PMC:5118421 / 30448-31040 JSONTXT

{"project":"TEST0","denotations":[{"id":"27920779-233-239-3100259","span":{"begin":257,"end":259},"obj":"[\"15860590\", \"20882016\", \"23940276\"]"},{"id":"27920779-230-236-3100260","span":{"begin":264,"end":266},"obj":"[\"23359068\", \"20018688\", \"21908739\", \"23825311\", \"25355869\", \"24614107\", \"23552890\"]"}],"text":"In view of reports that a measure of autoreactivity may be beneficial in the context of some antiviral antibody responses, we asked whether somatic mutations that generate Arg codons arise frequently in antiviral antibodies, and specifically at AGY codons (37–39, 42–48). While it was not possible to clearly address this question in the context of broadly neutralizing anti-HIV antibodies, we were able to address it in the context of Abs directed against six different viruses. In every case, mutations producing Arg codons were present, often in abundance, and predominantly at AGY codons."}

{"project":"2_test","denotations":[{"id":"27920779-15860590-34707982","span":{"begin":257,"end":259},"obj":"15860590"},{"id":"27920779-20882016-34707982","span":{"begin":257,"end":259},"obj":"20882016"},{"id":"27920779-23940276-34707982","span":{"begin":257,"end":259},"obj":"23940276"},{"id":"27920779-23359068-34707983","span":{"begin":264,"end":266},"obj":"23359068"},{"id":"27920779-20018688-34707983","span":{"begin":264,"end":266},"obj":"20018688"},{"id":"27920779-21908739-34707983","span":{"begin":264,"end":266},"obj":"21908739"},{"id":"27920779-23825311-34707983","span":{"begin":264,"end":266},"obj":"23825311"},{"id":"27920779-25355869-34707983","span":{"begin":264,"end":266},"obj":"25355869"},{"id":"27920779-24614107-34707983","span":{"begin":264,"end":266},"obj":"24614107"},{"id":"27920779-23552890-34707983","span":{"begin":264,"end":266},"obj":"23552890"}],"text":"In view of reports that a measure of autoreactivity may be beneficial in the context of some antiviral antibody responses, we asked whether somatic mutations that generate Arg codons arise frequently in antiviral antibodies, and specifically at AGY codons (37–39, 42–48). While it was not possible to clearly address this question in the context of broadly neutralizing anti-HIV antibodies, we were able to address it in the context of Abs directed against six different viruses. In every case, mutations producing Arg codons were present, often in abundance, and predominantly at AGY codons."}

{"project":"MyTest","denotations":[{"id":"27920779-15860590-34707982","span":{"begin":257,"end":259},"obj":"15860590"},{"id":"27920779-20882016-34707982","span":{"begin":257,"end":259},"obj":"20882016"},{"id":"27920779-23940276-34707982","span":{"begin":257,"end":259},"obj":"23940276"},{"id":"27920779-23359068-34707983","span":{"begin":264,"end":266},"obj":"23359068"},{"id":"27920779-20018688-34707983","span":{"begin":264,"end":266},"obj":"20018688"},{"id":"27920779-21908739-34707983","span":{"begin":264,"end":266},"obj":"21908739"},{"id":"27920779-23825311-34707983","span":{"begin":264,"end":266},"obj":"23825311"},{"id":"27920779-25355869-34707983","span":{"begin":264,"end":266},"obj":"25355869"},{"id":"27920779-24614107-34707983","span":{"begin":264,"end":266},"obj":"24614107"},{"id":"27920779-23552890-34707983","span":{"begin":264,"end":266},"obj":"23552890"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"In view of reports that a measure of autoreactivity may be beneficial in the context of some antiviral antibody responses, we asked whether somatic mutations that generate Arg codons arise frequently in antiviral antibodies, and specifically at AGY codons (37–39, 42–48). While it was not possible to clearly address this question in the context of broadly neutralizing anti-HIV antibodies, we were able to address it in the context of Abs directed against six different viruses. In every case, mutations producing Arg codons were present, often in abundance, and predominantly at AGY codons."}