CHEBI:37396	denotes	proteoglycans
T8738	44665-44671	PR:000000035	denotes	BMPR1A
T8739	44692-44711	UBERON:0010996	denotes	articular cartilage
T8740	44739-44749	GO:0010467	denotes	expression
T8741	44757-44771	GO:0044420	denotes	ECM components
T8742	44800-44804	PR:000015435	denotes	SOX9
T8743	44842-44851	GO:0010467	denotes	expressed
T8744	44888-44894	PR:000003266	denotes	Col2a1
T8745	45013-45017	PR:000015435	denotes	SOX9
T8746	45079-45102	GO:0006468	denotes	protein phosphorylation
T8747	45112-45122	GO:0010467	denotes	expression
T8748	45148-45154	PR:000026780	denotes	L-SOX5
T8749	45159-45163	PR:000015432	denotes	SOX6
T8750	45254-45259	SO:0000704	denotes	genes
T8751	45275-45282	NCBITaxon:9031	denotes	chicken
T8752	45283-45288	UBERON:0002544	denotes	digit
T8753	45312-45316	PR:000015435	denotes	Sox9
T8754	45345-45351	PR:000000036	denotes	Bmpr1b
T8755	45357-45363	PR:000026780	denotes	L-Sox5
T8756	45374-45378	PR:000015432	denotes	Sox6
T8757	45397-45403	GO:0031012	denotes	matrix
T8758	45426-45432	PR:000003266	denotes	Col2a1
T8759	45437-45440	PR:000003606	denotes	Agg
T8760	45522-45526	SO:0000704	denotes	gene
T8761	45522-45537	GO:0010467	denotes	gene expression
T8762	45550-45556	PR:000000035	denotes	Bmpr1a
T8763	45567-45571	NCBITaxon:10088	denotes	mice
T8764	45586-45592	PR:000000035	denotes	BMPR1A
T8765	45633-45637	PR:000015435	denotes	SOX9
T8766	45646-45659	GO:0006412	denotes	translational
T8767	45695-45701	PR:000026780	denotes	L-Sox5
T8768	45705-45709	PR:000015432	denotes	Sox6
T8769	45735-45745	GO:0010467	denotes	expression
T8770	45749-45763	GO:0044420	denotes	ECM components
T8771	45813-45817	PR:000000164	denotes	BMP2
T8772	45859-45869	GO:0010467	denotes	expression
T8773	45873-45877	PR:000015432	denotes	Sox6
T8774	45881-45887	UBERON:0000479	denotes	tissue
T8775	45888-45901	CL:0000010	denotes	culture cells
T8776	45993-46003	GO:0010467	denotes	expression
T8777	46007-46013	PR:000026780	denotes	L-Sox5
T8778	46017-46021	PR:000015432	denotes	Sox6
T8779	46029-46034	GO:0007567	denotes	natal
T8780	46035-46054	UBERON:0010996	denotes	articular cartilage
T8781	46094-46098	PR:000015435	denotes	SOX9
T8782	46126-46134	CHEBI:33893	denotes	reagents
T8783	46240-46245	GO:0007567	denotes	natal
T8784	46313-46319	PR:000026780	denotes	L-Sox5
T8785	46323-46328	PR:000015432	denotes	Sox-6
T8786	46362-46367	GO:0007567	denotes	birth
T8787	46502-46511	GO:0065007	denotes	regulated
T8788	46515-46518	PR:000000034	denotes	BMP
T8789	46515-46528	GO:0030509	denotes	BMP signaling
T8790	46544-46548	PR:000015435	denotes	SOX9
T8791	46566-46571	SO:0000704	denotes	genes
T8792	46575-46594	UBERON:0010996	denotes	articular cartilage
T8793	46608-46613	PR:000000365	denotes	Smad3
T8794	46617-46627	GO:0010467	denotes	expression
T8795	46649-46677	PR:000000046	denotes	transforming growth factor β
T8796	46679-46684	PR:000000046	denotes	TGF-β
T8797	46724-46743	UBERON:0010996	denotes	articular cartilage
T8798	46829-46833	PR:000000046	denotes	TGFβ
T8799	46829-46833	_FRAGMENT	denotes	TGFβ
T8800	46850-46859	GO:0007179	denotes	signaling
T8801	46846-46849	PR:000000034	denotes	BMP
T8802	46846-46859	GO:0030509	denotes	BMP signaling
T8803	46890-46909	UBERON:0010996	denotes	articular cartilage
T8804	46979-46985	PR:000000035	denotes	Bmpr1a
T8805	46993-47012	UBERON:0010996	denotes	articular cartilage
T8806	47030-47044	GO:0044420	denotes	ECM components
T8807	47106-47110	PR:000000046	denotes	TGFβ
T8808	47106-47110	_FRAGMENT	denotes	TGFβ
T8809	47119-47128	GO:0007179	denotes	signaling
T8810	47115-47118	PR:000000034	denotes	BMP
T8811	47115-47128	GO:0030509	denotes	BMP signaling
T8812	47182-47201	UBERON:0010996	denotes	articular cartilage
T8839	48655-48659	NCBITaxon:10088	denotes	mice
T8840	48708-48714	SO:0001023	denotes	allele
T8841	48718-48724	PR:000000035	denotes	Bmpr1a
T8842	48873-48879	NCBITaxon:9606	denotes	humans
T8843	49035-49040	SO:0000704	denotes	genes
T8844	49075-49078	PR:000000034	denotes	BMP
T8845	49075-49096	GO:0030509	denotes	BMP signaling pathway
T8846	49112-49116	PR:000000166	denotes	BMP5
