PMC:5126056 / 81050-81956 JSONTXT

{"project":"0_colil","denotations":[{"id":"27965528-22122861-246968","span":{"begin":137,"end":141},"obj":"22122861"},{"id":"27965528-18081554-246969","span":{"begin":174,"end":178},"obj":"18081554"},{"id":"27965528-22122861-246970","span":{"begin":344,"end":348},"obj":"22122861"},{"id":"27965528-26162607-246971","span":{"begin":480,"end":484},"obj":"26162607"},{"id":"27965528-18081554-246972","span":{"begin":617,"end":621},"obj":"18081554"},{"id":"27965528-19699772-246973","span":{"begin":687,"end":691},"obj":"19699772"},{"id":"27965528-26162607-246974","span":{"begin":784,"end":788},"obj":"26162607"}],"text":"NMU has been characterized in Cypriniformes (carp, goldfish) and Perciformes (orange-spotted grouper). In both common carp (Kono et al., 2012) and goldfish (Maruyama et al., 2008), several forms of NMU (3–5) have been isolated and their mRNA expressions shown to decrease upon fasting, suggesting a role in feeding and metabolism (Kono et al., 2012). Similarly, in orange-spotted grouper, hypothalamic NMU mRNA levels decrease in fasted fish and increase post-feeding (Li et al., 2015), suggesting an anorexigenic role. In goldfish, central injections of NMU inhibit feeding and locomotor behaviors (Maruyama et al., 2008) and increase brain CRF mRNA expression levels (Maruyama et al., 2009) and in grouper, IP injections of NMU down-regulate hypothalamic NPY expression (Li et al., 2015), suggesting that the anorexigenic actions of NMU are mediated by the CRF system and an inhibition of the NPY system."}

{"project":"2_test","denotations":[{"id":"27965528-22122861-38190902","span":{"begin":137,"end":141},"obj":"22122861"},{"id":"27965528-18081554-38190903","span":{"begin":174,"end":178},"obj":"18081554"},{"id":"27965528-22122861-38190904","span":{"begin":344,"end":348},"obj":"22122861"},{"id":"27965528-26162607-38190905","span":{"begin":480,"end":484},"obj":"26162607"},{"id":"27965528-18081554-38190906","span":{"begin":617,"end":621},"obj":"18081554"},{"id":"27965528-19699772-38190907","span":{"begin":687,"end":691},"obj":"19699772"},{"id":"27965528-26162607-38190908","span":{"begin":784,"end":788},"obj":"26162607"}],"text":"NMU has been characterized in Cypriniformes (carp, goldfish) and Perciformes (orange-spotted grouper). In both common carp (Kono et al., 2012) and goldfish (Maruyama et al., 2008), several forms of NMU (3–5) have been isolated and their mRNA expressions shown to decrease upon fasting, suggesting a role in feeding and metabolism (Kono et al., 2012). Similarly, in orange-spotted grouper, hypothalamic NMU mRNA levels decrease in fasted fish and increase post-feeding (Li et al., 2015), suggesting an anorexigenic role. In goldfish, central injections of NMU inhibit feeding and locomotor behaviors (Maruyama et al., 2008) and increase brain CRF mRNA expression levels (Maruyama et al., 2009) and in grouper, IP injections of NMU down-regulate hypothalamic NPY expression (Li et al., 2015), suggesting that the anorexigenic actions of NMU are mediated by the CRF system and an inhibition of the NPY system."}