PMC:509410 / 4242-10852 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T2006	4599-4603	JJ	denotes	fast
T1279	0-10	NN	denotes	Activation
T1280	20-25	VBZ	denotes	Leads
T1281	11-13	IN	denotes	of
T1282	14-19	NN	denotes	PPARδ
T1283	26-28	IN	denotes	to
T1284	29-35	NN	denotes	Muscle
T1285	36-41	NN	denotes	Fiber
T1286	42-56	NN	denotes	Transformation
T1287	56-227	sentence	denotes	A role of PPARδ in muscle fiber was suggested by its enhanced expression—at levels 10-fold and 50-fold greater than PPARα and γ isoforms, respectively (unpublished data).
T1288	57-58	DT	denotes	A
T1289	59-63	NN	denotes	role
T1290	93-102	VBN	denotes	suggested
T1291	64-66	IN	denotes	of
T1292	67-72	NN	denotes	PPARδ
T1293	73-75	IN	denotes	in
T1294	76-82	NN	denotes	muscle
T1295	83-88	NN	denotes	fiber
T1296	89-92	VBD	denotes	was
T1297	103-105	IN	denotes	by
T1298	106-109	PRP$	denotes	its
T1299	119-129	NN	denotes	expression
T1300	110-118	VBN	denotes	enhanced
T1301	129-130	HYPH	denotes	—
T1302	130-132	IN	denotes	at
T1303	133-139	NNS	denotes	levels
T1304	140-142	CD	denotes	10
T1305	160-167	JJR	denotes	greater
T1306	142-143	HYPH	denotes	-
T1307	143-147	RB	denotes	fold
T1308	148-151	CC	denotes	and
T1309	152-154	CD	denotes	50
T1310	154-155	HYPH	denotes	-
T1311	155-159	RB	denotes	fold
T1312	168-172	IN	denotes	than
T1313	173-178	NN	denotes	PPARα
T1314	185-193	NNS	denotes	isoforms
T1315	179-182	CC	denotes	and
T1316	183-184	SYM	denotes	γ
T1317	193-195	,	denotes	,
T1318	195-207	RB	denotes	respectively
T1319	208-209	-LRB-	denotes	(
T1320	221-225	NNS	denotes	data
T1321	209-220	JJ	denotes	unpublished
T1322	225-226	-RRB-	denotes	)
T1323	226-227	.	denotes	.
T1324	227-541	sentence	denotes	An examination of PPARδ in different muscle fibers reveals a significantly higher level in type I muscle (soleus) relative to type II–rich muscle (extensor digitorum longus) or type I and type II mixed muscle (gastrocnemius) (Figure 1A); this expression pattern closely resembles that of PGC-1α (Lin et al. 2002).
T1325	228-230	DT	denotes	An
T1326	231-242	NN	denotes	examination
T1327	279-286	VBZ	denotes	reveals
T1328	243-245	IN	denotes	of
T1329	246-251	NN	denotes	PPARδ
T1330	252-254	IN	denotes	in
T1331	255-264	JJ	denotes	different
T1332	272-278	NNS	denotes	fibers
T1333	265-271	NN	denotes	muscle
T1334	498-507	VBZ	denotes	resembles
T1335	287-288	DT	denotes	a
T1336	310-315	NN	denotes	level
T1337	289-302	RB	denotes	significantly
T1338	303-309	JJR	denotes	higher
T1339	316-318	IN	denotes	in
T1340	319-323	NN	denotes	type
T1341	326-332	NN	denotes	muscle
T1342	324-325	CD	denotes	I
T1343	333-334	-LRB-	denotes	(
T1344	334-340	NN	denotes	soleus
T1345	340-341	-RRB-	denotes	)
T1346	342-350	JJ	denotes	relative
T1347	351-353	IN	denotes	to
T1348	354-358	NN	denotes	type
T1349	362-366	JJ	denotes	rich
T1350	359-361	CD	denotes	II
T1351	361-362	HYPH	denotes	–
T1352	367-373	NN	denotes	muscle
T1353	374-375	-LRB-	denotes	(
T1354	394-400	NN	denotes	longus
T1355	375-383	NN	denotes	extensor
T1356	384-393	NN	denotes	digitorum
T1357	400-401	-RRB-	denotes	)
T1358	402-404	CC	denotes	or
T1359	405-409	NN	denotes	type
T1360	430-436	NN	denotes	muscle
T1361	410-411	CD	denotes	I
T1362	412-415	CC	denotes	and
T1363	416-420	NN	denotes	type
T1364	421-423	CD	denotes	II
T1365	424-429	JJ	denotes	mixed
T1366	437-438	-LRB-	denotes	(
T1367	438-451	NN	denotes	gastrocnemius
T1368	451-452	-RRB-	denotes	)
T1369	453-454	-LRB-	denotes	(
T1370	454-460	NN	denotes	Figure
T1371	461-463	CD	denotes	1A
T1372	463-464	-RRB-	denotes	)
T1373	464-465	,	denotes	;
T1374	466-470	DT	denotes	this
T1375	482-489	NN	denotes	pattern
T1376	471-481	NN	denotes	expression
T1377	490-497	RB	denotes	closely
T1378	508-512	DT	denotes	that
T1379	513-515	IN	denotes	of
T1380	516-519	NN	denotes	PGC
T1381	519-520	HYPH	denotes	-
T1382	520-522	CD	denotes	1α
T1383	523-524	-LRB-	denotes	(
T1384	524-527	NNP	denotes	Lin
T1385	528-530	FW	denotes	et
T1386	531-534	FW	denotes	al.
T1387	535-539	CD	denotes	2002
T1388	539-540	-RRB-	denotes	)
T1389	540-541	.	denotes	.
T1390	541-640	sentence	denotes	A similar pattern but with more pronounced differences was found at the protein level (Figure 1B).
T1391	542-543	DT	denotes	A
T1392	552-559	NN	denotes	pattern
T1393	544-551	JJ	denotes	similar
T1394	601-606	VBN	denotes	found
T1395	560-563	CC	denotes	but
T1396	564-568	IN	denotes	with
T1397	569-573	RBR	denotes	more
T1398	574-584	VBN	denotes	pronounced
T1399	585-596	NNS	denotes	differences
T1400	597-600	VBD	denotes	was
T1401	607-609	IN	denotes	at
T1402	610-613	DT	denotes	the
T1403	622-627	NN	denotes	level
T1404	614-621	NN	denotes	protein
T1405	628-629	-LRB-	denotes	(
T1406	629-635	NN	denotes	Figure
T1407	636-638	CD	denotes	1B
T1408	638-639	-RRB-	denotes	)
T1409	639-640	.	denotes	.
T1410	640-1844	sentence	denotes	Figure 1 Expression of Endogenous PPARδ and VP16-PPARδ Transgene in Muscle (A) Pooled RNA isolated from various muscles of five wild-type male C57B6 mice was hybridized with indicated probes. EDL, extensor digitorum longus; Gastro, gastrocnemius. (B) Pooled nuclear proteins (15 μg/lane) isolated from muscles of five wild-type male C57B6 were probed with anti-PPARδ antibody. RNA polymerase II (Pol II) is shown as a loading control. (C) Expression of the VP16-PPARδ transgene in various tissues. 10 μg of total RNA from each tissue was hybridized with a VP16 cDNA probe. Gastrocnemius muscle was used here. (D) Nuclear proteins (15 μg/lane) isolated from gastrocnemius muscle of the transgenic mice (TG) and the wild-type littermates (WT) were probed with indicated antibodies. The upper, nonspecific band that cross-reacted with the anti-PPARδ antibody serves a loading control. To directly assess the role of activation of PPARδ in control of muscle fiber plasticity and mitochondrial biogenesis, we generated mice expressing a transgene in which the 78-amino-acid VP16 activation domain was fused to the N-terminus of full-length PPARδ, under control of the 2.2-kb human α-skeletal actin promoter.
T1411	1524-1526	TO	denotes	To
T1412	1536-1542	VB	denotes	assess
T1413	1527-1535	RB	denotes	directly
T1414	1646-1655	VBD	denotes	generated
T1415	1543-1546	DT	denotes	the
T1416	1547-1551	NN	denotes	role
T1417	1552-1554	IN	denotes	of
T1418	1555-1565	NN	denotes	activation
T1419	1566-1568	IN	denotes	of
T1420	1569-1574	NN	denotes	PPARδ
T1421	1575-1577	IN	denotes	in
T1422	1578-1585	NN	denotes	control
T1423	1586-1588	IN	denotes	of
T1424	1589-1595	NN	denotes	muscle
T1425	1596-1601	NN	denotes	fiber
T1426	1602-1612	NN	denotes	plasticity
T1427	1613-1616	CC	denotes	and
T1428	1617-1630	JJ	denotes	mitochondrial
T1429	1631-1641	NN	denotes	biogenesis
T1430	1641-1643	,	denotes	,
T1431	1643-1645	PRP	denotes	we
T1432	1656-1660	NNS	denotes	mice
T1433	1661-1671	VBG	denotes	expressing
T1434	1672-1673	DT	denotes	a
T1435	1674-1683	NN	denotes	transgene
T1436	1684-1686	IN	denotes	in
T1437	1738-1743	VBN	denotes	fused
T1438	1687-1692	WDT	denotes	which
T1439	1693-1696	DT	denotes	the
T1440	1727-1733	NN	denotes	domain
T1441	1697-1699	CD	denotes	78
T1442	1706-1710	NN	denotes	acid
T1443	1699-1700	HYPH	denotes	-
T1444	1700-1705	NN	denotes	amino
T1445	1705-1706	HYPH	denotes	-
T1446	1711-1715	NN	denotes	VP16
T1447	1716-1726	NN	denotes	activation
T1448	1734-1737	VBD	denotes	was
T1449	1744-1746	IN	denotes	to
T1450	1747-1750	DT	denotes	the
T1451	1753-1761	NN	denotes	terminus
T1452	1751-1752	NN	denotes	N
T1453	1752-1753	HYPH	denotes	-
T1454	1762-1764	IN	denotes	of
T1455	1765-1769	JJ	denotes	full
T1456	1770-1776	NN	denotes	length
T1457	1769-1770	HYPH	denotes	-
T1458	1777-1782	NN	denotes	PPARδ
T1459	1782-1784	,	denotes	,
T1460	1784-1789	IN	denotes	under
T1461	1790-1797	NN	denotes	control
T1462	1798-1800	IN	denotes	of
T1463	1801-1804	DT	denotes	the
T1464	1835-1843	NN	denotes	promoter
T1465	1805-1808	CD	denotes	2.2
T1466	1809-1811	NN	denotes	kb
T1467	1808-1809	HYPH	denotes	-
T1468	1812-1817	JJ	denotes	human
T1469	1818-1819	NN	denotes	α
T1470	1820-1828	JJ	denotes	skeletal
T1471	1819-1820	HYPH	denotes	-
T1472	1829-1834	NN	denotes	actin
T1473	1843-1844	.	denotes	.
T1474	1844-2074	sentence	denotes	In agreement with the previous characterization of this promoter (Brennan and Hardeman 1993; Clapham et al. 2000), the VP16-PPARδ transgene was selectively expressed in skeletal muscle, with 10-fold less in the heart (Figure 1C).
T1475	1845-1847	IN	denotes	In
T1476	2001-2010	VBN	denotes	expressed
T1477	1848-1857	NN	denotes	agreement
T1478	1858-1862	IN	denotes	with
T1479	1863-1866	DT	denotes	the
T1480	1876-1892	NN	denotes	characterization
T1481	1867-1875	JJ	denotes	previous
T1482	1893-1895	IN	denotes	of
T1483	1896-1900	DT	denotes	this
T1484	1901-1909	NN	denotes	promoter
T1485	1910-1911	-LRB-	denotes	(
T1486	1911-1918	NNP	denotes	Brennan
T1487	1919-1922	CC	denotes	and
T1488	1923-1931	NNP	denotes	Hardeman
T1489	1932-1936	CD	denotes	1993
T1490	1936-1937	:	denotes	;
T1491	1938-1945	NNP	denotes	Clapham
T1492	1946-1948	FW	denotes	et
T1493	1949-1952	FW	denotes	al.
T1494	1953-1957	CD	denotes	2000
T1495	1957-1958	-RRB-	denotes	)
T1496	1958-1960	,	denotes	,
T1497	1960-1963	DT	denotes	the
T1498	1975-1984	NN	denotes	transgene
T1499	1964-1968	NN	denotes	VP16
T1500	1969-1974	NN	denotes	PPARδ
T1501	1968-1969	HYPH	denotes	-
T1502	1985-1988	VBD	denotes	was
T1503	1989-2000	RB	denotes	selectively
T1504	2011-2013	IN	denotes	in
T1505	2014-2022	JJ	denotes	skeletal
T1506	2023-2029	NN	denotes	muscle
T1507	2029-2031	,	denotes	,
T1508	2031-2035	IN	denotes	with
T1509	2044-2048	JJR	denotes	less
T1510	2036-2038	CD	denotes	10
T1511	2038-2039	HYPH	denotes	-
T1512	2039-2043	RB	denotes	fold
T1513	2049-2051	IN	denotes	in
T1514	2052-2055	DT	denotes	the
T1515	2056-2061	NN	denotes	heart
T1516	2062-2063	-LRB-	denotes	(
T1517	2063-2069	NN	denotes	Figure
T1518	2070-2072	CD	denotes	1C
T1519	2072-2073	-RRB-	denotes	)
T1520	2073-2074	.	denotes	.
T1521	2074-2193	sentence	denotes	Among different types of muscle fibers, the levels of VP16-PPARδ expression appeared to be similar (unpublished data).
T1522	2075-2080	IN	denotes	Among
T1523	2151-2159	VBD	denotes	appeared
T1524	2081-2090	JJ	denotes	different
T1525	2091-2096	NNS	denotes	types
T1526	2097-2099	IN	denotes	of
T1527	2100-2106	NN	denotes	muscle
T1528	2107-2113	NNS	denotes	fibers
T1529	2113-2115	,	denotes	,
T1530	2115-2118	DT	denotes	the
T1531	2119-2125	NNS	denotes	levels
T1532	2126-2128	IN	denotes	of
T1533	2129-2133	NN	denotes	VP16
T1534	2134-2139	NN	denotes	PPARδ
T1535	2133-2134	HYPH	denotes	-
T1536	2140-2150	NN	denotes	expression
T1537	2160-2162	TO	denotes	to
T1538	2163-2165	VB	denotes	be
T1539	2166-2173	JJ	denotes	similar
T1540	2174-2175	-LRB-	denotes	(
T1541	2187-2191	NNS	denotes	data
T1542	2175-2186	JJ	denotes	unpublished
T1543	2191-2192	-RRB-	denotes	)
T1544	2192-2193	.	denotes	.
T1545	2193-2353	sentence	denotes	As shown in Figure 1D for gastrocnemius muscle, VP16-PPARδ fusion protein was produced at a level similar to that of endogenous PPARδ in wild-type littermates.
T1546	2194-2196	IN	denotes	As
T1547	2197-2202	VBN	denotes	shown
T1548	2272-2280	VBN	denotes	produced
T1549	2203-2205	IN	denotes	in
T1550	2206-2212	NN	denotes	Figure
T1551	2213-2215	CD	denotes	1D
T1552	2216-2219	IN	denotes	for
T1553	2220-2233	NN	denotes	gastrocnemius
T1554	2234-2240	NN	denotes	muscle
T1555	2240-2242	,	denotes	,
T1556	2242-2246	NN	denotes	VP16
T1557	2247-2252	NN	denotes	PPARδ
T1558	2246-2247	HYPH	denotes	-
T1559	2260-2267	NN	denotes	protein
T1560	2253-2259	NN	denotes	fusion
T1561	2268-2271	VBD	denotes	was
T1562	2281-2283	IN	denotes	at
T1563	2284-2285	DT	denotes	a
T1564	2286-2291	NN	denotes	level
T1565	2292-2299	JJ	denotes	similar
T1566	2300-2302	IN	denotes	to
T1567	2303-2307	DT	denotes	that
T1568	2308-2310	IN	denotes	of
T1569	2311-2321	JJ	denotes	endogenous
T1570	2322-2327	NN	denotes	PPARδ
T1571	2328-2330	IN	denotes	in
T1572	2331-2335	JJ	denotes	wild
T1573	2336-2340	NN	denotes	type
T1574	2335-2336	HYPH	denotes	-
T1575	2341-2352	NNS	denotes	littermates
T1576	2352-2353	.	denotes	.
T1577	2353-2485	sentence	denotes	Interestingly, the level of endogenous muscle PPARδ protein in the transgenic mice was much higher than in the control littermates.
T1578	2354-2367	RB	denotes	Interestingly
T1579	2437-2440	VBD	denotes	was
T1580	2367-2369	,	denotes	,
T1581	2369-2372	DT	denotes	the
T1582	2373-2378	NN	denotes	level
T1583	2379-2381	IN	denotes	of
T1584	2382-2392	JJ	denotes	endogenous
T1585	2406-2413	NN	denotes	protein
T1586	2393-2399	NN	denotes	muscle
T1587	2400-2405	NN	denotes	PPARδ
T1588	2414-2416	IN	denotes	in
T1589	2417-2420	DT	denotes	the
T1590	2432-2436	NNS	denotes	mice
T1591	2421-2431	JJ	denotes	transgenic
T1592	2441-2445	RB	denotes	much
T1593	2446-2452	JJR	denotes	higher
T1594	2453-2457	IN	denotes	than
T1595	2458-2460	IN	denotes	in
T1596	2461-2464	DT	denotes	the
T1597	2473-2484	NNS	denotes	littermates
T1598	2465-2472	NN	denotes	control
T1599	2484-2485	.	denotes	.
T1600	2485-2665	sentence	denotes	The substantial increase of endogenous PPARδ may have been caused by a switch to type I fiber (see below), which intrinsically expresses higher levels of PPARδ (Figure 1A and 1B).
T1601	2486-2489	DT	denotes	The
T1602	2502-2510	NN	denotes	increase
T1603	2490-2501	JJ	denotes	substantial
T1604	2545-2551	VBN	denotes	caused
T1605	2511-2513	IN	denotes	of
T1606	2514-2524	JJ	denotes	endogenous
T1607	2525-2530	NN	denotes	PPARδ
T1608	2531-2534	MD	denotes	may
T1609	2535-2539	VB	denotes	have
T1610	2540-2544	VBN	denotes	been
T1611	2552-2554	IN	denotes	by
T1612	2555-2556	DT	denotes	a
T1613	2557-2563	NN	denotes	switch
T1614	2564-2566	IN	denotes	to
T1615	2567-2571	NN	denotes	type
T1616	2574-2579	NN	denotes	fiber
T1617	2572-2573	CD	denotes	I
T1618	2580-2581	-LRB-	denotes	(
T1619	2581-2584	VB	denotes	see
T1620	2585-2590	RB	denotes	below
T1621	2590-2591	-RRB-	denotes	)
T1622	2591-2593	,	denotes	,
T1623	2593-2598	WDT	denotes	which
T1624	2613-2622	VBZ	denotes	expresses
T1625	2599-2612	RB	denotes	intrinsically
T1626	2623-2629	JJR	denotes	higher
T1627	2630-2636	NNS	denotes	levels
T1628	2637-2639	IN	denotes	of
T1629	2640-2645	NN	denotes	PPARδ
T1630	2646-2647	-LRB-	denotes	(
T1631	2654-2656	CD	denotes	1A
T1632	2647-2653	NN	denotes	Figure
T1633	2657-2660	CC	denotes	and
T1634	2661-2663	CD	denotes	1B
T1635	2663-2664	-RRB-	denotes	)
T1636	2664-2665	.	denotes	.
T1637	2665-2861	sentence	denotes	Type I muscle can be readily distinguished from type II or mixed muscle by its red color, because of its high concentration of myoglobin, a protein typically expressed in oxidative muscle fibers.
T1638	2666-2670	NN	denotes	Type
T1639	2673-2679	NN	denotes	muscle
T1640	2671-2672	CD	denotes	I
T1641	2695-2708	VBN	denotes	distinguished
T1642	2680-2683	MD	denotes	can
T1643	2684-2686	VB	denotes	be
T1644	2687-2694	RB	denotes	readily
T1645	2709-2713	IN	denotes	from
T1646	2714-2718	NN	denotes	type
T1647	2731-2737	NN	denotes	muscle
T1648	2719-2721	CD	denotes	II
T1649	2722-2724	CC	denotes	or
T1650	2725-2730	VBN	denotes	mixed
T1651	2738-2740	IN	denotes	by
T1652	2741-2744	PRP$	denotes	its
T1653	2749-2754	NN	denotes	color
T1654	2745-2748	JJ	denotes	red
T1655	2754-2756	,	denotes	,
T1656	2756-2763	IN	denotes	because
T1657	2764-2766	IN	denotes	of
T1658	2767-2770	PRP$	denotes	its
T1659	2776-2789	NN	denotes	concentration
T1660	2771-2775	JJ	denotes	high
T1661	2790-2792	IN	denotes	of
T1662	2793-2802	NN	denotes	myoglobin
T1663	2802-2804	,	denotes	,
T1664	2804-2805	DT	denotes	a
T1665	2806-2813	NN	denotes	protein
T1666	2814-2823	RB	denotes	typically
T1667	2824-2833	VBN	denotes	expressed
T1668	2834-2836	IN	denotes	in
T1669	2837-2846	JJ	denotes	oxidative
T1670	2854-2860	NNS	denotes	fibers
T1671	2847-2853	NN	denotes	muscle
T1672	2860-2861	.	denotes	.