T8847	49117-49121	SO:0000704	denotes	gene
T8848	49125-49130	NCBITaxon:9606	denotes	human
T8849	49175-49180	PR:000000363	denotes	MADH1
T8850	49181-49185	SO:0000704	denotes	gene
T8851	49189-49194	NCBITaxon:9606	denotes	human
T8852	49268-49273	PR:000000037	denotes	BMPR2
T8853	49286-49291	NCBITaxon:9606	denotes	human
T8854	49352-49357	NCBITaxon:9606	denotes	human
T8855	49417-49422	SO:0000704	denotes	genes
T8856	49500-49515	SO:0001645	denotes	genetic markers
T8857	49521-49524	PR:000000034	denotes	BMP
T8858	49521-49534	GO:0030509	denotes	BMP signaling
T8859	49698-49713	UBERON:0002217	denotes	synovial joints
T8860	49743-49754	SO:0000704	denotes	genetically
T8861	49764-49779	UBERON:0002217	denotes	synovial joints
T8862	49836-49846	NCBITaxon:7742	denotes	vertebrate
T8863	49864-49868	PR:000000281	denotes	Gdf5
T8864	49918-49922	SO:0000704	denotes	gene
T8865	49918-49933	GO:0010467	denotes	gene expression
T8866	49963-49972	UBERON:0004905	denotes	articular
T8867	50030-50035	SO:0000704	denotes	genes
T8868	50045-50052	UBERON:0000479	denotes	tissues
T8869	50092-50098	_FRAGMENT	denotes	floxed
T8870	50106-50110	SO:0000363	denotes	gene
T8871	50159-50169	GO:0010467	denotes	expression
T8872	50175-50179	SO:0000704	denotes	gene
T8873	50204-50210	UBERON:0004905	denotes	joints
T8874	50249-50253	SO:0000704	denotes	gene
T8875	50266-50275	UBERON:0004905	denotes	articular
T8876	50429-50435	UBERON:0004905	denotes	joints
T8877	50499-50504	UBERON:0004905	denotes	joint
T11172	53347-53357	GO:0009566	denotes	fertilized
T11102	50553-50557	PR:000000281	denotes	Gdf5
T11103	50573-50577	NCBITaxon:10088	denotes	mice
T11104	50580-50585	NCBITaxon:10088	denotes	mouse
T11105	50596-50599	SO:0000153	denotes	BAC
T11106	50655-50658	SO:0000153	denotes	BAC
T11107	50668-50672	PR:000000281	denotes	Gdf5
T11108	50685-50688	SO:0000153	denotes	BAC
T11109	50745-50752	NCBITaxon:562	denotes	E. coli
T11110	50781-50788	GO:0005634	denotes	nuclear
T11111	50821-50828	SO:0000155	denotes	plasmid
T11112	50869-50873	SO:0000243	denotes	IRES
T11113	50874-50879	PR:P05187	denotes	hPLAP
T11114	50886-50893	SO:0000155	denotes	plasmid
T11115	50943-50957	SO:0000318	denotes	ATG start site
T11116	50961-50965	PR:000000281	denotes	Gdf5
T11117	50987-50989	SO:0000028	denotes	bp
T11118	51003-51007	SO:0000147	denotes	exon
T11119	51011-51015	PR:000000281	denotes	Gdf5
T11120	51046-51050	PR:000000281	denotes	GDF5
T11121	51129-51140	SO:0000006	denotes	PCR product
T11122	51170-51187	SO:0000061	denotes	restriction sites
T11123	51206-51208	SO:0000028	denotes	bp
T11124	51215-51222	SO:0001026	denotes	genomic
T11125	51223-51227	PR:000000281	denotes	Gdf5
T11126	51251-51277	SO:0000318	denotes	ATG translation start site
T11127	51255-51272	GO:0006413	denotes	translation start
T11128	51279-51293	SO:0000121	denotes	forward primer
T11129	51334-51341	SO:0001031	denotes	reverse
T11130	51445-51449	SO:0000243	denotes	IRES
T11131	51450-51455	PR:P05187	denotes	hPLAP
T11132	51484-51495	SO:0000006	denotes	PCR product
T11133	51547-51552	PR:P05187	denotes	hPLAP
T11134	51553-51569	GO:0006415	denotes	translation stop
T11135	51553-51574	SO:0000319	denotes	translation stop site
T11136	51576-51590	SO:0000121	denotes	forward primer
T11137	51637-51644	SO:0001031	denotes	reverse
T11138	51740-51751	SO:0000006	denotes	PCR product
T11139	51781-51785	PR:000000281	denotes	Gdf5
T11140	51786-51793	SO:0001026	denotes	genomic
T11141	51814-51821	_FRAGMENT	denotes	part of
T11142	51832-51836	SO:0000852	denotes	exon
T11143	51852-51858	SO:0001014	denotes	intron
T11144	51864-51878	SO:0000121	denotes	forward primer
T11145	51912-51916	SO:0000147	denotes	exon
T11146	51953-51967	SO:0000132	denotes	reverse primer
T11147	51980-51982	NCBITaxon:10760	denotes	T7
T11148	51983-51991	SO:0000167	denotes	promoter
T11149	51999-52005	SO:0000440	denotes	vector
T11150	52041-52047	SO:0000357	denotes	flanks
T11151	52052-52060	SO:0000188	denotes	intronic
T11152	52072-52086	SO:0000121	denotes	forward primer
T11153	52126-52133	SO:0001031	denotes	reverse
T11154	52335-52341	SO:0000440	denotes	vector
