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PMC:509305 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T18802 38013-38016 CHEBI:8984 denotes SDS
T18801 37994-38001 CHEBI:2511 denotes agarose
T18800 37969-37985 CHEBI:4883 denotes ethidium bromide
T18799 37930-37937 SO:0000112 denotes primers
T18798 37919-37923 NCBITaxon:10088 denotes mice
T18797 37826-37833 SO:0000112 denotes primers
T18796 37809-37814 CHEBI:6636 denotes MgCl2
T18795 37782-37790 CHEBI:33893 denotes reagents
T18794 37736-37745 GO:0030849 denotes autosomes
T18793 37636-37643 SO:0001026 denotes genomic
T17664 36352-36357 UBERON:0001977 denotes serum
T17663 36346-36351 NCBITaxon:10088 denotes mouse
T17662 36337-36341 PR:000004126 denotes Apcs
T17661 36318-36322 PR:000004126 denotes Apcs
T17660 36282-36287 UBERON:0001977 denotes serum
T17659 36270-36281 GO:0006953 denotes acute-phase
T17658 36077-36080 GO:0042571 denotes Abs
T17657 36072-36076 PR:000004126 denotes Apcs
T17656 36066-36071 NCBITaxon:10088 denotes mouse
T17655 36054-36060 NCBITaxon:9986 denotes rabbit
T17654 36045-36049 PR:000004126 denotes Apcs
T17653 36039-36044 NCBITaxon:10088 denotes mouse
T17652 36028-36033 NCBITaxon:9940 denotes sheep
T17651 35987-35991 PR:000004126 denotes Apcs
T17650 35945-35950 UBERON:0001977 denotes serum
T17649 35836-35841 NCBITaxon:10088 denotes mouse
T17648 35577-35586 GO:0000785 denotes chromatin
T17647 35555-35558 GO:0042571 denotes Abs
T17646 35434-35439 UBERON:0001977 denotes Serum
T17645 35367-35385 NCBITaxon:46909 denotes Crithidia luciliae
T17644 35315-35318 GO:0042571 denotes Abs
T17643 35230-35233 GO:0071735 denotes IgG
T17642 35215-35218 GO:0042571 denotes Abs
T17641 35138-35142 UBERON:0001977 denotes Sera
T16603 35047-35053 NCBITaxon:33208 denotes animal
T16602 34981-34988 NCBITaxon:33208 denotes Animals
T16601 34941-34945 NCBITaxon:10088 denotes mice
T16600 34896-34903 NCBITaxon:33208 denotes animals
T16599 34866-34870 NCBITaxon:10088 denotes mice
T16598 34858-34862 PR:000004126 denotes Apcs
T16597 34572-34576 PR:000004126 denotes Apcs
T16596 34554-34560 SO:0001026 denotes genome
T16595 34493-34497 NCBITaxon:10088 denotes mice
T16594 34484-34488 PR:000004126 denotes Apcs
T16593 34229-34233 NCBITaxon:10088 denotes mice
T16592 34096-34100 NCBITaxon:10088 denotes mice
T13231 29451-29455 PR:000004126 denotes Apcs
T13230 29369-29372 GO:0042571 denotes Abs
T13229 29260-29271 SO:0000704 denotes genetically
T13228 29238-29242 NCBITaxon:10088 denotes mice
T13227 29229-29233 PR:000004126 denotes Apcs
T13226 29128-29130 GO:0042571 denotes Ab
T13225 29118-29127 GO:0000785 denotes chromatin
T13224 29047-29051 SO:0000704 denotes gene
T13223 29042-29046 PR:000004126 denotes Apcs
T13222 28984-28990 SO:0001026 denotes genome
T13221 28783-28787 NCBITaxon:10088 denotes mice
T13220 28774-28778 PR:000004126 denotes Apcs
T13219 28695-28699 NCBITaxon:10088 denotes mice
T13218 28686-28690 PR:000004126 denotes Apcs
T13217 28622-28624 GO:0042571 denotes Ab
T13216 28612-28621 GO:0000785 denotes chromatin
T13215 28506-28515 GO:0000785 denotes chromatin
T13214 28471-28475 PR:000004126 denotes Apcs
T13213 28358-28365 GO:0032991 denotes complex
T13212 28351-28357 UBERON:0002405 denotes immune
T13211 28279-28283 NCBITaxon:10088 denotes mice
T13210 28270-28274 PR:000004126 denotes Apcs
T13209 28128-28143 CL:0000445 denotes apoptotic cells
T13208 28114-28123 GO:0000785 denotes chromatin
T13207 27985-28000 CL:0000445 denotes apoptotic cells
T13206 27970-27979 GO:0000785 denotes chromatin
T13205 27929-27936 CHEBI:60425 denotes amyloid
T13204 27923-27948 PR:000004126 denotes serum amyloid P component
T13203 27923-27928 UBERON:0001977 denotes serum
T13202 27917-27922 NCBITaxon:9606 denotes human
T13201 27874-27879 SO:0000704 denotes genes
T13191 27291-27302 SO:0000704 denotes genetically
T13190 27268-27272 NCBITaxon:10088 denotes mice
T13189 27259-27263 PR:000004126 denotes Apcs
T13188 27217-27224 NCBITaxon:33208 denotes animals
T13187 27203-27207 SO:0000704 denotes gene
T13186 27104-27108 NCBITaxon:10088 denotes mice
T13185 27058-27063 SO:0000704 denotes genes
T13184 27036-27041 NCBITaxon:10088 denotes mouse
T13183 26968-26974 SO:0001026 denotes genome
T13182 26904-26911 SO:0000704 denotes genetic
T13181 26720-26726 NCBITaxon:39107 denotes murine
T13180 26403-26410 SO:0001023 denotes alleles
T13179 26241-26246 SO:0000704 denotes genes
T13178 26133-26138 SO:0000704 denotes genes
T13177 26059-26067 CHEBI:59132 denotes antigens
T13176 26051-26058 GO:0005634 denotes nuclear
T13175 26032-26038 UBERON:0002405 denotes immune
T13174 25952-25955 GO:0042571 denotes Abs
T13173 25933-25943 GO:0010467 denotes expression
T13172 25841-25845 NCBITaxon:10088 denotes mice
T13171 25752-25759 SO:0000704 denotes genetic
T13170 25597-25604 SO:0001023 denotes alleles
T13169 25518-25522 NCBITaxon:10088 denotes mice
T13168 25176-25180 NCBITaxon:10088 denotes mice
T13167 25162-25166 SO:0000704 denotes gene
T13166 25140-25147 SO:0000704 denotes genetic
T13165 25049-25056 SO:0000704 denotes genetic
T13164 24804-24811 SO:0001023 denotes alleles
T13163 24611-24617 NCBITaxon:39107 denotes murine
T13162 24479-24486 SO:0001023 denotes alleles
T13161 24302-24306 NCBITaxon:10088 denotes mice
T13160 24288-24292 SO:0000704 denotes gene
T13159 24208-24215 SO:0000704 denotes genetic
T13158 24128-24134 UBERON:0002405 denotes immune
T13157 24099-24103 SO:0000704 denotes gene
T13156 23988-23991 GO:0042571 denotes Abs
T13155 23919-23923 SO:0000704 denotes gene
T13154 23895-23907 GO:0000806 denotes Y-chromosome
T13153 23846-23848 GO:0042571 denotes Ab
T13152 23769-23773 SO:0000704 denotes gene
T13151 23636-23638 GO:0042571 denotes Ab
T13150 23565-23569 SO:0000704 denotes gene
T13149 23535-23539 NCBITaxon:10088 denotes mice
T13148 23518-23523 SO:0000704 denotes genes
T13147 23422-23428 UBERON:0002405 denotes immune
T13146 23378-23383 SO:0000704 denotes genes
T13145 23344-23348 SO:0000704 denotes gene
T13144 23299-23308 GO:0010467 denotes expressed
T13143 23293-23298 SO:0000704 denotes genes
T13142 23267-23271 SO:0000704 denotes gene
T13141 23246-23250 SO:0000704 denotes gene
T13140 23211-23218 GO:0005634 denotes nuclear
T13139 23070-23077 SO:0000704 denotes genetic
T13138 23016-23036 CL:0002322 denotes embryonic stem cells
T13137 23016-23025 UBERON:0000922 denotes embryonic
T13136 22994-22998 SO:0000704 denotes gene
T13135 22876-22881 SO:0000704 denotes genes
T13134 22731-22738 GO:0005634 denotes nuclear
T13133 22601-22608 CHEBI:60425 denotes amyloid
T13132 22595-22620 PR:000004126 denotes serum amyloid P component
T13131 22595-22600 UBERON:0001977 denotes serum
T13130 22568-22572 SO:0000704 denotes gene
T13129 22563-22567 PR:000004126 denotes Apcs
T13128 22546-22550 NCBITaxon:10088 denotes mice
T13127 22455-22462 GO:0005634 denotes nuclear
T13126 22311-22316 NCBITaxon:10088 denotes mouse
T13125 22257-22261 SO:0000704 denotes gene
T13124 22226-22233 NCBITaxon:33208 denotes animals
T13123 22200-22206 UBERON:0002405 denotes immune
T13122 22147-22151 NCBITaxon:10088 denotes mice
T13121 22066-22070 SO:0000704 denotes gene
T13120 22035-22040 NCBITaxon:10088 denotes mouse
T13119 21916-21920 NCBITaxon:10088 denotes mice
T13118 21902-21906 SO:0000704 denotes gene
T13117 21848-21853 SO:0000704 denotes genes
T13293 33029-33036 SO:0000704 denotes genetic
T13292 33000-33006 UBERON:0002405 denotes immune
T13291 32926-32930 SO:0000704 denotes gene
T13290 32856-32863 SO:0001026 denotes genomes
T13289 32744-32749 UBERON:0002113 denotes renal
T13288 32716-32720 PR:000004126 denotes Apcs
T13287 32612-32617 SO:0000704 denotes genes
T13286 32551-32555 NCBITaxon:10088 denotes mice
T13285 32480-32485 UBERON:0000062 denotes organ
T13284 32439-32444 SO:0000704 denotes genes
T13283 32218-32222 NCBITaxon:10088 denotes mice
T13282 32210-32214 PR:000004126 denotes Apcs
T13281 32197-32201 NCBITaxon:10088 denotes mice
T13280 32142-32148 NCBITaxon:9606 denotes humans
T13279 32082-32100 PR:000005897 denotes C-reactive protein
T13278 31971-31983 UBERON:0001225 denotes renal cortex
T13277 31954-31963 GO:0032991 denotes complexes
T13276 31947-31953 UBERON:0002405 denotes immune
T13275 31823-31827 PR:000004126 denotes Apcs
T13274 31784-31795 GO:0006953 denotes acute-phase
T13273 31761-31779 PR:000005897 denotes C-reactive protein
T13272 31755-31760 NCBITaxon:9606 denotes human
T13271 31737-31747 GO:0010467 denotes expression
T13270 31642-31646 PR:000004126 denotes Apcs
T13269 31576-31584 GO:0019882 denotes antigens
T13268 31558-31571 _FRAGMENT denotes processing of
T13267 31528-31532 PR:000004126 denotes Apcs
T13266 31481-31485 NCBITaxon:10088 denotes mice
T13265 31449-31453 NCBITaxon:10088 denotes mice
T13264 31441-31445 PR:000004126 denotes Apcs
T13263 31358-31362 NCBITaxon:10088 denotes mice
T13262 31305-31309 NCBITaxon:10088 denotes mice
T13261 31297-31301 PR:000004126 denotes Apcs
T13260 31230-31237 GO:0005634 denotes nuclear
T13259 31155-31161 SO:0001023 denotes allele
T13258 31108-31113 SO:0000704 denotes genes
T13257 31078-31085 NCBITaxon:33208 denotes animals
T13256 31064-31068 SO:0000704 denotes gene
T13255 31003-31007 SO:0000704 denotes gene
T13254 30948-30954 NCBITaxon:39107 denotes murine
T13253 30857-30864 SO:0000704 denotes genetic
T13252 30789-30809 CL:0002322 denotes embryonic stem cells
T13251 30789-30798 UBERON:0000922 denotes embryonic
T13250 30736-30740 NCBITaxon:10088 denotes mice
T13249 30702-30708 UBERON:0002405 denotes immune
T13248 30654-30658 PR:000025662 denotes CD55
T13247 30627-30652 PR:000025662 denotes decay-accelerating factor
T13246 30577-30580 PR:000001337 denotes CR1
T13245 30519-30526 PR:000001479 denotes FcγRIIB
T13244 30506-30510 NCBITaxon:10088 denotes mice
T13243 30415-30420 SO:0000704 denotes genes
T13242 30383-30387 NCBITaxon:10088 denotes mice
T13241 30323-30326 GO:0042571 denotes Abs
T13240 30233-30237 SO:0000704 denotes gene
T13239 30155-30161 SO:0001026 denotes genome
T13238 30010-30014 SO:0000704 denotes gene
T13237 30005-30009 PR:000004126 denotes Apcs
T13236 29870-29875 SO:0000704 denotes genic
T13235 29852-29859 SO:0001023 denotes alleles
T13234 29684-29688 NCBITaxon:10088 denotes mice
T13233 29584-29591 SO:0001026 denotes genomic
T13232 29511-29516 SO:0000704 denotes genes
T8691 20779-20784 UBERON:0002113 denotes renal
T8690 20733-20740 SO:0001023 denotes alleles
T8689 20679-20683 PR:000004126 denotes Apcs
T8688 20598-20602 PR:000004126 denotes Apcs
T8687 20518-20525 UBERON:0002113 denotes kidneys
T8686 20415-20422 GO:0005634 denotes nuclear
T8685 20357-20362 SO:0000704 denotes genes
T8684 20243-20247 SO:0000704 denotes gene
T8683 20238-20242 PR:000004126 denotes Apcs
T8682 20199-20203 NCBITaxon:10088 denotes mice
T8681 20114-20117 GO:0042571 denotes Abs
T8680 20084-20093 GO:0010467 denotes expressed
T8679 20071-20078 NCBITaxon:33208 denotes animals
T8678 19979-19983 PR:000004126 denotes Apcs
T8677 19936-19939 GO:0042571 denotes Abs
T8676 19789-19794 UBERON:0002113 denotes renal
T8675 19767-19770 GO:0042571 denotes Abs
T8674 19733-19740 NCBITaxon:33208 denotes animals
T8673 19694-19698 NCBITaxon:10088 denotes mice
T8672 19685-19689 PR:000004126 denotes Apcs
T8671 19472-19476 PR:000004126 denotes Apcs
T8670 19454-19460 SO:0001026 denotes genome
T8669 19440-19444 NCBITaxon:10088 denotes mice
T8668 19431-19435 PR:000004126 denotes Apcs
T8667 19342-19346 PR:000004126 denotes Apcs
T8666 19283-19287 NCBITaxon:10088 denotes mice
T8665 19274-19278 PR:000004126 denotes Apcs
T8664 19214-19218 NCBITaxon:10088 denotes mice
T8663 19179-19183 NCBITaxon:10088 denotes mice
T8662 18992-18996 NCBITaxon:10088 denotes mice
T8661 18889-18896 SO:0001026 denotes genomic
T8660 18553-18560 SO:0000704 denotes genetic
T8659 18467-18472 SO:0000704 denotes genic
T8658 18417-18422 NCBITaxon:10088 denotes mouse
T6626 18200-18203 SO:0000771 denotes QTL
T6625 18148-18152 NCBITaxon:10088 denotes mice
T6624 18040-18044 NCBITaxon:10088 denotes mice
T6623 18031-18035 PR:000004126 denotes Apcs
T6622 17736-17740 NCBITaxon:10088 denotes mice
T6621 17640-17643 SO:0000771 denotes QTL
T6620 16727-16731 NCBITaxon:10088 denotes mice
T6619 16638-16643 SO:0000704 denotes genes
T6618 16555-16562 SO:0001023 denotes alleles
T6617 16402-16409 SO:0000704 denotes genetic
T6616 16355-16361 UBERON:0002405 denotes immune
T6615 16283-16292 GO:0000785 denotes chromatin
T6614 16093-16100 SO:0001026 denotes genomic
T6613 16024-16030 UBERON:0002405 denotes immune
T6612 15165-15171 NCBITaxon:39107 denotes murine
T6611 15158-15164 UBERON:0002405 denotes immune
T6610 15140-15146 UBERON:0002405 denotes immune
T6609 15087-15091 PR:000004126 denotes Apcs
T6608 14880-14884 SO:0000704 denotes gene
T6607 14875-14879 PR:000004126 denotes Apcs
T6606 14780-14784 PR:000004126 denotes Apcs
T6605 14680-14684 PR:000004126 denotes Apcs
T6604 14650-14656 NCBITaxon:39107 denotes murine
T6603 14470-14474 NCBITaxon:10088 denotes mice
T6602 14424-14428 PR:000004126 denotes Apcs
T6601 14383-14387 NCBITaxon:10088 denotes mice
T6600 14323-14325 GO:0042571 denotes Ab
T6599 14313-14322 GO:0000785 denotes chromatin
T6598 14263-14267 PR:000004126 denotes Apcs
T6597 13887-13891 NCBITaxon:10088 denotes mice
T6596 13854-13858 NCBITaxon:10088 denotes mice
T6595 13845-13849 PR:000004126 denotes Apcs
T6594 13811-13814 GO:0042571 denotes Abs
T6593 13761-13765 SO:0000704 denotes gene
T6592 13756-13760 PR:000004126 denotes Apcs
T6591 13716-13720 SO:0000704 denotes gene
T6590 13711-13715 PR:000004126 denotes Apcs
T6589 13651-13658 SO:0000704 denotes gene(s)
T6588 13629-13633 NCBITaxon:10088 denotes mice
T6587 13620-13624 PR:000004126 denotes Apcs
T6586 13601-13603 GO:0042571 denotes Ab
T6585 13591-13600 GO:0000785 denotes chromatin
T6584 12500-12505 NCBITaxon:10088 denotes mouse
T6583 12466-12473 SO:0000704 denotes genetic
T6582 12375-12377 GO:0042571 denotes Ab
T6581 12344-12348 SO:0000704 denotes gene
T6580 12339-12343 PR:000004126 denotes Apcs
T6579 12165-12167 GO:0042571 denotes Ab
T6578 12155-12164 GO:0000785 denotes chromatin
T6577 12075-12080 NCBITaxon:10088 denotes mouse
T6576 11923-11926 SO:0000771 denotes QTL
T494 44-48 NCBITaxon:10088 denotes Mice
T495 92-96 SO:0000704 denotes Gene
T496 106-110 NCBITaxon:10088 denotes Mice
T497 202-208 UBERON:0000467 denotes system
T498 213-219 UBERON:0002405 denotes immune
T499 246-253 SO:0000704 denotes genetic
T500 305-309 SO:0000704 denotes gene
T501 319-323 NCBITaxon:10088 denotes mice
T502 380-385 SO:0000704 denotes genes
T503 463-467 NCBITaxon:10088 denotes mice
T504 502-506 SO:0000704 denotes gene
T505 516-520 NCBITaxon:10088 denotes mice
T506 573-580 SO:0000704 denotes genetic
T507 620-626 UBERON:0002405 denotes immune
T508 647-651 SO:0000704 denotes gene
T509 661-665 NCBITaxon:10088 denotes mice
T510 706-716 GO:0010467 denotes expression
T511 770-775 SO:0000704 denotes genes
T512 808-813 NCBITaxon:10088 denotes mouse
T513 829-835 SO:0001026 denotes genome
T514 931-935 NCBITaxon:10088 denotes mice
T515 1159-1166 GO:0005634 denotes nuclear
T516 1167-1175 CHEBI:59132 denotes antigens
T517 1229-1233 SO:0000704 denotes gene
T518 1326-1331 NCBITaxon:10088 denotes mouse
T519 1356-1360 SO:0000704 denotes gene
T520 1389-1393 SO:0000704 denotes gene
T521 1451-1457 UBERON:0002405 denotes immune
T522 1483-1487 SO:0000704 denotes gene
T2600 1967-1974 SO:0000704 denotes Genetic
T2595 1782-1788 UBERON:0002405 denotes immune
T2596 1836-1846 GO:0042571 denotes antibodies
T2597 1853-1856 GO:0042571 denotes Abs
T2598 1890-1898 CHEBI:59132 denotes antigens
T2599 1953-1965 GO:0005634 denotes cell nucleus
T2601 2051-2057 NCBITaxon:9606 denotes humans
T2602 2062-2069 NCBITaxon:33208 denotes animals
T2603 2164-2169 SO:0000704 denotes Genes
T2604 2279-2284 SO:0000704 denotes genes
T2605 2344-2351 SO:0000704 denotes genetic
T2606 2416-2422 NCBITaxon:39107 denotes murine
T2607 2491-2496 SO:0000704 denotes genes
T2608 2497-2507 GO:0065007 denotes modulating
T2609 2512-2525 UBERON:0002405 denotes immune system
T2610 2614-2618 NCBITaxon:10088 denotes mice
T2611 2803-2815 PR:000001962 denotes FAS receptor
T2612 2816-2820 SO:0000704 denotes gene
T2613 2861-2873 GO:0000806 denotes Y chromosome
T2614 2878-2884 UBERON:0002405 denotes immune
T2615 2903-2907 SO:0000704 denotes gene
T2616 2951-2958 SO:0000704 denotes genetic
T2617 3161-3168 SO:0000704 denotes genetic
T2618 3257-3262 SO:0000704 denotes genes
T2619 3631-3636 SO:0000704 denotes genes
T2620 3799-3804 SO:0000704 denotes genes
T2621 3905-3912 SO:0000704 denotes genetic
T2622 3967-3973 NCBITaxon:39107 denotes murine
T2623 4065-4072 SO:0000704 denotes genetic
T2624 4097-4102 SO:0000704 denotes genes
T2625 4128-4141 UBERON:0002405 denotes immune system
T2626 4193-4199 UBERON:0002405 denotes immune
T2627 4200-4210 GO:0065007 denotes regulation
T2628 4361-4367 UBERON:0002405 denotes immune
T2629 4453-4457 NCBITaxon:10088 denotes mice
T2630 4492-4496 SO:0000704 denotes gene
T2631 4506-4510 NCBITaxon:10088 denotes mice
T2632 4729-4736 SO:0000704 denotes genetic
T2633 4776-4782 UBERON:0002405 denotes immune
T2634 4796-4800 SO:0000704 denotes gene
T2635 4810-4814 NCBITaxon:10088 denotes mice
T2636 4947-4953 UBERON:0002405 denotes immune
T2637 4982-4986 SO:0000704 denotes gene
T2638 4996-5000 NCBITaxon:10088 denotes mice
T2639 5077-5082 SO:0000704 denotes genes
T2640 5117-5121 NCBITaxon:10088 denotes mice
T2641 5167-5173 SO:0001023 denotes allele
T2642 5204-5210 SO:0001026 denotes genome
T2643 5272-5276 NCBITaxon:10088 denotes mice
T2644 5317-5322 UBERON:0001977 denotes serum
T2645 5317-5342 PR:000004126 denotes serum amyloid P component
T2646 5323-5330 CHEBI:60425 denotes amyloid
T2647 5343-5347 SO:0000704 denotes gene
T2648 5349-5353 PR:000004126 denotes Apcs
T2649 5360-5364 PR:000004126 denotes Apcs
T2650 5375-5379 NCBITaxon:10088 denotes mice
T2651 5381-5385 PR:000004126 denotes Apcs
T2652 5422-5426 SO:0000704 denotes gene
T2653 5509-5516 SO:0000704 denotes genetic
T2654 5561-5565 PR:000004126 denotes Apcs
T2655 5570-5574 NCBITaxon:10088 denotes mice
T2656 5620-5624 SO:0000704 denotes gene
T2657 5688-5692 SO:0000704 denotes gene
T2658 5726-5730 PR:000004126 denotes Apcs
T2659 5731-5735 SO:0000704 denotes gene
T2660 6099-6104 SO:0000704 denotes genes
T2661 6131-6137 PR:000001479 denotes FcγRII
T2662 6163-6166 PR:000001337 denotes CR1
T2663 6170-6174 PR:000001337 denotes CD35
T2664 6175-6179 PR:000001338 denotes CD21
T2665 6216-6220 PR:000025662 denotes CD55
T2666 6380-6384 SO:0000704 denotes gene
T2667 6402-6411 UBERON:0000922 denotes embryonic
T2668 6402-6422 CL:0002322 denotes embryonic stem cells
T2669 6461-6468 SO:0000704 denotes genetic
T2670 6509-6513 NCBITaxon:10088 denotes mice
T2671 6639-6645 SO:0001026 denotes genome
T2672 6709-6713 SO:0000704 denotes gene
T2673 6747-6756 UBERON:0000922 denotes embryonic
T2674 6747-6767 CL:0002322 denotes embryonic stem cells
T2675 6876-6880 PR:000004126 denotes Apcs
T2676 6881-6885 SO:0000704 denotes gene
T2677 6954-6959 SO:0000704 denotes genes
T2678 6981-6988 SO:0001026 denotes genomes
T2679 7075-7080 SO:0000704 denotes genes
T2680 7123-7129 UBERON:0002405 denotes immune
T2681 7166-7173 SO:0000704 denotes genetic
T4398 7255-7259 PR:000004126 denotes Apcs
T4399 7264-7268 NCBITaxon:10088 denotes Mice
T4400 7288-7295 SO:0000704 denotes genetic
T4401 7367-7371 NCBITaxon:10088 denotes mice
T4402 7425-7432 NCBITaxon:33208 denotes animals
T4403 7465-7469 PR:000004126 denotes Apcs
T4404 7470-7474 SO:0000704 denotes gene
T4405 7558-7562 NCBITaxon:10088 denotes mice
T4406 7673-7677 NCBITaxon:10088 denotes mice
T4407 7842-7846 NCBITaxon:10088 denotes mice
T4408 7899-7902 GO:0042571 denotes Abs
T4409 8101-8108 GO:0005634 denotes nuclear
T4410 8109-8112 GO:0042571 denotes Abs
T4411 8129-8138 GO:0000785 denotes chromatin
T4412 8139-8141 GO:0042571 denotes Ab
T4413 8193-8197 PR:000004126 denotes Apcs
T4414 8202-8206 NCBITaxon:10088 denotes mice
T4415 8368-8383 SO:0000984 denotes single-stranded
T4416 8405-8420 SO:0000985 denotes double-stranded
T4417 8433-8436 GO:0042571 denotes Abs
T4418 8462-8467 UBERON:0002113 denotes renal
T4419 8617-8625 SO:0000357 denotes flanking
T4420 8638-8642 PR:000004126 denotes Apcs
T4421 8643-8647 SO:0000704 denotes gene
T4422 8660-8666 UBERON:0002405 denotes immune
T4423 8688-8694 SO:0001026 denotes genome
T6575 11895-11921 SO:0000771 denotes quantitative trait linkage
T6568 9520-9524 NCBITaxon:10088 denotes Mice
T6569 9599-9608 GO:0030849 denotes autosomes
T6570 9630-9635 SO:0000704 denotes genes
T6571 9697-9703 SO:0001026 denotes genome
T6572 9791-9807 SO:0000018 denotes areas of linkage
T6573 10077-10081 PR:000004126 denotes Apcs
T6574 10086-10090 NCBITaxon:10088 denotes mice
T13200 27845-27849 SO:0000704 denotes gene
T13199 27840-27844 PR:000004126 denotes Apcs
T13198 27805-27810 NCBITaxon:9606 denotes human
T13197 27745-27750 NCBITaxon:9606 denotes human
T13196 27718-27729 SO:0000858 denotes orthologous
T13195 27696-27701 NCBITaxon:10088 denotes mouse
T13194 27424-27430 SO:0001026 denotes genome
T13193 27418-27423 NCBITaxon:10088 denotes mouse
T13192 27399-27402 GO:0042611 denotes MHC
T16591 33856-33860 NCBITaxon:10088 denotes mice
T16590 33769-33773 NCBITaxon:10088 denotes mice
T16589 33753-33757 PR:000004126 denotes Apcs
T16588 33640-33647 NCBITaxon:33208 denotes animals
T16587 33631-33635 PR:000004126 denotes Apcs
T16586 33607-33614 SO:0000704 denotes genetic
T16585 33591-33595 NCBITaxon:10088 denotes mice
T16584 33582-33586 PR:000004126 denotes Apcs
T16583 33545-33549 NCBITaxon:10088 denotes mice
T16582 33536-33540 PR:000004126 denotes Apcs
T16581 33446-33450 NCBITaxon:10088 denotes mice
T16580 33438-33442 PR:000004126 denotes Apcs
T16579 33428-33432 NCBITaxon:10088 denotes mice
T16578 33384-33388 NCBITaxon:10088 denotes mice
T16577 33299-33303 NCBITaxon:10088 denotes mice
T16576 33215-33221 NCBITaxon:33208 denotes animal
T16575 33088-33092 NCBITaxon:10088 denotes mice
T16574 33074-33078 NCBITaxon:10088 denotes Mice
T18219 37047-37056 UBERON:0000074 denotes glomeruli
T18218 37001-37010 UBERON:0000074 denotes glomeruli
T18217 36950-36960 UBERON:0000074 denotes glomerular
T18216 36930-36939 UBERON:0000074 denotes glomeruli
T18215 36900-36915 UBERON:0005749 denotes glomerular tuft
T18214 36829-36838 UBERON:0000074 denotes glomeruli
T18213 36799-36814 UBERON:0005749 denotes glomerular tuft
T18212 36648-36655 CHEBI:33893 denotes reagent
T18211 36627-36640 CHEBI:29149 denotes periodic acid
T18210 36564-36572 CHEBI:75958 denotes solution
T18209 36526-36532 UBERON:0002113 denotes kidney
T18208 36452-36456 GO:0016265 denotes died
T18207 36426-36430 NCBITaxon:10088 denotes mice
T19153 38358-38361 SO:0000771 denotes QTL
T19152 38289-38292 GO:0042571 denotes Abs
T19151 38225-38229 NCBITaxon:10088 denotes mice
T19150 38093-38096 SO:0000771 denotes QTL
T19149 38070-38073 SO:0000771 denotes QTL
R3033 T13269 T13268 _lexicallyChainedTo antigens,processing of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T19259 38622-38625 CD denotes 7.8
T19258 38620-38621 SYM denotes ≤
T19299 38726-38727 . denotes .
T19298 38725-38726 -RRB- denotes )
T19297 38721-38725 CD denotes 1999
T19296 38715-38720 NNP denotes Olson
T19295 38711-38714 CC denotes and
T19294 38705-38710 NNP denotes Manly
T19293 38704-38705 -LRB- denotes (
T19292 38691-38703 RB denotes respectively
T19291 38689-38691 , denotes ,
T19290 38688-38689 -RRB- denotes )
T19289 38686-38687 SYM denotes −
T19288 38684-38686 CD denotes 10
T19287 38682-38683 SYM denotes ×
T19286 38680-38681 CD denotes 1
T19285 38678-38679 SYM denotes ≤
T19284 38676-38677 NN denotes p
T19283 38687-38688 CD denotes 5
T19282 38675-38676 -LRB- denotes (
T19281 38673-38674 CD denotes 5
T19280 38671-38672 SYM denotes ≥
T19279 38667-38670 NN denotes LOD
T19278 38663-38666 CC denotes and
T19277 38661-38663 , denotes ,
T19276 38660-38661 -RRB- denotes )
T19275 38658-38659 SYM denotes −
T19274 38656-38658 CD denotes 10
T19273 38654-38655 SYM denotes ×
T19272 38650-38653 CD denotes 2.4
T19271 38648-38649 SYM denotes ≤
T19270 38646-38647 NN denotes p
T19269 38659-38660 CD denotes 4
T19268 38645-38646 -LRB- denotes (
T19267 38641-38644 CD denotes 3.6
T19266 38639-38640 SYM denotes ≥
T19265 38635-38638 NN denotes LOD
T19264 38633-38635 , denotes ,
T19263 38632-38633 -RRB- denotes )
T19262 38630-38631 SYM denotes −
T19261 38628-38630 CD denotes 10
T19260 38626-38627 SYM denotes ×
T19257 38618-38619 NN denotes p
T19256 38631-38632 CD denotes 3
T19255 38617-38618 -LRB- denotes (
T19254 38613-38616 CD denotes 2.1
T19253 38611-38612 SYM denotes ≥
T19252 38607-38610 NN denotes LOD
T19251 38581-38592 JJ denotes significant
T19250 38574-38580 RB denotes highly
T19249 38570-38573 CC denotes and
T19248 38568-38570 , denotes ,
T19247 38557-38568 JJ denotes significant
T19246 38555-38557 , denotes ,
T19245 38593-38601 NNS denotes linkages
T19244 38545-38555 JJ denotes suggestive
T19243 38541-38544 IN denotes for
T19242 38602-38606 VBD denotes were
T19241 38523-38530 JJ denotes average
T19240 38531-38540 NN denotes threshold
T19239 38519-38522 DT denotes The
T19238 38518-38727 sentence denotes The average threshold for suggestive, significant, and highly significant linkages were LOD ≥ 2.1 (p ≤ 7.8 × 10−3), LOD ≥ 3.6 (p ≤ 2.4 × 10−4), and LOD ≥ 5 (p ≤ 1 × 10−5), respectively (Manly and Olson 1999).
T19237 38517-38518 . denotes .
T19236 38516-38517 -RRB- denotes )
T19235 38498-38503 CD denotes 1,000
T19234 38504-38516 NNS denotes permutations
T19233 38497-38498 -LRB- denotes (
T19232 38480-38491 NN denotes permutation
T19231 38470-38471 HYPH denotes -
T19230 38465-38470 NN denotes trait
T19229 38461-38464 CC denotes and
T19228 38459-38460 HYPH denotes -
T19227 38471-38479 JJ denotes specific
T19226 38453-38459 NN denotes cohort
T19225 38492-38496 NN denotes test
T19224 38451-38452 DT denotes a
T19223 38445-38450 VBG denotes using
T19222 38442-38444 IN denotes by
T19221 38426-38430 VBD denotes were
T19220 38405-38416 JJ denotes significant
T19219 38401-38404 CC denotes and
T19218 38417-38425 NNS denotes linkages
T19217 38390-38400 JJ denotes suggestive
T19216 38386-38389 IN denotes for
T19215 38431-38441 VBN denotes determined
T19214 38375-38385 NNS denotes thresholds
T19213 38371-38374 NN denotes LOD
T19212 38370-38518 sentence denotes LOD thresholds for suggestive and significant linkages were determined by using a cohort- and trait-specific permutation test (1,000 permutations).
T19211 38369-38370 . denotes .
T19210 38362-38369 NN denotes mapping
T19209 38358-38361 NN denotes QTL
T19208 38355-38357 IN denotes in
T19207 38350-38354 VBN denotes used
T19206 38345-38349 VBD denotes were
T19205 38341-38344 CC denotes and
T19204 38328-38340 NN denotes distribution
T19203 38317-38327 VBN denotes normalised
T19202 38312-38316 RBR denotes more
T19201 38309-38311 IN denotes in
T19200 38293-38299 NNS denotes levels
T19199 38284-38292 NNS denotes auto-Abs
T19198 38281-38283 IN denotes of
T19197 38300-38308 VBD denotes resulted
T19196 38265-38280 NNS denotes transformations
T19195 38261-38264 NN denotes Log
T19194 38260-38370 sentence denotes Log transformations of auto-Abs levels resulted in more normalised distribution and were used in QTL mapping.
T19193 38259-38260 . denotes .
T19192 38246-38250 VBD denotes were
T19191 38242-38245 NN denotes age
T19190 38239-38241 IN denotes of
T19189 38236-38238 NN denotes mo
T19188 38233-38235 CD denotes 12
T19187 38230-38232 IN denotes at
T19186 38225-38229 NNS denotes mice
T19185 38220-38224 IN denotes from
T19184 38251-38259 VBN denotes analysed
T19183 38215-38219 NNS denotes data
T19182 38210-38214 RB denotes Only
T19181 38209-38260 sentence denotes Only data from mice at 12 mo of age were analysed.
T19180 38208-38209 . denotes .
T19179 38195-38208 RB denotes independently
T19178 38181-38185 VBD denotes were
T19177 38186-38194 VBN denotes examined
T19176 38161-38173 JJ denotes experimental
T18632 37577-37578 . denotes .
T18631 37569-37572 VBD denotes was
T18630 37553-37563 NN denotes comparison
T18629 37544-37552 JJ denotes multiple
T18628 37541-37543 POS denotes 's
T18627 37564-37568 NN denotes test
T18626 37537-37541 NNP denotes Dunn
T18603 37420-37427 NNP denotes Whitney
T18602 37415-37419 NNP denotes Mann
T18601 37428-37432 NN denotes test
T18600 37411-37414 DT denotes The
T18599 37410-37578 sentence denotes The Mann–Whitney test was used for comparison of two groups, whilst for analysis of three groups the Kruskal–Wallis test with Dunn's multiple comparison test was used.
T18598 37409-37410 . denotes .
T18597 37405-37409 CD denotes 0.05
T18596 37403-37404 SYM denotes <
T18595 37396-37402 NNS denotes values
T18594 37394-37395 NN denotes p
T18593 37390-37393 IN denotes for
T18592 37378-37389 JJ denotes significant
T18591 37361-37366 VBG denotes being
T18590 37367-37377 VBN denotes considered
T18589 37349-37360 NNS denotes differences
T18588 37344-37348 IN denotes with
T18587 37342-37344 , denotes ,
T18586 37332-37342 RB denotes throughout
T18585 37319-37323 VBD denotes were
T18584 37324-37331 VBN denotes applied
T18583 37313-37318 NNS denotes tests
T18582 37298-37312 JJ denotes Non-parametric
T18581 37297-37410 sentence denotes Non-parametric tests were applied throughout, with differences being considered significant for p values < 0.05.
T18580 37296-37297 . denotes .
T18579 37295-37296 -RRB- denotes )
T18578 37289-37295 NNP denotes States
T18577 37282-37288 NNP denotes United
T18576 37280-37282 , denotes ,
T18575 37270-37280 NNP denotes California
T18574 37268-37270 , denotes ,
T18573 37263-37268 NNP denotes Diego
T18572 37259-37262 NNP denotes San
T18571 37257-37259 , denotes ,
T18570 37240-37248 NNP denotes GraphPad
T18569 37249-37257 NNP denotes Software
T18568 37239-37240 -LRB- denotes (
T18567 37231-37238 NNP denotes Windows
T18566 37227-37230 IN denotes for
T18565 37223-37226 CD denotes 3.0
T18564 37215-37222 NN denotes version
T18563 37207-37214 NNP denotes PrismTM
T18562 37198-37206 NNP denotes GraphPad
T18561 37192-37197 VBG denotes using
T18560 37176-37180 VBD denotes were
T18559 37181-37191 VBN denotes calculated
T18558 37165-37175 NNS denotes statistics
T18557 37161-37164 DT denotes All
T18556 37160-37297 sentence denotes All statistics were calculated using GraphPad PrismTM version 3.0 for Windows (GraphPad Software, San Diego, California, United States).
T18555 37159-37160 . denotes .
T18554 37148-37159 NNS denotes parentheses
T18553 37145-37147 IN denotes in
T18552 37138-37144 NNS denotes values
T18551 37135-37137 IN denotes of
T18860 37815-37818 CC denotes and
T18859 37809-37814 NN denotes MgCl2
T18858 37806-37808 NN denotes mM
T18857 37802-37805 CD denotes 1.5
T18856 37791-37801 VBG denotes containing
T18855 37782-37790 NNS denotes reagents
T18854 37773-37781 JJ denotes standard
T18853 37767-37772 VBG denotes using
T18852 37752-37756 VBD denotes were
T18851 37757-37766 VBN denotes performed
T18850 37747-37751 NNS denotes PCRs
T18849 37746-37834 sentence denotes PCRs were performed using standard reagents containing 1.5 mM MgCl2 and 0.4 μM primers.
T18848 37745-37746 . denotes .
T18847 37733-37735 CD denotes 19
T18846 37736-37745 NNS denotes autosomes
T18845 37729-37732 DT denotes all
T18844 37718-37728 IN denotes throughout
T18843 37706-37717 VBN denotes distributed
T18842 37704-37705 -RRB- denotes )
T18337 36911-36915 NN denotes tuft
T18336 36896-36899 DT denotes the
T18335 36893-36895 IN denotes of
T18334 36891-36892 NN denotes %
T18333 36884-36888 IN denotes than
T18332 36889-36891 CD denotes 50
T18331 36876-36883 JJR denotes greater
T18330 36866-36875 VBG denotes involving
T18329 36847-36849 , denotes ,
T18328 36846-36847 CD denotes 2
T18327 36849-36865 NN denotes hypercellularity
T18326 36840-36845 NN denotes grade
T18325 36838-36839 : denotes ;
T18324 36829-36838 NNS denotes glomeruli
T18323 36826-36828 IN denotes of
T18322 36822-36824 CD denotes 50
T18321 36824-36825 NN denotes %
T18320 36821-36822 SYM denotes –
T18319 36820-36821 NN denotes %
T18318 36818-36820 CD denotes 25
T18317 36815-36817 IN denotes in
T18316 36799-36809 JJ denotes glomerular
T18315 36810-36814 NN denotes tuft
T18314 36795-36798 DT denotes the
T18313 36792-36794 IN denotes of
T18312 36790-36791 NN denotes %
T18311 36783-36787 IN denotes than
T18310 36788-36790 CD denotes 50
T18309 36775-36782 JJR denotes greater
T18308 36765-36774 VBG denotes involving
T18307 36746-36748 , denotes ,
T18306 36745-36746 CD denotes 1
T18305 36748-36764 NN denotes hypercellularity
T18304 36739-36744 NN denotes grade
T18303 36737-36738 : denotes ;
T18302 36731-36737 JJ denotes normal
T18301 36729-36731 , denotes ,
T18300 36728-36729 CD denotes 0
T18299 36961-36977 NN denotes hypercellularity
T18298 36722-36727 NN denotes grade
T18297 36720-36722 : denotes :
T18296 36713-36720 VBZ denotes follows
T18295 36710-36712 IN denotes as
T18294 36694-36701 JJ denotes blinded
T18293 36702-36709 NN denotes fashion
T18292 36692-36693 DT denotes a
T18291 36689-36691 IN denotes in
T18290 36678-36681 VBD denotes was
T18289 36682-36688 VBN denotes graded
T18288 36668-36677 NN denotes histology
T18287 36657-36667 JJ denotes Glomerular
T18286 36656-37057 sentence denotes Glomerular histology was graded in a blinded fashion as follows: grade 0, normal; grade 1, hypercellularity involving greater than 50% of the glomerular tuft in 25%–50% of glomeruli; grade 2, hypercellularity involving greater than 50% of the glomerular tuft in 50%–75% of glomeruli; grade 3, glomerular hypercellularity in greater than 75% of glomeruli or crescents in greater than 25% of glomeruli.
T18285 36655-36656 . denotes .
T18284 36648-36655 NN denotes reagent
T18283 36641-36647 NNP denotes Schiff
T18282 36640-36641 HYPH denotes –
T18281 36636-36640 NN denotes acid
T18280 36627-36635 JJ denotes periodic
T18279 36622-36626 IN denotes with
T18278 36609-36613 VBD denotes were
T18277 36614-36621 VBN denotes stained
T18276 36600-36608 NNS denotes sections
T18275 36596-36599 CC denotes and
T18274 36594-36596 , denotes ,
T18273 36586-36594 VBN denotes embedded
T18272 36577-36585 NN denotes paraffin
T18271 36573-36576 CC denotes and
T18625 37532-37536 IN denotes with
T18624 37519-37520 HYPH denotes –
T18623 37520-37526 NNP denotes Wallis
T18622 37512-37519 NNP denotes Kruskal
T18621 37527-37531 NN denotes test
T18620 37508-37511 DT denotes the
T18619 37501-37507 NNS denotes groups
T18618 37495-37500 CD denotes three
T18617 37492-37494 IN denotes of
T18616 37483-37491 NN denotes analysis
T18615 37479-37482 IN denotes for
T18614 37573-37577 VBN denotes used
T18613 37472-37478 IN denotes whilst
T18612 37470-37472 , denotes ,
T18611 37464-37470 NNS denotes groups
T18610 37460-37463 CD denotes two
T18609 37457-37459 IN denotes of
T18608 37446-37456 NN denotes comparison
T18607 37442-37445 IN denotes for
T18606 37433-37436 VBD denotes was
T18605 37437-37441 VBN denotes used
T18604 37419-37420 HYPH denotes –
T18270 36561-36563 POS denotes 's
T18269 36564-36572 NN denotes solution
T18268 36556-36561 NNP denotes Bouin
T18267 36553-36555 IN denotes in
T18266 36542-36546 VBD denotes were
T18265 36547-36552 VBN denotes fixed
T18264 36533-36541 NNS denotes portions
T18263 36526-36532 NN denotes kidney
T18262 36522-36525 CC denotes and
T18261 36520-36522 , denotes ,
T18260 36517-36520 NN denotes age
T18259 36514-36516 IN denotes of
T18258 36512-36513 NN denotes y
T18257 36510-36511 CD denotes 1
T18256 36507-36509 IN denotes at
T18255 36491-36495 VBD denotes were
T18254 36489-36491 , denotes ,
T18253 36479-36489 NN denotes experiment
T18252 36475-36478 DT denotes the
T18251 36472-36474 IN denotes of
T18250 36468-36471 NN denotes end
T18249 36464-36467 DT denotes the
T18248 36457-36463 IN denotes before
T18247 36452-36456 VBD denotes died
T18246 36447-36451 WDT denotes that
T18245 36443-36446 JJ denotes few
T18244 36439-36442 DT denotes the
T18243 36432-36438 IN denotes except
T18242 36430-36432 , denotes ,
T18241 36496-36506 VBN denotes sacrificed
T18240 36422-36425 DT denotes the
T18239 36426-36430 NNS denotes mice
T18238 36418-36421 PDT denotes All
T18237 36417-36656 sentence denotes All the mice, except the few that died before the end of the experiment, were sacrificed at 1 y of age, and kidney portions were fixed in Bouin's solution and paraffin embedded, and sections were stained with periodic acid–Schiff reagent.
T18236 36416-36417 . denotes .
T18235 36408-36416 NN denotes analysis
T18234 36395-36407 JJ denotes Histological
T17919 36212-36215 IN denotes per
T17918 36201-36211 NNS denotes milligrams
T17917 36198-36200 IN denotes in
T17916 36183-36187 VBD denotes were
T17915 36188-36197 VBN denotes expressed
T17914 36175-36182 NNS denotes results
T17913 36171-36174 DT denotes the
T17912 36167-36170 CC denotes and
T17911 36165-36167 , denotes ,
T17910 36151-36156 CD denotes 3,000
T17909 36150-36151 SYM denotes :
T17908 36149-36150 CD denotes 1
T17907 36157-36165 NN denotes dilution
T17906 36147-36148 DT denotes a
T17905 36144-36146 IN denotes at
T17904 36130-36134 VBD denotes were
T17903 36135-36143 VBN denotes screened
T17902 36122-36129 NNS denotes Samples
T17901 36121-36336 sentence denotes Samples were screened at a 1:3,000 dilution, and the results were expressed in milligrams per liters, referring to a standard curve derived from an acute-phase serum with a known concentration of Apcs (Calbiochem).
T17900 36120-36121 . denotes .
T17899 36119-36120 -RRB- denotes )
T17898 36112-36119 NNP denotes Kingdom
T17897 36105-36111 NNP denotes United
T17896 36103-36105 , denotes ,
T17895 36094-36103 NNP denotes Nottigham
T17894 36092-36094 , denotes ,
T17893 36082-36092 NNP denotes Calbiochem
T17892 36081-36082 -LRB- denotes (
T17891 36061-36071 JJ denotes anti-mouse
T17890 36072-36076 NN denotes Apcs
T17889 36054-36060 NN denotes rabbit
T17888 36050-36053 CC denotes and
T17887 36077-36080 NNS denotes Abs
T17886 36034-36044 JJ denotes anti-mouse
T17885 36045-36049 NN denotes Apcs
T17884 36028-36033 NN denotes sheep
T17883 36022-36027 VBG denotes using
T17882 36016-36021 NNP denotes ELISA
T17881 36013-36015 IN denotes by
T17880 35999-36003 VBD denotes were
T17879 36004-36012 VBN denotes assessed
T17878 35992-35998 NNS denotes levels
T17877 35987-35991 NN denotes Apcs
T17876 35986-36121 sentence denotes Apcs levels were assessed by ELISA using sheep anti-mouse Apcs and rabbit anti-mouse Apcs Abs (Calbiochem, Nottigham, United Kingdom).
T17875 35985-35986 . denotes .
T17874 35980-35985 NN denotes plate
T17873 35975-35979 DT denotes each
T17872 35972-35974 IN denotes on
T17871 35958-35962 VBD denotes were
T17870 35945-35950 NN denotes serum
T17869 35937-35944 NN denotes control
T17868 35928-35936 JJ denotes positive
T17867 35951-35957 NN denotes sample
T17866 35926-35927 DT denotes a
T17865 35923-35925 IN denotes of
T17864 35913-35922 NNS denotes dilutions
T17863 35906-35912 JJ denotes serial
T17862 35904-35906 , denotes ,
T17861 35894-35904 NN denotes comparison
T17860 35883-35893 JJ denotes interplate
T17859 35963-35971 VBN denotes included
T17858 35879-35882 IN denotes For
T17857 35878-35986 sentence denotes For interplate comparison, serial dilutions of a positive control serum sample were included on each plate.
T17856 35877-35878 . denotes .
T17855 35874-35877 CD denotes 100
T17854 35871-35873 IN denotes of
T17853 35865-35870 NN denotes value
T17852 35863-35864 DT denotes a
T17851 35850-35853 VBD denotes was
T17850 35854-35862 VBN denotes assigned
T17849 35844-35849 WDT denotes which
T17848 35842-35844 , denotes ,
T17847 35841-35842 -RRB- denotes )
T17846 35831-35832 HYPH denotes /
T17845 35832-35835 NN denotes lpr
T17844 35828-35831 NN denotes lpr
T17843 35827-35828 HYPH denotes .
T17842 35824-35825 HYPH denotes /
T17841 35825-35827 NN denotes Mp
T17840 35821-35824 NN denotes MRL
T17796 35611-35613 IN denotes as
T17795 35609-35611 , denotes ,
T17794 35604-35609 NNP denotes ELISA
T17793 35601-35603 IN denotes by
T17792 35587-35591 VBD denotes were
T17791 35572-35586 NN denotes anti-chromatin
T17790 35568-35571 CC denotes and
T17789 35562-35567 NN denotes ssDNA
T17788 35559-35561 IN denotes to
T17787 35592-35600 VBN denotes measured
T17786 35555-35558 NNS denotes Abs
T17785 35554-35658 sentence denotes Abs to ssDNA and anti-chromatin were measured by ELISA, as previously described (Mitchell et al. 2002).
T17784 35553-35554 . denotes .
T17783 35545-35553 NN denotes endpoint
T17782 35542-35544 IN denotes to
T17781 35533-35541 VBN denotes titrated
T17780 35516-35524 JJ denotes positive
T17779 35525-35532 NNS denotes samples
T17778 35512-35515 DT denotes the
T17777 35508-35511 CC denotes and
T17776 35497-35498 -RRB- denotes )
T17775 35487-35497 JJ denotes anti-dsDNA
T17774 35486-35487 -LRB- denotes (
T17773 35483-35485 CD denotes 20
T17772 35482-35483 SYM denotes :
T17771 35481-35482 CD denotes 1
T17770 35478-35480 CC denotes or
T17769 35476-35477 -RRB- denotes )
T17768 35473-35476 NN denotes ANA
T17767 35472-35473 -LRB- denotes (
T17766 35469-35471 CD denotes 80
T17765 35468-35469 SYM denotes :
T17764 35467-35468 CD denotes 1
T17763 35499-35507 NN denotes dilution
T17762 35465-35466 DT denotes a
T17761 35462-35464 IN denotes at
T17760 35448-35452 VBD denotes were
T17759 35453-35461 VBN denotes screened
T17758 35440-35447 NNS denotes samples
T17757 35434-35439 NN denotes Serum
T17756 35433-35554 sentence denotes Serum samples were screened at a 1:80 (ANA) or 1:20 (anti-dsDNA) dilution and the positive samples titrated to endpoint.
T17755 35432-35433 . denotes .
T17754 35431-35432 -RRB- denotes )
T17753 35427-35431 CD denotes 2002
T17752 35423-35426 FW denotes al.
T17751 35420-35422 FW denotes et
T17750 35411-35419 NNP denotes Mitchell
T17749 35410-35411 -LRB- denotes (
T17748 35389-35399 RB denotes previously
T17747 35400-35409 VBN denotes described
T17746 35386-35388 IN denotes as
T17745 35377-35385 NNP denotes luciliae
T17744 35367-35376 NNP denotes Crithidia
T17743 35364-35366 IN denotes on
T17742 35345-35363 NN denotes immunofluorescence
T17741 35336-35344 JJ denotes indirect
T17740 35333-35335 IN denotes by
T17739 35319-35323 VBD denotes were
T17738 35324-35332 VBN denotes detected
T17737 35315-35318 NNS denotes Abs
T17736 35304-35314 JJ denotes anti-dsDNA
T17735 35300-35303 CC denotes and
T17734 35298-35300 , denotes ,
T17733 35291-35292 CD denotes 2
T17732 35290-35291 HYPH denotes -
T17731 35293-35298 NNS denotes cells
T17730 35287-35290 NN denotes Hep
T17729 35281-35286 VBG denotes using
T17728 35262-35280 NN denotes immunofluorescence
T17727 35253-35261 JJ denotes indirect
T17726 35250-35252 IN denotes by
T17725 35238-35242 VBD denotes were
T17724 35234-35237 NN denotes ANA
T17723 35230-35233 NN denotes IgG
T17722 35227-35229 IN denotes of
T17721 35243-35249 VBN denotes sought
T17720 35220-35226 NNS denotes Levels
T17719 35219-35433 sentence denotes Levels of IgG ANA were sought by indirect immunofluorescence using Hep-2 cells, and anti-dsDNA Abs were detected by indirect immunofluorescence on Crithidia luciliae as previously described (Mitchell et al. 2002).
T17718 35218-35219 . denotes .
T17717 35210-35218 NNS denotes auto-Abs
T17716 35207-35209 IN denotes of
T17715 35198-35206 NN denotes presence
T17714 35194-35197 DT denotes the
T17713 35190-35193 IN denotes for
T17712 35177-35181 VBD denotes were
T17711 35175-35177 , denotes ,
T17710 35172-35175 NN denotes age
T17709 35169-35171 IN denotes of
T17708 35163-35165 CD denotes 12
T17839 35836-35841 NN denotes mouse
T17838 35818-35820 DT denotes an
T17837 35813-35817 IN denotes from
T17836 35805-35812 VBN denotes derived
T17835 35804-35805 -LRB- denotes (
T17834 35788-35796 JJ denotes positive
T17833 35779-35787 JJ denotes standard
T17832 35797-35803 NN denotes sample
T17831 35777-35778 DT denotes a
T17830 35774-35776 IN denotes to
T17829 35765-35773 JJ denotes relative
T17828 35763-35764 -RRB- denotes )
T17827 35759-35763 NNS denotes AEUs
T17826 35758-35759 -LRB- denotes (
T17825 35746-35751 NNP denotes ELISA
T17824 35752-35757 NNS denotes units
T17823 35736-35745 JJ denotes arbitrary
T17822 35733-35735 IN denotes in
T17821 35718-35722 VBD denotes were
T17820 35723-35732 VBN denotes expressed
T17819 35710-35717 NNS denotes results
T17818 35706-35709 DT denotes the
T17817 35702-35705 CC denotes and
T17816 35700-35702 , denotes ,
T17815 35688-35691 CD denotes 100
T17814 35687-35688 SYM denotes :
T17813 35686-35687 CD denotes 1
T17812 35692-35700 NN denotes dilution
T17811 35684-35685 DT denotes a
T17810 35681-35683 IN denotes at
T17809 35667-35671 VBD denotes were
T17808 35672-35680 VBN denotes screened
T17807 35659-35666 NNS denotes Samples
T17806 35658-35878 sentence denotes Samples were screened at a 1:100 dilution, and the results were expressed in arbitrary ELISA units (AEUs) relative to a standard positive sample (derived from an MRL/Mp.lpr/lpr mouse), which was assigned a value of 100.
T17805 35657-35658 . denotes .
T17804 35656-35657 -RRB- denotes )
T17803 35652-35656 CD denotes 2002
T17802 35648-35651 FW denotes al.
T17801 35645-35647 FW denotes et
T17800 35636-35644 NNP denotes Mitchell
T17799 35635-35636 -LRB- denotes (
T17798 35614-35624 RB denotes previously
T17797 35625-35634 VBN denotes described
T17158 35103-35113 NNS denotes guidelines
T17157 35089-35102 JJ denotes institutional
T17156 35084-35088 IN denotes with
T17155 35073-35083 NN denotes accordance
T17154 35070-35072 IN denotes in
T17153 35065-35069 VBD denotes were
T17152 35047-35053 NN denotes animal
T17151 35054-35064 NNS denotes procedures
T17150 35043-35046 DT denotes All
T17149 35042-35114 sentence denotes All animal procedures were in accordance with institutional guidelines.
T17148 35041-35042 . denotes .
T17147 35025-35026 HYPH denotes -
T17146 35026-35030 JJ denotes free
T17145 35017-35025 NN denotes pathogen
T17144 35031-35041 NNS denotes conditions
T17143 35008-35016 JJ denotes specific
T17142 35005-35007 IN denotes in
T17141 34989-34993 VBD denotes were
T17140 34994-35004 VBN denotes maintained
T17139 34981-34988 NNS denotes Animals
T17138 34980-35042 sentence denotes Animals were maintained in specific pathogen-free conditions.
T17137 34979-34980 . denotes .
T17136 34976-34979 NN denotes age
T17135 34973-34975 IN denotes of
T17134 34971-34972 NN denotes y
T17133 34969-34970 CD denotes 1
T17132 34966-34968 IN denotes to
T17131 34963-34965 IN denotes up
T17130 34949-34953 VBD denotes were
T17129 34948-34949 SYM denotes −
T17128 34947-34948 HYPH denotes /
T17127 34946-34947 SYM denotes −
T17126 34934-34940 JJ denotes female
T17125 34932-34933 -RRB- denotes )
T17124 34929-34932 CD denotes 223
T17123 34928-34929 SYM denotes –
T17122 34920-34928 NN denotes D1Mit105
T17121 34919-34920 -LRB- denotes (
T17120 34916-34919 CD denotes 129
T17119 34915-34916 HYPH denotes .
T17118 34914-34915 CD denotes 6
T17117 34913-34914 HYPH denotes /
T17116 34908-34913 NN denotes C57BL
T17115 34941-34945 NNS denotes mice
T17114 34905-34907 CD denotes 26
T17113 34903-34905 , denotes ,
T17112 34890-34891 HYPH denotes -
T17111 34891-34895 NN denotes type
T17110 34886-34890 JJ denotes wild
T17109 34884-34885 CD denotes 6
T17108 34883-34884 HYPH denotes /
T17107 34878-34883 NN denotes C57BL
T17106 34896-34903 NNS denotes animals
T17105 34875-34877 CD denotes 30
T17104 34871-34874 CC denotes and
T17103 34865-34866 SYM denotes −
T17102 34864-34865 HYPH denotes /
T17101 34863-34864 SYM denotes −
T17100 34858-34862 NN denotes Apcs
T17099 34857-34858 HYPH denotes .
T17098 34856-34857 CD denotes 6
T17097 34855-34856 HYPH denotes /
T17096 34850-34855 NN denotes C57BL
T17095 34866-34870 NNS denotes mice
T17094 34847-34849 CD denotes 28
T17093 34842-34846 IN denotes with
T17092 34954-34962 VBN denotes followed
T17091 34836-34841 IN denotes Along
T17090 34835-34980 sentence denotes Along with 28 C57BL/6.Apcs −/−mice and 30 C57BL/6 wild-type animals, 26 C57BL/6.129(D1Mit105–223) female mice −/−were followed up to 1 y of age.
T17089 34834-34835 . denotes .
T17088 34833-34834 -RRB- denotes )
T17087 34825-34833 NN denotes D1Mit223
T17086 34824-34825 -LRB- denotes (
T17085 34821-34823 NN denotes cM
T17084 34817-34820 CD denotes 106
T17083 34813-34816 CC denotes and
T17082 34811-34812 -RRB- denotes )
T17081 34803-34811 NN denotes D1Mit159
T17080 34802-34803 -LRB- denotes (
T17079 34794-34798 CD denotes 81.6
T17078 34799-34801 NN denotes cM
T17077 34784-34793 NNS denotes positions
T17076 34781-34783 IN denotes at
T17075 34771-34772 CD denotes 6
T17074 34770-34771 HYPH denotes /
T17073 34765-34770 NN denotes C57BL
T17072 34757-34764 JJ denotes outside
T17071 34773-34780 NNS denotes markers
T17070 34753-34756 DT denotes the
T17069 34749-34752 CC denotes and
T17068 34747-34748 -RRB- denotes )
T17067 34739-34747 NN denotes D1Mit115
T17066 34738-34739 -LRB- denotes (
T17065 34735-34737 NN denotes cM
T17064 34730-34734 CD denotes 99.7
T17063 34726-34729 CC denotes and
T17062 34724-34725 -RRB- denotes )
T17061 34717-34724 NN denotes D1Mit36
T17060 34716-34717 -LRB- denotes (
T17059 34710-34712 CD denotes 93
T17058 34713-34715 NN denotes cM
T17057 34700-34709 NNS denotes positions
T17056 34697-34699 IN denotes at
T17055 34680-34683 CD denotes 129
T17054 34673-34679 JJ denotes inside
T17053 34684-34691 NNS denotes markers
T17052 34669-34672 DT denotes the
T17051 34667-34669 , denotes ,
T17050 34659-34667 NN denotes analysis
T17049 34654-34658 DT denotes this
T17048 34692-34696 VBD denotes were
T17047 34651-34653 IN denotes In
T17046 34650-34835 sentence denotes In this analysis, the inside 129 markers were at positions 93 cM (D1Mit36) and 99.7 cM (D1Mit115) and the outside C57BL/6 markers at positions 81.6 cM (D1Mit159) and 106 cM (D1Mit223).
T17045 34649-34650 . denotes .
T17044 34648-34649 -RRB- denotes )
T17043 34641-34648 NN denotes D1Mit17
T17042 34640-34641 -LRB- denotes (
T17041 34637-34639 NN denotes cM
T17026 34568-34571 DT denotes the
T17025 34561-34567 IN denotes around
T17024 34550-34553 CD denotes 129
T17023 34554-34560 NN denotes genome
T17022 34546-34549 DT denotes the
T17021 34544-34546 , denotes ,
T17020 34543-34544 -RRB- denotes )
T17019 34532-34543 NNS denotes generations
T17018 34528-34531 CD denotes ten
T17017 34524-34527 IN denotes for
T17016 34522-34523 CD denotes 6
T17015 34521-34522 HYPH denotes /
T17014 34516-34521 NN denotes C57BL
T17013 34511-34515 IN denotes onto
T17012 34499-34510 VBN denotes backcrossed
T17011 34498-34499 -LRB- denotes (
T17010 34491-34492 SYM denotes −
T17009 34490-34491 HYPH denotes /
T17008 34489-34490 SYM denotes −
T17007 34484-34488 NN denotes Apcs
T17006 34483-34484 HYPH denotes .
T17005 34482-34483 CD denotes 6
T17004 34481-34482 HYPH denotes /
T17003 34476-34481 NN denotes C57BL
T17002 34493-34497 NNS denotes mice
T17001 34472-34475 DT denotes the
T17000 34587-34593 VBN denotes mapped
T16999 34469-34471 IN denotes In
T16998 34468-34650 sentence denotes In the C57BL/6.Apcs −/− mice (backcrossed onto C57BL/6 for ten generations), the 129 genome around the Apcs locus was mapped as a segment from 87.9 cM (D1Mit15) to 105 cM (D1Mit17).
T16997 34467-34468 . denotes .
T16996 34459-34467 NN denotes interval
T16995 34455-34458 DT denotes the
T16994 34440-34447 RB denotes further
T16993 34448-34454 VB denotes define
T16992 34437-34439 TO denotes to
T16991 34427-34431 VBD denotes were
T16990 34425-34426 -RRB- denotes )
T16989 34417-34425 NN denotes D1Mit159
T16988 34416-34417 -LRB- denotes (
T16987 34409-34415 NN denotes 74.3cM
T16986 34400-34408 NN denotes position
T16985 34397-34399 IN denotes at
T16984 34388-34389 CD denotes 6
T16983 34387-34388 HYPH denotes /
T16982 34382-34387 NN denotes C57BL
T16981 34374-34381 JJ denotes outside
T16980 34390-34396 NN denotes marker
T16979 34371-34373 DT denotes an
T16978 34367-34370 CC denotes and
T16977 34365-34367 , denotes ,
T16976 34353-34365 RB denotes respectively
T16975 34351-34353 , denotes ,
T16974 34350-34351 -RRB- denotes )
T16973 34343-34350 NN denotes D1Mit17
T16972 34342-34343 -LRB- denotes (
T16971 34339-34341 NN denotes cM
T16970 34335-34338 CD denotes 105
T16969 34331-34334 CC denotes and
T16968 34329-34330 -RRB- denotes )
T16967 34321-34329 NN denotes D1Mit159
T16966 34320-34321 -LRB- denotes (
T16965 34312-34316 CD denotes 81.6
T16964 34317-34319 NN denotes cM
T16963 34302-34311 NNS denotes positions
T16962 34299-34301 IN denotes at
T16961 34432-34436 VBN denotes used
T16960 34287-34290 CD denotes 129
T16959 34291-34298 NNS denotes markers
T16958 34280-34286 JJ denotes Inside
T16957 34279-34468 sentence denotes Inside 129 markers at positions 81.6 cM (D1Mit159) and 105 cM (D1Mit17), respectively, and an outside C57BL/6 marker at position 74.3cM (D1Mit159) were used to further define the interval.
T16956 34278-34279 . denotes .
T16955 34268-34269 CD denotes 1
T16954 34257-34267 NN denotes Chromosome
T16953 34253-34256 CD denotes 129
T16952 34270-34278 NN denotes interval
T16951 34249-34252 DT denotes the
T16950 34245-34248 IN denotes for
T16949 34234-34244 JJ denotes homozygous
T16948 34220-34228 JJ denotes congenic
T16947 34218-34219 -RRB- denotes )
T16946 34215-34218 CD denotes 223
T16945 34214-34215 SYM denotes –
T16944 34206-34214 NN denotes D1Mit105
T16943 34205-34206 -LRB- denotes (
T16942 34202-34205 CD denotes 129
T16941 34201-34202 HYPH denotes .
T16940 34200-34201 CD denotes 6
T16939 34199-34200 HYPH denotes /
T16938 34229-34233 NNS denotes mice
T16937 34194-34199 NN denotes C57BL
T16936 34185-34193 VB denotes generate
T16935 34182-34184 TO denotes to
T16934 34164-34168 VBD denotes were
T16933 34155-34163 NNS denotes siblings
T16932 34153-34155 , denotes ,
T16931 34141-34153 VBG denotes backcrossing
T16930 34138-34140 IN denotes of
T16929 34126-34137 NNS denotes generations
T16928 34120-34125 CD denotes seven
T16927 34169-34181 VBN denotes intercrossed
T16926 34114-34119 IN denotes After
T16925 34113-34279 sentence denotes After seven generations of backcrossing, siblings were intercrossed to generate C57BL/6.129(D1Mit105–223) congenic mice homozygous for the 129 Chromosome 1 interval.
T16924 34112-34113 . denotes .
T16923 34111-34112 -RRB- denotes )
T16922 34106-34111 RB denotes below
T16921 34102-34105 VB denotes see
T16920 34101-34102 -LRB- denotes (
T16919 34094-34095 CD denotes 6
T16918 34093-34094 HYPH denotes /
T16917 34088-34093 NN denotes C57BL
T16916 34084-34087 CC denotes and
T16915 34096-34100 NNS denotes mice
T16914 34080-34083 CD denotes 129
T16913 34072-34079 IN denotes between
T16912 34060-34071 JJ denotes polymorphic
T16911 34052-34059 NNS denotes markers
T16910 34037-34051 NN denotes microsatellite
T16909 34032-34036 IN denotes with
T16908 34020-34024 VBD denotes were
T16907 34025-34031 VBN denotes mapped
T16906 34008-34011 CD denotes 129
T16905 34012-34019 NNS denotes regions
T16904 33998-34007 VBN denotes Inherited
T16903 33997-34113 sentence denotes Inherited 129 regions were mapped with microsatellite markers polymorphic between 129 and C57BL/6 mice (see below).
T16902 33996-33997 . denotes .
T16901 33988-33989 CD denotes 6
T16900 33987-33988 HYPH denotes /
T16899 33982-33987 NN denotes C57BL
T16898 33990-33996 NN denotes strain
T16897 33978-33981 DT denotes the
T16896 33973-33977 IN denotes onto
T16895 33971-33972 -RRB- denotes )
T16894 33969-33971 NN denotes cM
T16893 33965-33968 CD denotes 106
T16892 33962-33964 IN denotes to
T16891 33956-33958 CD denotes 80
T16890 33959-33961 NN denotes cM
T16889 33955-33956 -LRB- denotes (
T16888 33946-33954 NN denotes D1Mit223
T16887 33942-33945 CC denotes and
T16886 33933-33941 NN denotes D1Mit105
T16885 33917-33932 NNS denotes microsatellites
T16884 33909-33916 IN denotes between
T16883 33896-33899 CD denotes 129
T16882 33900-33908 NN denotes interval
T16881 33892-33895 DT denotes the
T16880 33879-33891 VBG denotes backcrossing
T16879 33876-33878 IN denotes by
T16878 33861-33865 VBD denotes were
T16877 33866-33875 VBN denotes generated
T16876 33854-33855 -RRB- denotes )
T16875 33851-33854 CD denotes 223
T16874 33850-33851 SYM denotes –
T16873 33842-33850 NN denotes D1Mit105
T16872 33841-33842 -LRB- denotes (
T16871 33838-33841 CD denotes 129
T16870 33837-33838 HYPH denotes .
T16869 33836-33837 CD denotes 6
T16868 33835-33836 HYPH denotes /
T16867 33830-33835 NN denotes C57BL
T16866 33821-33829 JJ denotes congenic
T16865 33856-33860 NNS denotes mice
T16864 33815-33816 HYPH denotes -
T16863 33816-33820 NN denotes type
T16862 33811-33815 JJ denotes Wild
T16861 33810-33997 sentence denotes Wild-type congenic C57BL/6.129(D1Mit105–223) mice were generated by backcrossing the 129 interval between microsatellites D1Mit105 and D1Mit223 (80 cM to 106 cM) onto the C57BL/6 strain.
T16860 33809-33810 . denotes .
T16859 33808-33809 NN denotes y
T16858 33806-33807 CD denotes 1
T16857 33802-33805 IN denotes for
T16856 33792-33801 VBN denotes monitored
T16855 33788-33791 CC denotes and
T16854 33774-33778 VBD denotes were
T16853 33762-33768 JJ denotes female
T16852 33760-33761 SYM denotes −
T16851 33759-33760 HYPH denotes /
T16850 33758-33759 SYM denotes −
T16849 33753-33757 NN denotes Apcs
T16848 33752-33753 HYPH denotes .
T16847 33769-33773 NNS denotes mice
T16846 33749-33750 -RRB- denotes )
T16845 33748-33749 CD denotes 6
T16844 33747-33748 HYPH denotes /
T16843 33740-33741 SYM denotes ×
T16842 33742-33747 NN denotes C57BL
T16841 33736-33739 CD denotes 129
T16840 33735-33736 -LRB- denotes (
T16839 33750-33752 NN denotes F2
T16838 33731-33734 CD denotes 158
T16837 33727-33730 CC denotes and
T16836 33723-33724 -RRB- denotes )
T16835 33722-33723 CD denotes 6
T16834 33721-33722 HYPH denotes /
T16833 33716-33721 NN denotes C57BL
T16832 33714-33715 SYM denotes ×
T16831 33710-33713 CD denotes 129
T16830 33709-33710 -LRB- denotes (
T16829 33724-33726 NN denotes F2
T16828 33705-33708 CD denotes 141
T16827 33702-33704 IN denotes of
T16826 33779-33787 VBN denotes produced
T16825 33696-33701 NN denotes total
T16824 33694-33695 DT denotes A
T16823 33693-33810 sentence denotes A total of 141 (129 × C57BL/6)F2 and 158 (129 × C57BL/6)F2.Apcs −/− female mice were produced and monitored for 1 y.
T16822 33692-33693 . denotes .
T16821 33681-33692 NNS denotes generations
T16820 33677-33680 CD denotes ten
T16819 33673-33676 IN denotes for
T16818 33671-33672 CD denotes 6
T16817 33670-33671 HYPH denotes /
T16816 33665-33670 NN denotes C57BL
T16815 33660-33664 IN denotes onto
T16814 33648-33659 VBN denotes backcrossed
T16813 33638-33639 SYM denotes −
T16812 33637-33638 HYPH denotes /
T16811 33636-33637 SYM denotes −
T16753 33417-33422 NN denotes C57BL
T16752 33415-33416 SYM denotes ×
T16751 33411-33414 CD denotes 129
T16750 33410-33411 -LRB- denotes (
T16749 33428-33432 NNS denotes mice
T16748 33406-33409 DT denotes the
T16747 33392-33405 VBG denotes interbreeding
T16746 33389-33391 IN denotes by
T16745 33381-33383 NN denotes F2
T16744 33380-33381 -RRB- denotes )
T16743 33379-33380 CD denotes 6
T16742 33378-33379 HYPH denotes /
T16741 33373-33378 NN denotes C57BL
T16740 33371-33372 SYM denotes ×
T16739 33367-33370 CD denotes 129
T16738 33384-33388 NNS denotes mice
T16737 33366-33367 -LRB- denotes (
T16736 33362-33365 CC denotes and
T16735 33348-33349 HYPH denotes -
T16734 33349-33353 NN denotes type
T16733 33344-33348 JJ denotes wild
T16732 33340-33343 CD denotes two
T16731 33354-33361 NNS denotes strains
T16730 33336-33339 DT denotes the
T16729 33322-33335 VBG denotes intercrossing
T16728 33319-33321 IN denotes by
T16727 33304-33308 VBD denotes were
T16726 33309-33318 VBN denotes generated
T16725 33296-33298 NN denotes F1
T16724 33295-33296 -RRB- denotes )
T16723 33294-33295 CD denotes 6
T16722 33293-33294 HYPH denotes /
T16721 33288-33293 NN denotes C57BL
T16720 33286-33287 SYM denotes ×
T16719 33282-33285 CD denotes 129
T16718 33299-33303 NNS denotes mice
T16717 33281-33282 -LRB- denotes (
T16716 33280-33433 sentence denotes (129 × C57BL/6)F1 mice were generated by intercrossing the two wild-type strains and (129 × C57BL/6)F2 mice by interbreeding the (129 × C57BL/6)F1 mice.
T16715 33279-33280 . denotes .
T16714 33272-33279 NNP denotes Kingdom
T16713 33265-33271 NNP denotes United
T16712 33263-33265 , denotes ,
T16711 33257-33263 NNP denotes London
T16710 33255-33257 , denotes ,
T16709 33248-33255 NNP denotes College
T16708 33239-33247 NNP denotes Imperial
T16707 33236-33238 IN denotes at
T16706 33222-33226 NN denotes care
T16705 33215-33221 NN denotes animal
T16704 33227-33235 NN denotes facility
T16703 33211-33214 DT denotes the
T16702 33208-33210 IN denotes in
T16701 33197-33207 VBN denotes maintained
T16700 33193-33196 CC denotes and
T16699 33183-33187 VBD denotes were
T16698 33181-33182 -RRB- denotes )
T16697 33161-33168 VBN denotes revised
T16696 33169-33181 NN denotes nomenclature
T16695 33157-33160 DT denotes the
T16694 33154-33156 IN denotes to
T16693 33144-33153 VBG denotes according
T16692 33142-33144 , denotes ,
T16691 33137-33142 NN denotes 129S6
T16690 33136-33137 -LRB- denotes (
T16689 33132-33133 HYPH denotes /
T16688 33133-33135 NN denotes Sv
T16687 33129-33132 NN denotes 129
T16686 33125-33128 CC denotes and
T16685 33123-33124 CD denotes 6
T16684 33122-33123 HYPH denotes /
T16683 33117-33122 NN denotes C57BL
T16682 33188-33192 VBN denotes bred
T16681 33111-33112 HYPH denotes -
T16680 33112-33116 NN denotes type
T16679 33107-33111 JJ denotes Wild
T17040 34633-34636 CD denotes 105
T17039 34630-34632 IN denotes to
T17038 34628-34629 -RRB- denotes )
T17037 34621-34628 NN denotes D1Mit15
T17036 34620-34621 -LRB- denotes (
T17035 34617-34619 NN denotes cM
T17034 34612-34616 CD denotes 87.9
T17033 34607-34611 IN denotes from
T17032 34599-34606 NN denotes segment
T17031 34597-34598 DT denotes a
T17030 34594-34596 IN denotes as
T17029 34583-34586 VBD denotes was
T17028 34572-34576 NN denotes Apcs
T17027 34577-34582 NN denotes locus
T16678 33106-33280 sentence denotes Wild-type C57BL/6 and 129/Sv (129S6, according to the revised nomenclature) were bred and maintained in the animal care facility at Imperial College, London, United Kingdom.
