PMC:5118421 / 12149-12626 JSONTXT

{"project":"TEST0","denotations":[{"id":"27920779-108-113-3100221","span":{"begin":108,"end":109},"obj":"[\"8011289\"]"},{"id":"27920779-77-82-3100222","span":{"begin":189,"end":190},"obj":"[\"20805563\"]"},{"id":"27920779-80-86-3100223","span":{"begin":192,"end":194},"obj":"[\"23181829\", \"18677426\", \"18621685\", \"15968001\"]"},{"id":"27920779-193-198-3100224","span":{"begin":305,"end":306},"obj":"[\"20805563\"]"},{"id":"27920779-159-164-3100225","span":{"begin":468,"end":469},"obj":"[\"20805563\", \"25634361\", \"8011289\"]"},{"id":"27920779-164-170-3100226","span":{"begin":473,"end":475},"obj":"[\"7651532\"]"}],"text":"It is well established that CDR Arg residues play a major role in specifying the nuclear reactivity of ANA (3). Moreover, in spontaneous SLE, many ANA arise by SHM of non-autoreactive Abs (1, 28–31), and this is often associated with the conversion of CDR germline-encoded AGY Ser codons into Arg codons (1). At the same time, germline IgVH, Vκ, and Vλ genes have unusually high frequencies of AGY Ser codons in CDRs, and this tendency holds for both mice and humans (1–3, 17)."}

{"project":"2_test","denotations":[{"id":"27920779-8011289-34707944","span":{"begin":108,"end":109},"obj":"8011289"},{"id":"27920779-20805563-34707945","span":{"begin":189,"end":190},"obj":"20805563"},{"id":"27920779-23181829-34707946","span":{"begin":192,"end":194},"obj":"23181829"},{"id":"27920779-18677426-34707946","span":{"begin":192,"end":194},"obj":"18677426"},{"id":"27920779-18621685-34707946","span":{"begin":192,"end":194},"obj":"18621685"},{"id":"27920779-15968001-34707946","span":{"begin":192,"end":194},"obj":"15968001"},{"id":"27920779-20805563-34707947","span":{"begin":305,"end":306},"obj":"20805563"},{"id":"27920779-20805563-34707948","span":{"begin":468,"end":469},"obj":"20805563"},{"id":"27920779-25634361-34707948","span":{"begin":468,"end":469},"obj":"25634361"},{"id":"27920779-8011289-34707948","span":{"begin":468,"end":469},"obj":"8011289"},{"id":"27920779-7651532-34707949","span":{"begin":473,"end":475},"obj":"7651532"}],"text":"It is well established that CDR Arg residues play a major role in specifying the nuclear reactivity of ANA (3). Moreover, in spontaneous SLE, many ANA arise by SHM of non-autoreactive Abs (1, 28–31), and this is often associated with the conversion of CDR germline-encoded AGY Ser codons into Arg codons (1). At the same time, germline IgVH, Vκ, and Vλ genes have unusually high frequencies of AGY Ser codons in CDRs, and this tendency holds for both mice and humans (1–3, 17)."}

{"project":"MyTest","denotations":[{"id":"27920779-8011289-34707944","span":{"begin":108,"end":109},"obj":"8011289"},{"id":"27920779-20805563-34707945","span":{"begin":189,"end":190},"obj":"20805563"},{"id":"27920779-23181829-34707946","span":{"begin":192,"end":194},"obj":"23181829"},{"id":"27920779-18677426-34707946","span":{"begin":192,"end":194},"obj":"18677426"},{"id":"27920779-18621685-34707946","span":{"begin":192,"end":194},"obj":"18621685"},{"id":"27920779-15968001-34707946","span":{"begin":192,"end":194},"obj":"15968001"},{"id":"27920779-20805563-34707947","span":{"begin":305,"end":306},"obj":"20805563"},{"id":"27920779-20805563-34707948","span":{"begin":468,"end":469},"obj":"20805563"},{"id":"27920779-25634361-34707948","span":{"begin":468,"end":469},"obj":"25634361"},{"id":"27920779-8011289-34707948","span":{"begin":468,"end":469},"obj":"8011289"},{"id":"27920779-7651532-34707949","span":{"begin":473,"end":475},"obj":"7651532"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"It is well established that CDR Arg residues play a major role in specifying the nuclear reactivity of ANA (3). Moreover, in spontaneous SLE, many ANA arise by SHM of non-autoreactive Abs (1, 28–31), and this is often associated with the conversion of CDR germline-encoded AGY Ser codons into Arg codons (1). At the same time, germline IgVH, Vκ, and Vλ genes have unusually high frequencies of AGY Ser codons in CDRs, and this tendency holds for both mice and humans (1–3, 17)."}