T1673	2861-3024	sentence	denotes	We found that muscles in the transgenic mice appeared redder (Figure 2A), which is particularly evident in the mixed type I/II fibers of the hindlimb (Figure 2B).
T1674	2862-2864	PRP	denotes	We
T1675	2865-2870	VBD	denotes	found
T1676	2871-2875	IN	denotes	that
T1677	2907-2915	VBD	denotes	appeared
T1678	2876-2883	NNS	denotes	muscles
T1679	2884-2886	IN	denotes	in
T1680	2887-2890	DT	denotes	the
T1681	2902-2906	NNS	denotes	mice
T1682	2891-2901	JJ	denotes	transgenic
T1683	2916-2922	JJR	denotes	redder
T1684	2923-2924	-LRB-	denotes	(
T1685	2924-2930	NN	denotes	Figure
T1686	2931-2933	CD	denotes	2A
T1687	2933-2934	-RRB-	denotes	)
T1688	2934-2936	,	denotes	,
T1689	2936-2941	WDT	denotes	which
T1690	2942-2944	VBZ	denotes	is
T1691	2945-2957	RB	denotes	particularly
T1692	2958-2965	JJ	denotes	evident
T1693	2966-2968	IN	denotes	in
T1694	2969-2972	DT	denotes	the
T1695	2989-2995	NNS	denotes	fibers
T1696	2973-2978	JJ	denotes	mixed
T1697	2986-2988	CD	denotes	II
T1698	2979-2983	NN	denotes	type
T1699	2984-2985	CD	denotes	I
T1700	2985-2986	HYPH	denotes	/
T1701	2996-2998	IN	denotes	of
T1702	2999-3002	DT	denotes	the
T1703	3003-3011	NN	denotes	hindlimb
T1704	3012-3013	-LRB-	denotes	(
T1705	3013-3019	NN	denotes	Figure
T1706	3020-3022	CD	denotes	2B
T1707	3022-3023	-RRB-	denotes	)
T1708	3023-3024	.	denotes	.
T1709	3024-3119	sentence	denotes	Indeed, metachromatic staining revealed a substantial muscle fiber transformation (Figure 2C).
T1710	3025-3031	RB	denotes	Indeed
T1711	3056-3064	VBD	denotes	revealed
T1712	3031-3033	,	denotes	,
T1713	3033-3046	JJ	denotes	metachromatic
T1714	3047-3055	NN	denotes	staining
T1715	3065-3066	DT	denotes	a
T1716	3092-3106	NN	denotes	transformation
T1717	3067-3078	JJ	denotes	substantial
T1718	3079-3085	NN	denotes	muscle
T1719	3086-3091	NN	denotes	fiber
T1720	3107-3108	-LRB-	denotes	(
T1721	3108-3114	NN	denotes	Figure
T1722	3115-3117	CD	denotes	2C
T1723	3117-3118	-RRB-	denotes	)
T1724	3118-3119	.	denotes	.
T1725	3119-3208	sentence	denotes	In gastrocnemius muscle, we estimated that there was a 2-fold increase of type I fibers.
T1726	3120-3122	IN	denotes	In
T1727	3148-3157	VBD	denotes	estimated
T1728	3123-3136	NN	denotes	gastrocnemius
T1729	3137-3143	NN	denotes	muscle
T1730	3143-3145	,	denotes	,
T1731	3145-3147	PRP	denotes	we
T1732	3158-3162	IN	denotes	that
T1733	3169-3172	VBD	denotes	was
T1734	3163-3168	EX	denotes	there
T1735	3173-3174	DT	denotes	a
T1736	3182-3190	NN	denotes	increase
T1737	3175-3181	JJ	denotes	2-fold
T1738	3191-3193	IN	denotes	of
T1739	3194-3198	NN	denotes	type
T1740	3201-3207	NNS	denotes	fibers
T1741	3199-3200	CD	denotes	I
T1742	3207-3208	.	denotes	.
T1743	3208-3362	sentence	denotes	A diagnostic component of oxidative fibers is their high myoglobin and mitochondrial content, which is supported by the mRNA analysis shown in Figure 3A.
T1744	3209-3210	DT	denotes	A
T1745	3222-3231	NN	denotes	component
T1746	3211-3221	JJ	denotes	diagnostic
T1747	3252-3254	VBZ	denotes	is
T1748	3232-3234	IN	denotes	of
T1749	3235-3244	JJ	denotes	oxidative
T1750	3245-3251	NNS	denotes	fibers
T1751	3255-3260	PRP$	denotes	their
T1752	3294-3301	NN	denotes	content
T1753	3261-3265	JJ	denotes	high
T1754	3266-3275	NN	denotes	myoglobin
T1755	3276-3279	CC	denotes	and
T1756	3280-3293	JJ	denotes	mitochondrial
T1757	3301-3303	,	denotes	,
T1758	3303-3308	WDT	denotes	which
T1759	3312-3321	VBN	denotes	supported
T1760	3309-3311	VBZ	denotes	is
T1761	3322-3324	IN	denotes	by
T1762	3325-3328	DT	denotes	the
T1763	3334-3342	NN	denotes	analysis
T1764	3329-3333	NN	denotes	mRNA
T1765	3343-3348	VBN	denotes	shown
T1766	3349-3351	IN	denotes	in
T1767	3352-3358	NN	denotes	Figure
T1768	3359-3361	CD	denotes	3A
T1769	3361-3362	.	denotes	.
T1770	3362-3571	sentence	denotes	In addition to myoglobin, mitochondrial components for electron transfer (cytochrome c and cytochrome c oxidase [COX] II and IV) and fatty-acid β-oxidation enzymes were elevated (Figure 3A; unpublished data).
T1771	3363-3365	IN	denotes	In
T1772	3532-3540	VBN	denotes	elevated
T1773	3366-3374	NN	denotes	addition
T1774	3375-3377	IN	denotes	to
T1775	3378-3387	NN	denotes	myoglobin
T1776	3387-3389	,	denotes	,
T1777	3389-3402	JJ	denotes	mitochondrial
T1778	3403-3413	NNS	denotes	components
T1779	3414-3417	IN	denotes	for
T1780	3418-3426	NN	denotes	electron
T1781	3427-3435	NN	denotes	transfer
T1782	3436-3437	-LRB-	denotes	(
T1783	3448-3449	NN	denotes	c
T1784	3437-3447	NN	denotes	cytochrome
T1785	3450-3453	CC	denotes	and
T1786	3454-3464	NN	denotes	cytochrome
T1787	3465-3466	NN	denotes	c
T1788	3467-3474	NN	denotes	oxidase
T1789	3475-3476	-LRB-	denotes	[
T1790	3476-3479	NN	denotes	COX
T1791	3479-3480	-RRB-	denotes	]
T1792	3481-3483	CD	denotes	II
T1793	3484-3487	CC	denotes	and
T1794	3488-3490	CD	denotes	IV
T1795	3490-3491	-RRB-	denotes	)
T1796	3492-3495	CC	denotes	and
T1797	3496-3501	JJ	denotes	fatty
T1798	3502-3506	NN	denotes	acid
T1799	3501-3502	HYPH	denotes	-
T1800	3519-3526	NNS	denotes	enzymes
T1801	3507-3508	NN	denotes	β
T1802	3509-3518	NN	denotes	oxidation
T1803	3508-3509	HYPH	denotes	-
T1804	3527-3531	VBD	denotes	were
T1805	3541-3542	-LRB-	denotes	(
T1806	3565-3569	NNS	denotes	data
T1807	3542-3548	NN	denotes	Figure
T1808	3549-3551	CD	denotes	3A
T1809	3551-3552	:	denotes	;
T1810	3553-3564	JJ	denotes	unpublished
T1811	3569-3570	-RRB-	denotes	)
T1812	3570-3571	.	denotes	.
T1813	3571-3810	sentence	denotes	These effects appear to be direct consequences of PPARδ activation, as levels of PGC-1α, a coactivator involved in muscle fiber switch and mitochondrial biogenesis (Wu et al. 1999; Lehman et al. 2000; Lin et al. 2002), remained unchanged.
T1814	3572-3577	DT	denotes	These
T1815	3578-3585	NNS	denotes	effects
T1816	3586-3592	VBP	denotes	appear
T1817	3593-3595	TO	denotes	to
T1818	3596-3598	VB	denotes	be
T1819	3599-3605	JJ	denotes	direct
T1820	3606-3618	NNS	denotes	consequences
T1821	3619-3621	IN	denotes	of
T1822	3622-3627	NN	denotes	PPARδ
T1823	3628-3638	NN	denotes	activation
T1824	3638-3640	,	denotes	,
T1825	3640-3642	IN	denotes	as
T1826	3791-3799	VBD	denotes	remained
T1827	3643-3649	NNS	denotes	levels
T1828	3650-3652	IN	denotes	of
T1829	3653-3656	NN	denotes	PGC
T1830	3656-3657	HYPH	denotes	-
T1831	3657-3659	CD	denotes	1α
T1832	3659-3661	,	denotes	,
T1833	3661-3662	DT	denotes	a
T1834	3663-3674	NN	denotes	coactivator
T1835	3675-3683	VBN	denotes	involved
T1836	3684-3686	IN	denotes	in
T1837	3687-3693	NN	denotes	muscle
T1838	3694-3699	NN	denotes	fiber
T1839	3700-3706	NN	denotes	switch
T1840	3707-3710	CC	denotes	and
T1841	3711-3724	JJ	denotes	mitochondrial
T1842	3725-3735	NN	denotes	biogenesis
T1843	3736-3737	-LRB-	denotes	(
T1844	3737-3739	NNP	denotes	Wu
T1845	3740-3742	FW	denotes	et
T1846	3743-3746	FW	denotes	al.
T1847	3747-3751	CD	denotes	1999
T1848	3751-3752	:	denotes	;
T1849	3753-3759	NNP	denotes	Lehman
T1850	3760-3762	FW	denotes	et
T1851	3763-3766	FW	denotes	al.
T1852	3767-3771	CD	denotes	2000
T1853	3771-3772	:	denotes	;
T1854	3773-3776	NNP	denotes	Lin
T1855	3777-3779	FW	denotes	et
T1856	3780-3783	FW	denotes	al.
T1857	3784-3788	CD	denotes	2002
T1858	3788-3789	-RRB-	denotes	)
T1859	3789-3791	,	denotes	,
T1860	3800-3809	JJ	denotes	unchanged
T1861	3809-3810	.	denotes	.
T1862	3810-3959	sentence	denotes	Southern blot analysis detected a substantially higher copy number of the mitochondrial genome–encoded COXII DNA in the transgenic mice (Figure 3B).
T1863	3811-3819	NNP	denotes	Southern
T1864	3820-3824	NN	denotes	blot
T1865	3825-3833	NN	denotes	analysis
T1866	3834-3842	VBD	denotes	detected
T1867	3843-3844	DT	denotes	a
T1868	3871-3877	NN	denotes	number
T1869	3845-3858	RB	denotes	substantially
T1870	3859-3865	JJR	denotes	higher
T1871	3866-3870	NN	denotes	copy
T1872	3878-3880	IN	denotes	of
T1873	3881-3884	DT	denotes	the
T1874	3920-3923	NN	denotes	DNA
T1875	3885-3898	JJ	denotes	mitochondrial
T1876	3899-3905	NN	denotes	genome
T1877	3906-3913	VBN	denotes	encoded
T1878	3905-3906	HYPH	denotes	–
T1879	3914-3919	NN	denotes	COXII
T1880	3924-3926	IN	denotes	in
T1881	3927-3930	DT	denotes	the
T1882	3942-3946	NNS	denotes	mice
T1883	3931-3941	JJ	denotes	transgenic
T1884	3947-3948	-LRB-	denotes	(
T1885	3948-3954	NN	denotes	Figure
T1886	3955-3957	CD	denotes	3B
T1887	3957-3958	-RRB-	denotes	)
T1888	3958-3959	.	denotes	.
T1889	3959-4060	sentence	denotes	Mitochondrial DNA was increased 2.3-fold in gastrocnemius muscle of the transgenic mice (Figure 3C).
T1890	3960-3973	JJ	denotes	Mitochondrial
T1891	3974-3977	NN	denotes	DNA
T1892	3982-3991	VBN	denotes	increased
T1893	3978-3981	VBD	denotes	was
T1894	3992-3995	CD	denotes	2.3
T1895	3995-3996	HYPH	denotes	-
T1896	3996-4000	RB	denotes	fold
T1897	4001-4003	IN	denotes	in
T1898	4004-4017	NN	denotes	gastrocnemius
T1899	4018-4024	NN	denotes	muscle
T1900	4025-4027	IN	denotes	of
T1901	4028-4031	DT	denotes	the
T1902	4043-4047	NNS	denotes	mice
T1903	4032-4042	JJ	denotes	transgenic
T1904	4048-4049	-LRB-	denotes	(
T1905	4049-4055	NN	denotes	Figure
T1906	4056-4058	CD	denotes	3C
T1907	4058-4059	-RRB-	denotes	)
T1908	4059-4060	.	denotes	.
T1909	4060-4196	sentence	denotes	These results reveal a marked stimulation of mitochondrial biogenesis and further support the idea that there is a muscle fiber switch.
T1910	4061-4066	DT	denotes	These
T1911	4067-4074	NNS	denotes	results
T1912	4075-4081	VBP	denotes	reveal
T1913	4082-4083	DT	denotes	a
T1914	4091-4102	NN	denotes	stimulation
T1915	4084-4090	JJ	denotes	marked
T1916	4103-4105	IN	denotes	of
T1917	4106-4119	JJ	denotes	mitochondrial
T1918	4120-4130	NN	denotes	biogenesis
T1919	4131-4134	CC	denotes	and
T1920	4135-4142	RB	denotes	further
T1921	4143-4150	VBP	denotes	support
T1922	4151-4154	DT	denotes	the
T1923	4155-4159	NN	denotes	idea
T1924	4160-4164	IN	denotes	that
T1925	4171-4173	VBZ	denotes	is
T1926	4165-4170	EX	denotes	there
T1927	4174-4175	DT	denotes	a
T1928	4189-4195	NN	denotes	switch
T1929	4176-4182	NN	denotes	muscle
T1930	4183-4188	NN	denotes	fiber
T1931	4195-4196	.	denotes	.
T1932	4196-4257	sentence	denotes	This conclusion was also confirmed by Western blot analysis.
T1933	4197-4201	DT	denotes	This
T1934	4202-4212	NN	denotes	conclusion
T1935	4222-4231	VBN	denotes	confirmed
T1936	4213-4216	VBD	denotes	was
T1937	4217-4221	RB	denotes	also
T1938	4232-4234	IN	denotes	by
T1939	4235-4242	NNP	denotes	Western
T1940	4243-4247	NN	denotes	blot
T1941	4248-4256	NN	denotes	analysis
T1942	4256-4257	.	denotes	.
T1943	4257-4394	sentence	denotes	As shown in Figure 3D, the characteristic type I fiber proteins, such as myoglobin and cytochrome c and b, were significantly increased.
T1944	4258-4260	IN	denotes	As
T1945	4261-4266	VBN	denotes	shown
T1946	4384-4393	VBN	denotes	increased
T1947	4267-4269	IN	denotes	in
T1948	4270-4276	NN	denotes	Figure
T1949	4277-4279	CD	denotes	3D
T1950	4279-4281	,	denotes	,
T1951	4281-4284	DT	denotes	the
T1952	4313-4321	NN	denotes	proteins
T1953	4285-4299	JJ	denotes	characteristic
T1954	4300-4304	NN	denotes	type
T1955	4307-4312	NN	denotes	fiber
T1956	4305-4306	CD	denotes	I
T1957	4321-4323	,	denotes	,
T1958	4323-4327	JJ	denotes	such
T1959	4328-4330	IN	denotes	as
T1960	4331-4340	NN	denotes	myoglobin
T1961	4341-4344	CC	denotes	and
T1962	4345-4355	NN	denotes	cytochrome
T1963	4362-4363	NN	denotes	b
T1964	4356-4357	NN	denotes	c
T1965	4358-4361	CC	denotes	and
T1966	4363-4365	,	denotes	,
T1967	4365-4369	VBD	denotes	were
T1968	4370-4383	RB	denotes	significantly
T1969	4393-4394	.	denotes	.
T1970	4394-4672	sentence	denotes	More importantly, the specialized contraction protein troponin I (slow) of type I fiber was robustly induced; this was accompanied by a marked reduction of the specialized contraction protein troponin I (fast) of type II fiber, indicating a high degree of fiber transformation.
T1971	4395-4399	RBR	denotes	More
T1972	4400-4411	RB	denotes	importantly
T1973	4496-4503	VBN	denotes	induced
T1974	4411-4413	,	denotes	,
T1975	4413-4416	DT	denotes	the
T1976	4441-4448	NN	denotes	protein
T1977	4417-4428	VBN	denotes	specialized
T1978	4429-4440	NN	denotes	contraction
T1979	4449-4457	NN	denotes	troponin
T1980	4458-4459	CD	denotes	I
T1981	4460-4461	-LRB-	denotes	(
T1982	4461-4465	JJ	denotes	slow
T1983	4465-4466	-RRB-	denotes	)
T1984	4467-4469	IN	denotes	of
T1985	4470-4474	NN	denotes	type
T1986	4477-4482	NN	denotes	fiber
T1987	4475-4476	CD	denotes	I
T1988	4483-4486	VBD	denotes	was
T1989	4487-4495	RB	denotes	robustly
T1990	4514-4525	VBN	denotes	accompanied
T1991	4503-4504	:	denotes	;
T1992	4505-4509	DT	denotes	this
T1993	4510-4513	VBD	denotes	was
T1994	4526-4528	IN	denotes	by
T1995	4529-4530	DT	denotes	a
T1996	4538-4547	NN	denotes	reduction
T1997	4531-4537	JJ	denotes	marked
T1998	4548-4550	IN	denotes	of
T1999	4551-4554	DT	denotes	the
T2000	4579-4586	NN	denotes	protein
T2001	4555-4566	VBN	denotes	specialized
T2002	4567-4578	NN	denotes	contraction
T2003	4587-4595	NN	denotes	troponin
T2004	4596-4597	CD	denotes	I
T2005	4598-4599	-LRB-	denotes	(
T2007	4603-4604	-RRB-	denotes	)
T2008	4605-4607	IN	denotes	of
T2009	4608-4612	NN	denotes	type
T2010	4616-4621	NN	denotes	fiber
T2011	4613-4615	CD	denotes	II
T2012	4621-4623	,	denotes	,
T2013	4623-4633	VBG	denotes	indicating
T2014	4634-4635	DT	denotes	a
T2015	4641-4647	NN	denotes	degree
T2016	4636-4640	JJ	denotes	high
T2017	4648-4650	IN	denotes	of
T2018	4651-4656	NN	denotes	fiber
T2019	4657-4671	NN	denotes	transformation
T2020	4671-4672	.	denotes	.
T2021	4672-4769	sentence	denotes	We next examined whether acute activation of endogenous PPARδ would induce similar target genes.
T2022	4673-4675	PRP	denotes	We
T2023	4681-4689	VBD	denotes	examined
T2024	4676-4680	RB	denotes	next
T2025	4690-4697	IN	denotes	whether
T2026	4741-4747	VB	denotes	induce
T2027	4698-4703	JJ	denotes	acute
T2028	4704-4714	NN	denotes	activation
T2029	4715-4717	IN	denotes	of
T2030	4718-4728	JJ	denotes	endogenous
T2031	4729-4734	NN	denotes	PPARδ
T2032	4735-4740	MD	denotes	would
T2033	4748-4755	JJ	denotes	similar
T2034	4763-4768	NNS	denotes	genes
T2035	4756-4762	NN	denotes	target
T2036	4768-4769	.	denotes	.
T2037	4769-5062	sentence	denotes	In agreement with the chronic effects in the transgenic mice, we found that, after treatment of wild-type C57B6J mice with the PPARδ-specific agonist GW501516 for only 10 d, genes for slow fiber contractile proteins, mitochondrial biogenesis, and β-oxidation were all upregulated (Figure 3E).