T11155	52496-52499	SO:0000153	denotes	BAC
T11156	52564-52567	SO:0000153	denotes	BAC
T11157	52603-52610	NCBITaxon:33208	denotes	animals
T11158	52614-52623	SO:0000346	denotes	loxP site
T11159	52639-52649	SO:0000153	denotes	BAC vector
T11160	52738-52744	SO:0001026	denotes	genome
T11161	52758-52761	SO:0000153	denotes	BAC
T11162	52782-52786	CHEBI:63039	denotes	CsCl
T11163	52830-52836	SO:0000667	denotes	insert
T11164	52846-52852	SO:0000440	denotes	vector
T11165	52883-52890	CHEBI:17992	denotes	sucrose
T11166	52980-52986	SO:0000440	denotes	vector
T11167	53043-53049	SO:0000667	denotes	insert
T11168	53075-53081	SO:0000440	denotes	vector
T11169	53132-53136	CHEBI:9754	denotes	Tris
T11170	53276-53282	SO:0000667	denotes	insert
T11171	53333-53343	GO:0045120	denotes	pronucleus
T11173	53358-53362	CL:0000025	denotes	eggs
T11174	53374-53378	NCBITaxon:10088	denotes	mice
T11175	53435-53439	NCBITaxon:10088	denotes	mice
T11176	53482-53489	SO:0000112	denotes	primers
T11177	53581-53583	SO:0000028	denotes	bp
T11178	53626-53636	SO:0000153	denotes	BAC vector
T11179	53643-53649	SO:0000440	denotes	vector
T11180	53659-53666	SO:0000112	denotes	primers
T11181	53753-53755	SO:0000028	denotes	bp
T11182	53780-53784	PR:000000281	denotes	Gdf5
T11183	53789-53793	NCBITaxon:10088	denotes	mice
T11184	53849-53856	GO:0007618	denotes	Matings
T11185	53881-53885	PR:000033987	denotes	LACZ
T11186	53895-53899	NCBITaxon:10088	denotes	mice
T11187	53964-53968	PR:000033987	denotes	LACZ
T11188	53973-53978	PR:P05187	denotes	HPLAP
T11189	53988-53995	UBERON:0000922	denotes	embryos
T11190	54011-54018	UBERON:0000922	denotes	embryos
T11191	54096-54100	PR:000033987	denotes	LACZ
T12092	54266-54272	PR:000000035	denotes	Bmpr1a
T12093	54280-54284	NCBITaxon:10088	denotes	mice
T12094	54285-54291	PR:000000035	denotes	Bmpr1a
T12095	54301-54307	SO:0000359	denotes	floxed
T12096	54308-54315	SO:0001023	denotes	alleles
T12097	54442-54446	NCBITaxon:10088	denotes	Mice
T12098	54469-54475	SO:0000359	denotes	floxed
T12099	54476-54483	SO:0001023	denotes	alleles
T12100	54499-54504	GO:0007618	denotes	mated
T12101	54508-54512	PR:000000281	denotes	Gdf5
T12102	54517-54521	NCBITaxon:10088	denotes	mice
T12103	54558-54562	NCBITaxon:10088	denotes	mice
T12104	54640-54647	NCBITaxon:33208	denotes	animals
T12105	54687-54694	GO:0007618	denotes	matings
T12106	54708-54716	UBERON:0004288	denotes	skeletal
T12107	54761-54765	NCBITaxon:10088	denotes	mice
T12108	54797-54801	UBERON:0001690	denotes	ears
T12109	54827-54834	NCBITaxon:33208	denotes	animals
T12110	54941-54947	UBERON:0010887	denotes	tragus
T12111	54952-54962	UBERON:0016467	denotes	antitragus
T12112	55004-55010	UBERON:0001757	denotes	pinnae
T12113	55041-55045	NCBITaxon:10088	denotes	mice
T12114	55070-55077	NCBITaxon:33208	denotes	animals
T12115	55234-55239	NCBITaxon:10088	denotes	mouse
T12116	55300-55302	UBERON:0001448	denotes	MT
T12117	55303-55305	UBERON:0004302	denotes	P1
T12118	55310-55312	UBERON:0004302	denotes	P1
T12119	55313-55315	UBERON:4100005	denotes	P2
T12120	55316-55322	UBERON:0004905	denotes	joints
T12121	55330-55351	UBERON:0003632	denotes	second hindlimb digit
T12122	55378-55385	NCBITaxon:33208	denotes	animals
T12123	55417-55422	UBERON:0004905	denotes	joint
T12124	55609-55616	NCBITaxon:33208	denotes	animals
T12125	55639-55643	NCBITaxon:10088	denotes	mice
T12126	55722-55726	PR:000000281	denotes	Gdf5
T12127	55735-55741	PR:000000035	denotes	Bmpr1a
T12128	55782-55788	PR:000000035	denotes	Bmpr1a
T12129	55788-55793	SO:0000359	denotes	floxP
T12564	55938-55948	GO:0008219	denotes	Cell death
T12565	55938-55942	_FRAGMENT	denotes	Cell
T12566	55953-55966	GO:0008283	denotes	proliferation
T12567	55974-55979	UBERON:0002101	denotes	Limbs
T12568	56004-56011	NCBITaxon:33208	denotes	animals
T12569	56126-56132	UBERON:0000479	denotes	tissue
T12570	56173-56183	GO:0008219	denotes	Cell Death
T12571	56199-56210	CHEBI:31624	denotes	Fluorescein
T12572	56309-56317	CHEBI:53424	denotes	Tween-20
T12573	56323-56327	NCBITaxon:9925	denotes	goat
T12574	56328-56333	UBERON:0001977	denotes	serum
T12575	56390-56396	NCBITaxon:9986	denotes	rabbit
