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PMC:516044 / 129-2013 JSONTXT

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Id Subject Object Predicate Lexical cue
T253 0-10 NN denotes Background
T254 10-175 sentence denotes Pendred syndrome, a common autosomal-recessive disorder characterized by congenital deafness and goiter, is caused by mutations of SLC26A4, which codes for pendrin.
T255 11-18 NNP denotes Pendred
T256 19-27 NN denotes syndrome
T257 119-125 VBN denotes caused
T258 27-29 , denotes ,
T259 29-30 DT denotes a
T260 58-66 NN denotes disorder
T261 31-37 JJ denotes common
T262 38-47 JJ denotes autosomal
T263 48-57 JJ denotes recessive
T264 47-48 HYPH denotes -
T265 67-80 VBN denotes characterized
T266 81-83 IN denotes by
T267 84-94 JJ denotes congenital
T268 95-103 NN denotes deafness
T269 104-107 CC denotes and
T270 108-114 NN denotes goiter
T271 114-116 , denotes ,
T272 116-118 VBZ denotes is
T273 126-128 IN denotes by
T274 129-138 NNS denotes mutations
T275 139-141 IN denotes of
T276 142-149 NN denotes SLC26A4
T277 149-151 , denotes ,
T278 151-156 WDT denotes which
T279 157-162 VBZ denotes codes
T280 163-166 IN denotes for
T281 167-174 NN denotes pendrin
T282 174-175 . denotes .
T283 175-317 sentence denotes We investigated the relationship between pendrin and deafness using mice that have (Slc26a4+/+) or lack a complete Slc26a4 gene (Slc26a4-/-).
T284 176-178 PRP denotes We
T285 179-191 VBD denotes investigated
T286 192-195 DT denotes the
T287 196-208 NN denotes relationship
T288 209-216 IN denotes between
T289 217-224 NN denotes pendrin
T290 225-228 CC denotes and
T291 229-237 NN denotes deafness
T292 238-243 VBG denotes using
T293 244-248 NNS denotes mice
T294 249-253 WDT denotes that
T295 254-258 VBP denotes have
T296 259-260 -LRB- denotes (
T297 260-267 NN denotes Slc26a4
T298 267-268 SYM denotes +
T299 268-269 HYPH denotes /
T300 269-270 SYM denotes +
T301 270-271 -RRB- denotes )
T302 272-274 CC denotes or
T303 275-279 VBP denotes lack
T304 280-281 DT denotes a
T305 299-303 NN denotes gene
T306 282-290 JJ denotes complete
T307 291-298 NN denotes Slc26a4
T308 304-305 -LRB- denotes (
T309 314-315 SYM denotes -
T310 305-312 NN denotes Slc26a4
T311 312-313 SYM denotes -
T312 313-314 HYPH denotes /
T313 315-316 -RRB- denotes )
T314 316-317 . denotes .
T315 317-326 sentence denotes Methods
T316 319-326 NNS denotes Methods
T317 326-415 sentence denotes Expression of pendrin and other proteins was determined by confocal immunocytochemistry.
T318 327-337 NN denotes Expression
T319 372-382 VBN denotes determined
T320 338-340 IN denotes of
T321 341-348 NN denotes pendrin
T322 349-352 CC denotes and
T323 353-358 JJ denotes other
T324 359-367 NN denotes proteins
T325 368-371 VBD denotes was
T326 383-385 IN denotes by
T327 386-394 JJ denotes confocal
T328 395-414 NN denotes immunocytochemistry
T329 414-415 . denotes .
T330 415-473 sentence denotes Expression of mRNA was determined by quantitative RT-PCR.
T331 416-426 NN denotes Expression
T332 439-449 VBN denotes determined
T333 427-429 IN denotes of
T334 430-434 NN denotes mRNA
T335 435-438 VBD denotes was
T336 450-452 IN denotes by
T337 453-465 JJ denotes quantitative
T338 469-472 NN denotes PCR
T339 466-468 NN denotes RT
T340 468-469 HYPH denotes -
T341 472-473 . denotes .
T342 473-591 sentence denotes The endocochlear potential and the endolymphatic K+ concentration were measured with double-barreled microelectrodes.
T343 474-477 DT denotes The
T344 491-500 NN denotes potential
T345 478-490 JJ denotes endocochlear
T346 545-553 VBN denotes measured
T347 501-504 CC denotes and
T348 505-508 DT denotes the
T349 526-539 NN denotes concentration
T350 509-522 JJ denotes endolymphatic
T351 523-524 NN denotes K
T352 524-525 SYM denotes +
T353 540-544 VBD denotes were
T354 554-558 IN denotes with
T355 559-565 JJ denotes double
T356 566-574 JJ denotes barreled
T357 565-566 HYPH denotes -
T358 575-590 NNS denotes microelectrodes
T359 590-591 . denotes .
T360 591-676 sentence denotes Currents generated by the stria marginal cells were recorded with a vibrating probe.
