PMC:516044 / 3241-4233 JSONTXT

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Detailed studies aimed at identifying the direct cause of deafness in Pendred syndrome have recently become possible due to the generation of a pendrin-specific polyclonal antibody [9] and the development of Slc26a4-/- mice, which bear a targeted disruption of the mouse Slc26a4 gene [14]. The aim in the present study was to determine the location of pendrin and the cause of deafness in Slc26a4-/- 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