PMC:5118429 / 40193-41473
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5118429","sourcedb":"PMC","sourceid":"5118429","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5118429","text":"A third gene identified by wssGWAS analysis was Fragile X mental retardation gene 1 (Fxr1), an autosomal gene that is highly expressed in muscle (Blonden et al., 2005). Depletion of this gene during early development of the zebrafish leads to cardiomyopathy and muscular dystrophy (Van't Padje et al., 2009). In cultured muscle cells, depletion of Fxr1 reduced myoblast abundance, suggesting an evolutionarily-conserved role for Fxr1 protein in myogenesis (Davidovic et al., 2013). A fourth gene detected by wssGWAS analysis that may affect myogenic capacity was Ksr1. This gene is a scaffold protein for the Raf/MEK/ERK kinase cascade (Ory et al., 2003). Although, a role of for Ksr1 in muscle has not been demonstrated, activation of the Raf/Mek/ERK kinase cascade promotes proliferation of myogenic cells (Knight and Kothary, 2011). A final gene that may affect myogenesis was Proviral integration site 1 (Pim1), a gene that, when overexpressed in cardiomyocytes, causes increases in regenerative capacity and increases the pool of progenitor cells (Del Re and Sadoshima, 2012), although it is unknown if this gene has significance in skeletal muscle. However, expression of Pim1 has been positively correlated with intramuscular fat content in steers (Sadkowski et al., 2014).","tracks":[{"project":"2_test","denotations":[{"id":"27920797-15968590-33226506","span":{"begin":162,"end":166},"obj":"15968590"},{"id":"27920797-19648401-33226507","span":{"begin":302,"end":306},"obj":"19648401"},{"id":"27920797-23555284-33226508","span":{"begin":475,"end":479},"obj":"23555284"},{"id":"27920797-12932319-33226509","span":{"begin":649,"end":653},"obj":"12932319"},{"id":"27920797-21902831-33226510","span":{"begin":829,"end":833},"obj":"21902831"},{"id":"27920797-22539751-33226511","span":{"begin":1075,"end":1079},"obj":"22539751"},{"id":"27920797-24491505-33226512","span":{"begin":1274,"end":1278},"obj":"24491505"}],"attributes":[{"subj":"27920797-15968590-33226506","pred":"source","obj":"2_test"},{"subj":"27920797-19648401-33226507","pred":"source","obj":"2_test"},{"subj":"27920797-23555284-33226508","pred":"source","obj":"2_test"},{"subj":"27920797-12932319-33226509","pred":"source","obj":"2_test"},{"subj":"27920797-21902831-33226510","pred":"source","obj":"2_test"},{"subj":"27920797-22539751-33226511","pred":"source","obj":"2_test"},{"subj":"27920797-24491505-33226512","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"27920797-15968590-33226506","span":{"begin":162,"end":166},"obj":"15968590"},{"id":"27920797-19648401-33226507","span":{"begin":302,"end":306},"obj":"19648401"},{"id":"27920797-23555284-33226508","span":{"begin":475,"end":479},"obj":"23555284"},{"id":"27920797-12932319-33226509","span":{"begin":649,"end":653},"obj":"12932319"},{"id":"27920797-21902831-33226510","span":{"begin":829,"end":833},"obj":"21902831"},{"id":"27920797-22539751-33226511","span":{"begin":1075,"end":1079},"obj":"22539751"},{"id":"27920797-24491505-33226512","span":{"begin":1274,"end":1278},"obj":"24491505"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"27920797-15968590-33226506","pred":"source","obj":"MyTest"},{"subj":"27920797-19648401-33226507","pred":"source","obj":"MyTest"},{"subj":"27920797-23555284-33226508","pred":"source","obj":"MyTest"},{"subj":"27920797-12932319-33226509","pred":"source","obj":"MyTest"},{"subj":"27920797-21902831-33226510","pred":"source","obj":"MyTest"},{"subj":"27920797-22539751-33226511","pred":"source","obj":"MyTest"},{"subj":"27920797-24491505-33226512","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#aa93ec","default":true},{"id":"MyTest","color":"#95ec93"}]}]}}