T361 592-600 NNS denotes Currents
T362 644-652 VBN denotes recorded
T363 601-610 VBN denotes generated
T364 611-613 IN denotes by
T365 614-617 DT denotes the
T366 633-638 NNS denotes cells
T367 618-623 NN denotes stria
T368 624-632 JJ denotes marginal
T369 639-643 VBD denotes were
T370 653-657 IN denotes with
T371 658-659 DT denotes a
T372 670-675 NN denotes probe
T373 660-669 VBG denotes vibrating
T374 675-676 . denotes .
T375 676-792 sentence denotes Tissue masses were evaluated by morphometric distance measurements and pigmentation was quantified by densitometry.
T376 677-683 NN denotes Tissue
T377 684-690 NNS denotes masses
T378 696-705 VBN denotes evaluated
T379 691-695 VBD denotes were
T380 706-708 IN denotes by
T381 709-721 JJ denotes morphometric
T382 731-743 NNS denotes measurements
T383 722-730 NN denotes distance
T384 744-747 CC denotes and
T385 748-760 NN denotes pigmentation
T386 765-775 VBN denotes quantified
T387 761-764 VBD denotes was
T388 776-778 IN denotes by
T389 779-791 NN denotes densitometry
T390 791-792 . denotes .
T391 792-801 sentence denotes Results
T392 794-801 NNS denotes Results
T393 801-959 sentence denotes Pendrin was found in the cochlea in apical membranes of spiral prominence cells and spindle-shaped cells of stria vascularis, in outer sulcus and root cells.
T394 802-809 NN denotes Pendrin
T395 814-819 VBN denotes found
T396 810-813 VBD denotes was
T397 820-822 IN denotes in
T398 823-826 DT denotes the
T399 827-834 NN denotes cochlea
T400 835-837 IN denotes in
T401 838-844 JJ denotes apical
T402 845-854 NNS denotes membranes
T403 855-857 IN denotes of
T404 858-864 JJ denotes spiral
T405 876-881 NNS denotes cells
T406 865-875 NN denotes prominence
T407 882-885 CC denotes and
T408 886-893 NN denotes spindle
T409 894-900 VBN denotes shaped
T410 893-894 HYPH denotes -
T411 901-906 NNS denotes cells
T412 907-909 IN denotes of
T413 910-915 NN denotes stria
T414 916-926 NN denotes vascularis
T415 926-928 , denotes ,
T416 928-930 IN denotes in
T417 931-936 JJ denotes outer
T418 953-958 NNS denotes cells
T419 937-943 NN denotes sulcus
T420 944-947 CC denotes and
T421 948-952 NN denotes root
T422 958-959 . denotes .
T423 959-1096 sentence denotes Endolymph volume in Slc26a4-/- mice was increased and tissue masses in areas normally occupied by type I and II fibrocytes were reduced.
T424 960-969 NN denotes Endolymph
T425 970-976 NN denotes volume
T426 1000-1009 VBN denotes increased
T427 977-979 IN denotes in
T428 980-987 NN denotes Slc26a4
T429 991-995 NNS denotes mice
T430 987-988 SYM denotes -
T431 988-989 HYPH denotes /
T432 989-990 SYM denotes -
T433 996-999 VBD denotes was
T434 1010-1013 CC denotes and
T435 1014-1020 NN denotes tissue
T436 1021-1027 NNS denotes masses
T437 1088-1095 VBN denotes reduced
T438 1028-1030 IN denotes in
T439 1031-1036 NNS denotes areas
T440 1037-1045 RB denotes normally
T441 1046-1054 VBN denotes occupied
T442 1055-1057 IN denotes by
T443 1058-1062 NN denotes type
T444 1063-1064 CD denotes I
T445 1072-1082 NNS denotes fibrocytes
T446 1065-1068 CC denotes and
T447 1069-1071 CD denotes II
T448 1083-1087 VBD denotes were
T449 1095-1096 . denotes .
T450 1096-1254 sentence denotes Slc26a4-/- mice lacked the endocochlear potential, which is generated across the basal cell barrier by the K+ channel KCNJ10 localized in intermediate cells.
T451 1097-1104 NN denotes Slc26a4
T452 1108-1112 NNS denotes mice
T453 1104-1105 SYM denotes -
T454 1105-1106 HYPH denotes /
T455 1106-1107 SYM denotes -
T456 1113-1119 VBD denotes lacked
T457 1120-1123 DT denotes the
T458 1137-1146 NN denotes potential
T459 1124-1136 JJ denotes endocochlear
T460 1146-1148 , denotes ,
T461 1148-1153 WDT denotes which
T462 1157-1166 VBN denotes generated
T463 1154-1156 VBZ denotes is
T464 1167-1173 IN denotes across
T465 1174-1177 DT denotes the
T466 1189-1196 NN denotes barrier
T467 1178-1183 JJ denotes basal
T468 1184-1188 NN denotes cell
T469 1197-1199 IN denotes by
T470 1200-1203 DT denotes the
T471 1207-1214 NN denotes channel
T472 1204-1205 NN denotes K
T473 1205-1206 SYM denotes +
T474 1215-1221 NN denotes KCNJ10
T475 1222-1231 VBN denotes localized
T476 1232-1234 IN denotes in
T477 1235-1247 JJ denotes intermediate
T478 1248-1253 NNS denotes cells
T479 1253-1254 . denotes .