T16677 33105-33106 . denotes .
T16676 33098-33105 NNS denotes females
T16675 33093-33097 VBD denotes were
T16674 33084-33087 DT denotes the
T16673 33088-33092 NNS denotes mice
T16672 33080-33083 PDT denotes All
T16671 33079-33106 sentence denotes All the mice were females.
T16670 33078-33079 . denotes .
T16669 33074-33078 NNS denotes Mice
T16810 33640-33647 NNS denotes animals
T16809 33631-33635 NN denotes Apcs
T16808 33626-33630 IN denotes with
T16807 33607-33614 JJ denotes genetic
T16806 33603-33606 CD denotes 129
T16805 33615-33625 NN denotes background
T16804 33599-33602 DT denotes the
T16803 33596-33598 IN denotes on
T16802 33589-33590 SYM denotes −
T16801 33588-33589 HYPH denotes /
T16800 33587-33588 SYM denotes −
T16799 33591-33595 NNS denotes mice
T16798 33582-33586 NNP denotes Apcs
T16797 33568-33581 VBG denotes intercrossing
T16796 33565-33567 IN denotes by
T16795 33550-33554 VBD denotes were
T16794 33555-33564 VBN denotes generated
T16793 33543-33544 SYM denotes −
T16792 33542-33543 HYPH denotes /
T16791 33541-33542 SYM denotes −
T16790 33536-33540 NN denotes Apcs
T16789 33535-33536 HYPH denotes .
T16788 33532-33533 -RRB- denotes )
T16787 33531-33532 CD denotes 6
T16786 33530-33531 HYPH denotes /
T16785 33525-33530 NN denotes C57BL
T16784 33523-33524 SYM denotes ×
T16783 33519-33522 CD denotes 129
T16782 33533-33535 NN denotes F2
T16781 33518-33519 -LRB- denotes (
T16780 33545-33549 NNS denotes mice
T16779 33514-33517 DT denotes the
T16778 33510-33513 CC denotes and
T16777 33508-33510 , denotes ,
T16776 33507-33508 -RRB- denotes )
T16775 33503-33507 CD denotes 1997
T16774 33499-33502 FW denotes al.
T16773 33496-33498 FW denotes et
T16772 33490-33495 NNP denotes Botto
T16771 33489-33490 -LRB- denotes (
T16770 33469-33479 RB denotes previously
T16769 33480-33488 VBN denotes reported
T16768 33466-33468 IN denotes as
T16767 33451-33455 VBD denotes were
T16766 33456-33465 VBN denotes generated
T16765 33445-33446 SYM denotes −
T16764 33444-33445 HYPH denotes /
T16763 33443-33444 SYM denotes −
T16762 33438-33442 NN denotes Apcs
T16761 33446-33450 NNS denotes mice
T16760 33434-33437 DT denotes The
T16759 33433-33693 sentence denotes The Apcs −/−mice were generated as previously reported (Botto et al. 1997), and the (129 × C57BL/6)F2.Apcs −/− mice were generated by intercrossing Apcs −/− mice on the 129 genetic background with Apcs −/− animals backcrossed onto C57BL/6 for ten generations.
T16758 33432-33433 . denotes .
T16757 33425-33427 NN denotes F1
T16756 33424-33425 -RRB- denotes )
T16755 33423-33424 CD denotes 6
T16754 33422-33423 HYPH denotes /
T15730 33029-33036 JJ denotes genetic
T15729 33037-33048 NNS denotes disruptions
T15728 33020-33028 JJ denotes specific
T15727 33017-33019 IN denotes of
T15726 32996-33006 JJ denotes autoimmune
T15725 33007-33016 NN denotes phenotype
T15724 32992-32995 DT denotes the
T15723 32982-32991 VBG denotes analysing
T15722 32977-32981 WRB denotes when
T15721 32961-32976 NNS denotes interpretations
T15720 32951-32960 JJ denotes incorrect
T15719 32948-32950 IN denotes to
T15718 32939-32942 MD denotes may
T15717 32926-32930 NN denotes gene
T15716 32915-32925 NN denotes background
T15715 32931-32938 NNS denotes effects
T15714 32909-32914 DT denotes these
T15713 32943-32947 VB denotes lead
T15712 32905-32908 WRB denotes how
T15711 32894-32904 VBP denotes illustrate
T15710 32890-32893 CC denotes and
T15709 32886-32889 NN denotes SLE
T15708 32883-32885 IN denotes of
T15707 32871-32882 NN denotes development
T15706 32867-32870 DT denotes the
T15705 32864-32866 IN denotes on
T15704 32854-32855 CD denotes 6
T15703 32853-32854 HYPH denotes /
T15702 32856-32863 NNS denotes genomes
T15701 32844-32847 CC denotes and
T15700 32848-32853 NN denotes C57BL
T15699 32840-32843 CD denotes 129
T15698 32832-32839 IN denotes between
T15697 32819-32831 NNS denotes interactions
T15696 32809-32818 JJ denotes epistatic
T15695 32806-32808 IN denotes of
T15694 32799-32805 NN denotes impact
T15693 32795-32798 DT denotes the
T15692 32774-32782 NNS denotes findings
T15691 32770-32773 PRP$ denotes our
T15690 32768-32770 , denotes ,
T15689 32761-32768 NN denotes summary
T15688 32783-32794 VBP denotes demonstrate
T15687 32758-32760 IN denotes In
T15686 32757-33049 sentence denotes In summary, our findings demonstrate the impact of epistatic interactions between 129 and C57BL/6 genomes on the development of SLE and illustrate how these background gene effects may lead to incorrect interpretations when analysing the autoimmune phenotype of specific genetic disruptions.
T15685 32756-32757 . denotes .
T15684 32750-32756 NN denotes damage
T15683 32744-32749 JJ denotes renal
T15682 32741-32743 IN denotes of
T15681 32728-32740 NN denotes pathogenesis
T15680 32724-32727 DT denotes the
T15679 32721-32723 IN denotes in
T15678 32716-32720 NN denotes Apcs
T15677 32713-32715 IN denotes of
T15676 32708-32712 NN denotes role
T15462 31612-31621 VBN denotes suggested
T15461 31586-31588 IN denotes as
T15460 31584-31586 , denotes ,
T15459 31572-31584 NNS denotes autoantigens
T15458 31569-31571 IN denotes of
T15457 31558-31568 NN denotes processing
T15456 31554-31557 DT denotes the
T15455 31551-31553 IN denotes in
T15454 31536-31539 RB denotes not
T15453 31533-31535 VBZ denotes is
T15452 31528-31532 NN denotes Apcs
T15451 31540-31550 VBN denotes implicated
T15450 31523-31527 IN denotes that
T15449 31628-31636 VBP denotes indicate
T15448 31502-31510 NNS denotes findings
T15447 31496-31501 DT denotes these
T15446 31511-31522 VBP denotes demonstrate
T15445 31487-31495 IN denotes Although
T15444 31486-31712 sentence denotes Although these findings demonstrate that Apcs is not implicated in the processing of autoantigens, as it had previously been suggested, they indicate that Apcs might still play an important protective role in lupus nephritis.
T15443 31485-31486 . denotes .
T15442 31472-31480 JJ denotes congenic
T15441 31481-31485 NNS denotes mice
T15440 31468-31471 DT denotes the
T15439 31463-31467 IN denotes with
T15438 31454-31462 VBN denotes compared
T15437 31447-31448 SYM denotes −
T15436 31446-31447 HYPH denotes /
T15435 31445-31446 SYM denotes −
T15434 31441-31445 NN denotes Apcs
T15433 31449-31453 NNS denotes mice
T15432 31437-31440 DT denotes the
T15431 31434-31436 IN denotes in
T15430 31423-31433 JJ denotes pronounced
T15429 31418-31422 RBR denotes more
T15428 31414-31417 VBD denotes was
T15427 31408-31413 WDT denotes which
T15426 31406-31408 , denotes ,
T15425 31388-31406 NN denotes glomerulonephritis
T15424 31385-31387 IN denotes of
T15423 31374-31384 NN denotes expression
T15422 31370-31373 DT denotes the
T15421 31367-31369 IN denotes in
T15420 31358-31362 NNS denotes mice
T15419 31352-31357 DT denotes these
T15418 31344-31351 IN denotes between
T15417 31334-31343 NN denotes phenotype
T15416 31331-31333 IN denotes in
T15415 31363-31366 VBD denotes was
T15414 31315-31319 JJ denotes only
T15413 31320-31330 NN denotes difference
T15412 31311-31314 DT denotes The
T15411 31310-31486 sentence denotes The only difference in phenotype between these mice was in the expression of glomerulonephritis, which was more pronounced in the Apcs−/− mice compared with the congenic mice.
T15410 31309-31310 . denotes .
T15409 31305-31309 NNS denotes mice
T15408 31303-31304 SYM denotes −
T15407 31302-31303 HYPH denotes /
T15406 31301-31302 SYM denotes −
T15405 31297-31301 NN denotes Apcs
T15404 31293-31296 DT denotes the
T15403 31288-31292 IN denotes with
T15402 31279-31287 JJ denotes congenic
T15401 31275-31278 DT denotes the
T15400 31265-31274 VBG denotes comparing
T15399 31255-31264 JJ denotes identical
T15398 31238-31250 NN denotes autoimmunity
T15397 31225-31237 JJ denotes anti-nuclear
T15396 31222-31224 IN denotes of
T15395 31251-31254 VBD denotes was
T15394 31211-31221 NN denotes expression
T15393 31207-31210 DT denotes The
T15392 31206-31310 sentence denotes The expression of anti-nuclear autoimmunity was identical comparing the congenic with the Apcs−/− mice.
T15391 31205-31206 . denotes .
T15390 31204-31205 -RRB- denotes )
T15389 31200-31204 CD denotes 1999
T15388 31198-31200 , denotes ,
T15387 31194-31198 CD denotes 1996
T15386 31190-31193 FW denotes al.
T15385 31187-31189 FW denotes et
T15384 31179-31186 NNP denotes O'Keefe
T15383 31178-31179 -LRB- denotes (
T15382 31176-31177 CD denotes 7
T15381 31165-31175 NN denotes Chromosome
T15380 31162-31164 IN denotes on
T15379 31140-31154 NN denotes susceptibility
T15378 31131-31132 HYPH denotes -
T15377 31132-31139 VBN denotes derived
T15376 31128-31131 CD denotes 129
T15375 31155-31161 NN denotes allele
T15374 31124-31127 DT denotes the
T15373 31121-31123 IN denotes in
T15372 31114-31120 VBN denotes mapped
T15371 31108-31113 NNS denotes genes
T15370 31105-31107 IN denotes of
T15369 31095-31104 NNS denotes mutations
T15368 31086-31094 VBG denotes carrying
T15367 31068-31069 HYPH denotes -
T15366 31069-31077 VBN denotes targeted
T15365 31064-31068 NN denotes gene
T15364 31078-31085 NNS denotes animals
T15363 31058-31063 JJ denotes other
T15362 31055-31057 IN denotes to
T15361 31045-31048 MD denotes may
T15360 31049-31054 VB denotes apply
T15359 31033-31044 NNS denotes conclusions
T15358 31025-31032 JJ denotes Similar
T15357 31024-31206 sentence denotes Similar conclusions may apply to other gene-targeted animals carrying mutations of genes mapped in the 129-derived susceptibility allele on Chromosome 7 (O'Keefe et al. 1996, 1999).
T15356 31023-31024 . denotes .
T15355 31013-31023 JJ denotes irrelevant
T15354 30998-31002 JJ denotes null
T15353 30989-30997 VBN denotes targeted
T15352 31003-31007 NN denotes gene
T15351 30985-30988 DT denotes the
T15350 30982-30984 IN denotes of
T15349 30974-30981 NNS denotes effects
T15348 30970-30973 DT denotes the
T15347 30968-30970 , denotes ,
T15346 30965-30968 NN denotes SLE
T15345 30962-30964 IN denotes of
T15344 30948-30954 JJ denotes murine
T15343 30955-30961 NNS denotes models
T15342 30942-30947 DT denotes these
T15341 30939-30941 IN denotes of
T15340 30934-30938 DT denotes each
T15339 30931-30933 IN denotes in
T15338 31008-31012 VBD denotes were
T15337 30926-30930 IN denotes that
T15336 30912-30915 MD denotes may
T15335 30908-30911 PRP denotes one
T15334 30906-30908 , denotes ,
T15333 30898-30906 NNS denotes findings
T15332 30894-30897 PRP$ denotes our
T15331 30891-30893 IN denotes of
T15330 30886-30890 NN denotes view
T15329 30883-30885 IN denotes in
T15328 30881-30883 , denotes ,
T15327 30916-30925 VB denotes postulate
T15326 30877-30881 RB denotes Thus
T15325 30876-31024 sentence denotes Thus, in view of our findings, one may postulate that in each of these murine models of SLE, the effects of the targeted null gene were irrelevant.
T15324 30875-30876 . denotes .
T15323 30857-30864 JJ denotes genetic
T15322 30865-30875 NN denotes background
T15321 30849-30856 DT denotes another
T15320 30846-30848 CC denotes or
T15319 30844-30845 CD denotes 6
T15318 30843-30844 HYPH denotes /
T15317 30838-30843 NN denotes C57BL
T15316 30834-30837 DT denotes the
T15315 30831-30833 IN denotes to
T15314 30819-30830 VBD denotes backcrossed
T15313 30814-30818 RB denotes then
T15312 30810-30813 CC denotes and
T15311 30799-30803 NN denotes stem
T15310 30789-30798 JJ denotes embryonic
T15309 30804-30809 NNS denotes cells
T15308 30785-30788 CD denotes 129
T15307 30782-30784 IN denotes in
T15306 30768-30771 VBD denotes was
T15305 30754-30758 JJ denotes null
T15304 30759-30767 NN denotes mutation
T15303 30750-30753 DT denotes the
T15302 30744-30749 WDT denotes which
T15301 30772-30781 VBN denotes generated
T15300 30741-30743 IN denotes in
T15299 30736-30740 NNS denotes mice
T15298 30733-30735 IN denotes in
T15297 30719-30722 VBD denotes was
T15296 30698-30708 JJ denotes autoimmune
T15295 30709-30718 NN denotes phenotype
T15294 30694-30697 DT denotes the
T15293 30692-30694 , denotes ,
T15292 30688-30692 NN denotes case
T15291 30683-30687 DT denotes each
T15290 30723-30732 VBN denotes described
T15289 30680-30682 IN denotes In
T15288 30679-30876 sentence denotes In each case, the autoimmune phenotype was described in mice in which the null mutation was generated in 129 embryonic stem cells and then backcrossed to the C57BL/6 or another genetic background.
T15287 30678-30679 . denotes .
T15286 30677-30678 -RRB- denotes )
T15285 30673-30677 CD denotes 2002
T15284 30669-30672 FW denotes al.
T15283 30666-30668 FW denotes et
T15282 30661-30665 NNP denotes Miwa
T15281 30660-30661 -LRB- denotes (
T15280 30658-30659 -RRB- denotes )
T15279 30654-30658 NN denotes CD55
T15278 30653-30654 -LRB- denotes (
T15277 30646-30652 NN denotes factor
T15276 30632-30633 HYPH denotes -
T15275 30633-30645 VBG denotes accelerating
T15274 30627-30632 NN denotes decay
T15273 30623-30626 CC denotes and
T15272 30621-30623 , denotes ,
T15271 30620-30621 -RRB- denotes )
T15270 30616-30620 CD denotes 2002
T15269 30612-30615 FW denotes al.
T15268 30609-30611 FW denotes et
T15267 30606-30608 NNP denotes Wu
T15266 30604-30605 : denotes ;
T15265 30600-30604 CD denotes 1998
T15264 30596-30599 FW denotes al.
T15263 30593-30595 FW denotes et
T15262 30585-30592 NNP denotes Prodeus
T15261 30584-30585 -LRB- denotes (
T15260 30582-30583 -RRB- denotes )
T15259 30581-30582 CD denotes 2
T15258 30580-30581 HYPH denotes /
T15257 30577-30580 NN denotes CR1
T15256 30576-30577 -LRB- denotes (
T15255 30566-30575 NNS denotes receptors
T15254 30555-30565 NN denotes complement
T15253 30553-30555 , denotes ,
T15252 30552-30553 -RRB- denotes )
T15251 30548-30552 CD denotes 2000
T15250 30540-30547 NNP denotes Ravetch
T15249 30536-30539 CC denotes and
T15248 30528-30535 NNP denotes Bolland
T15247 30527-30528 -LRB- denotes (
T14782 28103-28105 IN denotes to
T14781 28098-28102 RB denotes also
T14780 28094-28097 CC denotes and
T14779 28092-28093 -RRB- denotes )
T14778 28088-28092 CD denotes 1990
T14777 28084-28087 FW denotes al.
T14776 28081-28083 FW denotes et
T14775 28074-28080 NNP denotes Butler
T14774 28072-28073 : denotes ;
T14773 28068-28072 CD denotes 1987
T14772 28061-28067 NNP denotes Butler
T14771 28057-28060 CC denotes and
T14770 28051-28056 NNP denotes Pepys
T14769 28049-28050 : denotes ;
T14768 28045-28049 CD denotes 1974
T14767 28039-28044 NNP denotes Pepys
T14766 28038-28039 -LRB- denotes (
T14765 28032-28037 FW denotes vitro
T14764 28029-28031 FW denotes in
T14763 28018-28028 NNS denotes conditions
T14762 28004-28017 JJ denotes physiological
T14761 28001-28003 IN denotes in
T14760 27995-28000 NNS denotes cells
T14759 27985-27994 JJ denotes apoptotic
T14758 27981-27984 CC denotes and
T14757 27979-27981 , denotes ,
T14756 27970-27979 NN denotes chromatin
T14755 27968-27970 , denotes ,
T14754 27965-27968 NN denotes DNA
T14753 27962-27964 IN denotes to
T14752 27955-27961 RB denotes avidly
T14751 27949-27954 VBZ denotes binds
T14750 27929-27936 NN denotes amyloid
T14749 27937-27938 NN denotes P
T14748 27923-27928 NN denotes serum
T14747 27917-27922 JJ denotes human
T14746 27939-27948 NN denotes component
T14745 27913-27916 DT denotes The
T14744 27912-28220 sentence denotes The human serum amyloid P component binds avidly to DNA, chromatin, and apoptotic cells in physiological conditions in vitro (Pepys 1974; Pepys and Butler 1987; Butler et al. 1990) and also to exposed chromatin and apoptotic cells in vivo (Hintner et al. 1988; Breathnach et al. 1989; Familian et al. 2001).
T14743 27911-27912 . denotes .
T14742 27905-27911 NN denotes region
T14741 27900-27904 DT denotes this
T14740 27893-27899 IN denotes within
T14739 27889-27892 VB denotes lie
T14738 27886-27888 TO denotes to
T14737 27880-27885 VBN denotes known
T14736 27864-27873 NN denotes candidate
T14735 27874-27879 NNS denotes genes
T14734 27860-27863 DT denotes the
T14733 27857-27859 IN denotes of
T14732 27853-27856 CD denotes one
T14731 27850-27852 VBZ denotes is
T14730 27840-27844 NN denotes Apcs
T14729 27845-27849 NN denotes gene
T14728 27836-27839 DT denotes The
T14727 27835-27912 sentence denotes The Apcs gene is one of the candidate genes known to lie within this region.
T14726 27834-27835 . denotes .
T14725 27833-27834 -RRB- denotes )
T14724 27829-27833 CD denotes 1998
T14723 27825-27828 FW denotes al.
T14722 27822-27824 FW denotes et
T14721 27816-27821 NNP denotes Moser
T14720 27815-27816 -LRB- denotes (
T14719 27811-27814 NN denotes SLE
T14718 27805-27810 JJ denotes human
T14717 27800-27804 IN denotes with
T14716 27788-27792 VBN denotes been
T14715 27783-27787 RB denotes also
T14714 27779-27782 VBZ denotes has
T14713 27793-27799 VBN denotes linked
T14712 27773-27778 WDT denotes which
T14711 27771-27773 , denotes ,
T14710 27767-27771 NN denotes 1q25
T14709 27766-27767 SYM denotes –
T14708 27751-27761 NN denotes Chromosome
T15652 32542-32550 JJ denotes congenic
T15651 32551-32555 NNS denotes mice
T15650 32538-32541 DT denotes the
T15649 32535-32537 IN denotes in
T15648 32525-32534 NN denotes nephritis
T15647 32519-32524 NN denotes lupus
T15646 32516-32518 IN denotes of
T15645 32511-32515 NN denotes lack
T15644 32507-32510 DT denotes the
T15643 32556-32558 VBZ denotes is
T15642 32500-32506 IN denotes whilst
T15641 32498-32500 , denotes ,
T15640 32676-32684 VBN denotes required
T15639 32494-32498 RB denotes Thus
T15638 32493-32757 sentence denotes Thus, whilst the lack of lupus nephritis in the congenic mice is consistent with the need for multiple susceptibility genes for the full expression of lupus, further studies will be required to fully elucidate the role of Apcs in the pathogenesis of renal damage.
T15637 32492-32493 . denotes .
T15636 32480-32485 NN denotes organ
T15635 32486-32492 NN denotes damage
T15634 32476-32479 NN denotes end
T15633 32472-32475 CC denotes and
T15632 32461-32462 HYPH denotes -
T15631 32462-32471 NN denotes tolerance
T15630 32457-32461 NN denotes self
T15629 32454-32456 IN denotes in
T15628 32445-32453 VBN denotes involved
T15627 32437-32438 CD denotes 6
T15626 32436-32437 HYPH denotes /
T15625 32431-32436 NN denotes C57BL
T15624 32427-32430 CC denotes and
T15623 32439-32444 NNS denotes genes
T15622 32423-32426 CD denotes 129
T15621 32415-32422 IN denotes between
T15620 32388-32401 JJ denotes counteractive
T15619 32384-32387 CC denotes and
T15618 32372-32383 JJ denotes synergistic
T15617 32364-32371 JJ denotes complex
T15616 32360-32363 CC denotes and
T15615 32351-32359 JJ denotes numerous
T15614 32402-32414 NNS denotes interactions
T15613 32347-32350 DT denotes the
T15612 32344-32346 IN denotes in
T15611 32334-32339 RB denotes still
T15610 32330-32333 MD denotes may
T15609 32321-32329 NNS denotes findings
T15608 32317-32320 PRP$ denotes our
T15607 32313-32316 IN denotes for
T15606 32289-32300 JJ denotes alternative
T15605 32301-32312 NN denotes explanation
T15604 32286-32288 DT denotes an
T15603 32284-32286 , denotes ,
T15602 32283-32284 CD denotes 1
T15601 32272-32282 NN denotes Chromosome
T15600 32269-32271 IN denotes on
T15599 32257-32260 CD denotes 129
T15598 32247-32256 JJ denotes identical
T15597 32243-32246 RB denotes not
T15596 32239-32242 CC denotes but
T15595 32261-32268 NNS denotes regions
T15594 32231-32238 JJ denotes similar
T15593 32216-32217 SYM denotes −
T15592 32215-32216 HYPH denotes /
T15591 32214-32215 SYM denotes −
T15590 32210-32214 NN denotes Apcs
T15589 32218-32222 NNS denotes mice
T15588 32206-32209 DT denotes the
T15587 32202-32205 CC denotes and
T15586 32188-32196 JJ denotes congenic
T15585 32197-32201 NNS denotes mice
T15584 32184-32187 DT denotes the
T15583 32223-32230 VBN denotes carried
T15582 32181-32183 IN denotes as
T15581 32179-32181 , denotes ,
T15580 32340-32343 VB denotes lay
T15579 32172-32179 RB denotes However
T15578 32171-32493 sentence denotes However, as the congenic mice and the Apcs−/− mice carried similar but not identical 129 regions on Chromosome 1, an alternative explanation for our findings may still lay in the numerous and complex synergistic and counteractive interactions between 129 and C57BL/6 genes involved in self-tolerance and end organ damage.
T15577 32170-32171 . denotes .
T15576 32169-32170 -RRB- denotes )
T15575 32165-32169 CD denotes 2004
T15574 32161-32164 FW denotes al.
T15573 32158-32160 FW denotes et
T15572 32150-32157 NNP denotes Russell
T15571 32149-32150 -LRB- denotes (
T15570 32142-32148 NNS denotes humans
T15569 32139-32141 IN denotes in
T15568 32135-32138 NN denotes SLE
T15567 32132-32134 IN denotes to
T15566 32122-32124 VB denotes be
T15565 32125-32131 VBN denotes linked
T15564 32119-32121 TO denotes to
T15563 32105-32109 VBN denotes been
T15562 32101-32104 VBZ denotes has
T15561 32093-32100 NN denotes protein
T15560 32083-32084 HYPH denotes -
T15559 32084-32092 JJ denotes reactive
T15558 32082-32083 NN denotes C
T15557 32079-32081 IN denotes of
T15556 32067-32072 JJ denotes basal
T15555 32073-32078 NN denotes level
T15554 32059-32066 VBN denotes reduced
T15553 32054-32058 IN denotes with
T15552 32043-32053 VBN denotes associated
T15551 32030-32042 NN denotes polymorphism
T15550 32028-32029 DT denotes a
T15549 32026-32028 , denotes ,
T15548 32022-32026 DT denotes this
T15547 32017-32021 IN denotes with
T15546 32110-32118 VBN denotes reported
T15545 32006-32016 JJ denotes Consistent
T15544 32005-32171 sentence denotes Consistent with this, a polymorphism associated with reduced basal level of C-reactive protein has been reported to be linked to SLE in humans (Russell et al. 2004).
T15543 32004-32005 . denotes .
T15542 32003-32004 -RRB- denotes )
T15541 31999-32003 CD denotes 2003
T15540 31995-31998 FW denotes al.
T15539 31992-31994 FW denotes et
T15538 31985-31991 NNP denotes Szalai
T15537 31984-31985 -LRB- denotes (
T15536 31971-31976 JJ denotes renal
T15535 31977-31983 NN denotes cortex
T15534 31967-31970 DT denotes the
T15533 31964-31966 IN denotes in
T15532 31954-31963 NNS denotes complexes
T15531 31947-31953 JJ denotes immune
T15530 31944-31946 IN denotes of
T15529 31933-31943 NN denotes deposition
T15528 31929-31932 DT denotes the
T15527 31918-31928 VBG denotes preventing
T15526 31915-31917 IN denotes by
T15525 31905-31906 HYPH denotes /
T15524 31906-31907 NN denotes W
T15523 31902-31905 NN denotes NZB
T15522 31908-31914 NN denotes strain
T15521 31898-31901 DT denotes the
T15520 31895-31897 IN denotes in
T15519 31885-31894 NN denotes nephritis
T15518 31879-31884 NN denotes lupus
T15517 31876-31878 IN denotes of
T15516 31867-31875 NN denotes severity
T15515 31863-31866 CC denotes and
T15514 31857-31862 NN denotes onset
T15513 31853-31856 DT denotes the
T15512 31847-31852 VB denotes delay
T15511 31844-31846 TO denotes to
T15510 31833-31837 VBN denotes been
T15509 31829-31832 VBZ denotes has
T15508 31827-31829 , denotes ,
T15507 31823-31827 NN denotes Apcs
T15506 31820-31822 IN denotes to
T15505 31812-31819 JJ denotes related
T15504 31804-31811 RB denotes closely
T15503 31789-31790 HYPH denotes -
T15502 31790-31795 NN denotes phase
T15501 31784-31789 JJ denotes acute
T15500 31796-31803 NN denotes protein
T15499 31781-31783 DT denotes an
T15498 31779-31781 , denotes ,
T15497 31762-31763 HYPH denotes -
T15496 31763-31771 JJ denotes reactive
T15495 31761-31762 NN denotes C
T15494 31755-31760 JJ denotes human
T15493 31772-31779 NN denotes protein
T15492 31751-31754 DT denotes the
T15491 31748-31750 IN denotes of
T15490 31737-31747 NN denotes expression
T15489 31733-31736 DT denotes the
T15488 31731-31733 , denotes ,
T15487 31727-31731 DT denotes this
T15486 31724-31726 IN denotes of
T15485 31716-31723 NN denotes support
T15484 31838-31843 VBN denotes shown
T15483 31713-31715 IN denotes In
T15482 31712-32005 sentence denotes In support of this, the expression of the human C-reactive protein, an acute-phase protein closely related to Apcs, has been shown to delay the onset and severity of lupus nephritis in the NZB/W strain by preventing the deposition of immune complexes in the renal cortex (Szalai et al. 2003).
T15481 31711-31712 . denotes .
T15480 31702-31711 NN denotes nephritis
T15479 31696-31701 NN denotes lupus
T15478 31693-31695 IN denotes in
T15477 31677-31687 JJ denotes protective
T15476 31667-31676 JJ denotes important
T15475 31688-31692 NN denotes role
T15474 31664-31666 DT denotes an
T15473 31653-31658 RB denotes still
T15472 31647-31652 MD denotes might
T15471 31642-31646 NN denotes Apcs
T15470 31659-31663 VB denotes play
T15469 31637-31641 IN denotes that
T15468 31623-31627 PRP denotes they
T15467 31621-31623 , denotes ,
T15466 31607-31611 VBN denotes been
T15465 31596-31606 RB denotes previously
T15464 31592-31595 VBD denotes had
T15463 31589-31591 PRP denotes it
T14707 27762-27766 NN denotes 1q22
T14706 27745-27750 JJ denotes human
T14705 27742-27744 IN denotes on
T14704 27735-27741 NN denotes region
T14703 27733-27734 DT denotes a
T14702 27730-27732 IN denotes to
T14701 27718-27729 JJ denotes orthologous
T14700 27713-27714 CD denotes 1
T14699 27702-27712 NN denotes Chromosome
T14698 27696-27701 NN denotes mouse
T14697 27693-27695 IN denotes of
T14696 27686-27692 NN denotes region
T14695 27681-27685 DT denotes this
T14694 27679-27681 , denotes ,
T14693 27715-27717 VBZ denotes is
T14692 27671-27679 RB denotes Moreover
T14691 27670-27835 sentence denotes Moreover, this region of mouse Chromosome 1 is orthologous to a region on human Chromosome 1q22–1q25, which has also been linked with human SLE (Moser et al. 1998).
T14690 27669-27670 . denotes .
T14689 27662-27669 NNS denotes strains
T14688 27655-27656 HYPH denotes -
T14687 27656-27661 JJ denotes prone
T14686 27650-27655 NN denotes lupus
T14685 27647-27649 IN denotes in
T14684 27635-27639 VBN denotes been
T14683 27630-27634 VBP denotes have
T14682 27628-27630 , denotes ,
T14681 27627-27628 -RRB- denotes )
T14680 27623-27627 CD denotes 1998
T14679 27619-27622 FW denotes al.
T14678 27616-27618 FW denotes et
T14677 27608-27615 NNP denotes Hogarth
T14676 27607-27608 -LRB- denotes (
T14675 27602-27606 NN denotes Bxs3
T14674 27598-27601 CC denotes and
T14673 27596-27598 , denotes ,
T14672 27595-27596 -RRB- denotes )
T14671 27591-27595 CD denotes 1997
T14670 27587-27590 FW denotes al.
T14669 27584-27586 FW denotes et
T14668 27579-27583 NNP denotes Vyse
T14667 27577-27578 : denotes ;
T14666 27573-27577 CD denotes 1996
T14665 27569-27572 FW denotes al.
T14664 27566-27568 FW denotes et
T14663 27560-27565 NNP denotes Rozzo
T14662 27558-27559 : denotes ;
T14661 27554-27558 CD denotes 1995
T14660 27550-27553 FW denotes al.
T14659 27547-27549 FW denotes et
T14658 27541-27546 NNP denotes Drake
T14657 27540-27541 -LRB- denotes (
T14656 27535-27539 NN denotes Nba2
T14655 27533-27535 , denotes ,
T14654 27532-27533 -RRB- denotes )
T14653 27528-27532 CD denotes 2001
T14652 27524-27527 FW denotes al.
T14651 27521-27523 FW denotes et
T14650 27515-27520 NNP denotes Morel
T14649 27514-27515 -LRB- denotes (
T14648 27509-27513 NN denotes Sle1
T14647 27498-27508 VBN denotes designated
T14646 27496-27498 , denotes ,
T14645 27484-27491 NN denotes disease
T14644 27492-27496 NNS denotes loci
T14643 27476-27483 JJ denotes several
T14642 27640-27646 VBN denotes mapped
T14641 27470-27475 WRB denotes where
T14640 27468-27470 , denotes ,
T14639 27459-27460 CD denotes 1
T14638 27448-27458 NN denotes Chromosome
T14637 27438-27447 JJ denotes telomeric
T14636 27461-27468 NN denotes segment
T14635 27434-27437 DT denotes the
T14634 27418-27423 NN denotes mouse
T14633 27424-27430 NN denotes genome
T14632 27414-27417 DT denotes the
T14631 27411-27413 IN denotes of
T14630 27395-27402 JJ denotes non-MHC
T14629 27388-27394 VBN denotes mapped
T14628 27375-27387 RB denotes consistently
T14627 27370-27374 RBS denotes most
T14626 27403-27410 NNS denotes regions
T14625 27366-27369 DT denotes the
T14624 27363-27365 IN denotes of
T14623 27359-27362 CD denotes one
T14622 27357-27359 , denotes ,
T14621 27343-27357 NN denotes susceptibility
T14620 27339-27342 NN denotes SLE
T14619 27336-27338 IN denotes of
T14618 27328-27335 NN denotes context
T14617 27324-27327 DT denotes the
T14616 27431-27433 VBZ denotes is
T14615 27321-27323 IN denotes In
T14614 27320-27670 sentence denotes In the context of SLE susceptibility, one of the most consistently mapped non-MHC regions of the mouse genome is the telomeric Chromosome 1 segment, where several disease loci, designated Sle1 (Morel et al. 2001), Nba2 (Drake et al. 1995; Rozzo et al. 1996; Vyse et al. 1997), and Bxs3 (Hogarth et al. 1998), have been mapped in lupus-prone strains.
T14613 27319-27320 . denotes .
T14612 27311-27319 NNS denotes controls
T14611 27291-27302 RB denotes genetically
T14610 27289-27290 CD denotes 1
T14609 27303-27310 VBN denotes matched
T14608 27278-27288 NN denotes Chromosome
T14607 27273-27277 IN denotes with
T14606 27266-27267 SYM denotes −
T14605 27265-27266 HYPH denotes /
T14604 27264-27265 SYM denotes −
T14603 27268-27272 NNS denotes mice
T14602 27259-27263 NN denotes Apcs
T14601 27249-27258 VBG denotes comparing
T14600 27246-27248 IN denotes by
T14599 27229-27236 RB denotes further
T14598 27225-27228 VBD denotes was
T14597 27207-27208 HYPH denotes -
T14596 27208-27216 VBN denotes targeted
T14595 27203-27207 NN denotes gene
T14594 27217-27224 NNS denotes animals
T14593 27195-27202 JJ denotes several
T14592 27192-27194 IN denotes in
T14591 27184-27191 JJ denotes present
T14590 27170-27171 HYPH denotes -
T14589 27171-27175 JJ denotes like
T14588 27165-27170 NN denotes lupus
T14587 27176-27183 NN denotes disease
T14586 27161-27164 DT denotes the
T14585 27158-27160 IN denotes on
T14584 27149-27152 MD denotes may
T14583 27132-27143 VBG denotes interacting
T14582 27144-27148 NNS denotes loci
T14581 27126-27131 DT denotes these
T14580 27153-27157 VB denotes have
T14579 27121-27125 WDT denotes that
T14578 27237-27245 VBN denotes assessed
T14577 27114-27120 NN denotes impact
T14576 27110-27113 DT denotes The
T14575 27109-27320 sentence denotes The impact that these interacting loci may have on the lupus-like disease present in several gene-targeted animals was further assessed by comparing Apcs −/− mice with Chromosome 1 genetically matched controls.
T14574 27108-27109 . denotes .
T14573 27102-27103 CD denotes 6
T14572 27101-27102 HYPH denotes /
T14571 27096-27101 NN denotes C57BL
T14570 27104-27108 NNS denotes mice
T14569 27092-27095 DT denotes the
T14568 27087-27091 IN denotes from
T14567 27074-27086 NN denotes autoimmunity
T14545 26948-26949 -RRB- denotes )
T14544 26947-26948 CD denotes 6
T14543 26946-26947 HYPH denotes /
T14542 26941-26946 NN denotes C57BL
T14541 26939-26940 SYM denotes ×
T14540 26935-26938 CD denotes 129
T14539 26934-26935 -LRB- denotes (
T14538 26968-26974 NN denotes genome
T14537 26930-26933 DT denotes the
T14536 26925-26929 IN denotes from
T14535 26904-26911 JJ denotes genetic
T14534 26896-26903 JJ denotes complex
T14533 26912-26924 NN denotes contribution
T14532 26894-26895 DT denotes a
T14531 26878-26885 NNS denotes results
T14530 26874-26877 PRP$ denotes our
T14529 26865-26873 RB denotes together
T14528 26886-26893 VBP denotes suggest
T14527 26859-26864 VBN denotes Taken
T14526 26858-27109 sentence denotes Taken together our results suggest a complex genetic contribution from the (129 × C57BL/6) hybrid background genome, with both enhancing as well as inhibitory loci from the 129 mouse, in addition to genes promoting autoimmunity from the C57BL/6 mice.
T14525 26857-26858 . denotes .
T14524 26838-26852 NN denotes susceptibility
T14523 26853-26857 NNS denotes loci
T14522 26831-26837 VBN denotes shared
T14521 26828-26830 IN denotes of
T14520 26816-26827 NN denotes possibility
T14519 26812-26815 DT denotes the
T14518 26801-26811 VBG denotes suggesting
T14517 26799-26801 , denotes ,
T14516 26798-26799 -RRB- denotes )
T14515 26794-26798 CD denotes 2002
T14514 26790-26793 FW denotes al.
T14513 26787-26789 FW denotes et
T14512 26783-26786 NNP denotes Xie
T14511 26781-26782 : denotes ;
T14510 26777-26781 CD denotes 1999
T14509 26773-26776 FW denotes al.
T14508 26770-26772 FW denotes et
T14507 26764-26769 NNP denotes Morel
T14506 26762-26763 : denotes ;
T14505 26758-26762 CD denotes 1998
T14504 26754-26757 FW denotes al.
T14503 26751-26753 FW denotes et
T14502 26742-26750 NNP denotes Santiago
T14501 26741-26742 -LRB- denotes (
T14500 26737-26740 NN denotes SLE
T14499 26734-26736 IN denotes of
T14498 26720-26726 JJ denotes murine
T14497 26727-26733 NNS denotes models
T14496 26714-26719 JJ denotes other
T14495 26711-26713 IN denotes in
T14494 26700-26704 JJ denotes same
T14493 26705-26710 NN denotes trait
T14492 26696-26699 DT denotes the
T14491 26693-26695 IN denotes to
T14490 26681-26685 VBN denotes been
T14489 26677-26680 VBZ denotes has
T14488 26667-26676 NN denotes nephritis
T14487 26661-26666 NN denotes lupus
T14486 26658-26660 IN denotes of
T14485 26646-26657 NN denotes development
T14484 26642-26645 DT denotes the
T14483 26637-26641 IN denotes with
T14482 26626-26636 VBN denotes associated
T14481 26624-26625 CD denotes 7
T14480 26613-26623 NN denotes Chromosome
T14479 26610-26612 IN denotes on
T14478 26603-26609 NN denotes region
T14477 26599-26602 DT denotes the
T14476 26597-26599 , denotes ,
T14475 26686-26692 VBN denotes linked
T14474 26586-26597 RB denotes Furthermore
T14473 26585-26858 sentence denotes Furthermore, the region on Chromosome 7 associated with the development of lupus nephritis has been linked to the same trait in other murine models of SLE (Santiago et al. 1998; Morel et al. 1999; Xie et al. 2002), suggesting the possibility of shared susceptibility loci.
T14472 26584-26585 . denotes .
T14471 26583-26584 -RRB- denotes )
T15675 32704-32707 DT denotes the
T15674 32688-32693 RB denotes fully
T15673 32694-32703 VB denotes elucidate
T15672 32685-32687 TO denotes to
T15671 32673-32675 VB denotes be
T15670 32668-32672 MD denotes will
T15669 32660-32667 NNS denotes studies
T15668 32652-32659 JJ denotes further
T15667 32650-32652 , denotes ,
T15666 32645-32650 NN denotes lupus
T15665 32642-32644 IN denotes of
T15664 32626-32630 JJ denotes full
T15663 32631-32641 NN denotes expression
T15662 32622-32625 DT denotes the
T15661 32618-32621 IN denotes for
T15660 32597-32611 NN denotes susceptibility
T15659 32612-32617 NNS denotes genes
T15658 32588-32596 JJ denotes multiple
T15657 32584-32587 IN denotes for
T15656 32579-32583 NN denotes need
T15655 32575-32578 DT denotes the
T15654 32570-32574 IN denotes with
T15653 32559-32569 JJ denotes consistent
T15246 30519-30526 NN denotes FcγRIIB
T15245 30511-30518 VBG denotes lacking
T15244 30506-30510 NNS denotes mice
T15243 30496-30505 VBG denotes including
T15242 30494-30496 , denotes ,
T15241 30481-30482 HYPH denotes -
T15240 30482-30486 JJ denotes like
T15239 30476-30481 NN denotes lupus
T15238 30487-30494 NN denotes illness
T15237 30474-30475 DT denotes a
T15236 30466-30473 VB denotes express
T15235 30463-30465 TO denotes to
T15234 30449-30453 VBN denotes been
T15233 30444-30448 VBP denotes have
T15232 30437-30443 NN denotes region
T15231 30432-30436 DT denotes this
T15230 30429-30431 IN denotes in
T15229 30421-30428 VBN denotes encoded
T15228 30415-30420 NNS denotes genes
T15227 30412-30414 IN denotes of
T15226 30402-30411 NNS denotes mutations
T15225 30393-30401 VBN denotes targeted
T15224 30388-30392 IN denotes with
T15223 30383-30387 NNS denotes mice
T15222 30380-30382 IN denotes of
T15221 30372-30379 NNS denotes strains
T15220 30364-30371 JJ denotes several
T15219 30454-30462 VBN denotes reported
T15218 30359-30363 IN denotes that
T15217 30354-30358 NN denotes note
T15216 30351-30353 IN denotes of
T15215 30345-30347 PRP denotes it
T15214 30343-30345 , denotes ,
T15213 30336-30343 NN denotes context
T15212 30331-30335 DT denotes this
T15211 30348-30350 VBZ denotes is
T15210 30328-30330 IN denotes In
T15209 30327-30679 sentence denotes In this context, it is of note that several strains of mice with targeted mutations of genes encoded in this region have been reported to express a lupus-like illness, including mice lacking FcγRIIB (Bolland and Ravetch 2000), complement receptors (CR1/2) (Prodeus et al. 1998; Wu et al. 2002), and decay-accelerating factor (CD55) (Miwa et al. 2002).
T15208 30326-30327 . denotes .
T15207 30318-30326 NNS denotes auto-Abs
T15206 30315-30317 IN denotes of
T15205 30304-30314 NN denotes production
T15204 30300-30303 DT denotes the
T15203 30292-30299 VB denotes mediate
T15202 30289-30291 TO denotes to
T15201 30278-30288 JJ denotes sufficient
T15200 30272-30274 , denotes ,
T15199 30254-30265 JJ denotes chromosomal
T15198 30266-30272 NN denotes region
T15197 30249-30253 DT denotes that
T15196 30246-30248 IN denotes in
T15195 30238-30245 VBN denotes located
T15194 30225-30232 VBN denotes mutated
T15193 30233-30237 NN denotes gene
T15192 30223-30224 DT denotes a
T15191 30221-30222 CD denotes 6
T15190 30220-30221 HYPH denotes /
T15189 30215-30220 NN denotes C57BL
T15188 30210-30214 IN denotes onto
T15187 30197-30209 VBG denotes backcrossing
T15186 30194-30196 IN denotes by
T15185 30186-30193 VBN denotes created
T15184 30177-30185 RB denotes commonly
T15183 30165-30176 NN denotes combination
T15182 30163-30164 DT denotes a
T15181 30161-30163 , denotes ,
T15180 30153-30154 CD denotes 6
T15179 30152-30153 HYPH denotes /
T15178 30147-30152 NN denotes C57BL
T15177 30155-30161 NN denotes genome
T15176 30143-30146 DT denotes the
T15175 30138-30142 IN denotes onto
T15174 30126-30137 VBN denotes transferred
T15173 30121-30125 WRB denotes when
T15172 30119-30121 , denotes ,
T15171 30118-30119 CD denotes 1
T15170 30107-30117 NN denotes Chromosome
T15169 30100-30106 JJ denotes distal
T15168 30097-30099 IN denotes on
T15167 30084-30087 CD denotes 129
T15166 30088-30096 NN denotes interval
T15165 30080-30083 DT denotes the
T15164 30274-30277 VBD denotes was
T15163 30075-30079 IN denotes that
T15162 30059-30061 PRP denotes we
T15161 30057-30059 , denotes ,
T15160 30049-30057 NN denotes approach
T15159 30044-30048 DT denotes this
T15158 30062-30074 VBD denotes demonstrated
T15157 30038-30043 VBG denotes Using
T15156 30037-30327 sentence denotes Using this approach, we demonstrated that the 129 interval on distal Chromosome 1, when transferred onto the C57BL/6 genome, a combination commonly created by backcrossing onto C57BL/6 a mutated gene located in that chromosomal region, was sufficient to mediate the production of auto-Abs.
T15155 30036-30037 . denotes .
T15154 30023-30030 NN denotes disease
T15153 30031-30036 NN denotes trait
T15152 30018-30022 DT denotes each
T15151 30015-30017 IN denotes to
T15150 30005-30009 NN denotes Apcs
T15149 30010-30014 NN denotes gene
T15148 30001-30004 DT denotes the
T15147 29997-30000 CC denotes and
T15146 29987-29988 CD denotes 1
T15145 29976-29986 NN denotes Chromosome
T15144 29972-29975 CD denotes 129
T15143 29989-29996 NN denotes segment
T15142 29968-29971 DT denotes the
T15141 29965-29967 IN denotes of
T15140 29943-29951 JJ denotes relative
T15139 29952-29964 NN denotes contribution
T15138 29939-29942 DT denotes the
T15137 29927-29938 VB denotes investigate
T15136 29924-29926 TO denotes to
T15135 29910-29914 JJ denotes same
T15134 29915-29923 NN denotes strategy
T15133 29906-29909 DT denotes the
T14972 29047-29051 NN denotes gene
T14971 29038-29041 DT denotes the
T14970 29026-29037 VBG denotes surrounding
T14969 29015-29018 CD denotes 129
T14968 29019-29025 NN denotes region
T14967 29011-29014 DT denotes the
T14966 28983-28984 HYPH denotes -
T14965 28984-28990 NN denotes genome
T14964 28978-28983 JJ denotes whole
T14963 28991-28999 NN denotes analysis
T14962 28974-28977 DT denotes the
T14961 28972-28974 , denotes ,
T14960 29000-29010 VBD denotes identified
T14959 28961-28972 RB denotes Furthermore
T14958 28960-29131 sentence denotes Furthermore, the whole-genome analysis identified the 129 region surrounding the Apcs gene as the main locus contributing to the development of ANA and anti-chromatin Ab.
T14957 28959-28960 . denotes .
T14956 28943-28951 JJ denotes parental
T14955 28952-28959 NNS denotes strains
T14954 28939-28942 DT denotes the
T14953 28934-28938 IN denotes from
T14952 28929-28933 NNS denotes loci
T14951 28925-28928 DT denotes the
T14950 28922-28924 IN denotes of
T14949 28900-28909 JJ denotes nonrandom
T14948 28910-28921 NN denotes inheritance
T14947 28898-28899 DT denotes a
T14946 28886-28890 VB denotes have
T14945 28882-28885 MD denotes may
T14944 28877-28881 DT denotes this
T14943 28891-28897 VBN denotes caused
T14942 28872-28876 IN denotes that
T14941 28868-28871 CC denotes and
T14940 28859-28867 NNS denotes founders
T14939 28856-28858 IN denotes of
T14938 28841-28848 JJ denotes limited
T14937 28849-28855 NN denotes number
T14936 28839-28840 DT denotes a
T14935 28834-28838 IN denotes from
T14934 28819-28823 VBD denotes were
T14933 28804-28812 JJ denotes original
T14932 28813-28818 NN denotes study
T14931 28800-28803 DT denotes the
T14930 28797-28799 IN denotes in
T14929 28788-28796 VBN denotes analysed
T14928 28781-28782 SYM denotes −
T14927 28780-28781 HYPH denotes /
T14926 28779-28780 SYM denotes −
T14925 28774-28778 NN denotes Apcs
T14924 28783-28787 NNS denotes mice
T14923 28770-28773 DT denotes the
T14922 28824-28833 VBN denotes generated
T14921 28765-28769 IN denotes that
T14920 28760-28764 NN denotes fact
T14919 28756-28759 DT denotes the
T14918 28753-28755 IN denotes in
T14917 28745-28748 MD denotes may
T14916 28733-28744 NN denotes discrepancy
T14915 28728-28732 DT denotes this
T14914 28724-28727 IN denotes for
T14913 28749-28752 VB denotes lie
T14912 28703-28711 JJ denotes possible
T14911 28712-28723 NN denotes explanation
T14910 28701-28702 DT denotes A
T14909 28700-28960 sentence denotes A possible explanation for this discrepancy may lie in the fact that the Apcs −/− mice analysed in the original study were generated from a limited number of founders and that this may have caused a nonrandom inheritance of the loci from the parental strains.
T14908 28699-28700 . denotes .
T14907 28693-28694 SYM denotes −
T14906 28692-28693 HYPH denotes /
T14905 28691-28692 SYM denotes −
T14904 28686-28690 NN denotes Apcs
T14903 28685-28686 HYPH denotes .
T14902 28682-28683 -RRB- denotes )
T14901 28681-28682 CD denotes 6
T14900 28680-28681 HYPH denotes /
T14899 28675-28680 NN denotes C57BL
T14898 28673-28674 SYM denotes ×
T14897 28683-28685 NN denotes F2
T14896 28669-28672 CD denotes 129
T14895 28668-28669 -LRB- denotes (
T14894 28695-28699 NNS denotes mice
T14893 28664-28667 DT denotes the
T14892 28661-28663 IN denotes in
T14891 28637-28650 RB denotes significantly
T14890 28632-28636 VBD denotes were
T14889 28622-28624 NN denotes Ab
T14888 28607-28621 JJ denotes anti-chromatin
T14887 28603-28606 CC denotes and
T14886 28599-28602 NN denotes ANA
T14885 28625-28631 NNS denotes levels
T14884 28594-28598 RB denotes only
T14883 28651-28660 VBN denotes increased
T14882 28589-28593 IN denotes that
T14881 28580-28582 PRP denotes we
T14880 28574-28579 NN denotes study
T14879 28569-28573 DT denotes this
T14878 28566-28568 IN denotes in
T14877 28564-28566 , denotes ,
T14876 28583-28588 VBD denotes found
T14875 28557-28564 RB denotes However
T14874 28556-28700 sentence denotes However, in this study we found that only ANA and anti-chromatin Ab levels were significantly increased in the (129 × C57BL/6)F2.Apcs −/− mice.
T14873 28555-28556 . denotes .
T14872 28552-28555 NN denotes SLE
T14871 28549-28551 IN denotes of
T14870 28536-28548 NN denotes pathogenesis
T14869 28532-28535 DT denotes the
T14868 28529-28531 IN denotes to
T14867 28515-28517 , denotes ,
T14866 28506-28515 NN denotes chromatin
T14865 28503-28505 IN denotes of
T14864 28493-28502 NN denotes clearance
T14863 28489-28492 DT denotes the
T14862 28480-28488 VBG denotes altering
T14861 28477-28479 IN denotes by
T14860 28475-28477 , denotes ,
T14859 28471-28475 NN denotes Apcs
T14858 28517-28528 VBZ denotes contributes
T14857 28466-28470 IN denotes that
T14856 28451-28454 VBD denotes was
T14855 28448-28450 PRP denotes it
T14854 28446-28448 , denotes ,
T14853 28434-28446 NNS denotes observations
T14852 28428-28433 DT denotes these
T14851 28425-28427 IN denotes of
T14850 28419-28424 NN denotes basis
T14849 28415-28418 DT denotes the
T14848 28455-28465 VBN denotes postulated
T14847 28412-28414 IN denotes On
T14846 28411-28556 sentence denotes On the basis of these observations, it was postulated that Apcs, by altering the clearance of chromatin, contributes to the pathogenesis of SLE.
T14845 28410-28411 . denotes .
T14844 28409-28410 -RRB- denotes )
T14843 28405-28409 CD denotes 1999
T14842 28401-28404 FW denotes al.
T14841 28398-28400 FW denotes et
T14840 28386-28397 NNP denotes Bickerstaff
T14839 28385-28386 -LRB- denotes (
T14838 28358-28365 NN denotes complex
T14837 28351-28357 JJ denotes immune
T14836 28366-28384 NN denotes glomerulonephritis
T14835 28339-28350 JJ denotes significant
T14834 28331-28338 VB denotes develop
T14833 28327-28330 CC denotes and
T14832 28322-28326 NNS denotes ANAs
T14831 28319-28321 IN denotes of
T14830 28308-28312 JJ denotes wide
T14829 28313-28318 NN denotes range
T14828 28306-28307 DT denotes a
T14827 28284-28297 RB denotes spontaneously
T14826 28277-28278 SYM denotes −
T14825 28276-28277 HYPH denotes /
T14824 28275-28276 SYM denotes −
T14823 28270-28274 NN denotes Apcs
T14822 28269-28270 HYPH denotes .
T14821 28268-28269 -RRB- denotes )
T14820 28267-28268 CD denotes 6
T14819 28266-28267 HYPH denotes /
T14818 28261-28266 NN denotes C57BL
T14817 28259-28260 SYM denotes ×
T14816 28279-28283 NNS denotes mice
T14815 28255-28258 CD denotes 129
T14814 28254-28255 -LRB- denotes (
T14813 28298-28305 VBP denotes produce
T14812 28249-28253 IN denotes that
T14811 28229-28239 RB denotes previously
T14810 28224-28228 VBP denotes have
T14809 28240-28248 VBN denotes reported
T14808 28221-28223 PRP denotes We
T14807 28220-28411 sentence denotes We have previously reported that (129 × C57BL/6).Apcs −/− mice spontaneously produce a wide range of ANAs and develop significant immune complex glomerulonephritis (Bickerstaff et al. 1999).
T14806 28219-28220 . denotes .
T14805 28218-28219 -RRB- denotes )
T14804 28214-28218 CD denotes 2001
T14803 28210-28213 FW denotes al.
T14802 28207-28209 FW denotes et
T14801 28198-28206 NNP denotes Familian
T14800 28196-28197 : denotes ;
T14799 28192-28196 CD denotes 1989
T14798 28188-28191 FW denotes al.
T14797 28185-28187 FW denotes et
T14796 28174-28184 NNP denotes Breathnach
T14795 28172-28173 : denotes ;
T14794 28168-28172 CD denotes 1988
T14793 28164-28167 FW denotes al.
T14792 28161-28163 FW denotes et
T14791 28153-28160 NNP denotes Hintner
T14790 28152-28153 -LRB- denotes (
T14789 28147-28151 FW denotes vivo
T14788 28144-28146 FW denotes in
T14787 28138-28143 NNS denotes cells
T14786 28128-28137 JJ denotes apoptotic
T14785 28124-28127 CC denotes and
T14784 28114-28123 NN denotes chromatin
T14783 28106-28113 VBN denotes exposed
T14470 26579-26583 CD denotes 2000
T14469 26575-26578 FW denotes al.
T14468 26572-26574 FW denotes et
T14467 26564-26571 NNP denotes Haywood
T14466 26562-26563 : denotes ;
T14465 26558-26562 CD denotes 1999
T14464 26554-26557 FW denotes al.
T14463 26551-26553 FW denotes et
T14462 26545-26550 NNP denotes Morel
T14461 26544-26545 -LRB- denotes (
T14460 26538-26543 NN denotes study
T14459 26533-26537 DT denotes this
T14458 26530-26532 IN denotes in
T14457 26519-26529 VBN denotes identified
T14456 26512-26518 NN denotes region
T14455 26508-26511 DT denotes the
T14454 26505-26507 IN denotes to
T14453 26499-26504 JJ denotes close
T14452 26497-26498 CD denotes 3
T14451 26486-26496 NN denotes Chromosome
T14450 26483-26485 IN denotes of
T14449 26475-26482 NN denotes portion
T14448 26473-26474 DT denotes a
T14447 26470-26472 IN denotes to
T14446 26458-26462 VBN denotes been
T14445 26453-26457 VBP denotes have
T14444 26443-26444 CD denotes 6
T14443 26442-26443 HYPH denotes /
T14442 26437-26442 NN denotes C57BL
T14441 26433-26436 CC denotes and
T14440 26430-26432 CD denotes 10
T14439 26429-26430 HYPH denotes /
T14438 26445-26452 NNS denotes strains
T14437 26424-26429 NN denotes C57BL
T14436 26419-26423 IN denotes from
T14435 26411-26418 VBN denotes derived
T14434 26403-26410 NNS denotes alleles
T14433 26392-26393 HYPH denotes -
T14432 26393-26402 VBG denotes modifying
T14431 26385-26392 NN denotes disease
T14430 26383-26385 , denotes ,
T14429 26378-26383 JJ denotes novel
T14428 26373-26374 CD denotes 3
T14427 26362-26372 NN denotes Chromosome
T14426 26359-26361 IN denotes on
T14425 26336-26337 HYPH denotes -
T14424 26337-26351 NN denotes susceptibility
T14423 26333-26336 NN denotes SLE
T14422 26331-26332 CD denotes 6
T14421 26330-26331 HYPH denotes /
T14420 26325-26330 NN denotes C57BL
T14419 26352-26358 NN denotes region
T14418 26321-26324 DT denotes the
T14417 26375-26377 VBZ denotes is
T14416 26312-26320 IN denotes although
T14415 26310-26312 , denotes ,
T14414 26463-26469 VBN denotes mapped
T14413 26297-26310 RB denotes Interestingly
T14412 26296-26585 sentence denotes Interestingly, although the C57BL/6 SLE-susceptibility region on Chromosome 3 is novel, disease-modifying alleles derived from C57BL/10 and C57BL/6 strains have been mapped to a portion of Chromosome 3 close to the region identified in this study (Morel et al. 1999; Haywood et al. 2000).
T14411 26295-26296 . denotes .
T14410 26286-26295 NN denotes tolerance
T14409 26283-26285 IN denotes of
T14408 26278-26282 NN denotes loss
T14407 26274-26277 DT denotes the
T14406 26266-26273 VB denotes mediate
T14405 26263-26265 TO denotes to
T14404 26261-26262 CD denotes 1
T14403 26250-26260 NN denotes Chromosome
T14402 26247-26249 IN denotes on
T14401 26237-26240 CD denotes 129
T14400 26241-26246 NNS denotes genes
T14399 26233-26236 DT denotes the
T14398 26228-26232 IN denotes with
T14397 26215-26218 MD denotes may
T14396 26219-26227 VB denotes interact
T14395 26209-26214 WDT denotes which
T14394 26207-26209 , denotes ,
T14393 26206-26207 CD denotes 3
T14392 26195-26205 NN denotes Chromosome
T14391 26192-26194 IN denotes on
T14390 26182-26183 CD denotes 6
T14389 26181-26182 HYPH denotes /
T14388 26176-26181 NN denotes C57BL
T14387 26184-26191 NN denotes segment
T14386 26174-26175 DT denotes a
T14385 26160-26162 PRP denotes we
T14384 26158-26160 , denotes ,
T14383 26154-26158 DT denotes this
T14382 26151-26153 IN denotes of
T14381 26143-26150 NN denotes support
T14380 26163-26173 VBD denotes identified
T14379 26140-26142 IN denotes In
T14378 26139-26296 sentence denotes In support of this, we identified a C57BL/6 segment on Chromosome 3, which may interact with the 129 genes on Chromosome 1 to mediate the loss of tolerance.
T14377 26138-26139 . denotes .
T14376 26131-26132 CD denotes 6
T14375 26130-26131 HYPH denotes /
T14374 26133-26138 NNS denotes genes
T14373 26125-26130 NN denotes C57BL
T14372 26122-26124 IN denotes of
T14371 26114-26121 NN denotes absence
T14370 26110-26113 DT denotes the
T14369 26107-26109 IN denotes in
T14368 26097-26100 RB denotes not
T14367 26092-26096 VBZ denotes does
T14366 26083-26091 NN denotes response
T14365 26078-26082 DT denotes this
T14364 26076-26078 , denotes ,
T14363 26069-26076 RB denotes however
T14362 26067-26068 : denotes ;
T14361 26059-26067 NNS denotes antigens
T14360 26051-26058 JJ denotes nuclear
T14359 26048-26050 IN denotes to
T14358 26028-26038 JJ denotes autoimmune
T14357 26020-26027 JJ denotes humoral
T14356 26039-26047 NN denotes response
T14355 26018-26019 DT denotes a
T14354 26015-26017 IN denotes of
T14353 26004-26014 NN denotes initiation
T14352 26000-26003 DT denotes the
T14351 25992-25999 VBG denotes causing
T14350 25989-25991 IN denotes of
T14349 25981-25988 JJ denotes capable
T14348 25972-25980 RB denotes probably
T14347 26101-26106 VB denotes occur
T14346 25969-25971 VBZ denotes is
T14345 25962-25968 NN denotes region
T14344 25957-25961 DT denotes This
T14343 25956-26139 sentence denotes This region is probably capable of causing the initiation of a humoral autoimmune response to nuclear antigens; however, this response does not occur in the absence of C57BL/6 genes.
T14342 25955-25956 . denotes .
T14341 25947-25955 NNS denotes auto-Abs
T14340 25944-25946 IN denotes of
T14339 25933-25943 NN denotes expression
T14338 25929-25932 DT denotes the
T14337 25926-25928 IN denotes to
T14336 25919-25925 VBN denotes linked
T14335 25910-25918 RB denotes strongly
T14334 25904-25905 CD denotes 1
T14333 25893-25903 NN denotes Chromosome
T14332 25890-25892 IN denotes of
T14331 25873-25874 HYPH denotes -
T14330 25874-25881 VBN denotes derived
T14212 25288-25299 JJ denotes spontaneous
T14211 25311-25320 NN denotes phenotype
T14210 25286-25287 DT denotes a
T14209 25284-25286 , denotes ,
T14208 25275-25276 CD denotes 6
T14207 25274-25275 HYPH denotes /
T14206 25269-25274 NN denotes C57BL
T14205 25266-25268 CC denotes or
T14204 25262-25265 CD denotes 129
T14203 25257-25261 JJ denotes pure
T14202 25277-25284 NNS denotes strains
T14201 25253-25256 DT denotes the
T14200 25250-25252 IN denotes of
T14199 25243-25249 DT denotes either
T14198 25240-25242 IN denotes in
T14197 25330-25339 VBN denotes described
T14196 25224-25228 VBN denotes been
T14195 25220-25223 RB denotes not
T14194 25216-25219 VBZ denotes has
T14193 25203-25215 NN denotes autoimmunity
T14192 25191-25202 JJ denotes spontaneous
T14191 25229-25239 VBN denotes documented
T14190 25182-25190 IN denotes Although
T14189 25181-25662 sentence denotes Although spontaneous autoimmunity has not been documented in either of the pure 129 or C57BL/6 strains, a spontaneous lupus-like phenotype has been described in (129 × C57BL/6) hybrid strains (Obata et al. 1979; Botto et al. 1998; Bickerstaff et al. 1999; Santiago-Raber et al. 2001), suggesting that the predisposition in these hybrid mice may arise as a result of the interaction between specific combinations of alleles inherited from both the 129 and C57BL/6 parental strains.
T14188 25180-25181 . denotes .
T14187 25176-25180 NNS denotes mice
T14186 25166-25167 HYPH denotes -
T14185 25167-25175 VBN denotes targeted
T14184 25162-25166 NN denotes gene
T14183 25159-25161 IN denotes in
T14182 25140-25147 JJ denotes genetic
T14181 25133-25139 JJ denotes common
T14180 25128-25132 RBS denotes most
T14179 25148-25158 NN denotes background
T14178 25124-25127 DT denotes the
T14177 25122-25124 , denotes ,
T14176 25109-25115 NN denotes hybrid
T14175 25107-25108 -RRB- denotes )
T14174 25106-25107 CD denotes 6
T14173 25105-25106 HYPH denotes /
T14171 25098-25099 SYM denotes ×
T14170 25094-25097 CD denotes 129
T14169 25093-25094 -LRB- denotes (
T14168 25116-25122 NN denotes strain
T14167 25089-25092 DT denotes the
T14166 25086-25088 IN denotes in
T14165 25074-25085 NN denotes inheritance
T14164 25066-25073 NN denotes disease
T14163 25063-25065 IN denotes of
T14162 25049-25056 JJ denotes genetic
T14161 25057-25062 NN denotes basis
T14160 25045-25048 DT denotes the
T14159 25037-25044 VB denotes analyse
T14158 25034-25036 TO denotes to
T14157 25020-25024 JJ denotes same
T14156 25025-25033 NN denotes approach
T14155 25016-25019 DT denotes the
T14154 25002-25006 VBP denotes have
T14153 25007-25015 VBN denotes employed
T14152 24999-25001 PRP denotes We
T14151 24998-25181 sentence denotes We have employed the same approach to analyse the genetic basis of disease inheritance in the (129 × C57BL/6) hybrid strain, the most common genetic background in gene-targeted mice.
T14150 24997-24998 . denotes .
T14149 24978-24990 JJ denotes prerequisite
T14148 24991-24997 NN denotes factor
T14147 24976-24977 DT denotes a
T14146 24970-24975 VBG denotes being
T14145 24957-24963 JJ denotes single
T14144 24964-24969 NN denotes locus
T14143 24954-24956 DT denotes no
T14142 24949-24953 IN denotes with
T14141 24929-24943 NN denotes susceptibility
T14140 24920-24928 JJ denotes discrete
T14139 24944-24948 NNS denotes loci
T14138 24911-24919 JJ denotes multiple
T15132 29898-29905 VBD denotes adopted
T15131 29895-29897 PRP denotes We
T15130 29894-30037 sentence denotes We adopted the same strategy to investigate the relative contribution of the 129 Chromosome 1 segment and the Apcs gene to each disease trait.
T15129 29893-29894 . denotes .
T15128 29890-29893 NN denotes SLE
T15127 29887-29889 IN denotes as
T15126 29882-29886 JJ denotes such
T15125 29865-29875 JJ denotes multigenic
T15124 29876-29881 NN denotes trait
T15123 29863-29864 DT denotes a
T15122 29860-29862 IN denotes to
T15121 29837-29851 NN denotes susceptibility
T15120 29852-29859 NNS denotes alleles
T15119 29826-29836 JJ denotes individual
T15118 29823-29825 IN denotes of
T15117 29810-29822 NN denotes contribution
T15116 29806-29809 DT denotes the
T15115 29798-29805 VB denotes dissect
T15114 29795-29797 TO denotes to
T15113 29785-29789 VBN denotes been
T15112 29772-29784 RB denotes successfully
T15111 29767-29771 VBP denotes have
T15110 29759-29766 NNS denotes strains
T15109 29750-29758 JJ denotes congenic
T15108 29747-29749 IN denotes of
T15107 29738-29746 NN denotes analysis
T15106 29734-29737 CC denotes and
T15105 29790-29794 VBN denotes used
T15104 29723-29733 NN denotes generation
T15103 29719-29722 DT denotes The
T15102 29718-29894 sentence denotes The generation and analysis of congenic strains have successfully been used to dissect the contribution of individual susceptibility alleles to a multigenic trait such as SLE.
T15101 29717-29718 . denotes .
T15100 29707-29710 CD denotes 129
T15099 29711-29717 NN denotes region
T15098 29702-29706 DT denotes this
T15097 29698-29701 IN denotes for
T15096 29689-29697 JJ denotes congenic
T15095 29682-29683 CD denotes 6
T15094 29681-29682 HYPH denotes /
T15093 29676-29681 NN denotes C57BL
T15092 29684-29688 NNS denotes mice
T15091 29672-29675 DT denotes the
T15090 29669-29671 IN denotes of
T15089 29660-29668 NN denotes analysis
T15088 29656-29659 DT denotes the
T15087 29653-29655 IN denotes by
T15086 29640-29643 VBD denotes was
T15085 29635-29639 DT denotes this
T15084 29631-29634 IN denotes for
T15083 29644-29652 VBN denotes provided
T15082 29611-29621 JJ denotes supportive
T15081 29622-29630 NN denotes evidence
T15080 29604-29610 JJ denotes Strong
T15079 29603-29718 sentence denotes Strong supportive evidence for this was provided by the analysis of the C57BL/6 mice congenic for this 129 region.
T15078 29602-29603 . denotes .
T15077 29584-29591 JJ denotes genomic
T15076 29582-29583 CD denotes 6
T15075 29581-29582 HYPH denotes /
T15074 29576-29581 NN denotes C57BL
T15073 29592-29602 NN denotes background
T15072 29572-29575 DT denotes the
T15071 29569-29571 IN denotes in
T15070 29559-29568 VBG denotes operating
T15069 29557-29558 CD denotes 1
T15068 29546-29556 NN denotes Chromosome
T15067 29543-29545 IN denotes of
T15066 29526-29535 JJ denotes telomeric
T15065 29536-29542 NN denotes region
T15064 29522-29525 DT denotes the
T15063 29517-29521 IN denotes from
T15062 29507-29510 CD denotes 129
T15061 29511-29516 NNS denotes genes
T15060 29497-29506 JJ denotes unaltered
T15059 29494-29496 IN denotes of
T15058 29485-29493 NN denotes presence
T15057 29481-29484 DT denotes the
T15056 29478-29480 IN denotes by
T15055 29467-29470 VBD denotes was
T15054 29456-29466 NN denotes deficiency
T15053 29451-29455 NN denotes Apcs
T15052 29446-29450 IN denotes with
T15051 29435-29445 VBN denotes associated
T15050 29425-29434 NN denotes phenotype
T15049 29421-29424 DT denotes the
T15048 29471-29477 VBN denotes caused
T15047 29416-29420 IN denotes that
T15046 29404-29406 , denotes ,
T15045 29396-29404 RB denotes together
T15044 29390-29395 VBN denotes taken
T15043 29388-29390 , denotes ,
T15042 29406-29415 VBD denotes indicated
T15041 29380-29388 NNS denotes findings
T15040 29374-29379 DT denotes These
T15039 29373-29603 sentence denotes These findings, taken together, indicated that the phenotype associated with Apcs deficiency was caused by the presence of unaltered 129 genes from the telomeric region of Chromosome 1 operating in the C57BL/6 genomic background.
T15038 29372-29373 . denotes .
T15037 29360-29363 CD denotes two
T15036 29364-29372 NNS denotes auto-Abs
T15035 29354-29359 DT denotes these
T15034 29351-29353 IN denotes of
T15033 29344-29350 NNS denotes levels
T15032 29340-29343 DT denotes the
T15031 29337-29339 IN denotes in
T15030 29314-29325 JJ denotes significant
T15029 29326-29336 NN denotes difference
T15028 29310-29313 DT denotes any
T15027 29303-29309 VB denotes detect
T15026 29300-29302 TO denotes to
T15025 29290-29292 PRP denotes we
T15024 29288-29290 , denotes ,
T15023 29272-29279 VBN denotes matched
T15022 29260-29271 RB denotes genetically
T15021 29258-29259 CD denotes 1
T15020 29280-29288 NNS denotes controls
T15019 29247-29257 NN denotes Chromosome
T15018 29243-29246 CC denotes and
T15017 29236-29237 SYM denotes −
T15016 29235-29236 HYPH denotes /
T15015 29234-29235 SYM denotes −
T15014 29229-29233 NN denotes Apcs
T15013 29228-29229 HYPH denotes .
T15012 29225-29226 -RRB- denotes )
T15011 29224-29225 CD denotes 6
T15010 29223-29224 HYPH denotes /
T15009 29218-29223 NN denotes C57BL
T15008 29216-29217 SYM denotes ×
T15007 29226-29228 NN denotes F2
T15006 29212-29215 CD denotes 129
T15005 29211-29212 -LRB- denotes (
T15004 29238-29242 NNS denotes mice
T15003 29207-29210 DT denotes the
T15002 29199-29206 IN denotes between
T15001 29178-29187 JJ denotes selective
T15000 29188-29198 NN denotes comparison
T14999 29176-29177 DT denotes a
T14998 29172-29175 RP denotes out
T14997 29161-29163 PRP denotes we
T14996 29164-29171 VBD denotes carried
T14995 29156-29160 WRB denotes when
T14994 29154-29156 , denotes ,
T14993 29150-29154 DT denotes this
T14992 29145-29149 IN denotes with
T14991 29135-29144 NN denotes agreement
T14990 29293-29299 VBD denotes failed
T14989 29132-29134 IN denotes In
T14988 29131-29373 sentence denotes In agreement with this, when we carried out a selective comparison between the (129 × C57BL/6)F2.Apcs −/− mice and Chromosome 1 genetically matched controls, we failed to detect any significant difference in the levels of these two auto-Abs.
T14987 29130-29131 . denotes .
T14986 29128-29130 NN denotes Ab
T14985 29113-29127 JJ denotes anti-chromatin
T14984 29109-29112 CC denotes and
T14983 29105-29108 NN denotes ANA
T14982 29102-29104 IN denotes of
T14981 29090-29101 NN denotes development
T14980 29086-29089 DT denotes the
T14979 29083-29085 IN denotes to
T14978 29070-29082 VBG denotes contributing
T14977 29059-29063 JJ denotes main
T14976 29064-29069 NN denotes locus
T14975 29055-29058 DT denotes the
T14974 29052-29054 IN denotes as
T14973 29042-29046 NN denotes Apcs
T14566 27064-27073 VBG denotes promoting
T14565 27058-27063 NNS denotes genes
T14564 27055-27057 IN denotes to
T14563 27046-27054 NN denotes addition
T14562 27043-27045 IN denotes in
T14561 27041-27043 , denotes ,
T14560 27032-27035 CD denotes 129
T14559 27036-27041 NN denotes mouse
T14558 27028-27031 DT denotes the
T14557 27023-27027 IN denotes from
T14556 27007-27017 JJ denotes inhibitory
T14555 26999-27003 RB denotes well
T14554 27004-27006 IN denotes as
T14553 26996-26998 RB denotes as
T14552 26986-26995 VBG denotes enhancing
T14551 27018-27022 NNS denotes loci
T14550 26981-26985 DT denotes both
T14549 26976-26980 IN denotes with
T14548 26974-26976 , denotes ,
T14547 26957-26967 NN denotes background
T14546 26950-26956 JJ denotes hybrid
T14137 24908-24910 IN denotes of
T14136 24899-24907 NN denotes presence
T14135 24895-24898 DT denotes the
T14134 24890-24894 IN denotes upon
T14133 24862-24870 JJ denotes positive
T14132 24871-24880 NN denotes phenotype
T14131 24860-24861 DT denotes a
T14130 24854-24859 WDT denotes which
T14129 24881-24889 VBD denotes depended
T14128 24851-24853 IN denotes in
T14127 24833-24842 NN denotes liability
T14126 24823-24832 NN denotes threshold
T14125 24843-24850 NN denotes pattern
T14124 24821-24822 DT denotes a
T14123 24794-24803 JJ denotes different
T14122 24804-24811 NNS denotes alleles
T14121 24790-24793 DT denotes the
T14120 24787-24789 IN denotes of
T14119 24775-24786 NN denotes inheritance
T14118 24771-24774 DT denotes the
T14117 24768-24770 IN denotes to
T14116 24759-24767 NN denotes relation
T14115 24756-24758 IN denotes in
T14114 24737-24744 NN denotes disease
T14113 24745-24755 NN denotes expression
T14112 24733-24736 DT denotes the
T14111 24812-24820 VBD denotes followed
T14110 24728-24732 IN denotes that
T14109 24717-24721 VBP denotes have
T14108 24722-24727 VBN denotes shown
T14107 24701-24708 NN denotes mapping
T14106 24709-24716 NNS denotes studies
T14105 24695-24700 DT denotes These
T14104 24694-24998 sentence denotes These mapping studies have shown that the disease expression in relation to the inheritance of the different alleles followed a threshold liability pattern in which a positive phenotype depended upon the presence of multiple discrete susceptibility loci with no single locus being a prerequisite factor.