T2038	4770-4772	IN	denotes	In
T2039	4835-4840	VBD	denotes	found
T2040	4773-4782	NN	denotes	agreement
T2041	4783-4787	IN	denotes	with
T2042	4788-4791	DT	denotes	the
T2043	4800-4807	NNS	denotes	effects
T2044	4792-4799	JJ	denotes	chronic
T2045	4808-4810	IN	denotes	in
T2046	4811-4814	DT	denotes	the
T2047	4826-4830	NNS	denotes	mice
T2048	4815-4825	JJ	denotes	transgenic
T2049	4830-4832	,	denotes	,
T2050	4832-4834	PRP	denotes	we
T2051	4841-4845	IN	denotes	that
T2052	5038-5049	VBN	denotes	upregulated
T2053	4845-4847	,	denotes	,
T2054	4847-4852	IN	denotes	after
T2055	4853-4862	NN	denotes	treatment
T2056	4863-4865	IN	denotes	of
T2057	4866-4870	JJ	denotes	wild
T2058	4871-4875	NN	denotes	type
T2059	4870-4871	HYPH	denotes	-
T2060	4883-4887	NNS	denotes	mice
T2061	4876-4882	NN	denotes	C57B6J
T2062	4888-4892	IN	denotes	with
T2063	4893-4896	DT	denotes	the
T2064	4920-4928	NN	denotes	GW501516
T2065	4897-4902	NN	denotes	PPARδ
T2066	4903-4911	JJ	denotes	specific
T2067	4902-4903	HYPH	denotes	-
T2068	4912-4919	NN	denotes	agonist
T2069	4929-4932	IN	denotes	for
T2070	4933-4937	RB	denotes	only
T2071	4941-4942	NNS	denotes	d
T2072	4938-4940	CD	denotes	10
T2073	4942-4944	,	denotes	,
T2074	4944-4949	NNS	denotes	genes
T2075	4950-4953	IN	denotes	for
T2076	4954-4958	JJ	denotes	slow
T2077	4959-4964	NN	denotes	fiber
T2078	4977-4985	NN	denotes	proteins
T2079	4965-4976	JJ	denotes	contractile
T2080	4985-4987	,	denotes	,
T2081	4987-5000	JJ	denotes	mitochondrial
T2082	5001-5011	NN	denotes	biogenesis
T2083	5011-5013	,	denotes	,
T2084	5013-5016	CC	denotes	and
T2085	5017-5018	NN	denotes	β
T2086	5019-5028	NN	denotes	oxidation
T2087	5018-5019	HYPH	denotes	-
T2088	5029-5033	VBD	denotes	were
T2089	5034-5037	RB	denotes	all
T2090	5050-5051	-LRB-	denotes	(
T2091	5051-5057	NN	denotes	Figure
T2092	5058-5060	CD	denotes	3E
T2093	5060-5061	-RRB-	denotes	)
T2094	5061-5062	.	denotes	.
T2095	5062-5229	sentence	denotes	This indicates that rapid, systematic, and coordinated changes of muscle fiber properties toward type I can be achieved by activation of the endogenous PPARδ pathway.
T2096	5063-5067	DT	denotes	This
T2097	5068-5077	VBZ	denotes	indicates
T2098	5078-5082	IN	denotes	that
T2099	5174-5182	VBN	denotes	achieved
T2100	5083-5088	JJ	denotes	rapid
T2101	5118-5125	NNS	denotes	changes
T2102	5088-5090	,	denotes	,
T2103	5090-5100	JJ	denotes	systematic
T2104	5100-5102	,	denotes	,
T2105	5102-5105	CC	denotes	and
T2106	5106-5117	VBN	denotes	coordinated
T2107	5126-5128	IN	denotes	of
T2108	5129-5135	NN	denotes	muscle
T2109	5142-5152	NNS	denotes	properties
T2110	5136-5141	NN	denotes	fiber
T2111	5153-5159	IN	denotes	toward
T2112	5160-5164	NN	denotes	type
T2113	5165-5166	CD	denotes	I
T2114	5167-5170	MD	denotes	can
T2115	5171-5173	VB	denotes	be
T2116	5183-5185	IN	denotes	by
T2117	5186-5196	NN	denotes	activation
T2118	5197-5199	IN	denotes	of
T2119	5200-5203	DT	denotes	the
T2120	5221-5228	NN	denotes	pathway
T2121	5204-5214	JJ	denotes	endogenous
T2122	5215-5220	NN	denotes	PPARδ
T2123	5228-5229	.	denotes	.
T4687	651-661	NN	denotes	Expression
T4688	662-664	IN	denotes	of
T4689	665-675	JJ	denotes	Endogenous
T4690	697-706	NN	denotes	Transgene
T4691	676-681	NN	denotes	PPARδ
T4692	682-685	CC	denotes	and
T4693	686-690	NN	denotes	VP16
T4694	691-696	NN	denotes	PPARδ
T4695	690-691	HYPH	denotes	-
T4696	707-709	IN	denotes	in
T4697	710-716	NN	denotes	Muscle
T4698	716-833	sentence	denotes	(A) Pooled RNA isolated from various muscles of five wild-type male C57B6 mice was hybridized with indicated probes.
T4699	717-718	-LRB-	denotes	(
T4700	718-719	LS	denotes	A
T4701	800-810	VBN	denotes	hybridized
T4702	719-720	-RRB-	denotes	)
T4703	721-727	VBN	denotes	Pooled
T4704	728-731	NN	denotes	RNA
T4705	732-740	VBN	denotes	isolated
T4706	741-745	IN	denotes	from
T4707	746-753	JJ	denotes	various
T4708	754-761	NNS	denotes	muscles
T4709	762-764	IN	denotes	of
T4710	765-769	CD	denotes	five
T4711	791-795	NNS	denotes	mice
T4712	770-774	JJ	denotes	wild
T4713	775-779	NN	denotes	type
T4714	774-775	HYPH	denotes	-
T4715	780-784	JJ	denotes	male
T4716	785-790	NN	denotes	C57B6
T4717	796-799	VBD	denotes	was
T4718	811-815	IN	denotes	with
T4719	816-825	VBN	denotes	indicated
T4720	826-832	NNS	denotes	probes
T4721	832-833	.	denotes	.
T4722	833-888	sentence	denotes	EDL, extensor digitorum longus; Gastro, gastrocnemius.
T4723	834-837	NN	denotes	EDL
T4724	837-839	,	denotes	,
T4725	839-847	NN	denotes	extensor
T4726	858-864	NN	denotes	longus
T4727	848-857	NN	denotes	digitorum
T4728	864-865	,	denotes	;
T4729	866-872	NN	denotes	Gastro
T4730	872-874	,	denotes	,
T4731	874-887	NN	denotes	gastrocnemius
T4732	887-888	.	denotes	.
T4733	888-1018	sentence	denotes	(B) Pooled nuclear proteins (15 μg/lane) isolated from muscles of five wild-type male C57B6 were probed with anti-PPARδ antibody.
T4734	889-890	-LRB-	denotes	(
T4735	890-891	LS	denotes	B
T4736	986-992	VBN	denotes	probed
T4737	891-892	-RRB-	denotes	)
T4738	893-899	VBN	denotes	Pooled
T4739	908-916	NN	denotes	proteins
T4740	900-907	JJ	denotes	nuclear
T4741	917-918	-LRB-	denotes	(
T4742	921-923	NNS	denotes	μg
T4743	918-920	CD	denotes	15
T4744	923-924	SYM	denotes	/
T4745	924-928	NN	denotes	lane
T4746	928-929	-RRB-	denotes	)
T4747	930-938	VBN	denotes	isolated
T4748	939-943	IN	denotes	from
T4749	944-951	NNS	denotes	muscles
T4750	952-954	IN	denotes	of
T4751	955-959	CD	denotes	five
T4752	975-980	NN	denotes	C57B6
T4753	960-964	JJ	denotes	wild
T4754	965-969	NN	denotes	type
T4755	964-965	HYPH	denotes	-
T4756	970-974	JJ	denotes	male
T4757	981-985	VBD	denotes	were
T4758	993-997	IN	denotes	with
T4759	998-1008	JJ	denotes	anti-PPARδ
T4760	1009-1017	NN	denotes	antibody
T4761	1017-1018	.	denotes	.
T4762	1018-1076	sentence	denotes	RNA polymerase II (Pol II) is shown as a loading control.
T4763	1019-1022	NN	denotes	RNA
T4764	1023-1033	NN	denotes	polymerase
T4765	1049-1054	VBN	denotes	shown
T4766	1034-1036	CD	denotes	II
T4767	1037-1038	-LRB-	denotes	(
T4768	1038-1041	NN	denotes	Pol
T4769	1042-1044	CD	denotes	II
T4770	1044-1045	-RRB-	denotes	)
T4771	1046-1048	VBZ	denotes	is
T4772	1055-1057	IN	denotes	as
T4773	1058-1059	DT	denotes	a
T4774	1068-1075	NN	denotes	control
T4775	1060-1067	NN	denotes	loading
T4776	1075-1076	.	denotes	.
T4777	1076-1139	sentence	denotes	(C) Expression of the VP16-PPARδ transgene in various tissues.
T4778	1077-1078	-LRB-	denotes	(
T4779	1078-1079	LS	denotes	C
T4780	1081-1091	NN	denotes	Expression
T4781	1079-1080	-RRB-	denotes	)
T4782	1092-1094	IN	denotes	of
T4783	1095-1098	DT	denotes	the
T4784	1110-1119	NN	denotes	transgene
T4785	1099-1103	NN	denotes	VP16
T4786	1104-1109	NN	denotes	PPARδ
T4787	1103-1104	HYPH	denotes	-
T4788	1120-1122	IN	denotes	in
T4789	1123-1130	JJ	denotes	various
T4790	1131-1138	NNS	denotes	tissues
T4791	1138-1139	.	denotes	.
T4792	1139-1214	sentence	denotes	10 μg of total RNA from each tissue was hybridized with a VP16 cDNA probe.
T4793	1140-1142	CD	denotes	10
T4794	1143-1145	NNS	denotes	μg
T4795	1180-1190	VBN	denotes	hybridized
T4796	1146-1148	IN	denotes	of
T4797	1149-1154	JJ	denotes	total
T4798	1155-1158	NN	denotes	RNA
T4799	1159-1163	IN	denotes	from
T4800	1164-1168	DT	denotes	each
T4801	1169-1175	NN	denotes	tissue
T4802	1176-1179	VBD	denotes	was
T4803	1191-1195	IN	denotes	with
T4804	1196-1197	DT	denotes	a
T4805	1208-1213	NN	denotes	probe
T4806	1198-1202	NN	denotes	VP16
T4807	1203-1207	NN	denotes	cDNA
T4808	1213-1214	.	denotes	.
T4809	1214-1250	sentence	denotes	Gastrocnemius muscle was used here.
T4810	1215-1228	NN	denotes	Gastrocnemius
T4811	1229-1235	NN	denotes	muscle
T4812	1240-1244	VBN	denotes	used
T4813	1236-1239	VBD	denotes	was
T4814	1245-1249	RB	denotes	here
T4815	1249-1250	.	denotes	.
T4816	1250-1421	sentence	denotes	(D) Nuclear proteins (15 μg/lane) isolated from gastrocnemius muscle of the transgenic mice (TG) and the wild-type littermates (WT) were probed with indicated antibodies.
T4817	1251-1252	-LRB-	denotes	(
T4818	1252-1253	LS	denotes	D
T4819	1388-1394	VBN	denotes	probed
T4820	1253-1254	-RRB-	denotes	)
T4826	1278-1279	SYM	denotes	/
T4827	1279-1283	NN	denotes	lane
T4828	1283-1284	-RRB-	denotes	)
T4829	1285-1293	VBN	denotes	isolated
T4830	1294-1298	IN	denotes	from
T4831	1299-1312	NN	denotes	gastrocnemius
T4832	1313-1319	NN	denotes	muscle
T4833	1320-1322	IN	denotes	of
T4834	1323-1326	DT	denotes	the
T4835	1338-1342	NNS	denotes	mice
T4836	1327-1337	JJ	denotes	transgenic
T4837	1343-1344	-LRB-	denotes	(
T4838	1344-1346	JJ	denotes	TG
T4839	1346-1347	-RRB-	denotes	)
T4840	1348-1351	CC	denotes	and
T4841	1352-1355	DT	denotes	the
T4842	1366-1377	NNS	denotes	littermates
T4843	1356-1360	JJ	denotes	wild
T4844	1361-1365	NN	denotes	type
T4845	1360-1361	HYPH	denotes	-
T4846	1378-1379	-LRB-	denotes	(
T4847	1379-1381	NN	denotes	WT
T4848	1381-1382	-RRB-	denotes	)
T4849	1383-1387	VBD	denotes	were
T4850	1395-1399	IN	denotes	with
T4851	1400-1409	JJ	denotes	indicated
T4852	1410-1420	NNS	denotes	antibodies
T4853	1420-1421	.	denotes	.
T4854	1421-1523	sentence	denotes	The upper, nonspecific band that cross-reacted with the anti-PPARδ antibody serves a loading control.
T4855	1422-1425	DT	denotes	The
T4856	1445-1449	NN	denotes	band
T4857	1426-1431	JJ	denotes	upper
T4858	1431-1433	,	denotes	,
T4859	1433-1444	JJ	denotes	nonspecific
T4860	1498-1504	VBZ	denotes	serves
T4861	1450-1454	WDT	denotes	that
T4862	1455-1468	VBD	denotes	cross-reacted
T4863	1469-1473	IN	denotes	with
T4864	1474-1477	DT	denotes	the
T4865	1489-1497	NN	denotes	antibody
T4866	1478-1488	JJ	denotes	anti-PPARδ
T4867	1505-1506	DT	denotes	a
T4868	1515-1522	NN	denotes	control
T4869	1507-1514	NN	denotes	loading
T4870	1522-1523	.	denotes	.
T4906	5339-5342	VBP	denotes	are
T4907	5300-5303	CC	denotes	and
T4908	5304-5305	LS	denotes	B
T4909	5305-5306	-RRB-	denotes	)
T4910	5307-5314	NNS	denotes	Muscles
T4911	5315-5317	IN	denotes	in
T4912	5318-5328	JJ	denotes	transgenic
T4913	5329-5333	NNS	denotes	mice
T4914	5334-5335	-LRB-	denotes	(
T4915	5335-5337	JJ	denotes	TG
T4916	5337-5338	-RRB-	denotes	)
T4917	5343-5349	JJR	denotes	redder
T4918	5350-5354	IN	denotes	than
T4919	5355-5360	DT	denotes	those
T4920	5361-5363	IN	denotes	in
T4921	5364-5368	JJ	denotes	wild
T4922	5369-5373	NN	denotes	type
T4923	5368-5369	HYPH	denotes	-
T4924	5374-5378	NNS	denotes	mice
T4925	5379-5380	-LRB-	denotes	(
T4926	5380-5382	NN	denotes	WT
T4927	5382-5383	-RRB-	denotes	)
T4928	5383-5384	.	denotes	.
T4929	5384-5444	sentence	denotes	(C) Metachromatic staining of the type II plantaris muscle.
T4930	5385-5386	-LRB-	denotes	(
T4931	5386-5387	LS	denotes	C
T4932	5403-5411	NN	denotes	staining
T4933	5387-5388	-RRB-	denotes	)
T4934	5389-5402	JJ	denotes	Metachromatic
T4935	5412-5414	IN	denotes	of
T4936	5415-5418	DT	denotes	the
T4937	5437-5443	NN	denotes	muscle
T4938	5419-5423	NN	denotes	type
T4939	5424-5426	CD	denotes	II
T4940	5427-5436	NN	denotes	plantaris
T4941	5443-5444	.	denotes	.
T4942	5444-5481	sentence	denotes	Type I fibers are stained dark blue.
T4943	5445-5449	NN	denotes	Type
T4944	5452-5458	NNS	denotes	fibers
T4945	5450-5451	CD	denotes	I
T4946	5463-5470	VBN	denotes	stained
T4947	5459-5462	VBP	denotes	are
T4948	5471-5475	RB	denotes	dark
T4949	5476-5480	JJ	denotes	blue
T4950	5480-5481	.	denotes	.
T5072	5675-5679	JJ	denotes	wild
T5073	5680-5684	NN	denotes	type
T5074	5679-5680	HYPH	denotes	-
T5075	5685-5686	-LRB-	denotes	(
T5076	5686-5688	NN	denotes	WT
T5077	5688-5689	-RRB-	denotes	)
T5078	5702-5705	VBD	denotes	was
T5079	5713-5717	IN	denotes	with
T5080	5718-5727	VBN	denotes	indicated
T5081	5728-5734	NNS	denotes	probes
T5082	5734-5735	.	denotes	.
T5083	5735-5789	sentence	denotes	The fold increase of induction of each gene is shown.
T5084	5736-5739	DT	denotes	The
T5085	5745-5753	NN	denotes	increase
T5086	5740-5744	JJ	denotes	fold
T5087	5783-5788	VBN	denotes	shown
T5088	5754-5756	IN	denotes	of
T5089	5757-5766	NN	denotes	induction
T5090	5767-5769	IN	denotes	of
T5091	5770-5774	DT	denotes	each
T5092	5775-5779	NN	denotes	gene
T5093	5780-5782	VBZ	denotes	is
T5094	5788-5789	.	denotes	.
T5095	5789-6006	sentence	denotes	(B) Total genomic DNA (10 μg/lane) prepared from gastrocnemius muscle was digested with Nco1 and subjected to Southern analysis with COXII (mitochondrial genome–encoded) and MCIP1 (nuclear genome–encoded) DNA probes.
T5096	5790-5791	-LRB-	denotes	(
T5097	5791-5792	LS	denotes	B
T5098	5864-5872	VBN	denotes	digested
T5099	5792-5793	-RRB-	denotes	)
T5100	5794-5799	JJ	denotes	Total
T5101	5808-5811	NN	denotes	DNA
T5102	5800-5807	JJ	denotes	genomic
T5103	5812-5813	-LRB-	denotes	(
T5111	5839-5852	NN	denotes	gastrocnemius
T5112	5853-5859	NN	denotes	muscle
T5113	5860-5863	VBD	denotes	was
T5114	5873-5877	IN	denotes	with
T5115	5878-5882	NN	denotes	Nco1
T5116	5883-5886	CC	denotes	and
T5117	5887-5896	VBN	denotes	subjected
T5118	5897-5899	IN	denotes	to
T5119	5900-5908	NNP	denotes	Southern
T5120	5909-5917	NN	denotes	analysis
T5121	5918-5922	IN	denotes	with
T5122	5923-5928	NN	denotes	COXII
T5123	5999-6005	NNS	denotes	probes
T5124	5929-5930	-LRB-	denotes	(
T5125	5951-5958	VBN	denotes	encoded
T5126	5930-5943	JJ	denotes	mitochondrial
T5127	5944-5950	NN	denotes	genome
T5128	5950-5951	HYPH	denotes	–
T5129	5958-5959	-RRB-	denotes	)
T5130	5960-5963	CC	denotes	and
T5131	5964-5969	NN	denotes	MCIP1
T5132	5970-5971	-LRB-	denotes	(
T5133	5986-5993	VBN	denotes	encoded
T5134	5971-5978	JJ	denotes	nuclear
T5135	5979-5985	NN	denotes	genome
T5136	5985-5986	HYPH	denotes	–
T5137	5993-5994	-RRB-	denotes	)
T5138	5995-5998	NN	denotes	DNA
T5139	6005-6006	.	denotes	.
T5140	6006-6114	sentence	denotes	(C) Equal amounts of gastrocnemius muscle were collected from both transgenic mice and control littermates.
T5141	6007-6008	-LRB-	denotes	(
T5142	6008-6009	LS	denotes	C
T5143	6054-6063	VBN	denotes	collected
T5144	6009-6010	-RRB-	denotes	)
T5145	6011-6016	JJ	denotes	Equal
T5146	6017-6024	NNS	denotes	amounts
T5147	6025-6027	IN	denotes	of
T5148	6028-6041	NN	denotes	gastrocnemius
T5149	6042-6048	NN	denotes	muscle
T5150	6049-6053	VBD	denotes	were
T5151	6064-6068	IN	denotes	from
T5152	6069-6073	CC	denotes	both
T5153	6085-6089	NNS	denotes	mice
T5154	6074-6084	JJ	denotes	transgenic
T5155	6090-6093	CC	denotes	and
T5156	6094-6101	NN	denotes	control
T5157	6102-6113	NNS	denotes	littermates
T5158	6113-6114	.	denotes	.
T5159	6114-6184	sentence	denotes	Total mitochondrial DNA was isolated and separated on 1% agarose gel.
T5160	6115-6120	JJ	denotes	Total
T5161	6135-6138	NN	denotes	DNA
T5162	6121-6134	JJ	denotes	mitochondrial
T5163	6143-6151	VBN	denotes	isolated
T5164	6139-6142	VBD	denotes	was
T5165	6152-6155	CC	denotes	and
T5166	6156-6165	VBN	denotes	separated
T5167	6166-6168	IN	denotes	on
T5168	6169-6170	CD	denotes	1
T5169	6170-6171	NN	denotes	%
T5170	6180-6183	NN	denotes	gel
T5171	6172-6179	NN	denotes	agarose
T5172	6183-6184	.	denotes	.
T5173	6184-6275	sentence	denotes	The relative abundance of mitochondrial DNA in transgenic and wild-type mice is presented.
T5174	6185-6188	DT	denotes	The
T5175	6198-6207	NN	denotes	abundance
T5176	6189-6197	JJ	denotes	relative
T5177	6265-6274	VBN	denotes	presented
T5178	6208-6210	IN	denotes	of
T5179	6211-6224	JJ	denotes	mitochondrial
T5180	6225-6228	NN	denotes	DNA
T5181	6229-6231	IN	denotes	in
T5182	6232-6242	JJ	denotes	transgenic
T5183	6257-6261	NNS	denotes	mice
T5184	6243-6246	CC	denotes	and
T5185	6247-6251	JJ	denotes	wild
T5186	6252-6256	NN	denotes	type
T5187	6251-6252	HYPH	denotes	-
T5188	6262-6264	VBZ	denotes	is
T5189	6274-6275	.	denotes	.