T480 1254-1336 sentence denotes Stria vascularis was hyperpigmented, suggesting unalleviated free radical damage.
T481 1255-1260 NN denotes Stria
T482 1261-1271 NN denotes vascularis
T483 1272-1275 VBD denotes was
T484 1276-1290 JJ denotes hyperpigmented
T485 1290-1292 , denotes ,
T486 1292-1302 VBG denotes suggesting
T487 1303-1315 JJ denotes unalleviated
T488 1329-1335 NN denotes damage
T489 1316-1320 JJ denotes free
T490 1321-1328 NN denotes radical
T491 1335-1336 . denotes .
T492 1336-1455 sentence denotes The basal cell barrier appeared intact; intermediate cells and KCNJ10 mRNA were present but KCNJ10 protein was absent.
T493 1337-1340 DT denotes The
T494 1352-1359 NN denotes barrier
T495 1341-1346 JJ denotes basal
T496 1347-1351 NN denotes cell
T497 1360-1368 VBD denotes appeared
T498 1412-1416 VBD denotes were
T499 1369-1375 JJ denotes intact
T500 1375-1376 : denotes ;
T501 1377-1389 JJ denotes intermediate
T502 1390-1395 NNS denotes cells
T503 1396-1399 CC denotes and
T504 1400-1406 NN denotes KCNJ10
T505 1407-1411 NN denotes mRNA
T506 1417-1424 JJ denotes present
T507 1425-1428 CC denotes but
T508 1429-1435 NN denotes KCNJ10
T509 1436-1443 NN denotes protein
T510 1444-1447 VBD denotes was
T511 1448-1454 JJ denotes absent
T512 1454-1455 . denotes .
T513 1455-1665 sentence denotes Endolymphatic K+ concentrations were normal and membrane proteins necessary for K+ secretion were present, including the K+ channel KCNQ1 and KCNE1, Na+/2Cl-/K+ cotransporter SLC12A2 and the gap junction GJB2.
T514 1456-1469 JJ denotes Endolymphatic
T515 1473-1487 NNS denotes concentrations
T516 1470-1471 NN denotes K
T517 1471-1472 SYM denotes +
T518 1488-1492 VBD denotes were
T519 1493-1499 JJ denotes normal
T520 1500-1503 CC denotes and
T521 1504-1512 NN denotes membrane
T522 1513-1521 NN denotes proteins
T523 1549-1553 VBD denotes were
T524 1522-1531 JJ denotes necessary
T525 1532-1535 IN denotes for
T526 1536-1537 NN denotes K
T527 1539-1548 NN denotes secretion
T528 1537-1538 SYM denotes +
T529 1554-1561 JJ denotes present
T530 1561-1563 , denotes ,
T531 1563-1572 VBG denotes including
T532 1573-1576 DT denotes the
T533 1580-1587 NN denotes channel
T534 1577-1578 NN denotes K
T535 1578-1579 SYM denotes +
T536 1588-1593 NN denotes KCNQ1
T537 1594-1597 CC denotes and
T538 1598-1603 NN denotes KCNE1
T539 1603-1605 , denotes ,
T540 1605-1607 NN denotes Na
T541 1617-1630 NN denotes cotransporter
T542 1607-1608 SYM denotes +
T543 1608-1609 HYPH denotes /
T544 1609-1612 NN denotes 2Cl
T545 1612-1613 SYM denotes -
T546 1613-1614 HYPH denotes /
T547 1614-1615 NN denotes K
T548 1615-1616 SYM denotes +
T549 1631-1638 NN denotes SLC12A2
T550 1639-1642 CC denotes and
T551 1643-1646 DT denotes the
T552 1651-1659 NN denotes junction
T553 1647-1650 NN denotes gap
T554 1660-1664 NN denotes GJB2
T555 1664-1665 . denotes .
T556 1665-1678 sentence denotes Conclusions
T557 1667-1678 NNS denotes Conclusions
T558 1678-1884 sentence denotes These observations demonstrate that pendrin dysfunction leads to a loss of KCNJ10 protein expression and a loss of the endocochlear potential, which may be the direct cause of deafness in Pendred syndrome.