T12576	56402-56409	CHEBI:32958	denotes	phospho
T12577	56410-56417	CHEBI:15358	denotes	histone
T12578	56410-56420	PR:000027594	denotes	histone-H3
T12579	56421-56429	GO:0042571	denotes	antibody
T12580	56437-56444	GO:0007067	denotes	Mitosis
T12581	56535-56542	GO:0007067	denotes	mitosis
T12582	56544-56547	CHEBI:37987	denotes	Cy3
T12583	56561-56567	NCBITaxon:9986	denotes	rabbit
T12584	56578-56586	GO:0042571	denotes	antibody
T12585	56610-56618	GO:0042571	denotes	antibody
T12586	56620-56631	GO:0005634	denotes	Cell nuclei
T12587	56650-56654	CHEBI:51231	denotes	DAPI
T12588	56814-56824	UBERON:0001062	denotes	anatomical
T12589	56878-56885	GO:0005634	denotes	nuclear
T12590	56914-56917	CHEBI:37987	denotes	Cy3
T12591	56926-56932	GO:0005634	denotes	nuclei
T12592	57024-57031	NCBITaxon:33208	denotes	animals
T12593	57068-57089	_FRAGMENT	denotes	metacarpal-phalangeal
T12594	57116-57122	UBERON:0003695	denotes	joints
T12595	57094-57122	UBERON:0003696	denotes	metatarsal-phalangeal joints
T12596	57198-57203	UBERON:0004905	denotes	joint
T12597	57233-57244	UBERON:0006052	denotes	fifth digit
T12598	57284-57290	_FRAGMENT	denotes	tip of
T12599	57295-57300	UBERON:0009551	denotes	digit
T12600	57352-57358	UBERON:0000479	denotes	tissue
T12993	57448-57454	UBERON:0000479	denotes	Tissue
T12994	57460-57467	NCBITaxon:33208	denotes	animals
T12995	57661-57668	CHEBI:17992	denotes	sucrose
T12996	57700-57707	CHEBI:17992	denotes	sucrose
T12997	57779-57785	UBERON:0000479	denotes	Tissue
T12998	57791-57798	NCBITaxon:33208	denotes	animals
T12999	57944-57951	CHEBI:17992	denotes	sucrose
T13000	57957-57966	CHEBI:75958	denotes	solutions
T13001	58030-58037	UBERON:0000479	denotes	tissues
T13002	58053-58057	NCBITaxon:10088	denotes	mice
T13003	58104-58110	UBERON:0000479	denotes	Tissue
T13004	58196-58206	CHEBI:82468	denotes	Fast Green
T13005	58220-58231	CHEBI:51686	denotes	hematoxylin
T13006	58301-58305	PR:000033987	denotes	LACZ
T13007	58320-58325	CHEBI:75055	denotes	X-Gal
T13008	58435-58440	CHEBI:15377	denotes	water
T13009	58463-58470	GO:0005634	denotes	Nuclear
T13010	58508-58513	CHEBI:15377	denotes	water
T13011	58620-58633	GO:0097617	denotes	hybridization
T13012	58739-58750	MOP:0000030	denotes	acetylation
T13013	58959-58972	GO:0097617	denotes	hybridization
T13014	58999-59015	UBERON:0005291	denotes	embryonic tissue
T13015	59060-59063	CHEBI:60004	denotes	mix
T13016	59109-59114	SO:0000704	denotes	genes
T13017	59147-59153	PR:000000035	denotes	Bmpr1a
T13018	59177-59183	PR:000003266	denotes	Col2a1
T13019	59210-59217	PR:000005693	denotes	Col10a1
T13020	59238-59242	PR:000000281	denotes	Gdf5
T13021	59270-59281	PR:000030444	denotes	Osteocalcin
T13022	59309-59313	PR:000015431	denotes	Sox5
T13023	59318-59322	PR:000015432	denotes	Sox6
T13024	59389-59392	PR:000003606	denotes	Agg
T13025	59431-59435	PR:000000164	denotes	Bmp2
T13026	59440-59444	PR:000000165	denotes	Bmp4
T13027	59480-59486	PR:000003264	denotes	Col1a1
T13028	59525-59531	PR:000000036	denotes	Bmpr1b
T13029	59533-59539	PR:000003328	denotes	Col3a1
T13030	59545-59549	PR:000010208	denotes	Mat4
T13031	59572-59576	SO:0000345	denotes	ESTs
T13032	59795-59801	NCBITaxon:27592	denotes	bovine
T13033	59976-59993	CHEBI:16240	denotes	hydrogen peroxide
T13034	60002-60010	CHEBI:17790	denotes	methanol
T13035	60056-60063	CHEBI:53424	denotes	Tween20
T13036	60069-60073	NCBITaxon:9925	denotes	goat
T13037	60083-60089	NCBITaxon:27592	denotes	bovine
T13038	60090-60095	UBERON:0001977	denotes	serum
T13039	60138-60148	GO:0042571	denotes	antibodies
T13040	60164-60172	CHEBI:53424	denotes	Tween 20
T13041	60178-60182	NCBITaxon:9925	denotes	goat
T13042	60192-60198	NCBITaxon:27592	denotes	bovine
T13043	60199-60204	UBERON:0001977	denotes	serum
T13044	60224-60230	CHEBI:15956	denotes	Biotin
T13045	60249-60259	GO:0042571	denotes	antibodies
T13046	60398-60408	GO:0042571	denotes	antibodies
T13047	60434-60438	NCBITaxon:9925	denotes	goat
T13048	60444-60449	NCBITaxon:10088	denotes	mouse
T13049	60450-60455	PR:000010473	denotes	MMP13
T13050	60526-60532	NCBITaxon:9986	denotes	rabbit
