PMC:5097349 / 8906-9963 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5097349","sourcedb":"PMC","sourceid":"5097349","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5097349","text":"Typical MRI findings included marked signal periventricular changes, atrophy of the bulbar region and upper cervical spinal cord in adult AxD [2, 7]. Approximately 90 % cases showed marked medullary atrophy and 50 % had deep white matter lesions or periventricular changes [5]. Farina et al. reported that patients under 40 years old were easier to have periventricular white matter abnormalities and postcontrast enhancement than patients over 40, which showed different levels of abnormal diffusivity On DWI, but some cases were normal [8]. In our case, MRI findings showed the severe atrophy in bulbar region and thoracic spinal cord, but mild atrophy in cervical spinal cord, which is rare in the adult AxD. On DWI, our patient had slightly hyperintensity of extensive periventricular white matter. The lesions without gadolinium enhancement might be related to the decreased amounts and limited distribution of rosenthal fibers [8]. It should be stressed that MRI findings in our case was atypical despite of the lesion locating in the typical regions.","tracks":[{"project":"AxD_symptoms","denotations":[{"id":"T26","span":{"begin":354,"end":396},"obj":"Phenotype"},{"id":"T27","span":{"begin":916,"end":932},"obj":"Phenotype"}],"attributes":[{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0002518"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0100320"},{"subj":"T26","pred":"source","obj":"AxD_symptoms"},{"subj":"T27","pred":"source","obj":"AxD_symptoms"}]},{"project":"2_test","denotations":[{"id":"27814755-18684770-12819179","span":{"begin":143,"end":144},"obj":"18684770"},{"id":"27814755-20721574-12819180","span":{"begin":146,"end":147},"obj":"20721574"},{"id":"27814755-20359319-12819181","span":{"begin":274,"end":275},"obj":"20359319"},{"id":"27814755-18388212-12819182","span":{"begin":539,"end":540},"obj":"18388212"},{"id":"27814755-18388212-12819183","span":{"begin":934,"end":935},"obj":"18388212"}],"attributes":[{"subj":"27814755-18684770-12819179","pred":"source","obj":"2_test"},{"subj":"27814755-20721574-12819180","pred":"source","obj":"2_test"},{"subj":"27814755-20359319-12819181","pred":"source","obj":"2_test"},{"subj":"27814755-18388212-12819182","pred":"source","obj":"2_test"},{"subj":"27814755-18388212-12819183","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AxD_symptoms","color":"#9394ec","default":true},{"id":"2_test","color":"#aeec93"}]}]}}