T559 1679-1684 DT denotes These
T560 1685-1697 NNS denotes observations
T561 1698-1709 VBP denotes demonstrate
T562 1710-1714 IN denotes that
T563 1735-1740 VBZ denotes leads
T564 1715-1722 NN denotes pendrin
T565 1723-1734 NN denotes dysfunction
T566 1741-1743 IN denotes to
T567 1744-1745 DT denotes a
T568 1746-1750 NN denotes loss
T569 1751-1753 IN denotes of
T570 1754-1760 NN denotes KCNJ10
T571 1769-1779 NN denotes expression
T572 1761-1768 NN denotes protein
T573 1780-1783 CC denotes and
T574 1784-1785 DT denotes a
T575 1786-1790 NN denotes loss
T576 1791-1793 IN denotes of
T577 1794-1797 DT denotes the
T578 1811-1820 NN denotes potential
T579 1798-1810 JJ denotes endocochlear
T580 1820-1822 , denotes ,
T581 1822-1827 WDT denotes which
T582 1832-1834 VB denotes be
T583 1828-1831 MD denotes may
T584 1835-1838 DT denotes the
T585 1846-1851 NN denotes cause
T586 1839-1845 JJ denotes direct
T587 1852-1854 IN denotes of
T588 1855-1863 NN denotes deafness
T589 1864-1866 IN denotes in
T590 1867-1874 NNP denotes Pendred
T591 1875-1883 NN denotes syndrome
T592 1883-1884 . denotes .
T1314 474-477 DT denotes The
T1315 491-500 NN denotes potential
T1316 478-490 JJ denotes endocochlear
T1318 501-504 CC denotes and
T1319 505-508 DT denotes the
T1321 509-522 JJ denotes endolymphatic
T252 0-10 sentence denotes Background
R36 T270 T268 conj goiter,deafness
R35 T269 T268 cc and,deafness
R22 T255 T256 compound Pendred,syndrome
R23 T256 T257 nsubjpass syndrome,caused
R24 T258 T256 punct ", ",syndrome
R25 T259 T260 det a,disorder
R26 T260 T256 appos disorder,syndrome
R27 T261 T260 amod common,disorder
R28 T262 T263 amod autosomal,recessive
R29 T263 T260 amod recessive,disorder
R30 T264 T263 punct -,recessive
R31 T265 T260 acl characterized,disorder
R32 T266 T265 agent by,characterized
R33 T267 T268 amod congenital,deafness
R34 T268 T266 pobj deafness,by
R37 T271 T257 punct ", ",caused
R38 T272 T257 auxpass is,caused
R39 T273 T257 agent by,caused
R40 T274 T273 pobj mutations,by
R41 T275 T274 prep of,mutations
R42 T276 T275 pobj SLC26A4,of
R43 T277 T276 punct ", ",SLC26A4
R44 T278 T279 dep which,codes
R45 T279 T276 relcl codes,SLC26A4
R46 T280 T279 prep for,codes
R47 T281 T280 pobj pendrin,for
R48 T282 T257 punct .,caused
R49 T284 T285 nsubj We,investigated
R50 T286 T287 det the,relationship
R51 T287 T285 dobj relationship,investigated
R52 T288 T287 prep between,relationship
R53 T289 T288 pobj pendrin,between
R54 T290 T289 cc and,pendrin
R55 T291 T289 conj deafness,pendrin
R56 T292 T285 advcl using,investigated
R57 T293 T292 dobj mice,using
R58 T294 T295 dep that,have
R59 T295 T293 relcl have,mice
R60 T296 T297 punct (,Slc26a4
R61 T297 T295 parataxis Slc26a4,have
R62 T298 T297 punct +,Slc26a4
R63 T299 T297 punct /,Slc26a4
R64 T300 T297 punct +,Slc26a4
R65 T301 T297 punct ),Slc26a4
R66 T302 T295 cc or,have
R67 T303 T295 conj lack,have
R68 T304 T305 det a,gene
R69 T305 T303 dobj gene,lack
R70 T306 T305 amod complete,gene
R71 T307 T305 compound Slc26a4,gene
R72 T308 T309 punct (,-
R73 T309 T303 punct -,lack
R74 T310 T309 nmod Slc26a4,-
R75 T311 T309 punct -,-
R76 T312 T309 punct /,-
R77 T313 T309 punct ),-
R78 T314 T285 punct .,investigated
R79 T318 T319 nsubjpass Expression,determined
R80 T320 T318 prep of,Expression
R81 T321 T320 pobj pendrin,of
R82 T322 T321 cc and,pendrin
R83 T323 T324 amod other,proteins
R84 T324 T321 conj proteins,pendrin
R85 T325 T319 auxpass was,determined
R86 T326 T319 prep by,determined
R87 T327 T328 amod confocal,immunocytochemistry
R88 T328 T326 pobj immunocytochemistry,by
R89 T329 T319 punct .,determined
R90 T331 T332 nsubjpass Expression,determined
R91 T333 T331 prep of,Expression
R92 T334 T333 pobj mRNA,of
R93 T335 T332 auxpass was,determined
R94 T336 T332 prep by,determined
R95 T337 T338 amod quantitative,PCR
R96 T338 T336 pobj PCR,by
R97 T339 T338 compound RT,PCR