T5190	6275-6355	sentence	denotes	(D) Western blot analysis of muscle fiber markers and mitochondrial components.
T5191	6276-6277	-LRB-	denotes	(
T5192	6277-6278	LS	denotes	D
T5193	6293-6301	NN	denotes	analysis
T5194	6278-6279	-RRB-	denotes	)
T5195	6280-6287	NNP	denotes	Western
T5196	6288-6292	NN	denotes	blot
T5197	6302-6304	IN	denotes	of
T5198	6305-6311	NN	denotes	muscle
T5199	6312-6317	NN	denotes	fiber
T5200	6318-6325	NNS	denotes	markers
T5201	6326-6329	CC	denotes	and
T5202	6330-6343	JJ	denotes	mitochondrial
T5203	6344-6354	NNS	denotes	components
T5204	6354-6355	.	denotes	.
T5205	6355-6427	sentence	denotes	Each lane was loaded with 80 μg of total gastrocnemius muscle extracts.
T5206	6356-6360	DT	denotes	Each
T5207	6361-6365	NN	denotes	lane
T5208	6370-6376	VBN	denotes	loaded
T5209	6366-6369	VBD	denotes	was
T5210	6377-6381	IN	denotes	with
T5211	6382-6384	CD	denotes	80
T5212	6385-6387	NNS	denotes	μg
T5213	6388-6390	IN	denotes	of
T5214	6391-6396	JJ	denotes	total
T5215	6418-6426	NNS	denotes	extracts
T5216	6397-6410	NN	denotes	gastrocnemius
T5217	6411-6417	NN	denotes	muscle
T5218	6426-6427	.	denotes	.
T5219	6427-6514	sentence	denotes	(E) Wild-type C57B6 mice were treated with vehicle or PPARδ agonist GW501516 for 10 d.
T5220	6428-6429	-LRB-	denotes	(
T5221	6429-6430	LS	denotes	E
T5222	6458-6465	VBN	denotes	treated
T5223	6430-6431	-RRB-	denotes	)
T5224	6432-6436	JJ	denotes	Wild
T5225	6437-6441	NN	denotes	type
T5226	6436-6437	HYPH	denotes	-
T5227	6448-6452	NNS	denotes	mice
T5228	6442-6447	NN	denotes	C57B6
T5229	6453-6457	VBD	denotes	were
T5230	6466-6470	IN	denotes	with
T5231	6471-6478	NN	denotes	vehicle
T5232	6479-6481	CC	denotes	or
T5233	6482-6487	NN	denotes	PPARδ
T5234	6488-6495	NN	denotes	agonist
T5235	6496-6504	NN	denotes	GW501516
T5236	6505-6508	IN	denotes	for
T5237	6509-6511	CD	denotes	10
T5238	6512-6513	NN	denotes	d
T5239	6513-6514	.	denotes	.
T5240	6514-6610	sentence	denotes	Total RNA (10 μg/lane) prepared from the gastrocnemius muscle was probed with indicated probes.
T5241	6515-6520	JJ	denotes	Total
T5242	6521-6524	NN	denotes	RNA
T5243	6581-6587	VBN	denotes	probed
T5244	6525-6526	-LRB-	denotes	(
T5245	6529-6531	NNS	denotes	μg
T5246	6526-6528	CD	denotes	10
T5247	6531-6532	SYM	denotes	/
T5248	6532-6536	NN	denotes	lane
T5249	6536-6537	-RRB-	denotes	)
T5250	6538-6546	VBN	denotes	prepared
T5251	6547-6551	IN	denotes	from
T5252	6552-6555	DT	denotes	the
T5253	6570-6576	NN	denotes	muscle
T5254	6556-6569	NN	denotes	gastrocnemius
T5255	6577-6580	VBD	denotes	was
T5256	6588-6592	IN	denotes	with
T5257	6593-6602	VBN	denotes	indicated
T5258	6603-6609	NNS	denotes	probes
T5259	6609-6610	.	denotes	.
T4902	5281-5291	JJ	denotes	Transgenic
T4903	5296-5384	sentence	denotes	(A and B) Muscles in transgenic mice (TG) are redder than those in wild-type mice (WT).
T4904	5297-5298	-LRB-	denotes	(
T4905	5298-5299	LS	denotes	A
T4894	5240-5249	VBN	denotes	Increased
T4895	5267-5273	NNS	denotes	Fibers
T4896	5250-5259	JJ	denotes	Oxidative
T4897	5260-5264	NN	denotes	Type
T4898	5265-5266	CD	denotes	I
T4899	5274-5276	IN	denotes	in
T4900	5277-5280	DT	denotes	the
T4901	5292-5296	NNS	denotes	Mice
T4821	1255-1262	JJ	denotes	Nuclear
T4822	1263-1271	NN	denotes	proteins
T4823	1272-1273	-LRB-	denotes	(
T4824	1276-1278	NNS	denotes	μg
T4825	1273-1275	CD	denotes	15
T5034	5492-5502	NN	denotes	Activation
T5035	5512-5519	VBZ	denotes	Induces
T5036	5503-5505	IN	denotes	of
T5037	5506-5511	NN	denotes	PPARδ
T5038	5520-5525	NNS	denotes	Genes
T5039	5526-5533	JJ	denotes	Typical
T5040	5534-5537	IN	denotes	for
T5041	5538-5542	NN	denotes	Type
T5042	5545-5551	NNS	denotes	Fibers
T5043	5543-5544	CD	denotes	I
T5044	5552-5555	CC	denotes	and
T5045	5556-5564	VBZ	denotes	Promotes
T5046	5565-5578	JJ	denotes	Mitochondrial
T5047	5579-5589	NN	denotes	Biogenesis
T5048	5589-5735	sentence	denotes	(A) Total RNA (10 μg/lane) prepared from gastrocnemius muscle of transgenic (TG) and wild-type (WT) littermates was probed with indicated probes.
T5049	5590-5591	-LRB-	denotes	(
T5050	5591-5592	LS	denotes	A
T5051	5706-5712	VBN	denotes	probed
T5052	5592-5593	-RRB-	denotes	)
T5053	5594-5599	JJ	denotes	Total
T5054	5600-5603	NN	denotes	RNA
T5055	5604-5605	-LRB-	denotes	(
T5056	5608-5610	NNS	denotes	μg
T5057	5605-5607	CD	denotes	10
T5058	5610-5611	SYM	denotes	/
T5059	5611-5615	NN	denotes	lane
T5060	5615-5616	-RRB-	denotes	)
T5061	5617-5625	VBN	denotes	prepared
T5062	5626-5630	IN	denotes	from
T5063	5631-5644	NN	denotes	gastrocnemius
T5064	5645-5651	NN	denotes	muscle
T5065	5652-5654	IN	denotes	of
T5066	5655-5665	JJ	denotes	transgenic
T5067	5690-5701	NNS	denotes	littermates
T5068	5666-5667	-LRB-	denotes	(
T5069	5667-5669	JJ	denotes	TG
T5070	5669-5670	-RRB-	denotes	)
T5071	5671-5674	CC	denotes	and
T5104	5816-5818	NNS	denotes	μg
T5105	5813-5815	CD	denotes	10
T5106	5818-5819	SYM	denotes	/
T5107	5819-5823	NN	denotes	lane
T5108	5823-5824	-RRB-	denotes	)
T5109	5825-5833	VBN	denotes	prepared
T5110	5834-5838	IN	denotes	from
R723	T1279	T1280	nsubj	Activation,Leads
R724	T1281	T1279	prep	of,Activation
R725	T1282	T1281	pobj	PPARδ,of
R726	T1283	T1280	prep	to,Leads
R727	T1284	T1285	compound	Muscle,Fiber
R728	T1285	T1286	compound	Fiber,Transformation
R729	T1286	T1283	pobj	Transformation,to
R730	T1288	T1289	det	A,role
R731	T1289	T1290	nsubjpass	role,suggested
R732	T1291	T1289	prep	of,role
R733	T1292	T1291	pobj	PPARδ,of
R734	T1293	T1289	prep	in,role
R735	T1294	T1295	compound	muscle,fiber
R736	T1295	T1293	pobj	fiber,in
R737	T1296	T1290	auxpass	was,suggested
R738	T1297	T1290	agent	by,suggested
R739	T1298	T1299	poss	its,expression
R740	T1299	T1297	pobj	expression,by
R741	T1300	T1299	amod	enhanced,expression
R742	T1301	T1299	punct	—,expression
R743	T1302	T1299	prep	at,expression
R744	T1303	T1302	pobj	levels,at
R745	T1304	T1305	npadvmod	10,greater
R746	T1305	T1303	amod	greater,levels
R747	T1306	T1304	punct	-,10
R748	T1307	T1304	advmod	fold,10
R749	T1308	T1304	cc	and,10
R750	T1309	T1304	conj	50,10
R751	T1310	T1309	punct	-,50
R752	T1311	T1309	advmod	fold,50
R753	T1312	T1305	prep	than,greater
R754	T1313	T1314	nmod	PPARα,isoforms
R755	T1314	T1312	pobj	isoforms,than
R756	T1315	T1313	cc	and,PPARα
R757	T1316	T1313	punct	γ,PPARα
R758	T1317	T1290	punct	", ",suggested
R759	T1318	T1290	advmod	respectively,suggested
R760	T1319	T1320	punct	(,data
R761	T1320	T1290	parataxis	data,suggested
R762	T1321	T1320	amod	unpublished,data
R763	T1322	T1320	punct	),data
R764	T1323	T1290	punct	.,suggested
R765	T1325	T1326	det	An,examination
R766	T1326	T1327	nsubj	examination,reveals
R767	T1327	T1334	ccomp	reveals,resembles
R768	T1328	T1326	prep	of,examination
R769	T1329	T1328	pobj	PPARδ,of
R770	T1330	T1326	prep	in,examination
R771	T1331	T1332	amod	different,fibers
R772	T1332	T1330	pobj	fibers,in
R773	T1333	T1332	compound	muscle,fibers
R774	T1335	T1336	det	a,level
R775	T1336	T1327	dobj	level,reveals
R776	T1337	T1338	advmod	significantly,higher
R777	T1338	T1336	amod	higher,level
R778	T1339	T1327	prep	in,reveals
R779	T1340	T1341	nmod	type,muscle
R780	T1341	T1339	pobj	muscle,in
R781	T1342	T1340	nummod	I,type
R782	T1343	T1344	punct	(,soleus
R783	T1344	T1341	parataxis	soleus,muscle
R784	T1345	T1344	punct	),soleus
R785	T1346	T1327	advcl	relative,reveals
R786	T1347	T1346	prep	to,relative
R787	T1348	T1349	npadvmod	type,rich
R788	T1349	T1352	amod	rich,muscle
R789	T1350	T1348	nummod	II,type
R790	T1351	T1349	punct	–,rich
R791	T1352	T1347	pobj	muscle,to
R792	T1353	T1354	punct	(,longus
R793	T1354	T1352	parataxis	longus,muscle
R794	T1355	T1354	compound	extensor,longus
R795	T1356	T1354	compound	digitorum,longus
R796	T1357	T1354	punct	),longus
R797	T1358	T1352	cc	or,muscle
R798	T1359	T1360	nmod	type,muscle
R799	T1360	T1352	conj	muscle,muscle
R800	T1361	T1359	nummod	I,type
R801	T1362	T1359	cc	and,type
R802	T1363	T1359	conj	type,type
R803	T1364	T1363	nummod	II,type
R804	T1365	T1360	amod	mixed,muscle
R805	T1366	T1367	punct	(,gastrocnemius
R806	T1367	T1360	parataxis	gastrocnemius,muscle
R807	T1368	T1367	punct	),gastrocnemius
R808	T1369	T1370	punct	(,Figure
R809	T1370	T1327	parataxis	Figure,reveals
R810	T1371	T1370	nummod	1A,Figure
R811	T1372	T1370	punct	),Figure
R812	T1373	T1334	punct	;,resembles
R813	T1374	T1375	det	this,pattern
R814	T1375	T1334	nsubj	pattern,resembles
R815	T1376	T1375	compound	expression,pattern
R816	T1377	T1334	advmod	closely,resembles
R817	T1378	T1334	dobj	that,resembles
R818	T1379	T1378	prep	of,that
R819	T1380	T1379	pobj	PGC,of
R820	T1381	T1380	punct	-,PGC
R821	T1382	T1380	nummod	1α,PGC
R822	T1383	T1384	punct	(,Lin
R823	T1384	T1334	meta	Lin,resembles
R824	T1385	T1384	nmod	et,Lin
R825	T1386	T1384	nmod	al.,Lin
R826	T1387	T1384	nummod	2002,Lin
R827	T1388	T1384	punct	),Lin
R828	T1389	T1334	punct	.,resembles
R829	T1391	T1392	det	A,pattern
R830	T1392	T1394	nsubjpass	pattern,found
R831	T1393	T1392	amod	similar,pattern
R832	T1395	T1396	cc	but,with
R833	T1396	T1392	nmod	with,pattern
R834	T1397	T1398	advmod	more,pronounced
R835	T1398	T1399	amod	pronounced,differences
R836	T1399	T1396	pobj	differences,with
R837	T1400	T1394	auxpass	was,found
R838	T1401	T1394	prep	at,found
R839	T1402	T1403	det	the,level
R840	T1403	T1401	pobj	level,at
R841	T1404	T1403	compound	protein,level
R842	T1405	T1406	punct	(,Figure
R843	T1406	T1394	parataxis	Figure,found
R844	T1407	T1406	nummod	1B,Figure
R845	T1408	T1406	punct	),Figure
R846	T1409	T1394	punct	.,found
R847	T1411	T1412	aux	To,assess
R848	T1412	T1414	advcl	assess,generated
R849	T1413	T1412	advmod	directly,assess
R850	T1415	T1416	det	the,role
R851	T1416	T1412	dobj	role,assess
R852	T1417	T1416	prep	of,role
R853	T1418	T1417	pobj	activation,of
R854	T1419	T1418	prep	of,activation
R855	T1420	T1419	pobj	PPARδ,of
R856	T1421	T1416	prep	in,role
R857	T1422	T1421	pobj	control,in
R858	T1423	T1422	prep	of,control
R859	T1424	T1425	compound	muscle,fiber
R860	T1425	T1426	compound	fiber,plasticity
R861	T1426	T1423	pobj	plasticity,of
R862	T1427	T1426	cc	and,plasticity
R863	T1428	T1429	amod	mitochondrial,biogenesis
R864	T1429	T1426	conj	biogenesis,plasticity
R865	T1430	T1414	punct	", ",generated
R866	T1431	T1414	nsubj	we,generated
R867	T1432	T1414	dobj	mice,generated
R868	T1433	T1432	acl	expressing,mice
R869	T1434	T1435	det	a,transgene
R870	T1435	T1433	dobj	transgene,expressing
R871	T1436	T1437	prep	in,fused
R872	T1437	T1435	relcl	fused,transgene
R873	T1438	T1436	pobj	which,in
R874	T1439	T1440	det	the,domain
R875	T1440	T1437	nsubjpass	domain,fused
R876	T1441	T1442	nummod	78,acid
R877	T1442	T1440	compound	acid,domain
R878	T1443	T1442	punct	-,acid
R879	T1444	T1442	compound	amino,acid
R880	T1445	T1442	punct	-,acid
R881	T1446	T1447	compound	VP16,activation
R882	T1447	T1440	compound	activation,domain
R883	T1448	T1437	auxpass	was,fused
R884	T1449	T1437	prep	to,fused
R885	T1450	T1451	det	the,terminus
R886	T1451	T1449	pobj	terminus,to
R887	T1452	T1451	compound	N,terminus
R888	T1453	T1451	punct	-,terminus
R889	T1454	T1451	prep	of,terminus
R890	T1455	T1456	amod	full,length
R891	T1456	T1458	compound	length,PPARδ
R892	T1457	T1456	punct	-,length
R893	T1458	T1454	pobj	PPARδ,of
R894	T1459	T1437	punct	", ",fused
R895	T1460	T1437	prep	under,fused
R896	T1461	T1460	pobj	control,under
R897	T1462	T1461	prep	of,control
R898	T1463	T1464	det	the,promoter
R899	T1464	T1462	pobj	promoter,of
R900	T1465	T1466	nummod	2.2,kb
R901	T1466	T1464	nmod	kb,promoter
R902	T1467	T1466	punct	-,kb
R903	T1468	T1464	amod	human,promoter
R904	T1469	T1470	npadvmod	α,skeletal
R905	T1470	T1464	amod	skeletal,promoter
R906	T1471	T1470	punct	-,skeletal
R907	T1472	T1464	compound	actin,promoter
R908	T1473	T1414	punct	.,generated
R909	T1475	T1476	prep	In,expressed
R910	T1477	T1475	pobj	agreement,In
R911	T1478	T1477	prep	with,agreement
R912	T1479	T1480	det	the,characterization
R913	T1480	T1478	pobj	characterization,with
R914	T1481	T1480	amod	previous,characterization
R915	T1482	T1480	prep	of,characterization
R916	T1483	T1484	det	this,promoter
R917	T1484	T1482	pobj	promoter,of
R918	T1485	T1486	punct	(,Brennan
R919	T1486	T1480	meta	Brennan,characterization
R920	T1487	T1486	cc	and,Brennan
R921	T1488	T1486	conj	Hardeman,Brennan
R922	T1489	T1488	nummod	1993,Hardeman
R923	T1490	T1488	punct	;,Hardeman
R924	T1491	T1488	conj	Clapham,Hardeman
R925	T1492	T1491	nmod	et,Clapham
R926	T1493	T1491	nmod	al.,Clapham
R927	T1494	T1491	nummod	2000,Clapham
R928	T1495	T1491	punct	),Clapham
R929	T1496	T1476	punct	", ",expressed
R930	T1497	T1498	det	the,transgene
R931	T1498	T1476	nsubjpass	transgene,expressed
R932	T1499	T1500	compound	VP16,PPARδ
R933	T1500	T1498	compound	PPARδ,transgene
R934	T1501	T1500	punct	-,PPARδ
R935	T1502	T1476	auxpass	was,expressed
R936	T1503	T1476	advmod	selectively,expressed
R937	T1504	T1476	prep	in,expressed
R938	T1505	T1506	amod	skeletal,muscle
R939	T1506	T1504	pobj	muscle,in
R940	T1507	T1476	punct	", ",expressed
R941	T1508	T1509	mark	with,less
R942	T1509	T1476	advcl	less,expressed
R943	T1510	T1509	nummod	10,less
R944	T1511	T1510	punct	-,10
R945	T1512	T1510	advmod	fold,10
R946	T1513	T1509	prep	in,less
R947	T1514	T1515	det	the,heart
R948	T1515	T1513	pobj	heart,in
R949	T1516	T1517	punct	(,Figure
R950	T1517	T1476	parataxis	Figure,expressed
R951	T1518	T1517	nummod	1C,Figure
R952	T1519	T1517	punct	),Figure
R953	T1520	T1476	punct	.,expressed
R954	T1522	T1523	prep	Among,appeared
R955	T1524	T1525	amod	different,types
R956	T1525	T1522	pobj	types,Among
R957	T1526	T1525	prep	of,types
R958	T1527	T1528	compound	muscle,fibers
R959	T1528	T1526	pobj	fibers,of
R960	T1529	T1523	punct	", ",appeared
R961	T1530	T1531	det	the,levels
R962	T1531	T1523	nsubj	levels,appeared
R963	T1532	T1531	prep	of,levels
R964	T1533	T1534	compound	VP16,PPARδ
R965	T1534	T1536	compound	PPARδ,expression
R966	T1535	T1534	punct	-,PPARδ
R967	T1536	T1532	pobj	expression,of
R968	T1537	T1538	aux	to,be
R969	T1538	T1523	xcomp	be,appeared
R970	T1539	T1538	acomp	similar,be
R971	T1540	T1541	punct	(,data
R972	T1541	T1538	parataxis	data,be
R973	T1542	T1541	amod	unpublished,data
R974	T1543	T1541	punct	),data
R975	T1544	T1523	punct	.,appeared
R976	T1546	T1547	mark	As,shown
R977	T1547	T1548	advcl	shown,produced
R978	T1549	T1547	prep	in,shown
R979	T1550	T1549	pobj	Figure,in
R980	T1551	T1550	nummod	1D,Figure
R981	T1552	T1547	prep	for,shown
R982	T1553	T1554	compound	gastrocnemius,muscle
R983	T1554	T1552	pobj	muscle,for
R984	T1555	T1548	punct	", ",produced
R985	T1556	T1557	compound	VP16,PPARδ
R986	T1557	T1559	compound	PPARδ,protein
R987	T1558	T1557	punct	-,PPARδ
R988	T1559	T1548	nsubjpass	protein,produced
R989	T1560	T1559	compound	fusion,protein
R990	T1561	T1548	auxpass	was,produced
R991	T1562	T1548	prep	at,produced
R992	T1563	T1564	det	a,level
R993	T1564	T1562	pobj	level,at
R994	T1565	T1564	amod	similar,level
R995	T1566	T1565	prep	to,similar
R996	T1567	T1566	pobj	that,to
R997	T1568	T1567	prep	of,that
R998	T1569	T1570	amod	endogenous,PPARδ
R999	T1570	T1568	pobj	PPARδ,of
R1000	T1571	T1548	prep	in,produced
R1001	T1572	T1573	amod	wild,type
R1002	T1573	T1575	compound	type,littermates
R1003	T1574	T1573	punct	-,type
R1004	T1575	T1571	pobj	littermates,in
R1005	T1576	T1548	punct	.,produced
