PMC:5118444 / 28532-29341 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5118444","sourcedb":"PMC","sourceid":"5118444","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5118444","text":"Rates of molecular evolution can be used to understand the selection constraints experienced by genes. In particular, contrasting the rate of protein-changing (non-synonymous) substitution and the rate of silent (synonymous) substitution at the nucleotide level allows us to identify the type of selection acting on individual genes. We measured selective constraint on cattle genes by using the dN/dS ratio. Here, dS denotes the synonymous substitution rate, and dN denotes the nonsynonymous substitution rate. When computed using sequences from divergent species, the dN/dS ratio is a measure of adaptive evolution in protein-coding sequences (Kryazhimskiy and Plotkin, 2008). For this reason we chose to use Homo sapiens as the comparison species since it is a well-studied organism, divergent from cattle.","tracks":[{"project":"2_test","denotations":[{"id":"27920798-19081788-33484702","span":{"begin":672,"end":676},"obj":"19081788"}],"attributes":[{"subj":"27920798-19081788-33484702","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"27920798-19081788-33484702","span":{"begin":672,"end":676},"obj":"19081788"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"27920798-19081788-33484702","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93e9ec","default":true},{"id":"MyTest","color":"#ecd593"}]}]}}