R98 T340 T338 punct -,PCR
R99 T341 T332 punct .,determined
R100 T343 T344 det The,potential
R101 T344 T346 nsubjpass potential,measured
R102 T345 T344 amod endocochlear,potential
R103 T347 T344 cc and,potential
R104 T348 T349 det the,concentration
R105 T349 T344 conj concentration,potential
R106 T350 T349 amod endolymphatic,concentration
R107 T351 T349 nmod K,concentration
R108 T352 T351 punct +,K
R109 T353 T346 auxpass were,measured
R110 T354 T346 prep with,measured
R111 T355 T356 amod double,barreled
R112 T356 T358 amod barreled,microelectrodes
R113 T357 T356 punct -,barreled
R114 T358 T354 pobj microelectrodes,with
R115 T359 T346 punct .,measured
R116 T361 T362 nsubjpass Currents,recorded
R117 T363 T361 acl generated,Currents
R118 T364 T363 agent by,generated
R119 T365 T366 det the,cells
R120 T366 T364 pobj cells,by
R121 T367 T366 nmod stria,cells
R122 T368 T366 amod marginal,cells
R123 T369 T362 auxpass were,recorded
R124 T370 T362 prep with,recorded
R125 T371 T372 det a,probe
R126 T372 T370 pobj probe,with
R127 T373 T372 amod vibrating,probe
R128 T374 T362 punct .,recorded
R129 T376 T377 compound Tissue,masses
R130 T377 T378 nsubjpass masses,evaluated
R131 T379 T378 auxpass were,evaluated
R132 T380 T378 prep by,evaluated
R133 T381 T382 amod morphometric,measurements
R134 T382 T380 pobj measurements,by
R135 T383 T382 compound distance,measurements
R136 T384 T378 cc and,evaluated
R137 T385 T386 nsubjpass pigmentation,quantified
R138 T386 T378 conj quantified,evaluated
R139 T387 T386 auxpass was,quantified
R140 T388 T386 prep by,quantified
R141 T389 T388 pobj densitometry,by
R142 T390 T386 punct .,quantified
R143 T394 T395 nsubjpass Pendrin,found
R144 T396 T395 auxpass was,found
R145 T397 T395 prep in,found
R146 T398 T399 det the,cochlea
R147 T399 T397 pobj cochlea,in
R148 T400 T395 prep in,found
R149 T401 T402 amod apical,membranes
R150 T402 T400 pobj membranes,in
R151 T403 T402 prep of,membranes
R152 T404 T405 amod spiral,cells
R153 T405 T403 pobj cells,of
R154 T406 T405 compound prominence,cells
R155 T407 T402 cc and,membranes
R156 T408 T409 npadvmod spindle,shaped
R157 T409 T411 amod shaped,cells
R158 T410 T409 punct -,shaped
R159 T411 T402 conj cells,membranes
R160 T412 T411 prep of,cells
R161 T413 T414 compound stria,vascularis
R162 T414 T412 pobj vascularis,of
R163 T415 T395 punct ", ",found
R164 T416 T395 prep in,found
R165 T417 T418 amod outer,cells
R166 T418 T416 pobj cells,in
R167 T419 T418 nmod sulcus,cells
R168 T420 T419 cc and,sulcus
R169 T421 T419 conj root,sulcus
R170 T422 T395 punct .,found
R171 T424 T425 compound Endolymph,volume
R172 T425 T426 nsubjpass volume,increased
R173 T427 T425 prep in,volume
R174 T428 T429 nmod Slc26a4,mice
R175 T429 T427 pobj mice,in
R176 T430 T428 punct -,Slc26a4
R177 T431 T428 punct /,Slc26a4
R178 T432 T428 punct -,Slc26a4
R179 T433 T426 auxpass was,increased
R180 T434 T426 cc and,increased
R181 T435 T436 compound tissue,masses
R182 T436 T437 nsubjpass masses,reduced
R183 T437 T426 conj reduced,increased
R184 T438 T436 prep in,masses
R185 T439 T438 pobj areas,in
R186 T440 T441 advmod normally,occupied
R187 T441 T439 acl occupied,areas
R188 T442 T441 agent by,occupied
R189 T443 T444 nmod type,I
R190 T444 T445 nummod I,fibrocytes
R191 T445 T442 pobj fibrocytes,by
R192 T446 T444 cc and,I
R193 T447 T444 conj II,I
R194 T448 T437 auxpass were,reduced
R195 T449 T437 punct .,reduced
R196 T451 T452 nmod Slc26a4,mice
R197 T452 T456 nsubj mice,lacked
R198 T453 T451 punct -,Slc26a4
R199 T454 T451 punct /,Slc26a4
R200 T455 T451 punct -,Slc26a4
R201 T457 T458 det the,potential
R202 T458 T456 dobj potential,lacked
R203 T459 T458 amod endocochlear,potential
R204 T460 T458 punct ", ",potential
R205 T461 T462 dep which,generated
R206 T462 T458 relcl generated,potential
R207 T463 T462 auxpass is,generated
R208 T464 T462 prep across,generated