T13051	60538-60543	NCBITaxon:9606	denotes	human
T13052	60544-60548	PR:000015435	denotes	SOX9
T13053	60587-60593	NCBITaxon:9986	denotes	rabbit
T13054	60614-60618	PR:000015435	denotes	SOX9
T13055	60620-60624	PR:000015435	denotes	SOX9
T5060	22510-22515	UBERON:0004905	denotes	Joint
T5061	22529-22542	UBERON:0004454	denotes	Ankle Regions
T5062	22547-22553	PR:000000035	denotes	Bmpr1a
T5063	22554-22558	SO:0000704	denotes	gene
T5064	22562-22571	GO:0010467	denotes	expressed
T5065	22610-22616	UBERON:0004905	denotes	joints
T5066	22654-22667	GO:0097617	denotes	hybridization
T5067	22684-22688	SO:0000704	denotes	gene
T5068	22697-22706	GO:0010467	denotes	expressed
T5069	22728-22740	UBERON:0001488	denotes	ankle joints
T5070	22757-22776	UBERON:0010996	denotes	articular cartilage
T5071	22788-22793	UBERON:0002544	denotes	digit
T8813	47212-47216	PR:000000034	denotes	BMPs
T8814	47324-47343	UBERON:0010996	denotes	articular cartilage
T8815	47365-47384	GO:0051216	denotes	cartilage formation
T8816	47436-47446	GO:0031099	denotes	regenerate
T8817	47468-47473	UBERON:0007023	denotes	adult
T8818	47474-47481	NCBITaxon:33208	denotes	animals
T8819	47611-47630	UBERON:0010996	denotes	articular cartilage
T8820	47656-47662	PR:000000035	denotes	BMPR1A
T8821	47703-47711	CHEBI:36357	denotes	molecule
T8822	47860-47879	UBERON:0010996	denotes	articular cartilage
T8823	47887-47892	GO:0007567	denotes	natal
T8824	47909-47915	PR:000000035	denotes	Bmpr1a
T8825	47928-47947	UBERON:0010996	denotes	articular cartilage
T8826	47986-47995	UBERON:0004905	denotes	articular
T8827	48016-48021	UBERON:0004905	denotes	joint
T8828	48080-48086	PR:000000035	denotes	Bmpr1a
T8829	48097-48101	NCBITaxon:10088	denotes	mice
T8830	48141-48144	PR:000000034	denotes	BMP
T8831	48141-48154	GO:0030509	denotes	BMP signaling
T8832	48174-48179	NCBITaxon:9606	denotes	human
T8833	48180-48185	UBERON:0004905	denotes	joint
T8834	48241-48248	SO:0000704	denotes	genetic
T8835	48292-48299	SO:0000704	denotes	genetic
T8836	48408-48414	NCBITaxon:9606	denotes	Humans
T8837	48471-48477	PR:000000035	denotes	BMPR1A
T8838	48604-48610	NCBITaxon:9606	denotes	people
R2403	T3838	T3837	_lexicallyChainedTo	of,generation
R2404	T3839	T3838	_lexicallyChainedTo	cartilage,of
R2405	T3842	T3841	_lexicallyChainedTo	limb,joints of
R2928	T4550	T4549	_lexicallyChainedTo	digits of,first
R2929	T4550	T4552	_lexicallyChainedTo	digits of,second
R2930	T4551	T4550	_lexicallyChainedTo	forelimbs,digits of
R2931	T4553	T4550	_lexicallyChainedTo	forelimbs,digits of
R2932	T4564	T4563	_lexicallyChainedTo	first and second,interdigital region between
R2933	T4565	T4564	_lexicallyChainedTo	digits,first and second
R2934	T4570	T4569	_lexicallyChainedTo	first and second digits,interdigital mesenchyme between
R2935	T4580	T4579	_lexicallyChainedTo	digits,webbed region between
R2936	T4582	T4581	_lexicallyChainedTo	digits,first
R3543	T5557	T5556	_lexicallyChainedTo	joints,metacarpal-phalangeal
R3544	T5586	T5585	_lexicallyChainedTo	proliferation,cellular
R3545	T5607	T5606	_lexicallyChainedTo	of,formation
R3546	T5608	T5607	_lexicallyChainedTo	cartilage,of
R4696	T7334	T7333	_lexicallyChainedTo	hindlimb,joint of
R4697	T7371	T7370	_lexicallyChainedTo	tibia,epiphysis of
R4698	T7375	T7374	_lexicallyChainedTo	femur,epiphysis of
R5511	T8618	T8617	_lexicallyChainedTo	development,limb
R5512	T8634	T8633	_lexicallyChainedTo	limb,development of
R5513	T8647	T8646	_lexicallyChainedTo	ankle,bones in
R5514	T8694	T8693	_lexicallyChainedTo	mRNA,decay of
R5515	T8695	T8693	_lexicallyChainedTo	protein,decay of
R5516	T8734	T8733	_lexicallyChainedTo	proteoglycans,synthesis of
R5517	T8800	T8799	_lexicallyChainedTo	signaling,TGFβ
R5518	T8809	T8808	_lexicallyChainedTo	signaling,TGFβ
R5519	T8870	T8869	_lexicallyChainedTo	gene,floxed
R7262	T11142	T11141	_lexicallyChainedTo	exon,part of
R7263	T11143	T11141	_lexicallyChainedTo	intron,part of
R8315	T12599	T12598	_lexicallyChainedTo	digit,tip of
R8313	T12566	T12565	_lexicallyChainedTo	proliferation,Cell
R8314	T12594	T12593	_lexicallyChainedTo	joints,metacarpal-phalangeal