T14103 24693-24694 . denotes .
T14102 24685-24693 JJ denotes possible
T14101 24675-24679 VBN denotes been
T14100 24671-24674 VBZ denotes has
T14099 24663-24670 NNS denotes crosses
T14098 24650-24662 JJ denotes experimental
T14097 24647-24649 IN denotes in
T14096 24622-24636 NN denotes susceptibility
T14095 24618-24621 NN denotes SLE
T14094 24637-24646 NNS denotes intervals
T14093 24611-24617 JJ denotes murine
T14092 24608-24610 IN denotes of
T14091 24593-24607 NN denotes identification
T14090 24589-24592 DT denotes the
T14089 24587-24589 , denotes ,
T14088 24576-24582 NN denotes marker
T14087 24583-24587 NNS denotes maps
T14086 24561-24575 NN denotes microsatellite
T14085 24558-24560 IN denotes of
T14084 24554-24557 NN denotes use
T14083 24550-24553 DT denotes the
T14082 24680-24684 VBN denotes made
T14081 24542-24549 IN denotes Through
T14080 24541-24694 sentence denotes Through the use of microsatellite marker maps, the identification of murine SLE susceptibility intervals in experimental crosses has been made possible.
T14079 24540-24541 . denotes .
T14078 24526-24530 JJ denotes full
T14077 24531-24540 NN denotes phenotype
T14076 24522-24525 DT denotes the
T14075 24519-24521 IN denotes of
T14074 24508-24518 NN denotes expression
T14073 24504-24507 DT denotes the
T14072 24500-24503 IN denotes for
T14071 24487-24490 VBP denotes are
T14070 24479-24486 NNS denotes alleles
T14069 24464-24478 NN denotes susceptibility
T14068 24461-24463 IN denotes of
T14067 24448-24460 NNS denotes combinations
T14066 24439-24447 JJ denotes specific
T14065 24433-24438 WDT denotes which
T14064 24491-24499 VBN denotes required
T14063 24430-24432 IN denotes in
T14062 24414-24415 HYPH denotes -
T14061 24415-24420 NN denotes trait
T14060 24407-24414 JJ denotes complex
T14059 24421-24429 NN denotes disorder
T14058 24405-24406 DT denotes a
T14057 24402-24404 IN denotes as
T14056 24391-24394 NN denotes SLE
T14055 24389-24391 , denotes ,
T14054 24395-24401 VBZ denotes exists
T14053 24385-24389 RB denotes Thus
T14052 24384-24541 sentence denotes Thus, SLE exists as a complex-trait disorder in which specific combinations of susceptibility alleles are required for the expression of the full phenotype.
T14051 24383-24384 . denotes .
T14050 24382-24383 -RRB- denotes )
T14049 24378-24382 CD denotes 2002
T14048 24374-24377 FW denotes al.
T14047 24371-24373 FW denotes et
T14046 24362-24370 NNP denotes Mitchell
T14045 24360-24361 : denotes ;
T14044 24356-24360 CD denotes 2001
T14043 24352-24355 FW denotes al.
T14042 24349-24351 FW denotes et
T14041 24343-24348 NNP denotes Raber
T14040 24342-24343 HYPH denotes -
T14039 24334-24342 NNP denotes Santiago
T14038 24332-24333 : denotes ;
T14037 24328-24332 CD denotes 2000
T14036 24320-24327 NNP denotes Ravetch
T14035 24316-24319 CC denotes and
T14034 24308-24315 NNP denotes Bolland
T14033 24307-24308 -LRB- denotes (
T14032 24302-24306 NNS denotes mice
T14031 24292-24293 HYPH denotes -
T14030 24293-24301 VBN denotes targeted
T14029 24288-24292 NN denotes gene
T14028 24285-24287 IN denotes in
T14027 24271-24275 VBN denotes been
T14026 24266-24270 RB denotes also
T14025 24261-24265 VBP denotes have
T14024 24248-24260 NN denotes autoimmunity
T14023 24245-24247 IN denotes of
T14022 24234-24244 NN denotes expression
T14021 24230-24233 DT denotes the
T14020 24227-24229 IN denotes on
T14019 24208-24215 JJ denotes genetic
T14018 24216-24226 NN denotes background
T14017 24204-24207 DT denotes the
T14016 24201-24203 IN denotes of
T14015 24193-24200 NNS denotes effects
T14014 24183-24192 JJ denotes important
T14013 24181-24183 , denotes ,
T14012 24276-24284 VBN denotes reported
T14011 24169-24181 RB denotes surprisingly
T14010 24165-24168 RB denotes Not
T14009 24164-24384 sentence denotes Not surprisingly, important effects of the genetic background on the expression of autoimmunity have also been reported in gene-targeted mice (Bolland and Ravetch 2000; Santiago-Raber et al. 2001; Mitchell et al. 2002).
T14008 24163-24164 . denotes .
T14007 24162-24163 -RRB- denotes )
T14006 24158-24162 CD denotes 1988
T14005 24154-24157 FW denotes al.
T14004 24151-24153 FW denotes et
T14003 24146-24150 NNP denotes Izui
T14002 24145-24146 -LRB- denotes (
T14001 24124-24134 JJ denotes autoimmune
T14000 24135-24144 NN denotes phenotype
T13999 24121-24123 DT denotes an
T13998 24118-24120 IN denotes to
T13997 24109-24112 RB denotes not
T13929 23815-23816 HYPH denotes /
T13928 23816-23817 NN denotes J
T13927 23813-23815 NN denotes LG
T13926 23811-23813 , denotes ,
T13925 23808-23811 NN denotes AKR
T13924 23806-23808 , denotes ,
T13923 23805-23806 CD denotes 6
T13922 23804-23805 HYPH denotes /
T13921 23799-23804 NN denotes C57BL
T13920 23796-23798 IN denotes as
T13919 23791-23795 JJ denotes such
T13918 23783-23790 NNS denotes strains
T13917 23777-23782 JJ denotes other
T13916 23774-23776 IN denotes in
T13915 23765-23768 NN denotes lpr
T13914 23769-23773 NN denotes gene
T13913 23761-23764 DT denotes the
T13912 23758-23760 IN denotes of
T13911 23745-23757 NN denotes homozygosity
T13910 23743-23745 , denotes ,
T13909 23735-23743 NN denotes contrast
T13908 23827-23832 VBZ denotes leads
T13907 23732-23734 IN denotes In
T13906 23731-23879 sentence denotes In contrast, homozygosity of the lpr gene in other strains such as C57BL/6, AKR, LG/J, and C3H leads only to auto-Ab production (Izui et al. 1984).
T13905 23730-23731 . denotes .
T13904 23703-23722 JJ denotes lymphoproliferative
T13903 23723-23730 NN denotes disease
T13902 23696-23702 JJ denotes marked
T13901 23693-23695 IN denotes to
T13900 23684-23692 NN denotes addition
T13899 23681-23683 IN denotes in
T13898 23679-23681 , denotes ,
T13897 23661-23679 NN denotes glomerulonephritis
T13896 23654-23660 JJ denotes lethal
T13895 23650-23653 CC denotes and
T13894 23631-23638 NN denotes auto-Ab
T13893 23621-23622 HYPH denotes -
T13892 23622-23630 NN denotes spectrum
T13891 23616-23621 NN denotes broad
T13890 23612-23615 CC denotes and
T13889 23639-23649 NN denotes production
T13888 23606-23611 NN denotes level
T13887 23601-23605 JJ denotes high
T13886 23598-23600 IN denotes of
T13885 23586-23597 NN denotes development
T13884 23582-23585 DT denotes the
T13883 23561-23564 NN denotes lpr
T13882 23565-23569 NN denotes gene
T13881 23557-23560 DT denotes the
T13880 23554-23556 IN denotes of
T13879 23545-23553 NN denotes presence
T13878 23541-23544 DT denotes the
T13877 23539-23541 , denotes ,
T13876 23535-23539 NNS denotes mice
T13875 23531-23532 HYPH denotes /
T13874 23532-23534 NN denotes Mp
T13873 23528-23531 NN denotes MRL
T13872 23570-23581 VBZ denotes accelerates
T13871 23525-23527 IN denotes In
T13870 23524-23731 sentence denotes In MRL/Mp mice, the presence of the lpr gene accelerates the development of high level and broad-spectrum auto-Ab production and lethal glomerulonephritis, in addition to marked lymphoproliferative disease.
T13869 23523-23524 . denotes .
T13868 23502-23503 HYPH denotes -
T13867 23503-23517 NN denotes susceptibility
T13866 23495-23502 NN denotes disease
T13865 23491-23494 NN denotes Yaa
T13864 23487-23490 CC denotes and
T13863 23483-23486 NN denotes lpr
T13862 23518-23523 NNS denotes genes
T13861 23479-23482 DT denotes the
T13860 23476-23478 IN denotes to
T13859 23468-23475 NN denotes respect
T13858 23463-23467 IN denotes with
T13857 23452-23462 RB denotes especially
T13856 23450-23452 , denotes ,
T13855 23445-23450 VBN denotes known
T14329 25870-25873 CD denotes 129
T14328 25882-25889 NN denotes segment
T14327 25868-25869 DT denotes a
T14326 25906-25909 VBD denotes was
T14325 25863-25867 IN denotes that
T14324 25850-25862 VBD denotes demonstrated
T14323 25847-25849 PRP denotes We
T14322 25846-25956 sentence denotes We demonstrated that a 129-derived segment of Chromosome 1 was strongly linked to the expression of auto-Abs.
T14321 25845-25846 . denotes .
T14320 25839-25840 CD denotes 6
T14319 25838-25839 HYPH denotes /
T14318 25833-25838 NN denotes C57BL
T14317 25829-25832 CC denotes and
T14316 25841-25845 NNS denotes mice
T14315 25825-25828 CD denotes 129
T14314 25820-25824 CC denotes both
T14313 25815-25819 IN denotes from
T14312 25803-25806 VBP denotes are
T14311 25807-25814 VBN denotes derived
T14310 25797-25802 DT denotes these
T14309 25793-25796 CC denotes and
T14308 25785-25792 NN denotes disease
T14307 25781-25784 DT denotes the
T14306 25778-25780 IN denotes to
T14305 25765-25777 VBG denotes contributing
T14304 25752-25759 JJ denotes genetic
T14303 25760-25764 NNS denotes loci
T14302 25743-25751 JJ denotes multiple
T14301 25733-25738 EX denotes there
T14300 25739-25742 VBP denotes are
T14299 25728-25732 IN denotes that
T14298 25721-25727 VBD denotes showed
T14297 25718-25720 PRP denotes We
T14296 25717-25846 sentence denotes We showed that there are multiple genetic loci contributing to the disease and these are derived from both 129 and C57BL/6 mice.
T14295 25716-25717 . denotes .
T14294 25712-25716 RB denotes here
T14293 25703-25711 VBN denotes reported
T14292 25689-25696 NN denotes mapping
T14291 25697-25702 NN denotes study
T14290 25685-25688 DT denotes the
T14289 25682-25684 IN denotes by
T14288 25668-25671 VBD denotes was
T14287 25672-25681 VBN denotes confirmed
T14286 25663-25667 DT denotes This
T14285 25662-25717 sentence denotes This was confirmed by the mapping study reported here.
T14284 25661-25662 . denotes .
T14283 25645-25653 JJ denotes parental
T14282 25643-25644 CD denotes 6
T14281 25642-25643 HYPH denotes /
T14280 25637-25642 NN denotes C57BL
T14279 25633-25636 CC denotes and
T14278 25629-25632 CD denotes 129
T14277 25625-25628 DT denotes the
T14276 25654-25661 NNS denotes strains
T14275 25620-25624 CC denotes both
T14274 25615-25619 IN denotes from
T14273 25605-25614 VBN denotes inherited
T14272 25597-25604 NNS denotes alleles
T14271 25594-25596 IN denotes of
T14270 25581-25593 NNS denotes combinations
T14269 25572-25580 JJ denotes specific
T14268 25564-25571 IN denotes between
T14267 25552-25563 NN denotes interaction
T14266 25548-25551 DT denotes the
T14265 25545-25547 IN denotes of
T14264 25538-25544 NN denotes result
T14263 25536-25537 DT denotes a
T14262 25533-25535 IN denotes as
T14261 25523-25526 MD denotes may
T14260 25511-25517 JJ denotes hybrid
T14259 25518-25522 NNS denotes mice
T14258 25505-25510 DT denotes these
T14257 25502-25504 IN denotes in
T14256 25487-25501 NN denotes predisposition
T14255 25483-25486 DT denotes the
T14254 25527-25532 VB denotes arise
T14253 25478-25482 IN denotes that
T14252 25467-25477 VBG denotes suggesting
T14251 25465-25467 , denotes ,
T14250 25464-25465 -RRB- denotes )
T14249 25460-25464 CD denotes 2001
T14248 25456-25459 FW denotes al.
T14247 25453-25455 FW denotes et
T14246 25447-25452 NNP denotes Raber
T14245 25446-25447 HYPH denotes -
T14244 25438-25446 NNP denotes Santiago
T14243 25436-25437 : denotes ;
T14242 25432-25436 CD denotes 1999
T14241 25428-25431 FW denotes al.
T14240 25425-25427 FW denotes et
T14239 25413-25424 NNP denotes Bickerstaff
T14238 25411-25412 : denotes ;
T14237 25407-25411 CD denotes 1998
T14236 25403-25406 FW denotes al.
T14235 25400-25402 FW denotes et
T14234 25394-25399 NNP denotes Botto
T14233 25392-25393 : denotes ;
T14232 25388-25392 CD denotes 1979
T14231 25384-25387 FW denotes al.
T14230 25381-25383 FW denotes et
T14229 25375-25380 NNP denotes Obata
T14228 25374-25375 -LRB- denotes (
T14227 25359-25365 NN denotes hybrid
T14226 25357-25358 -RRB- denotes )
T14225 25356-25357 CD denotes 6
T14224 25355-25356 HYPH denotes /
T14223 25350-25355 NN denotes C57BL
T14222 25348-25349 SYM denotes ×
T14221 25344-25347 CD denotes 129
T14220 25366-25373 NNS denotes strains
T14219 25343-25344 -LRB- denotes (
T14218 25340-25342 IN denotes in
T14217 25325-25329 VBN denotes been
T14216 25321-25324 VBZ denotes has
T14215 25305-25306 HYPH denotes -
T14214 25306-25310 JJ denotes like
T14213 25300-25305 NN denotes lupus
T13854 23440-23444 RB denotes well
T13853 23418-23428 JJ denotes autoimmune
T13852 23429-23436 NN denotes disease
T13851 23406-23417 JJ denotes spontaneous
T13850 23403-23405 IN denotes of
T13849 23391-23402 NN denotes development
T13848 23387-23390 DT denotes the
T13847 23384-23386 IN denotes on
T13846 23378-23383 NNS denotes genes
T13845 23367-23377 NN denotes background
T13844 23364-23366 IN denotes of
T13843 23437-23439 VBZ denotes is
T13842 23354-23363 NN denotes influence
T13841 23350-23353 DT denotes The
T13840 23349-23524 sentence denotes The influence of background genes on the development of spontaneous autoimmune disease is well known, especially with respect to the lpr and Yaa disease-susceptibility genes.
T13839 23348-23349 . denotes .
T13838 23335-23343 VBN denotes targeted
T13837 23344-23348 NN denotes gene
T13836 23331-23334 DT denotes the
T13835 23328-23330 IN denotes as
T13834 23316-23320 JJ denotes same
T13833 23321-23327 NN denotes region
T13832 23312-23315 DT denotes the
T13831 23309-23311 IN denotes in
T13830 23299-23308 VBN denotes expressed
T13829 23289-23292 CD denotes 129
T13828 23282-23288 JJ denotes normal
T13827 23293-23298 NNS denotes genes
T13826 23278-23281 DT denotes the
T13825 23275-23277 IN denotes to
T13824 23272-23274 CC denotes or
T13823 23260-23266 NN denotes mutant
T13822 23250-23251 HYPH denotes -
T13821 23251-23259 VBN denotes targeted
T13820 23246-23250 NN denotes gene
T13819 23267-23271 NN denotes gene
T13818 23242-23245 DT denotes the
T13817 23239-23241 IN denotes to
T13816 23235-23238 IN denotes due
T13815 23206-23218 JJ denotes anti-nuclear
T13814 23219-23231 NN denotes autoimmunity
T13813 23202-23205 DT denotes the
T13812 23232-23234 VBZ denotes is
T13811 23194-23201 IN denotes whether
T13810 23191-23193 IN denotes to
T13809 23188-23190 IN denotes as
T13808 23179-23187 NN denotes question
T13807 23177-23178 DT denotes a
T13806 23174-23176 VB denotes be
T13805 23171-23173 TO denotes to
T13804 23161-23166 EX denotes there
T13803 23159-23161 , denotes ,
T13802 23155-23159 DT denotes each
T13801 23167-23170 VBZ denotes has
T13800 23151-23154 IN denotes For
T13799 23150-23349 sentence denotes For each, there has to be a question as to whether the anti-nuclear autoimmunity is due to the gene-targeted mutant gene or to the normal 129 genes expressed in the same region as the targeted gene.
T13798 23149-23150 . denotes .
T13797 23148-23149 -RRB- denotes )
T13796 23144-23148 CD denotes 2002
T13795 23140-23143 FW denotes al.
T13794 23137-23139 FW denotes et
T13793 23134-23136 NNP denotes Wu
T13792 23132-23133 : denotes ;
T13791 23128-23132 CD denotes 2002
T13790 23124-23127 FW denotes al.
T13789 23121-23123 FW denotes et
T13788 23116-23120 NNP denotes Miwa
T13787 23114-23115 : denotes ;
T13786 23110-23114 CD denotes 2000
T13785 23102-23109 NNP denotes Ravetch
T13784 23098-23101 CC denotes and
T13783 23090-23097 NNP denotes Bolland
T13782 23089-23090 -LRB- denotes (
T13781 23070-23077 JJ denotes genetic
T13780 23065-23069 JJ denotes pure
T13779 23078-23088 NN denotes background
T13778 23063-23064 DT denotes a
T13777 23058-23062 IN denotes onto
T13776 23046-23057 VBD denotes backcrossed
T13775 23041-23045 RB denotes then
T13774 23037-23040 CC denotes and
T13773 23026-23030 NN denotes stem
T13772 23016-23025 JJ denotes embryonic
T13771 23031-23036 NNS denotes cells
T13770 23012-23015 CD denotes 129
T13769 23009-23011 IN denotes in
T13768 22999-23008 VBG denotes targeting
T13767 22998-22999 HYPH denotes -
T13766 22994-22998 NN denotes gene
T13765 22991-22993 IN denotes by
T13764 22979-22990 VBN denotes inactivated
T13763 22974-22978 WRB denotes when
T13762 22970-22973 NN denotes SLE
T13761 22967-22969 IN denotes of
T13760 22955-22966 NN denotes development
T13759 22951-22954 DT denotes the
T13758 22948-22950 IN denotes in
T13757 22932-22936 VBN denotes been
T13756 22927-22931 VBP denotes have
T13755 22937-22947 VBN denotes implicated
T13754 22922-22926 WDT denotes that
T13753 22913-22914 CD denotes 1
T13752 22902-22912 NN denotes Chromosome
T13751 22897-22901 JJ denotes same
T13750 22915-22921 NN denotes region
T13749 22893-22896 DT denotes the
T13748 22890-22892 IN denotes in
T13747 22882-22889 VBN denotes located
T13746 22876-22881 NNS denotes genes
T13745 22870-22875 JJ denotes other
T13744 22867-22869 IN denotes to
T13743 22859-22866 VBZ denotes applies
T13742 22840-22844 JJ denotes same
T13741 22845-22858 NN denotes consideration
T13740 22836-22839 DT denotes The
T13739 22835-23150 sentence denotes The same consideration applies to other genes located in the same Chromosome 1 region that have been implicated in the development of SLE when inactivated by gene-targeting in 129 embryonic stem cells and then backcrossed onto a pure genetic background (Bolland and Ravetch 2000; Miwa et al. 2002; Wu et al. 2002).
T13738 22834-22835 . denotes .
T13737 22833-22834 -RRB- denotes )
T13736 22829-22833 CD denotes 1999
T13735 22825-22828 FW denotes al.
T13734 22822-22824 FW denotes et
T13733 22810-22821 NNP denotes Bickerstaff
T13732 22809-22810 -LRB- denotes (
T13731 22804-22808 NNS denotes data
T13730 22800-22803 PRP$ denotes our
T13729 22797-22799 IN denotes of
T13728 22773-22781 JJ denotes original
T13727 22769-22772 JJ denotes own
T13726 22782-22796 NN denotes interpretation
T13725 22765-22768 PRP$ denotes our
T13724 22762-22764 IN denotes to
T13723 22753-22761 JJ denotes contrary
T13722 22751-22753 , denotes ,
T13721 22739-22751 NN denotes autoimmunity
T13720 22726-22738 JJ denotes anti-nuclear
T13719 22723-22725 IN denotes of
T13718 22713-22722 NN denotes induction
T13717 22709-22712 DT denotes the
T13716 22706-22708 IN denotes in
T13715 22694-22699 JJ denotes prime
T13714 22700-22705 NN denotes mover
T13996 24104-24108 VBZ denotes does
T13995 24095-24098 NN denotes Yaa
T13994 24099-24103 NN denotes gene
T13993 24091-24094 DT denotes the
T13992 24089-24091 , denotes ,
T13991 24077-24078 CD denotes 6
T13990 24076-24077 HYPH denotes /
T13989 24071-24076 NN denotes C57BL
T13988 24079-24089 NN denotes background
T13987 24067-24070 DT denotes the
T13986 24064-24066 IN denotes in
T13985 24062-24064 , denotes ,
T13984 24113-24117 VB denotes lead
T13983 24055-24062 RB denotes However
T13982 24054-24164 sentence denotes However, in the C57BL/6 background, the Yaa gene does not lead to an autoimmune phenotype (Izui et al. 1988).
T13981 24053-24054 . denotes .
T13980 24052-24053 -RRB- denotes )
T13979 24048-24052 CD denotes 1989
T13978 24044-24047 FW denotes al.
T13977 24041-24043 FW denotes et
T13976 24034-24040 NNP denotes Merino
T13975 24032-24033 : denotes ;
T13974 24028-24032 CD denotes 1988
T13973 24024-24027 FW denotes al.
T13972 24021-24023 FW denotes et
T13971 24016-24020 NNP denotes Izui
T13970 24015-24016 -LRB- denotes (
T13969 23996-24014 NN denotes glomerulonephritis
T13968 23992-23995 CC denotes and
T13967 23983-23991 NNS denotes auto-Abs
T13966 23980-23982 IN denotes of
T13965 23962-23967 JJ denotes rapid
T13964 23968-23979 NN denotes development
T13963 23958-23961 DT denotes the
T13962 23939-23940 HYPH denotes /
T13961 23940-23942 NN denotes Mp
T13960 23936-23939 NN denotes MRL
T13959 23932-23935 CC denotes and
T13958 23943-23948 NNS denotes males
T13957 23927-23931 NN denotes BXSB
T13956 23924-23926 IN denotes in
T13955 23915-23918 NN denotes Yaa
T13954 23907-23908 HYPH denotes -
T13953 23908-23914 VBN denotes linked
T13952 23896-23897 HYPH denotes -
T13951 23897-23907 NN denotes chromosome
T13950 23895-23896 NN denotes Y
T13949 23919-23923 NN denotes gene
T13948 23891-23894 DT denotes the
T13947 23889-23891 , denotes ,
T13946 23949-23957 VBZ denotes enhances
T13945 23880-23889 RB denotes Similarly
T13944 23879-24054 sentence denotes Similarly, the Y-chromosome-linked Yaa gene in BXSB and MRL/Mp males enhances the rapid development of auto-Abs and glomerulonephritis (Izui et al. 1988; Merino et al. 1989).
T13943 23878-23879 . denotes .
T13942 23877-23878 -RRB- denotes )
T13941 23873-23877 CD denotes 1984
T13940 23869-23872 FW denotes al.
T13939 23866-23868 FW denotes et
T13938 23861-23865 NNP denotes Izui
T13937 23860-23861 -LRB- denotes (
T13936 23849-23859 NN denotes production
T13935 23841-23848 NN denotes auto-Ab
T13934 23838-23840 IN denotes to
T13933 23833-23837 RB denotes only
T13932 23823-23826 NN denotes C3H
T13931 23819-23822 CC denotes and
T13930 23817-23819 , denotes ,
T13713 22690-22693 DT denotes the
T13712 22686-22689 RB denotes not
T13711 22683-22685 VBZ denotes is
T13710 22679-22682 CC denotes but
T13709 22677-22679 , denotes ,
T13708 22659-22677 NN denotes glomerulonephritis
T13707 22656-22658 IN denotes of
T13706 22647-22655 NN denotes severity
T13705 22643-22646 DT denotes the
T13704 22621-22631 NN denotes deficiency
T13703 22609-22610 NN denotes P
T13702 22601-22608 NN denotes amyloid
T13701 22611-22620 NN denotes component
T13700 22595-22600 NN denotes serum
T13699 22632-22642 VBZ denotes influences
T13698 22590-22594 IN denotes that
T13697 22574-22576 PRP denotes we
T13696 22572-22574 , denotes ,
T13695 22563-22567 NN denotes Apcs
T13694 22568-22572 NN denotes gene
T13693 22559-22562 DT denotes the
T13692 22551-22558 VBG denotes lacking
T13691 22537-22545 JJ denotes congenic
T13690 22546-22550 NNS denotes mice
T13689 22529-22536 VBN denotes matched
T13688 22524-22528 IN denotes with
T13687 22508-22516 JJ denotes congenic
T13686 22506-22507 CD denotes 1
T13685 22495-22505 NN denotes Chromosome
T13684 22517-22523 NN denotes strain
T13683 22490-22494 DT denotes this
T13682 22480-22489 VBG denotes comparing
T13681 22577-22589 VBD denotes demonstrated
T13680 22477-22479 IN denotes By
T13679 22476-22835 sentence denotes By comparing this Chromosome 1 congenic strain with matched congenic mice lacking the Apcs gene, we demonstrated that serum amyloid P component deficiency influences the severity of glomerulonephritis, but is not the prime mover in the induction of anti-nuclear autoimmunity, contrary to our own original interpretation of our data (Bickerstaff et al. 1999).
T13678 22475-22476 . denotes .
T13677 22450-22462 JJ denotes anti-nuclear
T13676 22463-22475 NN denotes autoimmunity
T13675 22441-22449 JJ denotes striking
T13674 22417-22425 JJ denotes congenic
T13673 22411-22412 HYPH denotes -
T13672 22412-22416 NN denotes type
T13671 22407-22411 JJ denotes wild
T13670 22426-22430 NN denotes line
T13669 22402-22406 DT denotes this
T13668 22431-22440 VBD denotes expressed
T13667 22397-22401 IN denotes that
T13666 22390-22396 VBD denotes showed
T13665 22386-22389 CC denotes and
T13664 22373-22374 CD denotes 6
T13663 22372-22373 HYPH denotes /
T13662 22367-22372 NN denotes C57BL
T13661 22375-22385 NN denotes background
T13660 22365-22366 DT denotes a
T13659 22362-22364 IN denotes on
T13658 22360-22361 CD denotes 1
T13657 22349-22359 NN denotes Chromosome
T13656 22345-22348 CD denotes 129
T13655 22342-22344 IN denotes of
T13654 22334-22341 NN denotes portion
T13653 22332-22333 DT denotes a
T13652 22324-22331 VBG denotes bearing
T13651 22311-22316 NN denotes mouse
T13650 22302-22310 JJ denotes congenic
T13649 22317-22323 NN denotes strain
T13648 22300-22301 DT denotes a
T13647 22285-22289 RB denotes also
T13646 22290-22299 VBD denotes developed
T13645 22282-22284 PRP denotes We
T13644 22281-22476 sentence denotes We also developed a congenic mouse strain bearing a portion of 129 Chromosome 1 on a C57BL/6 background and showed that this wild-type congenic line expressed striking anti-nuclear autoimmunity.
T13643 22280-22281 . denotes .
T13642 22261-22262 HYPH denotes -
T13641 22262-22270 VBN denotes targeted
T13640 22257-22261 NN denotes gene
T13639 22271-22280 NNS denotes mutations
T13638 22253-22256 DT denotes any
T13637 22250-22252 IN denotes of
T13636 22242-22249 NN denotes absence
T13635 22238-22241 DT denotes the
T13634 22235-22237 IN denotes in
T13633 22233-22235 , denotes ,
T13632 22226-22233 NNS denotes animals
T13631 22220-22225 DT denotes these
T13630 22217-22219 IN denotes in
T13629 22196-22206 JJ denotes autoimmune
T13628 22187-22195 JJ denotes powerful
T13627 22207-22216 NN denotes phenotype
T13626 22185-22186 DT denotes a
T13625 22182-22184 IN denotes of
T13624 22171-22181 NN denotes expression
T13623 22167-22170 DT denotes the
T13622 22157-22160 MD denotes can
T13621 22161-22166 VB denotes cause
T13620 22152-22156 WDT denotes that
T13619 22145-22146 CD denotes 6
T13618 22144-22145 HYPH denotes /
T13617 22139-22144 NN denotes C57BL
T13616 22135-22138 CC denotes and
T13615 22147-22151 NNS denotes mice
T13614 22131-22134 CD denotes 129
T13613 22123-22130 IN denotes between
T13612 22118-22122 NNS denotes loci
T13611 22106-22117 VBG denotes interacting
T13610 22094-22105 VBP denotes demonstrate
T13609 22086-22093 NNS denotes results
T13608 22082-22085 PRP$ denotes Our
T13607 22081-22281 sentence denotes Our results demonstrate interacting loci between 129 and C57BL/6 mice that can cause the expression of a powerful autoimmune phenotype in these animals, in the absence of any gene-targeted mutations.
T13606 22080-22081 . denotes .
T13605 22071-22080 NN denotes targeting
T13604 22066-22070 NN denotes gene
T13603 22062-22065 IN denotes for
T13602 22057-22061 VBN denotes used
T13601 22050-22056 RB denotes widely
T13600 22048-22050 , denotes ,
T13599 22035-22040 NN denotes mouse
T13598 22033-22034 CD denotes 6
T13597 22032-22033 HYPH denotes /
T13596 22027-22032 NN denotes C57BL
T13595 22023-22026 CC denotes and
T13594 22019-22022 CD denotes 129
T13593 22041-22048 NNS denotes strains
T13592 22015-22018 DT denotes the
T13591 22012-22014 IN denotes in
T13590 22007-22011 DT denotes this
T13589 21994-21997 VBZ denotes has
T13588 21998-22006 VBN denotes examined
T13587 21989-21993 WDT denotes that
T13586 21972-21982 JJ denotes systematic
T13585 21966-21971 JJ denotes first
T13584 21983-21988 NN denotes study
T13583 21962-21965 DT denotes the
T13582 21952-21961 NN denotes knowledge
T13581 21948-21951 PRP$ denotes our
T13580 21945-21947 IN denotes to
T13579 21942-21944 VBZ denotes is
T13578 21937-21941 WP denotes what
T13577 21927-21929 PRP denotes we
T13576 21930-21936 VBP denotes report
T13575 21922-21926 RB denotes Here
T13574 21921-22081 sentence denotes Here we report what is to our knowledge the first systematic study that has examined this in the 129 and C57BL/6 mouse strains, widely used for gene targeting.
T13573 21920-21921 . denotes .
T13572 21916-21920 NNS denotes mice
T13571 21906-21907 HYPH denotes -
T13570 21907-21915 VBN denotes targeted
T13569 21902-21906 NN denotes gene
T13568 21899-21901 IN denotes in
T13567 21886-21898 NN denotes autoimmunity
T13566 21883-21885 IN denotes of
T13565 21872-21882 NN denotes expression
T13564 21868-21871 DT denotes the
T13563 21854-21857 MD denotes may
T13562 21848-21853 NNS denotes genes
T13561 21837-21847 NN denotes background
T13560 21858-21867 VB denotes influence
T13559 21832-21836 IN denotes that
T13558 21823-21831 NN denotes evidence
T13557 21810-21822 VBG denotes accumulating
T13556 21807-21809 VBZ denotes is
T13555 21801-21806 EX denotes There
T9300 20791-20792 . denotes .
T9299 20779-20784 JJ denotes renal
T9298 20785-20791 NN denotes damage
T9297 20772-20778 JJ denotes severe
T9296 20769-20771 IN denotes of
T9295 20757-20768 NN denotes development
T9294 20753-20756 DT denotes the
T9293 20742-20745 MD denotes can
T9292 20740-20742 , denotes ,
T9291 20718-20732 NN denotes susceptibility
T9290 20716-20717 CD denotes 6
T9289 20715-20716 HYPH denotes /
T9288 20710-20715 NN denotes C57BL
T9287 20733-20740 NNS denotes alleles
T9286 20704-20709 JJ denotes other
T9285 20699-20703 IN denotes with
T9284 20690-20698 VBN denotes combined
T9283 20685-20689 WRB denotes when
T9282 20683-20685 , denotes ,
T9281 20679-20683 NN denotes Apcs
T9280 20676-20678 IN denotes of
T9279 20671-20675 NN denotes lack
T9278 20667-20670 DT denotes the
T9277 20746-20752 VB denotes induce
T9276 20662-20666 IN denotes that
T9275 20651-20661 VBG denotes suggesting
T9274 20649-20651 , denotes ,
T9273 20648-20649 -RRB- denotes )
T9272 20647-20648 CD denotes 9
T9271 20640-20646 NN denotes Figure
T9270 20639-20640 -LRB- denotes (
T9269 20624-20631 NN denotes control
T9268 20632-20638 NNS denotes groups
T9267 20619-20623 CC denotes both
T9266 20616-20618 IN denotes to
T9265 20607-20615 VBN denotes compared
T9264 20605-20606 SYM denotes −
T9263 20604-20605 HYPH denotes /
T9262 20603-20604 SYM denotes −
T9261 20598-20602 NN denotes Apcs
T9260 20597-20598 HYPH denotes .
T9259 20596-20597 CD denotes 6
T9258 20595-20596 HYPH denotes /
T9257 20590-20595 NN denotes C57BL
T9256 20586-20589 DT denotes the
T9255 20583-20585 IN denotes in
T9254 20554-20563 VBN denotes increased
T9253 20564-20582 NN denotes glomerulonephritis
T9252 20545-20553 RB denotes markedly
T9251 20542-20544 IN denotes of
T9250 20533-20541 NN denotes evidence
T9249 20518-20525 NNS denotes kidneys
T9248 20514-20517 DT denotes the
T9247 20511-20513 IN denotes of
T9246 20487-20499 JJ denotes histological
T9245 20500-20510 NN denotes assessment
T9244 20483-20486 DT denotes the
T9243 20481-20483 , denotes ,
T9242 20465-20476 JJ denotes serological
T9241 20477-20481 NNS denotes data
T9240 20461-20464 DT denotes the
T9239 20458-20460 IN denotes to
T9238 20449-20457 NN denotes contrast
T9237 20446-20448 IN denotes in
T9236 20444-20446 , denotes ,
T9235 20526-20532 VBD denotes showed
T9234 20437-20444 RB denotes However
T9233 20436-20792 sentence denotes However, in contrast to the serological data, the histological assessment of the kidneys showed evidence of markedly increased glomerulonephritis in the C57BL/6.Apcs −/− compared to both control groups (Figure 9), suggesting that the lack of Apcs, when combined with other C57BL/6 susceptibility alleles, can induce the development of severe renal damage.
T9232 20435-20436 . denotes .
T9231 20423-20435 NNS denotes autoantigens
T9230 20415-20422 JJ denotes nuclear
T9229 20412-20414 IN denotes to
T9228 20402-20411 NN denotes tolerance
T9227 20399-20401 IN denotes of
T9226 20394-20398 NN denotes loss
T9225 20390-20393 DT denotes the
T9224 20382-20389 VB denotes mediate
T9223 20379-20381 TO denotes to
T9222 20368-20378 JJ denotes sufficient
T9221 20355-20356 CD denotes 6
T9220 20354-20355 HYPH denotes /
T9219 20357-20362 NNS denotes genes
T9218 20349-20354 NN denotes C57BL
T9217 20345-20348 CC denotes and
T9216 20343-20344 CD denotes 1
T9215 20332-20342 NN denotes Chromosome
T9214 20329-20331 IN denotes on
T9213 20324-20328 NNS denotes loci
T9212 20320-20323 CD denotes 129
T9211 20312-20319 IN denotes between
T9210 20299-20311 NNS denotes interactions
T9209 20289-20298 JJ denotes epistatic
T9208 20363-20367 VBD denotes were
T9207 20284-20288 IN denotes that
T9206 20263-20270 RB denotes clearly
T9205 20271-20283 VBD denotes demonstrated
T9204 20255-20262 NNS denotes results
T9203 20249-20254 DT denotes These
T9202 20248-20436 sentence denotes These results clearly demonstrated that epistatic interactions between 129 loci on Chromosome 1 and C57BL/6 genes were sufficient to mediate the loss of tolerance to nuclear autoantigens.
T9201 20247-20248 . denotes .
T9200 20238-20242 NN denotes Apcs
T9199 20243-20247 NN denotes gene
T9198 20234-20237 DT denotes the
T9197 20231-20233 IN denotes of
T9196 20217-20221 JJ denotes null
T9195 20222-20230 NN denotes mutation
T9194 20215-20216 DT denotes a
T9193 20204-20214 VBG denotes containing
T9192 20190-20198 JJ denotes congenic
T9191 20182-20189 VBN denotes matched
T9190 20199-20203 NNS denotes mice
T9189 20178-20181 DT denotes the
T9188 20175-20177 IN denotes in
T9187 20166-20174 VBN denotes detected
T9186 20160-20165 DT denotes those
T9185 20155-20159 IN denotes from
T9184 20145-20154 JJ denotes different
T9183 20141-20144 RB denotes not
T9182 20136-20140 VBD denotes were
T9181 20129-20135 NNS denotes titres
T9180 20123-20128 DT denotes these
T9179 20119-20122 CC denotes and
T9178 20117-20119 , denotes ,
T9177 20109-20117 NNS denotes auto-Abs
T9176 20106-20108 IN denotes of
T9175 20099-20105 NNS denotes levels
T9174 20094-20098 JJ denotes high
T9173 20079-20083 RB denotes also
T9172 20069-20070 -RRB- denotes )
T9171 20066-20069 CD denotes 223
T9170 20065-20066 SYM denotes –
T9169 20057-20065 NN denotes D1Mit105
T9168 20056-20057 -LRB- denotes (
T9167 20053-20056 CD denotes 129
T9166 20052-20053 HYPH denotes .
T9165 20051-20052 CD denotes 6
T9164 20050-20051 HYPH denotes /
T9163 20045-20050 NN denotes C57BL
T9162 20071-20078 NNS denotes animals
T9161 20041-20044 DT denotes the
T9160 20039-20041 , denotes ,
T9159 20084-20093 VBD denotes expressed
T9158 20032-20039 RB denotes However
T9157 20031-20248 sentence denotes However, the C57BL/6.129(D1Mit105–223) animals also expressed high levels of auto-Abs, and these titres were not different from those detected in the matched congenic mice containing a null mutation of the Apcs gene.
T9156 20030-20031 . denotes .
T9155 20020-20021 CD denotes 6
T9154 20019-20020 HYPH denotes /
T9153 20014-20019 NN denotes C57BL
T9152 20008-20009 HYPH denotes -
T9151 20009-20013 NN denotes type
T9150 20004-20008 JJ denotes wild
T9149 20022-20030 NNS denotes controls
T9148 20000-20003 DT denotes the
T9147 19997-19999 IN denotes to
T9146 19988-19996 VBN denotes compared
T9145 19986-19987 SYM denotes −
T9144 19985-19986 HYPH denotes /
T9143 19984-19985 SYM denotes −
T9142 19979-19983 NN denotes Apcs
T9141 19978-19979 HYPH denotes .
T9140 19977-19978 CD denotes 6
T9139 19976-19977 HYPH denotes /
T9138 19971-19976 NN denotes C57BL
T9137 19967-19970 DT denotes the
T9136 19964-19966 IN denotes in
T9135 19945-19953 RB denotes markedly
T9134 19940-19944 VBD denotes were
T9133 19931-19939 NNS denotes auto-Abs
T9132 19928-19930 IN denotes of
T9131 19921-19927 NNS denotes levels
T9130 19917-19920 DT denotes the
T9129 19915-19917 , denotes ,
T9128 19914-19915 -RRB- denotes )
T9127 19910-19914 CD denotes 1999
T9126 19906-19909 FW denotes al.
T9125 19903-19905 FW denotes et
T9124 19891-19902 NNP denotes Bickerstaff
T9123 19890-19891 -LRB- denotes (
T9122 19954-19963 VBN denotes increased
T9090 19724-19727 NN denotes age
T9089 19721-19723 IN denotes of
T9088 19719-19720 NN denotes y
T9087 19717-19718 CD denotes 1
T9086 19746-19756 VBN denotes sacrificed
T9085 19714-19716 IN denotes At
T9084 19713-19814 sentence denotes At 1 y of age, all animals were sacrificed, the auto-Abs assessed, and the renal histology examined.
T9083 19712-19713 . denotes .
T9082 19711-19712 -RRB- denotes )
T9081 19704-19705 SYM denotes –
T9080 19705-19708 CD denotes 105
T9079 19700-19704 CD denotes 87.9
T9078 19709-19711 NN denotes cM
T9077 19699-19700 -LRB- denotes (
T9076 19692-19693 SYM denotes −
T9075 19691-19692 HYPH denotes /
T9074 19690-19691 SYM denotes −
T9073 19685-19689 NN denotes Apcs
T9072 19684-19685 HYPH denotes .
T9071 19683-19684 CD denotes 6
T9070 19682-19683 HYPH denotes /
T9069 19677-19682 NN denotes C57BL
T9068 19694-19698 NNS denotes mice
T9067 19673-19676 DT denotes the
T9066 19670-19672 IN denotes in
T9065 19662-19669 JJ denotes present
T9064 19658-19661 CD denotes one
T9063 19654-19657 DT denotes the
T9062 19651-19653 IN denotes to
T9061 19649-19650 -RRB- denotes )
T9060 19642-19643 SYM denotes –
T9059 19643-19646 CD denotes 106
T9058 19640-19642 CD denotes 80
T9057 19647-19649 NN denotes cM
T9056 19639-19640 -LRB- denotes (
T9055 19628-19631 CD denotes 129
T9054 19620-19627 JJ denotes similar
T9053 19632-19638 NN denotes region
T9052 19618-19619 DT denotes a
T9051 19596-19604 JJ denotes congenic
T9050 19605-19609 NN denotes line
T9049 19592-19595 DT denotes the
T9048 19590-19592 , denotes ,
T9047 19610-19617 VBD denotes carried
T9046 19586-19590 RB denotes Thus
T9045 19585-19713 sentence denotes Thus, the congenic line carried a similar 129 region (80–106 cM) to the one present in the C57BL/6.Apcs −/− mice (87.9–105 cM).
T9044 19584-19585 . denotes .
T9043 19583-19584 -RRB- denotes )
T9042 19576-19583 NN denotes D1Mit17
T9041 19575-19576 -LRB- denotes (
T9040 19572-19574 NN denotes cM
T9039 19568-19571 CD denotes 105
T9038 19565-19567 IN denotes to
T9037 19563-19564 -RRB- denotes )
T9036 19556-19563 NN denotes D1Mit15
T9035 19555-19556 -LRB- denotes (
T9034 19552-19554 NN denotes cM
T9033 19547-19551 CD denotes 87.9
T9032 19542-19546 IN denotes from
T9031 19531-19541 VBN denotes positioned
T9030 19529-19531 , denotes ,
T9029 19527-19529 NN denotes cM
T9028 19524-19526 CD denotes 17
T9027 19510-19523 RB denotes approximately
T9026 19507-19509 IN denotes of
T9025 19499-19506 NN denotes stretch
T9024 19497-19498 DT denotes a
T9023 19494-19496 IN denotes as
T9022 19483-19486 VBD denotes was
T9021 19472-19476 NN denotes Apcs
T9020 19477-19482 NN denotes locus
T9019 19468-19471 DT denotes the
T9018 19461-19467 IN denotes around
T9017 19450-19453 CD denotes 129
T9016 19454-19460 NN denotes genome
T9015 19446-19449 DT denotes the
T9014 19444-19446 , denotes ,
T9013 19438-19439 SYM denotes −
T9012 19437-19438 HYPH denotes /
T9011 19436-19437 SYM denotes −
T9010 19431-19435 NN denotes Apcs
T9009 19430-19431 HYPH denotes .
T9008 19429-19430 CD denotes 6
T9007 19428-19429 HYPH denotes /
T9006 19423-19428 NN denotes C57BL
T9005 19440-19444 NNS denotes mice
T9004 19419-19422 DT denotes the
T9003 19487-19493 VBN denotes mapped
T9002 19416-19418 IN denotes In
T9001 19415-19585 sentence denotes In the C57BL/6.Apcs −/− mice, the 129 genome around the Apcs locus was mapped as a stretch of approximately 17 cM, positioned from 87.9 cM (D1Mit15) to 105 cM (D1Mit17).
T9000 19414-19415 . denotes .
T8999 19409-19414 NN denotes lupus
T8998 19406-19408 IN denotes of
T8997 19397-19405 NN denotes presence
T8996 19393-19396 DT denotes the
T8995 19389-19392 IN denotes for
T8994 19374-19378 VBD denotes were
T8993 19372-19374 , denotes ,
T8992 19362-19363 CD denotes 6
T8991 19361-19362 HYPH denotes /
T8990 19364-19372 NNS denotes controls
T8989 19356-19361 NN denotes C57BL
T8988 19352-19355 CC denotes and
T8987 19350-19351 -RRB- denotes )
T8986 19349-19350 SYM denotes −
T8985 19348-19349 HYPH denotes /
T8984 19347-19348 SYM denotes −
T8983 19342-19346 NN denotes Apcs
T8982 19341-19342 HYPH denotes .
T8981 19340-19341 CD denotes 6
T8980 19339-19340 HYPH denotes /
T8979 19334-19339 NN denotes C57BL
T8978 19333-19334 -LRB- denotes (
T8977 19321-19332 NNS denotes generations
T8976 19317-19320 CD denotes ten
T8975 19313-19316 IN denotes for
T8974 19311-19312 CD denotes 6
T8973 19310-19311 HYPH denotes /
T8972 19305-19310 NN denotes C57BL
T8971 19300-19304 IN denotes onto
T8970 19288-19299 VBN denotes backcrossed
T8969 19281-19282 SYM denotes −
T8968 19280-19281 HYPH denotes /
T8967 19279-19280 SYM denotes −
T8966 19274-19278 NN denotes Apcs
T8965 19283-19287 NNS denotes mice
T8964 19265-19266 HYPH denotes -
T8963 19266-19273 VBN denotes matched
T8962 19262-19265 NN denotes sex
T8961 19257-19261 IN denotes with
T8960 19248-19256 RB denotes together
T8959 19246-19248 , denotes ,
T8958 19245-19246 -RRB- denotes )
T8957 19244-19245 -RRB- denotes ]
T8956 19241-19244 CD denotes 223
T8955 19240-19241 SYM denotes –
T8954 19232-19240 NN denotes D1Mit105
T8953 19231-19232 -LRB- denotes [
T8952 19228-19231 CD denotes 129
T8951 19227-19228 HYPH denotes .
T8950 19226-19227 CD denotes 6
T8949 19225-19226 HYPH denotes /
T8948 19220-19225 NN denotes C57BL
T8947 19219-19220 -LRB- denotes (
T8946 19379-19388 VBN denotes monitored
T8945 19205-19213 JJ denotes congenic
T8944 19203-19204 CD denotes 1
T8943 19192-19202 NN denotes Chromosome
T8942 19214-19218 NNS denotes mice
T8941 19185-19191 JJ denotes Female
T8940 19184-19415 sentence denotes Female Chromosome 1 congenic mice (C57BL/6.129[D1Mit105–223]), together with sex-matched Apcs −/− mice backcrossed onto C57BL/6 for ten generations (C57BL/6.Apcs −/−) and C57BL/6 controls, were monitored for the presence of lupus.
T8939 19183-19184 . denotes .
T8938 19176-19178 NN denotes F2
T8937 19175-19176 -RRB- denotes )
T8936 19172-19173 HYPH denotes /
T8935 19173-19175 NN denotes Sv
T8934 19169-19172 NN denotes 129
T8932 19165-19166 CD denotes 6
T8931 19164-19165 HYPH denotes /
T8930 19159-19164 NN denotes C57BL
T8929 19158-19159 -LRB- denotes (
T8928 19179-19183 NNS denotes mice
T8927 19154-19157 DT denotes the
T8926 19151-19153 IN denotes in
T8925 19135-19142 NN denotes linkage
T8924 19143-19150 NNS denotes studies
T8923 19131-19134 DT denotes the
T8922 19128-19130 IN denotes by
T8921 19117-19127 VBN denotes identified
T8920 19104-19107 CD denotes 129
T8919 19094-19103 JJ denotes important
T8918 19089-19093 RBS denotes most
T8917 19108-19116 NN denotes interval
T8916 19085-19088 DT denotes the
T8915 19073-19084 VBZ denotes encompasses
T8914 19067-19072 WDT denotes which
T8913 19065-19067 , denotes ,
T8912 19064-19065 -RRB- denotes )
T8911 19057-19058 SYM denotes –
T8910 19058-19061 CD denotes 106
T8909 19055-19057 CD denotes 80
T8908 19062-19064 NNS denotes cM
T8907 19054-19055 -LRB- denotes (
T8906 19045-19053 NN denotes D1Mit223
T8905 19042-19044 IN denotes to
T8904 19033-19041 NN denotes D1Mit105
T8903 19026-19032 NN denotes marker
T8902 19011-19025 NN denotes microsatellite
T8901 19006-19010 IN denotes from
T8900 18983-18991 JJ denotes congenic
T8899 18992-18996 NNS denotes mice
T8898 18979-18982 DT denotes the
T8897 18976-18978 IN denotes in
T8896 18965-18966 CD denotes 1
T8895 18954-18964 NN denotes Chromosome
T8894 18945-18946 HYPH denotes -
T8893 18946-18953 VBN denotes derived
T8892 18942-18945 CD denotes 129
T8891 18967-18975 NN denotes interval
T8890 18938-18941 DT denotes the
T8889 18936-18938 , denotes ,
T8888 18924-18936 NN denotes backcrossing
T8887 18920-18923 DT denotes the
T8886 18917-18919 IN denotes of
T8885 18913-18916 NN denotes end
T8884 18909-18912 DT denotes the
T8883 18997-19005 VBN denotes extended
T8882 18906-18908 IN denotes At
T8881 18905-19184 sentence denotes At the end of the backcrossing, the 129-derived Chromosome 1 interval in the congenic mice extended from microsatellite marker D1Mit105 to D1Mit223 (80–106 cM), which encompasses the most important 129 interval identified by the linkage studies in the (C57BL/6 × 129/Sv)F2 mice.
T8880 18904-18905 . denotes .
T8879 18889-18896 JJ denotes genomic
T8878 18885-18888 CD denotes 129
T8877 18897-18904 NNS denotes regions
T8876 18874-18884 JJ denotes unselected
T8875 18871-18873 IN denotes of
T8867 18811-18815 IN denotes than
T8866 18816-18821 CD denotes three
T8865 18806-18810 JJR denotes more
T8864 18801-18805 IN denotes with
T8863 18788-18791 VBD denotes was
T8862 18792-18800 VBN denotes screened
T8861 18765-18776 VBN denotes backcrossed
T8860 18777-18787 NN denotes generation
T8859 18760-18764 DT denotes Each
T8858 18759-18905 sentence denotes Each backcrossed generation was screened with more than three markers per chromosome to facilitate the removal of unselected 129 genomic regions.
T8857 18758-18759 . denotes .
T8856 18736-18750 NN denotes microsatellite
T8855 18751-18758 NNS denotes markers
T8854 18728-18735 JJ denotes several
T8853 18723-18727 IN denotes with
T8852 18708-18711 VBD denotes was
T8851 18697-18698 CD denotes 1
T8850 18686-18696 NN denotes Chromosome
T8849 18699-18707 NN denotes interval
T8848 18682-18685 DT denotes the
T8847 18679-18681 IN denotes of
T8846 18671-18678 NN denotes absence
T8845 18668-18670 CC denotes or
T8844 18659-18667 NN denotes presence
T8843 18655-18658 DT denotes the
T8842 18644-18654 NN denotes generation
T8841 18639-18643 DT denotes each
T8840 18712-18722 VBN denotes determined
T8839 18636-18638 IN denotes at
T8838 18632-18635 CC denotes and
T8837 18630-18632 , denotes ,
T8836 18629-18630 CD denotes 6
T8835 18628-18629 HYPH denotes /
T8834 18623-18628 NN denotes C57BL
T8833 18618-18622 IN denotes onto
T8832 18612-18617 NNS denotes times
T8831 18606-18611 CD denotes seven
T8830 18590-18593 VBD denotes was
T8829 18594-18605 VBN denotes backcrossed
T8828 18577-18580 CD denotes 129
T8827 18581-18589 NN denotes interval
T8826 18573-18576 DT denotes The
T8825 18572-18759 sentence denotes The 129 interval was backcrossed seven times onto C57BL/6, and at each generation the presence or absence of the Chromosome 1 interval was determined with several microsatellite markers.
T8824 18571-18572 . denotes .
T8823 18553-18560 JJ denotes genetic
T8822 18542-18552 JJ denotes individual
T8821 18561-18571 NNS denotes components
T8820 18538-18541 PRP$ denotes its
T8819 18533-18537 IN denotes into
T8818 18519-18525 NN denotes hybrid
T8817 18516-18518 NN denotes F2
T8816 18515-18516 -RRB- denotes )
T8815 18512-18513 HYPH denotes /
T8814 18513-18515 NN denotes Sv
T8813 18509-18512 NN denotes 129
T8812 18507-18508 SYM denotes ×
T8811 18505-18506 CD denotes 6
T8810 18504-18505 HYPH denotes /
T8809 18499-18504 NN denotes C57BL
T8808 18498-18499 -LRB- denotes (
T8807 18526-18532 NN denotes strain
T8806 18494-18497 DT denotes the
T8805 18491-18493 IN denotes of
T8804 18473-18480 NN denotes disease
T8803 18463-18472 JJ denotes polygenic
T8802 18455-18462 JJ denotes complex
T8801 18481-18490 NN denotes phenotype
T8800 18451-18454 DT denotes the
T8799 18443-18450 VB denotes dissect
T8798 18440-18442 TO denotes to
T8797 18434-18439 NN denotes order
T8796 18431-18433 IN denotes in
T8795 18429-18431 , denotes ,
T8794 18417-18422 NN denotes mouse
T8793 18413-18416 CD denotes 129
T9121 19870-19880 RB denotes previously
T9120 19881-19889 VBN denotes reported
T9119 19867-19869 IN denotes As
T9118 19866-20031 sentence denotes As previously reported (Bickerstaff et al. 1999), the levels of auto-Abs were markedly increased in the C57BL/6.Apcs −/− compared to the wild-type C57BL/6 controls.
T9117 19865-19866 . denotes .
T9116 19864-19865 CD denotes 8
T9115 19857-19863 NN denotes Figure
T9114 19854-19856 IN denotes in
T9113 19844-19847 VBP denotes are
T9112 19835-19843 NN denotes analysis
T9111 19830-19834 DT denotes this
T9110 19827-19829 IN denotes of
T9109 19848-19853 VBN denotes shown
T9108 19819-19826 NNS denotes results
T9107 19815-19818 DT denotes The
T9106 19814-19866 sentence denotes The results of this analysis are shown in Figure 8.
T9105 19813-19814 . denotes .
T9104 19805-19813 VBN denotes examined
T9103 19789-19794 JJ denotes renal
T9102 19795-19804 NN denotes histology
T9101 19785-19788 DT denotes the
T9100 19781-19784 CC denotes and
T9099 19779-19781 , denotes ,
T9098 19771-19779 VBN denotes assessed
T9097 19762-19770 NNS denotes auto-Abs
T9096 19758-19761 DT denotes the
T9095 19756-19758 , denotes ,
T9094 19741-19745 VBD denotes were
T9093 19733-19740 NNS denotes animals
T9092 19729-19732 DT denotes all
T9091 19727-19729 , denotes ,
T8792 18423-18429 NN denotes strain
T8791 18409-18412 DT denotes the
T8790 18404-18408 IN denotes from
T8789 18402-18403 CD denotes 1
T8788 18391-18401 NN denotes Chromosome
T8787 18388-18390 IN denotes of
T8786 18371-18380 JJ denotes telomeric
T8785 18381-18387 NN denotes region
T8784 18367-18370 DT denotes the
T8783 18358-18366 VBG denotes carrying
T8782 18344-18352 JJ denotes congenic
T8781 18342-18343 CD denotes 6
T8780 18341-18342 HYPH denotes /
T8779 18336-18341 NN denotes C57BL
T8778 18353-18357 NN denotes line
T8777 18334-18335 DT denotes a
T8776 18324-18333 VBD denotes generated
T8775 18321-18323 PRP denotes We
T8774 18320-18572 sentence denotes We generated a C57BL/6 congenic line carrying the telomeric region of Chromosome 1 from the 129 mouse strain, in order to dissect the complex polygenic disease phenotype of the (C57BL/6 × 129/Sv)F2 hybrid strain into its individual genetic components.
T8773 18301-18311 JJ denotes Phenotypic
T8772 18312-18320 NN denotes Analysis
T8771 18297-18300 PRP$ denotes Its
T8770 18293-18296 CC denotes and
T8769 18279-18287 JJ denotes Congenic
T8768 18277-18278 CD denotes 1
T8767 18266-18276 NN denotes Chromosome
T8766 18262-18265 CD denotes 129
T8765 18261-18262 HYPH denotes .
T8764 18260-18261 CD denotes 6
T8763 18259-18260 HYPH denotes /
T8762 18254-18259 NN denotes C57BL
T8761 18288-18292 NN denotes Line
T8760 18252-18253 DT denotes a
T8759 18249-18251 IN denotes of
T8758 18238-18248 NN denotes Production
T8874 18863-18870 NN denotes removal
T8873 18859-18862 DT denotes the
T8872 18848-18858 VB denotes facilitate
T8871 18845-18847 TO denotes to
T8870 18834-18844 NN denotes chromosome
T8869 18830-18833 IN denotes per
T8868 18822-18829 NNS denotes markers
T7638 17863-17865 , denotes ,
T7637 17862-17863 -RRB- denotes )
T7636 17854-17855 SYM denotes =
T7635 17856-17862 CD denotes 0.0013
T7634 17852-17853 NN denotes p
T7633 17850-17852 , denotes ,
T7632 17846-17850 CD denotes 2.86
T7631 17842-17845 NN denotes LOD
T7630 17841-17842 -LRB- denotes (
T7629 17834-17840 NN denotes origin
T7628 17830-17833 CD denotes 129
T7627 17827-17829 IN denotes of
T7626 17825-17826 -RRB- denotes )
T7625 17818-17822 CD denotes 26.5
T7624 17823-17825 NN denotes cM
T7623 17817-17818 -LRB- denotes (
T7622 17808-17816 NN denotes D7Mit145
T7621 17804-17807 CC denotes and
T7620 17802-17803 -RRB- denotes )
T7619 17797-17799 CD denotes 15
T7618 17800-17802 NN denotes cM
T7617 17796-17797 -LRB- denotes (
T7616 17787-17795 NN denotes D7Mit246
T7615 17779-17786 IN denotes between
T7614 17769-17771 NN denotes cM
T7613 17766-17768 CD denotes 10
T7612 17772-17778 NN denotes region
T7611 17764-17765 DT denotes a
T7610 17757-17763 IN denotes across
T7609 17755-17756 CD denotes 7
T7608 17744-17754 NN denotes Chromosome
T7607 17741-17743 IN denotes on
T7606 17730-17731 HYPH denotes -
T7605 17731-17735 NN denotes type
T7604 17726-17730 JJ denotes wild
T7603 17736-17740 NNS denotes mice
T7602 17722-17725 DT denotes the
T7601 17719-17721 IN denotes in
T7600 17715-17718 CD denotes one
T7599 17713-17715 : denotes :
T7598 17695-17713 NN denotes glomerulonephritis
T7597 17692-17694 IN denotes to
T7596 17673-17682 JJ denotes potential
T7595 17669-17672 CD denotes two
T7594 17683-17691 NNS denotes linkages
T7593 17664-17668 RB denotes only
T7592 17640-17643 NN denotes QTL
T7591 17644-17652 NN denotes analysis
T7590 17636-17639 DT denotes the
T7589 17634-17636 , denotes ,
T7588 17615-17626 JJ denotes serological
T7587 17627-17634 NNS denotes markers
T7586 17607-17614 NN denotes disease
T7585 17602-17606 IN denotes with
T7584 17582-17588 JJ denotes strong
T7583 17589-17601 NNS denotes associations
T7582 17576-17581 DT denotes these
T7581 17573-17575 IN denotes to
T7580 17564-17572 NN denotes contrast
T7579 17653-17663 VBD denotes identified
T7578 17561-17563 IN denotes In
T7577 17024-18060 sentence denotes Figure 7 Interval Mapping Scans Showing QTL on Chromosome 3 with ANA, Anti-Chromatin, and Anti-ssDNA Abs See Table 3 for additional details. Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines indicate the threshold over which linkage was considered suggestive, the dashed line indicate the threshold over which linkage was considered significant, and dotted/dashed lines indicate highly significant linkage, as defined in Materials and Methods. In contrast to these strong associations with disease serological markers, the QTL analysis identified only two potential linkages to glomerulonephritis: one in the wild-type mice on Chromosome 7 across a 10 cM region between D7Mit246 (15 cM) and D7Mit145 (26.5 cM) of 129 origin (LOD 2.86, p = 0.0013), and one on Chromosome 17 between D17Mit100 (11.7 cM) and D17Mit216 (29.4 cM) from the C57BL/6 strain (LOD 1.3, p = 0.049 and LOD 1.67, p = 0.021 in the wild-type and Apcs −/− mice, respectively).
T7576 17023-17024 . denotes .
T7575 17020-17023 CD denotes 6.4
T7574 17016-17019 NN denotes LOD
T7573 17013-17015 IN denotes to
T7572 17009-17012 CD denotes 5.4
T7571 17007-17008 -RRB- denotes )
T7570 17004-17007 NN denotes LOD
T7569 17003-17004 -LRB- denotes (
T7568 16998-17002 NNS denotes odds
T7567 16995-16997 IN denotes of
T7566 16985-16994 NN denotes logarithm
T7565 16980-16984 IN denotes from
T7564 16966-16969 NN denotes ANA
T7563 16962-16965 IN denotes for
T7562 16960-16961 CD denotes 3
T7561 16949-16959 NN denotes Chromosome
T7560 16946-16948 IN denotes on
T7559 16938-16939 CD denotes 6
T7558 16937-16938 HYPH denotes /
T7557 16932-16937 NN denotes C57BL
T7556 16940-16945 NN denotes locus
T7555 16928-16931 DT denotes the
T7554 16925-16927 IN denotes of
T7553 16917-16924 NN denotes linkage
T7552 16913-16916 DT denotes the
T7551 16909-16912 IN denotes for
T7550 16889-16900 JJ denotes statistical
T7549 16901-16908 NN denotes support
T7548 16885-16888 DT denotes the
T7547 16970-16979 VBD denotes increased
T7546 16880-16884 IN denotes that
T7545 16864-16872 NN denotes analysis
T7544 16859-16863 DT denotes this
T7543 16856-16858 IN denotes of
T7542 16873-16879 VBD denotes showed
T7541 16848-16855 NNS denotes results
T7540 16844-16847 DT denotes The
T7539 16843-17024 sentence denotes The results of this analysis showed that the statistical support for the linkage of the C57BL/6 locus on Chromosome 3 for ANA increased from logarithm of odds (LOD) 5.4 to LOD 6.4.
T7538 16842-16843 . denotes .
T7537 16841-16842 -RRB- denotes )
T7536 16837-16841 CD denotes 1994
T7535 16832-16836 NNP denotes Zeng
T7534 16831-16832 -LRB- denotes (
T7533 16810-16820 RB denotes previously
T7532 16821-16830 VBN denotes described
T7531 16807-16809 IN denotes as
T7530 16805-16807 , denotes ,
T7529 16804-16805 CD denotes 1
T7528 16793-16803 NN denotes Chromosome
T7527 16786-16792 JJ denotes distal
T7526 16783-16785 IN denotes on
T7525 16772-16775 CD denotes 129
T7524 16765-16771 JJ denotes strong
T7523 16760-16764 RB denotes very
T7522 16776-16782 NN denotes effect
T7521 16756-16759 DT denotes the
T7520 16752-16755 IN denotes for
T7519 16740-16751 VBG denotes controlling
T7518 16733-16739 IN denotes whilst
T7517 16731-16733 , denotes ,
T7516 16724-16726 NN denotes F2
T7515 16723-16724 -RRB- denotes )
T7514 16722-16723 CD denotes 6
T7513 16721-16722 HYPH denotes /
T7512 16716-16721 NN denotes C57BL
T7511 16714-16715 SYM denotes ×
T7510 16710-16713 CD denotes 129
T7509 16727-16731 NNS denotes mice
T7508 16709-16710 -LRB- denotes (
T7507 16706-16708 IN denotes in
T7506 16689-16696 NN denotes linkage
T7505 16697-16705 NN denotes analysis
T7504 16685-16688 DT denotes the
T7503 16675-16684 VBG denotes repeating
T7502 16672-16674 IN denotes by
T7501 16659-16660 CD denotes 6
T7500 16658-16659 HYPH denotes /
T7499 16653-16658 NN denotes C57BL
T7498 16661-16671 NN denotes background
T7497 16649-16652 DT denotes the
T7496 16644-16648 IN denotes from
T7495 16638-16643 NNS denotes genes
T7494 16635-16637 IN denotes of
T7493 16627-16634 NNS denotes effects
T7492 16623-16626 DT denotes the
T7491 16615-16622 RB denotes further
T7490 16602-16614 VBD denotes investigated
T7489 16599-16601 PRP denotes We
T7488 16598-16843 sentence denotes We investigated further the effects of genes from the C57BL/6 background by repeating the linkage analysis in (129 × C57BL/6)F2 mice, whilst controlling for the very strong 129 effect on distal Chromosome 1, as previously described (Zeng 1994).
T7487 16597-16598 . denotes .
T7486 16585-16597 NN denotes autoimmunity
T7485 16582-16584 IN denotes of
T7484 16571-16581 NN denotes expression
T7483 16567-16570 DT denotes the
T7482 16563-16566 IN denotes for
T7481 16555-16562 NNS denotes alleles
T7480 16546-16547 HYPH denotes -
T7479 16545-16546 CD denotes 6
T7478 16544-16545 HYPH denotes /
T7477 16539-16544 NN denotes C57BL
T7476 16535-16538 CC denotes and
T7475 16533-16534 HYPH denotes -
T7474 16547-16554 VBN denotes derived
T7473 16530-16533 CD denotes 129
T7472 16522-16529 IN denotes between
T7471 16509-16521 NNS denotes interactions
T7470 16499-16508 JJ denotes essential
T7469 16489-16494 EX denotes there
T7468 16495-16498 VBP denotes are
T7467 16484-16488 IN denotes that
T7466 16461-16469 JJ denotes parental
T7465 16454-16460 JJ denotes inbred
T7464 16470-16477 NNS denotes strains
T7463 16450-16453 DT denotes the
T7462 16447-16449 IN denotes of
T7461 16440-16446 DT denotes either
T7460 16437-16439 IN denotes in
T7459 16429-16436 NN denotes absence
T7458 16425-16428 PRP$ denotes its
T7457 16421-16424 CC denotes and
T7456 16402-16409 JJ denotes genetic
T7455 16395-16401 JJ denotes hybrid
T7454 16393-16394 -RRB- denotes )
T7453 16392-16393 CD denotes 6
T7452 16391-16392 HYPH denotes /
T7451 16386-16391 NN denotes C57BL
T7450 16384-16385 SYM denotes ×
T7449 16380-16383 CD denotes 129
T7448 16379-16380 -LRB- denotes (
T7447 16410-16420 NN denotes background
T7446 16375-16378 DT denotes the
T7445 16372-16374 IN denotes in
T7444 16362-16371 NN denotes phenotype
T7443 16351-16361 JJ denotes autoimmune
T7442 16348-16350 IN denotes of
T7441 16478-16483 VBP denotes imply
T7440 16333-16337 JJ denotes high
T7439 16338-16347 NN denotes frequency
T7438 16329-16332 DT denotes The
T7437 16328-16598 sentence denotes The high frequency of autoimmune phenotype in the (129 × C57BL/6) hybrid genetic background and its absence in either of the inbred parental strains imply that there are essential interactions between 129- and C57BL/6-derived alleles for the expression of autoimmunity.
T7436 16327-16328 . denotes .
T7435 16326-16327 -RRB- denotes )
T7434 16325-16326 CD denotes 7
T7433 16318-16324 NN denotes Figure
T7432 16316-16317 : denotes ;
T7431 16315-16316 CD denotes 3
T7430 16309-16314 NN denotes Table
T7429 16305-16308 VB denotes see
T7428 16304-16305 -LRB- denotes (
T7427 16278-16292 JJ denotes anti-chromatin
T7426 16274-16277 CC denotes and
T7425 16293-16303 NN denotes production
T7424 16263-16273 JJ denotes anti-ssDNA
T7423 16260-16262 IN denotes to
T7402 16128-16135 NN denotes D3Mit13
T7401 16124-16127 CC denotes and
T7400 16116-16123 NN denotes D3Mit40
T7399 16108-16115 IN denotes between
T7398 16193-16199 VBD denotes showed
T7397 16093-16100 JJ denotes genomic
T7396 16101-16107 NN denotes region
T7395 16091-16092 DT denotes A
T7394 16090-16328 sentence denotes A genomic region between D3Mit40 and D3Mit13, with an estimated peak at position approximately 51 cM, showed a significant linkage to ANA production and weaker linkages to anti-ssDNA and anti-chromatin production (see Table 3; Figure 7).
T7393 16089-16090 . denotes .
T7392 16088-16089 CD denotes 3
T7391 16077-16087 NN denotes Chromosome
T7390 16074-16076 IN denotes on
T7389 16053-16067 NN denotes susceptibility
T7388 16047-16052 JJ denotes major
T7387 16068-16073 NN denotes locus
T7386 16043-16046 CD denotes one
T7385 16038-16042 IN denotes with
T7384 16020-16030 JJ denotes autoimmune
T7383 16031-16037 NNS denotes traits
T7382 16016-16019 DT denotes the
T7381 16013-16015 IN denotes to
T7380 15992-15993 CD denotes 6
T7379 15991-15992 HYPH denotes /
T7378 15986-15991 NN denotes C57BL
T7377 15994-16000 NN denotes strain
T7376 15982-15985 DT denotes the
T7375 15974-15981 NNS denotes cohorts
T7374 15969-15973 DT denotes both
T7373 15966-15968 IN denotes in
T7372 15964-15966 , denotes ,
T7371 15947-15948 HYPH denotes -
T7370 15948-15955 VBN denotes derived
T7369 15944-15947 CD denotes 129
T7368 15956-15964 NNS denotes segments
T7367 15940-15943 DT denotes the
T7366 15937-15939 IN denotes to
T7365 15928-15936 NN denotes addition
T7364 16001-16012 VBD denotes contributed
T7363 15925-15927 IN denotes In
T7362 15180-16090 sentence denotes Figure 6 Auto-Ab Profiles (A) ANA titres in the (129 × C57BL/6)F2.Apcs −/− mice and (129 × C57BL/6)F2 at 1 y of age. A small circle represents one mouse; a large circle, a variable number of animals, as indicated in parentheses. Serum samples were titrated to endpoint. (B) ANA titres in the (129 × C57BL/6)F2.Apcs −/− mice and a selected number of wild-type (129 × C57BL/6)F2 animals carrying the Chromosome 1 region between D1Mit105 and D1Mit223 (80–106 cM) of 129 origin. The symbols are as in (A). (C and D) Anti-chromatin Ab levels expressed in AEUs related to a standard positive sample, which was assigned a value of 100 AEU. The comparison is between the same groups of mice as in (A) and (B), respectively. The symbols are as in (A). In addition to the 129-derived segments, in both cohorts the C57BL/6 strain contributed to the autoimmune traits with one major susceptibility locus on Chromosome 3.
T7361 15179-15180 . denotes .
T7360 15165-15171 JJ denotes murine
T7359 15151-15164 JJ denotes nonautoimmune
T7358 15147-15150 CC denotes and
T7357 15136-15146 JJ denotes autoimmune
T7356 15172-15179 NNS denotes strains
T7355 15128-15135 JJ denotes several
T7354 15120-15127 IN denotes amongst
T7353 15092-15098 VBG denotes coding
T7352 15099-15107 NN denotes sequence
T7351 15087-15091 NN denotes Apcs
T7350 15108-15119 NNS denotes differences
T7349 15084-15086 DT denotes no
T7348 15077-15083 VBD denotes showed
T7347 15072-15076 WDT denotes that
T7346 15070-15071 -RRB- denotes )
T7345 15066-15070 CD denotes 1996
T7344 15065-15066 -LRB- denotes (
T7343 15061-15064 FW denotes al.
T7342 15058-15060 FW denotes et
T7341 15052-15057 NNP denotes Drake
T7340 15049-15051 IN denotes by
T7339 15033-15041 JJ denotes previous
T7338 15042-15048 NN denotes report
T7337 15031-15032 DT denotes a
T7336 15026-15030 IN denotes with
T7335 15015-15025 JJ denotes consistent
T7334 15012-15014 VBZ denotes is
T7333 15007-15011 DT denotes This
T7332 15006-15180 sentence denotes This is consistent with a previous report by Drake et al. (1996) that showed no Apcs coding sequence differences amongst several autoimmune and nonautoimmune murine strains.
T7331 15005-15006 . denotes .
T7330 14997-15005 NNS denotes findings
T7329 14993-14996 PRP$ denotes our
T7328 14989-14992 IN denotes for
T7722 18235-18236 . denotes .
T7721 18222-18229 NN denotes disease
T7720 18230-18235 NN denotes trait
T7719 18217-18221 DT denotes this
T7718 18213-18216 IN denotes for
T7717 18200-18203 NN denotes QTL
T7716 18204-18212 NN denotes analysis
T7715 18196-18199 DT denotes the
T7714 18193-18195 IN denotes of
T7713 18187-18192 NN denotes power
T7712 18183-18186 DT denotes the
T7711 18175-18182 VBZ denotes reduces
T7710 18169-18174 WDT denotes which
T7709 18167-18169 , denotes ,
T7708 18161-18167 NN denotes cohort
T7707 18156-18160 DT denotes each
T7706 18153-18155 IN denotes in
T7705 18148-18152 NNS denotes mice
T7704 18144-18147 DT denotes the
T7703 18141-18143 IN denotes of
T7702 18139-18140 NN denotes %
T7701 18137-18139 CD denotes 20
T7700 18123-18136 RB denotes approximately
T7699 18120-18122 IN denotes in
T7698 18109-18113 RB denotes only
T7697 18105-18108 VBD denotes was
T7696 18086-18104 NN denotes glomerulonephritis
T7695 18083-18085 IN denotes of
T7694 18114-18119 VBN denotes found
T7693 18074-18082 NN denotes evidence
T7692 18061-18073 JJ denotes Histological
T7691 18060-18236 sentence denotes Histological evidence of glomerulonephritis was only found in approximately 20% of the mice in each cohort, which reduces the power of the QTL analysis for this disease trait.