R209 T465 T466 det the,barrier
R210 T466 T464 pobj barrier,across
R211 T467 T466 amod basal,barrier
R212 T468 T466 compound cell,barrier
R213 T469 T462 agent by,generated
R214 T470 T471 det the,channel
R215 T471 T469 pobj channel,by
R216 T472 T471 nmod K,channel
R217 T473 T472 punct +,K
R218 T474 T471 appos KCNJ10,channel
R219 T475 T471 acl localized,channel
R220 T476 T475 prep in,localized
R221 T477 T478 amod intermediate,cells
R222 T478 T476 pobj cells,in
R223 T479 T456 punct .,lacked
R224 T481 T482 compound Stria,vascularis
R225 T482 T483 nsubj vascularis,was
R226 T484 T483 acomp hyperpigmented,was
R227 T485 T483 punct ", ",was
R228 T486 T483 advcl suggesting,was
R229 T487 T488 amod unalleviated,damage
R230 T488 T486 dobj damage,suggesting
R231 T489 T490 amod free,radical
R232 T490 T488 compound radical,damage
R233 T491 T483 punct .,was
R234 T493 T494 det The,barrier
R235 T494 T497 nsubj barrier,appeared
R236 T495 T494 amod basal,barrier
R237 T496 T494 compound cell,barrier
R238 T497 T498 ccomp appeared,were
R239 T499 T497 oprd intact,appeared
R240 T500 T498 punct ;,were
R241 T501 T502 amod intermediate,cells
R242 T502 T498 nsubj cells,were
R243 T503 T502 cc and,cells
R244 T504 T505 compound KCNJ10,mRNA
R245 T505 T502 conj mRNA,cells
R246 T506 T498 acomp present,were
R247 T507 T498 cc but,were
R248 T508 T509 compound KCNJ10,protein
R249 T509 T510 nsubj protein,was
R250 T510 T498 conj was,were
R251 T511 T510 acomp absent,was
R252 T512 T498 punct .,were
R253 T514 T515 amod Endolymphatic,concentrations
R254 T515 T518 nsubj concentrations,were
R255 T516 T515 nmod K,concentrations
R256 T517 T516 punct +,K
R257 T519 T518 acomp normal,were
R258 T520 T518 cc and,were
R259 T521 T522 compound membrane,proteins
R260 T522 T523 nsubj proteins,were
R261 T523 T518 conj were,were
R262 T524 T522 amod necessary,proteins
R263 T525 T524 prep for,necessary
R264 T526 T527 nmod K,secretion
R265 T527 T525 pobj secretion,for
R266 T528 T526 punct +,K
R267 T529 T523 acomp present,were
R268 T530 T523 punct ", ",were
R269 T531 T523 prep including,were
R270 T532 T533 det the,channel
R271 T533 T531 pobj channel,including
R272 T534 T533 nmod K,channel
R273 T535 T534 punct +,K
R274 T536 T533 appos KCNQ1,channel
R275 T537 T536 cc and,KCNQ1
R276 T538 T536 conj KCNE1,KCNQ1
R277 T539 T533 punct ", ",channel
R278 T540 T541 nmod Na,cotransporter
R279 T541 T549 compound cotransporter,SLC12A2
R280 T542 T540 punct +,Na
R281 T543 T540 punct /,Na
R282 T544 T540 appos 2Cl,Na
R283 T545 T544 punct -,2Cl
R284 T546 T540 punct /,Na
R285 T547 T540 appos K,Na
R286 T548 T547 punct +,K
R287 T549 T533 conj SLC12A2,channel
R288 T550 T549 cc and,SLC12A2
R289 T551 T552 det the,junction
R290 T552 T549 conj junction,SLC12A2
R291 T553 T552 compound gap,junction
R292 T554 T552 appos GJB2,junction
R293 T555 T523 punct .,were
R294 T559 T560 det These,observations
R295 T560 T561 nsubj observations,demonstrate
R296 T562 T563 mark that,leads
R297 T563 T561 ccomp leads,demonstrate
R298 T564 T565 compound pendrin,dysfunction
R299 T565 T563 nsubj dysfunction,leads
R300 T566 T563 prep to,leads
R301 T567 T568 det a,loss
R302 T568 T566 pobj loss,to
R303 T569 T568 prep of,loss
R304 T570 T571 compound KCNJ10,expression
R305 T571 T569 pobj expression,of
R306 T572 T571 compound protein,expression
R307 T573 T568 cc and,loss
R308 T574 T575 det a,loss
R309 T575 T568 conj loss,loss
R310 T576 T575 prep of,loss
R311 T577 T578 det the,potential
R312 T578 T576 pobj potential,of
R313 T579 T578 amod endocochlear,potential
R314 T580 T575 punct ", ",loss
R315 T581 T582 dep which,be
R316 T582 T575 relcl be,loss
R317 T583 T582 aux may,be
R318 T584 T585 det the,cause
R319 T585 T582 attr cause,be
R320 T586 T585 amod direct,cause
R321 T587 T585 prep of,cause
R322 T588 T587 pobj deafness,of
R323 T589 T585 prep in,cause
R324 T590 T591 compound Pendred,syndrome