R1	T90	T89	_lexicallyChainedTo	genes,floxed
R2	T128	T127	_lexicallyChainedTo	of,development
R3	T129	T128	_lexicallyChainedTo	tissues,of
R4	T129	T130	_lexicallyChainedTo	tissues,creation of
R354	T807	T806	_lexicallyChainedTo	mesenchymal cells,condensing
R355	T869	T868	_lexicallyChainedTo	BMP signaling pathway,modulation of
R1413	T2329	T2328	_lexicallyChainedTo	formation,embryonic
R1414	T2397	T2396	_lexicallyChainedTo	limbs,joints of
R1415	T2444	T2443	_lexicallyChainedTo	brain,regions of
R1416	T2445	T2443	_lexicallyChainedTo	spinal cord,regions of
R1417	T2460	T2459	_lexicallyChainedTo	long bones,growth plate of
R1418	T2462	T2461	_lexicallyChainedTo	brain,portions of
R1419	T2463	T2461	_lexicallyChainedTo	spinal cord,portions of
R2398	T3812	T3811	_lexicallyChainedTo	digits of,webbing between
R2399	T3812	T3814	_lexicallyChainedTo	digits of,first
R2400	T3813	T3812	_lexicallyChainedTo	feet,digits of
R2401	T3815	T3812	_lexicallyChainedTo	feet,digits of
R2402	T3817	T3816	_lexicallyChainedTo	feet,second digits of

2_test

Id	Subject	Object	Predicate	Lexical cue
15492776-7752126-84887267	2853-2857	7752126	denotes	1995
15492776-7575685-84887268	2878-2882	7575685	denotes	1995
15492776-645613-84887269	3712-3716	645613	denotes	1978
15492776-11239392-84887270	4055-4059	11239392	denotes	2001
15492776-9012517-84887271	4310-4314	9012517	denotes	1996
15492776-9218508-84887272	4331-4335	9218508	denotes	1997
15492776-10199971-84887273	4357-4361	10199971	denotes	1999
15492776-12606286-84887274	4377-4381	12606286	denotes	2003
15492776-8145850-84887275	4754-4758	8145850	denotes	1994
15492776-12606286-84887276	4774-4778	12606286	denotes	2003
15492776-7657163-84887277	4923-4927	7657163	denotes	1995
15492776-8898212-84887278	4947-4951	8898212	denotes	1996
15492776-9485084-84887279	5288-5292	9485084	denotes	1998
15492776-10639490-84887280	5313-5317	10639490	denotes	2000
15492776-12364567-84887281	5336-5340	12364567	denotes	2002
15492776-12469908-84887282	5353-5357	12469908	denotes	2002
15492776-13130469-84887283	5373-5377	13130469	denotes	2003
15492776-8674122-84887284	5624-5628	8674122	denotes	1996
15492776-8065329-84887285	5852-5856	8065329	denotes	1994
15492776-8006002-84887286	5875-5879	8006002	denotes	1994
15492776-7811286-84887287	5895-5899	7811286	denotes	1994
15492776-8702914-84887288	5917-5921	8702914	denotes	1996
15492776-9417113-84887289	5938-5942	9417113	denotes	1998
15492776-7750489-84887290	6389-6393	7750489	denotes	1995
15492776-8543149-84887291	6410-6414	8543149	denotes	1995
15492776-9303535-84887292	6427-6431	9303535	denotes	1997
15492776-10631181-84887293	6445-6449	10631181	denotes	2000
15492776-9012517-84887294	6621-6625	9012517	denotes	1996
15492776-10631181-84887295	6639-6643	10631181	denotes	2000
15492776-10631182-84887296	6655-6659	10631182	denotes	2000
15492776-8543149-84887297	6818-6822	8543149	denotes	1995
15492776-7657163-84887298	6839-6843	7657163	denotes	1995
15492776-12700086-84887299	7031-7035	12700086	denotes	2003
15492776-10686599-84887300	7325-7329	10686599	denotes	2000
15492776-9916792-84887301	9472-9476	9916792	denotes	1999
15492776-645613-84887302	12321-12325	645613	denotes	1978
15492776-9012517-84887303	13717-13721	9012517	denotes	1996
15492776-7961761-84887304	13932-13936	7961761	denotes	1994
15492776-9485084-84887305	13954-13958	9485084	denotes	1998
15492776-12027540-84887306	13974-13978	12027540	denotes	2002
15492776-11857780-84887307	17313-17317	11857780	denotes	2002
15492776-11857780-84887308	17791-17795	11857780	denotes	2002
15492776-8543149-84887309	18050-18054	8543149	denotes	1995
15492776-1339316-84887310	19234-19238	1339316	denotes	1992
15492776-8270624-84887311	20841-20845	8270624	denotes	1993
15492776-9012494-84887312	20863-20867	9012494	denotes	1996
15492776-8614838-84887313	20887-20891	8614838	denotes	1996
15492776-12217322-84887314	20905-20909	12217322	denotes	2002
15492776-10631181-84887315	22639-22643	10631181	denotes	2000
15492776-11279097-84887316	28229-28233	11279097	denotes	2001
