PMC:509305 / 39478-40756 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/509305","sourcedb":"PMC","sourceid":"509305","source_url":"http://www.ncbi.nlm.nih.gov/pmc/509305","text":"We are grateful to M. Lewis for the processing of the samples for histology and to F. Reid and D. Mitchell for their help. We thank all of the staff in the animal facility for their technical assistance. This work was supported by the Wellcome Trust (grant number 061438). JCH was a recipient of a fellowship from the National Institute of Health, Spain (BEFI 99/9212). Conflicts of interest. The authors have declared that no conflicts of interest exist.\nAuthor contributions. MJW, TJV, and MB conceived and designed the experiments. AEB, KLR, JW, JC-H, and RJR performed the experiments. AEB, KLR, RJR, and HTC analyzed the data. MB wrote the paper.\nAcademic Editor: David Nemazee, Scripps Research Institute\n¤ Current address: The Wellcome Trust, London, United Kingdom\nCitation: Bygrave AE, Rose KL, Cortes-Hernandez J, Warren J, Rigby RJ, et al. (2004) Spontaneous autoimmunity in 129 and C57BL/6 mice—Implications for autoimmunity described in gene-targeted mice. PLoS Biol 2(8): e243.\nAbbreviations\nAb antibody\nANA anti-nuclear antibody\nAEU arbitrary ELISA unit\nApcs −/− Apcs-deficient mice\nApcs serum amyloid P component gene\ndsDNA double-stranded DNA\nLOD logarithm of odds\nQTL quantitative trait linkage\nSLE systemic lupus erythematosus\nssDNA anti-single-stranded DNA","divisions":[{"label":"ack","span":{"begin":0,"end":369}},{"label":"p","span":{"begin":0,"end":369}},{"label":"footnote","span":{"begin":370,"end":456}},{"label":"p","span":{"begin":370,"end":456}},{"label":"footnote","span":{"begin":456,"end":652}},{"label":"p","span":{"begin":456,"end":652}},{"label":"footnote","span":{"begin":652,"end":710}},{"label":"p","span":{"begin":652,"end":710}},{"label":"footnote","span":{"begin":711,"end":772}},{"label":"p","span":{"begin":711,"end":772}},{"label":"footnote","span":{"begin":773,"end":991}},{"label":"p","span":{"begin":773,"end":991}},{"label":"title","span":{"begin":992,"end":1005}},{"label":"p","span":{"begin":1009,"end":1017}},{"label":"p","span":{"begin":1022,"end":1043}},{"label":"p","span":{"begin":1048,"end":1068}},{"label":"p","span":{"begin":1080,"end":1099}},{"label":"p","span":{"begin":1106,"end":1136}},{"label":"p","span":{"begin":1142,"end":1161}},{"label":"p","span":{"begin":1166,"end":1183}},{"label":"p","span":{"begin":1188,"end":1214}},{"label":"p","span":{"begin":1219,"end":1247}}],"tracks":[]}