T7690 18059-18060 . denotes .
T7689 18058-18059 -RRB- denotes )
T7688 18046-18058 RB denotes respectively
T7687 18044-18046 , denotes ,
T7686 18038-18039 SYM denotes −
T7685 18037-18038 HYPH denotes /
T7684 18036-18037 SYM denotes −
T7683 18031-18035 NN denotes Apcs
T7682 18027-18030 CC denotes and
T7681 18021-18022 HYPH denotes -
T7680 18022-18026 NN denotes type
T7679 18017-18021 JJ denotes wild
T7678 18040-18044 NNS denotes mice
T7677 18013-18016 DT denotes the
T7676 18010-18012 IN denotes in
T7675 18002-18003 SYM denotes =
T7674 18000-18001 NN denotes p
T7673 17998-18000 , denotes ,
T7672 17994-17998 CD denotes 1.67
T7671 18004-18009 CD denotes 0.021
T7670 17990-17993 NN denotes LOD
T7669 17986-17989 CC denotes and
T7668 17978-17979 SYM denotes =
T7667 17976-17977 NN denotes p
T7666 17974-17976 , denotes ,
T7665 17971-17974 CD denotes 1.3
T7664 17967-17970 NN denotes LOD
T7663 17980-17985 CD denotes 0.049
T7662 17966-17967 -LRB- denotes (
T7661 17957-17958 CD denotes 6
T7660 17956-17957 HYPH denotes /
T7659 17951-17956 NN denotes C57BL
T7658 17959-17965 NN denotes strain
T7657 17947-17950 DT denotes the
T7656 17942-17946 IN denotes from
T7655 17940-17941 -RRB- denotes )
T7654 17933-17937 CD denotes 29.4
T7653 17938-17940 NN denotes cM
T7652 17932-17933 -LRB- denotes (
T7651 17922-17931 NN denotes D17Mit216
T7650 17918-17921 CC denotes and
T7649 17916-17917 -RRB- denotes )
T7648 17909-17913 CD denotes 11.7
T7647 17914-17916 NN denotes cM
T7646 17908-17909 -LRB- denotes (
T7645 17898-17907 NN denotes D17Mit100
T7644 17890-17897 IN denotes between
T7643 17887-17889 CD denotes 17
T7642 17876-17886 NN denotes Chromosome
T7641 17873-17875 IN denotes on
T7640 17869-17872 CD denotes one
T7639 17865-17868 CC denotes and
T7327 14977-14988 NN denotes explanation
T7326 14973-14976 DT denotes the
T7325 14970-14972 VB denotes be
T7324 14967-14969 TO denotes to
T7323 14958-14966 JJ denotes unlikely
T7322 14947-14954 NN denotes protein
T7321 14943-14946 DT denotes the
T7320 14940-14942 IN denotes of
T7319 14921-14931 JJ denotes structural
T7318 14932-14939 NN denotes variant
T7317 14919-14920 DT denotes a
T7316 14955-14957 VBZ denotes is
T7315 14914-14918 IN denotes that
T7314 14903-14913 VBG denotes indicating
T7313 14901-14903 , denotes ,
T7312 14900-14901 -RRB- denotes )
T7311 14891-14894 RB denotes not
T7310 14886-14890 NNS denotes data
T7309 14895-14900 VBN denotes shown
T7308 14885-14886 -LRB- denotes (
T7307 14875-14879 NN denotes Apcs
T7306 14880-14884 NN denotes gene
T7305 14871-14874 DT denotes the
T7304 14868-14870 IN denotes in
T7303 14845-14853 NN denotes sequence
T7302 14838-14844 VBG denotes coding
T7301 14854-14867 NNS denotes polymorphisms
T7300 14834-14837 DT denotes any
T7299 14825-14833 VB denotes identify
T7298 14822-14824 TO denotes to
T7297 14807-14814 NNS denotes strains
T7296 14802-14806 DT denotes both
T7295 14799-14801 IN denotes in
T7294 14785-14791 VBG denotes coding
T7293 14780-14784 NN denotes Apcs
T7292 14773-14779 JJ denotes entire
T7291 14792-14798 NN denotes region
T7290 14769-14772 DT denotes the
T7289 14766-14768 IN denotes of
T7288 14757-14765 NN denotes analysis
T7287 14748-14756 NN denotes sequence
T7286 14746-14748 , denotes ,
T7285 14738-14746 NN denotes addition
T7284 14815-14821 VBD denotes failed
T7283 14735-14737 IN denotes In
T7282 14734-15006 sentence denotes In addition, sequence analysis of the entire Apcs coding region in both strains failed to identify any coding sequence polymorphisms in the Apcs gene (data not shown), indicating that a structural variant of the protein is unlikely to be the explanation for our findings.
T7281 14733-14734 . denotes .
T7280 14732-14733 -RRB- denotes )
T7279 14728-14732 CD denotes 1980
T7278 14724-14727 FW denotes al.
T7277 14721-14723 FW denotes et
T7276 14715-14720 NNP denotes Baltz
T7275 14713-14714 : denotes ;
T7274 14709-14713 CD denotes 1979
T7273 14705-14708 FW denotes al.
T7272 14702-14704 FW denotes et
T7271 14696-14701 NNP denotes Pepys
T7270 14695-14696 -LRB- denotes (
T7269 14680-14684 NN denotes Apcs
T7268 14685-14694 NNS denotes producers
T7267 14676-14679 JJ denotes low
T7266 14673-14675 IN denotes as
T7265 14665-14672 VBN denotes defined
T7264 14650-14656 JJ denotes murine
T7263 14657-14664 NNS denotes strains
T7262 14646-14649 DT denotes the
T7261 14643-14645 IN denotes of
T7260 14639-14642 CD denotes one
T7259 14636-14638 VB denotes be
T7258 14633-14635 TO denotes to
T7257 14619-14623 VBN denotes been
T7256 14608-14618 RB denotes previously
T7255 14604-14607 VBZ denotes has
T7254 14624-14632 VBN denotes reported
T7253 14595-14596 CD denotes 6
T7252 14594-14595 HYPH denotes /
T7251 14589-14594 NN denotes C57BL
T7250 14597-14603 NN denotes strain
T7249 14585-14588 DT denotes The
T7248 14584-14734 sentence denotes The C57BL/6 strain has previously been reported to be one of the murine strains defined as low Apcs producers (Pepys et al. 1979; Baltz et al. 1980).
T7247 14583-14584 . denotes .
T7246 14582-14583 -RRB- denotes )
T7245 14574-14575 SYM denotes <
T7244 14572-14573 NN denotes p
T7243 14570-14571 : denotes ;
T7242 14556-14558 , denotes ,
T7241 14558-14570 RB denotes respectively
T7240 14552-14553 SYM denotes =
T7239 14550-14551 NN denotes n
T7238 14548-14549 : denotes ;
T7237 14547-14548 CD denotes 9
T7236 14546-14547 SYM denotes –
T7235 14543-14545 , denotes ,
T7234 14545-14546 CD denotes 4
T7233 14538-14543 NN denotes range
T7232 14536-14537 : denotes ;
T7231 14535-14536 NN denotes l
T7230 14534-14535 SYM denotes /
T7229 14554-14556 CD denotes 10
T7228 14530-14531 CD denotes 5
T7227 14528-14530 , denotes ,
T7226 14532-14534 NN denotes mg
T7225 14522-14528 NN denotes median
T7224 14515-14521 CC denotes versus
T7223 14510-14511 SYM denotes =
T7222 14508-14509 NN denotes n
T7221 14506-14507 : denotes ;
T7220 14503-14506 CD denotes 208
T7219 14502-14503 SYM denotes –
T7218 14498-14500 , denotes ,
T7217 14500-14502 CD denotes 25
T7216 14493-14498 NN denotes range
T7215 14491-14492 : denotes ;
T7214 14490-14491 NN denotes l
T7213 14489-14490 SYM denotes /
T7212 14512-14514 CD denotes 16
T7211 14484-14486 CD denotes 83
T7210 14482-14484 , denotes ,
T7209 14487-14489 NNS denotes mg
T7208 14476-14482 NN denotes median
T7207 14576-14582 CD denotes 0.0001
T7206 14475-14476 -LRB- denotes (
T7205 14468-14469 CD denotes 6
T7204 14467-14468 HYPH denotes /
T7203 14462-14467 NN denotes C57BL
T7202 14470-14474 NNS denotes mice
T7201 14458-14461 DT denotes the
T7200 14453-14457 IN denotes with
T7199 14444-14452 VBN denotes compared
T7198 14432-14443 NN denotes circulation
T7197 14429-14431 IN denotes in
T7196 14424-14428 NN denotes Apcs
T7195 14421-14423 IN denotes of
T7194 14414-14420 NNS denotes levels
T7193 14407-14413 JJR denotes higher
T7192 14393-14406 RB denotes significantly
T7191 14379-14382 CD denotes 129
T7190 14383-14387 NNS denotes mice
T7189 14375-14378 DT denotes the
T7188 14388-14392 VBP denotes have
T7187 14370-14374 IN denotes that
T7077 13839-13840 HYPH denotes /
T7076 13834-13839 NN denotes C57BL
T7075 13832-13833 SYM denotes ×
T7074 13842-13844 NN denotes F2
T7073 13828-13831 CD denotes 129
T7072 13827-13828 -LRB- denotes (
T7071 13854-13858 NNS denotes mice
T7070 13823-13826 DT denotes all
T7069 13815-13822 IN denotes between
T7068 13806-13814 NNS denotes auto-Abs
T7067 13800-13805 DT denotes these
T7066 13797-13799 IN denotes of
T7065 13790-13796 NNS denotes levels
T7064 13786-13789 DT denotes the
T7063 13777-13785 VBD denotes compared
T7062 13774-13776 PRP denotes We
T7061 13773-14040 sentence denotes We compared the levels of these auto-Abs between all (129 × C57BL/6)F2.Apcs −/− mice and a group of 33 wild-type mice that were selected for being homozygous 129 in the region of Chromosome 1 between microsatellites D1Mit105 and D1Mit 223 (80–106 cM) (Figure 6A–6D).
T7060 13772-13773 . denotes .
T7059 13766-13772 PRP denotes itself
T7058 13756-13760 NN denotes Apcs
T7057 13748-13755 VBN denotes mutated
T7056 13761-13765 NN denotes gene
T7055 13744-13747 DT denotes the
T7054 13741-13743 IN denotes by
T7053 13734-13740 VBN denotes caused
T7052 13729-13733 IN denotes than
T7051 13722-13728 RB denotes rather
T7050 13720-13722 , denotes ,
T7049 13711-13715 NN denotes Apcs
T7048 13703-13710 VBN denotes mutated
T7047 13716-13720 NN denotes gene
T7046 13699-13702 DT denotes the
T7045 13687-13698 VBG denotes surrounding
T7044 13676-13679 CD denotes 129
T7043 13670-13675 VBN denotes fixed
T7042 13680-13686 NN denotes region
T7041 13666-13669 DT denotes the
T7040 13659-13665 IN denotes within
T7039 13657-13658 -RRB- denotes )
T7038 13656-13657 AFX denotes s
T7037 13655-13656 -LRB- denotes (
T7036 13651-13655 NN denotes gene
T7035 13649-13650 DT denotes a
T7034 13646-13648 IN denotes by
T7033 13634-13638 VBD denotes were
T7032 13627-13628 SYM denotes −
T7031 13626-13627 HYPH denotes /
T7030 13625-13626 SYM denotes −
T7029 13620-13624 NN denotes Apcs
T7028 13629-13633 NNS denotes mice
T7027 13616-13619 DT denotes the
T7026 13613-13615 IN denotes in
T7025 13604-13612 VBN denotes observed
T7024 13601-13603 NN denotes Ab
T7023 13586-13600 JJ denotes anti-chromatin
T7022 13582-13585 CC denotes and
T7021 13578-13581 NN denotes ANA
T7020 13575-13577 IN denotes of
T7019 13558-13567 VBN denotes increased
T7018 13568-13574 NNS denotes levels
T7017 13554-13557 DT denotes the
T7016 13639-13645 VBN denotes caused
T7015 13546-13553 IN denotes whether
T7014 13530-13532 PRP denotes we
T7013 13528-13530 , denotes ,
T7012 13516-13528 NNS denotes observations
T7011 13510-13515 DT denotes these
T7010 13507-13509 IN denotes by
T7009 13533-13545 VBD denotes investigated
T7008 13500-13506 VBN denotes Guided
T7007 12513-13773 sentence denotes Figure 4 Interval Mapping Scans Showing QTL on Chromosome 1 with Anti-dsDNA and Anti-ssDNA Abs Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines indicate the threshold over which linkage was considered suggestive, dashed lines indicate the threshold over which linkage was considered significant, and dotted/dashed lines indicate highly significant linkage, as defined in Materials and Methods. See Table 3 for additional details. Figure 5 Interval Mapping Scans Showing QTL on Chromosome 1 with ANA and Anti-Chromatin Abs Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines indicate the threshold over which linkage was considered suggestive, and dashed lines indicate the threshold over which linkage was considered significant, as defined in Materials and Methods. See Table 3 for additional details. Guided by these observations, we investigated whether the increased levels of ANA and anti-chromatin Ab observed in the Apcs −/− mice were caused by a gene(s) within the fixed 129 region surrounding the mutated Apcs gene, rather than caused by the mutated Apcs gene itself.
T7006 12512-12513 . denotes .
T7005 12500-12505 NN denotes mouse
T7004 12496-12499 CD denotes 129
T7003 12506-12512 NN denotes strain
T7422 16251-16259 NNS denotes linkages
T7421 16244-16250 JJR denotes weaker
T7420 16240-16243 CC denotes and
T7419 16229-16239 NN denotes production
T7418 16225-16228 NN denotes ANA
T7417 16222-16224 IN denotes to
T7416 16202-16213 JJ denotes significant
T7415 16214-16221 NN denotes linkage
T7414 16200-16201 DT denotes a
T7413 16191-16193 , denotes ,
T7412 16186-16188 CD denotes 51
T7411 16172-16185 RB denotes approximately
T7410 16189-16191 NNS denotes cM
T7409 16163-16171 NN denotes position
T7408 16160-16162 IN denotes at
T7407 16145-16154 VBN denotes estimated
T7406 16155-16159 NN denotes peak
T7405 16142-16144 DT denotes an
T7404 16137-16141 IN denotes with
T7403 16135-16137 , denotes ,
T7002 12492-12495 DT denotes the
T7001 12487-12491 IN denotes from
T7000 12466-12473 JJ denotes genetic
T6999 12458-12465 JJ denotes complex
T6998 12453-12457 RBR denotes more
T6997 12474-12486 NN denotes contribution
T6996 12451-12452 DT denotes a
T6995 12440-12450 VBG denotes indicating
T6994 12438-12440 , denotes ,
T6993 12437-12438 CD denotes 1
T6992 12426-12436 NN denotes Chromosome
T6991 12423-12425 IN denotes on
T6990 12414-12422 NNS denotes segments
T6989 12408-12413 JJ denotes other
T6988 12405-12407 IN denotes to
T6987 12393-12397 RB denotes also
T6986 12389-12392 VBD denotes was
T6985 12375-12377 NN denotes Ab
T6984 12364-12374 JJ denotes anti-ssDNA
T6983 12361-12363 CC denotes or
T6982 12378-12388 NN denotes production
T6981 12350-12360 JJ denotes anti-dsDNA
T6980 12348-12350 , denotes ,
T6979 12339-12343 NN denotes Apcs
T6978 12344-12348 NN denotes gene
T6977 12335-12338 DT denotes the
T6976 12330-12334 IN denotes near
T6975 12327-12329 NN denotes cM
T6974 12324-12326 CD denotes 90
T6973 12310-12323 RB denotes approximately
T6972 12301-12309 NN denotes position
T6971 12299-12300 DT denotes a
T6970 12296-12298 IN denotes at
T6969 12286-12295 VBG denotes occurring
T6968 12271-12280 VBN denotes estimated
T6967 12281-12285 NN denotes peak
T6966 12268-12270 DT denotes an
T6965 12263-12267 IN denotes with
T6964 12261-12263 , denotes ,
T6963 12260-12261 CD denotes 1
T6962 12249-12259 NN denotes Chromosome
T6961 12246-12248 IN denotes of
T6960 12229-12238 JJ denotes telomeric
T6959 12239-12245 NN denotes region
T6958 12225-12228 DT denotes the
T6957 12222-12224 IN denotes to
T6956 12217-12221 RB denotes only
T6955 12196-12207 JJ denotes significant
T6954 12193-12195 CC denotes or
T6953 12208-12216 NNS denotes linkages
T6952 12182-12192 JJ denotes suggestive
T6951 12165-12167 NN denotes Ab
T6950 12150-12164 JJ denotes anti-chromatin
T6949 12146-12149 CC denotes and
T6948 12168-12174 NNS denotes levels
T6947 12142-12145 NN denotes ANA
T6946 12175-12181 VBD denotes showed
T6945 12135-12141 IN denotes whilst
T6944 12133-12135 , denotes ,
T6943 12398-12404 VBN denotes linked
T6942 12120-12133 RB denotes Interestingly
T6941 12119-12513 sentence denotes Interestingly, whilst ANA and anti-chromatin Ab levels showed suggestive or significant linkages only to the telomeric region of Chromosome 1, with an estimated peak occurring at a position approximately 90 cM near the Apcs gene, anti-dsDNA or anti-ssDNA Ab production was also linked to other segments on Chromosome 1, indicating a more complex genetic contribution from the 129 mouse strain.
T6940 12118-12119 . denotes .
T6939 12117-12118 -RRB- denotes )
T6938 12116-12117 CD denotes 5
T6937 12112-12115 CC denotes and
T6936 12102-12109 NNS denotes Figures
T6935 12100-12101 : denotes ;
T6934 12099-12100 CD denotes 3
T6933 12093-12098 NN denotes Table
T6932 12089-12092 VB denotes see
T6931 12110-12111 CD denotes 4
T6930 12088-12089 -LRB- denotes (
T6929 12075-12080 NN denotes mouse
T6928 12071-12074 CD denotes 129
T6927 12081-12087 NN denotes strain
T6926 12067-12070 DT denotes the
T6925 12062-12066 IN denotes from
T6924 12050-12053 RB denotes all
T6923 12045-12049 VBD denotes were
T6922 12054-12061 VBN denotes derived
T6921 12037-12044 NNS denotes regions
T6920 12031-12036 DT denotes these
T6919 12027-12030 CC denotes and
T6918 12025-12027 , denotes ,
T6917 12006-12017 JJ denotes serological
T6916 12018-12025 NNS denotes markers
T6915 11998-12005 NN denotes disease
T6914 11995-11997 IN denotes to
T6913 11987-11994 NN denotes linkage
T6912 11982-11986 IN denotes with
T6911 11980-11981 CD denotes 1
T6910 11969-11979 NN denotes Chromosome
T6909 11966-11968 IN denotes on
T6908 11956-11965 NNS denotes intervals
T6907 11948-11955 JJ denotes several
T6906 11937-11947 VBD denotes identified
T6905 11926-11927 -RRB- denotes )
T6904 11923-11926 NN denotes QTL
T6903 11922-11923 -LRB- denotes (
T6902 11908-11913 NN denotes trait
T6901 11914-11921 NN denotes linkage
T6900 11895-11907 JJ denotes quantitative
T6899 11928-11936 NN denotes analysis
T6898 11891-11894 DT denotes The
T6897 10227-12119 sentence denotes Figure 1 Linkage of Chromosome 2 with ANA and Anti-Chromatin Abs in (129 × C57BL/6)F2.Apcs−/− Mice These associations were not detected in (129 × C57BL/6)F2 animals. Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines and the dashed line indicate the threshold over which linkages were considered suggestive or significant, respectively, as defined in Materials and Methods. Figure 3 Linkage of Chromosome 4 with Anti-dsDNA Abs The estimated peak in (129 × C57BL/6)F2 mice was at position 51.3 cM, whilst in the (129 × C57BL/6)F2.Apcs−/−animals it was was at position 71 cM, indicating that most likely these were two independent loci. Centimorgan positions were deduced by interval mapping, anchoring marker locations to data from http://www.informatics.jax.org. Dotted lines the indicate threshold over which linkage was considered suggestive, as defined in Materials and Methods. Table 3 Summary of Genome-Wide Linkage Analysis in Apcs −/− and Wild-Type (129 × C57BL/6)F2 Female Mice a Suggestive linkage b Significant linkage c Highly significant linkage as defined in the material and method section Chr, Chromosome; Est. Peak, Estimated Peak; LOD, logarithm of odds; N/A, not applicable Chromosomes where linkages were not present in both experimental groups are not illustrated. See Materials and Methods for details. The oligonucleotide sequences and approximate positions of the microsatellite markers used were taken from the Mouse Genome Database, Mouse Genome Informatics, Jackson Laboratory, Bar Harbor, Maine, United States (http://www.informatics.jax.org) The quantitative trait linkage (QTL) analysis identified several intervals on Chromosome 1 with linkage to disease serological markers, and these regions were all derived from the 129 mouse strain (see Table 3; Figures 4 and 5).
T7186 14361-14363 PRP denotes we
T7185 14359-14361 , denotes ,
T7184 14348-14359 NN denotes explanation
T7183 14343-14347 DT denotes this
T7182 14338-14342 IN denotes with
T7181 14364-14369 VBD denotes found
T7180 14327-14337 JJ denotes Consistent
T7179 14326-14584 sentence denotes Consistent with this explanation, we found that the 129 mice have significantly higher levels of Apcs in circulation compared with the C57BL/6 mice (median, 83 mg/l; range, 25–208; n = 16 versus median, 5 mg/l; range, 4–9; n = 10, respectively; p < 0.0001).
T7178 14325-14326 . denotes .
T7177 14323-14325 NN denotes Ab
T7176 14308-14322 JJ denotes anti-chromatin
T7175 14304-14307 CC denotes and
T7174 14300-14303 NN denotes ANA
T7173 14297-14299 IN denotes of
T7172 14286-14296 NN denotes production
T7171 14282-14285 DT denotes the
T7170 14268-14271 VBD denotes was
T7169 14263-14267 NN denotes Apcs
T7168 14260-14262 IN denotes of
T7167 14255-14259 NN denotes lack
T7166 14251-14254 DT denotes the
T7165 14247-14250 RB denotes not
T7164 14243-14246 CC denotes and
T7163 14227-14228 HYPH denotes -
T7162 14228-14235 VBN denotes derived
T7161 14224-14227 CD denotes 129
T7160 14236-14242 NN denotes region
T7159 14220-14223 DT denotes the
T7158 14218-14220 , denotes ,
T7157 14212-14218 RB denotes likely
T7156 14207-14211 RBS denotes most
T7155 14205-14207 , denotes ,
T7154 14272-14281 VBG denotes mediating
T7153 14201-14205 IN denotes that
T7152 14188-14200 VBZ denotes demonstrates
T7151 14181-14187 NN denotes result
T7150 14176-14180 DT denotes This
T7149 14175-14326 sentence denotes This result demonstrates that, most likely, the 129-derived region and not the lack of Apcs was mediating the production of ANA and anti-chromatin Ab.
T7148 14174-14175 . denotes .
T7147 14155-14167 JJ denotes experimental
T7146 14151-14154 CD denotes two
T7145 14168-14174 NNS denotes groups
T7144 14147-14150 DT denotes the
T7143 14139-14146 IN denotes between
T7142 14115-14126 JJ denotes significant
T7141 14127-14138 NNS denotes differences
T7140 14112-14114 DT denotes no
T7139 14094-14104 NN denotes comparison
T7138 14089-14093 DT denotes this
T7137 14087-14089 , denotes ,
T7136 14086-14087 CD denotes 1
T7135 14080-14085 NN denotes Table
T7134 14077-14079 IN denotes in
T7133 14068-14076 VBN denotes reported
T7132 14060-14067 NNS denotes results
T7131 14056-14059 DT denotes the
T7130 14053-14055 IN denotes to
T7129 14044-14052 NN denotes contrast
T7128 14105-14111 VBD denotes showed
T7127 14041-14043 IN denotes In
T7126 14040-14175 sentence denotes In contrast to the results reported in Table 1, this comparison showed no significant differences between the two experimental groups.
T7125 14039-14040 . denotes .
T7124 14038-14039 -RRB- denotes )
T7123 14036-14038 NN denotes 6D
T7122 14035-14036 SYM denotes –
T7121 14026-14032 NN denotes Figure
T7120 14033-14035 NN denotes 6A
T7119 14025-14026 -LRB- denotes (
T7118 14023-14024 -RRB- denotes )
T7117 14016-14017 SYM denotes –
T7116 14017-14020 CD denotes 106
T7115 14014-14016 CD denotes 80
T7114 14021-14023 NN denotes cM
T7113 14013-14014 -LRB- denotes (
T7112 14009-14012 CD denotes 223
T7111 14003-14008 NN denotes D1Mit
T7110 13999-14002 CC denotes and
T7109 13990-13998 NN denotes D1Mit105
T7108 13974-13989 NNS denotes microsatellites
T7107 13966-13973 IN denotes between
T7106 13964-13965 CD denotes 1
T7105 13953-13963 NN denotes Chromosome
T7104 13950-13952 IN denotes of
T7103 13943-13949 NN denotes region
T7102 13939-13942 DT denotes the
T7101 13936-13938 IN denotes in
T7100 13932-13935 CD denotes 129
T7099 13921-13931 JJ denotes homozygous
T7098 13915-13920 VBG denotes being
T7097 13911-13914 IN denotes for
T7096 13897-13901 VBD denotes were
T7095 13902-13910 VBN denotes selected
T7094 13892-13896 WDT denotes that
T7093 13881-13882 HYPH denotes -
T7092 13882-13886 NN denotes type
T7091 13877-13881 JJ denotes wild
T7090 13887-13891 NNS denotes mice
T7089 13874-13876 CD denotes 33
T7088 13871-13873 IN denotes of
T7087 13865-13870 NN denotes group
T7086 13863-13864 DT denotes a
T7085 13859-13862 CC denotes and
T7084 13852-13853 SYM denotes −
T7083 13851-13852 HYPH denotes /
T7082 13850-13851 SYM denotes −
T7081 13845-13849 NN denotes Apcs
T7080 13844-13845 HYPH denotes .
T7079 13841-13842 -RRB- denotes )
T7078 13840-13841 CD denotes 6
T573 96-97 HYPH denotes -
T574 106-110 NNS denotes Mice
T555 0-11 JJ denotes Spontaneous
T556 12-24 NN denotes Autoimmunity
T557 0-110 sentence denotes Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice
T558 49-61 NNS denotes Implications
T559 25-27 IN denotes in
T560 28-31 CD denotes 129
T561 44-48 NNS denotes Mice
T562 32-35 CC denotes and
T563 36-41 NN denotes C57BL
T564 41-42 HYPH denotes /
T565 42-43 CD denotes 6
T566 48-49 : denotes —
T567 62-65 IN denotes for
T568 66-78 NN denotes Autoimmunity
T569 79-88 VBN denotes Described
T570 89-91 IN denotes in
T571 92-96 NN denotes Gene
T572 97-105 VBN denotes Targeted
T577 110-285 sentence denotes Gene-Targeted Mice and Autoimmunity Abstract Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role.
T578 157-165 JJ denotes Systemic
T579 172-185 NN denotes erythematosus
T580 166-171 NN denotes lupus
T581 192-194 VBZ denotes is
T582 186-187 -LRB- denotes (
T583 187-190 NN denotes SLE
T584 190-191 -RRB- denotes )
T585 195-196 DT denotes a
T586 220-228 NN denotes disorder
T587 197-208 JJ denotes multisystem
T588 209-219 JJ denotes autoimmune
T589 229-231 IN denotes in
T590 262-266 VBP denotes play
T591 232-237 WDT denotes which
T592 238-245 JJ denotes complex
T593 254-261 NNS denotes factors
T594 246-253 JJ denotes genetic
T595 267-269 DT denotes an
T596 280-284 NN denotes role
T597 270-279 JJ denotes important
T598 284-285 . denotes .
T599 285-414 sentence denotes Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of disease.
T600 286-293 JJ denotes Several
T601 294-301 NNS denotes strains
T602 334-342 VBN denotes reported
T603 302-304 IN denotes of
T604 305-309 NN denotes gene
T605 310-318 VBN denotes targeted
T606 309-310 HYPH denotes -
T607 319-323 NNS denotes mice
T608 324-328 VBP denotes have
T609 329-333 VBN denotes been
T610 343-345 TO denotes to
T611 346-353 VB denotes develop
T612 354-357 NN denotes SLE
T613 357-359 , denotes ,
T614 359-370 VBG denotes implicating
T615 371-374 DT denotes the
T616 380-385 NNS denotes genes
T617 375-379 JJ denotes null
T618 386-388 IN denotes in
T619 389-392 DT denotes the
T620 393-402 NN denotes causation
T621 403-405 IN denotes of
T622 406-413 NN denotes disease
T623 413-414 . denotes .
T624 414-555 sentence denotes However, hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, develop spontaneous autoimmunity.
T625 415-422 RB denotes However
T626 522-529 VBP denotes develop
T627 422-424 , denotes ,
T628 424-430 JJ denotes hybrid
T629 431-438 NNS denotes strains
T630 439-446 IN denotes between
T631 447-450 CD denotes 129
T632 463-467 NNS denotes mice
T633 451-454 CC denotes and
T634 455-460 NN denotes C57BL
T635 460-461 HYPH denotes /
T636 461-462 CD denotes 6
T637 467-469 , denotes ,
T638 469-475 RB denotes widely
T639 476-480 VBN denotes used
T645 507-515 VBN denotes targeted
T640 481-483 IN denotes in
T641 484-487 DT denotes the
T642 488-498 NN denotes generation
T643 499-501 IN denotes of
T644 502-506 NN denotes gene
T646 506-507 HYPH denotes -
T647 516-520 NNS denotes mice
T648 520-522 , denotes ,
T649 530-541 JJ denotes spontaneous
T650 542-554 NN denotes autoimmunity
T651 554-555 . denotes .
T652 555-666 sentence denotes Furthermore, the genetic background markedly influences the autoimmune phenotype of SLE in gene-targeted mice.
T653 556-567 RB denotes Furthermore
T654 601-611 VBZ denotes influences
T655 567-569 , denotes ,
T656 569-572 DT denotes the
T657 581-591 NN denotes background
T658 573-580 JJ denotes genetic
T659 592-600 RB denotes markedly
T660 612-615 DT denotes the
T661 627-636 NN denotes phenotype
T662 616-626 JJ denotes autoimmune
T663 637-639 IN denotes of
T664 640-643 NN denotes SLE
T665 644-646 IN denotes in
T666 647-651 NN denotes gene
T667 652-660 VBN denotes targeted
T668 651-652 HYPH denotes -
T669 661-665 NNS denotes mice
T670 665-666 . denotes .
T671 666-822 sentence denotes This suggests an important role in the expression of autoimmunity of as-yet-uncharacterised background genes originating from these parental mouse strains.
T672 667-671 DT denotes This
T673 672-680 VBZ denotes suggests
T674 681-683 DT denotes an
T675 694-698 NN denotes role
T676 684-693 JJ denotes important
T677 699-701 IN denotes in
T678 702-705 DT denotes the
T679 706-716 NN denotes expression
T680 717-719 IN denotes of
T681 720-732 NN denotes autoimmunity
T682 733-735 IN denotes of
T683 736-738 RB denotes as
T684 739-742 RB denotes yet
T685 738-739 HYPH denotes -
T686 743-758 JJ denotes uncharacterised
T687 742-743 HYPH denotes -
T688 770-775 NNS denotes genes
T689 759-769 NN denotes background
T690 776-787 VBG denotes originating
T691 788-792 IN denotes from
T692 793-798 DT denotes these
T693 814-821 NNS denotes strains
T694 799-807 JJ denotes parental
T695 808-813 NN denotes mouse
T696 821-822 . denotes .
T697 822-992 sentence denotes Using genome-wide linkage analysis, we identified several susceptibility loci, derived from 129 and C57BL/6 mice, mapped in the lupus-prone hybrid (129 × C57BL/6) model.
T698 823-828 VBG denotes Using
T699 862-872 VBD denotes identified
T700 829-835 NN denotes genome
T701 836-840 JJ denotes wide
T702 835-836 HYPH denotes -
T703 849-857 NN denotes analysis
T704 841-848 NN denotes linkage
T705 857-859 , denotes ,
T706 859-861 PRP denotes we
T707 873-880 JJ denotes several
T708 896-900 NNS denotes loci
T709 881-895 NN denotes susceptibility
T710 900-902 , denotes ,
T711 902-909 VBN denotes derived
T712 910-914 IN denotes from
T713 915-918 CD denotes 129
T714 931-935 NNS denotes mice
T715 919-922 CC denotes and
T716 923-928 NN denotes C57BL
T717 928-929 HYPH denotes /
T718 929-930 CD denotes 6
T719 935-937 , denotes ,
T720 937-943 VBN denotes mapped
T721 944-946 IN denotes in
T722 947-950 DT denotes the
T723 986-991 NN denotes model
T724 951-956 NN denotes lupus
T725 957-962 JJ denotes prone
T726 956-957 HYPH denotes -
T727 963-969 NN denotes hybrid
T728 970-971 -LRB- denotes (
T729 971-974 CD denotes 129
T730 975-976 SYM denotes ×
T731 977-982 NN denotes C57BL
T732 982-983 HYPH denotes /
T733 983-984 CD denotes 6
T734 984-985 -RRB- denotes )
T735 991-992 . denotes .
T736 992-1234 sentence denotes By creating a C57BL/6 congenic strain carrying a 129-derived Chromosome 1 segment, we found that this 129 interval was sufficient to mediate the loss of tolerance to nuclear antigens, which had previously been attributed to a disrupted gene.
T737 993-995 IN denotes By
T738 1079-1084 VBD denotes found
T739 996-1004 VBG denotes creating
T740 1005-1006 DT denotes a
T741 1024-1030 NN denotes strain
T742 1007-1012 NN denotes C57BL
T743 1012-1013 HYPH denotes /
T744 1013-1014 CD denotes 6
T745 1015-1023 JJ denotes congenic
T746 1031-1039 VBG denotes carrying
T747 1040-1041 DT denotes a
T748 1067-1074 NN denotes segment
T749 1042-1045 CD denotes 129
T750 1046-1053 VBN denotes derived
T751 1045-1046 HYPH denotes -
T752 1054-1064 NN denotes Chromosome
T753 1065-1066 CD denotes 1
T754 1074-1076 , denotes ,
T755 1076-1078 PRP denotes we
T756 1085-1089 IN denotes that
T757 1108-1111 VBD denotes was
T758 1090-1094 DT denotes this
T759 1099-1107 NN denotes interval
T760 1095-1098 CD denotes 129
T761 1112-1122 JJ denotes sufficient
T762 1123-1125 TO denotes to
T763 1126-1133 VB denotes mediate
T764 1134-1137 DT denotes the
T765 1138-1142 NN denotes loss
T766 1143-1145 IN denotes of
T767 1146-1155 NN denotes tolerance
T768 1156-1158 IN denotes to
T769 1159-1166 JJ denotes nuclear
T770 1167-1175 NNS denotes antigens
T771 1175-1177 , denotes ,
T772 1177-1182 WDT denotes which
T773 1203-1213 VBN denotes attributed
T774 1183-1186 VBD denotes had
T775 1187-1197 RB denotes previously
T776 1198-1202 VBN denotes been
T777 1214-1216 IN denotes to
T778 1217-1218 DT denotes a
T779 1229-1233 NN denotes gene
T780 1219-1228 VBN denotes disrupted
T781 1233-1234 . denotes .
T782 1234-1371 sentence denotes These results demonstrate important epistatic modifiers of autoimmunity in 129 and C57BL/6 mouse strains, widely used in gene targeting.
T783 1235-1240 DT denotes These
T784 1241-1248 NNS denotes results
T785 1249-1260 VBP denotes demonstrate
T786 1261-1270 JJ denotes important
T787 1281-1290 NNS denotes modifiers
T788 1271-1280 JJ denotes epistatic
T789 1291-1293 IN denotes of
T790 1294-1306 NN denotes autoimmunity
T791 1307-1309 IN denotes in
T792 1310-1313 CD denotes 129
T793 1332-1339 NNS denotes strains
T794 1314-1317 CC denotes and
T795 1318-1323 NN denotes C57BL
T796 1323-1324 HYPH denotes /
T797 1324-1325 CD denotes 6
T798 1326-1331 NN denotes mouse
T799 1339-1341 , denotes ,
T800 1341-1347 RB denotes widely
T801 1348-1352 VBN denotes used
T802 1353-1355 IN denotes in
T803 1356-1360 NN denotes gene
T804 1361-1370 NN denotes targeting
T805 1370-1371 . denotes .
T806 1371-1511 sentence denotes These background gene influences may account for some, or even all, of the autoimmune traits described in some gene-targeted models of SLE.
T807 1372-1377 DT denotes These
T808 1394-1404 NNS denotes influences
T809 1378-1388 NN denotes background
T810 1389-1393 NN denotes gene
T811 1409-1416 VB denotes account
T812 1405-1408 MD denotes may
T813 1417-1420 IN denotes for
T814 1421-1425 DT denotes some
T815 1425-1427 , denotes ,
T816 1427-1429 CC denotes or
T817 1430-1434 RB denotes even
T818 1435-1438 DT denotes all
T819 1438-1440 , denotes ,
T820 1440-1442 IN denotes of
T821 1443-1446 DT denotes the
T822 1458-1464 NNS denotes traits
T823 1447-1457 JJ denotes autoimmune
T824 1465-1474 VBN denotes described
T825 1475-1477 IN denotes in
T826 1478-1482 DT denotes some
T827 1497-1503 NNS denotes models
T828 1483-1487 NN denotes gene
T829 1488-1496 VBN denotes targeted
T830 1487-1488 HYPH denotes -
T831 1504-1506 IN denotes of
T832 1507-1510 NN denotes SLE
T833 1510-1511 . denotes .
T3253 4302-4306 IN denotes with
T3254 4338-4348 VBN denotes associated
T3255 4307-4312 WDT denotes which
T3256 4313-4317 JJ denotes such
T3257 4318-4327 NNS denotes mutations
T3258 4328-4332 VBP denotes have
T3259 4333-4337 VBN denotes been
T3260 4349-4353 IN denotes with
T3070 3253-3256 DT denotes the
T3071 3257-3262 NNS denotes genes
T3072 3263-3275 VBG denotes contributing
T3261 4354-4356 DT denotes an
T3262 4368-4377 NN denotes phenotype
T3263 4357-4367 JJ denotes autoimmune
T3264 4377-4378 . denotes .
T2804 1730-1738 JJ denotes Systemic
T2805 1745-1758 NN denotes erythematosus
T2806 1739-1744 NN denotes lupus
T2807 1765-1767 VBZ denotes is
T2808 1759-1760 -LRB- denotes (
T2809 1760-1763 NN denotes SLE
T2810 1763-1764 -RRB- denotes )
T2811 1768-1769 DT denotes a
T2812 1789-1796 NN denotes disease
T2813 1770-1777 JJ denotes chronic
T2814 1778-1788 JJ denotes autoimmune
T2815 1797-1810 VBN denotes characterised
T2816 1811-1813 IN denotes by
T2817 1814-1817 DT denotes the
T2818 1818-1828 NN denotes production
T2819 1829-1831 IN denotes of
T2820 1832-1846 NNS denotes autoantibodies
T2821 1847-1848 -LRB- denotes (
T2822 1848-1856 NNS denotes auto-Abs
T2823 1856-1857 -RRB- denotes )
T2824 1858-1865 IN denotes against
T2825 1866-1867 DT denotes a
T2826 1873-1881 NN denotes spectrum
T2827 1868-1872 JJ denotes wide
T2828 1882-1884 IN denotes of
T2829 1885-1889 NN denotes self
T2830 1890-1898 NNS denotes antigens
T2831 1889-1890 HYPH denotes -
T2832 1898-1900 , denotes ,
T2833 1900-1906 RB denotes mainly
T2834 1907-1911 IN denotes from
T2835 1912-1923 JJ denotes subcellular
T2836 1924-1936 NNS denotes compartments
T2837 1936-1938 , denotes ,
T2838 1938-1948 RB denotes especially
T2839 1958-1965 NN denotes nucleus
T2840 1949-1952 DT denotes the
T2841 1953-1957 NN denotes cell
T2842 1965-1966 . denotes .
T2843 1966-2163 sentence denotes Genetic predisposition is an important contributor to susceptibility to SLE in both humans and animals (Vyse and Todd 1996; Harley et al. 1998; Theofilopoulos and Kono 1999; Wakeland et al. 2001).
T2844 1967-1974 JJ denotes Genetic
T2845 1975-1989 NN denotes predisposition
T2846 1990-1992 VBZ denotes is
T2847 1993-1995 DT denotes an
T2848 2006-2017 NN denotes contributor
T2849 1996-2005 JJ denotes important
T2850 2018-2020 IN denotes to
T2851 2021-2035 NN denotes susceptibility
T2852 2036-2038 IN denotes to
T2853 2039-2042 NN denotes SLE
T2854 2043-2045 IN denotes in
T2855 2046-2050 CC denotes both
T2856 2051-2057 NNS denotes humans
T2857 2058-2061 CC denotes and
T2858 2062-2069 NNS denotes animals
T2859 2070-2071 -LRB- denotes (
T2860 2071-2075 NNP denotes Vyse
T2861 2076-2079 CC denotes and
T2862 2080-2084 NNP denotes Todd
T2863 2085-2089 CD denotes 1996
T2864 2089-2090 : denotes ;
T2865 2091-2097 NNP denotes Harley
T2866 2098-2100 FW denotes et
T2867 2101-2104 FW denotes al.
T2868 2105-2109 CD denotes 1998
T2869 2109-2110 : denotes ;
T2870 2111-2125 NNP denotes Theofilopoulos
T2871 2126-2129 CC denotes and
T2872 2130-2134 NNP denotes Kono
T2873 2135-2139 CD denotes 1999
T2874 2139-2140 : denotes ;
T2875 2141-2149 NNP denotes Wakeland
T2876 2150-2152 FW denotes et
T2877 2153-2156 FW denotes al.
T2878 2157-2161 CD denotes 2001
T2879 2161-2162 -RRB- denotes )
T2880 2162-2163 . denotes .
T2881 2163-2321 sentence denotes Genes in multiple pathways participate in mediating disease pathogenesis, and epistatic interactions amongst these genes influence the expression of disease.
T2882 2164-2169 NNS denotes Genes
T2883 2191-2202 VBP denotes participate
T2884 2170-2172 IN denotes in
T2885 2173-2181 JJ denotes multiple
T2886 2182-2190 NNS denotes pathways
T2887 2203-2205 IN denotes in
T2888 2206-2215 VBG denotes mediating
T2889 2216-2223 NN denotes disease
T2890 2224-2236 NN denotes pathogenesis
T2891 2236-2238 , denotes ,
T2892 2238-2241 CC denotes and
T2893 2242-2251 JJ denotes epistatic
T2894 2252-2264 NNS denotes interactions
T2895 2285-2294 VBP denotes influence
T2896 2265-2272 IN denotes amongst
T2897 2273-2278 DT denotes these
T2898 2279-2284 NNS denotes genes
T2899 2295-2298 DT denotes the
T2900 2299-2309 NN denotes expression
T2901 2310-2312 IN denotes of
T2902 2313-2320 NN denotes disease
T2903 2320-2321 . denotes .
T2904 2321-2585 sentence denotes In this context, both genetic linkage studies in spontaneous lupus-prone models and synthetic murine models of autoimmunity generated by targeted disruption of specific genes modulating the immune system have widely been used to investigate the complexity of SLE.
T2905 2322-2324 IN denotes In
T2906 2543-2547 VBN denotes used
T2907 2325-2329 DT denotes this
T2908 2330-2337 NN denotes context
T2909 2337-2339 , denotes ,
T2910 2339-2343 CC denotes both
T2911 2360-2367 NNS denotes studies
T2912 2344-2351 JJ denotes genetic
T2913 2352-2359 NN denotes linkage
T2914 2368-2370 IN denotes in
T2915 2371-2382 JJ denotes spontaneous
T2916 2395-2401 NNS denotes models
T2917 2383-2388 NN denotes lupus
T2918 2389-2394 JJ denotes prone
T2919 2388-2389 HYPH denotes -
T2920 2402-2405 CC denotes and
T2921 2406-2415 JJ denotes synthetic
T2922 2423-2429 NNS denotes models
T2923 2416-2422 JJ denotes murine
T2924 2430-2432 IN denotes of
T2925 2433-2445 NN denotes autoimmunity
T2926 2446-2455 VBN denotes generated
T2927 2456-2458 IN denotes by
T2928 2459-2467 VBN denotes targeted
T2929 2468-2478 NN denotes disruption
T2930 2479-2481 IN denotes of
T2931 2482-2490 JJ denotes specific
T2932 2491-2496 NNS denotes genes
T2933 2497-2507 VBG denotes modulating
T2934 2508-2511 DT denotes the
T2935 2519-2525 NN denotes system
T2936 2512-2518 JJ denotes immune
T2937 2526-2530 VBP denotes have
T2938 2531-2537 RB denotes widely
T2939 2538-2542 VBN denotes been
T2940 2548-2550 TO denotes to
T2941 2551-2562 VB denotes investigate
T2942 2563-2566 DT denotes the
T2943 2567-2577 NN denotes complexity
T2944 2578-2580 IN denotes of
T2945 2581-2584 NN denotes SLE
T2946 2584-2585 . denotes .
T2947 2585-2940 sentence denotes The best-studied strains of mice that spontaneously develop a lupus-like pathology are the New Zealand Black/New Zealand White hybrid strain (NZB/WF1); the MRL/Mp lpr/lpr strain, which carries the lpr mutation of the FAS receptor gene; and the BXSB strain, which carries the Y chromosome autoimmune accelerator (Yaa) gene (Theofilopoulos and Dixon 1985).
T2948 2586-2589 DT denotes The
T2949 2603-2610 NNS denotes strains
T2950 2590-2594 RBS denotes best
T2951 2595-2602 VBN denotes studied
T2952 2594-2595 HYPH denotes -
T2953 2669-2672 VBP denotes are
T2954 2611-2613 IN denotes of
T2955 2614-2618 NNS denotes mice
T2956 2619-2623 WDT denotes that
T2957 2638-2645 VBP denotes develop
T2958 2624-2637 RB denotes spontaneously
T2959 2646-2647 DT denotes a
T2960 2659-2668 NN denotes pathology
T2961 2648-2653 NN denotes lupus
T2962 2654-2658 JJ denotes like
T2963 2653-2654 HYPH denotes -
T2964 2673-2676 DT denotes the
T2965 2720-2726 NN denotes strain
T2966 2677-2680 NNP denotes New
T2967 2681-2688 NNP denotes Zealand
T2968 2689-2694 NN denotes Black
T2969 2694-2695 HYPH denotes /
T2970 2695-2698 NNP denotes New
T2971 2699-2706 NNP denotes Zealand
T2972 2707-2712 NN denotes White
T2973 2713-2719 NN denotes hybrid
T2974 2727-2728 -LRB- denotes (
T2975 2732-2735 NN denotes WF1
T2976 2728-2731 NN denotes NZB
T2977 2731-2732 HYPH denotes /
T2978 2735-2736 -RRB- denotes )
T2979 2736-2737 : denotes ;
T2980 2738-2741 DT denotes the
T2981 2757-2763 NN denotes strain
T2982 2742-2745 NN denotes MRL
T2983 2746-2748 NN denotes Mp
T2984 2745-2746 HYPH denotes /
T2985 2749-2752 NN denotes lpr
T2986 2753-2756 NN denotes lpr
T2987 2752-2753 HYPH denotes /
T2988 2763-2765 , denotes ,
T2989 2765-2770 WDT denotes which
T2990 2771-2778 VBZ denotes carries
T2991 2779-2782 DT denotes the
T2992 2787-2795 NN denotes mutation
T2993 2783-2786 NN denotes lpr
T2994 2796-2798 IN denotes of
T2995 2799-2802 DT denotes the
T2996 2816-2820 NN denotes gene
T2997 2803-2806 NN denotes FAS
T2998 2807-2815 NN denotes receptor
T2999 2820-2821 : denotes ;
T3000 2822-2825 CC denotes and
T3001 2826-2829 DT denotes the
T3002 2835-2841 NN denotes strain
T3003 2830-2834 NN denotes BXSB
T3004 2841-2843 , denotes ,
T3005 2843-2848 WDT denotes which
T3265 4378-4711 sentence denotes In this regard, it is of note that hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, are spontaneously predisposed to development of humoral autoimmunity with low levels of glomerulonephritis (Obata et al. 1979; Botto et al. 1998; Bickerstaff et al. 1999; Santiago-Raber et al. 2001).
T3266 4379-4381 IN denotes In
T3006 2849-2856 VBZ denotes carries
T3007 2857-2860 DT denotes the
T3267 4398-4400 VBZ denotes is
T3268 4382-4386 DT denotes this
T3269 4387-4393 NN denotes regard
T3008 2903-2907 NN denotes gene
T3270 4393-4395 , denotes ,
T3009 2861-2862 NN denotes Y
T3271 4395-4397 PRP denotes it
T3010 2863-2873 NN denotes chromosome
T3121 3556-3564 JJ denotes striking
T3272 4401-4403 IN denotes of
T3273 4404-4408 NN denotes note
T3274 4409-4413 IN denotes that
T3011 2885-2896 NN denotes accelerator
T3122 3551-3555 RBS denotes most
T3012 2874-2884 JJ denotes autoimmune
T3275 4512-4515 VBP denotes are
T3123 3569-3573 NNS denotes loci
T3124 3574-3576 IN denotes on
T3276 4414-4420 JJ denotes hybrid
T3277 4421-4428 NNS denotes strains
T3278 4429-4436 IN denotes between
T3125 3577-3583 JJ denotes distal
T3013 2897-2898 -LRB- denotes (
T3014 2898-2901 NNP denotes Yaa
T3126 3584-3594 NN denotes Chromosome
T3127 3595-3596 CD denotes 1
T3015 2901-2902 -RRB- denotes )
T3128 3596-3598 , denotes ,
T3016 2908-2909 -LRB- denotes (
T3279 4437-4440 CD denotes 129
T3017 2909-2923 NNP denotes Theofilopoulos
T3129 3598-3601 IN denotes for
T3280 4453-4457 NNS denotes mice
T3117 3519-3525 VBN denotes shared
T3118 3526-3540 NN denotes susceptibility
T3018 2924-2927 CC denotes and
T3281 4441-4444 CC denotes and
T3282 4445-4450 NN denotes C57BL
T3019 2928-2933 NNP denotes Dixon
T3119 3545-3547 , denotes ,
T3020 2934-2938 CD denotes 1985
T3120 3547-3550 DT denotes the
T3021 2938-2939 -RRB- denotes )
T3022 2939-2940 . denotes .
T3023 2940-3070 sentence denotes Extensive genetic mapping studies in all three strains have identified multiple intervals associated with disease susceptibility.
T3024 2941-2950 JJ denotes Extensive
T3025 2967-2974 NNS denotes studies
T3026 2951-2958 JJ denotes genetic
T3027 2959-2966 NN denotes mapping
T3028 3001-3011 VBN denotes identified
T3029 2975-2977 IN denotes in
T3030 2978-2981 DT denotes all
T3031 2988-2995 NNS denotes strains
T3032 2982-2987 CD denotes three
T3033 2996-3000 VBP denotes have
T3034 3012-3020 JJ denotes multiple
T3035 3021-3030 NNS denotes intervals
T3036 3031-3041 VBN denotes associated
T3037 3042-3046 IN denotes with
T3038 3047-3054 NN denotes disease
T3039 3055-3069 NN denotes susceptibility
T3040 3069-3070 . denotes .
T3041 3070-3311 sentence denotes Interestingly, the majority of the intervals detected are strain-specific, confirming the genetic complexity of the disease and indicating the presence of extensive heterogeneity in the genes contributing to the pathogenesis of the disease.
T3042 3071-3084 RB denotes Interestingly
T3043 3125-3128 VBP denotes are
T3044 3084-3086 , denotes ,
T3045 3086-3089 DT denotes the
T3046 3090-3098 NN denotes majority
T3047 3099-3101 IN denotes of
T3048 3102-3105 DT denotes the
T3049 3106-3115 NNS denotes intervals
T3050 3116-3124 VBN denotes detected
T3051 3129-3135 NN denotes strain
T3052 3136-3144 JJ denotes specific
T3053 3135-3136 HYPH denotes -
T3054 3144-3146 , denotes ,
T3055 3146-3156 VBG denotes confirming
T3056 3157-3160 DT denotes the
T3057 3169-3179 NN denotes complexity
T3058 3161-3168 JJ denotes genetic
T3059 3180-3182 IN denotes of
T3060 3183-3186 DT denotes the
T3061 3187-3194 NN denotes disease
T3062 3195-3198 CC denotes and
T3063 3199-3209 VBG denotes indicating
T3064 3210-3213 DT denotes the
T3065 3214-3222 NN denotes presence
T3066 3223-3225 IN denotes of
T3067 3226-3235 JJ denotes extensive
T3068 3236-3249 NN denotes heterogeneity
T3069 3250-3252 IN denotes in
T3073 3276-3278 IN denotes to
T3074 3279-3282 DT denotes the
T3075 3283-3295 NN denotes pathogenesis
T3076 3296-3298 IN denotes of
T3077 3299-3302 DT denotes the
T3078 3303-3310 NN denotes disease
T3079 3310-3311 . denotes .
T3080 3311-3504 sentence denotes However, some susceptibility loci have been mapped to similar chromosome locations in different strains, suggesting that at least some susceptibility may be shared amongst lupus-prone strains.
T3081 3312-3319 RB denotes However
T3082 3356-3362 VBN denotes mapped
T3083 3319-3321 , denotes ,
T3084 3321-3325 DT denotes some
T3085 3341-3345 NNS denotes loci
T3086 3326-3340 NN denotes susceptibility
T3087 3346-3350 VBP denotes have
T3088 3351-3355 VBN denotes been
T3089 3363-3365 IN denotes to
T3090 3366-3373 JJ denotes similar
T3091 3385-3394 NNS denotes locations
T3092 3374-3384 NN denotes chromosome
T3093 3395-3397 IN denotes in
T3094 3398-3407 JJ denotes different
T3095 3408-3415 NNS denotes strains
T3096 3415-3417 , denotes ,
T3097 3417-3427 VBG denotes suggesting
T3098 3428-3432 IN denotes that
T3099 3469-3475 VBN denotes shared
T3100 3433-3435 RB denotes at
T3101 3436-3441 RBS denotes least
T3102 3447-3461 NN denotes susceptibility
T3103 3442-3446 DT denotes some
T3104 3462-3465 MD denotes may
T3105 3466-3468 VB denotes be
T3106 3476-3483 IN denotes amongst
T3107 3484-3489 NN denotes lupus
T3108 3490-3495 JJ denotes prone
T3109 3489-3490 HYPH denotes -
T3110 3496-3503 NNS denotes strains
T3111 3503-3504 . denotes .
T3112 3504-3737 sentence denotes Amongst these shared susceptibility loci, the most striking are loci on distal Chromosome 1, for which important contributing genes have been found in New Zealand and BXSB models (Theofilopoulos and Kono 1999; Wakeland et al. 2001).
T3113 3505-3512 IN denotes Amongst
T3114 3565-3568 VBP denotes are
T3115 3513-3518 DT denotes these
T3116 3541-3545 NNS denotes loci
T3130 3647-3652 VBN denotes found
T3131 3602-3607 WDT denotes which
T3132 3608-3617 JJ denotes important
T3133 3631-3636 NNS denotes genes
T3134 3618-3630 VBG denotes contributing
T3135 3637-3641 VBP denotes have
T3136 3642-3646 VBN denotes been
T3137 3653-3655 IN denotes in
T3138 3656-3659 NNP denotes New
T3139 3660-3667 NNP denotes Zealand
T3140 3677-3683 NNS denotes models
T3141 3668-3671 CC denotes and
T3142 3672-3676 NN denotes BXSB
T3143 3684-3685 -LRB- denotes (
T3144 3685-3699 NNP denotes Theofilopoulos
T3145 3700-3703 CC denotes and
T3146 3704-3708 NNP denotes Kono
T3147 3709-3713 CD denotes 1999
T3148 3713-3714 : denotes ;
T3149 3715-3723 NNP denotes Wakeland
T3150 3724-3726 FW denotes et
T3151 3727-3730 FW denotes al.
T3152 3731-3735 CD denotes 2001
T3153 3735-3736 -RRB- denotes )
T3154 3736-3737 . denotes .
T3155 3737-4049 sentence denotes Although considerable efforts have been made to identify the genes responsible for the development of the disease, with the exception of the lpr mutation, none of the genetic contributions to disease in the three well-documented murine SLE strains have yet been fully resolved at the molecular or protein level.
T3156 3738-3746 IN denotes Although
T3157 3778-3782 VBN denotes made
T3158 3747-3759 JJ denotes considerable
T3159 3760-3767 NNS denotes efforts
T3160 3768-3772 VBP denotes have
T3161 3773-3777 VBN denotes been
T3162 4006-4014 VBN denotes resolved
T3163 3783-3785 TO denotes to
T3164 3786-3794 VB denotes identify
T3165 3795-3798 DT denotes the
T3166 3799-3804 NNS denotes genes
T3167 3805-3816 JJ denotes responsible
T3168 3817-3820 IN denotes for
T3169 3821-3824 DT denotes the
T3170 3825-3836 NN denotes development
T3171 3837-3839 IN denotes of
T3172 3840-3843 DT denotes the
T3173 3844-3851 NN denotes disease
T3174 3851-3853 , denotes ,
T3175 3853-3857 IN denotes with
T3176 3858-3861 DT denotes the
T3177 3862-3871 NN denotes exception
T3178 3872-3874 IN denotes of
T3179 3875-3878 DT denotes the
T3180 3883-3891 NN denotes mutation
T3181 3879-3882 NN denotes lpr
T3182 3891-3893 , denotes ,
T3183 3893-3897 NN denotes none
T3184 3898-3900 IN denotes of
T3185 3901-3904 DT denotes the
T3186 3913-3926 NNS denotes contributions
T3187 3905-3912 JJ denotes genetic
T3188 3927-3929 IN denotes to
T3189 3930-3937 NN denotes disease
T3190 3938-3940 IN denotes in
T3191 3941-3944 DT denotes the
T3192 3978-3985 NNS denotes strains
T3193 3945-3950 CD denotes three
T3194 3951-3955 RB denotes well
T3195 3956-3966 VBN denotes documented
T3196 3955-3956 HYPH denotes -
T3197 3967-3973 JJ denotes murine
T3198 3974-3977 NN denotes SLE
T3199 3986-3990 VBP denotes have
T3200 3991-3994 RB denotes yet
T3201 3995-3999 VBN denotes been
T3202 4000-4005 RB denotes fully
T3203 4015-4017 IN denotes at
T3204 4018-4021 DT denotes the
T3205 4043-4048 NN denotes level
T3206 4022-4031 JJ denotes molecular
T3207 4035-4042 NN denotes protein
T3208 4032-4034 CC denotes or
T3209 4048-4049 . denotes .
T3210 4049-4211 sentence denotes Thus, targeted genetic disruption of candidate genes encoding proteins of the immune system has been extensively used to examine their role in immune regulation.
T3211 4050-4054 RB denotes Thus
T3212 4163-4167 VBN denotes used
T3213 4054-4056 , denotes ,
T3214 4056-4064 VBN denotes targeted
T3215 4073-4083 NN denotes disruption
T3216 4065-4072 JJ denotes genetic
T3217 4084-4086 IN denotes of
T3218 4087-4096 NN denotes candidate
T3219 4097-4102 NNS denotes genes
T3220 4103-4111 VBG denotes encoding
T3221 4112-4120 NN denotes proteins
T3222 4121-4123 IN denotes of
T3223 4124-4127 DT denotes the
T3252 4287-4291 JJ denotes high
T3283 4450-4451 HYPH denotes /
T3224 4135-4141 NN denotes system
T3225 4128-4134 JJ denotes immune
T3226 4142-4145 VBZ denotes has
T3227 4146-4150 VBN denotes been
T3228 4151-4162 RB denotes extensively
T3229 4168-4170 TO denotes to
T3230 4171-4178 VB denotes examine
T3231 4179-4184 PRP$ denotes their
T3232 4185-4189 NN denotes role
T3233 4190-4192 IN denotes in
T3234 4193-4199 JJ denotes immune
T3235 4200-4210 NN denotes regulation
T3236 4210-4211 . denotes .
T3237 4211-4378 sentence denotes However, the most surprising result of this powerful approach has been the high frequency with which such mutations have been associated with an autoimmune phenotype.
T3238 4212-4219 RB denotes However
T3239 4278-4282 VBN denotes been
T3240 4219-4221 , denotes ,
T3241 4221-4224 DT denotes the
T3242 4241-4247 NN denotes result
T3243 4225-4229 RBS denotes most
T3244 4230-4240 JJ denotes surprising
T3245 4248-4250 IN denotes of
T3246 4251-4255 DT denotes this
T3247 4265-4273 NN denotes approach
T3248 4256-4264 JJ denotes powerful
T3249 4274-4277 VBZ denotes has
T3250 4283-4286 DT denotes the
T3251 4292-4301 NN denotes frequency
T3284 4451-4452 CD denotes 6
T3285 4457-4459 , denotes ,
T3286 4459-4465 RB denotes widely
T3287 4466-4470 VBN denotes used
T3288 4471-4473 IN denotes in
T3289 4474-4477 DT denotes the
T3290 4478-4488 NN denotes generation
T3291 4489-4491 IN denotes of
T3292 4492-4496 NN denotes gene
T3293 4497-4505 VBN denotes targeted
T3294 4496-4497 HYPH denotes -
T3295 4506-4510 NNS denotes mice
T3296 4510-4512 , denotes ,
T3297 4516-4529 RB denotes spontaneously
T3298 4530-4541 VBN denotes predisposed
T3299 4542-4544 IN denotes to
T3300 4545-4556 NN denotes development
T3301 4557-4559 IN denotes of
T3302 4560-4567 JJ denotes humoral
T3303 4568-4580 NN denotes autoimmunity
T3304 4581-4585 IN denotes with
T3305 4586-4589 JJ denotes low
T3306 4590-4596 NNS denotes levels
T3307 4597-4599 IN denotes of
T3308 4600-4618 NN denotes glomerulonephritis
T3309 4619-4620 -LRB- denotes (
T3310 4620-4625 NNP denotes Obata
T3311 4626-4628 FW denotes et
T3312 4629-4632 FW denotes al.
T3313 4633-4637 CD denotes 1979
T3314 4637-4638 : denotes ;
T3315 4639-4644 NNP denotes Botto
T3316 4645-4647 FW denotes et
T3317 4648-4651 FW denotes al.
T3318 4652-4656 CD denotes 1998
T3319 4656-4657 : denotes ;
T3320 4658-4669 NNP denotes Bickerstaff
T3321 4670-4672 FW denotes et
T3322 4673-4676 FW denotes al.
T3323 4677-4681 CD denotes 1999
T3324 4681-4682 : denotes ;
T3325 4683-4691 NNP denotes Santiago
T3326 4691-4692 HYPH denotes -
T3327 4692-4697 NNP denotes Raber
T3328 4698-4700 FW denotes et
T3329 4701-4704 FW denotes al.
T3330 4705-4709 CD denotes 2001
T3331 4709-4710 -RRB- denotes )
T3332 4710-4711 . denotes .
T3333 4711-4892 sentence denotes Furthermore, the genetic background markedly influences the autoimmune phenotype in gene-targeted mice (Bolland and Ravetch 2000; Santiago-Raber et al. 2001; Mitchell et al. 2002).
T3334 4712-4723 RB denotes Furthermore
T3335 4757-4767 VBZ denotes influences
T3336 4723-4725 , denotes ,
T3337 4725-4728 DT denotes the
T3338 4737-4747 NN denotes background
T3339 4729-4736 JJ denotes genetic
T3340 4748-4756 RB denotes markedly
T3341 4768-4771 DT denotes the
T3342 4783-4792 NN denotes phenotype
T3343 4772-4782 JJ denotes autoimmune
T3344 4793-4795 IN denotes in
T3345 4796-4800 NN denotes gene
T3346 4801-4809 VBN denotes targeted
T3347 4800-4801 HYPH denotes -
T3348 4810-4814 NNS denotes mice
T3349 4815-4816 -LRB- denotes (
T3350 4816-4823 NNP denotes Bolland
T3351 4824-4827 CC denotes and
T3352 4828-4835 NNP denotes Ravetch
T3353 4836-4840 CD denotes 2000
T3354 4840-4841 : denotes ;
T3355 4842-4850 NNP denotes Santiago
T3356 4850-4851 HYPH denotes -
T3357 4851-4856 NNP denotes Raber
T3358 4857-4859 FW denotes et
T3359 4860-4863 FW denotes al.
T3360 4864-4868 CD denotes 2001
T3361 4868-4869 : denotes ;
T3362 4870-4878 NNP denotes Mitchell
T3363 4879-4881 FW denotes et
T3364 4882-4885 FW denotes al.
T3365 4886-4890 CD denotes 2002
T3366 4890-4891 -RRB- denotes )
T3367 4891-4892 . denotes .
T3368 4892-5174 sentence denotes These observations led to the hypothesis that the autoimmune phenotype described in some gene-targeted mice might be due primarily to combinations of as-yet-uncharacterised background genes, originating from 129 and C57BL/6 mice strains, interacting or not with the mutated allele.
T3369 4893-4898 DT denotes These
T3370 4899-4911 NNS denotes observations
T3371 4912-4915 VBD denotes led
T3372 4916-4918 IN denotes to
T3373 4919-4922 DT denotes the
T3374 4923-4933 NN denotes hypothesis
T3375 4934-4938 IN denotes that
T3376 5007-5009 VB denotes be
T3377 4939-4942 DT denotes the
T3378 4954-4963 NN denotes phenotype
T3379 4943-4953 JJ denotes autoimmune
T3380 4964-4973 VBN denotes described
T3381 4974-4976 IN denotes in
T3382 4977-4981 DT denotes some
T3383 4996-5000 NNS denotes mice
T3384 4982-4986 NN denotes gene
T3385 4987-4995 VBN denotes targeted
T3386 4986-4987 HYPH denotes -
T3387 5001-5006 MD denotes might
T3388 5010-5013 IN denotes due
T3389 5014-5023 RB denotes primarily
T3390 5024-5026 IN denotes to
T3391 5027-5039 NNS denotes combinations
T3392 5040-5042 IN denotes of
T3393 5043-5045 RB denotes as
T3394 5046-5049 RB denotes yet
T3395 5045-5046 HYPH denotes -
T3396 5050-5065 JJ denotes uncharacterised
T3397 5049-5050 HYPH denotes -
T3398 5077-5082 NNS denotes genes
T3399 5066-5076 NN denotes background
T3400 5082-5084 , denotes ,
T3401 5084-5095 VBG denotes originating
T3402 5096-5100 IN denotes from
T3403 5101-5104 CD denotes 129
T3404 5122-5129 NNS denotes strains
T3405 5105-5108 CC denotes and
T3406 5109-5114 NN denotes C57BL
T3407 5114-5115 HYPH denotes /
T3408 5115-5116 CD denotes 6
T3409 5117-5121 NNS denotes mice
T3410 5129-5131 , denotes ,
T3411 5131-5142 VBG denotes interacting
T3412 5143-5145 CC denotes or
T3413 5146-5149 RB denotes not
T3414 5150-5154 IN denotes with
T3415 5155-5158 DT denotes the
T3416 5167-5173 NN denotes allele
T3417 5159-5166 VBN denotes mutated
T3418 5173-5174 . denotes .
T3419 5174-5355 sentence denotes To test this, we conducted a genome-wide scan analysis of two large cohorts of (129 × C57BL/6)F2 mice, one of which carried a mutation in the serum amyloid P component gene (Apcs).
T3420 5175-5177 TO denotes To
T3421 5178-5182 VB denotes test
T3422 5192-5201 VBD denotes conducted
T3423 5183-5187 DT denotes this
T3424 5187-5189 , denotes ,
T3425 5189-5191 PRP denotes we
T3426 5202-5203 DT denotes a
T3427 5221-5229 NN denotes analysis
T3428 5204-5210 NN denotes genome
T3429 5211-5215 JJ denotes wide
T3430 5210-5211 HYPH denotes -
T3431 5216-5220 NN denotes scan
T3432 5230-5232 IN denotes of
T3433 5233-5236 CD denotes two
T3434 5243-5250 NNS denotes cohorts
T3435 5237-5242 JJ denotes large
T3436 5251-5253 IN denotes of
T3437 5254-5255 -LRB- denotes (
T3438 5272-5276 NNS denotes mice
T3439 5255-5258 CD denotes 129
T3440 5259-5260 SYM denotes ×
T3441 5261-5266 NN denotes C57BL
T3442 5266-5267 HYPH denotes /
T3443 5267-5268 CD denotes 6
T3444 5268-5269 -RRB- denotes )
T3445 5269-5271 NN denotes F2
T3446 5276-5278 , denotes ,
T3447 5278-5281 CD denotes one
T3448 5291-5298 VBD denotes carried
T3449 5282-5284 IN denotes of
T3450 5285-5290 WDT denotes which
T3451 5299-5300 DT denotes a
T3452 5301-5309 NN denotes mutation
T3453 5310-5312 IN denotes in
T3454 5313-5316 DT denotes the
T3455 5343-5347 NN denotes gene
T3456 5317-5322 NN denotes serum
T3457 5333-5342 NN denotes component
T3458 5323-5330 NN denotes amyloid
T3459 5331-5332 NN denotes P
T3460 5348-5349 -LRB- denotes (
T3461 5349-5353 NN denotes Apcs
T3462 5353-5354 -RRB- denotes )
T3463 5354-5355 . denotes .
T3464 5355-5664 sentence denotes The Apcs-deficient mice (Apcs −/−) were chosen as an example of a gene-targeted strain previously reported to develop a lupus-like disease on the hybrid genetic background (129 × C57BL/6); autoimmunity in Apcs −/− mice persists even after backcrossing the mutated gene onto C57BL/6 (Bickerstaff et al. 1999).
T3465 5356-5359 DT denotes The
T3466 5375-5379 NNS denotes mice
T3467 5360-5364 NN denotes Apcs
T3468 5365-5374 JJ denotes deficient
T3469 5364-5365 HYPH denotes -
T3470 5396-5402 VBN denotes chosen
T3471 5380-5381 -LRB- denotes (
T3472 5381-5385 NN denotes Apcs
T3473 5386-5387 SYM denotes −
T3474 5387-5388 HYPH denotes /
T3475 5388-5389 SYM denotes −
T3476 5389-5390 -RRB- denotes )
T3477 5391-5395 VBD denotes were
T3478 5575-5583 VBZ denotes persists
T3479 5403-5405 IN denotes as
T3480 5406-5408 DT denotes an
T3481 5409-5416 NN denotes example
T3482 5417-5419 IN denotes of
T3483 5420-5421 DT denotes a
T3484 5436-5442 NN denotes strain
T3485 5422-5426 NN denotes gene
T3486 5427-5435 VBN denotes targeted
T3487 5426-5427 HYPH denotes -
T3488 5443-5453 RB denotes previously
T3489 5454-5462 VBN denotes reported
T3490 5463-5465 TO denotes to
T3491 5466-5473 VB denotes develop
T3492 5474-5475 DT denotes a
T3493 5487-5494 NN denotes disease
T3494 5476-5481 NN denotes lupus
T3495 5482-5486 JJ denotes like
T3496 5481-5482 HYPH denotes -
T3497 5495-5497 IN denotes on
T3498 5498-5501 DT denotes the
T3499 5535-5540 NN denotes C57BL
T3500 5502-5508 NN denotes hybrid
T3501 5509-5516 JJ denotes genetic
T3502 5517-5527 NN denotes background
T3503 5528-5529 -LRB- denotes (
T3504 5529-5532 CD denotes 129
T3505 5533-5534 SYM denotes ×
T3506 5540-5541 HYPH denotes /
T3507 5541-5542 CD denotes 6
T3508 5542-5543 -RRB- denotes )
T3509 5543-5544 : denotes ;
T3510 5545-5557 NN denotes autoimmunity
T3511 5558-5560 IN denotes in
T3512 5561-5565 NN denotes Apcs
T3513 5570-5574 NNS denotes mice
T3514 5566-5567 SYM denotes −
T3515 5567-5568 HYPH denotes /
T3516 5568-5569 SYM denotes −
T3517 5584-5588 RB denotes even
T3518 5589-5594 IN denotes after
T3519 5595-5607 VBG denotes backcrossing
T3520 5608-5611 DT denotes the
T3521 5620-5624 NN denotes gene
T3522 5612-5619 VBN denotes mutated
T3523 5625-5629 IN denotes onto
T3524 5630-5635 NN denotes C57BL
T3525 5635-5636 HYPH denotes /
T3526 5636-5637 CD denotes 6
T3527 5638-5639 -LRB- denotes (
T3528 5639-5650 NNP denotes Bickerstaff
T3529 5651-5653 FW denotes et
T3530 5654-5657 FW denotes al.
T3531 5658-5662 CD denotes 1999
T3532 5662-5663 -RRB- denotes )
T3533 5663-5664 . denotes .
T3534 5664-6069 sentence denotes We chose this targeted gene in particular to study since the Apcs gene is located on Chromosome 1, approximately 94 cM from the centromere, within a region where several lupus-susceptibility loci, designated Sle1 (Morel et al. 2001), Nba2 (Drake et al. 1995; Vyse et al. 1997), and Bxs3 (Hogarth et al. 1998; Haywood et al. 2000), have been mapped in NZW, NZB, and BXSB lupus-prone strains, respectively.
T3535 5665-5667 PRP denotes We
T3536 5668-5673 VBD denotes chose
T3537 5674-5678 DT denotes this
T3538 5688-5692 NN denotes gene
T3539 5679-5687 VBN denotes targeted
T3540 5693-5695 IN denotes in
T3541 5696-5706 JJ denotes particular
T3542 5707-5709 TO denotes to
T3543 5710-5715 VB denotes study
T3544 5716-5721 IN denotes since
T3545 5739-5746 VBN denotes located
T3546 5722-5725 DT denotes the
T3547 5731-5735 NN denotes gene
T3548 5726-5730 NN denotes Apcs
T3549 5736-5738 VBZ denotes is
T3550 5747-5749 IN denotes on
T3551 5750-5760 NN denotes Chromosome
T3552 5761-5762 CD denotes 1
T3553 5762-5764 , denotes ,
T3554 5764-5777 RB denotes approximately
T3555 5778-5780 CD denotes 94
T3556 5781-5783 NN denotes cM
T3557 5784-5788 IN denotes from
T3558 5789-5792 DT denotes the
T3559 5793-5803 NN denotes centromere
T3560 5803-5805 , denotes ,
T3561 5805-5811 IN denotes within
T3562 5812-5813 DT denotes a
T3563 5814-5820 NN denotes region
T3564 5821-5826 WRB denotes where
T3565 6006-6012 VBN denotes mapped
T3566 5827-5834 JJ denotes several
T3567 5856-5860 NNS denotes loci
T3568 5835-5840 NN denotes lupus
T3569 5841-5855 NN denotes susceptibility
T3570 5840-5841 HYPH denotes -
T3571 5860-5862 , denotes ,
T3572 5862-5872 VBN denotes designated
T3573 5873-5877 NN denotes Sle1
T3574 5878-5879 -LRB- denotes (
T3575 5879-5884 NNP denotes Morel
T3576 5885-5887 FW denotes et
T3577 5888-5891 FW denotes al.
T3578 5892-5896 CD denotes 2001
T3579 5896-5897 -RRB- denotes )
T3580 5897-5899 , denotes ,
T3581 5899-5903 NN denotes Nba2
T3582 5904-5905 -LRB- denotes (
T3583 5905-5910 NNP denotes Drake
T3584 5911-5913 FW denotes et
T3585 5914-5917 FW denotes al.