R1006	T1578	T1579	advmod	Interestingly,was
R1007	T1580	T1579	punct	", ",was
R1008	T1581	T1582	det	the,level
R1009	T1582	T1579	nsubj	level,was
R1010	T1583	T1582	prep	of,level
R1011	T1584	T1585	amod	endogenous,protein
R1012	T1585	T1583	pobj	protein,of
R1013	T1586	T1585	compound	muscle,protein
R1014	T1587	T1585	compound	PPARδ,protein
R1015	T1588	T1582	prep	in,level
R1016	T1589	T1590	det	the,mice
R1017	T1590	T1588	pobj	mice,in
R1018	T1591	T1590	amod	transgenic,mice
R1019	T1592	T1593	advmod	much,higher
R1020	T1593	T1579	acomp	higher,was
R1021	T1594	T1593	prep	than,higher
R1022	T1595	T1594	prep	in,than
R1023	T1596	T1597	det	the,littermates
R1024	T1597	T1595	pobj	littermates,in
R1025	T1598	T1597	compound	control,littermates
R1026	T1599	T1579	punct	.,was
R1027	T1601	T1602	det	The,increase
R1028	T1602	T1604	nsubjpass	increase,caused
R1029	T1603	T1602	amod	substantial,increase
R1030	T1605	T1602	prep	of,increase
R1031	T1606	T1607	amod	endogenous,PPARδ
R1032	T1607	T1605	pobj	PPARδ,of
R1033	T1608	T1604	aux	may,caused
R1034	T1609	T1604	aux	have,caused
R1035	T1610	T1604	auxpass	been,caused
R1036	T1611	T1604	agent	by,caused
R1037	T1612	T1613	det	a,switch
R1038	T1613	T1611	pobj	switch,by
R1039	T1614	T1613	prep	to,switch
R1040	T1615	T1616	nmod	type,fiber
R1041	T1616	T1614	pobj	fiber,to
R1042	T1617	T1615	nummod	I,type
R1043	T1618	T1619	punct	(,see
R1044	T1619	T1616	parataxis	see,fiber
R1045	T1620	T1619	advmod	below,see
R1046	T1621	T1619	punct	),see
R1047	T1622	T1616	punct	", ",fiber
R1048	T1623	T1624	dep	which,expresses
R1049	T1624	T1616	relcl	expresses,fiber
R1050	T1625	T1624	advmod	intrinsically,expresses
R1051	T1626	T1627	amod	higher,levels
R1052	T1627	T1624	dobj	levels,expresses
R1053	T1628	T1627	prep	of,levels
R1054	T1629	T1628	pobj	PPARδ,of
R1055	T1630	T1631	punct	(,1A
R1056	T1631	T1624	parataxis	1A,expresses
R1057	T1632	T1631	nmod	Figure,1A
R1058	T1633	T1631	cc	and,1A
R1059	T1634	T1631	conj	1B,1A
R1060	T1635	T1631	punct	),1A
R1061	T1636	T1604	punct	.,caused
R1062	T1638	T1639	nmod	Type,muscle
R1063	T1639	T1641	nsubjpass	muscle,distinguished
R1064	T1640	T1638	nummod	I,Type
R1065	T1642	T1641	aux	can,distinguished
R1066	T1643	T1641	auxpass	be,distinguished
R1067	T1644	T1641	advmod	readily,distinguished
R1068	T1645	T1641	prep	from,distinguished
R1069	T1646	T1647	nmod	type,muscle
R1070	T1647	T1645	pobj	muscle,from
R1071	T1648	T1646	nummod	II,type
R1072	T1649	T1646	cc	or,type
R1073	T1650	T1646	conj	mixed,type
R1074	T1651	T1641	prep	by,distinguished
R1075	T1652	T1653	poss	its,color
R1076	T1653	T1651	pobj	color,by
R1077	T1654	T1653	amod	red,color
R1078	T1655	T1641	punct	", ",distinguished
R1079	T1656	T1641	prep	because,distinguished
R1080	T1657	T1656	prep	of,because
R1081	T1658	T1659	poss	its,concentration
R1082	T1659	T1657	pobj	concentration,of
R1083	T1660	T1659	amod	high,concentration
R1084	T1661	T1659	prep	of,concentration
R1085	T1662	T1661	pobj	myoglobin,of
R1086	T1663	T1662	punct	", ",myoglobin
R1087	T1664	T1665	det	a,protein
R1088	T1665	T1662	appos	protein,myoglobin
R1089	T1666	T1667	advmod	typically,expressed
R1090	T1667	T1665	acl	expressed,protein
R1091	T1668	T1667	prep	in,expressed
R1092	T1669	T1670	amod	oxidative,fibers
R1093	T1670	T1668	pobj	fibers,in
R1094	T1671	T1670	compound	muscle,fibers
R1095	T1672	T1641	punct	.,distinguished
R1096	T1674	T1675	nsubj	We,found
R1097	T1676	T1677	mark	that,appeared
R1098	T1677	T1675	ccomp	appeared,found
R1099	T1678	T1677	nsubj	muscles,appeared
R1100	T1679	T1678	prep	in,muscles
R1101	T1680	T1681	det	the,mice
R1102	T1681	T1679	pobj	mice,in
R1103	T1682	T1681	amod	transgenic,mice
R1104	T1683	T1677	oprd	redder,appeared
R1105	T1684	T1685	punct	(,Figure
R1106	T1685	T1677	parataxis	Figure,appeared
R1107	T1686	T1685	nummod	2A,Figure
R1108	T1687	T1685	punct	),Figure
R1109	T1688	T1677	punct	", ",appeared
R1110	T1689	T1690	dep	which,is
R1111	T1690	T1677	advcl	is,appeared
R1112	T1691	T1692	advmod	particularly,evident
R1113	T1692	T1690	acomp	evident,is
R1114	T1693	T1690	prep	in,is
R1115	T1694	T1695	det	the,fibers
R1116	T1695	T1693	pobj	fibers,in
R1117	T1696	T1697	amod	mixed,II
R1118	T1697	T1695	nummod	II,fibers
R1119	T1698	T1697	nmod	type,II
R1120	T1699	T1697	nummod	I,II
R1121	T1700	T1697	punct	/,II
R1122	T1701	T1695	prep	of,fibers
R1123	T1702	T1703	det	the,hindlimb
R1124	T1703	T1701	pobj	hindlimb,of
R1125	T1704	T1705	punct	(,Figure
R1126	T1705	T1690	parataxis	Figure,is
R1127	T1706	T1705	nummod	2B,Figure
R1128	T1707	T1705	punct	),Figure
R1129	T1708	T1675	punct	.,found
R1130	T1710	T1711	advmod	Indeed,revealed
R1131	T1712	T1711	punct	", ",revealed
R1132	T1713	T1714	amod	metachromatic,staining
R1133	T1714	T1711	nsubj	staining,revealed
R1134	T1715	T1716	det	a,transformation
R1135	T1716	T1711	dobj	transformation,revealed
R1136	T1717	T1716	amod	substantial,transformation
R1137	T1718	T1719	compound	muscle,fiber
R1138	T1719	T1716	compound	fiber,transformation
R1139	T1720	T1721	punct	(,Figure
R1140	T1721	T1711	parataxis	Figure,revealed
R1141	T1722	T1721	nummod	2C,Figure
R1142	T1723	T1721	punct	),Figure
R1143	T1724	T1711	punct	.,revealed
R1144	T1726	T1727	prep	In,estimated
R1145	T1728	T1729	compound	gastrocnemius,muscle
R1146	T1729	T1726	pobj	muscle,In
R1147	T1730	T1727	punct	", ",estimated
R1148	T1731	T1727	nsubj	we,estimated
R1149	T1732	T1733	mark	that,was
R1150	T1733	T1727	ccomp	was,estimated
R1151	T1734	T1733	expl	there,was
R1152	T1735	T1736	det	a,increase
R1153	T1736	T1733	attr	increase,was
R1154	T1737	T1736	amod	2-fold,increase
R1155	T1738	T1736	prep	of,increase
R1156	T1739	T1740	nmod	type,fibers
R1157	T1740	T1738	pobj	fibers,of
R1158	T1741	T1739	nummod	I,type
R1159	T1742	T1727	punct	.,estimated
R1160	T1744	T1745	det	A,component
R1161	T1745	T1747	nsubj	component,is
R1162	T1746	T1745	amod	diagnostic,component
R1163	T1748	T1745	prep	of,component
R1164	T1749	T1750	amod	oxidative,fibers
R1165	T1750	T1748	pobj	fibers,of
R1166	T1751	T1752	poss	their,content
R1167	T1752	T1747	attr	content,is
R1168	T1753	T1752	amod	high,content
R1169	T1754	T1752	nmod	myoglobin,content
R1170	T1755	T1754	cc	and,myoglobin
R1171	T1756	T1754	conj	mitochondrial,myoglobin
R1172	T1757	T1752	punct	", ",content
R1173	T1758	T1759	dep	which,supported
R1174	T1759	T1752	relcl	supported,content
R1175	T1760	T1759	auxpass	is,supported
R1176	T1761	T1759	agent	by,supported
R1177	T1762	T1763	det	the,analysis
R1178	T1763	T1761	pobj	analysis,by
R1179	T1764	T1763	compound	mRNA,analysis
R1180	T1765	T1763	acl	shown,analysis
R1181	T1766	T1765	prep	in,shown
R1182	T1767	T1766	pobj	Figure,in
R1183	T1768	T1767	nummod	3A,Figure
R1184	T1769	T1747	punct	.,is
R1185	T1771	T1772	prep	In,elevated
R1186	T1773	T1771	pobj	addition,In
R1187	T1774	T1773	prep	to,addition
R1188	T1775	T1774	pobj	myoglobin,to
R1189	T1776	T1772	punct	", ",elevated
R1190	T1777	T1778	amod	mitochondrial,components
R1191	T1778	T1772	nsubjpass	components,elevated
R1192	T1779	T1778	prep	for,components
R1193	T1780	T1781	compound	electron,transfer
R1194	T1781	T1779	pobj	transfer,for
R1195	T1782	T1783	punct	(,c
R1196	T1783	T1778	parataxis	c,components
R1197	T1784	T1783	compound	cytochrome,c
R1198	T1785	T1783	cc	and,c
R1199	T1786	T1787	compound	cytochrome,c
R1200	T1787	T1788	compound	c,oxidase
R1201	T1788	T1783	conj	oxidase,c
R1202	T1789	T1790	punct	[,COX
R1203	T1790	T1788	parataxis	COX,oxidase
R1204	T1791	T1790	punct	],COX
R1205	T1792	T1783	appos	II,c
R1206	T1793	T1792	cc	and,II
R1207	T1794	T1792	conj	IV,II
R1208	T1795	T1783	punct	),c
R1209	T1796	T1778	cc	and,components
R1210	T1797	T1798	amod	fatty,acid
R1211	T1798	T1800	compound	acid,enzymes
R1212	T1799	T1798	punct	-,acid
R1213	T1800	T1778	conj	enzymes,components
R1214	T1801	T1802	compound	β,oxidation
R1215	T1802	T1800	compound	oxidation,enzymes
R1216	T1803	T1802	punct	-,oxidation
R1217	T1804	T1772	auxpass	were,elevated
R1218	T1805	T1806	punct	(,data
R1219	T1806	T1772	parataxis	data,elevated
R1220	T1807	T1806	dep	Figure,data
R1221	T1808	T1807	nummod	3A,Figure
R1222	T1809	T1806	punct	;,data
R1223	T1810	T1806	amod	unpublished,data
R1224	T1811	T1806	punct	),data
R1225	T1812	T1772	punct	.,elevated
R1226	T1814	T1815	det	These,effects
R1227	T1815	T1816	nsubj	effects,appear
R1228	T1817	T1818	aux	to,be
R1229	T1818	T1816	xcomp	be,appear
R1230	T1819	T1820	amod	direct,consequences
R1231	T1820	T1818	attr	consequences,be
R1232	T1821	T1820	prep	of,consequences
R1233	T1822	T1823	compound	PPARδ,activation
R1234	T1823	T1821	pobj	activation,of
R1235	T1824	T1818	punct	", ",be
R1236	T1825	T1826	mark	as,remained
R1237	T1826	T1818	advcl	remained,be
R1238	T1827	T1826	nsubj	levels,remained
R1239	T1828	T1827	prep	of,levels
R1240	T1829	T1828	pobj	PGC,of
R1241	T1830	T1829	punct	-,PGC
R1242	T1831	T1829	nummod	1α,PGC
R1243	T1832	T1829	punct	", ",PGC
R1244	T1833	T1834	det	a,coactivator
R1245	T1834	T1829	appos	coactivator,PGC
R1246	T1835	T1834	acl	involved,coactivator
R1247	T1836	T1835	prep	in,involved
R1248	T1837	T1838	compound	muscle,fiber
R1249	T1838	T1839	compound	fiber,switch
R1250	T1839	T1836	pobj	switch,in
R1251	T1840	T1839	cc	and,switch
R1252	T1841	T1842	amod	mitochondrial,biogenesis
R1253	T1842	T1839	conj	biogenesis,switch
R1254	T1843	T1844	punct	(,Wu
R1255	T1844	T1835	meta	Wu,involved
R1256	T1845	T1844	nmod	et,Wu
R1257	T1846	T1844	nmod	al.,Wu
R1258	T1847	T1844	nummod	1999,Wu
R1259	T1848	T1844	punct	;,Wu
R1260	T1849	T1844	nmod	Lehman,Wu
R1261	T1850	T1844	nmod	et,Wu
R1262	T1851	T1844	nmod	al.,Wu
R1263	T1852	T1844	nummod	2000,Wu
R1264	T1853	T1844	punct	;,Wu
R1265	T1854	T1844	nmod	Lin,Wu
R1266	T1855	T1844	nmod	et,Wu
R1267	T1856	T1844	nmod	al.,Wu
R1268	T1857	T1844	nummod	2002,Wu
R1269	T1858	T1844	punct	),Wu
R1270	T1859	T1826	punct	", ",remained
R1271	T1860	T1826	oprd	unchanged,remained
R1272	T1861	T1816	punct	.,appear
R1273	T1863	T1864	compound	Southern,blot
R1274	T1864	T1865	compound	blot,analysis
R1275	T1865	T1866	nsubj	analysis,detected
R1276	T1867	T1868	det	a,number
R1277	T1868	T1866	dobj	number,detected
R1278	T1869	T1870	advmod	substantially,higher
R1279	T1870	T1868	amod	higher,number
R1280	T1871	T1868	compound	copy,number
R1281	T1872	T1868	prep	of,number
R1282	T1873	T1874	det	the,DNA
R1283	T1874	T1872	pobj	DNA,of
R1284	T1875	T1874	amod	mitochondrial,DNA
R1285	T1876	T1877	npadvmod	genome,encoded
R1286	T1877	T1874	amod	encoded,DNA
R1287	T1878	T1877	punct	–,encoded
R1288	T1879	T1874	compound	COXII,DNA
R1289	T1880	T1866	prep	in,detected
R1290	T1881	T1882	det	the,mice
R1291	T1882	T1880	pobj	mice,in
R1292	T1883	T1882	amod	transgenic,mice
R1293	T1884	T1885	punct	(,Figure
R1294	T1885	T1866	parataxis	Figure,detected
R1295	T1886	T1885	nummod	3B,Figure
R1296	T1887	T1885	punct	),Figure
R1297	T1888	T1866	punct	.,detected
R1298	T1890	T1891	amod	Mitochondrial,DNA
R1299	T1891	T1892	nsubjpass	DNA,increased
R1300	T1893	T1892	auxpass	was,increased
R1301	T1894	T1892	advmod	2.3,increased
R1302	T1895	T1894	punct	-,2.3
R1303	T1896	T1894	advmod	fold,2.3
R1304	T1897	T1892	prep	in,increased
R1305	T1898	T1899	compound	gastrocnemius,muscle
R1306	T1899	T1897	pobj	muscle,in
R1307	T1900	T1899	prep	of,muscle
R1308	T1901	T1902	det	the,mice
R1309	T1902	T1900	pobj	mice,of
R1310	T1903	T1902	amod	transgenic,mice
R1311	T1904	T1905	punct	(,Figure
R1312	T1905	T1892	parataxis	Figure,increased
R1313	T1906	T1905	nummod	3C,Figure
R1314	T1907	T1905	punct	),Figure
R1315	T1908	T1892	punct	.,increased
R1316	T1910	T1911	det	These,results
R1317	T1911	T1912	nsubj	results,reveal
R1318	T1913	T1914	det	a,stimulation
R1319	T1914	T1912	dobj	stimulation,reveal
R1320	T1915	T1914	amod	marked,stimulation
R1321	T1916	T1914	prep	of,stimulation
R1322	T1917	T1918	amod	mitochondrial,biogenesis
R1323	T1918	T1916	pobj	biogenesis,of
R1324	T1919	T1912	cc	and,reveal
R1325	T1920	T1921	advmod	further,support
R1326	T1921	T1912	conj	support,reveal
R1327	T1922	T1923	det	the,idea
R1328	T1923	T1921	dobj	idea,support
R1329	T1924	T1925	mark	that,is
R1330	T1925	T1923	acl	is,idea
R1331	T1926	T1925	expl	there,is
R1332	T1927	T1928	det	a,switch
R1333	T1928	T1925	attr	switch,is
R1334	T1929	T1930	compound	muscle,fiber
R1335	T1930	T1928	compound	fiber,switch
R1336	T1931	T1912	punct	.,reveal
R1337	T1933	T1934	det	This,conclusion
R1338	T1934	T1935	nsubjpass	conclusion,confirmed
R1339	T1936	T1935	auxpass	was,confirmed
R1340	T1937	T1935	advmod	also,confirmed
R1341	T1938	T1935	prep	by,confirmed
R1342	T1939	T1940	compound	Western,blot
R1343	T1940	T1941	compound	blot,analysis
R1344	T1941	T1938	pobj	analysis,by
R1345	T1942	T1935	punct	.,confirmed
R1346	T1944	T1945	mark	As,shown
R1347	T1945	T1946	advcl	shown,increased
R1348	T1947	T1945	prep	in,shown
R1349	T1948	T1947	pobj	Figure,in
R1350	T1949	T1948	nummod	3D,Figure
R1351	T1950	T1946	punct	", ",increased
R1352	T1951	T1952	det	the,proteins
R1353	T1952	T1946	nsubjpass	proteins,increased
R1354	T1953	T1952	amod	characteristic,proteins
R1355	T1954	T1955	nmod	type,fiber
R1356	T1955	T1952	compound	fiber,proteins
R1357	T1956	T1954	nummod	I,type
R1358	T1957	T1952	punct	", ",proteins
R1359	T1958	T1959	amod	such,as
R1360	T1959	T1952	prep	as,proteins
R1361	T1960	T1959	pobj	myoglobin,as
R1362	T1961	T1960	cc	and,myoglobin
R1363	T1962	T1963	nmod	cytochrome,b
R1364	T1963	T1960	conj	b,myoglobin
R1365	T1964	T1963	nmod	c,b
R1366	T1965	T1964	cc	and,c
R1367	T1966	T1946	punct	", ",increased
R1368	T1967	T1946	auxpass	were,increased
R1369	T1968	T1946	advmod	significantly,increased
R1370	T1969	T1946	punct	.,increased
R1371	T1971	T1972	advmod	More,importantly
R1372	T1972	T1973	advmod	importantly,induced
R1373	T1973	T1990	ccomp	induced,accompanied
R1374	T1974	T1973	punct	", ",induced
R1375	T1975	T1976	det	the,protein
R1376	T1976	T1973	nsubjpass	protein,induced
R1377	T1977	T1976	amod	specialized,protein
R1378	T1978	T1976	compound	contraction,protein
R1379	T1979	T1976	appos	troponin,protein
R1380	T1980	T1979	nummod	I,troponin
R1381	T1981	T1982	punct	(,slow
R1382	T1982	T1976	parataxis	slow,protein
R1383	T1983	T1982	punct	),slow
R1384	T1984	T1976	prep	of,protein
R1385	T1985	T1986	nmod	type,fiber
R1386	T1986	T1984	pobj	fiber,of
R1387	T1987	T1985	nummod	I,type
R1388	T1988	T1973	auxpass	was,induced
R1389	T1989	T1973	advmod	robustly,induced
R1390	T1991	T1990	punct	;,accompanied
R1391	T1992	T1990	nsubjpass	this,accompanied
R1392	T1993	T1990	auxpass	was,accompanied
R1393	T1994	T1990	agent	by,accompanied
R1394	T1995	T1996	det	a,reduction
R1395	T1996	T1994	pobj	reduction,by
R1396	T1997	T1996	amod	marked,reduction
R1397	T1998	T1996	prep	of,reduction
R1398	T1999	T2000	det	the,protein
R1399	T2000	T1998	pobj	protein,of
R1400	T2001	T2000	amod	specialized,protein
R1401	T2002	T2000	compound	contraction,protein
R1402	T2003	T2000	appos	troponin,protein
R1403	T2004	T2003	nummod	I,troponin
R1404	T2005	T2006	punct	(,fast
R1405	T2006	T2003	parataxis	fast,troponin
R1406	T2007	T2006	punct	),fast
R1407	T2008	T2000	prep	of,protein
R1408	T2009	T2010	nmod	type,fiber
R1409	T2010	T2008	pobj	fiber,of
R1410	T2011	T2009	nummod	II,type
R1411	T2012	T1990	punct	", ",accompanied
R1412	T2013	T1990	advcl	indicating,accompanied
R1413	T2014	T2015	det	a,degree
R1414	T2015	T2013	dobj	degree,indicating
R1415	T2016	T2015	amod	high,degree
