PMC:5126056 / 77388-78426 JSONTXT

{"project":"0_colil","denotations":[{"id":"27965528-16306385-246952","span":{"begin":271,"end":275},"obj":"16306385"},{"id":"27965528-23504102-246953","span":{"begin":381,"end":385},"obj":"23504102"},{"id":"27965528-16135090-246954","span":{"begin":509,"end":513},"obj":"16135090"},{"id":"27965528-19456363-246955","span":{"begin":594,"end":598},"obj":"19456363"},{"id":"27965528-19800340-246956","span":{"begin":835,"end":839},"obj":"19800340"},{"id":"27965528-23261992-246957","span":{"begin":1032,"end":1036},"obj":"23261992"}],"text":"Endocanabinoid system\nIn mammals, the endocannabinoid system (ECS), which consists of cannabinoid receptors (CB1 and CB2) and endogenous cannabinoids, is involved in the regulation of several physiological functions, including feeding and energy balance (Pagotto et al., 2006).\nIn goldfish, CB1 and CB2 are both expressed in brain, where CB1 co-localizes with NPY (Cottone et al., 2013). Treatment with low doses of the endocannabinoid receptor agonist anandamide (AEA) increases food intake (Valenti et al., 2005), and food deprivation increases CB1 and AEA brain mRNA levels (Cottone et al., 2009), suggesting the involvement of the ECS in the control of energy intake in Cypriniforme. Similarly, in sea bream Sparus aurata (Perciforme), AEA administered via water increases food intake and NPY brain mRNA levels (Piccinetti et al., 2010). In common sole, Solea solea (Pleuronectiforme), feeding fish with dietary nucleotides reduce CB1 brain transcript levels, suggesting that feeding and diets modulate the ECS (Palermo et al., 2013)."}

{"project":"2_test","denotations":[{"id":"27965528-16306385-38190886","span":{"begin":271,"end":275},"obj":"16306385"},{"id":"27965528-23504102-38190887","span":{"begin":381,"end":385},"obj":"23504102"},{"id":"27965528-16135090-38190888","span":{"begin":509,"end":513},"obj":"16135090"},{"id":"27965528-19456363-38190889","span":{"begin":594,"end":598},"obj":"19456363"},{"id":"27965528-19800340-38190890","span":{"begin":835,"end":839},"obj":"19800340"},{"id":"27965528-23261992-38190891","span":{"begin":1032,"end":1036},"obj":"23261992"}],"text":"Endocanabinoid system\nIn mammals, the endocannabinoid system (ECS), which consists of cannabinoid receptors (CB1 and CB2) and endogenous cannabinoids, is involved in the regulation of several physiological functions, including feeding and energy balance (Pagotto et al., 2006).\nIn goldfish, CB1 and CB2 are both expressed in brain, where CB1 co-localizes with NPY (Cottone et al., 2013). Treatment with low doses of the endocannabinoid receptor agonist anandamide (AEA) increases food intake (Valenti et al., 2005), and food deprivation increases CB1 and AEA brain mRNA levels (Cottone et al., 2009), suggesting the involvement of the ECS in the control of energy intake in Cypriniforme. Similarly, in sea bream Sparus aurata (Perciforme), AEA administered via water increases food intake and NPY brain mRNA levels (Piccinetti et al., 2010). In common sole, Solea solea (Pleuronectiforme), feeding fish with dietary nucleotides reduce CB1 brain transcript levels, suggesting that feeding and diets modulate the ECS (Palermo et al., 2013)."}