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transactivation domain (78 amino acid residues, corresponding to residues 413–490) of VP16 was fused in frame with the N-terminus of mouse PPARδ. The VP16-PPARδ fusion cDNA was placed downstream of the human α-skeletal actin promoter (Brennan and Hardeman 1993), and upstream of the SV40 intron/poly(A) sequence. The transgene was purified and injected into C57BL/6J × CBA F1 zygotes. Transgenic mice were backcrossed with C57BL/6J for two generations. Wild-type littermates were used as controls throughout the study. On normal chow diet, the transgenic mice and control littermates used here had similar body weights. PPARδ-null mice were previously generated (Barak et al. 2002). Mice were fed either a standard chow with 4% (w/w) fat content (Harlan Teklad, Harlan, Indianapolis, Indiana, United States) or a high-fat diet containing 35% (w/w) fat content (product F3282, Bioserv, Frenchtown, New Jersey, United States) as indicated. For ligand experiments, we synthesized the GW501516 compound and mice were orally gavaged daily (10 mg/kg or vehicle alone)."}

{"project":"2_test","denotations":[{"id":"15328533-7678010-84708293","span":{"begin":260,"end":264},"obj":"7678010"},{"id":"15328533-11756685-84708294","span":{"begin":680,"end":684},"obj":"11756685"},{"id":"T7615","span":{"begin":260,"end":264},"obj":"7678010"},{"id":"T79960","span":{"begin":680,"end":684},"obj":"11756685"}],"text":"The transactivation domain (78 amino acid residues, corresponding to residues 413–490) of VP16 was fused in frame with the N-terminus of mouse PPARδ. The VP16-PPARδ fusion cDNA was placed downstream of the human α-skeletal actin promoter (Brennan and Hardeman 1993), and upstream of the SV40 intron/poly(A) sequence. The transgene was purified and injected into C57BL/6J × CBA F1 zygotes. Transgenic mice were backcrossed with C57BL/6J for two generations. Wild-type littermates were used as controls throughout the study. On normal chow diet, the transgenic mice and control littermates used here had similar body weights. PPARδ-null mice were previously generated (Barak et al. 2002). Mice were fed either a standard chow with 4% (w/w) fat content (Harlan Teklad, Harlan, Indianapolis, Indiana, United States) or a high-fat diet containing 35% (w/w) fat content (product F3282, Bioserv, Frenchtown, New Jersey, United States) as indicated. For ligand experiments, we synthesized the GW501516 compound and mice were orally gavaged daily (10 mg/kg or vehicle alone)."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T3998","span":{"begin":20,"end":26},"obj":"SO:0000417"},{"id":"T3999","span":{"begin":90,"end":94},"obj":"PR:P06492"},{"id":"T4000","span":{"begin":105,"end":113},"obj":"SO:0001817"},{"id":"T4001","span":{"begin":137,"end":142},"obj":"NCBITaxon:10088"},{"id":"T4002","span":{"begin":143,"end":148},"obj":"PR:000013057"},{"id":"T4003","span":{"begin":154,"end":158},"obj":"PR:P06492"},{"id":"T4004","span":{"begin":159,"end":164},"obj":"PR:000013057"},{"id":"T4005","span":{"begin":206,"end":211},"obj":"NCBITaxon:9606"},{"id":"T4006","span":{"begin":212,"end":228},"obj":"PR:000003674"},{"id":"T4007","span":{"begin":214,"end":222},"obj":"UBERON:0004288"},{"id":"T4008","span":{"begin":229,"end":237},"obj":"SO:0000167"},{"id":"T4009","span":{"begin":287,"end":291},"obj":"NCBITaxon:10633"},{"id":"T4010","span":{"begin":292,"end":298},"obj":"SO:0000188"},{"id":"T4011","span":{"begin":299,"end":315},"obj":"SO:0000610"},{"id":"T4012","span":{"begin":321,"end":330},"obj":"SO:0000902"},{"id":"T4013","span":{"begin":380,"end":387},"obj":"CL:0000365"},{"id":"T4014","span":{"begin":400,"end":404},"obj":"NCBITaxon:10088"},{"id":"T4015","span":{"begin":533,"end":537},"obj":"CHEBI:33290"},{"id":"T4016","span":{"begin":559,"end":563},"obj":"NCBITaxon:10088"},{"id":"T4017","span":{"begin":624,"end":629},"obj":"PR:000013057"},{"id":"T4018","span":{"begin":635,"end":639},"obj":"NCBITaxon:10088"},{"id":"T4019","span":{"begin":687,"end":691},"obj":"NCBITaxon:10088"},{"id":"T4020","span":{"begin":697,"end":700},"obj":"GO:0007631"},{"id":"T4021","span":{"begin":719,"end":723},"obj":"CHEBI:33290"},{"id":"T4022","span":{"begin":985,"end":993},"obj":"CHEBI:73726"},{"id":"T4023","span":{"begin":994,"end":1002},"obj":"CHEBI:36357"},{"id":"T4024","span":{"begin":1007,"end":1011},"obj":"NCBITaxon:10088"}],"text":"The transactivation domain (78 amino acid residues, corresponding to residues 413–490) of VP16 was fused in frame with the N-terminus of mouse PPARδ. The VP16-PPARδ fusion cDNA was placed downstream of the human α-skeletal actin promoter (Brennan and Hardeman 1993), and upstream of the SV40 intron/poly(A) sequence. The transgene was purified and injected into C57BL/6J × CBA F1 zygotes. Transgenic mice were backcrossed with C57BL/6J for two generations. Wild-type littermates were used as controls throughout the study. On normal chow diet, the transgenic mice and control littermates used here had similar body weights. PPARδ-null mice were previously generated (Barak et al. 2002). Mice were fed either a standard chow with 4% (w/w) fat content (Harlan Teklad, Harlan, Indianapolis, Indiana, United States) or a high-fat diet containing 35% (w/w) fat content (product F3282, Bioserv, Frenchtown, New Jersey, United States) as indicated. For ligand experiments, we synthesized the GW501516 compound and mice were orally gavaged daily (10 mg/kg or vehicle alone)."}