T3586 5918-5922 CD denotes 1995
T3587 5922-5923 : denotes ;
T3588 5924-5928 NNP denotes Vyse
T3589 5929-5931 FW denotes et
T3590 5932-5935 FW denotes al.
T3591 5936-5940 CD denotes 1997
T3592 5940-5941 -RRB- denotes )
T3593 5941-5943 , denotes ,
T3594 5943-5946 CC denotes and
T3595 5947-5951 NN denotes Bxs3
T3596 5952-5953 -LRB- denotes (
T3597 5953-5960 NNP denotes Hogarth
T3598 5961-5963 FW denotes et
T3599 5964-5967 FW denotes al.
T3600 5968-5972 CD denotes 1998
T3601 5972-5973 : denotes ;
T3602 5974-5981 NNP denotes Haywood
T3603 5982-5984 FW denotes et
T3604 5985-5988 FW denotes al.
T3605 5989-5993 CD denotes 2000
T3606 5993-5994 -RRB- denotes )
T3607 5994-5996 , denotes ,
T3608 5996-6000 VBP denotes have
T3609 6001-6005 VBN denotes been
T3610 6013-6015 IN denotes in
T3611 6016-6019 NN denotes NZW
T3612 6047-6054 NNS denotes strains
T3613 6019-6021 , denotes ,
T3614 6021-6024 NN denotes NZB
T3615 6024-6026 , denotes ,
T3616 6026-6029 CC denotes and
T3617 6030-6034 NN denotes BXSB
T3618 6035-6040 NN denotes lupus
T3619 6041-6046 JJ denotes prone
T3620 6040-6041 HYPH denotes -
T3621 6054-6056 , denotes ,
T3622 6056-6068 RB denotes respectively
T3623 6068-6069 . denotes .
T3624 6069-6423 sentence denotes This region contains several genes, including those encoding FcγRII, the complement receptor CR1/2 (CD35/CD21), and the decay-accelerating factor CD55 (Prodeus et al. 1998; Bolland and Ravetch 2000; Miwa et al. 2002; Wu et al. 2002), which have each been implicated in the causation of SLE when inactivated by gene-targeting in 129 embryonic stem cells.
T3625 6070-6074 DT denotes This
T3626 6075-6081 NN denotes region
T3627 6082-6090 VBZ denotes contains
T3628 6091-6098 JJ denotes several
T3629 6099-6104 NNS denotes genes
T3630 6104-6106 , denotes ,
T3631 6106-6115 VBG denotes including
T3632 6116-6121 DT denotes those
T3633 6122-6130 VBG denotes encoding
T3634 6131-6137 NN denotes FcγRII
T3635 6137-6139 , denotes ,
T3636 6139-6142 DT denotes the
T3637 6154-6162 NN denotes receptor
T3638 6143-6153 NN denotes complement
T3639 6163-6166 NN denotes CR1
T3640 6166-6167 HYPH denotes /
T3641 6167-6168 CD denotes 2
T3642 6169-6170 -LRB- denotes (
T3643 6170-6174 NN denotes CD35
T3644 6175-6179 NN denotes CD21
T3645 6174-6175 HYPH denotes /
T3646 6179-6180 -RRB- denotes )
T3647 6180-6182 , denotes ,
T3648 6182-6185 CC denotes and
T3649 6186-6189 DT denotes the
T3650 6216-6220 NN denotes CD55
T3651 6190-6195 NN denotes decay
T3652 6196-6208 VBG denotes accelerating
T3653 6195-6196 HYPH denotes -
T3654 6209-6215 NN denotes factor
T3655 6221-6222 -LRB- denotes (
T3656 6222-6229 NNP denotes Prodeus
T3657 6230-6232 FW denotes et
T3658 6233-6236 FW denotes al.
T3659 6237-6241 CD denotes 1998
T3660 6241-6242 : denotes ;
T3661 6243-6250 NNP denotes Bolland
T3662 6251-6254 CC denotes and
T3663 6255-6262 NNP denotes Ravetch
T3664 6263-6267 CD denotes 2000
T3665 6267-6268 : denotes ;
T3666 6269-6273 NNP denotes Miwa
T3667 6274-6276 FW denotes et
T3668 6277-6280 FW denotes al.
T3669 6281-6285 CD denotes 2002
T3670 6285-6286 : denotes ;
T3671 6287-6289 NNP denotes Wu
T3672 6290-6292 FW denotes et
T3673 6293-6296 FW denotes al.
T3674 6297-6301 CD denotes 2002
T3675 6301-6302 -RRB- denotes )
T3676 6302-6304 , denotes ,
T3677 6304-6309 WDT denotes which
T3678 6325-6335 VBN denotes implicated
T3679 6310-6314 VBP denotes have
T3680 6315-6319 DT denotes each
T3681 6320-6324 VBN denotes been
T3682 6336-6338 IN denotes in
T3683 6339-6342 DT denotes the
T3684 6343-6352 NN denotes causation
T3685 6353-6355 IN denotes of
T3686 6356-6359 NN denotes SLE
T3687 6360-6364 WRB denotes when
T3688 6365-6376 VBN denotes inactivated
T3689 6377-6379 IN denotes by
T3690 6380-6384 NN denotes gene
T3691 6384-6385 HYPH denotes -
T3692 6385-6394 VBG denotes targeting
T3693 6395-6397 IN denotes in
T3694 6398-6401 CD denotes 129
T3695 6417-6422 NNS denotes cells
T3696 6402-6411 JJ denotes embryonic
T3697 6412-6416 NN denotes stem
T3698 6422-6423 . denotes .
T3699 6423-6544 sentence denotes Here we show that there are multiple genetic loci, derived from both 129 and C57BL/6 mice, contributing to autoimmunity.
T3700 6424-6428 RB denotes Here
T3701 6432-6436 VBP denotes show
T3702 6429-6431 PRP denotes we
T3703 6437-6441 IN denotes that
T3704 6448-6451 VBP denotes are
T3705 6442-6447 EX denotes there
T3706 6452-6460 JJ denotes multiple
T3707 6469-6473 NNS denotes loci
T3708 6461-6468 JJ denotes genetic
T3709 6473-6475 , denotes ,
T3710 6475-6482 VBN denotes derived
T3711 6483-6487 IN denotes from
T3712 6488-6492 CC denotes both
T3764 6743-6746 CD denotes 129
T3713 6493-6496 CD denotes 129
T3714 6509-6513 NNS denotes mice
T3715 6497-6500 CC denotes and
T3716 6501-6506 NN denotes C57BL
T3717 6506-6507 HYPH denotes /
T3718 6507-6508 CD denotes 6
T3719 6513-6515 , denotes ,
T3720 6515-6527 VBG denotes contributing
T3721 6528-6530 IN denotes to
T3722 6531-6543 NN denotes autoimmunity
T3723 6543-6544 . denotes .
T3724 6544-6886 sentence denotes Furthermore, a 129-derived interval on distal Chromosome 1, when transferred onto the C57BL/6 genome, a combination commonly created by backcrossing onto C57BL/6 a gene that has been inactivated in 129 embryonic stem cells, was sufficient to cause humoral autoimmunity in its own right, irrespective of the presence of the mutated Apcs gene.
T3725 6545-6556 RB denotes Furthermore
T3726 6769-6772 VBD denotes was
T3727 6556-6558 , denotes ,
T3728 6558-6559 DT denotes a
T3729 6572-6580 NN denotes interval
T3730 6560-6563 CD denotes 129
T3731 6564-6571 VBN denotes derived
T3732 6563-6564 HYPH denotes -
T3733 6581-6583 IN denotes on
T3734 6584-6590 JJ denotes distal
T3735 6591-6601 NN denotes Chromosome
T3736 6602-6603 CD denotes 1
T3737 6603-6605 , denotes ,
T3738 6605-6609 WRB denotes when
T3739 6610-6621 VBN denotes transferred
T3740 6622-6626 IN denotes onto
T3741 6627-6630 DT denotes the
T3742 6639-6645 NN denotes genome
T3743 6631-6636 NN denotes C57BL
T3744 6636-6637 HYPH denotes /
T3745 6637-6638 CD denotes 6
T3746 6645-6647 , denotes ,
T3747 6647-6648 DT denotes a
T3748 6649-6660 NN denotes combination
T3749 6661-6669 RB denotes commonly
T3750 6670-6677 VBN denotes created
T3751 6678-6680 IN denotes by
T3752 6681-6693 VBG denotes backcrossing
T3753 6694-6698 IN denotes onto
T3754 6699-6704 NN denotes C57BL
T3755 6704-6705 HYPH denotes /
T3756 6705-6706 CD denotes 6
T3757 6707-6708 DT denotes a
T3758 6709-6713 NN denotes gene
T3759 6714-6718 WDT denotes that
T3760 6728-6739 VBN denotes inactivated
T3761 6719-6722 VBZ denotes has
T3762 6723-6727 VBN denotes been
T3763 6740-6742 IN denotes in
T3765 6762-6767 NNS denotes cells
T3766 6747-6756 JJ denotes embryonic
T3767 6757-6761 NN denotes stem
T3768 6767-6769 , denotes ,
T3769 6773-6783 JJ denotes sufficient
T3770 6784-6786 TO denotes to
T3771 6787-6792 VB denotes cause
T3772 6793-6800 JJ denotes humoral
T3773 6801-6813 NN denotes autoimmunity
T3774 6814-6816 IN denotes in
T3775 6817-6820 PRP$ denotes its
T3776 6825-6830 NN denotes right
T3777 6821-6824 JJ denotes own
T3778 6830-6832 , denotes ,
T3779 6832-6844 RB denotes irrespective
T3780 6845-6847 IN denotes of
T3781 6848-6851 DT denotes the
T3782 6852-6860 NN denotes presence
T3783 6861-6863 IN denotes of
T3784 6864-6867 DT denotes the
T3785 6881-6885 NN denotes gene
T3786 6868-6875 VBN denotes mutated
T3787 6876-6880 NN denotes Apcs
T3788 6885-6886 . denotes .
T3789 6886-7186 sentence denotes These results demonstrate important epistatic interactions between genes from 129 and C57BL/6 genomes on the development of autoimmunity and illustrate the important effects of background genes in the analysis and interpretation of autoimmune phenotypes associated with targeted genetic disruptions.
T3790 6887-6892 DT denotes These
T3791 6893-6900 NNS denotes results
T3792 6901-6912 VBP denotes demonstrate
T3793 6913-6922 JJ denotes important
T3794 6933-6945 NNS denotes interactions
T3795 6923-6932 JJ denotes epistatic
T3796 6946-6953 IN denotes between
T3797 6954-6959 NNS denotes genes
T3798 6960-6964 IN denotes from
T3799 6965-6968 CD denotes 129
T3800 6981-6988 NNS denotes genomes
T3801 6969-6972 CC denotes and
T3802 6973-6978 NN denotes C57BL
T3803 6978-6979 HYPH denotes /
T3804 6979-6980 CD denotes 6
T3805 6989-6991 IN denotes on
T3806 6992-6995 DT denotes the
T3807 6996-7007 NN denotes development
T3808 7008-7010 IN denotes of
T3809 7011-7023 NN denotes autoimmunity
T3810 7024-7027 CC denotes and
T3811 7028-7038 VBP denotes illustrate
T3812 7039-7042 DT denotes the
T3813 7053-7060 NNS denotes effects
T3814 7043-7052 JJ denotes important
T3815 7061-7063 IN denotes of
T3816 7064-7074 NN denotes background
T3817 7075-7080 NNS denotes genes
T3818 7081-7083 IN denotes in
T3819 7084-7087 DT denotes the
T3820 7088-7096 NN denotes analysis
T3821 7097-7100 CC denotes and
T3822 7101-7115 NN denotes interpretation
T3823 7116-7118 IN denotes of
T3824 7119-7129 JJ denotes autoimmune
T3825 7130-7140 NNS denotes phenotypes
T3826 7141-7151 VBN denotes associated
T3827 7152-7156 IN denotes with
T3828 7157-7165 VBN denotes targeted
T3829 7174-7185 NNS denotes disruptions
T3830 7166-7173 JJ denotes genetic
T3831 7185-7186 . denotes .
T4464 7197-7204 NN denotes Disease
T4465 7205-7211 NNS denotes Traits
T4466 7212-7214 IN denotes in
T4467 7215-7216 -LRB- denotes (
T4468 7264-7268 NNS denotes Mice
T4469 7216-7219 CD denotes 129
T4470 7230-7232 NN denotes F2
T4471 7220-7221 SYM denotes ×
T4472 7222-7227 NN denotes C57BL
T4473 7227-7228 HYPH denotes /
T4474 7228-7229 CD denotes 6
T4475 7229-7230 -RRB- denotes )
T4476 7233-7236 CC denotes and
T4477 7237-7238 -LRB- denotes (
T4478 7252-7254 NN denotes F2
T4479 7238-7241 CD denotes 129
T4480 7242-7243 SYM denotes ×
T4481 7244-7249 NN denotes C57BL
T4482 7249-7250 HYPH denotes /
T4483 7250-7251 CD denotes 6
T4484 7251-7252 -RRB- denotes )
T4485 7254-7255 HYPH denotes .
T4486 7255-7259 NN denotes Apcs
T4487 7260-7261 SYM denotes −
T4488 7261-7262 HYPH denotes /
T4489 7262-7263 SYM denotes −
T4490 7268-7544 sentence denotes To investigate the genetic basis of the lupus-like disease observed in the (129 × C57BL/6) hybrid mice, we generated two large cohorts of (129 × C57BL/6)F2 animals, one carrying a mutation in the Apcs gene, and monitored them for 1 y under identical environmental conditions.
T4491 7269-7271 TO denotes To
T4492 7272-7283 VB denotes investigate
T4493 7376-7385 VBD denotes generated
T4494 7284-7287 DT denotes the
T4495 7296-7301 NN denotes basis
T4496 7288-7295 JJ denotes genetic
T4497 7302-7304 IN denotes of
T4498 7305-7308 DT denotes the
T4499 7320-7327 NN denotes disease
T4500 7309-7314 NN denotes lupus
T4501 7315-7319 JJ denotes like
T4502 7314-7315 HYPH denotes -
T4503 7328-7336 VBN denotes observed
T4504 7337-7339 IN denotes in
T4505 7340-7343 DT denotes the
T4506 7367-7371 NNS denotes mice
T4507 7344-7345 -LRB- denotes (
T4508 7345-7348 CD denotes 129
T4509 7349-7350 SYM denotes ×
T4510 7351-7356 NN denotes C57BL
T4511 7356-7357 HYPH denotes /
T4512 7357-7358 CD denotes 6
T4513 7358-7359 -RRB- denotes )
T4514 7360-7366 NN denotes hybrid
T4515 7371-7373 , denotes ,
T4516 7373-7375 PRP denotes we
T4517 7386-7389 CD denotes two
T4518 7396-7403 NNS denotes cohorts
T4519 7390-7395 JJ denotes large
T4520 7404-7406 IN denotes of
T4521 7407-7408 -LRB- denotes (
T4522 7422-7424 NN denotes F2
T4523 7408-7411 CD denotes 129
T4524 7412-7413 SYM denotes ×
T4525 7414-7419 NN denotes C57BL
T4526 7419-7420 HYPH denotes /
T4527 7420-7421 CD denotes 6
T4528 7421-7422 -RRB- denotes )
T4529 7425-7432 NNS denotes animals
T4530 7432-7434 , denotes ,
T4531 7434-7437 CD denotes one
T4532 7438-7446 VBG denotes carrying
T4533 7447-7448 DT denotes a
T4534 7449-7457 NN denotes mutation
T4535 7458-7460 IN denotes in
T4536 7461-7464 DT denotes the
T4537 7470-7474 NN denotes gene
T4538 7465-7469 NN denotes Apcs
T4539 7474-7476 , denotes ,
T4540 7476-7479 CC denotes and
T4541 7480-7489 VBD denotes monitored
T4542 7490-7494 PRP denotes them
T4543 7495-7498 IN denotes for
T4544 7499-7500 CD denotes 1
T4545 7501-7502 NN denotes y
T4546 7503-7508 IN denotes under
T4547 7509-7518 JJ denotes identical
T4548 7533-7543 NNS denotes conditions
T4549 7519-7532 JJ denotes environmental
T4550 7543-7544 . denotes .
T4551 7544-7678 sentence denotes Since female mice in the original reports showed a higher penetrance of disease, the present study was conducted only on female mice.
T4552 7545-7550 IN denotes Since
T4553 7587-7593 VBD denotes showed
T4554 7551-7557 JJ denotes female
T4555 7558-7562 NNS denotes mice
T4556 7563-7565 IN denotes in
T4557 7566-7569 DT denotes the
T4558 7579-7586 NNS denotes reports
T4559 7570-7578 JJ denotes original
T4560 7648-7657 VBN denotes conducted
T4561 7594-7595 DT denotes a
T4562 7603-7613 NN denotes penetrance
T4563 7596-7602 JJR denotes higher
T4564 7614-7616 IN denotes of
T4565 7617-7624 NN denotes disease
T4566 7624-7626 , denotes ,
T4567 7626-7629 DT denotes the
T4568 7638-7643 NN denotes study
T4569 7630-7637 JJ denotes present
T4570 7644-7647 VBD denotes was
T4571 7658-7662 RB denotes only
T4572 7663-7665 IN denotes on
T4573 7666-7672 JJ denotes female
T4574 7673-7677 NNS denotes mice
T4575 7677-7678 . denotes .
T4576 7678-7765 sentence denotes The results of the phenotypic analysis at 1 y of age are summarised in Tables 1 and 2.
T4577 7679-7682 DT denotes The
T4578 7683-7690 NNS denotes results
T4579 7736-7746 VBN denotes summarised
T4580 7691-7693 IN denotes of
T4581 7694-7697 DT denotes the
T4582 7709-7717 NN denotes analysis
T4583 7698-7708 JJ denotes phenotypic
T4584 7718-7720 IN denotes at
T4585 7721-7722 CD denotes 1
T4586 7723-7724 NN denotes y
T4587 7725-7727 IN denotes of
T4588 7728-7731 NN denotes age
T4589 7732-7735 VBP denotes are
T4590 7747-7749 IN denotes in
T4591 7750-7756 NNS denotes Tables
T4592 7757-7758 CD denotes 1
T4593 7759-7762 CC denotes and
T4594 7763-7764 CD denotes 2
T4595 7764-7765 . denotes .
T4596 7765-8010 sentence denotes As previously reported (Botto et al. 1998), the wild-type (129 × C57BL/6)F2 mice developed lupus traits with elevated levels of auto-Abs, starting from 6 mo of age (data not shown), and histological evidence of proliferative glomerulonephritis.
T4597 7766-7768 IN denotes As
T4598 7780-7788 VBN denotes reported
T4599 7769-7779 RB denotes previously
T4600 7847-7856 VBD denotes developed
T4601 7789-7790 -LRB- denotes (
T4602 7790-7795 NNP denotes Botto
T4603 7796-7798 FW denotes et
T4604 7799-7802 FW denotes al.
T4605 7803-7807 CD denotes 1998
T4606 7807-7808 -RRB- denotes )
T4607 7808-7810 , denotes ,
T4608 7810-7813 DT denotes the
T4609 7842-7846 NNS denotes mice
T4610 7814-7818 JJ denotes wild
T4611 7819-7823 NN denotes type
T4612 7818-7819 HYPH denotes -
T4613 7824-7825 -LRB- denotes (
T4614 7825-7828 CD denotes 129
T4615 7829-7830 SYM denotes ×
T4616 7831-7836 NN denotes C57BL
T4617 7836-7837 HYPH denotes /
T4618 7837-7838 CD denotes 6
T4619 7838-7839 -RRB- denotes )
T4620 7839-7841 NN denotes F2
T4621 7857-7862 NN denotes lupus
T4622 7863-7869 NNS denotes traits
T4623 7870-7874 IN denotes with
T4624 7875-7883 VBN denotes elevated
T4625 7884-7890 NNS denotes levels
T4626 7891-7893 IN denotes of
T4627 7894-7902 NNS denotes auto-Abs
T4628 7902-7904 , denotes ,
T4629 7904-7912 VBG denotes starting
T4630 7913-7917 IN denotes from
T4631 7918-7919 CD denotes 6
T4632 7920-7922 NN denotes mo
T4633 7923-7925 IN denotes of
T4634 7926-7929 NN denotes age
T4635 7930-7931 -LRB- denotes (
T4636 7940-7945 VBN denotes shown
T4637 7931-7935 NNS denotes data
T4638 7936-7939 RB denotes not
T4639 7945-7946 -RRB- denotes )
T4640 7946-7948 , denotes ,
T4641 7948-7951 CC denotes and
T4642 7952-7964 JJ denotes histological
T4643 7965-7973 NN denotes evidence
T4644 7974-7976 IN denotes of
T4645 7977-7990 JJ denotes proliferative
T4646 7991-8009 NN denotes glomerulonephritis
T4647 8009-8010 . denotes .
T4648 8010-8249 sentence denotes In agreement with our previous observations (Bickerstaff et al. 1999), the titres of anti-nuclear Abs (ANAs) and anti-chromatin Ab were considerably greater in the (129 × C57BL/6)F2.Apcs −/− mice compared with the strain-matched controls.
T4649 8011-8013 IN denotes In
T4650 8142-8146 VBD denotes were
T4651 8014-8023 NN denotes agreement
T4652 8024-8028 IN denotes with
T4653 8029-8032 PRP$ denotes our
T4654 8042-8054 NNS denotes observations
T4655 8033-8041 JJ denotes previous
T4656 8055-8056 -LRB- denotes (
T4657 8056-8067 NNP denotes Bickerstaff
T4658 8068-8070 FW denotes et
T4659 8071-8074 FW denotes al.
T4660 8075-8079 CD denotes 1999
T4661 8079-8080 -RRB- denotes )
T4662 8080-8082 , denotes ,
T4663 8082-8085 DT denotes the
T4664 8086-8092 NNS denotes titres
T4665 8093-8095 IN denotes of
T4666 8096-8108 JJ denotes anti-nuclear
T4667 8109-8112 NNS denotes Abs
T4668 8113-8114 -LRB- denotes (
T4669 8114-8118 NNS denotes ANAs
T4670 8118-8119 -RRB- denotes )
T4671 8120-8123 CC denotes and
T4672 8124-8138 JJ denotes anti-chromatin
T4673 8139-8141 NN denotes Ab
T4674 8147-8159 RB denotes considerably
T4675 8160-8167 JJR denotes greater
T4676 8168-8170 IN denotes in
T4677 8171-8174 DT denotes the
T4678 8202-8206 NNS denotes mice
T4679 8175-8176 -LRB- denotes (
T4680 8176-8179 CD denotes 129
T4681 8190-8192 NN denotes F2
T4682 8180-8181 SYM denotes ×
T4683 8182-8187 NN denotes C57BL
T4684 8187-8188 HYPH denotes /
T4685 8188-8189 CD denotes 6
T4686 8189-8190 -RRB- denotes )
T4687 8192-8193 HYPH denotes .
T4688 8193-8197 NN denotes Apcs
T4689 8198-8199 SYM denotes −
T4690 8199-8200 HYPH denotes /
T4691 8200-8201 SYM denotes −
T4692 8207-8215 VBN denotes compared
T4693 8216-8220 IN denotes with
T4694 8221-8224 DT denotes the
T4695 8240-8248 NNS denotes controls
T4696 8225-8231 NN denotes strain
T4697 8232-8239 VBN denotes matched
T4698 8231-8232 HYPH denotes -
T4699 8248-8249 . denotes .
T4700 8249-8533 sentence denotes However, in contrast to our original findings, the levels of the other two disease serological markers analysed (anti-single-stranded DNA [ssDNA] and anti-double-stranded DNA [dsDNA] Abs) and the severity of the renal pathology were not different between the two experimental groups.
T4701 8250-8257 RB denotes However
T4702 8478-8482 VBD denotes were
T4703 8257-8259 , denotes ,
T4704 8259-8261 IN denotes in
T4705 8262-8270 NN denotes contrast
T4706 8271-8273 IN denotes to
T4707 8274-8277 PRP$ denotes our
T4708 8287-8295 NNS denotes findings
T4709 8278-8286 JJ denotes original
T4710 8295-8297 , denotes ,
T4711 8297-8300 DT denotes the
T4712 8301-8307 NNS denotes levels
T4713 8308-8310 IN denotes of
T4714 8311-8314 DT denotes the
T4715 8345-8352 NNS denotes markers
T4716 8315-8320 JJ denotes other
T4717 8321-8324 CD denotes two
T4718 8325-8332 NN denotes disease
T4719 8333-8344 JJ denotes serological
T4720 8353-8361 VBN denotes analysed
T4721 8362-8363 -LRB- denotes (
T4722 8433-8436 NNS denotes Abs
T4723 8363-8374 VBN denotes anti-single
T4724 8375-8383 VBN denotes stranded
T4725 8374-8375 HYPH denotes -
T4726 8384-8387 NN denotes DNA
T4727 8388-8389 -LRB- denotes [
T4728 8389-8394 NN denotes ssDNA
T4729 8394-8395 -RRB- denotes ]
T4730 8396-8399 CC denotes and
T4731 8400-8411 VBN denotes anti-double
T4732 8412-8420 VBN denotes stranded
T4733 8411-8412 HYPH denotes -
T4734 8421-8424 NN denotes DNA
T4735 8425-8426 -LRB- denotes [
T4736 8426-8431 NN denotes dsDNA
T4737 8431-8432 -RRB- denotes ]
T4738 8436-8437 -RRB- denotes )
T4739 8438-8441 CC denotes and
T4740 8442-8445 DT denotes the
T4741 8446-8454 NN denotes severity
T4742 8455-8457 IN denotes of
T4743 8458-8461 DT denotes the
T4744 8468-8477 NN denotes pathology
T4745 8462-8467 JJ denotes renal
T4746 8483-8486 RB denotes not
T4747 8487-8496 JJ denotes different
T4748 8497-8504 IN denotes between
T4749 8505-8508 DT denotes the
T4750 8526-8532 NNS denotes groups
T4751 8509-8512 CD denotes two
T4752 8513-8525 JJ denotes experimental
T4753 8532-8533 . denotes .
T4754 8533-8776 sentence denotes In view of the possibility of an association between the fixed 129-derived segment flanking the mutated Apcs gene and the autoimmune traits observed, the genome-wide linkage analysis of the two experimental cohorts was carried out separately.
T4755 8534-8536 IN denotes In
T4756 8753-8760 VBN denotes carried
T4757 8537-8541 NN denotes view
T4758 8542-8544 IN denotes of
T4759 8545-8548 DT denotes the
T4760 8549-8560 NN denotes possibility
T4761 8561-8563 IN denotes of
T4762 8564-8566 DT denotes an
T4763 8567-8578 NN denotes association
T4764 8579-8586 IN denotes between
T4765 8587-8590 DT denotes the
T4766 8609-8616 NN denotes segment
T4767 8591-8596 VBN denotes fixed
T4768 8597-8600 CD denotes 129
T4769 8601-8608 VBN denotes derived
T4770 8600-8601 HYPH denotes -
T4771 8617-8625 VBG denotes flanking
T4772 8626-8629 DT denotes the
T4773 8643-8647 NN denotes gene
T4774 8630-8637 VBN denotes mutated
T4775 8638-8642 NN denotes Apcs
T4776 8648-8651 CC denotes and
T4777 8652-8655 DT denotes the
T4778 8667-8673 NNS denotes traits
T4779 8656-8666 JJ denotes autoimmune
T4780 8674-8682 VBN denotes observed
T4781 8682-8684 , denotes ,
T4782 8684-8687 DT denotes the
T4783 8708-8716 NN denotes analysis
T4784 8688-8694 NN denotes genome
T4785 8695-8699 JJ denotes wide
T4786 8694-8695 HYPH denotes -
T4787 8700-8707 NN denotes linkage
T4788 8717-8719 IN denotes of
T4789 8720-8723 DT denotes the
T4790 8741-8748 NNS denotes cohorts
T4791 8724-8727 CD denotes two
T4792 8728-8740 JJ denotes experimental
T4793 8749-8752 VBD denotes was
T4794 8761-8764 RP denotes out
T4795 8765-8775 RB denotes separately
T4796 8775-8776 . denotes .
T6774 9672-9678 NN denotes marker
T6775 9660-9671 JJ denotes informative
T6776 9678-9679 . denotes .
T6777 9679-9786 sentence denotes A summary of the genome-wide linkage analysis for each of the disease traits measured is shown in Table 3.
T6778 9680-9681 DT denotes A
T6779 9682-9689 NN denotes summary
T6780 9769-9774 VBN denotes shown
T6781 9690-9692 IN denotes of
T6782 9693-9696 DT denotes the
T6783 9717-9725 NN denotes analysis
T6732 9445-9452 NN denotes Mapping
T6733 9453-9455 IN denotes of
T6734 9456-9460 NNS denotes Loci
T6735 9461-9473 VBG denotes Predisposing
T6736 9474-9476 IN denotes to
T6737 9477-9482 NN denotes Lupus
T6738 9483-9485 IN denotes in
T6739 9486-9489 DT denotes the
T6740 9497-9503 NN denotes Strain
T6741 9490-9496 NN denotes Hybrid
T6742 9504-9505 -LRB- denotes (
T6743 9505-9508 CD denotes 129
T6744 9509-9510 SYM denotes ×
T6745 9511-9516 NN denotes C57BL
T6746 9516-9517 HYPH denotes /
T6747 9517-9518 CD denotes 6
T6748 9518-9519 -RRB- denotes )
T6749 9519-9679 sentence denotes Mice were genotyped with 143 microsatellite markers distributed throughout the autosomes such that 98% of the genes were within 20 cM of an informative marker.
T6750 9520-9524 NNS denotes Mice
T6751 9530-9539 VBN denotes genotyped
T6752 9525-9529 VBD denotes were
T6753 9540-9544 IN denotes with
T6754 9545-9548 CD denotes 143
T6755 9564-9571 NNS denotes markers
T6756 9549-9563 NN denotes microsatellite
T6757 9572-9583 VBN denotes distributed
T6758 9584-9594 IN denotes throughout
T6759 9595-9598 DT denotes the
T6760 9599-9608 NNS denotes autosomes
T6761 9609-9613 JJ denotes such
T6762 9636-9640 VBD denotes were
T6763 9614-9618 IN denotes that
T6764 9619-9621 CD denotes 98
T6765 9621-9622 NN denotes %
T6766 9623-9625 IN denotes of
T6767 9626-9629 DT denotes the
T6768 9630-9635 NNS denotes genes
T6769 9641-9647 IN denotes within
T6770 9648-9650 CD denotes 20
T6771 9651-9653 NNS denotes cM
T6772 9654-9656 IN denotes of
T6773 9657-9659 DT denotes an
T6784 9697-9703 NN denotes genome
T6785 9704-9708 JJ denotes wide
T6786 9703-9704 HYPH denotes -
T6787 9709-9716 NN denotes linkage
T6788 9726-9729 IN denotes for
T6789 9730-9734 DT denotes each
T6790 9735-9737 IN denotes of
T6791 9738-9741 DT denotes the
T6792 9750-9756 NNS denotes traits
T6793 9742-9749 NN denotes disease
T6794 9757-9765 VBN denotes measured
T6795 9766-9768 VBZ denotes is
T6796 9775-9777 IN denotes in
T6797 9778-9783 NN denotes Table
T6798 9784-9785 CD denotes 3
T6799 9785-9786 . denotes .
T6800 9786-9870 sentence denotes The areas of linkage were defined according to the parental origin, 129 or C57BL/6.
T6801 9787-9790 DT denotes The
T6802 9791-9796 NNS denotes areas
T6803 9813-9820 VBN denotes defined
T6804 9797-9799 IN denotes of
T6805 9800-9807 NN denotes linkage
T6806 9808-9812 VBD denotes were
T6807 9821-9830 VBG denotes according
T6808 9831-9833 IN denotes to
T6809 9834-9837 DT denotes the
T6810 9847-9853 NN denotes origin
T6811 9838-9846 JJ denotes parental
T6812 9853-9855 , denotes ,
T6813 9855-9858 CD denotes 129
T6814 9859-9861 CC denotes or
T6815 9862-9867 NN denotes C57BL
T6816 9867-9868 HYPH denotes /
T6817 9868-9869 CD denotes 6
T6818 9869-9870 . denotes .
T6819 9870-10130 sentence denotes Only linkages identified in both experimental groups are reported in Table 3, with the exception of the Chromosome 1 distal segment, where the linkage analysis could not be applied to the (129 × C57BL/6)F2.Apcs −/− mice as this region was of fixed 129 origin.
T6820 9871-9875 RB denotes Only
T6821 9876-9884 NNS denotes linkages
T6822 9928-9936 VBN denotes reported
T6823 9885-9895 VBN denotes identified
T6824 9896-9898 IN denotes in
T6825 9899-9903 DT denotes both
T6826 9917-9923 NNS denotes groups
T6827 9904-9916 JJ denotes experimental
T6828 9924-9927 VBP denotes are
T6829 9937-9939 IN denotes in
T6830 9940-9945 NN denotes Table
T6831 9946-9947 CD denotes 3
T6832 9947-9949 , denotes ,
T6833 9949-9953 IN denotes with
T6834 9954-9957 DT denotes the
T6835 9958-9967 NN denotes exception
T6836 9968-9970 IN denotes of
T6837 9971-9974 DT denotes the
T6838 9995-10002 NN denotes segment
T6839 9975-9985 NN denotes Chromosome
T6840 9986-9987 CD denotes 1
T6841 9988-9994 JJ denotes distal
T6842 10002-10004 , denotes ,
T6843 10004-10009 WRB denotes where
T6844 10044-10051 VBN denotes applied
T6845 10010-10013 DT denotes the
T6846 10022-10030 NN denotes analysis
T6847 10014-10021 NN denotes linkage
T6848 10031-10036 MD denotes could
T6849 10037-10040 RB denotes not
T6850 10041-10043 VB denotes be
T6851 10052-10054 IN denotes to
T6852 10055-10058 DT denotes the
T6853 10086-10090 NNS denotes mice
T6854 10059-10060 -LRB- denotes (
T6855 10074-10076 NN denotes F2
T6856 10060-10063 CD denotes 129
T6857 10064-10065 SYM denotes ×
T6858 10066-10071 NN denotes C57BL
T6859 10071-10072 HYPH denotes /
T6860 10072-10073 CD denotes 6
T6861 10073-10074 -RRB- denotes )
T6862 10076-10077 HYPH denotes .
T6863 10077-10081 NN denotes Apcs
T6864 10082-10083 SYM denotes −
T6865 10083-10084 HYPH denotes /
T6866 10084-10085 SYM denotes −
T6867 10091-10093 IN denotes as
T6868 10106-10109 VBD denotes was
T6869 10094-10098 DT denotes this
T6870 10099-10105 NN denotes region
T6871 10110-10112 IN denotes of
T6872 10113-10118 VBN denotes fixed
T6873 10123-10129 NN denotes origin
T6874 10119-10122 CD denotes 129
T6875 10129-10130 . denotes .
T6876 10130-10227 sentence denotes Chromosomes where linkages were present only in one of the two cohorts are shown in Figures 1–3.
T6877 10131-10142 NNS denotes Chromosomes
T6878 10206-10211 VBN denotes shown
T6879 10143-10148 WRB denotes where
T6880 10158-10162 VBD denotes were
T6881 10149-10157 NNS denotes linkages
T6882 10163-10170 JJ denotes present
T6883 10171-10175 RB denotes only
T6884 10176-10178 IN denotes in
T6885 10179-10182 CD denotes one
T6886 10183-10185 IN denotes of
T6887 10186-10189 DT denotes the
T6888 10194-10201 NNS denotes cohorts
T6889 10190-10193 CD denotes two
T6890 10202-10205 VBP denotes are
T6891 10212-10214 IN denotes in
T6892 10215-10222 NNS denotes Figures
T6893 10223-10224 CD denotes 1
T6894 10224-10225 SYM denotes –
T6895 10225-10226 CD denotes 3
T6896 10226-10227 . denotes .
T17705 35157-35158 CD denotes 6
T17704 35154-35156 IN denotes at
T17703 35144-35153 VBN denotes collected
T17702 35142-35144 , denotes ,
T17701 35182-35189 VBN denotes assayed
T17700 35138-35142 NNS denotes Sera
T17699 35137-35219 sentence denotes Sera, collected at 6 and 12 mo of age, were assayed for the presence of auto-Abs.
T17698 35136-35137 . denotes .
T17697 35128-35136 NNS denotes analyses
T17696 35116-35127 JJ denotes Serological
T14172 25100-25105 NN denotes C57BL
T15731 33048-33049 . denotes .
T17159 35113-35114 . denotes .
T17707 35159-35162 CC denotes and
T17706 35166-35168 NN denotes mo
T17957 36392-36393 . denotes .
T17956 36376-36384 JJ denotes negative
T17955 36385-36392 NN denotes control
T17954 36374-36375 DT denotes a
T17953 36371-36373 IN denotes as
T17952 36358-36361 VBD denotes was
T17951 36362-36370 VBN denotes included
T17950 36346-36351 NN denotes mouse
T17949 36344-36345 SYM denotes −
T17948 36343-36344 HYPH denotes /
T17947 36342-36343 SYM denotes −
T17946 36352-36357 NN denotes serum
T17945 36337-36341 NN denotes Apcs
T17944 36336-36393 sentence denotes Apcs −/− mouse serum was included as a negative control.
T17943 36335-36336 . denotes .
T17942 36334-36335 -RRB- denotes )
T17941 36324-36334 NNP denotes Calbiochem
T17940 36323-36324 -LRB- denotes (
T17939 36318-36322 NN denotes Apcs
T17938 36315-36317 IN denotes of
T17937 36295-36300 VBN denotes known
T17936 36301-36314 NN denotes concentration
T17935 36293-36294 DT denotes a
T17934 36288-36292 IN denotes with
T17933 36275-36276 HYPH denotes -
T17932 36276-36281 NN denotes phase
T17931 36270-36275 JJ denotes acute
T17930 36282-36287 NN denotes serum
T17929 36267-36269 DT denotes an
T17928 36262-36266 IN denotes from
T17927 36254-36261 VBN denotes derived
T17926 36239-36247 JJ denotes standard
T17925 36248-36253 NN denotes curve
T17924 36237-36238 DT denotes a
T17923 36234-36236 IN denotes to
T17922 36224-36233 VBG denotes referring
T17921 36222-36224 , denotes ,
T17920 36216-36222 NNS denotes liters
T18345 36927-36929 IN denotes of
T18344 36923-36925 CD denotes 75
T18343 36925-36926 NN denotes %
T18342 36922-36923 SYM denotes –
T18341 36921-36922 NN denotes %
T18340 36919-36921 CD denotes 50
T18339 36916-36918 IN denotes in
T18338 36900-36910 JJ denotes glomerular
T18368 37056-37057 . denotes .
T18367 37047-37056 NNS denotes glomeruli
T18366 37044-37046 IN denotes of
T18365 37042-37043 NN denotes %
T18364 37035-37039 IN denotes than
T18363 37040-37042 CD denotes 25
T18362 37027-37034 JJR denotes greater
T18361 37024-37026 IN denotes in
T18360 37014-37023 NNS denotes crescents
T18359 37011-37013 CC denotes or
T18358 37001-37010 NNS denotes glomeruli
T18357 36998-37000 IN denotes of
T18356 36996-36997 NN denotes %
T18355 36989-36993 IN denotes than
T18354 36994-36996 CD denotes 75
T18353 36981-36988 JJR denotes greater
T18352 36978-36980 IN denotes in
T18351 36950-36960 JJ denotes glomerular
T18350 36948-36950 , denotes ,
T18349 36947-36948 CD denotes 3
T18348 36941-36946 NN denotes grade
T18347 36939-36940 : denotes ;
T18346 36930-36939 NNS denotes glomeruli
T18550 37129-37134 NN denotes range
T18549 37124-37128 IN denotes with
T18548 37117-37123 NN denotes median
T18547 37114-37116 IN denotes as
T18546 37100-37103 VBP denotes are
T18545 37104-37113 VBN denotes expressed
T18544 37095-37099 NNS denotes data
T18543 37080-37094 JJ denotes Non-parametric
T18542 37079-37160 sentence denotes Non-parametric data are expressed as median with range of values in parentheses.
T18541 37071-37079 NN denotes analysis
T18540 37059-37070 JJ denotes Statistical
T18841 37697-37704 NN denotes request
T18840 37694-37696 IN denotes on
T18839 37679-37683 NN denotes list
T18838 37684-37693 JJ denotes available
T18837 37678-37679 -LRB- denotes (
T18836 37658-37669 JJ denotes polymorphic
T18835 37670-37677 NNS denotes markers
T18834 37654-37657 CD denotes 143
T18833 37648-37653 VBG denotes using
T18832 37644-37647 NN denotes DNA
T18831 37636-37643 JJ denotes genomic
T18830 37633-37635 IN denotes of
T18829 37629-37632 NN denotes PCR
T18828 37626-37628 IN denotes by
T18827 37622-37625 RP denotes out
T18826 37610-37613 VBD denotes was
T18825 37614-37621 VBN denotes carried
T18824 37599-37609 NN denotes Genotyping
T18823 37598-37746 sentence denotes Genotyping was carried out by PCR of genomic DNA using 143 polymorphic markers (list available on request) distributed throughout all 19 autosomes.
T18822 37590-37598 NN denotes analysis
T18821 37580-37589 JJ denotes Genotypic
T18902 38046-38047 . denotes .
T18901 38037-38041 VBD denotes were
T18900 38032-38036 NNS denotes gels
T18899 38016-38017 HYPH denotes -
T18898 38017-38031 NN denotes polyacrylamide
T18897 38013-38016 NN denotes SDS
T18896 38010-38012 IN denotes on
T18895 38007-38009 CC denotes or
T18894 37994-38001 NN denotes agarose
T18893 38002-38006 NNS denotes gels
T18892 37985-37986 HYPH denotes -
T18891 37986-37993 VBN denotes stained
T18890 37978-37985 NN denotes bromide
T18889 37969-37977 NN denotes ethidium
T18888 37966-37968 IN denotes on
T18887 37955-37965 JJ denotes detectable
T18886 37943-37954 NNS denotes differences
T18885 37938-37942 IN denotes with
T18884 38042-38046 VBN denotes used
T18883 37930-37937 NNS denotes primers
T18882 37925-37929 RB denotes Only
T18881 37924-38047 sentence denotes Only primers with differences detectable on ethidium bromide-stained agarose gels or on SDS-polyacrylamide gels were used.
T18880 37923-37924 . denotes .
T18879 37917-37918 CD denotes 6
T18878 37916-37917 HYPH denotes /
T18877 37911-37916 NN denotes C57BL
T18876 37907-37910 CC denotes and
T18875 37919-37923 NNS denotes mice
T18874 37903-37906 CD denotes 129
T18873 37895-37902 IN denotes between
T18872 37881-37894 NNS denotes polymorphisms
T18871 37876-37880 NN denotes size
T18870 37872-37875 IN denotes for
T18869 37858-37862 VBD denotes were
T18868 37863-37871 VBN denotes screened
T18867 37850-37857 NNS denotes markers
T18866 37835-37849 NN denotes Microsatellite
T18865 37834-37924 sentence denotes Microsatellite markers were screened for size polymorphisms between 129 and C57BL/6 mice.
T18864 37833-37834 . denotes .
T18863 37826-37833 NNS denotes primers
T18862 37823-37825 NN denotes μM
T18861 37819-37822 CD denotes 0.4
T19175 38157-38160 CD denotes two
T19174 38174-38180 NNS denotes groups
T19173 38153-38156 DT denotes the
T19172 38149-38152 CC denotes and
T19171 38147-38149 , denotes ,
T19170 38139-38142 VBD denotes was
T19169 38137-38138 -RRB- denotes )
T19168 38098-38137 NN denotes ftp://mcbio.med.buffalo.edu/pub/MapMgr/
T19167 38097-38098 -LRB- denotes (
T19166 38082-38096 NNP denotes MAPMANAGER.QTL
T19165 38143-38147 VBN denotes used
T19164 38070-38073 NN denotes QTL
T19163 38074-38081 NN denotes program
T19162 38066-38069 DT denotes The
T19161 38065-38209 sentence denotes The QTL program MAPMANAGER.QTL (ftp://mcbio.med.buffalo.edu/pub/MapMgr/) was used, and the two experimental groups were examined independently.
T19160 38057-38065 NN denotes analysis
T19159 38049-38056 NN denotes Linkage
T8933 19167-19168 SYM denotes ×
R2 T555 T556 amod Spontaneous,Autoimmunity
R3 T556 T558 dep Autoimmunity,Implications
R4 T559 T556 prep in,Autoimmunity
R5 T560 T561 nummod 129,Mice
R6 T561 T559 pobj Mice,in
R7 T562 T560 cc and,129
R8 T563 T560 conj C57BL,129
R9 T564 T563 punct /,C57BL
R10 T565 T563 nummod 6,C57BL
R11 T566 T558 punct —,Implications
R12 T567 T558 prep for,Implications
R13 T568 T567 pobj Autoimmunity,for
R14 T569 T558 acl Described,Implications
R15 T570 T569 prep in,Described
R16 T571 T572 npadvmod Gene,Targeted
R18 T573 T572 punct -,Targeted
R19 T574 T570 pobj Mice,in
R20 T578 T579 amod Systemic,erythematosus
R22 T580 T579 compound lupus,erythematosus
R23 T582 T583 punct (,SLE
R24 T583 T579 appos SLE,erythematosus
R25 T584 T583 punct ),SLE
R26 T585 T586 det a,disorder
R27 T586 T581 attr disorder,is
R28 T587 T586 amod multisystem,disorder
R29 T588 T586 amod autoimmune,disorder
R30 T589 T590 prep in,play
R31 T590 T586 relcl play,disorder
R32 T591 T589 pobj which,in
R33 T592 T593 amod complex,factors
R34 T593 T590 nsubj factors,play
R35 T594 T593 amod genetic,factors
R36 T595 T596 det an,role
R38 T597 T596 amod important,role
R39 T598 T581 punct .,is
R40 T600 T601 amod Several,strains
R41 T601 T602 nsubjpass strains,reported
R42 T603 T601 prep of,strains
R43 T604 T605 npadvmod gene,targeted
R45 T606 T605 punct -,targeted
R46 T607 T603 pobj mice,of
R47 T608 T602 aux have,reported
R48 T609 T602 auxpass been,reported
R49 T610 T611 aux to,develop
R50 T611 T602 xcomp develop,reported
R51 T612 T611 dobj SLE,develop
R52 T613 T602 punct ", ",reported
R53 T614 T602 advcl implicating,reported
R54 T615 T616 det the,genes
R56 T617 T616 amod null,genes
R57 T618 T614 prep in,implicating
R58 T619 T620 det the,causation
R59 T620 T618 pobj causation,in
R60 T621 T620 prep of,causation
R61 T622 T621 pobj disease,of
R62 T623 T602 punct .,reported
R63 T625 T626 advmod However,develop
R64 T627 T626 punct ", ",develop
R65 T628 T629 amod hybrid,strains
R66 T629 T626 nsubj strains,develop
R67 T630 T629 prep between,strains
R68 T631 T632 nummod 129,mice
R69 T632 T630 pobj mice,between
R70 T633 T631 cc and,129
R71 T634 T631 conj C57BL,129
R72 T635 T634 punct /,C57BL
R73 T636 T634 nummod 6,C57BL
R74 T637 T629 punct ", ",strains
R75 T638 T639 advmod widely,used
R76 T639 T629 acl used,strains
R77 T640 T639 prep in,used
R78 T641 T642 det the,generation
R79 T642 T640 pobj generation,in
R80 T643 T642 prep of,generation
R81 T644 T645 npadvmod gene,targeted
R83 T646 T645 punct -,targeted
R84 T647 T643 pobj mice,of
R85 T648 T626 punct ", ",develop
R86 T649 T650 amod spontaneous,autoimmunity
R87 T650 T626 dobj autoimmunity,develop
R88 T651 T626 punct .,develop
R89 T653 T654 advmod Furthermore,influences
R90 T655 T654 punct ", ",influences
R91 T656 T657 det the,background
R93 T658 T657 amod genetic,background
R94 T659 T654 advmod markedly,influences
R95 T660 T661 det the,phenotype
R97 T662 T661 amod autoimmune,phenotype
R98 T663 T661 prep of,phenotype
R99 T664 T663 pobj SLE,of
R100 T665 T654 prep in,influences
R101 T666 T667 npadvmod gene,targeted
R103 T668 T667 punct -,targeted
R104 T669 T665 pobj mice,in
R105 T670 T654 punct .,influences
R106 T672 T673 nsubj This,suggests
R107 T674 T675 det an,role
R109 T676 T675 amod important,role
R110 T677 T675 prep in,role
R111 T678 T679 det the,expression
R112 T679 T677 pobj expression,in
R113 T680 T679 prep of,expression
R114 T681 T680 pobj autoimmunity,of
R115 T682 T679 prep of,expression
R116 T683 T684 advmod as,yet
R118 T685 T684 punct -,yet
R120 T687 T686 punct -,uncharacterised
R122 T689 T688 compound background,genes
R123 T690 T688 acl originating,genes
R124 T691 T690 prep from,originating
R125 T692 T693 det these,strains
R126 T693 T691 pobj strains,from
R127 T694 T693 amod parental,strains
R128 T695 T693 compound mouse,strains
R129 T696 T673 punct .,suggests
R130 T698 T699 advcl Using,identified
R131 T700 T701 npadvmod genome,wide
R133 T702 T701 punct -,wide
R135 T704 T703 compound linkage,analysis
R136 T705 T699 punct ", ",identified
R137 T706 T699 nsubj we,identified
R138 T707 T708 amod several,loci
R140 T709 T708 compound susceptibility,loci
R141 T710 T708 punct ", ",loci
R142 T711 T708 acl derived,loci
R143 T712 T711 prep from,derived
R144 T713 T714 nummod 129,mice
R145 T714 T712 pobj mice,from
R146 T715 T713 cc and,129
R147 T716 T713 conj C57BL,129
R148 T717 T716 punct /,C57BL
R149 T718 T716 nummod 6,C57BL
R150 T719 T708 punct ", ",loci
R151 T720 T708 acl mapped,loci
R152 T721 T720 prep in,mapped
R153 T722 T723 det the,model
R154 T723 T721 pobj model,in
R155 T724 T725 npadvmod lupus,prone
R156 T725 T723 amod prone,model
R157 T726 T725 punct -,prone
R158 T727 T723 nmod hybrid,model
R159 T728 T729 punct (,129
R160 T729 T723 parataxis 129,model
R161 T730 T729 punct ×,129
R162 T731 T729 appos C57BL,129
R163 T732 T731 punct /,C57BL
R164 T733 T731 nummod 6,C57BL
R165 T734 T729 punct ),129
R166 T735 T699 punct .,identified
R167 T737 T738 prep By,found
R168 T739 T737 pcomp creating,By
R169 T740 T741 det a,strain
R170 T741 T739 dobj strain,creating
R171 T742 T741 nmod C57BL,strain
R172 T743 T742 punct /,C57BL
R173 T744 T742 nummod 6,C57BL
R174 T745 T741 amod congenic,strain
R175 T746 T741 acl carrying,strain
R176 T747 T748 det a,segment
R177 T748 T746 dobj segment,carrying
R178 T749 T750 advmod 129,derived
R179 T750 T748 amod derived,segment
R180 T751 T750 punct -,derived
R181 T752 T748 nmod Chromosome,segment
R182 T753 T752 nummod 1,Chromosome
R183 T754 T738 punct ", ",found
R184 T755 T738 nsubj we,found
R185 T756 T757 mark that,was
R186 T757 T738 ccomp was,found
R187 T758 T759 det this,interval
R188 T759 T757 nsubj interval,was
R189 T760 T759 nummod 129,interval
R190 T761 T757 acomp sufficient,was
R191 T762 T763 aux to,mediate
R192 T763 T761 xcomp mediate,sufficient
R193 T764 T765 det the,loss
R194 T765 T763 dobj loss,mediate
R195 T766 T765 prep of,loss
R196 T767 T766 pobj tolerance,of
R197 T768 T767 prep to,tolerance
R198 T769 T770 amod nuclear,antigens
R199 T770 T768 pobj antigens,to
R200 T771 T765 punct ", ",loss
R201 T772 T773 dep which,attributed
R202 T773 T765 relcl attributed,loss
R203 T774 T773 aux had,attributed
R204 T775 T773 advmod previously,attributed
R205 T776 T773 auxpass been,attributed
R206 T777 T773 prep to,attributed
R207 T778 T779 det a,gene
R209 T780 T779 amod disrupted,gene
R210 T781 T738 punct .,found
R211 T783 T784 det These,results
R212 T784 T785 nsubj results,demonstrate
R213 T786 T787 amod important,modifiers
R215 T788 T787 amod epistatic,modifiers
R216 T789 T787 prep of,modifiers
R217 T790 T789 pobj autoimmunity,of
R218 T791 T790 prep in,autoimmunity
R219 T792 T793 nummod 129,strains
R220 T793 T791 pobj strains,in
R221 T794 T792 cc and,129
R222 T795 T792 conj C57BL,129
R223 T796 T795 punct /,C57BL
R224 T797 T795 nummod 6,C57BL
R225 T798 T793 compound mouse,strains
R226 T799 T790 punct ", ",autoimmunity
R227 T800 T801 advmod widely,used
R228 T801 T790 acl used,autoimmunity
R229 T802 T801 prep in,used
R230 T803 T804 compound gene,targeting
R231 T804 T802 pobj targeting,in
R232 T805 T785 punct .,demonstrate
R233 T807 T808 det These,influences
R234 T808 T811 nsubj influences,account
R235 T809 T808 compound background,influences
R236 T810 T808 compound gene,influences
R237 T812 T811 aux may,account
R238 T813 T811 prep for,account
R239 T814 T813 pobj some,for
R240 T815 T814 punct ", ",some
R241 T816 T814 cc or,some
R242 T817 T818 advmod even,all
R243 T818 T814 conj all,some
R244 T819 T814 punct ", ",some
R245 T820 T814 prep of,some
R246 T821 T822 det the,traits
R248 T823 T822 amod autoimmune,traits
R249 T824 T822 acl described,traits
R250 T825 T824 prep in,described
R251 T826 T827 det some,models
R252 T827 T825 pobj models,in
R253 T828 T829 npadvmod gene,targeted
R254 T829 T827 amod targeted,models
R255 T830 T829 punct -,targeted
R256 T831 T827 prep of,models
R257 T832 T831 pobj SLE,of
R258 T833 T811 punct .,account
R263 T2804 T2805 amod Systemic,erythematosus
R264 T2805 T2807 nsubj erythematosus,is
R265 T2806 T2805 compound lupus,erythematosus
R266 T2808 T2805 punct (,erythematosus
R267 T2809 T2805 appos SLE,erythematosus
R268 T2810 T2805 punct ),erythematosus
R269 T2811 T2812 det a,disease
R270 T2812 T2807 attr disease,is
R271 T2813 T2812 amod chronic,disease
R272 T2814 T2812 amod autoimmune,disease
R273 T2815 T2812 acl characterised,disease
R274 T2816 T2815 agent by,characterised
R275 T2817 T2818 det the,production
R276 T2818 T2816 pobj production,by
R277 T2819 T2818 prep of,production
R278 T2820 T2819 pobj autoantibodies,of
R279 T2821 T2820 punct (,autoantibodies
R280 T2822 T2820 appos auto-Abs,autoantibodies
R281 T2823 T2820 punct ),autoantibodies
R282 T2824 T2818 prep against,production
R283 T2825 T2826 det a,spectrum
R284 T2826 T2824 pobj spectrum,against
R285 T2827 T2826 amod wide,spectrum
R286 T2828 T2826 prep of,spectrum
R287 T2829 T2830 compound self,antigens
R288 T2830 T2828 pobj antigens,of
R289 T2831 T2830 punct -,antigens
R290 T2832 T2830 punct ", ",antigens
R291 T2833 T2834 advmod mainly,from
R292 T2834 T2830 prep from,antigens
R293 T2835 T2836 amod subcellular,compartments
R294 T2836 T2834 pobj compartments,from
R295 T2837 T2836 punct ", ",compartments
R296 T2838 T2839 advmod especially,nucleus
R297 T2839 T2836 appos nucleus,compartments
R298 T2840 T2839 det the,nucleus
R299 T2841 T2839 compound cell,nucleus
R300 T2842 T2807 punct .,is
R301 T2925 T2924 pobj autoimmunity,of
R302 T2844 T2845 amod Genetic,predisposition
R303 T2926 T2922 acl generated,models
R304 T2845 T2846 nsubj predisposition,is
R305 T2927 T2926 prep by,generated
R306 T2928 T2929 amod targeted,disruption
R307 T2847 T2848 det an,contributor
R308 T2929 T2927 pobj disruption,by
R309 T2930 T2929 prep of,disruption
R310 T2931 T2932 amod specific,genes
R311 T2932 T2930 pobj genes,of
R312 T2933 T2932 acl modulating,genes
R313 T2934 T2935 det the,system
R314 T2935 T2933 dobj system,modulating
R315 T2936 T2935 amod immune,system
R316 T2937 T2906 aux have,used
R317 T2938 T2906 advmod widely,used
R318 T2939 T2906 auxpass been,used
R319 T2940 T2941 aux to,investigate
R320 T2848 T2846 attr contributor,is
R321 T2941 T2906 advcl investigate,used
R322 T2942 T2943 det the,complexity
R323 T2943 T2941 dobj complexity,investigate
R324 T2944 T2943 prep of,complexity
R325 T2849 T2848 amod important,contributor
R326 T2945 T2944 pobj SLE,of
R327 T2850 T2848 prep to,contributor
R328 T2946 T2906 punct .,used
R329 T2851 T2850 pobj susceptibility,to
R330 T2948 T2949 det The,strains
R331 T2852 T2851 prep to,susceptibility
R332 T2949 T2953 nsubj strains,are
R333 T2950 T2951 advmod best,studied
R334 T2951 T2949 amod studied,strains
R335 T2853 T2852 pobj SLE,to
R336 T2952 T2951 punct -,studied
R337 T2954 T2949 prep of,strains
R338 T2854 T2846 prep in,is
R339 T2955 T2954 pobj mice,of
R340 T2956 T2957 dep that,develop
R341 T2855 T2856 preconj both,humans
R342 T2957 T2955 relcl develop,mice
R343 T2958 T2957 advmod spontaneously,develop
R344 T2856 T2854 pobj humans,in
R345 T2959 T2960 det a,pathology
R346 T2960 T2957 dobj pathology,develop
R347 T2961 T2962 npadvmod lupus,like
R348 T2857 T2856 cc and,humans
R349 T2962 T2960 amod like,pathology
R350 T2963 T2962 punct -,like
R351 T2858 T2856 conj animals,humans
R352 T2964 T2965 det the,strain
R353 T2965 T2953 attr strain,are
R354 T2966 T2967 nmod New,Zealand
R355 T2859 T2860 punct (,Vyse
R356 T2967 T2968 nmod Zealand,Black
R357 T2968 T2965 nmod Black,strain
R358 T2969 T2968 punct /,Black
R359 T2860 T2846 meta Vyse,is
R360 T2970 T2971 compound New,Zealand
R361 T2971 T2972 compound Zealand,White
R362 T2972 T2968 appos White,Black
R363 T2973 T2965 compound hybrid,strain
R364 T2974 T2975 punct (,WF1
R365 T2975 T2965 parataxis WF1,strain
R366 T2976 T2975 compound NZB,WF1
R367 T2977 T2975 punct /,WF1
R368 T2861 T2860 cc and,Vyse
R369 T2978 T2975 punct ),WF1
R370 T2979 T2965 punct ;,strain
R371 T2980 T2981 det the,strain
R372 T2862 T2860 conj Todd,Vyse
R373 T2863 T2862 nummod 1996,Todd
R374 T2981 T2965 conj strain,strain
R375 T2864 T2862 punct ;,Todd
R376 T2982 T2983 compound MRL,Mp
R377 T2983 T2981 compound Mp,strain
R378 T2984 T2983 punct /,Mp
R379 T2865 T2862 conj Harley,Todd
R380 T2985 T2986 compound lpr,lpr
R381 T2986 T2981 compound lpr,strain
R382 T2987 T2986 punct /,lpr
R383 T2866 T2865 nmod et,Harley
R384 T2988 T2981 punct ", ",strain
R385 T2989 T2990 dep which,carries
R386 T2990 T2981 relcl carries,strain
R387 T2867 T2865 nmod al.,Harley
R388 T2991 T2992 det the,mutation
R389 T2868 T2865 nummod 1998,Harley
R390 T2992 T2990 dobj mutation,carries
R391 T2993 T2992 compound lpr,mutation
R392 T2994 T2992 prep of,mutation
R393 T2995 T2996 det the,gene
R394 T2869 T2865 punct ;,Harley
R395 T2870 T2865 conj Theofilopoulos,Harley
R396 T2996 T2994 pobj gene,of
R397 T2997 T2998 compound FAS,receptor
R398 T2998 T2996 compound receptor,gene
R399 T2999 T2981 punct ;,strain
R400 T2871 T2870 cc and,Theofilopoulos
R401 T3000 T2981 cc and,strain
R402 T3001 T3002 det the,strain
R403 T3002 T2981 conj strain,strain
R404 T2872 T2870 conj Kono,Theofilopoulos
R405 T3003 T3002 compound BXSB,strain
R406 T3004 T3002 punct ", ",strain
R407 T3005 T3006 dep which,carries
R408 T2873 T2872 nummod 1999,Kono
R409 T3006 T3002 relcl carries,strain
R410 T3007 T3008 det the,gene
R411 T3008 T3006 dobj gene,carries
R412 T2874 T2872 punct ;,Kono
R413 T3009 T3010 nmod Y,chromosome
R414 T3010 T3011 nmod chromosome,accelerator
R415 T3011 T3008 nmod accelerator,gene
R416 T3012 T3011 amod autoimmune,accelerator
R417 T3013 T3011 punct (,accelerator
R418 T3014 T3011 appos Yaa,accelerator
R419 T2875 T2872 conj Wakeland,Kono
R420 T3015 T3011 punct ),accelerator
R421 T3016 T3017 punct (,Theofilopoulos
R422 T3017 T3008 meta Theofilopoulos,gene
R423 T2876 T2875 nmod et,Wakeland
R424 T3018 T3017 cc and,Theofilopoulos
R425 T3019 T3017 conj Dixon,Theofilopoulos
R426 T3020 T3019 nummod 1985,Dixon
R427 T2877 T2875 nmod al.,Wakeland
R428 T3021 T3019 punct ),Dixon
R429 T3022 T2953 punct .,are
R430 T2878 T2875 nummod 2001,Wakeland
R431 T3024 T3025 amod Extensive,studies
R432 T3025 T3028 nsubj studies,identified
R433 T2879 T2875 punct ),Wakeland
R434 T3026 T3027 amod genetic,mapping
R435 T3027 T3025 compound mapping,studies
R436 T2880 T2846 punct .,is
R437 T3029 T3025 prep in,studies
R438 T3030 T3031 det all,strains
R439 T2882 T2883 nsubj Genes,participate
R440 T2884 T2882 prep in,Genes
R441 T2885 T2886 amod multiple,pathways
R442 T3031 T3029 pobj strains,in
R443 T3032 T3031 nummod three,strains
R444 T2886 T2884 pobj pathways,in
R445 T3033 T3028 aux have,identified
R446 T3034 T3035 amod multiple,intervals
R447 T2887 T2883 prep in,participate
R448 T3035 T3028 dobj intervals,identified
R449 T3036 T3035 acl associated,intervals
R450 T2888 T2887 pcomp mediating,in
R451 T3037 T3036 prep with,associated
R452 T3038 T3039 compound disease,susceptibility
R453 T3039 T3037 pobj susceptibility,with
R454 T2889 T2890 compound disease,pathogenesis
R455 T3040 T3028 punct .,identified
R456 T2890 T2888 dobj pathogenesis,mediating
R457 T3042 T3043 advmod Interestingly,are
R458 T3044 T3043 punct ", ",are
R459 T2891 T2883 punct ", ",participate
R460 T3045 T3046 det the,majority
R461 T3046 T3043 nsubj majority,are
R462 T3047 T3046 prep of,majority
R463 T2892 T2883 cc and,participate
R464 T3048 T3049 det the,intervals
R465 T3049 T3047 pobj intervals,of
R466 T2893 T2894 amod epistatic,interactions
R467 T3050 T3049 acl detected,intervals
R468 T3051 T3052 npadvmod strain,specific
R469 T3052 T3043 acomp specific,are
R470 T3053 T3052 punct -,specific
R471 T3054 T3043 punct ", ",are
R472 T3055 T3043 advcl confirming,are
R473 T2894 T2895 nsubj interactions,influence
R474 T3056 T3057 det the,complexity
R475 T3057 T3055 dobj complexity,confirming
R476 T3058 T3057 amod genetic,complexity
R477 T2895 T2883 conj influence,participate
R478 T3059 T3057 prep of,complexity
R479 T3060 T3061 det the,disease
R480 T3061 T3059 pobj disease,of
R481 T2896 T2894 prep amongst,interactions
R482 T3062 T3055 cc and,confirming
R483 T3063 T3055 conj indicating,confirming
R484 T3064 T3065 det the,presence
R485 T2897 T2898 det these,genes
R486 T3065 T3063 dobj presence,indicating
R487 T3066 T3065 prep of,presence
R488 T2898 T2896 pobj genes,amongst
R489 T2899 T2900 det the,expression
R490 T2900 T2895 dobj expression,influence
R491 T3067 T3068 amod extensive,heterogeneity
R492 T2901 T2900 prep of,expression
R493 T3068 T3066 pobj heterogeneity,of
R494 T3069 T3063 prep in,indicating
R495 T2902 T2901 pobj disease,of
R496 T3070 T3071 det the,genes
R497 T3071 T3069 pobj genes,in
R498 T2903 T2895 punct .,influence
R499 T3072 T3071 acl contributing,genes
R500 T3073 T3072 prep to,contributing
R501 T3074 T3075 det the,pathogenesis
R502 T2905 T2906 prep In,used
R503 T3075 T3073 pobj pathogenesis,to
R504 T3076 T3075 prep of,pathogenesis
R505 T3077 T3078 det the,disease
R506 T2907 T2908 det this,context
R507 T3078 T3076 pobj disease,of
R508 T3079 T3043 punct .,are
R509 T2908 T2905 pobj context,In
R510 T3081 T3082 advmod However,mapped
R511 T2909 T2906 punct ", ",used
R512 T3083 T3082 punct ", ",mapped
R513 T3084 T3085 det some,loci
R514 T3085 T3082 nsubjpass loci,mapped
R515 T2910 T2911 preconj both,studies
R516 T3086 T3085 compound susceptibility,loci
R517 T3087 T3082 aux have,mapped
R518 T2911 T2906 nsubjpass studies,used
R519 T3088 T3082 auxpass been,mapped
R520 T3089 T3082 prep to,mapped
R521 T3090 T3091 amod similar,locations
R522 T3091 T3089 pobj locations,to
R523 T3092 T3091 compound chromosome,locations
R524 T3093 T3091 prep in,locations
R525 T3094 T3095 amod different,strains
R526 T2912 T2913 amod genetic,linkage
R527 T3095 T3093 pobj strains,in
R528 T3096 T3082 punct ", ",mapped
R529 T3097 T3082 advcl suggesting,mapped
R530 T2913 T2911 compound linkage,studies
R531 T3098 T3099 mark that,shared
R532 T3099 T3097 ccomp shared,suggesting
R533 T3100 T3101 advmod at,least
R534 T2914 T2911 prep in,studies
R535 T3101 T3102 advmod least,susceptibility
R536 T3102 T3099 nsubjpass susceptibility,shared
R537 T3103 T3102 det some,susceptibility
R538 T2915 T2916 amod spontaneous,models
R539 T3104 T3099 aux may,shared
R540 T3105 T3099 auxpass be,shared
R541 T3106 T3099 prep amongst,shared
R542 T2916 T2914 pobj models,in
R543 T3107 T3108 npadvmod lupus,prone
R544 T3108 T3110 amod prone,strains
R545 T2917 T2918 npadvmod lupus,prone
R546 T3109 T3108 punct -,prone
R547 T3110 T3106 pobj strains,amongst
R548 T3111 T3082 punct .,mapped
R549 T2918 T2916 amod prone,models
R550 T3113 T3114 prep Amongst,are
R551 T2919 T2918 punct -,prone
R553 T3116 T3113 pobj loci,Amongst
R554 T2920 T2911 cc and,studies
R555 T3117 T3116 amod shared,loci
R556 T3118 T3116 compound susceptibility,loci
R557 T3119 T3114 punct ", ",are
R558 T2921 T2922 amod synthetic,models
R559 T3120 T3121 det the,striking
R560 T3121 T3114 nsubj striking,are
R561 T2922 T2911 conj models,studies
R562 T3122 T3121 advmod most,striking
R563 T3123 T3114 attr loci,are
R564 T3124 T3123 prep on,loci
R565 T2923 T2922 amod murine,models
R566 T3125 T3126 amod distal,Chromosome
R567 T3126 T3124 pobj Chromosome,on
R568 T3127 T3126 nummod 1,Chromosome
R569 T2924 T2922 prep of,models
R570 T3128 T3123 punct ", ",loci
R571 T3129 T3130 prep for,found
R572 T3130 T3123 relcl found,loci
R573 T3131 T3129 pobj which,for
R574 T3132 T3133 amod important,genes
R575 T3137 T3130 prep in,found
R576 T3133 T3130 nsubjpass genes,found
R577 T3134 T3133 amod contributing,genes
R578 T3138 T3139 nmod New,Zealand
R579 T3135 T3130 aux have,found
R580 T3136 T3130 auxpass been,found
R581 T3139 T3140 nmod Zealand,models
R582 T3140 T3137 pobj models,in