R325 T591 T589 pobj syndrome,in
R326 T592 T561 punct .,demonstrate
R744 T1314 T1315 det The,potential
R746 T1316 T1315 amod endocochlear,potential
R747 T1318 T1315 cc and,potential

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T144 38-47 GO:0030849 denotes autosomal
T145 129-138 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T146 142-149 PR_EXT:000015039 denotes SLC26A4
T147 157-162 SO_EXT:sequence_coding_function denotes codes
T148 167-174 PR_EXT:000015039 denotes pendrin
T149 217-224 PR_EXT:000015039 denotes pendrin
T150 244-248 NCBITaxon:10088 denotes mice
T151 260-267 PR_EXT:000015039 denotes Slc26a4
T152 267-268 SO_EXT:normal_or_wild_type_or_present denotes +
T153 269-270 SO_EXT:normal_or_wild_type_or_present denotes +
T154 291-298 PR_EXT:000015039 denotes Slc26a4
T155 299-303 SO_EXT:0000704 denotes gene
T156 305-312 PR_EXT:000015039 denotes Slc26a4
T157 312-313 SO_EXT:sequence_nullness_or_absence denotes -
T158 314-315 SO_EXT:sequence_nullness_or_absence denotes -
T159 327-337 GO:0010467 denotes Expression
T160 341-348 PR_EXT:000015039 denotes pendrin
T161 359-367 CHEBI_PR_EXT:protein denotes proteins
T162 416-426 GO:0010467 denotes Expression
T163 430-434 CHEBI_SO_EXT:mRNA denotes mRNA
T164 466-468 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T165 523-525 CHEBI:29103 denotes K+
T166 618-623 UBERON:0002282 denotes stria
T167 618-638 CL:0002492 denotes stria marginal cells
T168 633-638 CL_GO_EXT:cell denotes cells
T169 677-683 UBERON:0000479 denotes Tissue
T170 748-760 GO_PATO_EXT:biological_pigmentation_process_or_quality denotes pigmentation
T171 802-809 PR_EXT:000015039 denotes Pendrin
T172 827-834 UBERON:0001844 denotes cochlea
T173 838-857 _FRAGMENT denotes apical membranes of
T174 876-881 GO:0016324 denotes cells
T175 858-875 UBERON:0028194 denotes spiral prominence
T176 876-881 CL_GO_EXT:cell denotes cells
T177 901-906 CL_GO_EXT:cell denotes cells
T178 910-926 UBERON:0002282 denotes stria vascularis
T179 931-943 UBERON:0008832 denotes outer sulcus
T180 953-958 CL_GO_EXT:cell denotes cells
T181 960-969 UBERON:0001852 denotes Endolymph
T182 980-987 PR_EXT:000015039 denotes Slc26a4
T183 987-988 SO_EXT:sequence_nullness_or_absence denotes -
T184 989-990 SO_EXT:sequence_nullness_or_absence denotes -
T185 991-995 NCBITaxon:10088 denotes mice
T186 1014-1020 UBERON:0000479 denotes tissue
T187 1058-1064 _FRAGMENT denotes type I
T188 1072-1082 CL:0002670 denotes fibrocytes
T189 1058-1062 _FRAGMENT denotes type
T190 1069-1082 CL:0002666 denotes II fibrocytes
T191 1097-1104 PR_EXT:000015039 denotes Slc26a4
T192 1104-1105 SO_EXT:sequence_nullness_or_absence denotes -
T193 1106-1107 SO_EXT:sequence_nullness_or_absence denotes -
T194 1108-1112 NCBITaxon:10088 denotes mice
T195 1178-1188 CL:0000646 denotes basal cell
T196 1184-1188 CL_GO_EXT:cell denotes cell
T197 1204-1206 CHEBI:29103 denotes K+
T198 1204-1214 GO_EXT:0005267 denotes K+ channel
T199 1215-1221 PR_EXT:000001979 denotes KCNJ10
T200 1222-1231 GO_PATO_EXT:biological_localization_process_or_quality denotes localized
T201 1235-1253 CL:0002486 denotes intermediate cells
T202 1248-1253 CL_GO_EXT:cell denotes cells
T203 1255-1271 UBERON:0002282 denotes Stria vascularis
T204 1281-1290 CHEBI_EXT:26130 denotes pigmented
T205 1316-1328 CHEBI:26519 denotes free radical
T206 1341-1351 CL:0000646 denotes basal cell
T207 1347-1351 CL_GO_EXT:cell denotes cell
T208 1377-1395 CL:0002486 denotes intermediate cells
T209 1390-1395 CL_GO_EXT:cell denotes cells
T210 1400-1406 PR_EXT:000001979 denotes KCNJ10
T211 1407-1411 CHEBI_SO_EXT:mRNA denotes mRNA
T212 1429-1435 PR_EXT:000001979 denotes KCNJ10
T213 1436-1443 CHEBI_PR_EXT:protein denotes protein
T214 1456-1469 UBERON:0001852 denotes Endolymphatic
T215 1470-1472 CHEBI:29103 denotes K+
T216 1504-1512 GO:0016020 denotes membrane
