PMC:5126056 / 36648-38296
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5126056","sourcedb":"PMC","sourceid":"5126056","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5126056","text":"In both goldfish (Volkoff et al., 1999; Nakamachi et al., 2006; Facciolo et al., 2011) and zebrafish (Danio rerio) (Yokobori et al., 2011) (Cypriniformes), and cavefish (Astyanax mexicanus) (Characiforme) (Penney and Volkoff, 2014), orexin injections increase searching/feeding behaviors. In orange-spotted grouper (Perciforme), intraperitoneal (IP) orexin injections increase hypothalamic mRNA expression levels of NPY, a major appetite stimulator (Yan et al., 2011), further suggesting an orexigenic role. However, in ornate wrasse (Thalassoma pavo) (Perciforme), orexin IP injections induce increases in locomotion but decreases in feeding (Facciolo et al., 2009), suggesting that the major role of orexin might be induction of hyperactivity rather than increasing food ingestion. Indeed, in goldfish, hypothalamic orexin mRNA expression levels peak when fish are active prior to a scheduled meal (Hoskins and Volkoff, 2012) and in zebrafish, increased locomotor activity is associated with increased activity of hypothalamic orexin neurons (Naumann et al., 2010) and larvae overexpressing orexin are hyperactive (Woods et al., 2014). Similarly, orexin expression decreases post-feeding in Characiformes [cavefish (Wall and Volkoff, 2013), dourado (Salminus brasiliensis) (Volkoff et al., 2016) and pacu (Piaractus mesopotamicus) (Volkoff et al., 2017)] and is higher at mealtime in orange-spotted grouper (Yan et al., 2011) and tilapia (Chen et al., 2011) (Perciformes), as well as Atlantic cod (Gadiforme) (Xu and Volkoff, 2007). In cod, orexin levels are also higher during daylight hours, when animals are active (Hoskins and Volkoff, 2012).","tracks":[{"project":"0_colil","denotations":[{"id":"27965528-10556637-246655","span":{"begin":34,"end":38},"obj":"10556637"},{"id":"27965528-16503924-246656","span":{"begin":58,"end":62},"obj":"16503924"},{"id":"27965528-22001787-246657","span":{"begin":81,"end":85},"obj":"22001787"},{"id":"27965528-21616109-246658","span":{"begin":133,"end":137},"obj":"21616109"},{"id":"27965528-24287340-246659","span":{"begin":226,"end":230},"obj":"24287340"},{"id":"27965528-21600944-246660","span":{"begin":462,"end":466},"obj":"21600944"},{"id":"27965528-18816789-246661","span":{"begin":661,"end":665},"obj":"18816789"},{"id":"27965528-22226758-246662","span":{"begin":922,"end":926},"obj":"22226758"},{"id":"27965528-20305645-246663","span":{"begin":1061,"end":1065},"obj":"20305645"},{"id":"27965528-24573274-246664","span":{"begin":1131,"end":1135},"obj":"24573274"},{"id":"27965528-23305930-246665","span":{"begin":1236,"end":1240},"obj":"23305930"},{"id":"27965528-27468955-246666","span":{"begin":1292,"end":1296},"obj":"27468955"},{"id":"27965528-27717774-246667","span":{"begin":1350,"end":1354},"obj":"27717774"},{"id":"27965528-21600944-246668","span":{"begin":1422,"end":1426},"obj":"21600944"},{"id":"27965528-21698794-246669","span":{"begin":1454,"end":1458},"obj":"21698794"},{"id":"27965528-17434256-246670","span":{"begin":1528,"end":1532},"obj":"17434256"},{"id":"27965528-22226758-246671","span":{"begin":1642,"end":1646},"obj":"22226758"}],"attributes":[{"subj":"27965528-10556637-246655","pred":"source","obj":"0_colil"},{"subj":"27965528-16503924-246656","pred":"source","obj":"0_colil"},{"subj":"27965528-22001787-246657","pred":"source","obj":"0_colil"},{"subj":"27965528-21616109-246658","pred":"source","obj":"0_colil"},{"subj":"27965528-24287340-246659","pred":"source","obj":"0_colil"},{"subj":"27965528-21600944-246660","pred":"source","obj":"0_colil"},{"subj":"27965528-18816789-246661","pred":"source","obj":"0_colil"},{"subj":"27965528-22226758-246662","pred":"source","obj":"0_colil"},{"subj":"27965528-20305645-246663","pred":"source","obj":"0_colil"},{"subj":"27965528-24573274-246664","pred":"source","obj":"0_colil"},{"subj":"27965528-23305930-246665","pred":"source","obj":"0_colil"},{"subj":"27965528-27468955-246666","pred":"source","obj":"0_colil"},{"subj":"27965528-27717774-246667","pred":"source","obj":"0_colil"},{"subj":"27965528-21600944-246668","pred":"source","obj":"0_colil"},{"subj":"27965528-21698794-246669","pred":"source","obj":"0_colil"},{"subj":"27965528-17434256-246670","pred":"source","obj":"0_colil"},{"subj":"27965528-22226758-246671","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"27965528-10556637-38190589","span":{"begin":34,"end":38},"obj":"10556637"},{"id":"27965528-16503924-38190590","span":{"begin":58,"end":62},"obj":"16503924"},{"id":"27965528-22001787-38190591","span":{"begin":81,"end":85},"obj":"22001787"},{"id":"27965528-21616109-38190592","span":{"begin":133,"end":137},"obj":"21616109"},{"id":"27965528-24287340-38190593","span":{"begin":226,"end":230},"obj":"24287340"},{"id":"27965528-21600944-38190594","span":{"begin":462,"end":466},"obj":"21600944"},{"id":"27965528-18816789-38190595","span":{"begin":661,"end":665},"obj":"18816789"},{"id":"27965528-22226758-38190596","span":{"begin":922,"end":926},"obj":"22226758"},{"id":"27965528-20305645-38190597","span":{"begin":1061,"end":1065},"obj":"20305645"},{"id":"27965528-24573274-38190598","span":{"begin":1131,"end":1135},"obj":"24573274"},{"id":"27965528-23305930-38190599","span":{"begin":1236,"end":1240},"obj":"23305930"},{"id":"27965528-27468955-38190600","span":{"begin":1292,"end":1296},"obj":"27468955"},{"id":"27965528-27717774-38190601","span":{"begin":1350,"end":1354},"obj":"27717774"},{"id":"27965528-21600944-38190602","span":{"begin":1422,"end":1426},"obj":"21600944"},{"id":"27965528-21698794-38190603","span":{"begin":1454,"end":1458},"obj":"21698794"},{"id":"27965528-17434256-38190604","span":{"begin":1528,"end":1532},"obj":"17434256"},{"id":"27965528-22226758-38190605","span":{"begin":1642,"end":1646},"obj":"22226758"}],"attributes":[{"subj":"27965528-10556637-38190589","pred":"source","obj":"2_test"},{"subj":"27965528-16503924-38190590","pred":"source","obj":"2_test"},{"subj":"27965528-22001787-38190591","pred":"source","obj":"2_test"},{"subj":"27965528-21616109-38190592","pred":"source","obj":"2_test"},{"subj":"27965528-24287340-38190593","pred":"source","obj":"2_test"},{"subj":"27965528-21600944-38190594","pred":"source","obj":"2_test"},{"subj":"27965528-18816789-38190595","pred":"source","obj":"2_test"},{"subj":"27965528-22226758-38190596","pred":"source","obj":"2_test"},{"subj":"27965528-20305645-38190597","pred":"source","obj":"2_test"},{"subj":"27965528-24573274-38190598","pred":"source","obj":"2_test"},{"subj":"27965528-23305930-38190599","pred":"source","obj":"2_test"},{"subj":"27965528-27468955-38190600","pred":"source","obj":"2_test"},{"subj":"27965528-27717774-38190601","pred":"sour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