R583 T3141 T3139 cc and,Zealand
R584 T3243 T3244 advmod most,surprising
R585 T3142 T3139 conj BXSB,Zealand
R586 T3244 T3242 amod surprising,result
R587 T3245 T3242 prep of,result
R588 T3143 T3144 punct (,Theofilopoulos
R589 T3246 T3247 det this,approach
R590 T3247 T3245 pobj approach,of
R591 T3144 T3130 meta Theofilopoulos,found
R592 T3248 T3247 amod powerful,approach
R593 T3249 T3239 aux has,been
R594 T3145 T3144 cc and,Theofilopoulos
R595 T3250 T3251 det the,frequency
R596 T3251 T3239 attr frequency,been
R597 T3252 T3251 amod high,frequency
R598 T3146 T3144 conj Kono,Theofilopoulos
R599 T3253 T3254 prep with,associated
R600 T3254 T3251 relcl associated,frequency
R601 T3255 T3253 pobj which,with
R602 T3147 T3146 nummod 1999,Kono
R603 T3256 T3257 amod such,mutations
R604 T3257 T3254 nsubjpass mutations,associated
R605 T3258 T3254 aux have,associated
R606 T3148 T3146 punct ;,Kono
R607 T3259 T3254 auxpass been,associated
R608 T3260 T3254 prep with,associated
R609 T3261 T3262 det an,phenotype
R610 T3149 T3146 conj Wakeland,Kono
R611 T3262 T3260 pobj phenotype,with
R612 T3263 T3262 amod autoimmune,phenotype
R613 T3264 T3239 punct .,been
R614 T3150 T3149 nmod et,Wakeland
R615 T3266 T3267 prep In,is
R616 T3151 T3149 nmod al.,Wakeland
R617 T3268 T3269 det this,regard
R618 T3269 T3266 pobj regard,In
R619 T3152 T3149 nummod 2001,Wakeland
R620 T3270 T3267 punct ", ",is
R621 T3271 T3267 nsubj it,is
R622 T3272 T3267 prep of,is
R623 T3153 T3149 punct ),Wakeland
R624 T3273 T3272 pobj note,of
R625 T3274 T3275 mark that,are
R626 T3275 T3267 ccomp are,is
R627 T3276 T3277 amod hybrid,strains
R628 T3277 T3275 nsubj strains,are
R629 T3278 T3277 prep between,strains
R630 T3154 T3114 punct .,are
R631 T3279 T3280 nummod 129,mice
R632 T3280 T3278 pobj mice,between
R633 T3281 T3279 cc and,129
R634 T3156 T3157 mark Although,made
R635 T3282 T3279 conj C57BL,129
R636 T3283 T3282 punct /,C57BL
R637 T3284 T3282 nummod 6,C57BL
R638 T3285 T3277 punct ", ",strains
R639 T3157 T3162 advcl made,resolved
R640 T3286 T3287 advmod widely,used
R641 T3287 T3277 acl used,strains
R642 T3288 T3287 prep in,used
R643 T3158 T3159 amod considerable,efforts
R644 T3289 T3290 det the,generation
R645 T3290 T3288 pobj generation,in
R646 T3291 T3290 prep of,generation
R647 T3159 T3157 nsubjpass efforts,made
R648 T3292 T3293 npadvmod gene,targeted
R649 T3293 T3295 amod targeted,mice
R650 T3294 T3293 punct -,targeted
R651 T3160 T3157 aux have,made
R652 T3295 T3291 pobj mice,of
R653 T3296 T3275 punct ", ",are
R654 T3297 T3275 advmod spontaneously,are
R655 T3161 T3157 auxpass been,made
R656 T3298 T3275 acomp predisposed,are
R657 T3299 T3298 prep to,predisposed
R658 T3163 T3164 aux to,identify
R659 T3300 T3299 pobj development,to
R660 T3301 T3300 prep of,development
R661 T3302 T3303 amod humoral,autoimmunity
R662 T3303 T3301 pobj autoimmunity,of
R663 T3304 T3303 prep with,autoimmunity
R664 T3305 T3306 amod low,levels
R665 T3164 T3157 xcomp identify,made
R666 T3306 T3304 pobj levels,with
R667 T3307 T3306 prep of,levels
R668 T3165 T3166 det the,genes
R669 T3308 T3307 pobj glomerulonephritis,of
R670 T3309 T3310 punct (,Obata
R671 T3310 T3275 meta Obata,are
R672 T3166 T3164 dobj genes,identify
R673 T3311 T3310 nmod et,Obata
R674 T3312 T3310 nmod al.,Obata
R675 T3313 T3310 nummod 1979,Obata
R676 T3314 T3310 punct ;,Obata
R677 T3315 T3310 nmod Botto,Obata
R678 T3316 T3310 nmod et,Obata
R679 T3317 T3310 nmod al.,Obata
R680 T3167 T3166 amod responsible,genes
R681 T3318 T3310 nummod 1998,Obata
R682 T3319 T3310 punct ;,Obata
R683 T3320 T3310 nmod Bickerstaff,Obata
R684 T3168 T3167 prep for,responsible
R685 T3321 T3310 nmod et,Obata
R686 T3169 T3170 det the,development
R687 T3322 T3310 nmod al.,Obata
R688 T3323 T3310 nummod 1999,Obata
R689 T3170 T3168 pobj development,for
R690 T3324 T3310 punct ;,Obata
R691 T3325 T3310 nmod Santiago,Obata
R692 T3171 T3170 prep of,development
R693 T3326 T3310 punct -,Obata
R694 T3327 T3310 nmod Raber,Obata
R695 T3328 T3310 nmod et,Obata
R696 T3172 T3173 det the,disease
R697 T3329 T3310 nmod al.,Obata
R698 T3330 T3310 nummod 2001,Obata
R699 T3331 T3310 punct ),Obata
R700 T3173 T3171 pobj disease,of
R701 T3332 T3267 punct .,is
R702 T3174 T3162 punct ", ",resolved
R703 T3334 T3335 advmod Furthermore,influences
R704 T3336 T3335 punct ", ",influences
R705 T3175 T3162 prep with,resolved
R706 T3337 T3338 det the,background
R707 T3338 T3335 nsubj background,influences
R708 T3176 T3177 det the,exception
R709 T3339 T3338 amod genetic,background
R710 T3340 T3335 advmod markedly,influences
R711 T3341 T3342 det the,phenotype
R712 T3177 T3175 pobj exception,with
R713 T3342 T3335 dobj phenotype,influences
R714 T3343 T3342 amod autoimmune,phenotype
R715 T3344 T3335 prep in,influences
R716 T3178 T3177 prep of,exception
R717 T3345 T3346 npadvmod gene,targeted
R718 T3346 T3348 amod targeted,mice
R719 T3179 T3180 det the,mutation
R720 T3347 T3346 punct -,targeted
R721 T3348 T3344 pobj mice,in
R722 T3180 T3178 pobj mutation,of
R723 T3181 T3180 compound lpr,mutation
R724 T3349 T3350 punct (,Bolland
R725 T3182 T3162 punct ", ",resolved
R726 T3350 T3335 meta Bolland,influences
R727 T3351 T3350 cc and,Bolland
R728 T3352 T3350 conj Ravetch,Bolland
R729 T3353 T3352 nummod 2000,Ravetch
R730 T3354 T3352 punct ;,Ravetch
R731 T3183 T3162 nsubjpass none,resolved
R732 T3355 T3352 conj Santiago,Ravetch
R733 T3356 T3355 punct -,Santiago
R734 T3357 T3355 nmod Raber,Santiago
R735 T3184 T3183 prep of,none
R736 T3358 T3355 nmod et,Santiago
R737 T3359 T3355 nmod al.,Santiago
R738 T3360 T3355 nummod 2001,Santiago
R739 T3185 T3186 det the,contributions
R740 T3361 T3355 punct ;,Santiago
R741 T3362 T3355 conj Mitchell,Santiago
R742 T3363 T3362 nmod et,Mitchell
R743 T3186 T3184 pobj contributions,of
R744 T3364 T3362 nmod al.,Mitchell
R745 T3365 T3362 nummod 2002,Mitchell
R746 T3366 T3362 punct ),Mitchell
R747 T3187 T3186 amod genetic,contributions
R748 T3367 T3335 punct .,influences
R749 T3369 T3370 det These,observations
R750 T3188 T3186 prep to,contributions
R751 T3370 T3371 nsubj observations,led
R752 T3189 T3188 pobj disease,to
R753 T3372 T3371 prep to,led
R754 T3373 T3374 det the,hypothesis
R755 T3374 T3372 pobj hypothesis,to
R756 T3190 T3186 prep in,contributions
R757 T3375 T3376 mark that,be
R758 T3376 T3374 acl be,hypothesis
R759 T3377 T3378 det the,phenotype
R760 T3191 T3192 det the,strains
R761 T3378 T3376 nsubj phenotype,be
R762 T3379 T3378 amod autoimmune,phenotype
R763 T3192 T3190 pobj strains,in
R764 T3380 T3378 acl described,phenotype
R765 T3381 T3380 prep in,described
R766 T3382 T3383 det some,mice
R767 T3193 T3192 nummod three,strains
R768 T3383 T3381 pobj mice,in
R769 T3384 T3385 npadvmod gene,targeted
R770 T3385 T3383 amod targeted,mice
R771 T3194 T3195 advmod well,documented
R772 T3386 T3385 punct -,targeted
R773 T3387 T3376 aux might,be
R774 T3388 T3376 prep due,be
R775 T3195 T3192 amod documented,strains
R776 T3389 T3388 advmod primarily,due
R777 T3390 T3388 pcomp to,due
R778 T3196 T3195 punct -,documented
R779 T3391 T3388 pobj combinations,due
R780 T3197 T3192 amod murine,strains
R781 T3392 T3391 prep of,combinations
R782 T3393 T3394 advmod as,yet
R783 T3394 T3396 advmod yet,uncharacterised
R784 T3395 T3394 punct -,yet
R785 T3396 T3398 amod uncharacterised,genes
R786 T3397 T3396 punct -,uncharacterised
R787 T3398 T3392 pobj genes,of
R788 T3399 T3398 compound background,genes
R789 T3198 T3192 compound SLE,strains
R790 T3400 T3398 punct ", ",genes
R791 T3401 T3398 acl originating,genes
R792 T3402 T3401 prep from,originating
R793 T3199 T3162 aux have,resolved
R794 T3403 T3404 nummod 129,strains
R795 T3200 T3162 advmod yet,resolved
R796 T3404 T3402 pobj strains,from
R797 T3405 T3403 cc and,129
R798 T3201 T3162 auxpass been,resolved
R799 T3406 T3403 conj C57BL,129
R800 T3407 T3406 punct /,C57BL
R801 T3408 T3406 nummod 6,C57BL
R802 T3202 T3162 advmod fully,resolved
R803 T3409 T3404 compound mice,strains
R804 T3410 T3391 punct ", ",combinations
R805 T3411 T3391 acl interacting,combinations
R806 T3203 T3162 prep at,resolved
R807 T3412 T3411 cc or,interacting
R808 T3413 T3411 conj not,interacting
R809 T3414 T3411 prep with,interacting
R810 T3204 T3205 det the,level
R811 T3415 T3416 det the,allele
R812 T3416 T3414 pobj allele,with
R813 T3205 T3203 pobj level,at
R814 T3417 T3416 amod mutated,allele
R815 T3418 T3371 punct .,led
R816 T3206 T3207 amod molecular,protein
R817 T3420 T3421 aux To,test
R818 T3421 T3422 advcl test,conducted
R819 T3207 T3205 compound protein,level
R820 T3423 T3421 dobj this,test
R821 T3208 T3207 cc or,protein
R822 T3424 T3422 punct ", ",conducted
R823 T3425 T3422 nsubj we,conducted
R824 T3426 T3427 det a,analysis
R825 T3209 T3162 punct .,resolved
R826 T3427 T3422 dobj analysis,conducted
R827 T3428 T3429 npadvmod genome,wide
R828 T3211 T3212 advmod Thus,used
R829 T3429 T3427 amod wide,analysis
R830 T3430 T3429 punct -,wide
R831 T3431 T3427 compound scan,analysis
R832 T3432 T3427 prep of,analysis
R833 T3433 T3434 nummod two,cohorts
R834 T3434 T3432 pobj cohorts,of
R835 T3435 T3434 amod large,cohorts
R836 T3213 T3212 punct ", ",used
R837 T3436 T3434 prep of,cohorts
R838 T3437 T3438 punct (,mice
R839 T3438 T3436 pobj mice,of
R840 T3439 T3438 nummod 129,mice
R841 T3214 T3215 amod targeted,disruption
R842 T3440 T3439 punct ×,129
R843 T3441 T3439 appos C57BL,129
R844 T3442 T3441 punct /,C57BL
R845 T3443 T3441 nummod 6,C57BL
R846 T3215 T3212 nsubjpass disruption,used
R847 T3444 T3438 punct ),mice
R848 T3445 T3438 compound F2,mice
R849 T3446 T3434 punct ", ",cohorts
R850 T3216 T3215 amod genetic,disruption
R851 T3447 T3448 dep one,carried
R852 T3448 T3434 relcl carried,cohorts
R853 T3217 T3215 prep of,disruption
R854 T3449 T3447 prep of,one
R855 T3450 T3449 pobj which,of
R856 T3218 T3219 compound candidate,genes
R857 T3451 T3452 det a,mutation
R858 T3219 T3217 pobj genes,of
R859 T3452 T3448 dobj mutation,carried
R860 T3453 T3448 prep in,carried
R861 T3220 T3219 acl encoding,genes
R862 T3454 T3455 det the,gene
R863 T3221 T3220 dobj proteins,encoding
R864 T3222 T3221 prep of,proteins
R865 T3223 T3224 det the,system
R866 T3455 T3453 pobj gene,in
R867 T3456 T3457 compound serum,component
R868 T3224 T3222 pobj system,of
R869 T3457 T3455 compound component,gene
R870 T3458 T3457 compound amyloid,component
R871 T3459 T3457 compound P,component
R872 T3225 T3224 amod immune,system
R873 T3460 T3461 punct (,Apcs
R874 T3461 T3455 parataxis Apcs,gene
R875 T3462 T3461 punct ),Apcs
R876 T3226 T3212 aux has,used
R877 T3463 T3422 punct .,conducted
R878 T3227 T3212 auxpass been,used
R879 T3465 T3466 det The,mice
R880 T3466 T3470 nsubjpass mice,chosen
R881 T3467 T3468 npadvmod Apcs,deficient
R882 T3228 T3212 advmod extensively,used
R883 T3468 T3466 amod deficient,mice
R884 T3469 T3468 punct -,deficient
R885 T3470 T3478 ccomp chosen,persists
R886 T3471 T3472 punct (,Apcs
R887 T3472 T3466 parataxis Apcs,mice
R888 T3229 T3230 aux to,examine
R889 T3473 T3472 punct −,Apcs
R890 T3474 T3472 punct /,Apcs
R891 T3475 T3472 punct −,Apcs
R892 T3230 T3212 advcl examine,used
R893 T3476 T3472 punct ),Apcs
R894 T3477 T3470 auxpass were,chosen
R895 T3231 T3232 poss their,role
R896 T3479 T3470 prep as,chosen
R897 T3480 T3481 det an,example
R898 T3481 T3479 pobj example,as
R899 T3232 T3230 dobj role,examine
R900 T3482 T3481 prep of,example
R901 T3483 T3484 det a,strain
R902 T3233 T3232 prep in,role
R903 T3484 T3482 pobj strain,of
R904 T3485 T3486 npadvmod gene,targeted
R905 T3486 T3484 amod targeted,strain
R906 T3234 T3235 amod immune,regulation
R907 T3487 T3486 punct -,targeted
R908 T3488 T3489 advmod previously,reported
R909 T3489 T3484 acl reported,strain
R910 T3235 T3233 pobj regulation,in
R913 T3236 T3212 punct .,used
R914 T3238 T3239 advmod However,been
R915 T3492 T3493 det a,disease
R916 T3493 T3491 dobj disease,develop
R917 T3494 T3495 npadvmod lupus,like
R918 T3240 T3239 punct ", ",been
R919 T3495 T3493 amod like,disease
R920 T3496 T3495 punct -,like
R921 T3497 T3491 prep on,develop
R922 T3498 T3499 det the,C57BL
R923 T3241 T3242 det the,result
R924 T3499 T3497 pobj C57BL,on
R925 T3500 T3499 nmod hybrid,C57BL
R926 T3242 T3239 nsubj result,been
R927 T3501 T3499 amod genetic,C57BL
R928 T3502 T3499 nmod background,C57BL
R929 T3560 T3551 punct ", ",Chromosome
R930 T3503 T3499 punct (,C57BL
R931 T3504 T3499 nummod 129,C57BL
R932 T3505 T3499 punct ×,C57BL
R933 T3506 T3499 punct /,C57BL
R934 T3507 T3499 nummod 6,C57BL
R935 T3508 T3499 punct ),C57BL
R936 T3561 T3551 prep within,Chromosome
R937 T3509 T3478 punct ;,persists
R938 T3510 T3478 nsubj autoimmunity,persists
R939 T3511 T3510 prep in,autoimmunity
R940 T3512 T3513 nmod Apcs,mice
R941 T3513 T3511 pobj mice,in
R942 T3562 T3563 det a,region
R943 T3514 T3512 punct −,Apcs
R944 T3515 T3512 punct /,Apcs
R945 T3516 T3512 punct −,Apcs
R946 T3563 T3561 pobj region,within
R947 T3517 T3518 advmod even,after
R948 T3518 T3478 prep after,persists
R949 T3519 T3518 pcomp backcrossing,after
R950 T3520 T3521 det the,gene
R951 T3564 T3565 advmod where,mapped
R952 T3521 T3519 dobj gene,backcrossing
R953 T3522 T3521 amod mutated,gene
R954 T3565 T3563 relcl mapped,region
R955 T3523 T3519 prep onto,backcrossing
R956 T3524 T3523 pobj C57BL,onto
R957 T3525 T3524 punct /,C57BL
R958 T3526 T3524 nummod 6,C57BL
R959 T3527 T3528 punct (,Bickerstaff
R960 T3566 T3567 amod several,loci
R961 T3528 T3519 meta Bickerstaff,backcrossing
R962 T3529 T3528 nmod et,Bickerstaff
R963 T3530 T3528 nmod al.,Bickerstaff
R964 T3567 T3565 nsubjpass loci,mapped
R965 T3531 T3528 nummod 1999,Bickerstaff
R966 T3532 T3528 punct ),Bickerstaff
R967 T3533 T3478 punct .,persists
R968 T3568 T3569 compound lupus,susceptibility
R969 T3535 T3536 nsubj We,chose
R970 T3569 T3567 compound susceptibility,loci
R971 T3537 T3538 det this,gene
R972 T3538 T3536 dobj gene,chose
R973 T3570 T3569 punct -,susceptibility
R974 T3539 T3538 amod targeted,gene
R975 T3540 T3536 prep in,chose
R976 T3541 T3540 amod particular,in
R977 T3571 T3567 punct ", ",loci
R978 T3542 T3543 aux to,study
R979 T3543 T3536 advcl study,chose
R980 T3544 T3545 mark since,located
R981 T3572 T3567 acl designated,loci
R982 T3545 T3536 advcl located,chose
R983 T3546 T3547 det the,gene
R984 T3573 T3572 oprd Sle1,designated
R985 T3547 T3545 nsubjpass gene,located
R986 T3548 T3547 compound Apcs,gene
R987 T3549 T3545 auxpass is,located
R988 T3574 T3575 punct (,Morel
R989 T3550 T3545 prep on,located
R990 T3551 T3550 pobj Chromosome,on
R991 T3552 T3551 nummod 1,Chromosome
R992 T3553 T3551 punct ", ",Chromosome
R993 T3554 T3555 advmod approximately,94
R994 T3575 T3573 meta Morel,Sle1
R995 T3555 T3556 nummod 94,cM
R996 T3556 T3557 npadvmod cM,from
R997 T3557 T3551 prep from,Chromosome
R998 T3576 T3575 nmod et,Morel
R999 T3558 T3559 det the,centromere
R1000 T3559 T3557 pobj centromere,from
R1001 T3577 T3575 nmod al.,Morel
R1002 T3578 T3575 nummod 2001,Morel
R1003 T3579 T3575 punct ),Morel
R1004 T3580 T3573 punct ", ",Sle1
R1005 T3665 T3663 punct ;,Ravetch
R1006 T3666 T3663 conj Miwa,Ravetch
R1007 T3581 T3573 conj Nba2,Sle1
R1008 T3667 T3666 nmod et,Miwa
R1009 T3582 T3583 punct (,Drake
R1010 T3668 T3666 nmod al.,Miwa
R1011 T3669 T3666 nummod 2002,Miwa
R1012 T3670 T3666 punct ;,Miwa
R1013 T3583 T3581 meta Drake,Nba2
R1014 T3671 T3666 conj Wu,Miwa
R1015 T3672 T3671 nmod et,Wu
R1016 T3584 T3583 nmod et,Drake
R1017 T3673 T3671 nmod al.,Wu
R1018 T3674 T3671 nummod 2002,Wu
R1019 T3675 T3671 punct ),Wu
R1020 T3585 T3583 nmod al.,Drake
R1021 T3676 T3637 punct ", ",receptor
R1022 T3677 T3678 dep which,implicated
R1023 T3586 T3583 nummod 1995,Drake
R1024 T3678 T3637 relcl implicated,receptor
R1025 T3679 T3678 aux have,implicated
R1026 T3680 T3678 npadvmod each,implicated
R1027 T3681 T3678 auxpass been,implicated
R1028 T3587 T3583 punct ;,Drake
R1029 T3682 T3678 prep in,implicated
R1030 T3683 T3684 det the,causation
R1031 T3588 T3583 nmod Vyse,Drake
R1032 T3684 T3682 pobj causation,in
R1033 T3685 T3684 prep of,causation
R1034 T3686 T3685 pobj SLE,of
R1035 T3589 T3583 nmod et,Drake
R1036 T3687 T3688 advmod when,inactivated
R1037 T3688 T3678 advcl inactivated,implicated
R1038 T3689 T3688 prep by,inactivated
R1039 T3590 T3583 nmod al.,Drake
R1040 T3690 T3689 pobj gene,by
R1041 T3691 T3690 punct -,gene
R1042 T3692 T3690 amod targeting,gene
R1043 T3693 T3688 prep in,inactivated
R1044 T3694 T3695 nummod 129,cells
R1045 T3591 T3583 nummod 1997,Drake
R1046 T3695 T3693 pobj cells,in
R1047 T3696 T3695 amod embryonic,cells
R1048 T3697 T3695 compound stem,cells
R1049 T3698 T3627 punct .,contains
R1050 T3592 T3583 punct ),Drake
R1051 T3593 T3581 punct ", ",Nba2
R1052 T3700 T3701 advmod Here,show
R1053 T3702 T3701 nsubj we,show
R1054 T3594 T3581 cc and,Nba2
R1055 T3703 T3704 mark that,are
R1056 T3704 T3701 ccomp are,show
R1057 T3705 T3704 expl there,are
R1058 T3595 T3581 conj Bxs3,Nba2
R1059 T3706 T3707 amod multiple,loci
R1060 T3707 T3704 attr loci,are
R1061 T3708 T3707 amod genetic,loci
R1062 T3596 T3597 punct (,Hogarth
R1063 T3709 T3707 punct ", ",loci
R1064 T3710 T3707 acl derived,loci
R1065 T3711 T3710 prep from,derived
R1066 T3597 T3595 meta Hogarth,Bxs3
R1067 T3712 T3713 preconj both,129
R1068 T3713 T3714 nummod 129,mice
R1069 T3714 T3711 pobj mice,from
R1070 T3598 T3597 nmod et,Hogarth
R1071 T3715 T3713 cc and,129
R1072 T3716 T3713 conj C57BL,129
R1073 T3717 T3716 punct /,C57BL
R1074 T3599 T3597 nmod al.,Hogarth
R1075 T3718 T3716 nummod 6,C57BL
R1076 T3719 T3707 punct ", ",loci
R1077 T3720 T3707 acl contributing,loci
R1078 T3600 T3597 nummod 1998,Hogarth
R1079 T3721 T3720 prep to,contributing
R1080 T3722 T3721 pobj autoimmunity,to
R1081 T3601 T3597 punct ;,Hogarth
R1082 T3723 T3701 punct .,show
R1083 T3725 T3726 advmod Furthermore,was
R1084 T3602 T3597 nmod Haywood,Hogarth
R1085 T3727 T3726 punct ", ",was
R1086 T3728 T3729 det a,interval
R1087 T3603 T3597 nmod et,Hogarth
R1088 T3729 T3726 nsubj interval,was
R1089 T3730 T3731 advmod 129,derived
R1090 T3604 T3597 nmod al.,Hogarth
R1091 T3731 T3729 amod derived,interval
R1092 T3732 T3731 punct -,derived
R1093 T3733 T3729 prep on,interval
R1094 T3734 T3735 amod distal,Chromosome
R1095 T3735 T3733 pobj Chromosome,on
R1096 T3736 T3735 nummod 1,Chromosome
R1097 T3605 T3597 nummod 2000,Hogarth
R1098 T3737 T3726 punct ", ",was
R1099 T3738 T3739 advmod when,transferred
R1100 T3739 T3726 advcl transferred,was
R1101 T3606 T3597 punct ),Hogarth
R1102 T3740 T3739 prep onto,transferred
R1103 T3741 T3742 det the,genome
R1104 T3607 T3565 punct ", ",mapped
R1105 T3608 T3565 aux have,mapped
R1106 T3742 T3740 pobj genome,onto
R1107 T3609 T3565 auxpass been,mapped
R1108 T3743 T3742 nmod C57BL,genome
R1109 T3744 T3743 punct /,C57BL
R1110 T3610 T3565 prep in,mapped
R1111 T3745 T3743 nummod 6,C57BL
R1112 T3746 T3742 punct ", ",genome
R1113 T3747 T3748 det a,combination
R1114 T3611 T3612 nmod NZW,strains
R1115 T3748 T3742 appos combination,genome
R1116 T3749 T3750 advmod commonly,created
R1117 T3750 T3748 acl created,combination
R1118 T3612 T3610 pobj strains,in
R1119 T3751 T3750 prep by,created
R1120 T3613 T3611 punct ", ",NZW
R1121 T3752 T3751 pcomp backcrossing,by
R1122 T3753 T3752 prep onto,backcrossing
R1123 T3754 T3753 pobj C57BL,onto
R1124 T3614 T3611 conj NZB,NZW
R1125 T3755 T3754 punct /,C57BL
R1126 T3756 T3754 nummod 6,C57BL
R1127 T3757 T3758 det a,gene
R1128 T3615 T3614 punct ", ",NZB
R1129 T3758 T3752 dobj gene,backcrossing
R1130 T3759 T3760 dep that,inactivated
R1131 T3616 T3614 cc and,NZB
R1132 T3760 T3758 relcl inactivated,gene
R1133 T3761 T3760 aux has,inactivated
R1134 T3762 T3760 auxpass been,inactivated
R1135 T3617 T3614 conj BXSB,NZB
R1136 T3763 T3760 prep in,inactivated
R1137 T3764 T3765 nummod 129,cells
R1138 T3765 T3763 pobj cells,in
R1139 T3618 T3619 npadvmod lupus,prone
R1140 T3766 T3765 amod embryonic,cells
R1141 T3767 T3765 compound stem,cells
R1142 T3768 T3726 punct ", ",was
R1143 T3619 T3612 amod prone,strains
R1144 T3769 T3726 acomp sufficient,was
R1145 T3770 T3771 aux to,cause
R1146 T3620 T3619 punct -,prone
R1147 T3771 T3769 xcomp cause,sufficient
R1148 T3772 T3773 amod humoral,autoimmunity
R1149 T3621 T3565 punct ", ",mapped
R1150 T3773 T3771 dobj autoimmunity,cause
R1151 T3774 T3771 prep in,cause
R1152 T3622 T3565 advmod respectively,mapped
R1153 T3775 T3776 poss its,right
R1154 T3776 T3774 pobj right,in
R1155 T3777 T3776 amod own,right
R1156 T3623 T3536 punct .,chose
R1157 T3778 T3771 punct ", ",cause
R1158 T3779 T3771 advmod irrespective,cause
R1159 T3780 T3779 prep of,irrespective
R1160 T3625 T3626 det This,region
R1161 T3781 T3782 det the,presence
R1162 T3782 T3780 pobj presence,of
R1163 T3783 T3782 prep of,presence
R1164 T3626 T3627 nsubj region,contains
R1165 T3784 T3785 det the,gene
R1166 T3785 T3783 pobj gene,of
R1167 T3786 T3785 amod mutated,gene
R1168 T3628 T3629 amod several,genes
R1169 T3787 T3785 compound Apcs,gene
R1170 T3788 T3726 punct .,was
R1171 T3790 T3791 det These,results
R1172 T3629 T3627 dobj genes,contains
R1173 T3791 T3792 nsubj results,demonstrate
R1174 T3630 T3629 punct ", ",genes
R1175 T3793 T3794 amod important,interactions
R1176 T3794 T3792 dobj interactions,demonstrate
R1177 T3795 T3794 amod epistatic,interactions
R1178 T3631 T3629 prep including,genes
R1179 T3796 T3794 prep between,interactions
R1180 T3797 T3796 pobj genes,between
R1181 T3798 T3797 prep from,genes
R1182 T3632 T3631 pobj those,including
R1183 T3799 T3800 nummod 129,genomes
R1184 T3800 T3798 pobj genomes,from
R1185 T3633 T3632 acl encoding,those
R1186 T3801 T3799 cc and,129
R1187 T3802 T3799 conj C57BL,129
R1188 T3803 T3802 punct /,C57BL
R1189 T3634 T3633 dobj FcγRII,encoding
R1190 T3804 T3802 nummod 6,C57BL
R1191 T3805 T3794 prep on,interactions
R1192 T3806 T3807 det the,development
R1193 T3807 T3805 pobj development,on
R1194 T3635 T3632 punct ", ",those
R1195 T3808 T3807 prep of,development
R1196 T3809 T3808 pobj autoimmunity,of
R1197 T3636 T3637 det the,receptor
R1198 T3810 T3792 cc and,demonstrate
R1199 T3811 T3792 conj illustrate,demonstrate
R1200 T3812 T3813 det the,effects
R1201 T3813 T3811 dobj effects,illustrate
R1202 T3814 T3813 amod important,effects
R1203 T3815 T3813 prep of,effects
R1204 T3637 T3632 appos receptor,those
R1205 T3816 T3817 compound background,genes
R1206 T3817 T3815 pobj genes,of
R1207 T3818 T3811 prep in,illustrate
R1208 T3819 T3820 det the,analysis
R1209 T3638 T3637 compound complement,receptor
R1210 T3820 T3818 pobj analysis,in
R1211 T3821 T3820 cc and,analysis
R1212 T3822 T3820 conj interpretation,analysis
R1213 T3639 T3637 appos CR1,receptor
R1214 T3823 T3820 prep of,analysis
R1215 T3824 T3825 amod autoimmune,phenotypes
R1216 T3640 T3639 punct /,CR1
R1217 T3825 T3823 pobj phenotypes,of
R1218 T3641 T3639 nummod 2,CR1
R1219 T3826 T3825 acl associated,phenotypes
R1220 T3642 T3639 punct (,CR1
R1221 T3827 T3826 prep with,associated
R1222 T3828 T3829 amod targeted,disruptions
R1223 T3643 T3644 compound CD35,CD21
R1224 T3829 T3827 pobj disruptions,with
R1225 T3644 T3639 appos CD21,CR1
R1226 T3830 T3829 amod genetic,disruptions
R1227 T3831 T3792 punct .,demonstrate
R1228 T3645 T3644 punct /,CD21
R1229 T3646 T3639 punct ),CR1
R1230 T3647 T3637 punct ", ",receptor
R1231 T3648 T3637 cc and,receptor
R1232 T3649 T3650 det the,CD55
R1233 T3650 T3637 conj CD55,receptor
R1234 T3651 T3652 npadvmod decay,accelerating
R1235 T3652 T3650 amod accelerating,CD55
R1236 T3653 T3652 punct -,accelerating
R1237 T3654 T3650 compound factor,CD55
R1238 T3655 T3656 punct (,Prodeus
R1239 T3656 T3650 meta Prodeus,CD55
R1240 T3657 T3656 nmod et,Prodeus
R1241 T3658 T3656 nmod al.,Prodeus
R1242 T3659 T3656 nummod 1998,Prodeus
R1243 T3660 T3656 punct ;,Prodeus
R1244 T3661 T3656 conj Bolland,Prodeus
R1245 T3662 T3661 cc and,Bolland
R1246 T3663 T3661 conj Ravetch,Bolland
R1247 T3664 T3663 nummod 2000,Ravetch
R1248 T4464 T4465 compound Disease,Traits
R1249 T4466 T4465 prep in,Traits
R1250 T4467 T4468 punct (,Mice
R1251 T4468 T4466 pobj Mice,in
R1252 T4469 T4470 nummod 129,F2
R1253 T4470 T4468 nmod F2,Mice
R1254 T4471 T4469 punct ×,129
R1255 T4472 T4469 appos C57BL,129
R1256 T4473 T4472 punct /,C57BL
R1257 T4474 T4472 nummod 6,C57BL
R1258 T4475 T4470 punct ),F2
R1259 T4476 T4470 cc and,F2
R1260 T4477 T4478 punct (,F2
R1262 T4479 T4478 nummod 129,F2
R1263 T4480 T4479 punct ×,129
R1264 T4481 T4479 appos C57BL,129
R1265 T4482 T4481 punct /,C57BL
R1266 T4483 T4481 nummod 6,C57BL
R1267 T4484 T4478 punct ),F2
R1268 T4485 T4468 punct .,Mice
R1269 T4486 T4468 nmod Apcs,Mice
R1270 T4487 T4486 punct −,Apcs
R1271 T4488 T4486 punct /,Apcs
R1272 T4489 T4486 punct −,Apcs
R1273 T4491 T4492 aux To,investigate
R1274 T4492 T4493 advcl investigate,generated
R1275 T4494 T4495 det the,basis
R1276 T4495 T4492 dobj basis,investigate
R1277 T4496 T4495 amod genetic,basis
R1278 T4497 T4495 prep of,basis
R1279 T4498 T4499 det the,disease
R1280 T4499 T4497 pobj disease,of
R1281 T4500 T4501 npadvmod lupus,like
R1282 T4501 T4499 amod like,disease
R1283 T4502 T4501 punct -,like
R1284 T4503 T4499 acl observed,disease
R1285 T4504 T4503 prep in,observed
R1286 T4505 T4506 det the,mice
R1287 T4506 T4504 pobj mice,in
R1288 T4507 T4506 punct (,mice
R1289 T4508 T4506 nummod 129,mice
R1290 T4509 T4508 punct ×,129
R1291 T4510 T4508 appos C57BL,129
R1292 T4511 T4510 punct /,C57BL
R1293 T4512 T4510 nummod 6,C57BL
R1294 T4513 T4506 punct ),mice
R1295 T4514 T4506 compound hybrid,mice
R1296 T4515 T4493 punct ", ",generated
R1297 T4516 T4493 nsubj we,generated
R1298 T4517 T4518 nummod two,cohorts
R1299 T4518 T4493 dobj cohorts,generated
R1300 T4519 T4518 amod large,cohorts
R1301 T4520 T4518 prep of,cohorts
R1302 T4521 T4522 punct (,F2
R1303 T4522 T4529 compound F2,animals
R1304 T4523 T4522 nummod 129,F2
R1305 T4524 T4523 punct ×,129
R1306 T4525 T4523 appos C57BL,129
R1307 T4526 T4525 punct /,C57BL
R1308 T4527 T4525 nummod 6,C57BL
R1309 T4528 T4522 punct ),F2
R1310 T4529 T4520 pobj animals,of
R1311 T4530 T4518 punct ", ",cohorts
R1312 T4531 T4518 appos one,cohorts
R1313 T4532 T4531 acl carrying,one
R1314 T4533 T4534 det a,mutation
R1315 T4534 T4532 dobj mutation,carrying
R1316 T4535 T4532 prep in,carrying
R1317 T4536 T4537 det the,gene
R1318 T4537 T4535 pobj gene,in
R1319 T4538 T4537 compound Apcs,gene
R1320 T4539 T4493 punct ", ",generated
R1321 T4540 T4493 cc and,generated
R1322 T4541 T4493 conj monitored,generated
R1323 T4542 T4541 dobj them,monitored
R1324 T4543 T4541 prep for,monitored
R1325 T4544 T4545 nummod 1,y
R1326 T4545 T4543 pobj y,for
R1327 T4546 T4541 prep under,monitored
R1328 T4547 T4548 amod identical,conditions
R1329 T4548 T4546 pobj conditions,under
R1330 T4549 T4548 amod environmental,conditions
R1331 T4550 T4493 punct .,generated
R1332 T4552 T4553 mark Since,showed
R1333 T4553 T4560 advcl showed,conducted
R1334 T4554 T4555 amod female,mice
R1335 T4555 T4553 nsubj mice,showed
R1336 T4556 T4553 prep in,showed
R1337 T4557 T4558 det the,reports
R1338 T4558 T4556 pobj reports,in
R1339 T4559 T4558 amod original,reports
R1340 T4561 T4562 det a,penetrance
R1341 T4562 T4553 dobj penetrance,showed
R1342 T4563 T4562 amod higher,penetrance
R1343 T4564 T4562 prep of,penetrance
R1344 T4565 T4564 pobj disease,of
R1345 T4566 T4560 punct ", ",conducted
R1346 T4567 T4568 det the,study
R1347 T4568 T4560 nsubjpass study,conducted
R1348 T4569 T4568 amod present,study
R1349 T4570 T4560 auxpass was,conducted
R1350 T4571 T4560 advmod only,conducted
R1351 T4572 T4560 prep on,conducted
R1352 T4573 T4574 amod female,mice
R1353 T4574 T4572 pobj mice,on
R1354 T4575 T4560 punct .,conducted
R1355 T4577 T4578 det The,results
R1356 T4578 T4579 nsubjpass results,summarised
R1357 T4580 T4578 prep of,results
R1358 T4581 T4582 det the,analysis
R1359 T4582 T4580 pobj analysis,of
R1360 T4583 T4582 amod phenotypic,analysis
R1361 T4584 T4578 prep at,results
R1362 T4585 T4586 nummod 1,y
R1363 T4586 T4584 pobj y,at
R1364 T4587 T4586 prep of,y
R1365 T4588 T4587 pobj age,of
R1366 T4589 T4579 auxpass are,summarised
R1367 T4590 T4579 prep in,summarised
R1368 T4591 T4592 nmod Tables,1
R1369 T4592 T4590 pobj 1,in
R1370 T4593 T4592 cc and,1
R1371 T4594 T4592 conj 2,1
R1372 T4595 T4579 punct .,summarised
R1373 T4597 T4598 mark As,reported
R1374 T4598 T4600 advcl reported,developed
R1375 T4599 T4598 advmod previously,reported
R1376 T4601 T4602 punct (,Botto
R1377 T4602 T4598 meta Botto,reported
R1378 T4603 T4602 nmod et,Botto
R1379 T4604 T4602 nmod al.,Botto
R1380 T4605 T4602 nummod 1998,Botto
R1381 T4606 T4602 punct ),Botto
R1382 T4607 T4600 punct ", ",developed
R1383 T4608 T4609 det the,mice
R1384 T4609 T4600 nsubj mice,developed
R1385 T4610 T4611 amod wild,type
R1386 T4611 T4609 nmod type,mice
R1387 T4612 T4611 punct -,type
R1388 T4613 T4609 punct (,mice
R1389 T4614 T4609 nummod 129,mice
R1390 T4615 T4614 punct ×,129
R1391 T4616 T4614 appos C57BL,129
R1392 T4617 T4616 punct /,C57BL
R1393 T4618 T4616 nummod 6,C57BL
R1394 T4619 T4609 punct ),mice
R1395 T4620 T4609 compound F2,mice
R1396 T4621 T4622 compound lupus,traits
R1397 T4622 T4600 dobj traits,developed
R1398 T4623 T4622 prep with,traits
R1399 T4624 T4625 amod elevated,levels
R1400 T4625 T4623 pobj levels,with
R1401 T4626 T4625 prep of,levels
R1402 T4627 T4626 pobj auto-Abs,of
R1403 T4628 T4625 punct ", ",levels
R1404 T4629 T4625 acl starting,levels
R1405 T4630 T4629 prep from,starting
R1406 T4631 T4632 nummod 6,mo
R1407 T4632 T4630 pobj mo,from
R1408 T4633 T4632 prep of,mo
R1409 T4634 T4633 pobj age,of
R1410 T4635 T4636 punct (,shown
R1411 T4636 T4629 parataxis shown,starting
R1412 T4637 T4636 nsubj data,shown
R1413 T4638 T4636 neg not,shown
R1414 T4639 T4636 punct ),shown
R1415 T4640 T4622 punct ", ",traits
R1416 T4641 T4622 cc and,traits
R1417 T4642 T4643 amod histological,evidence
R1418 T4643 T4622 conj evidence,traits
R1419 T4644 T4643 prep of,evidence
R1420 T4645 T4646 amod proliferative,glomerulonephritis
R1421 T4646 T4644 pobj glomerulonephritis,of
R1422 T4647 T4600 punct .,developed
R1423 T4649 T4650 prep In,were
R1424 T4651 T4649 pobj agreement,In
R1425 T4652 T4651 prep with,agreement
R1426 T4653 T4654 poss our,observations
R1427 T4654 T4652 pobj observations,with
R1428 T4655 T4654 amod previous,observations
R1429 T4656 T4657 punct (,Bickerstaff
R1430 T4657 T4654 meta Bickerstaff,observations
R1431 T4658 T4657 nmod et,Bickerstaff
R1432 T4659 T4657 nmod al.,Bickerstaff
R1433 T4660 T4657 nummod 1999,Bickerstaff
R1434 T4661 T4657 punct ),Bickerstaff
R1435 T4662 T4650 punct ", ",were
R1436 T4663 T4664 det the,titres
R1437 T4664 T4650 nsubj titres,were
R1438 T4665 T4664 prep of,titres
R1439 T4666 T4667 amod anti-nuclear,Abs
R1440 T4667 T4665 pobj Abs,of
R1441 T4668 T4667 punct (,Abs
R1442 T4669 T4667 appos ANAs,Abs
R1443 T4670 T4667 punct ),Abs
R1444 T4671 T4667 cc and,Abs
R1445 T4672 T4673 amod anti-chromatin,Ab
R1446 T4673 T4667 conj Ab,Abs
R1447 T4674 T4675 advmod considerably,greater
R1448 T4675 T4650 acomp greater,were
R1449 T4676 T4650 prep in,were
R1450 T4677 T4678 det the,mice
R1451 T4678 T4676 pobj mice,in
R1452 T4679 T4678 punct (,mice
R1453 T4680 T4681 nummod 129,F2
R1454 T4681 T4678 nmod F2,mice
R1455 T4682 T4680 punct ×,129
R1456 T4683 T4680 appos C57BL,129
R1457 T4684 T4683 punct /,C57BL
R1458 T4685 T4683 nummod 6,C57BL
R1459 T4686 T4681 punct ),F2
R1460 T4687 T4681 punct .,F2
R1461 T4688 T4681 appos Apcs,F2
R1462 T4689 T4688 punct −,Apcs
R1463 T4690 T4688 punct /,Apcs
R1464 T4691 T4688 punct −,Apcs
R1465 T4692 T4650 prep compared,were
R1466 T4693 T4692 prep with,compared
R1467 T4694 T4695 det the,controls
R1468 T4695 T4693 pobj controls,with
R1469 T4696 T4697 npadvmod strain,matched
R1470 T4697 T4695 amod matched,controls
R1471 T4698 T4697 punct -,matched
R1472 T4699 T4650 punct .,were
R1473 T4701 T4702 advmod However,were
R1474 T4703 T4702 punct ", ",were
R1475 T4704 T4702 prep in,were
R1476 T4705 T4704 pobj contrast,in
R1477 T4706 T4705 prep to,contrast
R1478 T4707 T4708 poss our,findings
R1479 T4708 T4706 pobj findings,to
R1480 T4709 T4708 amod original,findings
R1481 T4710 T4702 punct ", ",were
R1482 T4711 T4712 det the,levels
R1483 T4712 T4702 nsubj levels,were
R1484 T4713 T4712 prep of,levels
R1485 T4714 T4715 det the,markers
R1486 T4715 T4713 pobj markers,of
R1487 T4716 T4715 amod other,markers
R1488 T4717 T4715 nummod two,markers
R1489 T4718 T4715 nmod disease,markers
R1490 T4719 T4715 amod serological,markers
R1491 T4720 T4715 acl analysed,markers
R1492 T4721 T4722 punct (,Abs
R1493 T4722 T4715 parataxis Abs,markers
R1494 T4723 T4724 advmod anti-single,stranded
R1495 T4724 T4726 amod stranded,DNA
R1496 T4725 T4724 punct -,stranded
R1497 T4726 T4722 nmod DNA,Abs
R1498 T4727 T4726 punct [,DNA
R1499 T4728 T4726 appos ssDNA,DNA
R1500 T4729 T4726 punct ],DNA
R1501 T4730 T4726 cc and,DNA
R1502 T4731 T4732 advmod anti-double,stranded
R1503 T4732 T4734 amod stranded,DNA
R1504 T4733 T4732 punct -,stranded
R1505 T4734 T4726 conj DNA,DNA
R1506 T4735 T4734 punct [,DNA
R1507 T4736 T4734 appos dsDNA,DNA
R1508 T4737 T4734 punct ],DNA
R1509 T4738 T4722 punct ),Abs
R1510 T4739 T4712 cc and,levels
R1511 T4740 T4741 det the,severity
R1512 T4741 T4712 conj severity,levels
R1513 T4742 T4741 prep of,severity
R1514 T4743 T4744 det the,pathology
R1515 T4744 T4742 pobj pathology,of
R1516 T4745 T4744 amod renal,pathology
R1517 T4746 T4702 neg not,were
R1518 T4747 T4702 acomp different,were
R1519 T4748 T4702 prep between,were
R1520 T4749 T4750 det the,groups
R1521 T4750 T4748 pobj groups,between
R1522 T4751 T4750 nummod two,groups
R1523 T4752 T4750 amod experimental,groups
R1524 T4753 T4702 punct .,were
R1525 T4755 T4756 prep In,carried
R1526 T4757 T4755 pobj view,In
R1527 T4758 T4757 prep of,view
R1528 T4759 T4760 det the,possibility
R1529 T4760 T4758 pobj possibility,of
R1530 T4761 T4760 prep of,possibility
R1531 T4762 T4763 det an,association
R1532 T4763 T4761 pobj association,of
R1533 T4764 T4763 prep between,association
R1534 T4765 T4766 det the,segment
R1535 T4766 T4764 pobj segment,between
R1536 T4767 T4766 amod fixed,segment
R1537 T4768 T4769 advmod 129,derived
R1538 T4769 T4766 amod derived,segment
R1539 T4770 T4769 punct -,derived
R1540 T4771 T4766 acl flanking,segment
R1541 T4772 T4773 det the,gene
R1542 T4773 T4771 dobj gene,flanking
R1543 T4774 T4773 amod mutated,gene
R1544 T4775 T4773 compound Apcs,gene
R1545 T4776 T4766 cc and,segment
R1546 T4777 T4778 det the,traits
R1547 T4778 T4766 conj traits,segment
R1548 T4779 T4778 amod autoimmune,traits
R1549 T4780 T4778 acl observed,traits
R1550 T4781 T4756 punct ", ",carried
R1551 T4782 T4783 det the,analysis
R1552 T4783 T4756 nsubjpass analysis,carried
R1553 T4784 T4785 npadvmod genome,wide
R1554 T4785 T4783 amod wide,analysis
R1555 T4786 T4785 punct -,wide
R1556 T4787 T4783 compound linkage,analysis
R1557 T4788 T4783 prep of,analysis
R1558 T4789 T4790 det the,cohorts
R1559 T4790 T4788 pobj cohorts,of
R1560 T4791 T4790 nummod two,cohorts
R1561 T4792 T4790 amod experimental,cohorts
R1562 T4793 T4756 auxpass was,carried
R1563 T4794 T4756 prt out,carried
R1564 T4795 T4756 advmod separately,carried
R1565 T4796 T4756 punct .,carried
R1568 T6733 T6732 prep of,Mapping
R1569 T6734 T6733 pobj Loci,of
R1570 T6735 T6734 acl Predisposing,Loci
R1571 T6736 T6735 prep to,Predisposing
R1572 T6737 T6736 pobj Lupus,to
R1573 T6738 T6732 prep in,Mapping
R1574 T6739 T6740 det the,Strain
R1575 T6740 T6738 pobj Strain,in
R1576 T6741 T6740 compound Hybrid,Strain
R1577 T6742 T6740 punct (,Strain
R1578 T6743 T6740 appos 129,Strain
R1579 T6744 T6743 punct ×,129
R1580 T6745 T6743 appos C57BL,129
R1581 T6746 T6745 punct /,C57BL
R1582 T6747 T6745 nummod 6,C57BL
R1583 T6748 T6740 punct ),Strain
R1584 T6750 T6751 nsubjpass Mice,genotyped
R1585 T6752 T6751 auxpass were,genotyped
R1586 T6753 T6751 prep with,genotyped
R1587 T6754 T6755 nummod 143,markers
R1588 T6755 T6753 pobj markers,with
R1589 T6756 T6755 compound microsatellite,markers
R1590 T6757 T6755 acl distributed,markers
R1591 T6758 T6757 prep throughout,distributed
R1592 T6759 T6760 det the,autosomes
R1593 T6760 T6758 pobj autosomes,throughout
R1594 T6761 T6762 amod such,were
R1595 T6762 T6751 advcl were,genotyped
R1596 T6763 T6762 mark that,were
R1597 T6764 T6765 nummod 98,%
R1598 T6765 T6762 nsubj %,were
R1599 T6766 T6765 prep of,%
R1600 T6767 T6768 det the,genes
R1601 T6768 T6766 pobj genes,of
R1602 T6769 T6762 prep within,were
R1603 T6770 T6771 nummod 20,cM
R1604 T6771 T6769 pobj cM,within
R1605 T6772 T6771 prep of,cM
R1606 T6773 T6774 det an,marker
R1607 T6774 T6772 pobj marker,of
R1608 T6775 T6774 amod informative,marker
R1609 T6776 T6751 punct .,genotyped
R1610 T6778 T6779 det A,summary
R1611 T6779 T6780 nsubjpass summary,shown
R1612 T6781 T6779 prep of,summary
R1613 T6782 T6783 det the,analysis
R1614 T6783 T6781 pobj analysis,of
R1615 T6784 T6785 npadvmod genome,wide
R1616 T6785 T6783 amod wide,analysis
R1617 T6786 T6785 punct -,wide
R1618 T6787 T6783 compound linkage,analysis
R1619 T6788 T6779 prep for,summary
R1620 T6789 T6788 pobj each,for
R1621 T6790 T6789 prep of,each
R1622 T6791 T6792 det the,traits
R1623 T6792 T6790 pobj traits,of
R1624 T6793 T6792 compound disease,traits
R1625 T6794 T6792 acl measured,traits
R1626 T6795 T6780 auxpass is,shown
R1627 T6796 T6780 prep in,shown
R1628 T6797 T6796 pobj Table,in
R1629 T6798 T6797 nummod 3,Table
R1630 T6799 T6780 punct .,shown
R1631 T6801 T6802 det The,areas
R1632 T6802 T6803 nsubjpass areas,defined
R1633 T6804 T6802 prep of,areas
R1634 T6805 T6804 pobj linkage,of
R1635 T6806 T6803 auxpass were,defined
R1636 T6807 T6803 prep according,defined
R1637 T6808 T6807 prep to,according
R1638 T6809 T6810 det the,origin
R1639 T6810 T6808 pobj origin,to
R1640 T6811 T6810 amod parental,origin
R1641 T6812 T6810 punct ", ",origin
R1642 T6813 T6810 appos 129,origin
R1643 T6814 T6813 cc or,129
R1644 T6815 T6813 conj C57BL,129
R1645 T6816 T6815 punct /,C57BL
R1646 T6817 T6815 nummod 6,C57BL
R1647 T6818 T6803 punct .,defined
R1648 T6820 T6821 advmod Only,linkages
R1649 T6821 T6822 nsubjpass linkages,reported
R1650 T6823 T6821 acl identified,linkages
R1651 T6824 T6823 prep in,identified
R1652 T6825 T6826 det both,groups
R1653 T6826 T6824 pobj groups,in
R1654 T6827 T6826 amod experimental,groups
R1655 T6828 T6822 auxpass are,reported
R1656 T6829 T6822 prep in,reported
R1657 T6830 T6829 pobj Table,in
R1658 T6831 T6830 nummod 3,Table
R1659 T6832 T6822 punct ", ",reported
R1660 T6833 T6822 prep with,reported
R1661 T6834 T6835 det the,exception
R1662 T6835 T6833 pobj exception,with
R1663 T6836 T6835 prep of,exception
R1664 T6837 T6838 det the,segment
R1665 T6838 T6836 pobj segment,of
R1666 T6839 T6838 nmod Chromosome,segment
R1667 T6840 T6839 nummod 1,Chromosome
R1668 T6841 T6838 amod distal,segment
R1669 T6842 T6838 punct ", ",segment
R1670 T6843 T6844 advmod where,applied
R1671 T6844 T6838 relcl applied,segment
R1672 T6845 T6846 det the,analysis
R1673 T6846 T6844 nsubjpass analysis,applied
R1674 T6847 T6846 compound linkage,analysis
R1675 T6848 T6844 aux could,applied
R1676 T6849 T6844 neg not,applied
R1677 T6850 T6844 auxpass be,applied
R1678 T6851 T6844 prep to,applied
R1679 T6852 T6853 det the,mice
R1680 T6853 T6851 pobj mice,to
R1681 T6854 T6855 punct (,F2
R1682 T6855 T6853 nmod F2,mice
R1683 T6856 T6855 nummod 129,F2
R1684 T6857 T6856 punct ×,129
R1685 T6858 T6856 appos C57BL,129
R1686 T6859 T6858 punct /,C57BL
R1687 T6860 T6858 nummod 6,C57BL
R1688 T6861 T6855 punct ),F2
R1689 T6862 T6855 punct .,F2
R1690 T6863 T6855 appos Apcs,F2
R1691 T6864 T6863 punct −,Apcs
R1692 T6865 T6863 punct /,Apcs
R1693 T6866 T6863 punct −,Apcs
R1694 T6867 T6868 mark as,was
R1695 T6868 T6844 advcl was,applied
R1696 T6869 T6870 det this,region
R1697 T6870 T6868 nsubj region,was
R1698 T6871 T6868 prep of,was
R1699 T6872 T6873 amod fixed,origin
R1700 T6873 T6871 pobj origin,of
R1701 T6874 T6873 nummod 129,origin
R1702 T6875 T6822 punct .,reported
R1703 T6877 T6878 nsubjpass Chromosomes,shown
R1704 T6879 T6880 advmod where,were
R1705 T6880 T6877 relcl were,Chromosomes
R1706 T6881 T6880 nsubj linkages,were
R1707 T6882 T6880 acomp present,were
R1708 T6883 T6884 advmod only,in
R1709 T6884 T6880 prep in,were
R1710 T6885 T6884 pobj one,in
R1711 T6886 T6885 prep of,one
R1712 T6887 T6888 det the,cohorts
R1713 T6888 T6886 pobj cohorts,of
R1714 T6889 T6888 nummod two,cohorts
R1715 T6890 T6878 auxpass are,shown
R1716 T6891 T6878 prep in,shown
R1717 T6892 T6893 nmod Figures,1
R1718 T6893 T6891 pobj 1,in
R1719 T6894 T6895 punct –,3
R1720 T6895 T6893 prep 3,1
R1721 T6896 T6878 punct .,shown
R1722 T6898 T6899 det The,analysis
R1723 T6899 T6906 nsubj analysis,identified
R1724 T6900 T6901 amod quantitative,linkage
R1725 T6901 T6899 nmod linkage,analysis
R1726 T6902 T6901 nmod trait,linkage
R1727 T6903 T6901 punct (,linkage
R1728 T6904 T6901 appos QTL,linkage
R1729 T6905 T6901 punct ),linkage
R1730 T6907 T6908 amod several,intervals
R1731 T6908 T6906 dobj intervals,identified
R1732 T6909 T6908 prep on,intervals
R1733 T6910 T6909 pobj Chromosome,on
R1734 T6911 T6910 nummod 1,Chromosome
R1735 T6912 T6908 prep with,intervals
R1736 T6913 T6912 pobj linkage,with
R1737 T6914 T6913 prep to,linkage
R1738 T6915 T6916 nmod disease,markers
R1739 T6916 T6914 pobj markers,to
R1740 T6917 T6916 amod serological,markers
R1741 T6918 T6906 punct ", ",identified
R1742 T6919 T6906 cc and,identified
R1743 T6920 T6921 det these,regions
R1744 T6921 T6922 nsubjpass regions,derived
R1745 T6922 T6906 conj derived,identified
R1746 T6923 T6922 auxpass were,derived
R1747 T6924 T6922 advmod all,derived
R1748 T6925 T6922 prep from,derived
R1749 T6926 T6927 det the,strain
R1750 T6927 T6925 pobj strain,from
R1751 T6928 T6927 nummod 129,strain
R1752 T6929 T6927 compound mouse,strain
R1753 T6930 T6931 punct (,4
R1754 T6931 T6922 parataxis 4,derived
R1755 T6932 T6931 advcl see,4
R1756 T6933 T6932 dobj Table,see
R1757 T6934 T6933 nummod 3,Table
R1758 T6935 T6931 punct ;,4
R1759 T6936 T6931 nmod Figures,4
R1760 T6937 T6931 cc and,4
R1761 T6938 T6931 conj 5,4
R1762 T6939 T6931 punct ),4
R1763 T6940 T6922 punct .,derived
R1764 T6942 T6943 advmod Interestingly,linked
R1765 T6944 T6943 punct ", ",linked
R1766 T6945 T6946 mark whilst,showed
R1767 T6946 T6943 advcl showed,linked
R1768 T6947 T6948 nmod ANA,levels
R1769 T6948 T6946 nsubj levels,showed
R1770 T6949 T6947 cc and,ANA
R1771 T6950 T6951 amod anti-chromatin,Ab
R1772 T6951 T6947 conj Ab,ANA
R1773 T6952 T6953 amod suggestive,linkages
R1774 T6953 T6946 dobj linkages,showed
R1775 T6954 T6952 cc or,suggestive
R1776 T6955 T6952 conj significant,suggestive
R1777 T6956 T6957 advmod only,to
R1778 T6957 T6953 prep to,linkages
R1779 T6958 T6959 det the,region
R1780 T6959 T6957 pobj region,to
R1781 T6960 T6959 amod telomeric,region
R1782 T6961 T6959 prep of,region
R1783 T6962 T6961 pobj Chromosome,of
R1784 T6963 T6962 nummod 1,Chromosome
R1785 T6964 T6953 punct ", ",linkages
R1786 T6965 T6953 prep with,linkages
R1787 T6966 T6967 det an,peak
R1788 T6967 T6969 nsubj peak,occurring
R1789 T6968 T6967 amod estimated,peak
R1790 T6969 T6965 pcomp occurring,with
R1791 T6970 T6969 prep at,occurring
R1792 T6971 T6972 det a,position
R1793 T6972 T6970 pobj position,at
R1794 T6973 T6974 advmod approximately,90
R1795 T6974 T6975 nummod 90,cM
R1796 T6975 T6976 npadvmod cM,near
R1797 T6976 T6972 prep near,position
R1798 T6977 T6978 det the,gene
R1799 T6978 T6976 pobj gene,near
R1800 T6979 T6978 compound Apcs,gene
R1801 T6980 T6943 punct ", ",linked
R1802 T6981 T6982 amod anti-dsDNA,production
R1803 T6982 T6943 nsubjpass production,linked
R1804 T6983 T6981 cc or,anti-dsDNA
R1805 T6984 T6981 conj anti-ssDNA,anti-dsDNA
R1806 T6985 T6982 compound Ab,production
R1807 T6986 T6943 auxpass was,linked
R1808 T6987 T6943 advmod also,linked
R1809 T6988 T6943 prep to,linked
R1810 T6989 T6990 amod other,segments
R1811 T6990 T6988 pobj segments,to
R1812 T6991 T6990 prep on,segments
R1813 T6992 T6991 pobj Chromosome,on
R1814 T6993 T6992 nummod 1,Chromosome
R1815 T6994 T6943 punct ", ",linked
R1816 T6995 T6943 advcl indicating,linked
R1817 T6996 T6997 det a,contribution
R1818 T6997 T6995 dobj contribution,indicating
R1819 T6998 T6999 advmod more,complex
R1820 T6999 T6997 amod complex,contribution
R1821 T7000 T6997 amod genetic,contribution
R1822 T7001 T6995 prep from,indicating
R1823 T7002 T7003 det the,strain
R1824 T7003 T7001 pobj strain,from
R1825 T7004 T7003 nummod 129,strain
R1826 T7005 T7003 compound mouse,strain
R1827 T7006 T6943 punct .,linked
R1828 T7008 T7009 advcl Guided,investigated
R1829 T7010 T7008 agent by,Guided
R1830 T7011 T7012 det these,observations
R1831 T7012 T7010 pobj observations,by
R1832 T7013 T7009 punct ", ",investigated
R1833 T7014 T7009 nsubj we,investigated
R1834 T7015 T7016 mark whether,caused
R1835 T7016 T7009 ccomp caused,investigated
R1836 T7017 T7018 det the,levels
R1837 T7018 T7016 nsubjpass levels,caused
R1838 T7019 T7018 amod increased,levels
R1839 T7020 T7018 prep of,levels
R1840 T7021 T7020 pobj ANA,of
R1841 T7022 T7021 cc and,ANA
R1842 T7023 T7024 amod anti-chromatin,Ab
R1843 T7024 T7021 conj Ab,ANA
R1844 T7025 T7018 acl observed,levels
R1845 T7026 T7025 prep in,observed
R1846 T7027 T7028 det the,mice
R1847 T7028 T7026 pobj mice,in
R1848 T7029 T7028 nmod Apcs,mice
R1849 T7030 T7029 punct −,Apcs
R1850 T7031 T7029 punct /,Apcs
R1851 T7032 T7029 punct −,Apcs
R1852 T7033 T7016 auxpass were,caused
R1853 T7034 T7016 agent by,caused
R1854 T7035 T7036 det a,gene
R1855 T7036 T7034 pobj gene,by
R1856 T7037 T7036 punct (,gene
R1857 T7038 T7036 nmod s,gene
R1858 T7039 T7036 punct ),gene
R1859 T7040 T7036 prep within,gene
R1860 T7041 T7042 det the,region
R1861 T7042 T7040 pobj region,within
R1862 T7043 T7042 amod fixed,region
R1863 T7044 T7042 nummod 129,region
R1864 T7045 T7042 acl surrounding,region
R1865 T7046 T7047 det the,gene
R1866 T7047 T7045 dobj gene,surrounding
R1867 T7048 T7047 amod mutated,gene
R1868 T7049 T7047 compound Apcs,gene
R1869 T7050 T7016 punct ", ",caused
R1870 T7051 T7052 advmod rather,than
R1871 T7052 T7016 cc than,caused
R1872 T7053 T7016 conj caused,caused
R1873 T7054 T7053 agent by,caused
R1874 T7055 T7056 det the,gene
R1875 T7056 T7054 pobj gene,by
R1876 T7057 T7056 amod mutated,gene
R1877 T7058 T7056 compound Apcs,gene
R1878 T7059 T7056 appos itself,gene
R1879 T7060 T7009 punct .,investigated
R1880 T7062 T7063 nsubj We,compared
R1881 T7064 T7065 det the,levels
R1882 T7065 T7063 dobj levels,compared
R1883 T7066 T7065 prep of,levels
R1884 T7067 T7068 det these,auto-Abs
R1885 T7068 T7066 pobj auto-Abs,of
R1886 T7069 T7065 prep between,levels
R1887 T7070 T7071 det all,mice
R1888 T7071 T7069 pobj mice,between
R1889 T7072 T7071 punct (,mice
R1890 T7073 T7074 nummod 129,F2
R1891 T7074 T7071 nmod F2,mice
R1892 T7075 T7073 punct ×,129
R1893 T7076 T7073 appos C57BL,129
R1894 T7077 T7076 punct /,C57BL
R1895 T7078 T7076 nummod 6,C57BL
R1896 T7079 T7074 punct ),F2
R1897 T7080 T7074 punct .,F2
R1898 T7081 T7074 appos Apcs,F2
R1899 T7082 T7081 punct −,Apcs
R1900 T7083 T7081 punct /,Apcs
R1901 T7084 T7081 punct −,Apcs
R1902 T7085 T7071 cc and,mice
R1903 T7086 T7087 det a,group
R1904 T7087 T7071 conj group,mice
R1905 T7088 T7087 prep of,group
R1906 T7089 T7090 nummod 33,mice
R1907 T7090 T7088 pobj mice,of
R1908 T7091 T7092 amod wild,type
R1909 T7092 T7090 compound type,mice
R1910 T7093 T7092 punct -,type
R1911 T7094 T7095 dep that,selected
R1912 T7095 T7090 relcl selected,mice
R1913 T7096 T7095 auxpass were,selected
R1914 T7097 T7095 prep for,selected
R1915 T7098 T7097 pcomp being,for
R1916 T7099 T7100 amod homozygous,129
R1917 T7100 T7098 attr 129,being
R1918 T7101 T7098 prep in,being
R1919 T7102 T7103 det the,region
R1920 T7209 T7212 dep mg,16
R1921 T7210 T7209 punct ", ",mg
R1922 T7211 T7209 nummod 83,mg
R1923 T7212 T7207 dep 16,0.0001
R1924 T7213 T7214 punct /,l
R1925 T7214 T7209 prep l,mg
R1926 T7215 T7212 punct ;,16
R1927 T7216 T7217 dep range,25
R1928 T7217 T7212 dep 25,16
R1929 T7218 T7217 punct ", ",25
R1930 T7219 T7220 punct –,208
R1931 T7220 T7217 prep 208,25
R1932 T7221 T7212 punct ;,16
R1933 T7222 T7212 nsubj n,16
R1934 T7223 T7212 punct =,16
R1935 T7224 T7212 cc versus,16
R1936 T7225 T7226 dep median,mg
R1937 T7226 T7229 dep mg,10
R1938 T7227 T7226 punct ", ",mg
R1939 T7228 T7226 nummod 5,mg
R1940 T7103 T7101 pobj region,in
R1941 T7229 T7241 dep 10,respectively
R1942 T7104 T7103 prep of,region
R1943 T7230 T7231 punct /,l
R1944 T7105 T7104 pobj Chromosome,of
R1945 T7106 T7105 nummod 1,Chromosome
R1946 T7231 T7226 prep l,mg
R1947 T7107 T7103 prep between,region
R1948 T7108 T7109 compound microsatellites,D1Mit105
R1949 T7109 T7107 pobj D1Mit105,between
R1950 T7232 T7229 punct ;,10
R1951 T7110 T7109 cc and,D1Mit105
R1952 T7111 T7109 conj D1Mit,D1Mit105
R1953 T7233 T7234 dep range,4
R1954 T7112 T7111 nummod 223,D1Mit
R1955 T7113 T7114 punct (,cM
R1956 T7234 T7229 dep 4,10
R1957 T7114 T7103 parataxis cM,region
R1958 T7115 T7116 quantmod 80,106
R1959 T7116 T7114 nummod 106,cM
R1960 T7235 T7234 punct ", ",4
R1961 T7117 T7116 punct –,106
R1962 T7118 T7114 punct ),cM
R1963 T7119 T7120 punct (,6A
R1964 T7236 T7237 punct –,9
R1965 T7120 T7063 parataxis 6A,compared
R1966 T7121 T7120 compound Figure,6A
R1967 T7237 T7234 prep 9,4
R1968 T7122 T7123 punct –,6D
R1969 T7123 T7120 prep 6D,6A
R1970 T7124 T7120 punct ),6A
R1971 T7238 T7229 punct ;,10
R1972 T7125 T7063 punct .,compared
R1973 T7239 T7229 nsubj n,10
R1974 T7127 T7128 prep In,showed
R1975 T7240 T7229 punct =,10
R1976 T7129 T7127 pobj contrast,In
R1977 T7130 T7129 prep to,contrast
R1978 T7131 T7132 det the,results
R1979 T7241 T7212 conj respectively,16
R1980 T7132 T7130 pobj results,to
R1981 T7133 T7132 acl reported,results
R1982 T7134 T7133 prep in,reported
R1983 T7242 T7229 punct ", ",10
R1984 T7135 T7134 pobj Table,in
R1985 T7136 T7135 nummod 1,Table
R1986 T7137 T7128 punct ", ",showed
R1987 T7138 T7139 det this,comparison
R1988 T7243 T7207 punct ;,0.0001
R1989 T7244 T7207 nsubj p,0.0001
R1990 T7139 T7128 nsubj comparison,showed
R1991 T7140 T7141 det no,differences
R1992 T7245 T7207 punct <,0.0001
R1993 T7141 T7128 dobj differences,showed
R1994 T7142 T7141 amod significant,differences
R1995 T7246 T7207 punct ),0.0001
R1996 T7143 T7141 prep between,differences
R1997 T7144 T7145 det the,groups
R1998 T7247 T7181 punct .,found
R1999 T7145 T7143 pobj groups,between
R2000 T7146 T7145 nummod two,groups
R2001 T7147 T7145 amod experimental,groups
R2002 T7249 T7250 det The,strain
R2003 T7148 T7128 punct .,showed
R2004 T7150 T7151 det This,result
R2005 T7250 T7254 nsubjpass strain,reported
R2006 T7151 T7152 nsubj result,demonstrates
R2007 T7251 T7250 nmod C57BL,strain
R2008 T7153 T7154 mark that,mediating
R2009 T7154 T7152 ccomp mediating,demonstrates
R2010 T7252 T7251 punct /,C57BL
R2011 T7155 T7154 punct ", ",mediating
R2012 T7156 T7157 advmod most,likely
R2013 T7157 T7154 advmod likely,mediating
R2014 T7253 T7251 nummod 6,C57BL
R2015 T7158 T7154 punct ", ",mediating
R2016 T7159 T7160 det the,region
R2017 T7255 T7254 aux has,reported
R2018 T7160 T7154 nsubj region,mediating
R2019 T7161 T7162 advmod 129,derived
R2020 T7162 T7160 amod derived,region
R2021 T7163 T7162 punct -,derived
R2022 T7256 T7254 advmod previously,reported
R2023 T7164 T7160 cc and,region
R2024 T7165 T7164 neg not,and
R2025 T7166 T7167 det the,lack
R2026 T7257 T7254 auxpass been,reported
R2027 T7167 T7160 conj lack,region
R2028 T7168 T7167 prep of,lack
R2029 T7258 T7259 aux to,be
R2030 T7169 T7168 pobj Apcs,of
R2031 T7170 T7154 aux was,mediating
R2032 T7171 T7172 det the,production
R2033 T7172 T7154 dobj production,mediating
R2034 T7173 T7172 prep of,production
R2035 T7174 T7173 pobj ANA,of
R2036 T7259 T7254 xcomp be,reported
R2037 T7175 T7174 cc and,ANA
R2038 T7260 T7259 attr one,be
R2039 T7176 T7177 amod anti-chromatin,Ab
R2040 T7177 T7174 conj Ab,ANA
R2041 T7178 T7152 punct .,demonstrates
R2042 T7261 T7260 prep of,one
R2043 T7180 T7181 advcl Consistent,found
R2044 T7262 T7263 det the,strains
R2045 T7182 T7180 prep with,Consistent
R2046 T7183 T7184 det this,explanation
R2047 T7263 T7261 pobj strains,of
R2048 T7184 T7182 pobj explanation,with
R2049 T7185 T7181 punct ", ",found
R2050 T7264 T7263 amod murine,strains
R2051 T7186 T7181 nsubj we,found
R2052 T7187 T7188 mark that,have
R2053 T7188 T7181 ccomp have,found
R2054 T7265 T7263 acl defined,strains
R2055 T7189 T7190 det the,mice
R2056 T7190 T7188 nsubj mice,have
R2057 T7191 T7190 nummod 129,mice
R2058 T7266 T7265 prep as,defined
R2059 T7192 T7193 advmod significantly,higher
R2060 T7193 T7194 amod higher,levels
R2061 T7267 T7268 amod low,producers
R2062 T7194 T7188 dobj levels,have
R2063 T7195 T7194 prep of,levels
R2064 T7196 T7195 pobj Apcs,of
R2065 T7268 T7266 pobj producers,as
R2066 T7197 T7194 prep in,levels
R2067 T7198 T7197 pobj circulation,in
R2068 T7269 T7268 compound Apcs,producers
R2069 T7199 T7188 prep compared,have
R2070 T7200 T7199 prep with,compared
R2071 T7201 T7202 det the,mice
R2073 T7202 T7200 pobj mice,with
R2074 T7203 T7202 nmod C57BL,mice
R2075 T7204 T7203 punct /,C57BL
R2076 T7271 T7254 meta Pepys,reported
R2077 T7205 T7203 nummod 6,C57BL
R2078 T7206 T7207 punct (,0.0001
R2079 T7272 T7271 nmod et,Pepys
R2080 T7207 T7181 parataxis 0.0001,found
R2081 T7273 T7271 nmod al.,Pepys
R2082 T7208 T7209 dep median,mg
R2083 T7274 T7271 nummod 1979,Pepys
R2084 T7275 T7271 punct ;,Pepys
R2085 T7276 T7271 nmod Baltz,Pepys
R2086 T7277 T7271 nmod et,Pepys
R2087 T7278 T7271 nmod al.,Pepys
R2088 T7315 T7316 mark that,is
R2089 T7279 T7271 nummod 1980,Pepys
R2090 T7316 T7314 ccomp is,indicating
R2091 T7317 T7318 det a,variant
R2092 T7280 T7271 punct ),Pepys
R2093 T7318 T7316 nsubj variant,is
R2094 T7319 T7318 amod structural,variant
R2095 T7281 T7254 punct .,reported
R2096 T7320 T7318 prep of,variant
R2097 T7321 T7322 det the,protein
R2098 T7322 T7320 pobj protein,of
R2099 T7283 T7284 prep In,failed
R2100 T7323 T7316 acomp unlikely,is
R2101 T7324 T7325 aux to,be
R2102 T7325 T7323 xcomp be,unlikely
R2103 T7285 T7283 pobj addition,In
R2104 T7326 T7327 det the,explanation
R2105 T7327 T7325 attr explanation,be
R2106 T7328 T7327 prep for,explanation
R2107 T7329 T7330 poss our,findings
R2108 T7330 T7328 pobj findings,for
R2109 T7286 T7284 punct ", ",failed
R2110 T7331 T7284 punct .,failed
R2111 T7333 T7334 nsubj This,is
R2112 T7287 T7288 compound sequence,analysis
R2113 T7335 T7334 acomp consistent,is
R2114 T7336 T7335 prep with,consistent
R2115 T7288 T7284 nsubj analysis,failed
R2116 T7337 T7338 det a,report
R2117 T7338 T7336 pobj report,with
R2118 T7339 T7338 amod previous,report
R2119 T7289 T7288 prep of,analysis
R2120 T7340 T7338 prep by,report
R2121 T7341 T7340 pobj Drake,by
R2122 T7342 T7343 advmod et,al.