T217 1513-1521 CHEBI_PR_EXT:protein denotes proteins
T218 1536-1538 CHEBI:29103 denotes K+
T219 1539-1548 GO_EXT:secretion_entity_or_process denotes secretion
T220 1577-1579 CHEBI:29103 denotes K+
T221 1577-1587 GO_EXT:0005267 denotes K+ channel
T222 1588-1593 PR_EXT:000000728 denotes KCNQ1
T223 1598-1603 PR_EXT:000009255 denotes KCNE1
T224 1605-1608 CHEBI:29101 denotes Na+
T225 1605-1630 GO_EXT:0008511 denotes Na+/2Cl-/K+ cotransporter
T226 1614-1616 CHEBI:29103 denotes K+
T227 1631-1638 PR_EXT:000014925 denotes SLC12A2
T228 1647-1659 GO:0005921 denotes gap junction
T229 1660-1664 PR_EXT:000007998 denotes GJB2
T230 1715-1722 PR_EXT:000015039 denotes pendrin
T231 1754-1760 PR_EXT:000001979 denotes KCNJ10
T232 1761-1768 CHEBI_PR_EXT:protein denotes protein
T233 1769-1779 GO:0010467 denotes expression
T1268 509-522 UBERON:0001852 denotes endolymphatic
R4 T174 T173 _lexicallyChainedTo cells,apical membranes of
R5 T188 T187 _lexicallyChainedTo fibrocytes,type I
R6 T190 T189 _lexicallyChainedTo II fibrocytes,type

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T81 38-47 GO:0030849 denotes autosomal
T82 142-149 PR:000015039 denotes SLC26A4
T83 167-174 PR:000015039 denotes pendrin
T84 217-224 PR:000015039 denotes pendrin
T85 244-248 NCBITaxon:10088 denotes mice
T86 260-267 PR:000015039 denotes Slc26a4
T87 291-298 PR:000015039 denotes Slc26a4
T88 299-303 SO:0000704 denotes gene
T89 305-312 PR:000015039 denotes Slc26a4
T90 327-337 GO:0010467 denotes Expression
T91 341-348 PR:000015039 denotes pendrin
T92 416-426 GO:0010467 denotes Expression
T93 523-525 CHEBI:29103 denotes K+
T94 618-623 UBERON:0002282 denotes stria
T95 618-638 CL:0002492 denotes stria marginal cells
T96 677-683 UBERON:0000479 denotes Tissue
T97 802-809 PR:000015039 denotes Pendrin
T98 827-834 UBERON:0001844 denotes cochlea
T99 838-857 _FRAGMENT denotes apical membranes of
T100 876-881 GO:0016324 denotes cells
T101 858-875 UBERON:0028194 denotes spiral prominence
T102 910-926 UBERON:0002282 denotes stria vascularis
T103 931-943 UBERON:0008832 denotes outer sulcus
T104 960-969 UBERON:0001852 denotes Endolymph
T105 980-987 PR:000015039 denotes Slc26a4
T106 991-995 NCBITaxon:10088 denotes mice
T107 1014-1020 UBERON:0000479 denotes tissue
T108 1058-1064 _FRAGMENT denotes type I
T109 1072-1082 CL:0002670 denotes fibrocytes
T110 1058-1062 _FRAGMENT denotes type
T111 1069-1082 CL:0002666 denotes II fibrocytes
T112 1097-1104 PR:000015039 denotes Slc26a4
T113 1108-1112 NCBITaxon:10088 denotes mice
T114 1178-1188 CL:0000646 denotes basal cell
T115 1204-1206 CHEBI:29103 denotes K+
T116 1215-1221 PR:000001979 denotes KCNJ10
T117 1235-1253 CL:0002486 denotes intermediate cells
T118 1255-1271 UBERON:0002282 denotes Stria vascularis
T119 1281-1290 CHEBI:26130 denotes pigmented
T120 1316-1328 CHEBI:26519 denotes free radical
T121 1341-1351 CL:0000646 denotes basal cell
T122 1377-1395 CL:0002486 denotes intermediate cells
T123 1400-1406 PR:000001979 denotes KCNJ10
T124 1429-1435 PR:000001979 denotes KCNJ10
T125 1456-1469 UBERON:0001852 denotes Endolymphatic
T126 1470-1472 CHEBI:29103 denotes K+
T127 1504-1512 GO:0016020 denotes membrane
T128 1536-1538 CHEBI:29103 denotes K+
T129 1577-1579 CHEBI:29103 denotes K+
T130 1588-1593 PR:000000728 denotes KCNQ1
T131 1598-1603 PR:000009255 denotes KCNE1
T132 1605-1608 CHEBI:29101 denotes Na+
T133 1614-1616 CHEBI:29103 denotes K+
T134 1631-1638 PR:000014925 denotes SLC12A2
T135 1647-1659 GO:0005921 denotes gap junction
T136 1660-1664 PR:000007998 denotes GJB2
T137 1715-1722 PR:000015039 denotes pendrin
T138 1754-1760 PR:000001979 denotes KCNJ10
T139 1769-1779 GO:0010467 denotes expression
T1244 509-522 UBERON:0001852 denotes endolymphatic
R1 T100 T99 _lexicallyChainedTo cells,apical membranes of
R2 T109 T108 _lexicallyChainedTo fibrocytes,type I
R3 T111 T110 _lexicallyChainedTo II fibrocytes,type