15492776-11879535-84887317	29519-29523	11879535	denotes	2002
15492776-9442116-84887318	29761-29765	9442116	denotes	1998
15492776-9171829-84887319	30884-30888	9171829	denotes	1997
15492776-9121483-84887320	30906-30910	9121483	denotes	1997
15492776-10319868-84887321	30922-30926	10319868	denotes	1999
15492776-10753864-84887322	30942-30946	10753864	denotes	2000
15492776-8662546-84887323	32532-32536	8662546	denotes	1996
15492776-8816783-84887324	32550-32554	8816783	denotes	1996
15492776-8543149-84887325	40635-40639	8543149	denotes	1995
15492776-9012494-84887326	41361-41365	9012494	denotes	1996
15492776-8614838-84887327	41385-41389	8614838	denotes	1996
15492776-9303535-84887328	41402-41406	9303535	denotes	1997
15492776-12217322-84887329	41420-41424	12217322	denotes	2002
15492776-9012517-84887330	41918-41922	9012517	denotes	1996
15492776-10080184-84887331	41936-41940	10080184	denotes	1999
15492776-10631181-84887332	41954-41958	10631181	denotes	2000
15492776-10631182-84887333	41970-41974	10631182	denotes	2000
15492776-12606286-84887334	41990-41994	12606286	denotes	2003
15492776-9171829-84887335	44954-44958	9171829	denotes	1997
15492776-9121483-84887336	44976-44980	9121483	denotes	1997
15492776-9755172-84887337	45181-45185	9755172	denotes	1998
15492776-10805756-84887338	45200-45204	10805756	denotes	2000
15492776-12729559-84887339	45463-45467	12729559	denotes	2003
15492776-9009144-84887340	45918-45922	9009144	denotes	1997
15492776-12677004-84887341	45948-45952	12677004	denotes	2003
15492776-9755172-84887342	46152-46156	9755172	denotes	1998
15492776-10805756-84887343	46171-46175	10805756	denotes	2000
15492776-11702786-84887344	46440-46444	11702786	denotes	2001
15492776-9334355-84887345	46770-46774	9334355	denotes	1997
15492776-11285272-84887346	46788-46792	11285272	denotes	2001
15492776-7961761-84887347	47496-47500	7961761	denotes	1994
15492776-9485084-84887348	47518-47522	9485084	denotes	1998
15492776-11503137-84887349	47549-47553	11503137	denotes	2001
15492776-12798347-84887350	47580-47584	12798347	denotes	2003
15492776-8616305-84887351	48361-48365	8616305	denotes	1996
15492776-9627016-84887352	48381-48385	9627016	denotes	1998
15492776-9663480-84887353	48401-48405	9663480	denotes	1998
15492776-11381269-84887354	48538-48542	11381269	denotes	2001
15492776-11536076-84887355	48556-48560	11536076	denotes	2001
15492776-12173034-84887356	49164-49168	12173034	denotes	2002
15492776-10486325-84887357	49235-49239	10486325	denotes	1999
15492776-8660106-84887358	49323-49327	8660106	denotes	1996
15492776-9306400-84887359	50766-50770	9306400	denotes	1997
15492776-9306400-84887360	52389-52393	9306400	denotes	1997
15492776-9916792-84887361	53909-53913	9916792	denotes	1999
15492776-10191045-84887362	54081-54085	10191045	denotes	1999
15492776-11714671-84887363	54328-54332	11714671	denotes	2001
15492776-11857780-84887364	54349-54353	11857780	denotes	2002
15492776-1359423-84887365	54781-54785	1359423	denotes	1992
15492776-10191045-84887366	58366-58370	10191045	denotes	1999
15492776-9012517-84887367	58681-58685	9012517	denotes	1996
15492776-11180952-84887368	59077-59081	11180952	denotes	2001
15492776-8543149-84887369	59170-59174	8543149	denotes	1995
15492776-2054384-84887370	59203-59207	2054384	denotes	1991
15492776-1587271-84887371	59231-59235	1587271	denotes	1992
15492776-9012517-84887372	59263-59267	9012517	denotes	1996
15492776-3019668-84887373	59298-59302	3019668	denotes	1986
15492776-9755172-84887374	59340-59344	9755172	denotes	1998
15492776-8782821-84887375	60580-60584	8782821	denotes	1996
15492776-10805756-84887376	60654-60658	10805756	denotes	2000
T97819	2853-2857	7752126	denotes	1995
T21026	2878-2882	7575685	denotes	1995
T29900	3712-3716	645613	denotes	1978
T45831	4055-4059	11239392	denotes	2001
T99717	4310-4314	9012517	denotes	1996
T74898	4331-4335	9218508	denotes	1997
T93044	4357-4361	10199971	denotes	1999
T38753	4377-4381	12606286	denotes	2003
T58079	4754-4758	8145850	denotes	1994
T30702	4774-4778	12606286	denotes	2003
T96774	4923-4927	7657163	denotes	1995