R2123 T7290 T7291 det the,region
R2124 T7343 T7341 advmod al.,Drake
R2125 T7344 T7341 punct (,Drake
R2126 T7345 T7341 npadvmod 1996,Drake
R2127 T7291 T7289 pobj region,of
R2128 T7346 T7341 punct ),Drake
R2129 T7347 T7348 dep that,showed
R2130 T7348 T7338 relcl showed,report
R2131 T7292 T7291 amod entire,region
R2132 T7349 T7350 det no,differences
R2133 T7350 T7348 dobj differences,showed
R2134 T7351 T7352 nmod Apcs,sequence
R2135 T7293 T7291 nmod Apcs,region
R2136 T7352 T7350 compound sequence,differences
R2137 T7353 T7352 amod coding,sequence
R2138 T7354 T7348 prep amongst,showed
R2139 T7355 T7356 amod several,strains
R2140 T7356 T7354 pobj strains,amongst
R2141 T7357 T7356 amod autoimmune,strains
R2142 T7294 T7291 amod coding,region
R2143 T7358 T7357 cc and,autoimmune
R2144 T7359 T7357 conj nonautoimmune,autoimmune
R2145 T7360 T7356 amod murine,strains
R2146 T7361 T7334 punct .,is
R2147 T7295 T7288 prep in,analysis
R2148 T7363 T7364 prep In,contributed
R2149 T7296 T7297 det both,strains
R2150 T7365 T7363 pobj addition,In
R2151 T7366 T7365 prep to,addition
R2152 T7297 T7295 pobj strains,in
R2153 T7367 T7368 det the,segments
R2154 T7368 T7366 pobj segments,to
R2155 T7369 T7370 advmod 129,derived
R2156 T7298 T7299 aux to,identify
R2157 T7370 T7368 amod derived,segments
R2158 T7371 T7370 punct -,derived
R2159 T7372 T7364 punct ", ",contributed
R2160 T7299 T7284 xcomp identify,failed
R2161 T7373 T7364 prep in,contributed
R2162 T7374 T7375 det both,cohorts
R2163 T7300 T7301 det any,polymorphisms
R2164 T7375 T7373 pobj cohorts,in
R2165 T7376 T7377 det the,strain
R2166 T7377 T7364 nsubj strain,contributed
R2167 T7301 T7299 dobj polymorphisms,identify
R2168 T7378 T7377 nmod C57BL,strain
R2169 T7379 T7378 punct /,C57BL
R2170 T7380 T7378 nummod 6,C57BL
R2171 T7302 T7303 amod coding,sequence
R2172 T7381 T7364 prep to,contributed
R2173 T7382 T7383 det the,traits
R2174 T7383 T7381 pobj traits,to
R2175 T7303 T7301 compound sequence,polymorphisms
R2176 T7384 T7383 amod autoimmune,traits
R2177 T7385 T7364 prep with,contributed
R2178 T7386 T7387 nummod one,locus
R2179 T7304 T7299 prep in,identify
R2180 T7387 T7385 pobj locus,with
R2181 T7388 T7387 amod major,locus
R2182 T7389 T7387 compound susceptibility,locus
R2183 T7305 T7306 det the,gene
R2184 T7390 T7387 prep on,locus
R2185 T7391 T7390 pobj Chromosome,on
R2186 T7392 T7391 nummod 3,Chromosome
R2187 T7306 T7304 pobj gene,in
R2188 T7393 T7364 punct .,contributed
R2189 T7395 T7396 det A,region
R2190 T7396 T7398 nsubj region,showed
R2191 T7307 T7306 compound Apcs,gene
R2192 T7397 T7396 amod genomic,region
R2194 T7308 T7309 punct (,shown
R2195 T7400 T7399 pobj D3Mit40,between
R2196 T7401 T7400 cc and,D3Mit40
R2197 T7402 T7400 conj D3Mit13,D3Mit40
R2198 T7309 T7299 parataxis shown,identify
R2199 T7403 T7396 punct ", ",region
R2200 T7404 T7396 prep with,region
R2201 T7310 T7309 nsubj data,shown
R2202 T7405 T7406 det an,peak
R2203 T7406 T7404 pobj peak,with
R2204 T7311 T7309 neg not,shown
R2205 T7407 T7406 amod estimated,peak
R2206 T7408 T7406 prep at,peak
R2207 T7312 T7309 punct ),shown
R2208 T7409 T7410 nmod position,cM
R2209 T7410 T7408 pobj cM,at
R2210 T7411 T7412 advmod approximately,51
R2211 T7313 T7299 punct ", ",identify
R2212 T7412 T7410 nummod 51,cM
R2213 T7413 T7398 punct ", ",showed
R2214 T7414 T7415 det a,linkage
R2215 T7314 T7299 advcl indicating,identify
R2216 T7415 T7398 dobj linkage,showed
R2217 T7416 T7415 amod significant,linkage
R2218 T7417 T7415 prep to,linkage
R2219 T7421 T7422 amod weaker,linkages
R2220 T7418 T7419 compound ANA,production
R2221 T7419 T7417 pobj production,to
R2222 T7420 T7415 cc and,linkage
R2223 T7422 T7415 conj linkages,linkage
R2224 T7423 T7422 prep to,linkages
R2225 T7424 T7425 amod anti-ssDNA,production
R2226 T7425 T7423 pobj production,to
R2227 T7526 T7522 prep on,effect
R2228 T7527 T7528 amod distal,Chromosome
R2229 T7426 T7424 cc and,anti-ssDNA
R2230 T7528 T7526 pobj Chromosome,on
R2231 T7529 T7528 nummod 1,Chromosome
R2232 T7427 T7424 conj anti-chromatin,anti-ssDNA
R2233 T7530 T7519 punct ", ",controlling
R2234 T7531 T7532 mark as,described
R2235 T7532 T7519 advcl described,controlling
R2236 T7428 T7429 punct (,see
R2237 T7533 T7532 advmod previously,described
R2238 T7534 T7535 punct (,Zeng
R2239 T7429 T7422 parataxis see,linkages
R2240 T7535 T7532 meta Zeng,described
R2241 T7536 T7535 nummod 1994,Zeng
R2242 T7537 T7535 punct ),Zeng
R2243 T7538 T7490 punct .,investigated
R2244 T7540 T7541 det The,results
R2245 T7541 T7542 nsubj results,showed
R2246 T7430 T7429 dobj Table,see
R2247 T7543 T7541 prep of,results
R2248 T7544 T7545 det this,analysis
R2249 T7431 T7430 nummod 3,Table
R2250 T7545 T7543 pobj analysis,of
R2251 T7546 T7547 mark that,increased
R2252 T7432 T7430 punct ;,Table
R2253 T7547 T7542 ccomp increased,showed
R2254 T7433 T7430 npadvmod Figure,Table
R2255 T7548 T7549 det the,support
R2256 T7549 T7547 nsubj support,increased
R2257 T7434 T7433 nummod 7,Figure
R2258 T7550 T7549 amod statistical,support
R2259 T7551 T7549 prep for,support
R2260 T7552 T7553 det the,linkage
R2261 T7435 T7429 punct ),see
R2262 T7553 T7551 pobj linkage,for
R2263 T7554 T7553 prep of,linkage
R2264 T7436 T7398 punct .,showed
R2265 T7555 T7556 det the,locus
R2266 T7556 T7554 pobj locus,of
R2267 T7557 T7556 nmod C57BL,locus
R2268 T7438 T7439 det The,frequency
R2269 T7558 T7557 punct /,C57BL
R2270 T7559 T7557 nummod 6,C57BL
R2271 T7560 T7553 prep on,linkage
R2272 T7561 T7560 pobj Chromosome,on
R2273 T7439 T7441 nsubj frequency,imply
R2274 T7562 T7561 nummod 3,Chromosome
R2275 T7563 T7553 prep for,linkage
R2276 T7564 T7563 pobj ANA,for
R2277 T7440 T7439 amod high,frequency
R2278 T7565 T7547 prep from,increased
R2279 T7566 T7565 pobj logarithm,from
R2280 T7567 T7566 prep of,logarithm
R2281 T7442 T7439 prep of,frequency
R2282 T7568 T7567 pobj odds,of
R2283 T7569 T7566 punct (,logarithm
R2284 T7570 T7566 appos LOD,logarithm
R2285 T7443 T7444 amod autoimmune,phenotype
R2286 T7571 T7566 punct ),logarithm
R2287 T7572 T7566 nummod 5.4,logarithm
R2288 T7444 T7442 pobj phenotype,of
R2289 T7573 T7565 prep to,from
R2290 T7574 T7573 pobj LOD,to
R2291 T7575 T7574 nummod 6.4,LOD
R2292 T7445 T7439 prep in,frequency
R2293 T7576 T7542 punct .,showed
R2294 T7578 T7579 prep In,identified
R2295 T7580 T7578 pobj contrast,In
R2296 T7581 T7580 prep to,contrast
R2297 T7446 T7447 det the,background
R2298 T7582 T7583 det these,associations
R2299 T7583 T7581 pobj associations,to
R2300 T7584 T7583 amod strong,associations
R2301 T7447 T7445 pobj background,in
R2302 T7585 T7583 prep with,associations
R2303 T7586 T7587 nmod disease,markers
R2304 T7587 T7585 pobj markers,with
R2305 T7448 T7447 punct (,background
R2306 T7588 T7587 amod serological,markers
R2307 T7589 T7579 punct ", ",identified
R2308 T7590 T7591 det the,analysis
R2309 T7449 T7447 nummod 129,background
R2310 T7591 T7579 nsubj analysis,identified
R2311 T7592 T7591 compound QTL,analysis
R2312 T7593 T7594 advmod only,linkages
R2313 T7450 T7449 punct ×,129
R2314 T7594 T7579 dobj linkages,identified
R2315 T7595 T7594 nummod two,linkages
R2316 T7451 T7449 appos C57BL,129
R2317 T7596 T7594 amod potential,linkages
R2318 T7597 T7594 prep to,linkages
R2319 T7452 T7451 punct /,C57BL
R2320 T7598 T7597 pobj glomerulonephritis,to
R2321 T7599 T7594 punct : ,linkages
R2322 T7600 T7594 appos one,linkages
R2323 T7453 T7451 nummod 6,C57BL
R2324 T7601 T7600 prep in,one
R2325 T7602 T7603 det the,mice
R2326 T7454 T7449 punct ),129
R2327 T7603 T7601 pobj mice,in
R2328 T7604 T7605 amod wild,type
R2329 T7455 T7449 amod hybrid,129
R2330 T7456 T7447 amod genetic,background
R2331 T7457 T7439 cc and,frequency
R2332 T7605 T7603 compound type,mice
R2333 T7458 T7459 poss its,absence
R2334 T7606 T7605 punct -,type
R2335 T7607 T7600 prep on,one
R2336 T7459 T7439 conj absence,frequency
R2337 T7608 T7607 pobj Chromosome,on
R2338 T7609 T7608 nummod 7,Chromosome
R2339 T7460 T7459 prep in,absence
R2340 T7610 T7600 prep across,one
R2341 T7611 T7612 det a,region
R2342 T7612 T7610 pobj region,across
R2343 T7461 T7460 pobj either,in
R2344 T7613 T7614 nummod 10,cM
R2345 T7614 T7612 compound cM,region
R2346 T7615 T7612 prep between,region
R2347 T7616 T7615 pobj D7Mit246,between
R2348 T7617 T7618 punct (,cM
R2349 T7618 T7616 parataxis cM,D7Mit246
R2350 T7462 T7461 prep of,either
R2351 T7619 T7618 nummod 15,cM
R2352 T7620 T7618 punct ),cM
R2353 T7621 T7616 cc and,D7Mit246
R2354 T7463 T7464 det the,strains
R2355 T7622 T7616 conj D7Mit145,D7Mit246
R2356 T7623 T7624 punct (,cM
R2357 T7624 T7622 parataxis cM,D7Mit145
R2358 T7464 T7462 pobj strains,of
R2359 T7625 T7624 nummod 26.5,cM
R2360 T7626 T7624 punct ),cM
R2361 T7627 T7600 prep of,one
R2362 T7465 T7464 amod inbred,strains
R2363 T7628 T7629 nummod 129,origin
R2364 T7629 T7627 pobj origin,of
R2365 T7466 T7464 amod parental,strains
R2366 T7630 T7631 punct (,LOD
R2367 T7631 T7629 parataxis LOD,origin
R2368 T7467 T7468 mark that,are
R2369 T7468 T7441 ccomp are,imply
R2370 T7469 T7468 expl there,are
R2371 T7632 T7631 nummod 2.86,LOD
R2372 T7633 T7631 punct ", ",LOD
R2373 T7470 T7471 amod essential,interactions
R2374 T7634 T7635 nsubj p,0.0013
R2375 T7471 T7468 attr interactions,are
R2376 T7635 T7631 ccomp 0.0013,LOD
R2377 T7636 T7635 punct =,0.0013
R2378 T7637 T7631 punct ),LOD
R2379 T7472 T7471 prep between,interactions
R2380 T7638 T7600 punct ", ",one
R2381 T7639 T7600 cc and,one
R2382 T7640 T7600 conj one,one
R2383 T7473 T7474 npadvmod 129,derived
R2384 T7641 T7640 prep on,one
R2385 T7642 T7641 pobj Chromosome,on
R2386 T7474 T7481 amod derived,alleles
R2387 T7643 T7642 nummod 17,Chromosome
R2388 T7644 T7640 prep between,one
R2389 T7645 T7644 pobj D17Mit100,between
R2390 T7475 T7473 punct -,129
R2391 T7646 T7647 punct (,cM
R2392 T7476 T7473 cc and,129
R2393 T7647 T7645 parataxis cM,D17Mit100
R2394 T7477 T7473 conj C57BL,129
R2395 T7648 T7647 nummod 11.7,cM
R2396 T7649 T7647 punct ),cM
R2397 T7650 T7645 cc and,D17Mit100
R2398 T7651 T7645 conj D17Mit216,D17Mit100
R2399 T7652 T7653 punct (,cM
R2400 T7478 T7477 punct /,C57BL
R2401 T7653 T7651 parataxis cM,D17Mit216
R2402 T7654 T7653 nummod 29.4,cM
R2403 T7655 T7653 punct ),cM
R2404 T7479 T7477 nummod 6,C57BL
R2405 T7656 T7640 prep from,one
R2406 T7480 T7477 punct -,C57BL
R2407 T7657 T7658 det the,strain
R2408 T7658 T7656 pobj strain,from
R2409 T7659 T7658 nmod C57BL,strain
R2410 T7481 T7472 pobj alleles,between
R2411 T7660 T7659 punct /,C57BL
R2412 T7661 T7659 nummod 6,C57BL
R2413 T7482 T7468 prep for,are
R2414 T7662 T7663 punct (,0.049
R2415 T7663 T7640 parataxis 0.049,one
R2416 T7664 T7663 dep LOD,0.049
R2417 T7483 T7484 det the,expression
R2418 T7665 T7664 nummod 1.3,LOD
R2419 T7666 T7663 punct ", ",0.049
R2420 T7484 T7482 pobj expression,for
R2421 T7667 T7663 nsubj p,0.049
R2422 T7668 T7663 punct =,0.049
R2423 T7669 T7663 cc and,0.049
R2424 T7485 T7484 prep of,expression
R2425 T7670 T7671 dep LOD,0.021
R2426 T7671 T7663 conj 0.021,0.049
R2427 T7672 T7670 nummod 1.67,LOD
R2428 T7486 T7485 pobj autoimmunity,of
R2429 T7673 T7671 punct ", ",0.021
R2430 T7487 T7441 punct .,imply
R2431 T7674 T7671 nsubj p,0.021
R2432 T7675 T7671 punct =,0.021
R2433 T7676 T7671 prep in,0.021
R2434 T7677 T7678 det the,mice
R2435 T7489 T7490 nsubj We,investigated
R2436 T7678 T7676 pobj mice,in
R2437 T7679 T7680 amod wild,type
R2438 T7680 T7678 nmod type,mice
R2439 T7681 T7680 punct -,type
R2440 T7491 T7490 advmod further,investigated
R2441 T7682 T7680 cc and,type
R2442 T7683 T7680 conj Apcs,type
R2443 T7684 T7683 punct −,Apcs
R2444 T7685 T7683 punct /,Apcs
R2445 T7492 T7493 det the,effects
R2446 T7686 T7683 punct −,Apcs
R2447 T7687 T7671 punct ", ",0.021
R2448 T7688 T7671 conj respectively,0.021
R2449 T7689 T7688 punct ),respectively
R2450 T7690 T7579 punct .,identified
R2451 T7493 T7490 dobj effects,investigated
R2452 T7692 T7693 amod Histological,evidence
R2453 T7693 T7694 nsubjpass evidence,found
R2454 T7494 T7493 prep of,effects
R2455 T7695 T7693 prep of,evidence
R2456 T7696 T7695 pobj glomerulonephritis,of
R2457 T7495 T7494 pobj genes,of
R2458 T7697 T7694 auxpass was,found
R2459 T7698 T7694 advmod only,found
R2460 T7699 T7694 prep in,found
R2461 T7496 T7495 prep from,genes
R2462 T7700 T7701 advmod approximately,20
R2463 T7701 T7702 nummod 20,%
R2464 T7702 T7699 pobj %,in
R2465 T7497 T7498 det the,background
R2466 T7703 T7702 prep of,%
R2467 T7704 T7705 det the,mice
R2468 T7498 T7496 pobj background,from
R2469 T7705 T7703 pobj mice,of
R2470 T7706 T7705 prep in,mice
R2471 T7707 T7708 det each,cohort
R2472 T7499 T7498 nmod C57BL,background
R2473 T7708 T7706 pobj cohort,in
R2474 T7709 T7694 punct ", ",found
R2475 T7710 T7711 dep which,reduces
R2476 T7500 T7499 punct /,C57BL
R2477 T7711 T7694 advcl reduces,found
R2478 T7712 T7713 det the,power
R2479 T7713 T7711 dobj power,reduces
R2480 T7501 T7499 nummod 6,C57BL
R2481 T7714 T7713 prep of,power
R2482 T7715 T7716 det the,analysis
R2483 T7502 T7490 prep by,investigated
R2484 T7716 T7714 pobj analysis,of
R2485 T7717 T7716 compound QTL,analysis
R2486 T7718 T7711 prep for,reduces
R2487 T7503 T7502 pcomp repeating,by
R2488 T7719 T7720 det this,trait
R2489 T7720 T7718 pobj trait,for
R2490 T7721 T7720 compound disease,trait
R2491 T7504 T7505 det the,analysis
R2492 T7722 T7694 punct .,found
R2493 T7505 T7503 dobj analysis,repeating
R2494 T7506 T7505 compound linkage,analysis
R2495 T7507 T7503 prep in,repeating
R2496 T7508 T7509 punct (,mice
R2497 T7509 T7507 pobj mice,in
R2498 T7510 T7509 nummod 129,mice
R2499 T7511 T7510 punct ×,129
R2500 T7512 T7510 appos C57BL,129
R2501 T7513 T7512 punct /,C57BL
R2502 T7514 T7512 nummod 6,C57BL
R2503 T7515 T7509 punct ),mice
R2504 T7516 T7509 compound F2,mice
R2505 T7517 T7503 punct ", ",repeating
R2506 T7518 T7519 mark whilst,controlling
R2507 T7519 T7503 advcl controlling,repeating
R2508 T7520 T7519 prep for,controlling
R2509 T7521 T7522 det the,effect
R2510 T7522 T7520 pobj effect,for
R2511 T7523 T7524 advmod very,strong
R2512 T7524 T7522 amod strong,effect
R2513 T7525 T7522 nummod 129,effect
R2516 T8759 T8758 prep of,Production
R2517 T8760 T8761 det a,Line
R2518 T8761 T8759 pobj Line,of
R2519 T8762 T8761 nmod C57BL,Line
R2520 T8763 T8762 punct /,C57BL
R2521 T8764 T8762 nummod 6,C57BL
R2522 T8765 T8762 punct .,C57BL
R2523 T8766 T8762 appos 129,C57BL
R2524 T8767 T8761 nmod Chromosome,Line
R2525 T8768 T8767 nummod 1,Chromosome
R2526 T8769 T8761 amod Congenic,Line
R2527 T8770 T8758 cc and,Production
R2528 T8771 T8772 poss Its,Analysis
R2529 T8772 T8758 conj Analysis,Production
R2530 T8773 T8772 amod Phenotypic,Analysis
R2531 T8775 T8776 nsubj We,generated
R2532 T8777 T8778 det a,line
R2533 T8778 T8776 dobj line,generated
R2534 T8779 T8778 nmod C57BL,line
R2535 T8780 T8779 punct /,C57BL
R2536 T8781 T8779 nummod 6,C57BL
R2537 T8782 T8778 amod congenic,line
R2538 T8783 T8778 acl carrying,line
R2539 T8784 T8785 det the,region
R2540 T8785 T8783 dobj region,carrying
R2541 T8786 T8785 amod telomeric,region
R2542 T8787 T8785 prep of,region
R2543 T8788 T8787 pobj Chromosome,of
R2544 T8789 T8788 nummod 1,Chromosome
R2545 T8790 T8783 prep from,carrying
R2546 T8791 T8792 det the,strain
R2547 T8792 T8790 pobj strain,from
R2548 T8793 T8792 nummod 129,strain
R2549 T8794 T8792 compound mouse,strain
R2550 T8795 T8776 punct ", ",generated
R2551 T8796 T8776 prep in,generated
R2552 T8797 T8796 pobj order,in
R2553 T8798 T8799 aux to,dissect
R2554 T8799 T8797 acl dissect,order
R2555 T8800 T8801 det the,phenotype
R2556 T8801 T8799 dobj phenotype,dissect
R2557 T8802 T8801 amod complex,phenotype
R2558 T8803 T8801 amod polygenic,phenotype
R2559 T8804 T8801 compound disease,phenotype
R2560 T8805 T8801 prep of,phenotype
R2561 T8806 T8807 det the,strain
R2562 T8807 T8805 pobj strain,of
R2563 T8808 T8807 punct (,strain
R2564 T8809 T8807 nmod C57BL,strain
R2565 T8810 T8809 punct /,C57BL
R2566 T8811 T8809 nummod 6,C57BL
R2567 T8812 T8809 punct ×,C57BL
R2568 T8813 T8814 compound 129,Sv
R2569 T8814 T8809 appos Sv,C57BL
R2570 T8815 T8814 punct /,Sv
R2571 T8816 T8807 punct ),strain
R2572 T8817 T8807 compound F2,strain
R2573 T8818 T8807 compound hybrid,strain
R2574 T8819 T8799 prep into,dissect
R2575 T8820 T8821 poss its,components
R2576 T8821 T8819 pobj components,into
R2577 T8822 T8821 amod individual,components
R2578 T8823 T8821 amod genetic,components
R2579 T8824 T8776 punct .,generated
R2580 T8826 T8827 det The,interval
R2581 T8827 T8829 nsubjpass interval,backcrossed
R2582 T8828 T8827 nummod 129,interval
R2583 T8830 T8829 auxpass was,backcrossed
R2584 T8831 T8832 nummod seven,times
R2585 T8832 T8829 npadvmod times,backcrossed
R2586 T8833 T8829 prep onto,backcrossed
R2587 T8834 T8833 pobj C57BL,onto
R2588 T8835 T8834 punct /,C57BL
R2589 T8836 T8834 nummod 6,C57BL
R2590 T8837 T8829 punct ", ",backcrossed
R2591 T8838 T8829 cc and,backcrossed
R2592 T8839 T8840 prep at,determined
R2593 T8840 T8829 conj determined,backcrossed
R2594 T8841 T8842 det each,generation
R2595 T8842 T8839 pobj generation,at
R2596 T8843 T8844 det the,presence
R2597 T8844 T8840 nsubjpass presence,determined
R2598 T8845 T8844 cc or,presence
R2599 T8846 T8844 conj absence,presence
R2600 T8847 T8844 prep of,presence
R2601 T8848 T8849 det the,interval
R2602 T8849 T8847 pobj interval,of
R2603 T8850 T8849 nmod Chromosome,interval
R2604 T8851 T8850 nummod 1,Chromosome
R2605 T8852 T8840 auxpass was,determined
R2606 T8853 T8840 prep with,determined
R2607 T8854 T8855 amod several,markers
R2608 T8855 T8853 pobj markers,with
R2609 T8856 T8855 compound microsatellite,markers
R2610 T8857 T8840 punct .,determined
R2611 T8859 T8860 det Each,generation
R2612 T8860 T8862 nsubjpass generation,screened
R2613 T8861 T8860 amod backcrossed,generation
R2614 T8863 T8862 auxpass was,screened
R2615 T8864 T8862 prep with,screened
R2616 T8865 T8866 amod more,three
R2617 T8866 T8868 nummod three,markers
R2618 T8867 T8866 quantmod than,three
R2619 T8868 T8864 pobj markers,with
R2620 T8869 T8868 prep per,markers
R2621 T8870 T8869 pobj chromosome,per
R2622 T8871 T8872 aux to,facilitate
R2623 T8872 T8862 advcl facilitate,screened
R2624 T8873 T8874 det the,removal
R2625 T8874 T8872 dobj removal,facilitate
R2626 T8875 T8874 prep of,removal
R2627 T8876 T8877 amod unselected,regions
R2628 T8877 T8875 pobj regions,of
R2629 T8878 T8877 nummod 129,regions
R2630 T8879 T8877 amod genomic,regions
R2631 T8880 T8862 punct .,screened
R2632 T8882 T8883 prep At,extended
R2633 T8884 T8885 det the,end
R2634 T8885 T8882 pobj end,At
R2635 T8886 T8885 prep of,end
R2636 T8887 T8888 det the,backcrossing
R2637 T8888 T8886 pobj backcrossing,of
R2638 T8889 T8883 punct ", ",extended
R2639 T8890 T8891 det the,interval
R2640 T8891 T8883 nsubj interval,extended
R2641 T8892 T8893 advmod 129,derived
R2642 T8893 T8891 amod derived,interval
R2643 T8894 T8893 punct -,derived
R2644 T8895 T8891 nmod Chromosome,interval
R2645 T8896 T8895 nummod 1,Chromosome
R2646 T8897 T8891 prep in,interval
R2647 T8898 T8899 det the,mice
R2648 T8899 T8897 pobj mice,in
R2649 T8900 T8899 amod congenic,mice
R2650 T8901 T8883 prep from,extended
R2651 T8902 T8903 compound microsatellite,marker
R2652 T8903 T8901 pobj marker,from
R2653 T8904 T8903 appos D1Mit105,marker
R2654 T8905 T8901 prep to,from
R2655 T8906 T8905 pobj D1Mit223,to
R2656 T8907 T8908 punct (,cM
R2657 T8908 T8906 parataxis cM,D1Mit223
R2658 T8909 T8910 quantmod 80,106
R2659 T8910 T8908 nummod 106,cM
R2660 T8911 T8910 punct –,106
R2661 T8912 T8908 punct ),cM
R2662 T8913 T8883 punct ", ",extended
R2663 T8914 T8915 dep which,encompasses
R2664 T8915 T8883 advcl encompasses,extended
R2665 T8916 T8917 det the,interval
R2666 T8917 T8915 dobj interval,encompasses
R2667 T8918 T8919 advmod most,important
R2668 T8919 T8917 amod important,interval
R2669 T8920 T8917 nummod 129,interval
R2670 T8921 T8917 acl identified,interval
R2671 T8922 T8921 agent by,identified
R2672 T8923 T8924 det the,studies
R2673 T8924 T8922 pobj studies,by
R2674 T8925 T8924 compound linkage,studies
R2675 T8926 T8921 prep in,identified
R2676 T8927 T8928 det the,mice
R2677 T8928 T8926 pobj mice,in
R2678 T8929 T8928 punct (,mice
R2679 T8930 T8928 nmod C57BL,mice
R2680 T8931 T8930 punct /,C57BL
R2681 T8932 T8930 nummod 6,C57BL
R2682 T8933 T8930 punct ×,C57BL
R2683 T8934 T8935 compound 129,Sv
R2684 T8935 T8930 appos Sv,C57BL
R2685 T8936 T8935 punct /,Sv
R2686 T8937 T8928 punct ),mice
R2687 T8938 T8928 compound F2,mice
R2688 T8939 T8883 punct .,extended
R2689 T8941 T8942 amod Female,mice
R2690 T8942 T8946 nsubjpass mice,monitored
R2691 T8943 T8942 nmod Chromosome,mice
R2692 T8944 T8943 nummod 1,Chromosome
R2693 T8945 T8942 amod congenic,mice
R2694 T8947 T8948 punct (,C57BL
R2695 T8948 T8942 parataxis C57BL,mice
R2696 T8949 T8948 punct /,C57BL
R2697 T8950 T8948 nummod 6,C57BL
R2698 T8951 T8948 punct .,C57BL
R2699 T8952 T8948 nummod 129,C57BL
R2700 T8953 T8954 punct [,D1Mit105
R2701 T8954 T8948 parataxis D1Mit105,C57BL
R2702 T8955 T8956 punct –,223
R2703 T8956 T8954 prep 223,D1Mit105
R2704 T8957 T8954 punct ],D1Mit105
R2705 T8958 T8948 punct ),C57BL
R2706 T8959 T8942 punct ", ",mice
R2707 T8960 T8961 advmod together,with
R2708 T8961 T8942 prep with,mice
R2709 T8962 T8963 npadvmod sex,matched
R2710 T8963 T8965 amod matched,mice
R2711 T8964 T8963 punct -,matched
R2712 T8965 T8961 pobj mice,with
R2713 T8966 T8965 nmod Apcs,mice
R2714 T8967 T8966 punct −,Apcs
R2715 T8968 T8966 punct /,Apcs
R2716 T8969 T8966 punct −,Apcs
R2717 T8970 T8965 acl backcrossed,mice
R2718 T8971 T8970 prep onto,backcrossed
R2719 T8972 T8971 pobj C57BL,onto
R2720 T8973 T8972 punct /,C57BL
R2721 T8974 T8972 nummod 6,C57BL
R2722 T8975 T8970 prep for,backcrossed
R2723 T8976 T8977 nummod ten,generations
R2724 T8977 T8975 pobj generations,for
R2725 T8978 T8965 punct (,mice
R2726 T8979 T8965 appos C57BL,mice
R2727 T8980 T8979 punct /,C57BL
R2728 T8981 T8979 nummod 6,C57BL
R2729 T8982 T8979 punct .,C57BL
R2730 T8983 T8979 appos Apcs,C57BL
R2731 T8984 T8983 punct −,Apcs
R2732 T8985 T8983 punct /,Apcs
R2733 T8986 T8983 punct −,Apcs
R2734 T8987 T8965 punct ),mice
R2735 T8988 T8965 cc and,mice
R2736 T8989 T8990 nmod C57BL,controls
R2737 T8990 T8965 conj controls,mice
R2738 T8991 T8989 punct /,C57BL
R2739 T8992 T8989 nummod 6,C57BL
R2740 T8993 T8946 punct ", ",monitored
R2741 T8994 T8946 auxpass were,monitored
R2742 T8995 T8946 prep for,monitored
R2743 T8996 T8997 det the,presence
R2744 T8997 T8995 pobj presence,for
R2745 T8998 T8997 prep of,presence
R2746 T8999 T8998 pobj lupus,of
R2747 T9000 T8946 punct .,monitored
R2748 T9002 T9003 prep In,mapped
R2749 T9004 T9005 det the,mice
R2750 T9005 T9002 pobj mice,In
R2751 T9006 T9005 nmod C57BL,mice
R2752 T9007 T9006 punct /,C57BL
R2753 T9008 T9006 nummod 6,C57BL
R2754 T9009 T9006 punct .,C57BL
R2755 T9010 T9006 appos Apcs,C57BL
R2756 T9011 T9010 punct −,Apcs
R2757 T9012 T9010 punct /,Apcs
R2758 T9013 T9010 punct −,Apcs
R2759 T9014 T9003 punct ", ",mapped
R2760 T9015 T9016 det the,genome
R2761 T9016 T9003 nsubjpass genome,mapped
R2762 T9017 T9016 nummod 129,genome
R2763 T9018 T9016 prep around,genome
R2764 T9019 T9020 det the,locus
R2765 T9020 T9018 pobj locus,around
R2766 T9021 T9020 compound Apcs,locus
R2767 T9022 T9003 auxpass was,mapped
R2768 T9023 T9003 prep as,mapped
R2769 T9024 T9025 det a,stretch
R2770 T9025 T9023 pobj stretch,as
R2771 T9026 T9025 prep of,stretch
R2772 T9027 T9028 advmod approximately,17
R2773 T9028 T9029 nummod 17,cM
R2774 T9029 T9026 pobj cM,of
R2775 T9030 T9025 punct ", ",stretch
R2776 T9031 T9025 acl positioned,stretch
R2777 T9032 T9031 prep from,positioned
R2778 T9033 T9034 nummod 87.9,cM
R2779 T9034 T9032 pobj cM,from
R2780 T9035 T9036 punct (,D1Mit15
R2781 T9036 T9034 parataxis D1Mit15,cM
R2782 T9037 T9036 punct ),D1Mit15
R2783 T9038 T9032 prep to,from
R2784 T9039 T9040 nummod 105,cM
R2785 T9040 T9038 pobj cM,to
R2786 T9041 T9042 punct (,D1Mit17
R2787 T9042 T9040 parataxis D1Mit17,cM
R2788 T9043 T9042 punct ),D1Mit17
R2789 T9044 T9003 punct .,mapped
R2790 T9046 T9047 advmod Thus,carried
R2791 T9048 T9047 punct ", ",carried
R2792 T9049 T9050 det the,line
R2793 T9050 T9047 nsubj line,carried
R2794 T9051 T9050 amod congenic,line
R2795 T9052 T9053 det a,region
R2796 T9053 T9047 dobj region,carried
R2797 T9054 T9053 amod similar,region
R2798 T9055 T9053 nummod 129,region
R2799 T9056 T9057 punct (,cM
R2800 T9057 T9053 parataxis cM,region
R2801 T9058 T9059 quantmod 80,106
R2802 T9059 T9057 nummod 106,cM
R2803 T9060 T9059 punct –,106
R2804 T9061 T9057 punct ),cM
R2805 T9062 T9053 prep to,region
R2806 T9063 T9064 det the,one
R2807 T9064 T9062 pobj one,to
R2808 T9065 T9064 amod present,one
R2809 T9066 T9065 prep in,present
R2810 T9067 T9068 det the,mice
R2811 T9068 T9066 pobj mice,in
R2812 T9069 T9068 nmod C57BL,mice
R2813 T9070 T9069 punct /,C57BL
R2814 T9071 T9069 nummod 6,C57BL
R2815 T9072 T9069 punct .,C57BL
R2816 T9073 T9069 appos Apcs,C57BL
R2817 T9074 T9073 punct −,Apcs
R2818 T9075 T9073 punct /,Apcs
R2819 T9076 T9073 punct −,Apcs
R2820 T9077 T9078 punct (,cM
R2821 T9078 T9068 parataxis cM,mice
R2822 T9079 T9080 quantmod 87.9,105
R2823 T9080 T9078 nummod 105,cM
R2824 T9081 T9080 punct –,105
R2825 T9082 T9078 punct ),cM
R2826 T9083 T9047 punct .,carried
R2827 T9085 T9086 prep At,sacrificed
R2828 T9087 T9088 nummod 1,y
R2829 T9088 T9085 pobj y,At
R2830 T9089 T9088 prep of,y
R2831 T9090 T9089 pobj age,of
R2832 T9091 T9086 punct ", ",sacrificed
R2833 T9092 T9093 det all,animals
R2834 T9093 T9086 nsubjpass animals,sacrificed
R2835 T9094 T9086 auxpass were,sacrificed
R2836 T9095 T9086 punct ", ",sacrificed
R2837 T9096 T9097 det the,auto-Abs
R2838 T9097 T9098 nsubj auto-Abs,assessed
R2839 T9098 T9086 conj assessed,sacrificed
R2840 T9099 T9098 punct ", ",assessed
R2841 T9100 T9098 cc and,assessed
R2842 T9101 T9102 det the,histology
R2843 T9102 T9104 nsubj histology,examined
R2844 T9103 T9102 amod renal,histology
R2845 T9104 T9098 conj examined,assessed
R2846 T9105 T9086 punct .,sacrificed
R2847 T9107 T9108 det The,results
R2848 T9108 T9109 nsubjpass results,shown
R2849 T9110 T9108 prep of,results
R2850 T9111 T9112 det this,analysis
R2851 T9112 T9110 pobj analysis,of
R2852 T9113 T9109 auxpass are,shown
R2853 T9114 T9109 prep in,shown
R2854 T9115 T9114 pobj Figure,in
R2855 T9116 T9115 nummod 8,Figure
R2856 T9117 T9109 punct .,shown
R2857 T9119 T9120 mark As,reported
R2858 T9120 T9122 advcl reported,increased
R2859 T9121 T9120 advmod previously,reported
R2860 T9123 T9124 punct (,Bickerstaff
R2861 T9124 T9122 meta Bickerstaff,increased
R2862 T9125 T9124 nmod et,Bickerstaff
R2863 T9126 T9124 nmod al.,Bickerstaff
R2864 T9127 T9124 nummod 1999,Bickerstaff
R2865 T9128 T9124 punct ),Bickerstaff
R2866 T9129 T9122 punct ", ",increased
R2867 T9130 T9131 det the,levels
R2868 T9131 T9122 nsubjpass levels,increased
R2869 T9132 T9131 prep of,levels
R2870 T9133 T9132 pobj auto-Abs,of
R2871 T9134 T9122 auxpass were,increased
R2872 T9135 T9122 advmod markedly,increased
R2873 T9136 T9122 prep in,increased
R2874 T9137 T9138 det the,C57BL
R2875 T9138 T9136 pobj C57BL,in
R2876 T9139 T9138 punct /,C57BL
R2877 T9140 T9138 nummod 6,C57BL
R2878 T9141 T9138 punct .,C57BL
R2879 T9142 T9138 appos Apcs,C57BL
R2880 T9143 T9142 punct −,Apcs
R2881 T9144 T9142 punct /,Apcs
R2882 T9145 T9142 punct −,Apcs
R2883 T9146 T9122 prep compared,increased
R2884 T9147 T9146 prep to,compared
R2885 T9148 T9149 det the,controls
R2886 T9149 T9147 pobj controls,to
R2887 T9150 T9151 amod wild,type
R2888 T9151 T9149 nmod type,controls
R2889 T9152 T9151 punct -,type
R2890 T9153 T9149 nmod C57BL,controls
R2891 T9154 T9153 punct /,C57BL
R2892 T9155 T9153 nummod 6,C57BL
R2893 T9156 T9122 punct .,increased
R2894 T9158 T9159 advmod However,expressed
R2895 T9160 T9159 punct ", ",expressed
R2896 T9161 T9162 det the,animals
R2897 T9162 T9159 nsubj animals,expressed
R2898 T9163 T9162 nmod C57BL,animals
R2899 T9164 T9163 punct /,C57BL
R2900 T9165 T9163 nummod 6,C57BL
R2901 T9166 T9163 punct .,C57BL
R2902 T9167 T9163 nummod 129,C57BL
R2903 T9168 T9163 punct (,C57BL
R2904 T9169 T9163 appos D1Mit105,C57BL
R2905 T9170 T9171 punct –,223
R2906 T9171 T9169 prep 223,D1Mit105
R2907 T9172 T9162 punct ),animals
R2908 T9173 T9159 advmod also,expressed
R2909 T9174 T9175 amod high,levels
R2910 T9175 T9159 dobj levels,expressed
R2911 T9176 T9175 prep of,levels
R2912 T9177 T9176 pobj auto-Abs,of
R2913 T9178 T9159 punct ", ",expressed
R2914 T9179 T9159 cc and,expressed
R2915 T9180 T9181 det these,titres
R2916 T9181 T9182 nsubj titres,were
R2917 T9182 T9159 conj were,expressed
R2918 T9183 T9182 neg not,were
R2919 T9184 T9182 acomp different,were
R2920 T9185 T9184 prep from,different
R2921 T9186 T9185 pobj those,from
R2922 T9187 T9186 acl detected,those
R2923 T9188 T9187 prep in,detected
R2924 T9189 T9190 det the,mice
R2925 T9190 T9188 pobj mice,in
R2926 T9191 T9190 amod matched,mice
R2927 T9192 T9190 amod congenic,mice
R2928 T9193 T9190 acl containing,mice
R2929 T9194 T9195 det a,mutation
R2930 T9195 T9193 dobj mutation,containing
R2931 T9196 T9195 amod null,mutation
R2932 T9197 T9195 prep of,mutation
R2933 T9198 T9199 det the,gene
R2934 T9199 T9197 pobj gene,of
R2935 T9200 T9199 compound Apcs,gene
R2936 T9201 T9182 punct .,were
R2937 T9203 T9204 det These,results
R2938 T9204 T9205 nsubj results,demonstrated
R2939 T9206 T9205 advmod clearly,demonstrated
R2940 T9207 T9208 mark that,were
R2941 T9208 T9205 ccomp were,demonstrated
R2942 T9209 T9210 amod epistatic,interactions
R2943 T9210 T9208 nsubj interactions,were
R2944 T9211 T9210 prep between,interactions
R2945 T9212 T9213 nummod 129,loci
R2946 T9213 T9211 pobj loci,between
R2947 T9214 T9213 prep on,loci
R2948 T9215 T9214 pobj Chromosome,on
R2949 T9216 T9215 nummod 1,Chromosome
R2950 T9217 T9213 cc and,loci
R2951 T9218 T9219 nmod C57BL,genes
R2952 T9219 T9213 conj genes,loci
R2953 T9220 T9218 punct /,C57BL
R2954 T9221 T9218 nummod 6,C57BL
R2955 T9222 T9208 acomp sufficient,were
R2956 T9223 T9224 aux to,mediate
R2957 T9224 T9222 xcomp mediate,sufficient
R2958 T9225 T9226 det the,loss
R2959 T9226 T9224 dobj loss,mediate
R2960 T9227 T9226 prep of,loss
R2961 T9228 T9227 pobj tolerance,of
R2962 T9229 T9228 prep to,tolerance
R2963 T9230 T9231 amod nuclear,autoantigens
R2964 T9231 T9229 pobj autoantigens,to
R2965 T9232 T9205 punct .,demonstrated
R2966 T9234 T9235 advmod However,showed
R2967 T9236 T9235 punct ", ",showed
R2968 T9237 T9235 prep in,showed
R2969 T9238 T9237 pobj contrast,in
R2970 T9239 T9238 prep to,contrast
R2971 T9240 T9241 det the,data
R2972 T9241 T9239 pobj data,to
R2973 T9242 T9241 amod serological,data
R2974 T9243 T9235 punct ", ",showed
R2975 T9244 T9245 det the,assessment
R2976 T9245 T9235 nsubj assessment,showed
R2977 T9246 T9245 amod histological,assessment
R2978 T9247 T9245 prep of,assessment
R2979 T9248 T9249 det the,kidneys
R2980 T9249 T9247 pobj kidneys,of
R2981 T9250 T9235 dobj evidence,showed
R2982 T9251 T9250 prep of,evidence
R2983 T9252 T9253 advmod markedly,glomerulonephritis
R2984 T9253 T9251 pobj glomerulonephritis,of
R2985 T9254 T9253 amod increased,glomerulonephritis
R2986 T9255 T9250 prep in,evidence
R2987 T9256 T9257 det the,C57BL
R2988 T9257 T9255 pobj C57BL,in
R2989 T9258 T9257 punct /,C57BL
R2990 T9259 T9257 nummod 6,C57BL
R2991 T9260 T9257 punct .,C57BL
R2992 T9261 T9257 appos Apcs,C57BL
R2993 T9262 T9261 punct −,Apcs
R2994 T9263 T9261 punct /,Apcs
R2995 T9264 T9261 punct −,Apcs
R2996 T9265 T9250 prep compared,evidence
R2997 T9266 T9265 prep to,compared
R2998 T9267 T9268 preconj both,groups
R2999 T9268 T9266 pobj groups,to
R3000 T9269 T9268 compound control,groups
R3001 T9270 T9271 punct (,Figure
R3002 T9271 T9268 parataxis Figure,groups
R3003 T9272 T9271 nummod 9,Figure
R3004 T9273 T9271 punct ),Figure
R3005 T9274 T9235 punct ", ",showed
R3006 T9275 T9235 advcl suggesting,showed
R3007 T9276 T9277 mark that,induce
R3008 T9277 T9275 ccomp induce,suggesting
R3009 T9278 T9279 det the,lack
R3010 T9279 T9277 nsubj lack,induce
R3011 T9280 T9279 prep of,lack
R3012 T9281 T9280 pobj Apcs,of
R3013 T9282 T9277 punct ", ",induce
R3014 T9283 T9284 advmod when,combined
R3015 T9284 T9277 advcl combined,induce
R3016 T9285 T9284 prep with,combined
R3017 T9286 T9287 amod other,alleles
R3018 T9287 T9285 pobj alleles,with
R3019 T9288 T9287 nmod C57BL,alleles
R3020 T9289 T9288 punct /,C57BL
R3021 T9290 T9288 nummod 6,C57BL
R3022 T9291 T9287 compound susceptibility,alleles
R3023 T9292 T9277 punct ", ",induce
R3024 T9293 T9277 aux can,induce
R3025 T9294 T9295 det the,development
R3026 T9295 T9277 dobj development,induce
R3027 T9296 T9295 prep of,development
R3028 T9297 T9298 amod severe,damage
R3029 T9298 T9296 pobj damage,of
R3030 T9299 T9298 amod renal,damage
R3031 T9300 T9235 punct .,showed
R3040 T13555 T13556 expl There,is
R3042 T13557 T13558 amod accumulating,evidence
R3044 T13558 T13556 attr evidence,is
R3045 T13559 T13560 mark that,influence
R3046 T13560 T13558 acl influence,evidence
R3048 T13561 T13562 compound background,genes
R3049 T13562 T13560 nsubj genes,influence
R3050 T13563 T13560 aux may,influence
R3051 T13564 T13565 det the,expression
R3052 T13565 T13560 dobj expression,influence
R3053 T13566 T13565 prep of,expression
R3054 T13567 T13566 pobj autoimmunity,of
R3055 T13568 T13560 prep in,influence
R3056 T13569 T13570 npadvmod gene,targeted
R3057 T13570 T13572 amod targeted,mice
R3058 T13571 T13570 punct -,targeted
R3059 T13572 T13568 pobj mice,in
R3060 T13573 T13556 punct .,is
R3061 T13575 T13576 advmod Here,report
R3062 T13577 T13576 nsubj we,report
R3063 T13578 T13579 dep what,is
R3064 T13579 T13576 ccomp is,report
R3066 T13580 T13579 prep to,is
R3067 T13581 T13582 poss our,knowledge
R3068 T13582 T13580 pobj knowledge,to
R3069 T13583 T13584 det the,study
R3070 T13584 T13579 attr study,is
R3071 T13585 T13584 amod first,study
R3072 T13586 T13584 amod systematic,study
R3073 T13587 T13588 dep that,examined
R3074 T13588 T13584 relcl examined,study
R3075 T13589 T13588 aux has,examined
R3076 T13590 T13588 dobj this,examined
R3077 T13591 T13588 prep in,examined
R3078 T13592 T13593 det the,strains
R3079 T13593 T13591 pobj strains,in
R3080 T13594 T13593 nummod 129,strains
R3081 T13595 T13594 cc and,129
R3082 T13596 T13594 conj C57BL,129
R3083 T13600 T13593 punct ", ",strains
R3084 T13597 T13596 punct /,C57BL
R3085 T13601 T13602 advmod widely,used
R3086 T13602 T13593 acl used,strains
R3087 T13598 T13596 nummod 6,C57BL
R3088 T13603 T13602 prep for,used
R3089 T13604 T13605 compound gene,targeting
R3090 T13605 T13603 pobj targeting,for
R3091 T13599 T13593 compound mouse,strains
R3092 T13606 T13576 punct .,report
R3093 T13608 T13609 poss Our,results
R3094 T13706 T13699 dobj severity,influences
R3095 T13609 T13610 nsubj results,demonstrate
R3096 T13611 T13612 amod interacting,loci
R3097 T13707 T13706 prep of,severity
R3098 T13612 T13610 dobj loci,demonstrate
R3099 T13613 T13612 prep between,loci
R3100 T13614 T13615 nummod 129,mice
R3101 T13708 T13707 pobj glomerulonephritis,of
R3102 T13615 T13613 pobj mice,between
R3103 T13616 T13614 cc and,129
R3104 T13709 T13699 punct ", ",influences
R3105 T13617 T13614 conj C57BL,129
R3106 T13618 T13617 punct /,C57BL
R3107 T13619 T13617 nummod 6,C57BL
R3108 T13710 T13699 cc but,influences
R3109 T13620 T13621 dep that,cause
R3110 T13621 T13612 relcl cause,loci
R3111 T13622 T13621 aux can,cause
R3112 T13711 T13699 conj is,influences
R3113 T13623 T13624 det the,expression
R3114 T13624 T13621 dobj expression,cause
R3115 T13625 T13624 prep of,expression
R3116 T13712 T13711 neg not,is
R3117 T13626 T13627 det a,phenotype
R3118 T13627 T13625 pobj phenotype,of
R3119 T13713 T13714 det the,mover
R3120 T13628 T13627 amod powerful,phenotype
R3121 T13629 T13627 amod autoimmune,phenotype
R3122 T13630 T13621 prep in,cause
R3123 T13714 T13711 attr mover,is
R3124 T13631 T13632 det these,animals
R3125 T13632 T13630 pobj animals,in
R3126 T13633 T13621 punct ", ",cause
R3127 T13715 T13714 amod prime,mover
R3128 T13634 T13621 prep in,cause
R3129 T13716 T13711 prep in,is
R3130 T13717 T13718 det the,induction
R3131 T13635 T13636 det the,absence
R3132 T13636 T13634 pobj absence,in
R3133 T13718 T13716 pobj induction,in
R3134 T13637 T13636 prep of,absence
R3135 T13638 T13639 det any,mutations
R3136 T13639 T13637 pobj mutations,of
R3137 T13640 T13641 npadvmod gene,targeted
R3138 T13641 T13639 amod targeted,mutations
R3139 T13642 T13641 punct -,targeted
R3140 T13719 T13718 prep of,induction
R3141 T13643 T13610 punct .,demonstrate
R3142 T13720 T13721 amod anti-nuclear,autoimmunity
R3143 T13645 T13646 nsubj We,developed
R3144 T13647 T13646 advmod also,developed
R3145 T13721 T13719 pobj autoimmunity,of
R3146 T13648 T13649 det a,strain
R3147 T13649 T13646 dobj strain,developed
R3148 T13722 T13711 punct ", ",is
R3149 T13650 T13649 amod congenic,strain
R3150 T13651 T13649 compound mouse,strain
R3151 T13652 T13649 acl bearing,strain
R3152 T13723 T13711 advcl contrary,is
R3153 T13653 T13654 det a,portion
R3154 T13654 T13652 dobj portion,bearing
R3155 T13655 T13654 prep of,portion
R3156 T13724 T13723 prep to,contrary
R3157 T13656 T13657 nummod 129,Chromosome
R3158 T13657 T13655 pobj Chromosome,of
R3159 T13725 T13726 poss our,interpretation
R3160 T13658 T13657 nummod 1,Chromosome
R3161 T13659 T13652 prep on,bearing
R3162 T13660 T13661 det a,background
R3163 T13726 T13724 pobj interpretation,to
R3164 T13661 T13659 pobj background,on
R3165 T13662 T13661 nmod C57BL,background
R3166 T13663 T13662 punct /,C57BL
R3167 T13727 T13726 amod own,interpretation
R3168 T13664 T13662 nummod 6,C57BL
R3169 T13728 T13726 amod original,interpretation
R3170 T13665 T13646 cc and,developed
R3171 T13666 T13646 conj showed,developed
R3172 T13667 T13668 mark that,expressed
R3173 T13668 T13666 ccomp expressed,showed
R3174 T13729 T13726 prep of,interpretation
R3175 T13669 T13670 det this,line
R3176 T13670 T13668 nsubj line,expressed
R3177 T13671 T13672 amod wild,type
R3178 T13672 T13670 nmod type,line
R3179 T13730 T13731 poss our,data
R3180 T13673 T13672 punct -,type
R3181 T13674 T13670 amod congenic,line
R3182 T13675 T13676 amod striking,autoimmunity
R3183 T13731 T13729 pobj data,of
R3184 T13676 T13668 dobj autoimmunity,expressed
R3185 T13677 T13676 amod anti-nuclear,autoimmunity
R3186 T13678 T13646 punct .,developed
R3187 T13680 T13681 prep By,demonstrated
R3188 T13732 T13733 punct (,Bickerstaff
R3189 T13682 T13680 pcomp comparing,By
R3190 T13683 T13684 det this,strain
R3191 T13684 T13682 dobj strain,comparing
R3193 T13685 T13684 nmod Chromosome,strain
R3194 T13686 T13685 nummod 1,Chromosome
R3195 T13687 T13684 amod congenic,strain
R3196 T13734 T13733 nmod et,Bickerstaff
R3197 T13688 T13682 prep with,comparing
R3198 T13689 T13690 amod matched,mice
R3199 T13690 T13688 pobj mice,with
R3200 T13735 T13733 nmod al.,Bickerstaff
R3201 T13691 T13690 amod congenic,mice
R3202 T13692 T13690 acl lacking,mice
R3203 T13693 T13694 det the,gene
R3204 T13736 T13733 nummod 1999,Bickerstaff
R3205 T13694 T13692 dobj gene,lacking
R3206 T13695 T13694 compound Apcs,gene
R3207 T13696 T13681 punct ", ",demonstrated
R3208 T13737 T13733 punct ),Bickerstaff
R3209 T13697 T13681 nsubj we,demonstrated
R3210 T13698 T13699 mark that,influences
R3211 T13738 T13681 punct .,demonstrated
R3212 T13699 T13681 ccomp influences,demonstrated
R3213 T13700 T13701 compound serum,component
R3214 T13701 T13704 compound component,deficiency
R3215 T13740 T13741 det The,consideration
R3216 T13702 T13701 compound amyloid,component
R3217 T13703 T13701 compound P,component
R3218 T13704 T13699 nsubj deficiency,influences
R3219 T13705 T13706 det the,severity
R3220 T13741 T13743 nsubj consideration,applies
R3221 T13742 T13741 amod same,consideration
R3222 T13744 T13743 prep to,applies
R3223 T13745 T13746 amod other,genes
R3224 T13812 T13810 pcomp is,to
R3225 T13813 T13814 det the,autoimmunity
R3226 T13746 T13744 pobj genes,to
R3227 T13814 T13812 nsubj autoimmunity,is
R3228 T13815 T13814 amod anti-nuclear,autoimmunity
R3229 T13816 T13812 prep due,is
R3230 T13747 T13746 acl located,genes
R3231 T13817 T13816 prep to,due
R3232 T13818 T13819 det the,gene
R3233 T13748 T13747 prep in,located
R3234 T13819 T13817 pobj gene,to
R3235 T13820 T13821 npadvmod gene,targeted
R3236 T13821 T13819 amod targeted,gene
R3237 T13749 T13750 det the,region
R3238 T13822 T13821 punct -,targeted
R3239 T13823 T13819 compound mutant,gene
R3240 T13824 T13817 cc or,to
R3241 T13825 T13817 conj to,to
R3242 T13826 T13827 det the,genes
R3243 T13827 T13825 pobj genes,to
R3244 T13750 T13748 pobj region,in
R3245 T13828 T13827 amod normal,genes
R3246 T13829 T13827 nummod 129,genes
R3247 T13830 T13827 acl expressed,genes
R3248 T13751 T13750 amod same,region
R3249 T13831 T13830 prep in,expressed
R3250 T13832 T13833 det the,region
R3251 T13833 T13831 pobj region,in
R3252 T13752 T13750 nmod Chromosome,region
R3253 T13834 T13833 amod same,region
R3254 T13835 T13833 prep as,region
R3255 T13753 T13752 nummod 1,Chromosome
R3256 T13836 T13837 det the,gene
R3257 T13837 T13835 pobj gene,as
R3258 T13838 T13837 amod targeted,gene
R3259 T13754 T13755 dep that,implicated
R3260 T13839 T13801 punct .,has
R3261 T13755 T13746 relcl implicated,genes
R3262 T13841 T13842 det The,influence
R3263 T13842 T13843 nsubj influence,is
R3264 T13756 T13755 aux have,implicated
R3265 T13844 T13842 prep of,influence
R3266 T13845 T13846 compound background,genes
R3267 T13757 T13755 auxpass been,implicated
R3268 T13846 T13844 pobj genes,of
R3269 T13847 T13842 prep on,influence
R3270 T13848 T13849 det the,development
R3271 T13758 T13755 prep in,implicated
R3272 T13849 T13847 pobj development,on
R3273 T13850 T13849 prep of,development
R3274 T13851 T13852 amod spontaneous,disease
R3275 T13759 T13760 det the,development
R3276 T13852 T13850 pobj disease,of
R3277 T13853 T13852 amod autoimmune,disease
R3278 T13760 T13758 pobj development,in
R3279 T13854 T13855 advmod well,known
R3280 T13855 T13843 acomp known,is
R3281 T13856 T13843 punct ", ",is
R3282 T13761 T13760 prep of,development
R3283 T13857 T13858 advmod especially,with
R3284 T13858 T13843 prep with,is
R3285 T13762 T13761 pobj SLE,of
R3286 T13859 T13858 pobj respect,with
R3287 T13860 T13859 prep to,respect
R3288 T13861 T13862 det the,genes
R3289 T13763 T13764 advmod when,inactivated
R3290 T13862 T13860 pobj genes,to
R3291 T13863 T13862 nmod lpr,genes
R3292 T13864 T13863 cc and,lpr
R3293 T13865 T13863 conj Yaa,lpr
R3294 T13866 T13867 compound disease,susceptibility
R3295 T13764 T13755 advcl inactivated,implicated
R3296 T13867 T13862 compound susceptibility,genes
R3297 T13868 T13867 punct -,susceptibility
R3298 T13869 T13843 punct .,is
R3299 T13765 T13764 agent by,inactivated
R3300 T13871 T13872 prep In,accelerates
R3301 T13766 T13765 pobj gene,by
R3302 T13873 T13874 compound MRL,Mp
R3303 T13874 T13876 compound Mp,mice
R3304 T13767 T13766 punct -,gene
R3305 T13875 T13874 punct /,Mp
R3306 T13876 T13871 pobj mice,In
R3307 T13877 T13872 punct ", ",accelerates
R3308 T13768 T13766 amod targeting,gene
R3309 T13878 T13879 det the,presence
R3310 T13879 T13872 nsubj presence,accelerates
R3311 T13880 T13879 prep of,presence
R3312 T13769 T13764 prep in,inactivated
R3313 T13881 T13882 det the,gene
R3314 T13882 T13880 pobj gene,of
R3315 T13883 T13882 compound lpr,gene
R3316 T13770 T13771 nummod 129,cells
R3317 T13884 T13885 det the,development
R3318 T13885 T13872 dobj development,accelerates
R3319 T13886 T13885 prep of,development
R3320 T13771 T13769 pobj cells,in
R3321 T13887 T13888 amod high,level
R3322 T13888 T13889 nmod level,production
R3323 T13772 T13771 amod embryonic,cells
R3324 T13773 T13771 compound stem,cells
R3325 T13889 T13886 pobj production,of
R3326 T13890 T13888 cc and,level
R3327 T13891 T13892 compound broad,spectrum
R3328 T13774 T13764 cc and,inactivated
R3329 T13892 T13888 conj spectrum,level
R3330 T13893 T13892 punct -,spectrum
R3331 T13775 T13776 advmod then,backcrossed
R3332 T13894 T13889 compound auto-Ab,production
R3333 T13895 T13889 cc and,production
R3334 T13776 T13764 conj backcrossed,inactivated
R3335 T13896 T13897 amod lethal,glomerulonephritis
R3336 T13897 T13889 conj glomerulonephritis,production
R3337 T13898 T13889 punct ", ",production
R3338 T13777 T13776 prep onto,backcrossed
R3339 T13899 T13889 prep in,production
R3340 T13900 T13899 pobj addition,in
R3341 T13778 T13779 det a,background
R3342 T13901 T13900 prep to,addition
R3343 T13902 T13903 amod marked,disease
R3344 T13903 T13901 pobj disease,to
R3345 T13904 T13903 amod lymphoproliferative,disease
R3346 T13905 T13872 punct .,accelerates
R3347 T13779 T13777 pobj background,onto
R3348 T13907 T13908 prep In,leads
R3349 T13780 T13779 amod pure,background
R3350 T13909 T13907 pobj contrast,In
R3351 T13910 T13908 punct ", ",leads
R3352 T13911 T13908 nsubj homozygosity,leads
R3353 T13781 T13779 amod genetic,background
R3354 T13912 T13911 prep of,homozygosity
R3355 T13913 T13914 det the,gene
R3356 T13782 T13783 punct (,Bolland
R3357 T13914 T13912 pobj gene,of
R3358 T13915 T13914 compound lpr,gene
R3359 T13916 T13911 prep in,homozygosity
R3360 T13783 T13764 meta Bolland,inactivated
R3361 T13917 T13918 amod other,strains
R3362 T13784 T13783 cc and,Bolland
R3363 T13785 T13783 conj Ravetch,Bolland
R3364 T13786 T13785 nummod 2000,Ravetch
R3365 T13918 T13916 pobj strains,in
R3366 T13919 T13920 amod such,as
R3367 T13787 T13785 punct ;,Ravetch
R3368 T13920 T13918 prep as,strains
R3369 T13921 T13920 pobj C57BL,as
R3370 T13922 T13921 punct /,C57BL
R3371 T13788 T13785 conj Miwa,Ravetch
R3374 T13789 T13788 nmod et,Miwa
R3375 T13925 T13921 conj AKR,C57BL
R3376 T13926 T13925 punct ", ",AKR
R3377 T13927 T13928 compound LG,J
R3378 T13790 T13788 nmod al.,Miwa
R3379 T13928 T13925 conj J,AKR
R3380 T13929 T13928 punct /,J
R3381 T13930 T13928 punct ", ",J
R3382 T13791 T13788 nummod 2002,Miwa
R3383 T13931 T13928 cc and,J
R3384 T13932 T13928 conj C3H,J
R3385 T13792 T13788 punct ;,Miwa
R3386 T13933 T13908 advmod only,leads
R3387 T13934 T13908 prep to,leads
R3388 T13935 T13936 compound auto-Ab,production
R3389 T13793 T13788 conj Wu,Miwa
R3390 T13936 T13934 pobj production,to
R3391 T13794 T13793 nmod et,Wu
R3392 T13795 T13793 nmod al.,Wu
R3393 T13937 T13938 punct (,Izui
R3394 T13938 T13908 meta Izui,leads
R3395 T13939 T13938 nmod et,Izui
R3396 T13940 T13938 nmod al.,Izui
R3397 T13941 T13938 nummod 1984,Izui
R3398 T13796 T13793 nummod 2002,Wu
R3399 T13942 T13938 punct ),Izui
R3400 T13943 T13908 punct .,leads
R3401 T13797 T13793 punct ),Wu
R3402 T13945 T13946 advmod Similarly,enhances
R3403 T13798 T13743 punct .,applies
R3404 T13947 T13946 punct ", ",enhances
R3405 T13948 T13949 det the,gene
R3406 T13949 T13946 nsubj gene,enhances
R3407 T13800 T13801 prep For,has
R3408 T13950 T13951 compound Y,chromosome
R3409 T13951 T13953 npadvmod chromosome,linked
R3410 T13952 T13951 punct -,chromosome
R3411 T13953 T13949 amod linked,gene
R3412 T13802 T13800 pobj each,For
R3413 T13954 T13953 punct -,linked
R3414 T13955 T13949 compound Yaa,gene
R3415 T13956 T13949 prep in,gene
R3416 T13957 T13958 nmod BXSB,males
R3417 T13803 T13801 punct ", ",has
R3418 T13958 T13956 pobj males,in
R3419 T13959 T13957 cc and,BXSB
R3420 T13960 T13961 compound MRL,Mp
R3421 T13804 T13801 expl there,has
R3422 T13961 T13957 conj Mp,BXSB
R3423 T13962 T13961 punct /,Mp
R3424 T13963 T13964 det the,development
R3425 T13805 T13806 aux to,be
R3426 T13964 T13946 dobj development,enhances
R3427 T13965 T13964 amod rapid,development
R3428 T13966 T13964 prep of,development
R3429 T13806 T13801 xcomp be,has
R3430 T13967 T13966 pobj auto-Abs,of
R3431 T13968 T13967 cc and,auto-Abs
R3432 T13969 T13967 conj glomerulonephritis,auto-Abs
R3433 T13807 T13808 det a,question
R3434 T13970 T13971 punct (,Izui
R3435 T13971 T13946 meta Izui,enhances
R3436 T13972 T13971 nmod et,Izui
R3437 T13808 T13806 attr question,be
R3438 T13973 T13971 nmod al.,Izui
R3439 T13809 T13808 prep as,question
R3440 T13810 T13809 prep to,as
R3441 T13974 T13971 nummod 1988,Izui
R3442 T13975 T13971 punct ;,Izui
R3443 T13811 T13812 mark whether,is
R3444 T13976 T13971 nmod Merino,Izui
R3445 T13977 T13971 nmod et,Izui
R3446 T13978 T13971 nmod al.,Izui
R3447 T13979 T13971 nummod 1989,Izui
R3448 T13980 T13971 punct ),Izui
R3449 T14023 T14022 prep of,expression
R3450 T13981 T13946 punct .,enhances
R3451 T13983 T13984 advmod However,lead
R3452 T13985 T13984 punct ", ",lead
R3453 T14024 T14023 pobj autoimmunity,of
R3454 T13986 T13984 prep in,lead
R3455 T13987 T13988 det the,background
R3456 T13988 T13986 pobj background,in
R3457 T14025 T14012 aux have,reported
R3458 T13989 T13988 nmod C57BL,background
R3459 T13990 T13989 punct /,C57BL
R3460 T14026 T14012 advmod also,reported
R3461 T13991 T13989 nummod 6,C57BL
R3462 T13992 T13984 punct ", ",lead
R3463 T13993 T13994 det the,gene
R3464 T14027 T14012 auxpass been,reported
R3465 T13994 T13984 nsubj gene,lead
R3466 T13995 T13994 compound Yaa,gene
R3467 T13996 T13984 aux does,lead
R3468 T14028 T14012 prep in,reported
R3469 T13997 T13984 neg not,lead
R3470 T13998 T13984 prep to,lead
R3471 T13999 T14000 det an,phenotype
R3473 T14000 T13998 pobj phenotype,to
R3474 T14001 T14000 amod autoimmune,phenotype
R3475 T14002 T14003 punct (,Izui
R3476 T14030 T14032 amod targeted,mice
R3477 T14003 T13984 meta Izui,lead
R3478 T14004 T14003 nmod et,Izui
R3479 T14005 T14003 nmod al.,Izui
R3480 T14031 T14030 punct -,targeted
R3481 T14006 T14003 nummod 1988,Izui
R3482 T14007 T14003 punct ),Izui
R3483 T14008 T13984 punct .,lead
R3484 T14032 T14028 pobj mice,in
R3485 T14010 T14011 neg Not,surprisingly
R3486 T14033 T14034 punct (,Bolland
R3487 T14011 T14012 advmod surprisingly,reported
R3488 T14034 T14012 meta Bolland,reported
R3489 T14013 T14012 punct ", ",reported
R3490 T14014 T14015 amod important,effects
R3491 T14015 T14012 nsubjpass effects,reported
R3492 T14035 T14034 cc and,Bolland
R3493 T14016 T14015 prep of,effects
R3494 T14017 T14018 det the,background
R3495 T14036 T14034 conj Ravetch,Bolland
R3496 T14018 T14016 pobj background,of
R3497 T14019 T14018 amod genetic,background
R3498 T14020 T14015 prep on,effects
R3499 T14021 T14022 det the,expression
R3500 T14022 T14020 pobj expression,on
R3501 T14037 T14036 nummod 2000,Ravetch
R3502 T14038 T14036 punct ;,Ravetch
R3503 T14039 T14036 conj Santiago,Ravetch
R3504 T14129 T14125 relcl depended,pattern
R3505 T14040 T14039 punct -,Santiago
R3506 T14130 T14128 pobj which,in
R3507 T14131 T14132 det a,phenotype
R3508 T14132 T14129 nsubj phenotype,depended
R3509 T14041 T14039 nmod Raber,Santiago
R3510 T14133 T14132 amod positive,phenotype
R3511 T14042 T14039 nmod et,Santiago
R3512 T14134 T14129 prep upon,depended
R3513 T14043 T14039 nmod al.,Santiago
R3514 T14135 T14136 det the,presence
R3515 T14136 T14134 pobj presence,upon
R3516 T14137 T14136 prep of,presence
R3517 T14044 T14039 nummod 2001,Santiago
R3518 T14138 T14139 amod multiple,loci
R3519 T14139 T14137 pobj loci,of
R3520 T14045 T14039 punct ;,Santiago
R3521 T14140 T14139 amod discrete,loci
R3522 T14141 T14139 compound susceptibility,loci
R3523 T14142 T14129 prep with,depended
R3524 T14046 T14039 conj Mitchell,Santiago
R3525 T14143 T14144 det no,locus
R3526 T14144 T14146 nsubj locus,being
R3527 T14145 T14144 amod single,locus
R3528 T14047 T14046 nmod et,Mitchell
R3529 T14146 T14142 pcomp being,with
R3530 T14147 T14148 det a,factor
R3531 T14148 T14146 attr factor,being
R3532 T14048 T14046 nmod al.,Mitchell
R3533 T14149 T14148 amod prerequisite,factor
R3534 T14150 T14108 punct .,shown
R3535 T14049 T14046 nummod 2002,Mitchell
R3536 T14152 T14153 nsubj We,employed
R3537 T14050 T14046 punct ),Mitchell
R3538 T14154 T14153 aux have,employed
R3539 T14155 T14156 det the,approach
R3540 T14156 T14153 dobj approach,employed
R3541 T14051 T14012 punct .,reported
R3542 T14157 T14156 amod same,approach
R3543 T14158 T14159 aux to,analyse
R3544 T14159 T14153 advcl analyse,employed
R3545 T14053 T14054 advmod Thus,exists
R3546 T14160 T14161 det the,basis
R3547 T14161 T14159 dobj basis,analyse
R3548 T14162 T14161 amod genetic,basis
R3549 T14163 T14161 prep of,basis
R3550 T14164 T14165 compound disease,inheritance
R3551 T14165 T14163 pobj inheritance,of
R3552 T14166 T14161 prep in,basis
R3553 T14055 T14054 punct ", ",exists
R3554 T14167 T14168 det the,strain
R3555 T14168 T14166 pobj strain,in
R3556 T14169 T14168 punct (,strain
R3557 T14170 T14168 nummod 129,strain
R3558 T14056 T14054 nsubj SLE,exists
R3559 T14171 T14170 punct ×,129
R3560 T14172 T14170 appos C57BL,129
R3561 T14173 T14172 punct /,C57BL
R3562 T14057 T14054 prep as,exists
R3563 T14174 T14172 nummod 6,C57BL
R3564 T14175 T14168 punct ),strain
R3565 T14058 T14059 det a,disorder
R3566 T14176 T14168 compound hybrid,strain
R3567 T14177 T14168 punct ", ",strain
R3568 T14178 T14179 det the,background
R3569 T14059 T14057 pobj disorder,as
R3570 T14179 T14168 appos background,strain
R3571 T14180 T14181 advmod most,common
R3572 T14181 T14179 amod common,background
R3573 T14060 T14061 amod complex,trait
R3574 T14182 T14179 amod genetic,background
R3575 T14183 T14179 prep in,background
R3576 T14184 T14185 npadvmod gene,targeted
R3577 T14061 T14059 compound trait,disorder
R3578 T14185 T14187 amod targeted,mice
R3579 T14186 T14185 punct -,targeted
R3580 T14187 T14183 pobj mice,in
R3581 T14062 T14061 punct -,trait
R3582 T14188 T14153 punct .,employed
R3583 T14063 T14064 prep in,required
R3584 T14190 T14191 mark Although,documented
R3585 T14191 T14197 advcl documented,described
R3586 T14192 T14193 amod spontaneous,autoimmunity
R3587 T14064 T14059 relcl required,disorder
R3588 T14193 T14191 nsubjpass autoimmunity,documented
R3589 T14194 T14191 aux has,documented
R3590 T14195 T14191 neg not,documented
R3591 T14065 T14063 pobj which,in
R3592 T14196 T14191 auxpass been,documented
R3593 T14066 T14067 amod specific,combinations
R3594 T14198 T14191 prep in,documented
R3595 T14199 T14198 pobj either,in
R3596 T14200 T14199 prep of,either
R3597 T14067 T14064 nsubjpass combinations,required
R3598 T14201 T14202 det the,strains
R3599 T14202 T14200 pobj strains,of
R3600 T14068 T14067 prep of,combinations
R3601 T14203 T14202 amod pure,strains
R3602 T14204 T14202 nummod 129,strains
R3603 T14205 T14204 cc or,129
R3604 T14206 T14204 conj C57BL,129
R3605 T14207 T14206 punct /,C57BL
R3606 T14069 T14070 compound susceptibility,alleles
R3607 T14208 T14206 nummod 6,C57BL
R3608 T14209 T14197 punct ", ",described
R3609 T14070 T14068 pobj alleles,of
R3610 T14210 T14211 det a,phenotype
R3611 T14211 T14197 nsubjpass phenotype,described
R3612 T14212 T14211 amod spontaneous,phenotype
R3613 T14071 T14064 auxpass are,required
R3614 T14213 T14214 npadvmod lupus,like
R3615 T14214 T14211 amod like,phenotype
R3616 T14215 T14214 punct -,like
R3617 T14072 T14064 prep for,required
R3618 T14216 T14197 aux has,described
R3619 T14217 T14197 auxpass been,described
R3620 T14218 T14197 prep in,described
R3621 T14073 T14074 det the,expression
R3622 T14074 T14072 pobj expression,for
R3623 T14219 T14220 punct (,strains
R3624 T14220 T14218 pobj strains,in
R3625 T14075 T14074 prep of,expression
R3626 T14221 T14220 nummod 129,strains
R3627 T14222 T14221 punct ×,129
R3628 T14223 T14221 appos C57BL,129
R3629 T14076 T14077 det the,phenotype
R3630 T14224 T14223 punct /,C57BL
R3631 T14225 T14223 nummod 6,C57BL
R3632 T14077 T14075 pobj phenotype,of
R3633 T14226 T14220 punct ),strains
R3634 T14227 T14220 compound hybrid,strains
R3635 T14228 T14229 punct (,Obata
R3636 T14078 T14077 amod full,phenotype
R3637 T14229 T14197 meta Obata,described
R3638 T14230 T14229 nmod et,Obata
R3639 T14231 T14229 nmod al.,Obata
R3640 T14079 T14054 punct .,exists
R3641 T14232 T14229 nummod 1979,Obata
R3642 T14233 T14229 punct ;,Obata
R3643 T14234 T14229 nmod Botto,Obata
R3644 T14081 T14082 prep Through,made
R3645 T14083 T14084 det the,use
R3646 T14235 T14229 nmod et,Obata
R3647 T14236 T14229 nmod al.,Obata
R3648 T14084 T14081 pobj use,Through
R3649 T14237 T14229 nummod 1998,Obata
R3650 T14238 T14229 punct ;,Obata
R3651 T14239 T14229 nmod Bickerstaff,Obata
R3652 T14085 T14084 prep of,use
R3653 T14240 T14229 nmod et,Obata
R3654 T14241 T14229 nmod al.,Obata
R3655 T14242 T14229 nummod 1999,Obata
R3656 T14243 T14229 punct ;,Obata
R3657 T14244 T14229 nmod Santiago,Obata
R3658 T14245 T14229 punct -,Obata
R3659 T14086 T14087 compound microsatellite,maps
R3660 T14246 T14229 nmod Raber,Obata
R3661 T14247 T14229 nmod et,Obata
R3662 T14248 T14229 nmod al.,Obata
R3663 T14087 T14085 pobj maps,of
R3664 T14249 T14229 nummod 2001,Obata
R3665 T14250 T14229 punct ),Obata
R3666 T14088 T14087 compound marker,maps
R3667 T14251 T14197 punct ", ",described
R3668 T14252 T14197 advcl suggesting,described
R3669 T14089 T14082 punct ", ",made
R3670 T14253 T14254 mark that,arise
R3671 T14254 T14252 ccomp arise,suggesting
R3672 T14255 T14256 det the,predisposition
R3673 T14090 T14091 det the,identification
R3674 T14256 T14254 nsubj predisposition,arise
R3675 T14257 T14256 prep in,predisposition
R3676 T14258 T14259 det these,mice
R3677 T14091 T14082 nsubjpass identification,made
R3678 T14259 T14257 pobj mice,in
R3679 T14260 T14259 amod hybrid,mice
R3680 T14261 T14254 aux may,arise
R3681 T14092 T14091 prep of,identification
R3682 T14262 T14254 prep as,arise
R3683 T14263 T14264 det a,result
R3684 T14093 T14094 amod murine,intervals
R3685 T14264 T14262 pobj result,as
R3686 T14265 T14264 prep of,result
R3687 T14266 T14267 det the,interaction
R3688 T14094 T14092 pobj intervals,of
R3689 T14267 T14265 pobj interaction,of
R3690 T14268 T14267 prep between,interaction
R3691 T14269 T14270 amod specific,combinations
R3692 T14095 T14096 compound SLE,susceptibility
R3693 T14270 T14268 pobj combinations,between
R3694 T14271 T14270 prep of,combinations
R3695 T14272 T14271 pobj alleles,of
R3696 T14096 T14094 compound susceptibility,intervals
R3697 T14273 T14272 acl inherited,alleles
R3698 T14274 T14273 prep from,inherited
R3699 T14097 T14091 prep in,identification
R3700 T14275 T14276 preconj both,strains
R3701 T14276 T14274 pobj strains,from
R3702 T14277 T14276 det the,strains
R3703 T14098 T14099 amod experimental,crosses
R3704 T14278 T14276 nummod 129,strains
R3705 T14279 T14278 cc and,129
R3706 T14280 T14278 conj C57BL,129
R3707 T14281 T14280 punct /,C57BL
R3708 T14282 T14280 nummod 6,C57BL
R3709 T14099 T14097 pobj crosses,in
R3710 T14283 T14276 amod parental,strains
R3711 T14284 T14197 punct .,described
R3712 T14100 T14082 aux has,made
R3713 T14286 T14287 nsubjpass This,confirmed
R3714 T14288 T14287 auxpass was,confirmed
R3715 T14101 T14082 auxpass been,made
R3716 T14289 T14287 agent by,confirmed
R3717 T14102 T14082 oprd possible,made
R3718 T14290 T14291 det the,study
R3719 T14291 T14289 pobj study,by
R3720 T14292 T14291 compound mapping,study
R3721 T14293 T14291 acl reported,study
R3722 T14103 T14082 punct .,made
R3723 T14294 T14293 advmod here,reported
R3724 T14295 T14287 punct .,confirmed
R3725 T14105 T14106 det These,studies
R3726 T14297 T14298 nsubj We,showed
R3727 T14299 T14300 mark that,are
R3728 T14300 T14298 ccomp are,showed
R3729 T14106 T14108 nsubj studies,shown
R3730 T14301 T14300 expl there,are
R3732 T14107 T14106 compound mapping,studies
R3733 T14109 T14108 aux have,shown
R3734 T14303 T14300 attr loci,are
R3735 T14304 T14303 amod genetic,loci
R3736 T14305 T14303 acl contributing,loci
R3737 T14306 T14305 prep to,contributing
R3738 T14110 T14111 mark that,followed
R3739 T14307 T14308 det the,disease
R3740 T14308 T14306 pobj disease,to
R3741 T14111 T14108 ccomp followed,shown
R3742 T14309 T14298 cc and,showed
R3743 T14310 T14311 nsubjpass these,derived
R3744 T14311 T14298 conj derived,showed
R3745 T14112 T14113 det the,expression
R3746 T14312 T14311 auxpass are,derived
R3747 T14313 T14311 prep from,derived
R3748 T14113 T14111 nsubj expression,followed
R3749 T14314 T14315 preconj both,129
R3750 T14315 T14316 nummod 129,mice
R3751 T14114 T14113 compound disease,expression
R3752 T14316 T14313 pobj mice,from
R3753 T14317 T14315 cc and,129
R3754 T14318 T14315 conj C57BL,129
R3755 T14115 T14113 prep in,expression
R3756 T14319 T14318 punct /,C57BL
R3757 T14320 T14318 nummod 6,C57BL
R3758 T14321 T14311 punct .,derived
R3759 T14323 T14324 nsubj We,demonstrated
R3760 T14116 T14115 pobj relation,in
R3761 T14117 T14116 prep to,relation
R3762 T14325 T14326 mark that,was
R3763 T14118 T14119 det the,inheritance
R3764 T14326 T14324 ccomp was,demonstrated
R3765 T14327 T14328 det a,segment
R3766 T14119 T14117 pobj inheritance,to
R3767 T14328 T14326 nsubj segment,was
