PMC:5118426 / 36709-37823
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5118426","sourcedb":"PMC","sourceid":"5118426","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5118426","text":"The wake period of normal mice was found to be increased with administration of UDCA that also decreased slow wave sleep (Yanovsky et al., 2012). In contrast, administration of UDCA to histidine decarboxylase knockout mice, that are deficient in histamine that stimulates arousal, decreased wakefulness and altered cortical EEG and sleep-wake parameters. Using in vitro patch-clamp recordings from histaminergic neurons, UDCA was found to inhibit GABAergic currents and to serve as an antagonist for GABAA receptors expressed in HEK293 cells. In one of the few studies to analyze more than one or two bile acids, a structure-function relationship analysis was performed using cultured hypothalamic neurons (Schubring et al., 2012). Bile acids were found to modulate firing frequency and synchrony, and to block activity of GABAA and NMDA receptors. Antagonist activity for both the GABAA and NMDA receptors was strongest for CDCA followed by DCA, CA, and dehydrocholate. Involvement of bile acid binding to TGR5 was excluded as a potential mechanism in the neurotransmitter receptor blockade (Keitel et al., 2010).","tracks":[{"project":"MyTest","denotations":[{"id":"27920719-22880010-31054393","span":{"begin":139,"end":143},"obj":"22880010"},{"id":"27920719-22155097-31054394","span":{"begin":725,"end":729},"obj":"22155097"},{"id":"27920719-20665558-31054395","span":{"begin":1108,"end":1112},"obj":"20665558"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"27920719-22880010-31054393","pred":"source","obj":"MyTest"},{"subj":"27920719-22155097-31054394","pred":"source","obj":"MyTest"},{"subj":"27920719-20665558-31054395","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"27920719-22880010-31054393","span":{"begin":139,"end":143},"obj":"22880010"},{"id":"27920719-22155097-31054394","span":{"begin":725,"end":729},"obj":"22155097"},{"id":"27920719-20665558-31054395","span":{"begin":1108,"end":1112},"obj":"20665558"}],"attributes":[{"subj":"27920719-22880010-31054393","pred":"source","obj":"2_test"},{"subj":"27920719-22155097-31054394","pred":"source","obj":"2_test"},{"subj":"27920719-20665558-31054395","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ecc793","default":true},{"id":"2_test","color":"#ad93ec"}]}]}}