T87715	4947-4951	8898212	denotes	1996
T51614	5288-5292	9485084	denotes	1998
T85849	5313-5317	10639490	denotes	2000
T12837	5336-5340	12364567	denotes	2002
T9866	5353-5357	12469908	denotes	2002
T98714	5373-5377	13130469	denotes	2003
T39390	5624-5628	8674122	denotes	1996
T17765	5852-5856	8065329	denotes	1994
T87251	5875-5879	8006002	denotes	1994
T97683	5895-5899	7811286	denotes	1994
T40167	5917-5921	8702914	denotes	1996
T14183	5938-5942	9417113	denotes	1998
T15645	6389-6393	7750489	denotes	1995
T62583	6410-6414	8543149	denotes	1995
T11125	6427-6431	9303535	denotes	1997
T62638	6445-6449	10631181	denotes	2000
T67445	6621-6625	9012517	denotes	1996
T34355	6639-6643	10631181	denotes	2000
T81057	6655-6659	10631182	denotes	2000
T19725	6818-6822	8543149	denotes	1995
T44085	6839-6843	7657163	denotes	1995
T93170	7031-7035	12700086	denotes	2003
T37516	7325-7329	10686599	denotes	2000
T82443	9472-9476	9916792	denotes	1999
T26594	12321-12325	645613	denotes	1978
T79170	13717-13721	9012517	denotes	1996
T33344	13932-13936	7961761	denotes	1994
T28398	13954-13958	9485084	denotes	1998
T63410	13974-13978	12027540	denotes	2002
T80010	17313-17317	11857780	denotes	2002
T88995	17791-17795	11857780	denotes	2002
T59203	18050-18054	8543149	denotes	1995
T7576	19234-19238	1339316	denotes	1992
T80418	20841-20845	8270624	denotes	1993
T21180	20863-20867	9012494	denotes	1996
T13954	20887-20891	8614838	denotes	1996
T30694	20905-20909	12217322	denotes	2002
T67340	22639-22643	10631181	denotes	2000
T18957	28229-28233	11279097	denotes	2001
T2296	29519-29523	11879535	denotes	2002
T16450	29761-29765	9442116	denotes	1998
T18583	30884-30888	9171829	denotes	1997
T21111	30906-30910	9121483	denotes	1997
T83716	30922-30926	10319868	denotes	1999
T61024	30942-30946	10753864	denotes	2000
T52694	32532-32536	8662546	denotes	1996
T50222	32550-32554	8816783	denotes	1996
T5475	40635-40639	8543149	denotes	1995
T50671	41361-41365	9012494	denotes	1996
T90240	41385-41389	8614838	denotes	1996
T55305	41402-41406	9303535	denotes	1997
T82804	41420-41424	12217322	denotes	2002
T73528	41918-41922	9012517	denotes	1996
T28974	41936-41940	10080184	denotes	1999
T82867	41954-41958	10631181	denotes	2000
T34895	41970-41974	10631182	denotes	2000
T3226	41990-41994	12606286	denotes	2003
T75708	44954-44958	9171829	denotes	1997
T20775	44976-44980	9121483	denotes	1997
T53037	45181-45185	9755172	denotes	1998
T45112	45200-45204	10805756	denotes	2000
T46275	45463-45467	12729559	denotes	2003
T99416	45918-45922	9009144	denotes	1997
T47501	45948-45952	12677004	denotes	2003
T55074	46152-46156	9755172	denotes	1998
T34298	46171-46175	10805756	denotes	2000
T1628	46440-46444	11702786	denotes	2001
T8674	46770-46774	9334355	denotes	1997
T82916	46788-46792	11285272	denotes	2001
T44616	47496-47500	7961761	denotes	1994
T58509	47518-47522	9485084	denotes	1998
T59637	47549-47553	11503137	denotes	2001
T40935	47580-47584	12798347	denotes	2003
T93175	48361-48365	8616305	denotes	1996
T57319	48381-48385	9627016	denotes	1998
T57425	48401-48405	9663480	denotes	1998
T7680	48538-48542	11381269	denotes	2001
T1053	48556-48560	11536076	denotes	2001
T1997	49164-49168	12173034	denotes	2002
T81068	49235-49239	10486325	denotes	1999
T13309	49323-49327	8660106	denotes	1996
T78234	50766-50770	9306400	denotes	1997
T36476	52389-52393	9306400	denotes	1997
T52136	53909-53913	9916792	denotes	1999
T76039	54081-54085	10191045	denotes	1999
T51688	54328-54332	11714671	denotes	2001
T35728	54349-54353	11857780	denotes	2002
T95755	54781-54785	1359423	denotes	1992
T78920	58366-58370	10191045	denotes	1999
T5412	58681-58685	9012517	denotes	1996
T43231	59077-59081	11180952	denotes	2001
T21043	59170-59174	8543149	denotes	1995
T1204	59203-59207	2054384	denotes	1991
T78538	59231-59235	1587271	denotes	1992
T38243	59263-59267	9012517	denotes	1996
T98595	59298-59302	3019668	denotes	1986
T93062	59340-59344	9755172	denotes	1998
T9409	60580-60584	8782821	denotes	1996
T31789	60654-60658	10805756	denotes	2000

PMC:523229 JSONTXT

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PMC:523229 JSON TXT