R1416	T2017	T2015	prep	of,degree
R1417	T2018	T2019	compound	fiber,transformation
R1418	T2019	T2017	pobj	transformation,of
R1419	T2020	T1990	punct	.,accompanied
R1420	T2022	T2023	nsubj	We,examined
R1421	T2024	T2023	advmod	next,examined
R1422	T2025	T2026	mark	whether,induce
R1423	T2026	T2023	ccomp	induce,examined
R1424	T2027	T2028	amod	acute,activation
R1425	T2028	T2026	nsubj	activation,induce
R1426	T2029	T2028	prep	of,activation
R1427	T2030	T2031	amod	endogenous,PPARδ
R1428	T2031	T2029	pobj	PPARδ,of
R1429	T2032	T2026	aux	would,induce
R1430	T2033	T2034	amod	similar,genes
R1431	T2034	T2026	dobj	genes,induce
R1432	T2035	T2034	compound	target,genes
R1433	T2036	T2023	punct	.,examined
R1434	T2038	T2039	prep	In,found
R1435	T2040	T2038	pobj	agreement,In
R1436	T2041	T2040	prep	with,agreement
R1437	T2042	T2043	det	the,effects
R1438	T2043	T2041	pobj	effects,with
R1439	T2044	T2043	amod	chronic,effects
R1440	T2045	T2043	prep	in,effects
R1441	T2046	T2047	det	the,mice
R1442	T2047	T2045	pobj	mice,in
R1443	T2048	T2047	amod	transgenic,mice
R1444	T2049	T2039	punct	", ",found
R1445	T2050	T2039	nsubj	we,found
R1446	T2051	T2052	mark	that,upregulated
R1447	T2052	T2039	ccomp	upregulated,found
R1448	T2053	T2052	punct	", ",upregulated
R1449	T2054	T2052	prep	after,upregulated
R1450	T2055	T2054	pobj	treatment,after
R1451	T2056	T2055	prep	of,treatment
R1452	T2057	T2058	amod	wild,type
R1453	T2058	T2060	compound	type,mice
R1454	T2059	T2058	punct	-,type
R1455	T2060	T2056	pobj	mice,of
R1456	T2061	T2060	compound	C57B6J,mice
R1457	T2062	T2055	prep	with,treatment
R1458	T2063	T2064	det	the,GW501516
R1459	T2064	T2062	pobj	GW501516,with
R1460	T2065	T2066	npadvmod	PPARδ,specific
R1461	T2066	T2064	amod	specific,GW501516
R1462	T2067	T2066	punct	-,specific
R1463	T2068	T2064	compound	agonist,GW501516
R1464	T2069	T2055	prep	for,treatment
R1465	T2070	T2071	advmod	only,d
R1466	T2071	T2069	pobj	d,for
R1467	T2072	T2071	nummod	10,d
R1468	T2073	T2052	punct	", ",upregulated
R1469	T2074	T2052	nsubjpass	genes,upregulated
R1470	T2075	T2074	prep	for,genes
R1471	T2076	T2077	amod	slow,fiber
R1472	T2077	T2078	nmod	fiber,proteins
R1473	T2078	T2075	pobj	proteins,for
R1474	T2079	T2078	amod	contractile,proteins
R1475	T2080	T2078	punct	", ",proteins
R1476	T2081	T2082	amod	mitochondrial,biogenesis
R1477	T2082	T2078	conj	biogenesis,proteins
R1478	T2083	T2082	punct	", ",biogenesis
R1479	T2084	T2082	cc	and,biogenesis
R1480	T2085	T2086	compound	β,oxidation
R1481	T2086	T2082	conj	oxidation,biogenesis
R1482	T2087	T2086	punct	-,oxidation
R1483	T2088	T2052	auxpass	were,upregulated
R1484	T2089	T2052	advmod	all,upregulated
R1485	T2090	T2091	punct	(,Figure
R1486	T2092	T2091	nummod	3E,Figure
R1487	T2091	T2052	parataxis	Figure,upregulated
R1488	T2093	T2091	punct	),Figure
R1489	T2094	T2039	punct	.,found
R1490	T2096	T2097	nsubj	This,indicates
R1491	T2098	T2099	mark	that,achieved
R1492	T2099	T2097	ccomp	achieved,indicates
R1493	T2100	T2101	amod	rapid,changes
R1494	T2101	T2099	nsubjpass	changes,achieved
R1495	T2102	T2100	punct	", ",rapid
R1496	T2103	T2100	conj	systematic,rapid
R1497	T2104	T2103	punct	", ",systematic
R1498	T2105	T2103	cc	and,systematic
R1499	T2106	T2103	conj	coordinated,systematic
R1500	T2107	T2101	prep	of,changes
R1501	T2108	T2109	compound	muscle,properties
R1502	T2109	T2107	pobj	properties,of
R1503	T2110	T2109	compound	fiber,properties
R1504	T2111	T2101	prep	toward,changes
R1505	T2112	T2111	pobj	type,toward
R1506	T2113	T2112	nummod	I,type
R1507	T2114	T2099	aux	can,achieved
R1508	T2115	T2099	auxpass	be,achieved
R1509	T2116	T2099	prep	by,achieved
R1510	T2117	T2116	pobj	activation,by
R1511	T2118	T2117	prep	of,activation
R1512	T2119	T2120	det	the,pathway
R1513	T2120	T2118	pobj	pathway,of
R1514	T2121	T2120	amod	endogenous,pathway
R1515	T2122	T2120	compound	PPARδ,pathway
R1516	T2123	T2097	punct	.,indicates
R3371	T4688	T4687	prep	of,Expression
R3372	T4689	T4690	amod	Endogenous,Transgene
R3373	T4690	T4688	pobj	Transgene,of
R3374	T4691	T4690	nmod	PPARδ,Transgene
R3375	T4692	T4691	cc	and,PPARδ
R3376	T4693	T4694	compound	VP16,PPARδ
R3377	T4694	T4691	conj	PPARδ,PPARδ
R3378	T4695	T4694	punct	-,PPARδ
R3379	T4696	T4687	prep	in,Expression
R3380	T4697	T4696	pobj	Muscle,in
R3381	T4699	T4700	punct	(,A
R3382	T4700	T4701	meta	A,hybridized
R3383	T4702	T4700	punct	),A
R3384	T4703	T4704	amod	Pooled,RNA
R3385	T4704	T4701	nsubjpass	RNA,hybridized
R3386	T4705	T4704	acl	isolated,RNA
R3387	T4706	T4705	prep	from,isolated
R3388	T4707	T4708	amod	various,muscles
R3389	T4708	T4706	pobj	muscles,from
R3390	T4709	T4708	prep	of,muscles
R3391	T4710	T4711	nummod	five,mice
R3392	T4711	T4709	pobj	mice,of
R3393	T4712	T4713	amod	wild,type
R3394	T4713	T4711	nmod	type,mice
R3395	T4714	T4713	punct	-,type
R3396	T4715	T4711	amod	male,mice
R3397	T4716	T4711	compound	C57B6,mice
R3398	T4717	T4701	auxpass	was,hybridized
R3399	T4718	T4701	prep	with,hybridized
R3400	T4719	T4720	amod	indicated,probes
R3401	T4720	T4718	pobj	probes,with
R3402	T4721	T4701	punct	.,hybridized
R3403	T4724	T4723	punct	", ",EDL
R3404	T4725	T4726	compound	extensor,longus
R3405	T4726	T4723	appos	longus,EDL
R3406	T4727	T4726	compound	digitorum,longus
R3407	T4728	T4723	punct	;,EDL
R3408	T4729	T4723	appos	Gastro,EDL
R3409	T4730	T4729	punct	", ",Gastro
R3410	T4731	T4729	appos	gastrocnemius,Gastro
R3411	T4732	T4723	punct	.,EDL
R3412	T4734	T4735	punct	(,B
R3413	T4735	T4736	meta	B,probed
R3414	T4737	T4735	punct	),B
R3415	T4738	T4739	amod	Pooled,proteins
R3416	T4739	T4736	nsubjpass	proteins,probed
R3417	T4740	T4739	amod	nuclear,proteins
R3418	T4741	T4742	punct	(,μg
R3419	T4742	T4739	parataxis	μg,proteins
R3420	T4743	T4742	nummod	15,μg
R3421	T4744	T4745	punct	/,lane
R3422	T4745	T4742	prep	lane,μg
R3423	T4746	T4742	punct	),μg
R3424	T4747	T4739	acl	isolated,proteins
R3425	T4748	T4747	prep	from,isolated
R3426	T4749	T4748	pobj	muscles,from
R3427	T4750	T4749	prep	of,muscles
R3428	T4751	T4752	nummod	five,C57B6
R3429	T4752	T4750	pobj	C57B6,of
R3430	T4753	T4754	amod	wild,type
R3431	T4754	T4752	nmod	type,C57B6
R3432	T4755	T4754	punct	-,type
R3433	T4756	T4752	amod	male,C57B6
R3434	T4757	T4736	auxpass	were,probed
R3435	T4758	T4736	prep	with,probed
R3436	T4759	T4760	amod	anti-PPARδ,antibody
R3437	T4760	T4758	pobj	antibody,with
R3438	T4761	T4736	punct	.,probed
R3439	T4763	T4764	compound	RNA,polymerase
R3440	T4764	T4765	nsubjpass	polymerase,shown
R3441	T4766	T4764	nummod	II,polymerase
R3442	T4767	T4764	punct	(,polymerase
R3443	T4768	T4764	appos	Pol,polymerase
R3444	T4769	T4768	nummod	II,Pol
R3445	T4770	T4764	punct	),polymerase
R3446	T4771	T4765	auxpass	is,shown
R3447	T4772	T4765	prep	as,shown
R3448	T4773	T4774	det	a,control
R3449	T4774	T4772	pobj	control,as
R3450	T4775	T4774	compound	loading,control
R3451	T4776	T4765	punct	.,shown
R3452	T4778	T4779	punct	(,C
R3453	T4779	T4780	meta	C,Expression
R3454	T4781	T4779	punct	),C
R3455	T4782	T4780	prep	of,Expression
R3456	T4783	T4784	det	the,transgene
R3457	T4784	T4782	pobj	transgene,of
R3458	T4785	T4786	compound	VP16,PPARδ
R3459	T4786	T4784	compound	PPARδ,transgene
R3460	T4787	T4786	punct	-,PPARδ
R3461	T4788	T4780	prep	in,Expression
R3462	T4789	T4790	amod	various,tissues
R3463	T4790	T4788	pobj	tissues,in
R3464	T4791	T4780	punct	.,Expression
R3465	T4793	T4794	nummod	10,μg
R3466	T4794	T4795	nsubjpass	μg,hybridized
R3467	T4796	T4794	prep	of,μg
R3468	T4797	T4798	amod	total,RNA
R3469	T4798	T4796	pobj	RNA,of
R3470	T4799	T4798	prep	from,RNA
R3471	T4800	T4801	det	each,tissue
R3472	T4801	T4799	pobj	tissue,from
R3473	T4802	T4795	auxpass	was,hybridized
R3474	T4803	T4795	prep	with,hybridized
R3475	T4804	T4805	det	a,probe
R3476	T4805	T4803	pobj	probe,with
R3477	T4806	T4807	compound	VP16,cDNA
R3478	T4807	T4805	compound	cDNA,probe
R3479	T4808	T4795	punct	.,hybridized
R3480	T4810	T4811	compound	Gastrocnemius,muscle
R3481	T4811	T4812	nsubjpass	muscle,used
R3482	T4813	T4812	auxpass	was,used
R3483	T4814	T4812	advmod	here,used
R3484	T4815	T4812	punct	.,used
R3485	T4817	T4818	punct	(,D
R3486	T4818	T4819	meta	D,probed
R3487	T4820	T4818	punct	),D
R3488	T4821	T4822	amod	Nuclear,proteins
R3489	T4822	T4819	nsubjpass	proteins,probed
R3490	T4823	T4824	punct	(,μg
R3491	T4824	T4822	parataxis	μg,proteins
R3492	T4825	T4824	nummod	15,μg
R3493	T4826	T4827	punct	/,lane
R3494	T4827	T4824	prep	lane,μg
R3495	T4828	T4824	punct	),μg
R3496	T4829	T4822	acl	isolated,proteins
R3497	T4830	T4829	prep	from,isolated
R3498	T4831	T4832	compound	gastrocnemius,muscle
R3499	T4832	T4830	pobj	muscle,from
R3500	T4833	T4832	prep	of,muscle
R3501	T4834	T4835	det	the,mice
R3502	T4835	T4833	pobj	mice,of
R3503	T4836	T4835	amod	transgenic,mice
R3504	T4837	T4838	punct	(,TG
R3505	T4838	T4835	parataxis	TG,mice
R3506	T4839	T4838	punct	),TG
R3507	T4840	T4835	cc	and,mice
R3508	T4841	T4842	det	the,littermates
R3509	T4842	T4835	conj	littermates,mice
R3510	T4843	T4844	amod	wild,type
R3511	T4844	T4842	compound	type,littermates
R3512	T4845	T4844	punct	-,type
R3513	T4846	T4847	punct	(,WT
R3514	T4847	T4842	parataxis	WT,littermates
R3515	T4848	T4847	punct	),WT
R3516	T4849	T4819	auxpass	were,probed
R3517	T4850	T4819	prep	with,probed
R3518	T4851	T4852	amod	indicated,antibodies
R3519	T4852	T4850	pobj	antibodies,with
R3520	T4853	T4819	punct	.,probed
R3521	T4855	T4856	det	The,band
R3522	T4856	T4860	nsubj	band,serves
R3523	T4857	T4856	amod	upper,band
R3524	T4858	T4856	punct	", ",band
R3525	T4859	T4856	amod	nonspecific,band
R3526	T4861	T4862	dep	that,cross-reacted
R3527	T4862	T4856	relcl	cross-reacted,band
R3528	T4863	T4862	prep	with,cross-reacted
R3529	T4864	T4865	det	the,antibody
R3530	T4865	T4863	pobj	antibody,with
R3531	T4866	T4865	amod	anti-PPARδ,antibody
R3532	T4867	T4868	det	a,control
R3533	T4868	T4860	dobj	control,serves
R3534	T4869	T4868	compound	loading,control
R3535	T4870	T4860	punct	.,serves
R3536	T4894	T4895	amod	Increased,Fibers
R3537	T4896	T4895	amod	Oxidative,Fibers
R3538	T4897	T4895	nmod	Type,Fibers
R3539	T4898	T4897	nummod	I,Type
R3540	T4899	T4895	prep	in,Fibers
R3541	T4900	T4901	det	the,Mice
R3542	T4901	T4899	pobj	Mice,in
R3543	T4902	T4901	amod	Transgenic,Mice
R3544	T4904	T4905	punct	(,A
R3545	T4905	T4906	meta	A,are
R3546	T4907	T4905	cc	and,A
R3547	T4908	T4905	conj	B,A
R3548	T4909	T4908	punct	),B
R3549	T4910	T4906	nsubj	Muscles,are
R3550	T4911	T4910	prep	in,Muscles
R3551	T4912	T4913	amod	transgenic,mice
R3552	T4913	T4911	pobj	mice,in
R3553	T4914	T4915	punct	(,TG
R3554	T4915	T4913	parataxis	TG,mice
R3555	T4916	T4915	punct	),TG
R3556	T4917	T4906	acomp	redder,are
R3557	T4918	T4917	prep	than,redder
R3558	T4919	T4918	pobj	those,than
R3559	T4920	T4919	prep	in,those
R3560	T4921	T4922	amod	wild,type
R3561	T4922	T4924	compound	type,mice
R3562	T4923	T4922	punct	-,type
R3563	T4924	T4920	pobj	mice,in
R3564	T4925	T4926	punct	(,WT
R3565	T4926	T4924	parataxis	WT,mice
R3566	T4927	T4926	punct	),WT
R3567	T4928	T4906	punct	.,are
R3568	T4930	T4931	punct	(,C
R3569	T4931	T4932	meta	C,staining
R3570	T4933	T4931	punct	),C
R3571	T4934	T4932	amod	Metachromatic,staining
R3572	T4935	T4932	prep	of,staining
R3573	T4936	T4937	det	the,muscle
R3574	T4937	T4935	pobj	muscle,of
R3575	T4938	T4937	nmod	type,muscle
R3576	T4939	T4938	nummod	II,type
R3577	T4940	T4937	compound	plantaris,muscle
R3578	T4941	T4932	punct	.,staining
R3579	T4943	T4944	nmod	Type,fibers
R3580	T4944	T4946	nsubjpass	fibers,stained
R3581	T4945	T4943	nummod	I,Type
R3582	T4947	T4946	auxpass	are,stained
R3583	T4948	T4949	advmod	dark,blue
R3584	T4949	T4946	oprd	blue,stained
R3585	T4950	T4946	punct	.,stained
R3586	T5034	T5035	nsubj	Activation,Induces
R3587	T5036	T5034	prep	of,Activation
R3588	T5037	T5036	pobj	PPARδ,of
R3589	T5038	T5035	dobj	Genes,Induces
R3590	T5039	T5038	amod	Typical,Genes
R3591	T5040	T5039	prep	for,Typical
R3592	T5041	T5042	nmod	Type,Fibers
R3593	T5042	T5040	pobj	Fibers,for
R3594	T5043	T5041	nummod	I,Type
R3595	T5044	T5035	cc	and,Induces
R3596	T5045	T5035	conj	Promotes,Induces
R3597	T5046	T5047	amod	Mitochondrial,Biogenesis
R3598	T5047	T5045	dobj	Biogenesis,Promotes
R3599	T5049	T5050	punct	(,A
R3600	T5050	T5051	meta	A,probed
R3601	T5052	T5050	punct	),A
R3602	T5053	T5054	amod	Total,RNA
R3603	T5054	T5051	nsubjpass	RNA,probed
R3604	T5055	T5056	punct	(,μg
R3605	T5056	T5054	parataxis	μg,RNA
R3606	T5057	T5056	nummod	10,μg
R3607	T5058	T5059	punct	/,lane
R3608	T5059	T5056	prep	lane,μg
R3609	T5060	T5056	punct	),μg
R3610	T5061	T5054	acl	prepared,RNA
R3611	T5062	T5061	prep	from,prepared
R3612	T5063	T5064	compound	gastrocnemius,muscle
R3613	T5064	T5062	pobj	muscle,from
R3614	T5065	T5064	prep	of,muscle
R3615	T5066	T5067	amod	transgenic,littermates
R3616	T5067	T5065	pobj	littermates,of
R3617	T5068	T5069	punct	(,TG
R3618	T5069	T5066	parataxis	TG,transgenic
R3619	T5070	T5069	punct	),TG
R3620	T5071	T5066	cc	and,transgenic
R3621	T5072	T5073	amod	wild,type
R3622	T5073	T5066	conj	type,transgenic
R3623	T5074	T5073	punct	-,type
R3624	T5075	T5076	punct	(,WT
R3625	T5076	T5073	parataxis	WT,type
R3626	T5077	T5076	punct	),WT
R3627	T5078	T5051	auxpass	was,probed
R3628	T5079	T5051	prep	with,probed
R3629	T5080	T5081	amod	indicated,probes
R3630	T5081	T5079	pobj	probes,with
R3631	T5082	T5051	punct	.,probed
R3632	T5084	T5085	det	The,increase
R3633	T5085	T5087	nsubjpass	increase,shown
R3634	T5086	T5085	amod	fold,increase
R3635	T5088	T5085	prep	of,increase
R3636	T5089	T5088	pobj	induction,of
R3637	T5090	T5089	prep	of,induction
R3638	T5091	T5092	det	each,gene
R3639	T5092	T5090	pobj	gene,of
R3640	T5093	T5087	auxpass	is,shown
R3641	T5094	T5087	punct	.,shown
R3642	T5096	T5097	punct	(,B
R3643	T5097	T5098	meta	B,digested
R3644	T5099	T5097	punct	),B
R3645	T5100	T5101	amod	Total,DNA
R3646	T5101	T5098	nsubjpass	DNA,digested
R3647	T5102	T5101	amod	genomic,DNA
R3648	T5103	T5104	punct	(,μg
R3649	T5104	T5101	parataxis	μg,DNA
R3650	T5105	T5104	nummod	10,μg
R3651	T5106	T5107	punct	/,lane
R3652	T5107	T5104	prep	lane,μg
R3653	T5108	T5104	punct	),μg
R3654	T5109	T5101	acl	prepared,DNA
R3655	T5110	T5109	prep	from,prepared
R3656	T5111	T5112	compound	gastrocnemius,muscle
R3657	T5112	T5110	pobj	muscle,from
R3658	T5113	T5098	auxpass	was,digested
R3659	T5114	T5098	prep	with,digested
R3660	T5115	T5114	pobj	Nco1,with
R3661	T5116	T5098	cc	and,digested
R3662	T5117	T5098	conj	subjected,digested
R3663	T5118	T5117	prep	to,subjected
R3664	T5119	T5120	compound	Southern,analysis
R3665	T5120	T5118	pobj	analysis,to
R3666	T5121	T5117	prep	with,subjected
R3667	T5122	T5123	nmod	COXII,probes
R3668	T5123	T5121	pobj	probes,with
R3669	T5124	T5125	punct	(,encoded
R3670	T5125	T5122	parataxis	encoded,COXII
R3671	T5126	T5127	amod	mitochondrial,genome
R3672	T5127	T5125	npadvmod	genome,encoded
R3673	T5128	T5125	punct	–,encoded
R3674	T5129	T5125	punct	),encoded
R3675	T5130	T5122	cc	and,COXII
R3676	T5131	T5122	conj	MCIP1,COXII
R3677	T5132	T5133	punct	(,encoded
R3678	T5133	T5131	parataxis	encoded,MCIP1
R3679	T5134	T5135	amod	nuclear,genome
R3680	T5135	T5133	npadvmod	genome,encoded
R3681	T5136	T5133	punct	–,encoded
R3682	T5137	T5133	punct	),encoded
R3683	T5138	T5123	compound	DNA,probes
R3684	T5139	T5098	punct	.,digested
R3685	T5141	T5142	punct	(,C
R3686	T5142	T5143	meta	C,collected
R3687	T5144	T5142	punct	),C
R3688	T5145	T5146	amod	Equal,amounts
R3689	T5146	T5143	nsubjpass	amounts,collected
R3690	T5147	T5146	prep	of,amounts
R3691	T5148	T5149	compound	gastrocnemius,muscle
R3692	T5149	T5147	pobj	muscle,of
R3693	T5150	T5143	auxpass	were,collected
R3694	T5151	T5143	prep	from,collected
R3695	T5152	T5153	preconj	both,mice
R3696	T5153	T5151	pobj	mice,from
R3697	T5154	T5153	amod	transgenic,mice
R3698	T5155	T5153	cc	and,mice
R3699	T5156	T5157	compound	control,littermates
R3700	T5157	T5153	conj	littermates,mice
R3701	T5158	T5143	punct	.,collected
R3702	T5160	T5161	amod	Total,DNA
R3703	T5161	T5163	nsubjpass	DNA,isolated
R3704	T5162	T5161	amod	mitochondrial,DNA
R3705	T5164	T5163	auxpass	was,isolated
R3706	T5165	T5163	cc	and,isolated
R3707	T5166	T5163	conj	separated,isolated
R3708	T5167	T5166	prep	on,separated
R3709	T5168	T5169	nummod	1,%
R3710	T5169	T5170	compound	%,gel
R3711	T5170	T5167	pobj	gel,on
R3712	T5171	T5170	compound	agarose,gel
R3713	T5172	T5163	punct	.,isolated
R3714	T5174	T5175	det	The,abundance
R3715	T5175	T5177	nsubjpass	abundance,presented
R3716	T5176	T5175	amod	relative,abundance
R3717	T5178	T5175	prep	of,abundance
R3718	T5179	T5180	amod	mitochondrial,DNA
R3719	T5180	T5178	pobj	DNA,of
R3720	T5181	T5175	prep	in,abundance
R3721	T5182	T5183	amod	transgenic,mice
R3722	T5183	T5181	pobj	mice,in
R3723	T5184	T5182	cc	and,transgenic
R3724	T5185	T5186	amod	wild,type
R3725	T5186	T5182	conj	type,transgenic
R3726	T5187	T5186	punct	-,type
R3727	T5188	T5177	auxpass	is,presented
R3728	T5189	T5177	punct	.,presented
R3729	T5191	T5192	punct	(,D
R3730	T5192	T5193	meta	D,analysis
R3731	T5194	T5192	punct	),D
R3732	T5195	T5196	compound	Western,blot
R3733	T5196	T5193	compound	blot,analysis
R3734	T5197	T5193	prep	of,analysis
R3735	T5198	T5199	compound	muscle,fiber
R3736	T5199	T5200	compound	fiber,markers
R3737	T5200	T5197	pobj	markers,of
R3738	T5201	T5200	cc	and,markers
R3739	T5202	T5203	amod	mitochondrial,components
R3740	T5203	T5200	conj	components,markers
R3741	T5204	T5193	punct	.,analysis
R3742	T5206	T5207	det	Each,lane
R3743	T5207	T5208	nsubjpass	lane,loaded
R3744	T5209	T5208	auxpass	was,loaded
R3745	T5210	T5208	prep	with,loaded
R3746	T5211	T5212	nummod	80,μg
R3747	T5212	T5210	pobj	μg,with
R3748	T5213	T5212	prep	of,μg
R3749	T5214	T5215	amod	total,extracts
R3750	T5215	T5213	pobj	extracts,of
R3751	T5216	T5217	compound	gastrocnemius,muscle
R3752	T5217	T5215	compound	muscle,extracts
R3753	T5218	T5208	punct	.,loaded
R3754	T5220	T5221	punct	(,E
R3755	T5221	T5222	meta	E,treated
R3756	T5223	T5221	punct	),E
R3757	T5224	T5225	amod	Wild,type
R3758	T5225	T5227	compound	type,mice
R3759	T5226	T5225	punct	-,type
R3760	T5227	T5222	nsubjpass	mice,treated
R3761	T5228	T5227	compound	C57B6,mice
R3762	T5229	T5222	auxpass	were,treated
R3763	T5230	T5222	prep	with,treated
R3764	T5231	T5230	pobj	vehicle,with
R3765	T5232	T5231	cc	or,vehicle
R3766	T5233	T5234	compound	PPARδ,agonist
R3767	T5234	T5235	compound	agonist,GW501516
R3768	T5235	T5231	conj	GW501516,vehicle
R3769	T5236	T5222	prep	for,treated
R3770	T5237	T5238	nummod	10,d
R3771	T5238	T5236	pobj	d,for
R3772	T5239	T5222	punct	.,treated
R3773	T5241	T5242	amod	Total,RNA
R3774	T5242	T5243	nsubjpass	RNA,probed
R3775	T5244	T5245	punct	(,μg
R3776	T5245	T5242	parataxis	μg,RNA
R3777	T5246	T5245	nummod	10,μg
R3778	T5247	T5248	punct	/,lane
R3779	T5248	T5245	prep	lane,μg
R3780	T5249	T5245	punct	),μg
R3781	T5250	T5242	acl	prepared,RNA
R3782	T5251	T5250	prep	from,prepared
R3783	T5252	T5253	det	the,muscle
R3784	T5253	T5251	pobj	muscle,from
R3785	T5254	T5253	compound	gastrocnemius,muscle
R3786	T5255	T5243	auxpass	was,probed
R3787	T5256	T5243	prep	with,probed
R3788	T5257	T5258	amod	indicated,probes
R3789	T5258	T5256	pobj	probes,with
R3790	T5259	T5243	punct	.,probed

2_test

Id	Subject	Object	Predicate	Lexical cue
15328533-12181572-84708275	535-539	12181572	denotes	2002
15328533-7678010-84708276	1932-1936	7678010	denotes	1993
15328533-10935638-84708277	1953-1957	10935638	denotes	2000
15328533-10412986-84708278	3747-3751	10412986	denotes	1999
15328533-11018072-84708279	3767-3771	11018072	denotes	2000
15328533-12181572-84708280	3784-3788	12181572	denotes	2002
T79074	535-539	12181572	denotes	2002
T71983	1932-1936	7678010	denotes	1993
T59671	1953-1957	10935638	denotes	2000
T42790	3747-3751	10412986	denotes	1999
T15051	3767-3771	11018072	denotes	2000
T23306	3784-3788	12181572	denotes	2002

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T1098	14-19	PR_EXT:000013057	denotes	PPARδ
T1099	29-35	UBERON_EXT:muscle_structure_or_tissue	denotes	Muscle
T1100	29-41	CL:0000187	denotes	Muscle Fiber
T1101	67-72	PR_EXT:000013057	denotes	PPARδ
T1102	76-82	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1103	76-88	CL:0000187	denotes	muscle fiber
T1104	119-129	GO:0010467	denotes	expression
T1105	173-178	PR_EXT:000013056	denotes	PPARα
T1106	185-193	SO_EXT:0001060	denotes	isoforms
T1107	246-251	PR_EXT:000013057	denotes	PPARδ
T1108	265-271	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1109	265-278	CL:0000187	denotes	muscle fibers
T1110	319-325	CL:0002211	denotes	type I
T1111	326-332	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1112	334-340	UBERON:0001389	denotes	soleus
T1113	354-361	CL:0002212	denotes	type II
T1114	367-373	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1115	375-400	UBERON:0001386	denotes	extensor digitorum longus
T1188	2986-2995	CL:0002212	denotes	II fibers
T1189	3003-3011	UBERON:0002103	denotes	hindlimb
T1190	3079-3085	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1191	3079-3091	CL:0000187	denotes	muscle fiber
T1192	3123-3143	UBERON:0001388	denotes	gastrocnemius muscle
T1193	3194-3207	CL:0002211	denotes	type I fibers
T1194	3235-3244	MOP:0000568	denotes	oxidative
T1195	3235-3251	CL:0002210	denotes	oxidative fibers
T1196	3266-3275	CHEBI_PR_EXT:myoglobin	denotes	myoglobin
T1197	3280-3293	GO:0005739	denotes	mitochondrial
T1198	3329-3333	CHEBI_SO_EXT:mRNA	denotes	mRNA
T1199	3378-3387	CHEBI_PR_EXT:myoglobin	denotes	myoglobin
T1200	3389-3402	GO:0005739	denotes	mitochondrial
T1201	3418-3426	CHEBI:10545	denotes	electron
T1202	3418-3435	MOP:0000615	denotes	electron transfer
T1203	3427-3435	GO_EXT:biological_movement_or_translocation_process	denotes	transfer
T1204	3437-3449	PR_EXT:000002199	denotes	cytochrome c
T1205	3437-3449	CHEBI:18070	denotes	cytochrome c
T1206	3454-3466	CHEBI:18070	denotes	cytochrome c
T1207	3454-3474	GO_EXT:0004129	denotes	cytochrome c oxidase
T1208	3454-3474	_FRAGMENT	denotes	cytochrome c oxidase
T1209	3481-3483	PR_EXT:000025365	denotes	II
T1210	3488-3490	PR_EXT:000005776	denotes	IV
T1211	3476-3479	GO_EXT:0004129	denotes	COX
T1212	3476-3479	_FRAGMENT	denotes	COX
T1213	3496-3501	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fatty
T1214	3496-3506	CHEBI:35366	denotes	fatty-acid
T1215	3496-3518	GO:0006635	denotes	fatty-acid β-oxidation
T1216	3509-3518	MOP:0000568	denotes	oxidation
T1217	3519-3526	CHEBI_GO_SO_EXT:enzyme	denotes	enzymes
T1218	3622-3627	PR_EXT:000013057	denotes	PPARδ
T1219	3653-3659	PR_EXT:000013059	denotes	PGC-1α
T1220	3687-3693	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1221	3687-3699	CL:0000187	denotes	muscle fiber
T1222	3711-3724	GO:0005739	denotes	mitochondrial
T1223	3725-3735	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T1265	4912-4919	CHEBI_GO_EXT:agonist	denotes	agonist
T1266	4920-4928	CHEBI:73726	denotes	GW501516
T1267	4944-4949	SO_EXT:0000704	denotes	genes
T1268	4954-4964	CL:0000189	denotes	slow fiber
T1269	4965-4976	GO:0006936	denotes	contractile
T1270	4977-4985	CHEBI_PR_EXT:protein	denotes	proteins
T1271	4987-5000	GO:0005739	denotes	mitochondrial
T1272	5001-5011	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T1273	5019-5028	MOP:0000568	denotes	oxidation
T1274	5038-5049	GO_EXT:positive_regulation	denotes	upregulated
T1275	5129-5135	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1276	5129-5141	CL:0000187	denotes	muscle fiber
T1277	5160-5166	CL:0002211	denotes	type I
T1278	5215-5220	PR_EXT:000013057	denotes	PPARδ
T4638	676-681	PR_EXT:000013057	denotes	PPARδ
T4639	686-690	PR_EXT:P06492	denotes	VP16
T4640	691-696	PR_EXT:000013057	denotes	PPARδ
T4641	697-706	SO_EXT:0000902	denotes	Transgene
T4642	710-716	UBERON_EXT:muscle_structure_or_tissue	denotes	Muscle
T4643	728-731	CHEBI_SO_EXT:RNA	denotes	RNA
T4644	754-761	UBERON:0005090	denotes	muscles
T4645	770-779	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T4646	780-784	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T4647	791-795	NCBITaxon:10088	denotes	mice
T4648	800-810	GO:0097617	denotes	hybridized
T4649	826-832	CHEBI_SO_EXT:molecular_probe	denotes	probes
T4650	834-837	UBERON:0001386	denotes	EDL
T4651	839-864	UBERON:0001386	denotes	extensor digitorum longus
T4652	866-872	UBERON:0001388	denotes	Gastro
T4653	874-887	UBERON:0001388	denotes	gastrocnemius
T4654	900-907	GO:0005634	denotes	nuclear
T4655	908-916	CHEBI_PR_EXT:protein	denotes	proteins
T4656	944-951	UBERON:0005090	denotes	muscles
T4657	960-969	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T4658	970-974	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T4659	1003-1008	PR_EXT:000013057	denotes	PPARδ
T4660	1009-1017	GO:0042571	denotes	antibody
T4661	1019-1022	CHEBI_SO_EXT:RNA	denotes	RNA
T4662	1019-1036	GO_EXT:0001055	denotes	RNA polymerase II
T4663	1038-1044	GO_EXT:0001055	denotes	Pol II
T4664	1081-1091	GO:0010467	denotes	Expression
T4665	1099-1103	PR_EXT:P06492	denotes	VP16
T4666	1104-1109	PR_EXT:000013057	denotes	PPARδ
T4667	1110-1119	SO_EXT:0000902	denotes	transgene
T4668	1131-1138	UBERON:0000479	denotes	tissues
T4669	1155-1158	CHEBI_SO_EXT:RNA	denotes	RNA
T4670	1169-1175	UBERON:0000479	denotes	tissue
T4671	1180-1190	GO:0097617	denotes	hybridized
T4672	1198-1202	PR_EXT:P06492	denotes	VP16
T4673	1203-1207	SO_EXT:cDNA	denotes	cDNA
T4674	1208-1213	CHEBI_SO_EXT:molecular_probe	denotes	probe
T4675	1215-1235	UBERON:0001388	denotes	Gastrocnemius muscle
T4676	1255-1262	GO:0005634	denotes	Nuclear
T4677	1263-1271	CHEBI_PR_EXT:protein	denotes	proteins
T4678	1299-1319	UBERON:0001388	denotes	gastrocnemius muscle
T4679	1327-1337	SO_EXT:transgenic_entity	denotes	transgenic
T4680	1338-1342	NCBITaxon:10088	denotes	mice
T4681	1344-1346	SO_EXT:transgenic_entity	denotes	TG
T4682	1356-1365	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T4683	1379-1381	SO_EXT:wild_type_entity_or_quality	denotes	WT
T4684	1410-1420	GO:0042571	denotes	antibodies
T4685	1483-1488	PR_EXT:000013057	denotes	PPARδ
T4686	1489-1497	GO:0042571	denotes	antibody
T4882	5281-5291	SO_EXT:transgenic_entity	denotes	Transgenic
T4883	5292-5296	NCBITaxon:10088	denotes	Mice
T4884	5307-5314	UBERON:0005090	denotes	Muscles
T4885	5318-5328	SO_EXT:transgenic_entity	denotes	transgenic
T4886	5329-5333	NCBITaxon:10088	denotes	mice
T4887	5335-5337	SO_EXT:transgenic_entity	denotes	TG
T4888	5364-5373	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T4889	5374-5378	NCBITaxon:10088	denotes	mice
T4890	5380-5382	SO_EXT:wild_type_entity_or_quality	denotes	WT
T4891	5419-5426	CL:0002212	denotes	type II
T4892	5427-5443	UBERON:0011905	denotes	plantaris muscle
T4893	5445-5458	CL:0002211	denotes	Type I fibers
T4951	5506-5511	PR_EXT:000013057	denotes	PPARδ
T4952	5520-5525	SO_EXT:0000704	denotes	Genes
T4953	5538-5551	CL:0002211	denotes	Type I Fibers
T4954	5565-5578	GO:0005739	denotes	Mitochondrial
T4955	5579-5589	GO_EXT:biogenesis_or_biosynthesis	denotes	Biogenesis
T4956	5600-5603	CHEBI_SO_EXT:RNA	denotes	RNA
T4957	5631-5651	UBERON:0001388	denotes	gastrocnemius muscle
T4958	5655-5665	SO_EXT:transgenic_entity	denotes	transgenic
T4959	5667-5669	SO_EXT:transgenic_entity	denotes	TG
T4960	5675-5684	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T4961	5686-5688	SO_EXT:wild_type_entity_or_quality	denotes	WT
T4962	5728-5734	CHEBI_SO_EXT:molecular_probe	denotes	probes
T4963	5775-5779	SO_EXT:0000704	denotes	gene
T4964	5800-5811	SO_EXT:genomic_DNA	denotes	genomic DNA
T4965	5808-5811	CHEBI_SO_EXT:DNA	denotes	DNA
T4966	5839-5859	UBERON:0001388	denotes	gastrocnemius muscle
T4967	5923-5928	PR_EXT:000025365	denotes	COXII
T4968	5930-5943	GO:0005739	denotes	mitochondrial
T4969	5944-5950	SO_EXT:0001026	denotes	genome
T4970	5951-5958	SO_EXT:sequence_coding_function	denotes	encoded
T4971	5964-5969	PR_EXT:000013829	denotes	MCIP1
T4972	5971-5978	GO:0005634	denotes	nuclear
T4973	5979-5985	SO_EXT:0001026	denotes	genome
T4974	5986-5993	SO_EXT:sequence_coding_function	denotes	encoded
T4975	5995-5998	CHEBI_SO_EXT:DNA	denotes	DNA
T4976	5999-6005	CHEBI_SO_EXT:molecular_probe	denotes	probes
T4977	6028-6048	UBERON:0001388	denotes	gastrocnemius muscle
T4978	6074-6084	SO_EXT:transgenic_entity	denotes	transgenic
T4979	6085-6089	NCBITaxon:10088	denotes	mice
T4980	6121-6134	GO:0005739	denotes	mitochondrial
T4981	6121-6138	SO:0001032	denotes	mitochondrial DNA
T4982	6135-6138	CHEBI_SO_EXT:DNA	denotes	DNA
T4983	6172-6179	CHEBI:2511	denotes	agarose
T4984	6211-6224	GO:0005739	denotes	mitochondrial
T4985	6211-6228	SO:0001032	denotes	mitochondrial DNA
T4986	6225-6228	CHEBI_SO_EXT:DNA	denotes	DNA
T4987	6232-6242	SO_EXT:transgenic_entity	denotes	transgenic
T4988	6247-6256	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T4989	6257-6261	NCBITaxon:10088	denotes	mice
T4990	6305-6311	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T4991	6305-6317	CL:0000187	denotes	muscle fiber
T4992	6318-6325	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4993	6330-6343	GO:0005739	denotes	mitochondrial
T4994	6397-6417	UBERON:0001388	denotes	gastrocnemius muscle
T4995	6432-6441	SO_EXT:wild_type_entity_or_quality	denotes	Wild-type
T4996	6448-6452	NCBITaxon:10088	denotes	mice
T4997	6482-6487	PR_EXT:000013057	denotes	PPARδ
T4998	6482-6495	CHEBI_EXT:73730	denotes	PPARδ agonist
T4999	6488-6495	CHEBI_GO_EXT:agonist	denotes	agonist
T5000	6496-6504	CHEBI:73726	denotes	GW501516
T5001	6521-6524	CHEBI_SO_EXT:RNA	denotes	RNA
T5002	6556-6576	UBERON:0001388	denotes	gastrocnemius muscle
T5003	6603-6609	CHEBI_SO_EXT:molecular_probe	denotes	probes
T4880	5250-5259	MOP:0000568	denotes	Oxidative
T4881	5250-5273	CL:0002211	denotes	Oxidative Type I Fibers
T4637	651-661	GO:0010467	denotes	Expression
T1137	1777-1782	PR_EXT:000013057	denotes	PPARδ
T1138	1790-1797	GO:0065007	denotes	control
T1139	1810-1811	CHEBI_SO_EXT:base	denotes	b
T1140	1812-1817	NCBITaxon:9606	denotes	human
T1141	1818-1834	PR_EXT:000003674	denotes	α-skeletal actin
T1142	1820-1828	UBERON:0004288	denotes	skeletal
T1143	1835-1843	SO_EXT:0000167	denotes	promoter
T1144	1901-1909	SO_EXT:0000167	denotes	promoter
T1145	1964-1968	PR_EXT:P06492	denotes	VP16
T1146	1969-1974	PR_EXT:000013057	denotes	PPARδ
T1147	1975-1984	SO_EXT:0000902	denotes	transgene
T1148	2001-2010	GO:0010467	denotes	expressed
T1169	2567-2579	CL:0002211	denotes	type I fiber
T1170	2613-2622	GO:0010467	denotes	expresses
T1171	2640-2645	PR_EXT:000013057	denotes	PPARδ
T1172	2666-2672	CL:0002211	denotes	Type I
T1116	405-411	CL:0002211	denotes	type I
T1117	416-423	CL:0002212	denotes	type II
T1118	430-436	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1119	438-451	UBERON:0001388	denotes	gastrocnemius
T1120	471-481	GO:0010467	denotes	expression
T1121	516-522	PR_EXT:000013059	denotes	PGC-1α
T1122	614-621	CHEBI_PR_EXT:protein	denotes	protein
T1123	1569-1574	PR_EXT:000013057	denotes	PPARδ
T1124	1578-1585	GO:0065007	denotes	control
T1125	1589-1595	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1126	1589-1601	CL:0000187	denotes	muscle fiber
T1127	1617-1630	GO:0005739	denotes	mitochondrial
T1128	1631-1641	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T1129	1656-1660	NCBITaxon:10088	denotes	mice
T1130	1661-1671	GO:0010467	denotes	expressing
T1131	1674-1683	SO_EXT:0000902	denotes	transgene
T1132	1700-1710	CHEBI_SO_EXT:amino_acid	denotes	amino-acid
T1133	1711-1715	PR_EXT:P06492	denotes	VP16
T1134	1727-1733	SO_EXT:0000417	denotes	domain
T1135	1738-1743	SO_EXT:sequence_fusion_process	denotes	fused
T1136	1751-1761	CHEBI_SO_EXT:N_terminus_or_N_terminal_region	denotes	N-terminus
T1149	2014-2029	UBERON_EXT:skeletal_muscle_organ_or_tissue	denotes	skeletal muscle
T1150	2056-2061	UBERON:0000948	denotes	heart
T1151	2100-2106	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1152	2100-2113	CL:0000187	denotes	muscle fibers
T1153	2129-2133	PR_EXT:P06492	denotes	VP16
T1154	2134-2139	PR_EXT:000013057	denotes	PPARδ
T1155	2140-2150	GO:0010467	denotes	expression
T1156	2220-2240	UBERON:0001388	denotes	gastrocnemius muscle
T1157	2242-2246	PR_EXT:P06492	denotes	VP16
T1158	2247-2252	PR_EXT:000013057	denotes	PPARδ
T1159	2253-2259	SO_EXT:sequence_fusion_entity_or_process	denotes	fusion
T1160	2260-2267	CHEBI_PR_EXT:protein	denotes	protein
T1161	2322-2327	PR_EXT:000013057	denotes	PPARδ
T1162	2331-2340	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T1163	2393-2399	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1164	2400-2405	PR_EXT:000013057	denotes	PPARδ
T1165	2406-2413	CHEBI_PR_EXT:protein	denotes	protein
T1166	2421-2431	SO_EXT:transgenic_entity	denotes	transgenic
T1167	2432-2436	NCBITaxon:10088	denotes	mice
T1168	2525-2530	PR_EXT:000013057	denotes	PPARδ
T1173	2673-2679	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1174	2714-2721	CL:0002212	denotes	type II
T1175	2731-2737	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1176	2793-2802	CHEBI_PR_EXT:myoglobin	denotes	myoglobin
T1177	2806-2813	CHEBI_PR_EXT:protein	denotes	protein
T1178	2824-2833	GO:0010467	denotes	expressed
T1179	2837-2846	MOP:0000568	denotes	oxidative
T1180	2837-2860	CL:0002210	denotes	oxidative muscle fibers
T1181	2847-2853	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1182	2876-2883	UBERON:0005090	denotes	muscles
T1183	2891-2901	SO_EXT:transgenic_entity	denotes	transgenic
T1184	2902-2906	NCBITaxon:10088	denotes	mice
T1185	2979-2985	_FRAGMENT	denotes	type I
T1186	2989-2995	CL:0002211	denotes	fibers
T1187	2979-2983	_FRAGMENT	denotes	type
T1224	3866-3870	SO_EXT:sequence_copy_entity	denotes	copy
T1225	3885-3898	GO:0005739	denotes	mitochondrial
T1226	3899-3905	SO_EXT:0001026	denotes	genome
T1227	3906-3913	SO_EXT:sequence_coding_function	denotes	encoded
T1228	3914-3919	PR_EXT:000025365	denotes	COXII
T1229	3920-3923	CHEBI_SO_EXT:DNA	denotes	DNA
T1230	3931-3941	SO_EXT:transgenic_entity	denotes	transgenic
T1231	3942-3946	NCBITaxon:10088	denotes	mice
T1232	3960-3973	GO:0005739	denotes	Mitochondrial
T1233	3960-3977	SO:0001032	denotes	Mitochondrial DNA
T1234	3974-3977	CHEBI_SO_EXT:DNA	denotes	DNA
T1235	4004-4024	UBERON:0001388	denotes	gastrocnemius muscle
T1236	4032-4042	SO_EXT:transgenic_entity	denotes	transgenic
T1237	4043-4047	NCBITaxon:10088	denotes	mice
T1238	4106-4119	GO:0005739	denotes	mitochondrial
T1239	4120-4130	GO_EXT:biogenesis_or_biosynthesis	denotes	biogenesis
T1240	4176-4182	UBERON_EXT:muscle_structure_or_tissue	denotes	muscle
T1241	4176-4188	CL:0000187	denotes	muscle fiber
T1242	4300-4312	CL:0002211	denotes	type I fiber
T1243	4313-4321	CHEBI_PR_EXT:protein	denotes	proteins
T1244	4331-4340	CHEBI_PR_EXT:myoglobin	denotes	myoglobin
T1245	4345-4357	PR_EXT:000002199	denotes	cytochrome c
T1246	4345-4357	CHEBI:18070	denotes	cytochrome c
T1247	4345-4355	_FRAGMENT	denotes	cytochrome
T1248	4362-4363	PR_EXT:000010690	denotes	b
T1249	4362-4363	CHEBI:38551	denotes	b
T1250	4429-4440	GO:0006936	denotes	contraction
T1251	4441-4448	CHEBI_PR_EXT:protein	denotes	protein
T1252	4449-4466	PR_EXT:000016504	denotes	troponin I (slow)
T1253	4470-4482	CL:0002211	denotes	type I fiber
T1254	4567-4578	GO:0006936	denotes	contraction
T1255	4579-4586	CHEBI_PR_EXT:protein	denotes	protein
T1256	4587-4604	PR_EXT:000016505	denotes	troponin I (fast)
T1257	4608-4621	CL:0002212	denotes	type II fiber
T1258	4729-4734	PR_EXT:000013057	denotes	PPARδ
T1259	4763-4768	SO_EXT:0000704	denotes	genes
T1260	4815-4825	SO_EXT:transgenic_entity	denotes	transgenic
T1261	4826-4830	NCBITaxon:10088	denotes	mice
T1262	4866-4875	SO_EXT:wild_type_entity_or_quality	denotes	wild-type
T1263	4883-4887	NCBITaxon:10088	denotes	mice
T1264	4897-4902	PR_EXT:000013057	denotes	PPARδ
R715	T1186	T1185	_lexicallyChainedTo	fibers,type I
R716	T1188	T1187	_lexicallyChainedTo	II fibers,type
R717	T1209	T1208	_lexicallyChainedTo	II,cytochrome c oxidase
R718	T1209	T1212	_lexicallyChainedTo	II,COX
R719	T1210	T1208	_lexicallyChainedTo	IV,cytochrome c oxidase
R720	T1210	T1212	_lexicallyChainedTo	IV,COX
R721	T1248	T1247	_lexicallyChainedTo	b,cytochrome
R722	T1249	T1247	_lexicallyChainedTo	b,cytochrome

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T973	14-19	PR:000013057	denotes	PPARδ
T974	29-41	CL:0000187	denotes	Muscle Fiber
T975	67-72	PR:000013057	denotes	PPARδ
T976	76-88	CL:0000187	denotes	muscle fiber
T977	119-129	GO:0010467	denotes	expression
T978	173-178	PR:000013056	denotes	PPARα
T979	185-193	SO:0001060	denotes	isoforms
T980	246-251	PR:000013057	denotes	PPARδ
T981	265-278	CL:0000187	denotes	muscle fibers
T982	319-325	CL:0002211	denotes	type I
T983	334-340	UBERON:0001389	denotes	soleus
T984	354-361	CL:0002212	denotes	type II
T985	375-400	UBERON:0001386	denotes	extensor digitorum longus
T986	405-411	CL:0002211	denotes	type I
T987	416-423	CL:0002212	denotes	type II
T988	438-451	UBERON:0001388	denotes	gastrocnemius
T989	471-481	GO:0010467	denotes	expression
T990	516-522	PR:000013059	denotes	PGC-1α
T991	1569-1574	PR:000013057	denotes	PPARδ
T992	1578-1585	GO:0065007	denotes	control
T993	1589-1601	CL:0000187	denotes	muscle fiber
T994	1617-1630	GO:0005739	denotes	mitochondrial
T995	1656-1660	NCBITaxon:10088	denotes	mice
T996	1661-1671	GO:0010467	denotes	expressing
T997	1674-1683	SO:0000902	denotes	transgene
T998	1711-1715	PR:P06492	denotes	VP16
T999	1727-1733	SO:0000417	denotes	domain
T1000	1777-1782	PR:000013057	denotes	PPARδ
T1001	1790-1797	GO:0065007	denotes	control
T1002	1812-1817	NCBITaxon:9606	denotes	human
T1003	1818-1834	PR:000003674	denotes	α-skeletal actin
T1004	1820-1828	UBERON:0004288	denotes	skeletal
T1005	1835-1843	SO:0000167	denotes	promoter
T1006	1901-1909	SO:0000167	denotes	promoter
T1007	1964-1968	PR:P06492	denotes	VP16
T1008	1969-1974	PR:000013057	denotes	PPARδ
T1009	1975-1984	SO:0000902	denotes	transgene
T1010	2001-2010	GO:0010467	denotes	expressed
T1011	2014-2022	UBERON:0004288	denotes	skeletal
T1012	2056-2061	UBERON:0000948	denotes	heart
T1013	2100-2113	CL:0000187	denotes	muscle fibers
T1014	2129-2133	PR:P06492	denotes	VP16
T1015	2134-2139	PR:000013057	denotes	PPARδ
T1016	2140-2150	GO:0010467	denotes	expression
T1017	2220-2240	UBERON:0001388	denotes	gastrocnemius muscle
T1018	2242-2246	PR:P06492	denotes	VP16
T1019	2247-2252	PR:000013057	denotes	PPARδ
T1020	2322-2327	PR:000013057	denotes	PPARδ
T1021	2400-2405	PR:000013057	denotes	PPARδ
T1022	2432-2436	NCBITaxon:10088	denotes	mice
T1023	2525-2530	PR:000013057	denotes	PPARδ
T1024	2567-2579	CL:0002211	denotes	type I fiber
T1025	2613-2622	GO:0010467	denotes	expresses
T1026	2640-2645	PR:000013057	denotes	PPARδ
T1027	2666-2672	CL:0002211	denotes	Type I
T1028	2714-2721	CL:0002212	denotes	type II
T1029	2824-2833	GO:0010467	denotes	expressed
T1030	2837-2846	MOP:0000568	denotes	oxidative
T1031	2837-2860	CL:0002210	denotes	oxidative muscle fibers
T1032	2876-2883	UBERON:0005090	denotes	muscles
T1033	2902-2906	NCBITaxon:10088	denotes	mice
T1034	2979-2985	_FRAGMENT	denotes	type I
T1035	2989-2995	CL:0002211	denotes	fibers
T1036	2979-2983	_FRAGMENT	denotes	type
T1037	2986-2995	CL:0002212	denotes	II fibers
T1038	3003-3011	UBERON:0002103	denotes	hindlimb
T1039	3079-3091	CL:0000187	denotes	muscle fiber
T1040	3123-3143	UBERON:0001388	denotes	gastrocnemius muscle
T1041	3194-3207	CL:0002211	denotes	type I fibers
T1042	3235-3244	MOP:0000568	denotes	oxidative
T1043	3235-3251	CL:0002210	denotes	oxidative fibers
T1044	3280-3293	GO:0005739	denotes	mitochondrial
T1045	3389-3402	GO:0005739	denotes	mitochondrial
T1046	3418-3426	CHEBI:10545	denotes	electron
T1047	3418-3435	MOP:0000615	denotes	electron transfer
T1048	3437-3449	PR:000002199	denotes	cytochrome c
T1049	3437-3449	CHEBI:18070	denotes	cytochrome c
T1050	3454-3466	CHEBI:18070	denotes	cytochrome c
T1051	3454-3474	_FRAGMENT	denotes	cytochrome c oxidase
T1052	3481-3483	PR:000025365	denotes	II
T1053	3488-3490	PR:000005776	denotes	IV
T1054	3476-3479	_FRAGMENT	denotes	COX
T1055	3496-3506	CHEBI:35366	denotes	fatty-acid
T1056	3496-3518	GO:0006635	denotes	fatty-acid β-oxidation
T1057	3509-3518	MOP:0000568	denotes	oxidation
T1058	3622-3627	PR:000013057	denotes	PPARδ
T1059	3653-3659	PR:000013059	denotes	PGC-1α
T1060	3687-3699	CL:0000187	denotes	muscle fiber
T1061	3711-3724	GO:0005739	denotes	mitochondrial
T1062	3885-3898	GO:0005739	denotes	mitochondrial
T1063	3899-3905	SO:0001026	denotes	genome
T1064	3914-3919	PR:000025365	denotes	COXII
T1065	3942-3946	NCBITaxon:10088	denotes	mice
T1066	3960-3973	GO:0005739	denotes	Mitochondrial
T1067	3960-3977	SO:0001032	denotes	Mitochondrial DNA
T1068	4004-4024	UBERON:0001388	denotes	gastrocnemius muscle
T1069	4043-4047	NCBITaxon:10088	denotes	mice
T1070	4106-4119	GO:0005739	denotes	mitochondrial
T1071	4176-4188	CL:0000187	denotes	muscle fiber
T1072	4300-4312	CL:0002211	denotes	type I fiber
T1073	4345-4357	PR:000002199	denotes	cytochrome c
T1074	4345-4357	CHEBI:18070	denotes	cytochrome c
T1075	4345-4355	_FRAGMENT	denotes	cytochrome
T1076	4362-4363	PR:000010690	denotes	b
T1077	4362-4363	CHEBI:38551	denotes	b
T1078	4429-4440	GO:0006936	denotes	contraction
T1079	4449-4466	PR:000016504	denotes	troponin I (slow)
T1080	4470-4482	CL:0002211	denotes	type I fiber
T1081	4567-4578	GO:0006936	denotes	contraction
T1082	4587-4604	PR:000016505	denotes	troponin I (fast)
T1083	4608-4621	CL:0002212	denotes	type II fiber
T1084	4729-4734	PR:000013057	denotes	PPARδ
T1085	4763-4768	SO:0000704	denotes	genes
T1086	4826-4830	NCBITaxon:10088	denotes	mice
T1087	4883-4887	NCBITaxon:10088	denotes	mice
T1088	4897-4902	PR:000013057	denotes	PPARδ
T1089	4920-4928	CHEBI:73726	denotes	GW501516
T1090	4944-4949	SO:0000704	denotes	genes
T1091	4954-4964	CL:0000189	denotes	slow fiber
T1092	4965-4976	GO:0006936	denotes	contractile
T1093	4987-5000	GO:0005739	denotes	mitochondrial
T1094	5019-5028	MOP:0000568	denotes	oxidation
T1095	5129-5141	CL:0000187	denotes	muscle fiber
T1096	5160-5166	CL:0002211	denotes	type I
T1097	5215-5220	PR:000013057	denotes	PPARδ
T4606	651-661	GO:0010467	denotes	Expression
T4607	676-681	PR:000013057	denotes	PPARδ
T4608	686-690	PR:P06492	denotes	VP16
T4609	691-696	PR:000013057	denotes	PPARδ
T4610	697-706	SO:0000902	denotes	Transgene
T4611	754-761	UBERON:0005090	denotes	muscles
T4612	791-795	NCBITaxon:10088	denotes	mice
T4613	800-810	GO:0097617	denotes	hybridized
T4614	834-837	UBERON:0001386	denotes	EDL
T4615	839-864	UBERON:0001386	denotes	extensor digitorum longus
T4616	866-872	UBERON:0001388	denotes	Gastro
T4617	874-887	UBERON:0001388	denotes	gastrocnemius
T4618	900-907	GO:0005634	denotes	nuclear
T4619	944-951	UBERON:0005090	denotes	muscles
T4620	1003-1008	PR:000013057	denotes	PPARδ
T4621	1009-1017	GO:0042571	denotes	antibody
T4622	1081-1091	GO:0010467	denotes	Expression
T4623	1099-1103	PR:P06492	denotes	VP16
T4624	1104-1109	PR:000013057	denotes	PPARδ
T4625	1110-1119	SO:0000902	denotes	transgene
T4626	1131-1138	UBERON:0000479	denotes	tissues
T4627	1169-1175	UBERON:0000479	denotes	tissue
T4628	1180-1190	GO:0097617	denotes	hybridized
T4629	1198-1202	PR:P06492	denotes	VP16
T4630	1215-1235	UBERON:0001388	denotes	Gastrocnemius muscle
T4631	1255-1262	GO:0005634	denotes	Nuclear
T4632	1299-1319	UBERON:0001388	denotes	gastrocnemius muscle
T4633	1338-1342	NCBITaxon:10088	denotes	mice
T4634	1410-1420	GO:0042571	denotes	antibodies
T4635	1483-1488	PR:000013057	denotes	PPARδ
T4636	1489-1497	GO:0042571	denotes	antibody
T4871	5250-5259	MOP:0000568	denotes	Oxidative
T4872	5250-5273	CL:0002211	denotes	Oxidative Type I Fibers
T4873	5292-5296	NCBITaxon:10088	denotes	Mice
T4874	5307-5314	UBERON:0005090	denotes	Muscles
T4875	5329-5333	NCBITaxon:10088	denotes	mice
T4876	5374-5378	NCBITaxon:10088	denotes	mice
T4877	5419-5426	CL:0002212	denotes	type II
T4878	5427-5443	UBERON:0011905	denotes	plantaris muscle
T4879	5445-5458	CL:0002211	denotes	Type I fibers
T5004	5506-5511	PR:000013057	denotes	PPARδ
T5005	5520-5525	SO:0000704	denotes	Genes
T5006	5538-5551	CL:0002211	denotes	Type I Fibers
T5007	5565-5578	GO:0005739	denotes	Mitochondrial
T5008	5631-5651	UBERON:0001388	denotes	gastrocnemius muscle
T5009	5775-5779	SO:0000704	denotes	gene
T5010	5800-5807	SO:0001026	denotes	genomic
T5011	5839-5859	UBERON:0001388	denotes	gastrocnemius muscle
T5012	5923-5928	PR:000025365	denotes	COXII
T5013	5930-5943	GO:0005739	denotes	mitochondrial
T5014	5944-5950	SO:0001026	denotes	genome
T5015	5964-5969	PR:000013829	denotes	MCIP1
T5016	5971-5978	GO:0005634	denotes	nuclear
T5017	5979-5985	SO:0001026	denotes	genome
T5018	6028-6048	UBERON:0001388	denotes	gastrocnemius muscle
T5019	6085-6089	NCBITaxon:10088	denotes	mice
T5020	6121-6134	GO:0005739	denotes	mitochondrial
T5021	6121-6138	SO:0001032	denotes	mitochondrial DNA
T5022	6172-6179	CHEBI:2511	denotes	agarose
T5023	6211-6224	GO:0005739	denotes	mitochondrial
T5024	6211-6228	SO:0001032	denotes	mitochondrial DNA
T5025	6257-6261	NCBITaxon:10088	denotes	mice
T5026	6305-6317	CL:0000187	denotes	muscle fiber
T5027	6330-6343	GO:0005739	denotes	mitochondrial
T5028	6397-6417	UBERON:0001388	denotes	gastrocnemius muscle
T5029	6448-6452	NCBITaxon:10088	denotes	mice
T5030	6482-6487	PR:000013057	denotes	PPARδ
T5031	6482-6495	CHEBI:73730	denotes	PPARδ agonist
T5032	6496-6504	CHEBI:73726	denotes	GW501516
T5033	6556-6576	UBERON:0001388	denotes	gastrocnemius muscle
R707	T1035	T1034	_lexicallyChainedTo	fibers,type I
R708	T1037	T1036	_lexicallyChainedTo	II fibers,type
R709	T1052	T1051	_lexicallyChainedTo	II,cytochrome c oxidase
R710	T1052	T1054	_lexicallyChainedTo	II,COX
R711	T1053	T1051	_lexicallyChainedTo	IV,cytochrome c oxidase
R712	T1053	T1054	_lexicallyChainedTo	IV,COX
R713	T1076	T1075	_lexicallyChainedTo	b,cytochrome
R714	T1077	T1075	_lexicallyChainedTo	b,cytochrome

PMC:509410 / 4242-10852 JSONTXT

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