R3768 T14329 T14330 advmod 129,derived
R3769 T14330 T14328 amod derived,segment
R3770 T14120 T14119 prep of,inheritance
R3771 T14331 T14330 punct -,derived
R3772 T14332 T14328 prep of,segment
R3773 T14333 T14332 pobj Chromosome,of
R3774 T14121 T14122 det the,alleles
R3775 T14334 T14333 nummod 1,Chromosome
R3776 T14335 T14336 advmod strongly,linked
R3777 T14122 T14120 pobj alleles,of
R3778 T14336 T14326 acomp linked,was
R3779 T14337 T14336 prep to,linked
R3780 T14338 T14339 det the,expression
R3781 T14123 T14122 amod different,alleles
R3782 T14339 T14337 pobj expression,to
R3783 T14340 T14339 prep of,expression
R3784 T14124 T14125 det a,pattern
R3785 T14125 T14111 dobj pattern,followed
R3786 T14126 T14125 compound threshold,pattern
R3787 T14341 T14340 pobj auto-Abs,of
R3788 T14127 T14125 compound liability,pattern
R3789 T14342 T14324 punct .,demonstrated
R3790 T14128 T14129 prep in,depended
R3791 T14344 T14345 det This,region
R3792 T14345 T14346 nsubj region,is
R3793 T14447 T14414 prep to,mapped
R3794 T14346 T14347 ccomp is,occur
R3795 T14348 T14346 advmod probably,is
R3796 T14349 T14346 acomp capable,is
R3797 T14448 T14449 det a,portion
R3798 T14350 T14349 prep of,capable
R3799 T14351 T14350 pcomp causing,of
R3800 T14352 T14353 det the,initiation
R3801 T14449 T14447 pobj portion,to
R3802 T14353 T14351 dobj initiation,causing
R3803 T14354 T14353 prep of,initiation
R3804 T14450 T14449 prep of,portion
R3805 T14355 T14356 det a,response
R3806 T14356 T14354 pobj response,of
R3807 T14357 T14356 amod humoral,response
R3808 T14451 T14450 pobj Chromosome,of
R3809 T14358 T14356 amod autoimmune,response
R3810 T14359 T14356 prep to,response
R3811 T14360 T14361 amod nuclear,antigens
R3812 T14361 T14359 pobj antigens,to
R3813 T14362 T14347 punct ;,occur
R3814 T14363 T14347 advmod however,occur
R3815 T14452 T14451 nummod 3,Chromosome
R3816 T14364 T14347 punct ", ",occur
R3817 T14365 T14366 det this,response
R3818 T14366 T14347 nsubj response,occur
R3819 T14453 T14449 amod close,portion
R3820 T14367 T14347 aux does,occur
R3821 T14368 T14347 neg not,occur
R3822 T14369 T14347 prep in,occur
R3823 T14454 T14453 prep to,close
R3824 T14370 T14371 det the,absence
R3825 T14371 T14369 pobj absence,in
R3826 T14372 T14371 prep of,absence
R3827 T14455 T14456 det the,region
R3828 T14373 T14374 nmod C57BL,genes
R3829 T14374 T14372 pobj genes,of
R3830 T14456 T14454 pobj region,to
R3831 T14375 T14373 punct /,C57BL
R3832 T14376 T14373 nummod 6,C57BL
R3833 T14377 T14347 punct .,occur
R3834 T14457 T14456 acl identified,region
R3835 T14379 T14380 prep In,identified
R3836 T14458 T14457 prep in,identified
R3837 T14381 T14379 pobj support,In
R3838 T14382 T14381 prep of,support
R3839 T14459 T14460 det this,study
R3840 T14383 T14382 pobj this,of
R3841 T14384 T14380 punct ", ",identified
R3842 T14385 T14380 nsubj we,identified
R3843 T14460 T14458 pobj study,in
R3844 T14386 T14387 det a,segment
R3845 T14387 T14380 dobj segment,identified
R3846 T14388 T14387 nmod C57BL,segment
R3847 T14461 T14462 punct (,Morel
R3848 T14389 T14388 punct /,C57BL
R3849 T14390 T14388 nummod 6,C57BL
R3850 T14462 T14414 meta Morel,mapped
R3851 T14391 T14387 prep on,segment
R3852 T14463 T14462 nmod et,Morel
R3853 T14392 T14391 pobj Chromosome,on
R3854 T14393 T14392 nummod 3,Chromosome
R3855 T14464 T14462 nmod al.,Morel
R3856 T14394 T14387 punct ", ",segment
R3857 T14395 T14396 dep which,interact
R3858 T14396 T14387 relcl interact,segment
R3859 T14465 T14462 nummod 1999,Morel
R3860 T14397 T14396 aux may,interact
R3861 T14398 T14396 prep with,interact
R3862 T14399 T14400 det the,genes
R3863 T14400 T14398 pobj genes,with
R3864 T14401 T14400 nummod 129,genes
R3865 T14402 T14400 prep on,genes
R3866 T14466 T14462 punct ;,Morel
R3867 T14403 T14402 pobj Chromosome,on
R3868 T14404 T14403 nummod 1,Chromosome
R3869 T14467 T14462 nmod Haywood,Morel
R3870 T14405 T14406 aux to,mediate
R3871 T14406 T14396 advcl mediate,interact
R3872 T14407 T14408 det the,loss
R3873 T14468 T14462 nmod et,Morel
R3874 T14408 T14406 dobj loss,mediate
R3875 T14409 T14408 prep of,loss
R3876 T14410 T14409 pobj tolerance,of
R3877 T14469 T14462 nmod al.,Morel
R3878 T14411 T14380 punct .,identified
R3879 T14470 T14462 nummod 2000,Morel
R3880 T14413 T14414 advmod Interestingly,mapped
R3881 T14415 T14414 punct ", ",mapped
R3882 T14471 T14462 punct ),Morel
R3883 T14416 T14417 mark although,is
R3884 T14417 T14414 advcl is,mapped
R3885 T14472 T14414 punct .,mapped
R3886 T14418 T14419 det the,region
R3887 T14419 T14417 nsubj region,is
R3888 T14420 T14419 nmod C57BL,region
R3889 T14474 T14475 advmod Furthermore,linked
R3890 T14421 T14420 punct /,C57BL
R3891 T14422 T14420 nummod 6,C57BL
R3892 T14423 T14424 compound SLE,susceptibility
R3893 T14424 T14419 compound susceptibility,region
R3894 T14476 T14475 punct ", ",linked
R3895 T14425 T14424 punct -,susceptibility
R3896 T14426 T14419 prep on,region
R3897 T14427 T14426 pobj Chromosome,on
R3898 T14428 T14427 nummod 3,Chromosome
R3899 T14429 T14417 acomp novel,is
R3900 T14477 T14478 det the,region
R3901 T14430 T14414 punct ", ",mapped
R3902 T14431 T14432 npadvmod disease,modifying
R3903 T14478 T14475 nsubjpass region,linked
R3904 T14432 T14434 amod modifying,alleles
R3905 T14433 T14432 punct -,modifying
R3906 T14434 T14414 nsubjpass alleles,mapped
R3907 T14435 T14434 acl derived,alleles
R3908 T14479 T14478 prep on,region
R3909 T14436 T14435 prep from,derived
R3910 T14437 T14438 nmod C57BL,strains
R3911 T14438 T14436 pobj strains,from
R3912 T14480 T14479 pobj Chromosome,on
R3913 T14439 T14437 punct /,C57BL
R3914 T14440 T14437 nummod 10,C57BL
R3915 T14441 T14437 cc and,C57BL
R3916 T14442 T14437 conj C57BL,C57BL
R3917 T14443 T14442 punct /,C57BL
R3918 T14444 T14442 nummod 6,C57BL
R3919 T14481 T14480 nummod 7,Chromosome
R3920 T14445 T14414 aux have,mapped
R3921 T14446 T14414 auxpass been,mapped
R3922 T14482 T14478 acl associated,region
R3923 T14483 T14482 prep with,associated
R3924 T14484 T14485 det the,development
R3925 T14485 T14483 pobj development,with
R3926 T14553 T14554 advmod as,as
R3927 T14554 T14552 cc as,enhancing
R3928 T14486 T14485 prep of,development
R3929 T14555 T14554 advmod well,as
R3930 T14556 T14552 conj inhibitory,enhancing
R3931 T14557 T14551 prep from,loci
R3932 T14487 T14488 compound lupus,nephritis
R3933 T14558 T14559 det the,mouse
R3934 T14488 T14486 pobj nephritis,of
R3935 T14559 T14557 pobj mouse,from
R3936 T14489 T14475 aux has,linked
R3937 T14560 T14559 nummod 129,mouse
R3938 T14561 T14538 punct ", ",genome
R3939 T14562 T14538 prep in,genome
R3940 T14490 T14475 auxpass been,linked
R3941 T14563 T14562 pobj addition,in
R3942 T14564 T14563 prep to,addition
R3943 T14491 T14475 prep to,linked
R3944 T14565 T14564 pobj genes,to
R3945 T14566 T14565 acl promoting,genes
R3946 T14567 T14566 dobj autoimmunity,promoting
R3947 T14492 T14493 det the,trait
R3948 T14568 T14566 prep from,promoting
R3949 T14569 T14570 det the,mice
R3950 T14493 T14491 pobj trait,to
R3951 T14570 T14568 pobj mice,from
R3952 T14571 T14570 nmod C57BL,mice
R3953 T14572 T14571 punct /,C57BL
R3954 T14494 T14493 amod same,trait
R3955 T14573 T14571 nummod 6,C57BL
R3956 T14574 T14528 punct .,suggest
R3957 T14495 T14475 prep in,linked
R3958 T14576 T14577 det The,impact
R3959 T14577 T14578 nsubjpass impact,assessed
R3960 T14496 T14497 amod other,models
R3961 T14579 T14580 dep that,have
R3962 T14580 T14577 relcl have,impact
R3963 T14497 T14495 pobj models,in
R3964 T14581 T14582 det these,loci
R3965 T14582 T14580 nsubj loci,have
R3966 T14583 T14582 amod interacting,loci
R3967 T14584 T14580 aux may,have
R3968 T14585 T14577 prep on,impact
R3969 T14586 T14587 det the,disease
R3970 T14498 T14497 amod murine,models
R3971 T14587 T14585 pobj disease,on
R3972 T14588 T14589 npadvmod lupus,like
R3973 T14589 T14587 amod like,disease
R3974 T14499 T14497 prep of,models
R3975 T14590 T14589 punct -,like
R3976 T14591 T14587 amod present,disease
R3977 T14592 T14591 prep in,present
R3978 T14500 T14499 pobj SLE,of
R3979 T14593 T14594 amod several,animals
R3980 T14594 T14592 pobj animals,in
R3981 T14501 T14502 punct (,Santiago
R3982 T14595 T14596 npadvmod gene,targeted
R3983 T14596 T14594 amod targeted,animals
R3984 T14597 T14596 punct -,targeted
R3985 T14502 T14475 meta Santiago,linked
R3986 T14598 T14578 auxpass was,assessed
R3987 T14599 T14578 advmod further,assessed
R3988 T14600 T14578 prep by,assessed
R3989 T14503 T14502 nmod et,Santiago
R3990 T14601 T14600 pcomp comparing,by
R3991 T14602 T14603 nmod Apcs,mice
R3992 T14603 T14601 dobj mice,comparing
R3993 T14504 T14502 nmod al.,Santiago
R3994 T14604 T14602 punct −,Apcs
R3995 T14605 T14602 punct /,Apcs
R3996 T14505 T14502 nummod 1998,Santiago
R3997 T14606 T14602 punct −,Apcs
R3998 T14607 T14601 prep with,comparing
R3999 T14608 T14609 npadvmod Chromosome,matched
R4000 T14506 T14502 punct ;,Santiago
R4001 T14609 T14612 amod matched,controls
R4002 T14610 T14608 nummod 1,Chromosome
R4003 T14611 T14609 advmod genetically,matched
R4004 T14507 T14502 nmod Morel,Santiago
R4005 T14612 T14607 pobj controls,with
R4006 T14613 T14578 punct .,assessed
R4007 T14508 T14502 nmod et,Santiago
R4008 T14615 T14616 prep In,is
R4009 T14509 T14502 nmod al.,Santiago
R4010 T14617 T14618 det the,context
R4011 T14618 T14615 pobj context,In
R4012 T14619 T14618 prep of,context
R4013 T14510 T14502 nummod 1999,Santiago
R4014 T14620 T14621 compound SLE,susceptibility
R4015 T14621 T14619 pobj susceptibility,of
R4016 T14511 T14502 punct ;,Santiago
R4017 T14622 T14616 punct ", ",is
R4018 T14623 T14616 nsubj one,is
R4019 T14624 T14623 prep of,one
R4020 T14625 T14626 det the,regions
R4021 T14626 T14624 pobj regions,of
R4022 T14627 T14628 advmod most,consistently
R4023 T14512 T14502 nmod Xie,Santiago
R4024 T14628 T14629 advmod consistently,mapped
R4025 T14629 T14626 amod mapped,regions
R4026 T14630 T14626 amod non-MHC,regions
R4027 T14513 T14502 nmod et,Santiago
R4028 T14631 T14626 prep of,regions
R4029 T14632 T14633 det the,genome
R4030 T14514 T14502 nmod al.,Santiago
R4031 T14633 T14631 pobj genome,of
R4032 T14634 T14633 compound mouse,genome
R4033 T14635 T14636 det the,segment
R4034 T14515 T14502 nummod 2002,Santiago
R4035 T14636 T14616 attr segment,is
R4036 T14637 T14636 amod telomeric,segment
R4037 T14516 T14502 punct ),Santiago
R4038 T14638 T14636 nmod Chromosome,segment
R4039 T14639 T14638 nummod 1,Chromosome
R4040 T14640 T14636 punct ", ",segment
R4041 T14517 T14475 punct ", ",linked
R4042 T14641 T14642 advmod where,mapped
R4043 T14518 T14475 advcl suggesting,linked
R4044 T14642 T14636 relcl mapped,segment
R4045 T14519 T14520 det the,possibility
R4046 T14643 T14644 amod several,loci
R4047 T14644 T14642 nsubjpass loci,mapped
R4048 T14520 T14518 dobj possibility,suggesting
R4049 T14645 T14644 compound disease,loci
R4050 T14646 T14644 punct ", ",loci
R4051 T14647 T14644 acl designated,loci
R4052 T14521 T14520 prep of,possibility
R4053 T14648 T14647 oprd Sle1,designated
R4054 T14649 T14650 punct (,Morel
R4055 T14650 T14648 meta Morel,Sle1
R4056 T14522 T14523 amod shared,loci
R4057 T14651 T14650 nmod et,Morel
R4058 T14652 T14650 nmod al.,Morel
R4059 T14523 T14521 pobj loci,of
R4060 T14653 T14650 nummod 2001,Morel
R4061 T14654 T14650 punct ),Morel
R4062 T14655 T14648 punct ", ",Sle1
R4063 T14524 T14523 compound susceptibility,loci
R4064 T14656 T14648 conj Nba2,Sle1
R4065 T14657 T14658 punct (,Drake
R4066 T14658 T14656 meta Drake,Nba2
R4067 T14525 T14475 punct .,linked
R4068 T14527 T14528 advcl Taken,suggest
R4069 T14529 T14527 advmod together,Taken
R4070 T14659 T14658 nmod et,Drake
R4071 T14660 T14658 nmod al.,Drake
R4072 T14661 T14658 nummod 1995,Drake
R4073 T14662 T14658 punct ;,Drake
R4074 T14663 T14658 nmod Rozzo,Drake
R4075 T14530 T14531 poss our,results
R4078 T14531 T14528 nsubj results,suggest
R4079 T14666 T14658 nummod 1996,Drake
R4080 T14667 T14658 punct ;,Drake
R4081 T14668 T14658 nmod Vyse,Drake
R4082 T14532 T14533 det a,contribution
R4083 T14669 T14658 nmod et,Drake
R4084 T14670 T14658 nmod al.,Drake
R4085 T14671 T14658 nummod 1997,Drake
R4086 T14533 T14528 dobj contribution,suggest
R4087 T14672 T14658 punct ),Drake
R4088 T14673 T14656 punct ", ",Nba2
R4089 T14534 T14533 amod complex,contribution
R4090 T14674 T14656 cc and,Nba2
R4091 T14675 T14656 conj Bxs3,Nba2
R4092 T14676 T14677 punct (,Hogarth
R4093 T14535 T14533 amod genetic,contribution
R4094 T14677 T14675 meta Hogarth,Bxs3
R4095 T14678 T14677 nmod et,Hogarth
R4096 T14536 T14533 prep from,contribution
R4097 T14679 T14677 nmod al.,Hogarth
R4098 T14680 T14677 nummod 1998,Hogarth
R4099 T14537 T14538 det the,genome
R4100 T14681 T14677 punct ),Hogarth
R4101 T14682 T14642 punct ", ",mapped
R4102 T14683 T14642 aux have,mapped
R4103 T14538 T14536 pobj genome,from
R4104 T14684 T14642 auxpass been,mapped
R4105 T14685 T14642 prep in,mapped
R4106 T14539 T14538 punct (,genome
R4107 T14686 T14687 npadvmod lupus,prone
R4108 T14687 T14689 amod prone,strains
R4109 T14688 T14687 punct -,prone
R4110 T14540 T14538 nummod 129,genome
R4111 T14689 T14685 pobj strains,in
R4112 T14690 T14616 punct .,is
R4113 T14541 T14540 punct ×,129
R4114 T14692 T14693 advmod Moreover,is
R4115 T14542 T14540 appos C57BL,129
R4116 T14694 T14693 punct ", ",is
R4117 T14695 T14696 det this,region
R4118 T14696 T14693 nsubj region,is
R4119 T14543 T14542 punct /,C57BL
R4120 T14697 T14696 prep of,region
R4121 T14698 T14699 compound mouse,Chromosome
R4122 T14699 T14697 pobj Chromosome,of
R4123 T14700 T14699 nummod 1,Chromosome
R4124 T14701 T14693 acomp orthologous,is
R4125 T14702 T14701 prep to,orthologous
R4126 T14544 T14542 nummod 6,C57BL
R4127 T14703 T14704 det a,region
R4128 T14704 T14702 pobj region,to
R4129 T14705 T14704 prep on,region
R4130 T14545 T14538 punct ),genome
R4131 T14706 T14707 amod human,1q22
R4132 T14546 T14538 amod hybrid,genome
R4133 T14707 T14705 pobj 1q22,on
R4134 T14547 T14538 compound background,genome
R4135 T14708 T14707 compound Chromosome,1q22
R4136 T14709 T14710 punct –,1q25
R4137 T14710 T14707 prep 1q25,1q22
R4138 T14548 T14538 punct ", ",genome
R4139 T14711 T14704 punct ", ",region
R4140 T14712 T14713 dep which,linked
R4141 T14549 T14538 prep with,genome
R4142 T14713 T14704 relcl linked,region
R4143 T14714 T14713 aux has,linked
R4144 T14715 T14713 advmod also,linked
R4145 T14550 T14551 det both,loci
R4146 T14716 T14713 auxpass been,linked
R4147 T14717 T14713 prep with,linked
R4148 T14718 T14719 amod human,SLE
R4149 T14551 T14549 pobj loci,with
R4150 T14719 T14717 pobj SLE,with
R4151 T14720 T14721 punct (,Moser
R4152 T14552 T14551 amod enhancing,loci
R4153 T14721 T14713 meta Moser,linked
R4154 T14722 T14721 nmod et,Moser
R4155 T14723 T14721 nmod al.,Moser
R4156 T14765 T14754 advmod vitro,DNA
R4157 T14724 T14721 nummod 1998,Moser
R4158 T14725 T14721 punct ),Moser
R4159 T14726 T14693 punct .,is
R4160 T14766 T14767 punct (,Pepys
R4161 T14767 T14754 meta Pepys,DNA
R4162 T14728 T14729 det The,gene
R4163 T14729 T14731 nsubj gene,is
R4164 T14768 T14767 nummod 1974,Pepys
R4165 T14730 T14729 compound Apcs,gene
R4166 T14769 T14767 punct ;,Pepys
R4167 T14732 T14731 attr one,is
R4168 T14733 T14732 prep of,one
R4169 T14734 T14735 det the,genes
R4170 T14770 T14767 conj Pepys,Pepys
R4171 T14735 T14733 pobj genes,of
R4172 T14736 T14735 compound candidate,genes
R4173 T14771 T14770 cc and,Pepys
R4174 T14737 T14735 acl known,genes
R4175 T14738 T14739 aux to,lie
R4176 T14739 T14737 xcomp lie,known
R4177 T14740 T14739 prep within,lie
R4178 T14741 T14742 det this,region
R4180 T14742 T14740 pobj region,within
R4181 T14743 T14731 punct .,is
R4182 T14773 T14772 nummod 1987,Butler
R4183 T14745 T14746 det The,component
R4184 T14746 T14751 nsubj component,binds
R4185 T14774 T14772 punct ;,Butler
R4186 T14747 T14746 amod human,component
R4187 T14748 T14749 compound serum,P
R4188 T14775 T14772 conj Butler,Butler
R4189 T14749 T14746 compound P,component
R4190 T14750 T14749 compound amyloid,P
R4191 T14776 T14775 nmod et,Butler
R4192 T14752 T14751 advmod avidly,binds
R4193 T14753 T14751 prep to,binds
R4194 T14777 T14775 nmod al.,Butler
R4195 T14754 T14753 pobj DNA,to
R4196 T14755 T14754 punct ", ",DNA
R4197 T14756 T14754 conj chromatin,DNA
R4198 T14778 T14775 nummod 1990,Butler
R4199 T14757 T14756 punct ", ",chromatin
R4200 T14758 T14756 cc and,chromatin
R4201 T14779 T14775 punct ),Butler
R4202 T14759 T14760 amod apoptotic,cells
R4203 T14760 T14756 conj cells,chromatin
R4204 T14761 T14754 prep in,DNA
R4205 T14780 T14753 cc and,to
R4206 T14762 T14763 amod physiological,conditions
R4207 T14763 T14761 pobj conditions,in
R4208 T14764 T14765 advmod in,vitro
R4209 T14781 T14780 advmod also,and
R4210 T14782 T14753 conj to,to
R4211 T14783 T14784 amod exposed,chromatin
R4212 T14784 T14782 pobj chromatin,to
R4213 T14871 T14870 prep of,pathogenesis
R4214 T14785 T14784 cc and,chromatin
R4215 T14872 T14871 pobj SLE,of
R4216 T14873 T14848 punct .,postulated
R4217 T14786 T14787 amod apoptotic,cells
R4218 T14875 T14876 advmod However,found
R4219 T14787 T14784 conj cells,chromatin
R4220 T14877 T14876 punct ", ",found
R4221 T14878 T14876 prep in,found
R4222 T14879 T14880 det this,study
R4223 T14788 T14789 advmod in,vivo
R4224 T14880 T14878 pobj study,in
R4225 T14881 T14876 nsubj we,found
R4226 T14882 T14883 mark that,increased
R4227 T14883 T14876 ccomp increased,found
R4228 T14884 T14885 advmod only,levels
R4229 T14789 T14784 advmod vivo,chromatin
R4230 T14885 T14883 nsubjpass levels,increased
R4231 T14886 T14885 nmod ANA,levels
R4232 T14887 T14886 cc and,ANA
R4233 T14790 T14791 punct (,Hintner
R4234 T14888 T14889 amod anti-chromatin,Ab
R4235 T14889 T14886 conj Ab,ANA
R4236 T14890 T14883 auxpass were,increased
R4237 T14791 T14784 meta Hintner,chromatin
R4238 T14891 T14883 advmod significantly,increased
R4239 T14892 T14883 prep in,increased
R4240 T14893 T14894 det the,mice
R4241 T14792 T14791 nmod et,Hintner
R4242 T14793 T14791 nmod al.,Hintner
R4243 T14894 T14892 pobj mice,in
R4244 T14895 T14894 punct (,mice
R4245 T14794 T14791 nummod 1988,Hintner
R4246 T14896 T14897 nummod 129,F2
R4247 T14897 T14894 nmod F2,mice
R4248 T14898 T14896 punct ×,129
R4249 T14795 T14791 punct ;,Hintner
R4250 T14899 T14896 appos C57BL,129
R4251 T14900 T14899 punct /,C57BL
R4252 T14901 T14899 nummod 6,C57BL
R4253 T14796 T14791 nmod Breathnach,Hintner
R4254 T14902 T14897 punct ),F2
R4255 T14903 T14897 punct .,F2
R4256 T14904 T14897 appos Apcs,F2
R4257 T14797 T14791 nmod et,Hintner
R4258 T14905 T14904 punct −,Apcs
R4259 T14906 T14904 punct /,Apcs
R4260 T14798 T14791 nmod al.,Hintner
R4261 T14907 T14904 punct −,Apcs
R4262 T14908 T14876 punct .,found
R4263 T14799 T14791 nummod 1989,Hintner
R4264 T14910 T14911 det A,explanation
R4265 T14800 T14791 punct ;,Hintner
R4266 T14911 T14913 nsubj explanation,lie
R4267 T14912 T14911 amod possible,explanation
R4268 T14801 T14791 nmod Familian,Hintner
R4269 T14914 T14911 prep for,explanation
R4270 T14915 T14916 det this,discrepancy
R4271 T14802 T14791 nmod et,Hintner
R4272 T14916 T14914 pobj discrepancy,for
R4273 T14917 T14913 aux may,lie
R4274 T14803 T14791 nmod al.,Hintner
R4275 T14918 T14913 prep in,lie
R4276 T14919 T14920 det the,fact
R4277 T14920 T14918 pobj fact,in
R4278 T14921 T14922 mark that,generated
R4279 T14922 T14920 advcl generated,fact
R4280 T14923 T14924 det the,mice
R4281 T14804 T14791 nummod 2001,Hintner
R4282 T14924 T14922 nsubjpass mice,generated
R4283 T14925 T14924 nmod Apcs,mice
R4284 T14926 T14925 punct −,Apcs
R4285 T14805 T14791 punct ),Hintner
R4286 T14927 T14925 punct /,Apcs
R4287 T14928 T14925 punct −,Apcs
R4288 T14929 T14924 acl analysed,mice
R4289 T14806 T14751 punct .,binds
R4290 T14930 T14929 prep in,analysed
R4291 T14931 T14932 det the,study
R4292 T14808 T14809 nsubj We,reported
R4293 T14932 T14930 pobj study,in
R4294 T14933 T14932 amod original,study
R4295 T14934 T14922 auxpass were,generated
R4296 T14935 T14922 prep from,generated
R4297 T14810 T14809 aux have,reported
R4298 T14936 T14937 det a,number
R4299 T14937 T14935 pobj number,from
R4300 T14938 T14937 amod limited,number
R4301 T14939 T14937 prep of,number
R4302 T14811 T14809 advmod previously,reported
R4303 T14940 T14939 pobj founders,of
R4304 T14941 T14922 cc and,generated
R4305 T14942 T14943 mark that,caused
R4306 T14812 T14813 mark that,produce
R4307 T14943 T14922 conj caused,generated
R4308 T14944 T14943 nsubj this,caused
R4309 T14813 T14809 ccomp produce,reported
R4310 T14945 T14943 aux may,caused
R4311 T14946 T14943 aux have,caused
R4312 T14947 T14948 det a,inheritance
R4313 T14814 T14813 punct (,produce
R4314 T14948 T14943 dobj inheritance,caused
R4315 T14949 T14948 amod nonrandom,inheritance
R4316 T14815 T14816 nummod 129,mice
R4317 T14950 T14948 prep of,inheritance
R4318 T14951 T14952 det the,loci
R4319 T14952 T14950 pobj loci,of
R4320 T14816 T14813 nsubj mice,produce
R4321 T14953 T14948 prep from,inheritance
R4322 T14954 T14955 det the,strains
R4323 T14955 T14953 pobj strains,from
R4324 T14817 T14815 punct ×,129
R4325 T14956 T14955 amod parental,strains
R4326 T14957 T14913 punct .,lie
R4327 T14818 T14815 appos C57BL,129
R4328 T14959 T14960 advmod Furthermore,identified
R4329 T14819 T14818 punct /,C57BL
R4330 T14961 T14960 punct ", ",identified
R4331 T14962 T14963 det the,analysis
R4332 T14963 T14960 nsubj analysis,identified
R4333 T14964 T14965 amod whole,genome
R4334 T14965 T14963 compound genome,analysis
R4335 T14820 T14818 nummod 6,C57BL
R4336 T14966 T14965 punct -,genome
R4337 T14967 T14968 det the,region
R4338 T14968 T14960 dobj region,identified
R4339 T14821 T14815 punct ),129
R4340 T14969 T14968 nummod 129,region
R4341 T14970 T14968 acl surrounding,region
R4342 T14971 T14972 det the,gene
R4343 T14972 T14970 dobj gene,surrounding
R4344 T14822 T14815 punct .,129
R4345 T14973 T14972 compound Apcs,gene
R4346 T14974 T14960 prep as,identified
R4347 T14975 T14976 det the,locus
R4348 T14823 T14815 appos Apcs,129
R4349 T14976 T14974 pobj locus,as
R4350 T14824 T14823 punct −,Apcs
R4351 T14825 T14823 punct /,Apcs
R4352 T14977 T14976 amod main,locus
R4353 T14826 T14823 punct −,Apcs
R4354 T14978 T14976 acl contributing,locus
R4355 T14979 T14978 prep to,contributing
R4356 T14827 T14813 advmod spontaneously,produce
R4357 T14980 T14981 det the,development
R4358 T14981 T14979 pobj development,to
R4359 T14828 T14829 det a,range
R4360 T14982 T14981 prep of,development
R4361 T14983 T14982 pobj ANA,of
R4362 T14829 T14813 dobj range,produce
R4363 T14984 T14983 cc and,ANA
R4364 T14830 T14829 amod wide,range
R4365 T14985 T14986 amod anti-chromatin,Ab
R4366 T14986 T14983 conj Ab,ANA
R4367 T14831 T14829 prep of,range
R4368 T14987 T14960 punct .,identified
R4369 T14989 T14990 prep In,failed
R4370 T14832 T14831 pobj ANAs,of
R4371 T14991 T14989 pobj agreement,In
R4372 T14833 T14813 cc and,produce
R4373 T14992 T14991 prep with,agreement
R4374 T14993 T14992 pobj this,with
R4375 T14994 T14990 punct ", ",failed
R4376 T14834 T14813 conj develop,produce
R4377 T14995 T14996 advmod when,carried
R4378 T14996 T14990 advcl carried,failed
R4379 T14835 T14836 amod significant,glomerulonephritis
R4380 T14997 T14996 nsubj we,carried
R4381 T14998 T14996 prt out,carried
R4382 T14999 T15000 det a,comparison
R4383 T15000 T14996 dobj comparison,carried
R4384 T15001 T15000 amod selective,comparison
R4385 T15002 T15000 prep between,comparison
R4386 T14836 T14834 dobj glomerulonephritis,develop
R4387 T15003 T15004 det the,mice
R4388 T15004 T15002 pobj mice,between
R4389 T15005 T15004 punct (,mice
R4390 T14837 T14838 amod immune,complex
R4391 T15006 T15007 nummod 129,F2
R4392 T15007 T15004 nmod F2,mice
R4393 T15008 T15006 punct ×,129
R4394 T14838 T14836 compound complex,glomerulonephritis
R4395 T15009 T15006 appos C57BL,129
R4396 T15010 T15009 punct /,C57BL
R4397 T15011 T15009 nummod 6,C57BL
R4398 T14839 T14840 punct (,Bickerstaff
R4399 T15012 T15007 punct ),F2
R4400 T15013 T15007 punct .,F2
R4401 T15014 T15007 appos Apcs,F2
R4402 T14840 T14834 meta Bickerstaff,develop
R4403 T15015 T15014 punct −,Apcs
R4404 T15016 T15014 punct /,Apcs
R4405 T14841 T14840 nmod et,Bickerstaff
R4406 T15017 T15014 punct −,Apcs
R4407 T15018 T15004 cc and,mice
R4408 T15019 T15020 nmod Chromosome,controls
R4409 T14842 T14840 nmod al.,Bickerstaff
R4410 T15020 T15004 conj controls,mice
R4411 T15021 T15019 nummod 1,Chromosome
R4412 T14843 T14840 nummod 1999,Bickerstaff
R4413 T15022 T15023 advmod genetically,matched
R4414 T15023 T15020 amod matched,controls
R4415 T15024 T14990 punct ", ",failed
R4416 T14844 T14840 punct ),Bickerstaff
R4417 T15025 T14990 nsubj we,failed
R4418 T15026 T15027 aux to,detect
R4419 T15027 T14990 xcomp detect,failed
R4420 T14845 T14809 punct .,reported
R4421 T15028 T15029 det any,difference
R4422 T15029 T15027 dobj difference,detect
R4423 T15030 T15029 amod significant,difference
R4424 T14847 T14848 prep On,postulated
R4425 T15031 T15029 prep in,difference
R4426 T15032 T15033 det the,levels
R4427 T15033 T15031 pobj levels,in
R4428 T15034 T15033 prep of,levels
R4429 T14849 T14850 det the,basis
R4431 T15036 T15034 pobj auto-Abs,of
R4432 T15037 T15036 nummod two,auto-Abs
R4436 T14850 T14847 pobj basis,On
R4437 T15043 T15042 punct ", ",indicated
R4438 T15044 T15042 advcl taken,indicated
R4439 T15045 T15044 advmod together,taken
R4440 T14851 T14850 prep of,basis
R4441 T15046 T15042 punct ", ",indicated
R4442 T15047 T15048 mark that,caused
R4443 T15048 T15042 ccomp caused,indicated
R4444 T14852 T14853 det these,observations
R4445 T15049 T15050 det the,phenotype
R4446 T15050 T15048 nsubjpass phenotype,caused
R4447 T15051 T15050 acl associated,phenotype
R4448 T14853 T14851 pobj observations,of
R4449 T15052 T15051 prep with,associated
R4450 T15053 T15054 compound Apcs,deficiency
R4451 T15054 T15052 pobj deficiency,with
R4452 T14854 T14848 punct ", ",postulated
R4453 T15055 T15048 auxpass was,caused
R4454 T15056 T15048 agent by,caused
R4455 T15057 T15058 det the,presence
R4456 T14855 T14848 nsubjpass it,postulated
R4457 T15058 T15056 pobj presence,by
R4458 T15059 T15058 prep of,presence
R4459 T14856 T14848 auxpass was,postulated
R4460 T15060 T15061 amod unaltered,genes
R4461 T15061 T15059 pobj genes,of
R4462 T15062 T15061 nummod 129,genes
R4463 T14857 T14858 mark that,contributes
R4464 T15063 T15061 prep from,genes
R4465 T15064 T15065 det the,region
R4466 T15065 T15063 pobj region,from
R4467 T14858 T14848 ccomp contributes,postulated
R4468 T15066 T15065 amod telomeric,region
R4469 T15067 T15065 prep of,region
R4470 T15068 T15067 pobj Chromosome,of
R4471 T14859 T14858 nsubj Apcs,contributes
R4472 T15069 T15068 nummod 1,Chromosome
R4473 T14860 T14858 punct ", ",contributes
R4474 T15070 T15061 acl operating,genes
R4475 T15071 T15070 prep in,operating
R4476 T14861 T14858 prep by,contributes
R4477 T15072 T15073 det the,background
R4478 T15073 T15071 pobj background,in
R4479 T15074 T15073 nmod C57BL,background
R4480 T14862 T14861 pcomp altering,by
R4481 T15075 T15074 punct /,C57BL
R4482 T15076 T15074 nummod 6,C57BL
R4483 T15077 T15073 amod genomic,background
R4484 T14863 T14864 det the,clearance
R4485 T15078 T15042 punct .,indicated
R4486 T15080 T15081 amod Strong,evidence
R4487 T15081 T15083 nsubjpass evidence,provided
R4488 T15082 T15081 amod supportive,evidence
R4489 T14864 T14862 dobj clearance,altering
R4490 T14865 T14864 prep of,clearance
R4491 T14866 T14865 pobj chromatin,of
R4492 T14867 T14858 punct ", ",contributes
R4493 T14868 T14858 prep to,contributes
R4494 T15084 T15081 prep for,evidence
R4495 T15085 T15084 pobj this,for
R4496 T15086 T15083 auxpass was,provided
R4497 T14869 T14870 det the,pathogenesis
R4498 T15087 T15083 agent by,provided
R4499 T15088 T15089 det the,analysis
R4500 T15089 T15087 pobj analysis,by
R4501 T14870 T14868 pobj pathogenesis,to
R4502 T15090 T15089 prep of,analysis
R4503 T15091 T15092 det the,mice
R4504 T15189 T15188 pobj C57BL,onto
R4505 T15092 T15090 pobj mice,of
R4506 T15190 T15189 punct /,C57BL
R4507 T15093 T15092 nmod C57BL,mice
R4508 T15191 T15189 nummod 6,C57BL
R4509 T15094 T15093 punct /,C57BL
R4510 T15095 T15093 nummod 6,C57BL
R4511 T15096 T15089 amod congenic,analysis
R4512 T15192 T15193 det a,gene
R4513 T15097 T15096 prep for,congenic
R4514 T15098 T15099 det this,region
R4515 T15099 T15097 pobj region,for
R4516 T15193 T15187 dobj gene,backcrossing
R4517 T15100 T15099 nummod 129,region
R4518 T15101 T15083 punct .,provided
R4519 T15194 T15193 amod mutated,gene
R4520 T15103 T15104 det The,generation
R4521 T15104 T15105 nsubjpass generation,used
R4522 T15195 T15193 acl located,gene
R4523 T15106 T15104 cc and,generation
R4524 T15107 T15104 conj analysis,generation
R4525 T15196 T15195 prep in,located
R4526 T15108 T15104 prep of,generation
R4527 T15109 T15110 amod congenic,strains
R4528 T15197 T15198 det that,region
R4529 T15110 T15108 pobj strains,of
R4530 T15111 T15105 aux have,used
R4531 T15112 T15105 advmod successfully,used
R4532 T15113 T15105 auxpass been,used
R4533 T15198 T15196 pobj region,in
R4534 T15114 T15115 aux to,dissect
R4535 T15115 T15105 advcl dissect,used
R4536 T15199 T15198 amod chromosomal,region
R4537 T15116 T15117 det the,contribution
R4538 T15117 T15115 dobj contribution,dissect
R4539 T15118 T15117 prep of,contribution
R4540 T15119 T15120 amod individual,alleles
R4541 T15120 T15118 pobj alleles,of
R4542 T15200 T15164 punct ", ",was
R4543 T15121 T15120 compound susceptibility,alleles
R4544 T15122 T15117 prep to,contribution
R4545 T15123 T15124 det a,trait
R4546 T15201 T15164 acomp sufficient,was
R4547 T15124 T15122 pobj trait,to
R4548 T15125 T15124 amod multigenic,trait
R4549 T15126 T15127 amod such,as
R4550 T15202 T15203 aux to,mediate
R4551 T15127 T15124 prep as,trait
R4552 T15128 T15127 pobj SLE,as
R4553 T15129 T15105 punct .,used
R4554 T15203 T15201 xcomp mediate,sufficient
R4555 T15131 T15132 nsubj We,adopted
R4556 T15204 T15205 det the,production
R4557 T15133 T15134 det the,strategy
R4558 T15134 T15132 dobj strategy,adopted
R4559 T15205 T15203 dobj production,mediate
R4560 T15135 T15134 amod same,strategy
R4561 T15136 T15137 aux to,investigate
R4562 T15137 T15132 advcl investigate,adopted
R4563 T15206 T15205 prep of,production
R4564 T15138 T15139 det the,contribution
R4565 T15139 T15137 dobj contribution,investigate
R4566 T15140 T15139 amod relative,contribution
R4567 T15207 T15206 pobj auto-Abs,of
R4568 T15141 T15139 prep of,contribution
R4569 T15142 T15143 det the,segment
R4570 T15143 T15141 pobj segment,of
R4571 T15208 T15158 punct .,demonstrated
R4572 T15144 T15143 nummod 129,segment
R4573 T15145 T15143 nmod Chromosome,segment
R4574 T15210 T15211 prep In,is
R4575 T15146 T15145 nummod 1,Chromosome
R4576 T15147 T15143 cc and,segment
R4577 T15148 T15149 det the,gene
R4578 T15149 T15143 conj gene,segment
R4579 T15212 T15213 det this,context
R4580 T15150 T15149 compound Apcs,gene
R4581 T15151 T15139 prep to,contribution
R4582 T15152 T15153 det each,trait
R4583 T15153 T15151 pobj trait,to
R4584 T15213 T15210 pobj context,In
R4585 T15154 T15153 compound disease,trait
R4586 T15155 T15132 punct .,adopted
R4587 T15214 T15211 punct ", ",is
R4588 T15157 T15158 advcl Using,demonstrated
R4589 T15215 T15211 nsubj it,is
R4590 T15159 T15160 det this,approach
R4591 T15160 T15157 dobj approach,Using
R4592 T15161 T15158 punct ", ",demonstrated
R4593 T15162 T15158 nsubj we,demonstrated
R4594 T15216 T15211 prep of,is
R4595 T15163 T15164 mark that,was
R4596 T15164 T15158 ccomp was,demonstrated
R4597 T15217 T15216 pobj note,of
R4598 T15165 T15166 det the,interval
R4599 T15166 T15164 nsubj interval,was
R4600 T15167 T15166 nummod 129,interval
R4602 T15168 T15166 prep on,interval
R4603 T15169 T15170 amod distal,Chromosome
R4604 T15219 T15211 ccomp reported,is
R4605 T15170 T15168 pobj Chromosome,on
R4606 T15171 T15170 nummod 1,Chromosome
R4607 T15172 T15164 punct ", ",was
R4608 T15220 T15221 amod several,strains
R4609 T15173 T15174 advmod when,transferred
R4610 T15174 T15164 advcl transferred,was
R4611 T15175 T15174 prep onto,transferred
R4612 T15221 T15219 nsubjpass strains,reported
R4613 T15176 T15177 det the,genome
R4614 T15177 T15175 pobj genome,onto
R4615 T15178 T15177 nmod C57BL,genome
R4616 T15222 T15221 prep of,strains
R4617 T15179 T15178 punct /,C57BL
R4618 T15180 T15178 nummod 6,C57BL
R4619 T15181 T15177 punct ", ",genome
R4620 T15223 T15222 pobj mice,of
R4621 T15182 T15183 det a,combination
R4622 T15183 T15177 appos combination,genome
R4623 T15224 T15223 prep with,mice
R4624 T15184 T15185 advmod commonly,created
R4625 T15185 T15183 acl created,combination
R4626 T15186 T15185 prep by,created
R4627 T15225 T15226 amod targeted,mutations
R4628 T15187 T15186 pcomp backcrossing,by
R4629 T15188 T15187 prep onto,backcrossing
R4630 T15226 T15224 pobj mutations,with
R4631 T15227 T15226 prep of,mutations
R4632 T15228 T15227 pobj genes,of
R4633 T15229 T15228 acl encoded,genes
R4634 T15294 T15295 det the,phenotype
R4635 T15295 T15290 nsubjpass phenotype,described
R4636 T15230 T15229 prep in,encoded
R4637 T15296 T15295 amod autoimmune,phenotype
R4638 T15297 T15290 auxpass was,described
R4639 T15231 T15232 det this,region
R4640 T15298 T15290 prep in,described
R4641 T15299 T15298 pobj mice,in
R4642 T15300 T15301 prep in,generated
R4643 T15301 T15299 relcl generated,mice
R4644 T15302 T15300 pobj which,in
R4645 T15232 T15230 pobj region,in
R4646 T15303 T15304 det the,mutation
R4647 T15304 T15301 nsubj mutation,generated
R4648 T15305 T15304 amod null,mutation
R4649 T15233 T15219 aux have,reported
R4650 T15306 T15301 aux was,generated
R4651 T15307 T15301 prep in,generated
R4652 T15308 T15309 nummod 129,cells
R4653 T15234 T15219 auxpass been,reported
R4654 T15309 T15307 pobj cells,in
R4655 T15310 T15309 amod embryonic,cells
R4656 T15235 T15236 aux to,express
R4657 T15311 T15309 compound stem,cells
R4658 T15312 T15301 cc and,generated
R4659 T15313 T15314 advmod then,backcrossed
R4660 T15236 T15219 xcomp express,reported
R4661 T15314 T15301 conj backcrossed,generated
R4662 T15315 T15314 prep to,backcrossed
R4663 T15237 T15238 det a,illness
R4664 T15316 T15317 det the,C57BL
R4665 T15317 T15315 pobj C57BL,to
R4666 T15318 T15317 punct /,C57BL
R4667 T15238 T15236 dobj illness,express
R4668 T15319 T15317 nummod 6,C57BL
R4669 T15320 T15317 cc or,C57BL
R4670 T15321 T15322 det another,background
R4671 T15239 T15240 npadvmod lupus,like
R4672 T15322 T15317 conj background,C57BL
R4673 T15323 T15322 amod genetic,background
R4674 T15240 T15238 amod like,illness
R4675 T15324 T15290 punct .,described
R4676 T15241 T15240 punct -,like
R4677 T15326 T15327 advmod Thus,postulate
R4678 T15242 T15219 punct ", ",reported
R4679 T15328 T15327 punct ", ",postulate
R4680 T15329 T15327 prep in,postulate
R4681 T15243 T15219 prep including,reported
R4682 T15330 T15329 pobj view,in
R4683 T15331 T15330 prep of,view
R4684 T15244 T15243 pobj mice,including
R4685 T15332 T15333 poss our,findings
R4686 T15333 T15331 pobj findings,of
R4687 T15334 T15327 punct ", ",postulate
R4688 T15245 T15244 acl lacking,mice
R4689 T15335 T15327 nsubj one,postulate
R4690 T15336 T15327 aux may,postulate
R4691 T15246 T15245 dobj FcγRIIB,lacking
R4692 T15337 T15338 mark that,were
R4693 T15338 T15327 ccomp were,postulate
R4694 T15339 T15338 prep in,were
R4695 T15340 T15339 pobj each,in
R4696 T15341 T15340 prep of,each
R4697 T15342 T15343 det these,models
R4698 T15247 T15248 punct (,Bolland
R4699 T15343 T15341 pobj models,of
R4700 T15344 T15343 amod murine,models
R4701 T15345 T15343 prep of,models
R4702 T15248 T15246 meta Bolland,FcγRIIB
R4703 T15346 T15345 pobj SLE,of
R4704 T15347 T15338 punct ", ",were
R4705 T15348 T15349 det the,effects
R4706 T15249 T15248 cc and,Bolland
R4707 T15349 T15338 nsubj effects,were
R4708 T15350 T15349 prep of,effects
R4709 T15250 T15248 conj Ravetch,Bolland
R4710 T15351 T15352 det the,gene
R4711 T15352 T15350 pobj gene,of
R4712 T15353 T15352 amod targeted,gene
R4713 T15251 T15250 nummod 2000,Ravetch
R4714 T15354 T15352 amod null,gene
R4715 T15355 T15338 acomp irrelevant,were
R4716 T15356 T15327 punct .,postulate
R4717 T15252 T15250 punct ),Ravetch
R4718 T15358 T15359 amod Similar,conclusions
R4719 T15253 T15246 punct ", ",FcγRIIB
R4720 T15359 T15360 nsubj conclusions,apply
R4721 T15361 T15360 aux may,apply
R4722 T15254 T15255 compound complement,receptors
R4723 T15362 T15360 prep to,apply
R4724 T15363 T15364 amod other,animals
R4725 T15255 T15246 conj receptors,FcγRIIB
R4726 T15364 T15362 pobj animals,to
R4727 T15365 T15366 npadvmod gene,targeted
R4728 T15366 T15364 amod targeted,animals
R4729 T15256 T15255 punct (,receptors
R4730 T15367 T15366 punct -,targeted
R4731 T15368 T15364 acl carrying,animals
R4732 T15369 T15368 dobj mutations,carrying
R4733 T15257 T15255 appos CR1,receptors
R4734 T15370 T15369 prep of,mutations
R4735 T15371 T15370 pobj genes,of
R4736 T15258 T15257 punct /,CR1
R4737 T15372 T15371 acl mapped,genes
R4738 T15373 T15372 prep in,mapped
R4739 T15374 T15375 det the,allele
R4740 T15259 T15257 nummod 2,CR1
R4741 T15375 T15373 pobj allele,in
R4742 T15376 T15377 advmod 129,derived
R4743 T15377 T15375 amod derived,allele
R4744 T15260 T15255 punct ),receptors
R4745 T15378 T15377 punct -,derived
R4746 T15379 T15375 compound susceptibility,allele
R4747 T15380 T15372 prep on,mapped
R4748 T15381 T15380 pobj Chromosome,on
R4749 T15382 T15381 nummod 7,Chromosome
R4750 T15261 T15262 punct (,Prodeus
R4751 T15383 T15384 punct (,O'Keefe
R4752 T15384 T15360 meta O'Keefe,apply
R4753 T15385 T15384 nmod et,O'Keefe
R4754 T15262 T15255 meta Prodeus,receptors
R4755 T15386 T15384 nmod al.,O'Keefe
R4756 T15387 T15384 nummod 1996,O'Keefe
R4757 T15388 T15384 punct ", ",O'Keefe
R4758 T15263 T15262 nmod et,Prodeus
R4759 T15389 T15384 nummod 1999,O'Keefe
R4760 T15390 T15384 punct ),O'Keefe
R4761 T15391 T15360 punct .,apply
R4762 T15264 T15262 nmod al.,Prodeus
R4763 T15393 T15394 det The,expression
R4764 T15394 T15395 nsubj expression,was
R4765 T15265 T15262 nummod 1998,Prodeus
R4766 T15396 T15394 prep of,expression
R4767 T15266 T15262 punct ;,Prodeus
R4768 T15397 T15398 amod anti-nuclear,autoimmunity
R4769 T15398 T15396 pobj autoimmunity,of
R4770 T15399 T15395 acomp identical,was
R4771 T15267 T15262 nmod Wu,Prodeus
R4772 T15268 T15262 nmod et,Prodeus
R4773 T15269 T15262 nmod al.,Prodeus
R4774 T15400 T15395 advcl comparing,was
R4775 T15401 T15402 det the,congenic
R4776 T15402 T15400 dative congenic,comparing
R4777 T15270 T15262 nummod 2002,Prodeus
R4781 T15271 T15262 punct ),Prodeus
R4782 T15406 T15405 punct −,Apcs
R4783 T15407 T15405 punct /,Apcs
R4784 T15408 T15405 punct −,Apcs
R4785 T15272 T15255 punct ", ",receptors
R4786 T15409 T15400 dobj mice,comparing
R4787 T15410 T15395 punct .,was
R4788 T15273 T15255 cc and,receptors
R4789 T15412 T15413 det The,difference
R4790 T15274 T15275 npadvmod decay,accelerating
R4791 T15413 T15415 nsubj difference,was
R4792 T15414 T15413 amod only,difference
R4793 T15275 T15277 amod accelerating,factor
R4794 T15416 T15413 prep in,difference
R4795 T15417 T15416 pobj phenotype,in
R4796 T15276 T15275 punct -,accelerating
R4797 T15418 T15413 prep between,difference
R4798 T15419 T15420 det these,mice
R4799 T15420 T15418 pobj mice,between
R4800 T15421 T15415 prep in,was
R4801 T15277 T15255 conj factor,receptors
R4802 T15422 T15423 det the,expression
R4803 T15423 T15421 pobj expression,in
R4804 T15424 T15423 prep of,expression
R4805 T15278 T15277 punct (,factor
R4806 T15425 T15424 pobj glomerulonephritis,of
R4807 T15426 T15423 punct ", ",expression
R4808 T15427 T15428 dep which,was
R4809 T15279 T15277 appos CD55,factor
R4810 T15428 T15423 relcl was,expression
R4811 T15429 T15430 advmod more,pronounced
R4812 T15430 T15428 acomp pronounced,was
R4813 T15280 T15277 punct ),factor
R4814 T15431 T15428 prep in,was
R4815 T15432 T15433 det the,mice
R4816 T15433 T15431 pobj mice,in
R4817 T15281 T15282 punct (,Miwa
R4818 T15434 T15433 nmod Apcs,mice
R4819 T15435 T15434 punct −,Apcs
R4820 T15436 T15434 punct /,Apcs
R4821 T15282 T15277 meta Miwa,factor
R4822 T15437 T15434 punct −,Apcs
R4823 T15438 T15428 prep compared,was
R4824 T15283 T15282 nmod et,Miwa
R4825 T15439 T15438 prep with,compared
R4826 T15440 T15441 det the,mice
R4827 T15441 T15439 pobj mice,with
R4828 T15284 T15282 nmod al.,Miwa
R4829 T15442 T15441 amod congenic,mice
R4830 T15443 T15415 punct .,was
R4831 T15285 T15282 nummod 2002,Miwa
R4832 T15445 T15446 mark Although,demonstrate
R4833 T15446 T15449 advcl demonstrate,indicate
R4834 T15447 T15448 det these,findings
R4835 T15286 T15282 punct ),Miwa
R4836 T15448 T15446 nsubj findings,demonstrate
R4837 T15450 T15451 mark that,implicated
R4838 T15287 T15211 punct .,is
R4839 T15451 T15446 ccomp implicated,demonstrate
R4840 T15452 T15451 nsubjpass Apcs,implicated
R4841 T15289 T15290 prep In,described
R4842 T15453 T15451 auxpass is,implicated
R4843 T15454 T15451 neg not,implicated
R4844 T15455 T15451 prep in,implicated
R4845 T15456 T15457 det the,processing
R4846 T15457 T15455 pobj processing,in
R4847 T15291 T15292 det each,case
R4848 T15458 T15457 prep of,processing
R4849 T15459 T15458 pobj autoantigens,of
R4850 T15460 T15451 punct ", ",implicated
R4851 T15461 T15462 mark as,suggested
R4852 T15462 T15451 advcl suggested,implicated
R4853 T15463 T15462 nsubjpass it,suggested
R4854 T15464 T15462 aux had,suggested
R4855 T15292 T15289 pobj case,In
R4856 T15465 T15462 advmod previously,suggested
R4857 T15466 T15462 auxpass been,suggested
R4858 T15467 T15449 punct ", ",indicate
R4859 T15293 T15290 punct ", ",described
R4860 T15468 T15449 nsubj they,indicate
R4861 T15469 T15470 mark that,play
R4862 T15470 T15449 ccomp play,indicate
R4863 T15506 T15505 prep to,related
R4864 T15471 T15470 nsubj Apcs,play
R4865 T15472 T15470 aux might,play
R4866 T15473 T15470 advmod still,play
R4867 T15474 T15475 det an,role
R4868 T15507 T15506 pobj Apcs,to
R4869 T15475 T15470 dobj role,play
R4870 T15476 T15475 amod important,role
R4871 T15508 T15484 punct ", ",shown
R4872 T15477 T15475 amod protective,role
R4873 T15478 T15470 prep in,play
R4874 T15509 T15484 aux has,shown
R4875 T15510 T15484 auxpass been,shown
R4876 T15479 T15480 compound lupus,nephritis
R4877 T15480 T15478 pobj nephritis,in
R4878 T15511 T15512 aux to,delay
R4879 T15481 T15449 punct .,indicate
R4880 T15512 T15484 xcomp delay,shown
R4881 T15483 T15484 prep In,shown
R4882 T15485 T15483 pobj support,In
R4883 T15513 T15514 det the,onset
R4884 T15486 T15485 prep of,support
R4885 T15487 T15486 pobj this,of
R4886 T15514 T15512 dobj onset,delay
R4887 T15488 T15484 punct ", ",shown
R4888 T15489 T15490 det the,expression
R4889 T15490 T15484 nsubjpass expression,shown
R4890 T15515 T15514 cc and,onset
R4891 T15491 T15490 prep of,expression
R4892 T15492 T15493 det the,protein
R4893 T15493 T15491 pobj protein,of
R4894 T15516 T15514 conj severity,onset
R4895 T15494 T15493 amod human,protein
R4896 T15495 T15496 npadvmod C,reactive
R4897 T15496 T15493 amod reactive,protein
R4898 T15517 T15514 prep of,onset
R4899 T15497 T15496 punct -,reactive
R4900 T15518 T15519 compound lupus,nephritis
R4901 T15498 T15493 punct ", ",protein
R4902 T15499 T15500 det an,protein
R4903 T15500 T15493 appos protein,protein
R4904 T15501 T15502 amod acute,phase
R4905 T15502 T15500 compound phase,protein
R4906 T15519 T15517 pobj nephritis,of
R4907 T15503 T15502 punct -,phase
R4908 T15504 T15505 advmod closely,related
R4909 T15520 T15512 prep in,delay
R4910 T15505 T15500 amod related,protein
R4911 T15521 T15522 det the,strain
R4912 T15522 T15520 pobj strain,in
R4913 T15523 T15524 compound NZB,W
R4914 T15612 T15580 prep in,lay
R4915 T15613 T15614 det the,interactions
R4916 T15614 T15612 pobj interactions,in
R4917 T15524 T15522 compound W,strain
R4918 T15615 T15614 amod numerous,interactions
R4919 T15616 T15615 cc and,numerous
R4920 T15525 T15524 punct /,W
R4921 T15617 T15615 conj complex,numerous
R4922 T15618 T15614 amod synergistic,interactions
R4923 T15526 T15512 prep by,delay
R4924 T15619 T15618 cc and,synergistic
R4925 T15620 T15618 conj counteractive,synergistic
R4926 T15621 T15614 prep between,interactions
R4927 T15527 T15526 pcomp preventing,by
R4928 T15622 T15623 nummod 129,genes
R4929 T15623 T15621 pobj genes,between
R4930 T15624 T15622 cc and,129
R4931 T15528 T15529 det the,deposition
R4932 T15625 T15622 conj C57BL,129
R4933 T15626 T15625 punct /,C57BL
R4934 T15627 T15625 nummod 6,C57BL
R4935 T15529 T15527 dobj deposition,preventing
R4936 T15628 T15623 acl involved,genes
R4937 T15629 T15628 prep in,involved
R4938 T15530 T15529 prep of,deposition
R4939 T15630 T15631 compound self,tolerance
R4940 T15631 T15629 pobj tolerance,in
R4941 T15632 T15631 punct -,tolerance
R4942 T15531 T15532 amod immune,complexes
R4943 T15633 T15631 cc and,tolerance
R4944 T15634 T15635 compound end,damage
R4945 T15532 T15530 pobj complexes,of
R4946 T15635 T15631 conj damage,tolerance
R4947 T15636 T15635 compound organ,damage
R4948 T15637 T15580 punct .,lay
R4949 T15533 T15527 prep in,preventing
R4950 T15639 T15640 advmod Thus,required
R4951 T15534 T15535 det the,cortex
R4952 T15641 T15640 punct ", ",required
R4953 T15642 T15643 mark whilst,is
R4954 T15643 T15640 advcl is,required
R4955 T15644 T15645 det the,lack
R4956 T15645 T15643 nsubj lack,is
R4957 T15646 T15645 prep of,lack
R4958 T15535 T15533 pobj cortex,in
R4959 T15647 T15648 compound lupus,nephritis
R4960 T15648 T15646 pobj nephritis,of
R4961 T15649 T15645 prep in,lack
R4962 T15536 T15535 amod renal,cortex
R4963 T15650 T15651 det the,mice
R4964 T15651 T15649 pobj mice,in
R4965 T15537 T15538 punct (,Szalai
R4966 T15652 T15651 amod congenic,mice
R4967 T15653 T15643 acomp consistent,is
R4968 T15654 T15653 prep with,consistent
R4969 T15538 T15512 meta Szalai,delay
R4970 T15655 T15656 det the,need
R4971 T15656 T15654 pobj need,with
R4972 T15657 T15656 prep for,need
R4973 T15539 T15538 nmod et,Szalai
R4974 T15658 T15659 amod multiple,genes
R4975 T15659 T15657 pobj genes,for
R4976 T15540 T15538 nmod al.,Szalai
R4977 T15660 T15659 compound susceptibility,genes
R4978 T15661 T15656 prep for,need
R4979 T15662 T15663 det the,expression
R4980 T15541 T15538 nummod 2003,Szalai
R4981 T15663 T15661 pobj expression,for
R4982 T15664 T15663 amod full,expression
R4983 T15665 T15663 prep of,expression
R4984 T15542 T15538 punct ),Szalai
R4985 T15543 T15484 punct .,shown
R4986 T15666 T15665 pobj lupus,of
R4987 T15545 T15546 advcl Consistent,reported
R4988 T15667 T15640 punct ", ",required
R4989 T15668 T15669 amod further,studies
R4990 T15669 T15640 nsubjpass studies,required
R4991 T15670 T15640 aux will,required
R4992 T15547 T15545 prep with,Consistent
R4993 T15671 T15640 auxpass be,required
R4994 T15672 T15673 aux to,elucidate
R4995 T15673 T15640 advcl elucidate,required
R4996 T15674 T15673 advmod fully,elucidate
R4997 T15548 T15547 pobj this,with
R4998 T15675 T15676 det the,role
R4999 T15676 T15673 dobj role,elucidate
R5000 T15549 T15546 punct ", ",reported
R5001 T15677 T15676 prep of,role
R5002 T15678 T15677 pobj Apcs,of
R5003 T15679 T15676 prep in,role
R5004 T15550 T15551 det a,polymorphism
R5005 T15680 T15681 det the,pathogenesis
R5006 T15681 T15679 pobj pathogenesis,in
R5007 T15682 T15681 prep of,pathogenesis
R5008 T15683 T15684 amod renal,damage
R5009 T15684 T15682 pobj damage,of
R5010 T15551 T15546 nsubjpass polymorphism,reported
R5011 T15685 T15640 punct .,required
R5012 T15687 T15688 prep In,demonstrate
R5013 T15552 T15551 acl associated,polymorphism
R5014 T15689 T15687 pobj summary,In
R5015 T15553 T15552 prep with,associated
R5016 T15690 T15688 punct ", ",demonstrate
R5017 T15691 T15692 poss our,findings
R5018 T15692 T15688 nsubj findings,demonstrate
R5019 T15554 T15555 amod reduced,level
R5020 T15693 T15694 det the,impact
R5021 T15694 T15688 dobj impact,demonstrate
R5022 T15555 T15553 pobj level,with
R5023 T15695 T15694 prep of,impact
R5024 T15696 T15697 amod epistatic,interactions
R5025 T15697 T15695 pobj interactions,of
R5026 T15556 T15555 amod basal,level
R5027 T15698 T15697 prep between,interactions
R5028 T15699 T15700 nummod 129,C57BL
R5029 T15557 T15555 prep of,level
R5030 T15700 T15702 nmod C57BL,genomes
R5031 T15701 T15700 cc and,C57BL
R5032 T15702 T15698 pobj genomes,between
R5033 T15558 T15559 npadvmod C,reactive
R5034 T15703 T15700 punct /,C57BL
R5035 T15704 T15700 nummod 6,C57BL
R5036 T15705 T15694 prep on,impact
R5037 T15559 T15561 amod reactive,protein
R5038 T15706 T15707 det the,development
R5039 T15707 T15705 pobj development,on
R5040 T15708 T15707 prep of,development
R5041 T15560 T15559 punct -,reactive
R5042 T15709 T15708 pobj SLE,of
R5043 T15710 T15688 cc and,demonstrate
R5044 T15561 T15557 pobj protein,of
R5045 T15711 T15688 conj illustrate,demonstrate
R5046 T15712 T15713 advmod how,lead
R5047 T15713 T15711 ccomp lead,illustrate
R5048 T15562 T15546 aux has,reported
R5049 T15714 T15715 det these,effects
R5050 T15715 T15713 nsubj effects,lead
R5051 T15563 T15546 auxpass been,reported
R5052 T15716 T15717 compound background,gene
R5053 T15717 T15715 compound gene,effects
R5054 T15564 T15565 aux to,linked
R5055 T15565 T15546 xcomp linked,reported
R5056 T15718 T15713 aux may,lead
R5057 T15566 T15565 auxpass be,linked
R5058 T15719 T15713 prep to,lead
R5059 T15720 T15721 amod incorrect,interpretations
R5060 T15721 T15719 pobj interpretations,to
R5061 T15722 T15723 advmod when,analysing
R5062 T15723 T15713 advcl analysing,lead
R5063 T15567 T15565 prep to,linked
R5064 T15724 T15725 det the,phenotype
R5065 T15725 T15723 dobj phenotype,analysing
R5066 T15726 T15725 amod autoimmune,phenotype
R5067 T15568 T15567 pobj SLE,to
R5068 T15727 T15725 prep of,phenotype
R5069 T15728 T15729 amod specific,disruptions
R5070 T15569 T15565 prep in,linked
R5071 T15729 T15727 pobj disruptions,of
R5072 T15730 T15729 amod genetic,disruptions
R5073 T15731 T15688 punct .,demonstrate
R5074 T15570 T15569 pobj humans,in
R5075 T15571 T15572 punct (,Russell
R5076 T15572 T15565 meta Russell,linked
R5077 T15573 T15572 nmod et,Russell
R5078 T15574 T15572 nmod al.,Russell
R5079 T15575 T15572 nummod 2004,Russell
R5080 T15576 T15572 punct ),Russell
R5081 T15577 T15546 punct .,reported
R5082 T15579 T15580 advmod However,lay
R5083 T15581 T15580 punct ", ",lay
R5084 T15582 T15583 mark as,carried
R5085 T15583 T15580 advcl carried,lay
R5086 T15584 T15585 det the,mice
R5087 T15585 T15583 nsubj mice,carried
R5088 T15586 T15585 amod congenic,mice
R5089 T15587 T15585 cc and,mice
R5090 T15588 T15589 det the,mice
R5091 T15589 T15585 conj mice,mice
R5092 T15590 T15589 nmod Apcs,mice
R5093 T15591 T15590 punct −,Apcs
R5094 T15592 T15590 punct /,Apcs
R5095 T15593 T15590 punct −,Apcs
R5096 T15594 T15595 amod similar,regions
R5097 T15595 T15583 dobj regions,carried
R5098 T15596 T15594 cc but,similar
R5099 T15597 T15596 neg not,but
R5100 T15598 T15594 conj identical,similar
R5101 T15599 T15595 nummod 129,regions
R5102 T15600 T15583 prep on,carried
R5103 T15601 T15600 pobj Chromosome,on
R5104 T15602 T15601 nummod 1,Chromosome
R5105 T15603 T15580 punct ", ",lay
R5106 T15604 T15605 det an,explanation
R5107 T15605 T15580 nsubj explanation,lay
R5108 T15606 T15605 amod alternative,explanation
R5109 T15607 T15605 prep for,explanation
R5110 T15608 T15609 poss our,findings
R5111 T15609 T15607 pobj findings,for
R5112 T15610 T15580 aux may,lay
R5113 T15611 T15580 advmod still,lay
R5115 T16670 T16669 punct .,Mice
R5116 T16672 T16673 predet All,mice
R5117 T16673 T16675 nsubj mice,were
R5118 T16674 T16673 det the,mice
R5119 T16676 T16675 attr females,were
R5120 T16677 T16675 punct .,were
R5121 T16679 T16680 amod Wild,type
R5122 T16680 T16682 nsubjpass type,bred
R5123 T16681 T16680 punct -,type
R5124 T16683 T16680 appos C57BL,type
R5125 T16684 T16683 punct /,C57BL
R5126 T16685 T16683 nummod 6,C57BL
R5127 T16686 T16683 cc and,C57BL
R5128 T16687 T16688 compound 129,Sv
R5129 T16688 T16683 conj Sv,C57BL
R5130 T16689 T16688 punct /,Sv
R5131 T16690 T16688 punct (,Sv
R5132 T16691 T16688 appos 129S6,Sv
R5133 T16692 T16691 punct ", ",129S6
R5134 T16693 T16691 prep according,129S6
R5135 T16694 T16693 prep to,according
R5136 T16695 T16696 det the,nomenclature
R5137 T16696 T16694 pobj nomenclature,to
R5138 T16697 T16696 amod revised,nomenclature
R5139 T16698 T16688 punct ),Sv
R5140 T16699 T16682 auxpass were,bred
R5141 T16700 T16682 cc and,bred
R5142 T16701 T16682 conj maintained,bred
R5143 T16702 T16701 prep in,maintained
R5144 T16703 T16704 det the,facility
R5145 T16704 T16702 pobj facility,in
R5146 T16705 T16706 compound animal,care
R5147 T16706 T16704 compound care,facility
R5148 T16707 T16701 prep at,maintained
R5149 T16708 T16709 compound Imperial,College
R5150 T16709 T16707 pobj College,at
R5151 T16710 T16709 punct ", ",College
R5152 T16711 T16709 npadvmod London,College
R5153 T16712 T16709 punct ", ",College
R5154 T16713 T16714 compound United,Kingdom
R5155 T16714 T16709 npadvmod Kingdom,College
R5156 T16715 T16682 punct .,bred
R5157 T16717 T16718 punct (,mice
R5158 T16718 T16726 nsubjpass mice,generated
R5159 T16719 T16718 nummod 129,mice
R5160 T16720 T16719 punct ×,129
R5161 T16721 T16719 appos C57BL,129
R5162 T16722 T16721 punct /,C57BL
R5163 T16723 T16721 nummod 6,C57BL
R5164 T16724 T16718 punct ),mice
R5165 T16725 T16718 compound F1,mice
R5166 T16727 T16726 auxpass were,generated
R5167 T16728 T16726 prep by,generated
R5168 T16729 T16728 pcomp intercrossing,by
R5169 T16730 T16731 det the,strains
R5170 T16731 T16729 dobj strains,intercrossing
R5171 T16732 T16731 nummod two,strains
R5172 T16733 T16734 amod wild,type
R5173 T16734 T16731 compound type,strains
R5174 T16735 T16734 punct -,type
R5175 T16736 T16726 cc and,generated
R5176 T16737 T16738 punct (,mice
R5177 T16738 T16726 conj mice,generated
R5178 T16739 T16738 nummod 129,mice
R5179 T16740 T16739 punct ×,129
R5180 T16741 T16739 appos C57BL,129
R5181 T16742 T16741 punct /,C57BL
R5182 T16743 T16741 nummod 6,C57BL
R5183 T16744 T16738 punct ),mice
R5184 T16745 T16738 compound F2,mice
R5185 T16746 T16738 prep by,mice
R5186 T16747 T16746 pcomp interbreeding,by
R5187 T16748 T16749 det the,mice
R5188 T16749 T16747 dobj mice,interbreeding
R5189 T16750 T16749 punct (,mice
R5190 T16751 T16749 nummod 129,mice
R5191 T16752 T16751 punct ×,129
R5192 T16753 T16751 appos C57BL,129
R5193 T16754 T16753 punct /,C57BL
R5194 T16755 T16753 nummod 6,C57BL
R5195 T16756 T16749 punct ),mice
R5196 T16757 T16749 compound F1,mice
R5197 T16758 T16738 punct .,mice
R5198 T16760 T16761 det The,mice
R5199 T16761 T16766 nsubjpass mice,generated
R5200 T16762 T16761 nmod Apcs,mice
R5201 T16763 T16762 punct −,Apcs
R5202 T16764 T16762 punct /,Apcs
R5203 T16765 T16762 punct −,Apcs
R5204 T16767 T16766 auxpass were,generated
R5205 T16768 T16769 mark as,reported
R5206 T16769 T16766 advcl reported,generated
R5207 T16770 T16769 advmod previously,reported
R5208 T16771 T16772 punct (,Botto
R5209 T16772 T16769 meta Botto,reported
R5210 T16773 T16772 nmod et,Botto
R5211 T16774 T16772 nmod al.,Botto
R5212 T16775 T16772 nummod 1997,Botto
R5213 T16776 T16772 punct ),Botto
R5214 T16777 T16766 punct ", ",generated
R5215 T16778 T16766 cc and,generated
R5216 T16779 T16780 det the,mice
R5217 T16780 T16794 nsubjpass mice,generated
R5218 T16781 T16782 punct (,F2
R5219 T16782 T16780 nmod F2,mice
R5220 T16783 T16782 nummod 129,F2
R5221 T16784 T16783 punct ×,129
R5222 T16785 T16783 appos C57BL,129
R5223 T16786 T16785 punct /,C57BL
R5224 T16787 T16785 nummod 6,C57BL
R5225 T16788 T16782 punct ),F2
R5226 T16789 T16782 punct .,F2
R5227 T16790 T16782 appos Apcs,F2
R5228 T16791 T16790 punct −,Apcs
R5229 T16792 T16790 punct /,Apcs
R5230 T16793 T16790 punct −,Apcs
R5231 T16794 T16766 conj generated,generated
R5232 T16795 T16794 auxpass were,generated
R5233 T16796 T16794 prep by,generated
R5234 T16797 T16796 pcomp intercrossing,by
R5235 T16798 T16799 nmod Apcs,mice
R5236 T16799 T16797 dobj mice,intercrossing
R5237 T16800 T16798 punct −,Apcs
R5238 T16801 T16798 punct /,Apcs
R5239 T16802 T16798 punct −,Apcs
R5240 T16803 T16797 prep on,intercrossing
R5241 T16804 T16805 det the,background
R5242 T16805 T16803 pobj background,on
R5243 T16806 T16805 nummod 129,background
R5244 T16807 T16805 amod genetic,background
R5245 T16808 T16797 prep with,intercrossing
R5246 T16809 T16810 nmod Apcs,animals
R5247 T16810 T16808 pobj animals,with
R5248 T16811 T16809 punct −,Apcs
R5249 T16812 T16809 punct /,Apcs
R5250 T16813 T16809 punct −,Apcs
R5251 T16814 T16810 acl backcrossed,animals
R5252 T16815 T16814 prep onto,backcrossed
R5253 T16816 T16815 pobj C57BL,onto
R5254 T16817 T16816 punct /,C57BL
R5255 T16818 T16816 nummod 6,C57BL
R5256 T16819 T16814 prep for,backcrossed
R5257 T16820 T16821 nummod ten,generations
R5258 T16821 T16819 pobj generations,for
R5259 T16822 T16794 punct .,generated
R5260 T16824 T16825 det A,total
R5261 T16825 T16826 nsubjpass total,produced
R5262 T16827 T16825 prep of,total
R5263 T16828 T16829 nummod 141,F2
R5264 T16829 T16827 pobj F2,of
R5265 T16830 T16829 punct (,F2
R5266 T16831 T16829 nummod 129,F2
R5267 T16832 T16831 punct ×,129
R5268 T16833 T16831 appos C57BL,129
R5269 T16834 T16833 punct /,C57BL
R5270 T16835 T16833 nummod 6,C57BL
R5271 T16836 T16829 punct ),F2
R5272 T16837 T16829 cc and,F2
R5273 T16838 T16839 nummod 158,F2
R5274 T16839 T16847 nmod F2,mice
R5275 T16840 T16839 punct (,F2
R5276 T16841 T16842 nummod 129,C57BL
R5277 T16842 T16839 nmod C57BL,F2
R5278 T16843 T16842 punct ×,C57BL
R5279 T16844 T16842 punct /,C57BL
R5280 T16845 T16842 nummod 6,C57BL
R5281 T16846 T16839 punct ),F2
R5282 T16847 T16829 conj mice,F2
R5283 T16848 T16839 punct .,F2
R5284 T16849 T16839 appos Apcs,F2
R5285 T16850 T16849 punct −,Apcs
R5286 T16851 T16849 punct /,Apcs
R5287 T16852 T16849 punct −,Apcs
R5288 T16853 T16847 amod female,mice
R5289 T16854 T16826 auxpass were,produced
R5290 T16855 T16826 cc and,produced
R5291 T16856 T16826 conj monitored,produced
R5292 T16857 T16856 prep for,monitored
R5293 T16858 T16859 nummod 1,y
R5294 T16859 T16857 pobj y,for
R5295 T16860 T16826 punct .,produced
R5296 T16862 T16863 amod Wild,type
R5297 T16863 T16865 nmod type,mice
R5298 T16864 T16863 punct -,type
R5299 T16865 T16877 nsubjpass mice,generated
R5300 T16866 T16865 amod congenic,mice
R5301 T16867 T16865 nmod C57BL,mice
R5302 T16868 T16867 punct /,C57BL
R5303 T16869 T16867 nummod 6,C57BL
R5304 T16870 T16867 punct .,C57BL
R5305 T16871 T16867 appos 129,C57BL
R5306 T16872 T16873 punct (,D1Mit105
R5307 T16873 T16871 parataxis D1Mit105,129
R5308 T16874 T16875 punct –,223
R5309 T16875 T16873 prep 223,D1Mit105
R5310 T16876 T16873 punct ),D1Mit105
R5311 T16878 T16877 auxpass were,generated
R5312 T16879 T16877 prep by,generated
R5313 T16880 T16879 pcomp backcrossing,by
R5314 T16881 T16882 det the,interval
R5315 T16882 T16880 dobj interval,backcrossing
R5316 T16883 T16882 nummod 129,interval
R5317 T16884 T16882 prep between,interval
R5318 T16885 T16886 compound microsatellites,D1Mit105
R5319 T16886 T16884 pobj D1Mit105,between
R5320 T16887 T16886 cc and,D1Mit105
R5321 T16888 T16886 conj D1Mit223,D1Mit105
R5322 T16889 T16890 punct (,cM
R5323 T16890 T16886 parataxis cM,D1Mit105
R5324 T16891 T16890 nummod 80,cM
R5325 T16892 T16890 prep to,cM
R5326 T16893 T16894 nummod 106,cM
R5327 T16894 T16892 pobj cM,to
R5328 T16895 T16890 punct ),cM
R5329 T16896 T16880 prep onto,backcrossing
R5330 T16897 T16898 det the,strain
R5331 T16898 T16896 pobj strain,onto
R5332 T16899 T16898 nmod C57BL,strain
R5333 T16900 T16899 punct /,C57BL
R5334 T16901 T16899 nummod 6,C57BL
R5335 T16902 T16877 punct .,generated
R5336 T16904 T16905 amod Inherited,regions
R5337 T16905 T16907 nsubjpass regions,mapped
R5338 T16906 T16905 nummod 129,regions
R5339 T16908 T16907 auxpass were,mapped
R5340 T16909 T16907 prep with,mapped
R5341 T16910 T16911 compound microsatellite,markers
R5342 T16911 T16909 pobj markers,with
R5343 T16912 T16911 amod polymorphic,markers
R5344 T16913 T16912 prep between,polymorphic
R5345 T16914 T16915 nummod 129,mice
R5346 T16915 T16913 pobj mice,between
R5347 T16916 T16914 cc and,129
R5348 T16917 T16914 conj C57BL,129
R5349 T16918 T16917 punct /,C57BL
R5350 T16919 T16917 nummod 6,C57BL
R5351 T16920 T16921 punct (,see
R5352 T16921 T16915 parataxis see,mice
R5353 T16922 T16921 advmod below,see
R5354 T16923 T16921 punct ),see
R5355 T16924 T16907 punct .,mapped
R5356 T16926 T16927 prep After,intercrossed
R5357 T16928 T16929 nummod seven,generations
R5358 T16929 T16926 pobj generations,After
R5359 T16930 T16929 prep of,generations
R5360 T16931 T16930 pobj backcrossing,of
R5361 T16932 T16927 punct ", ",intercrossed
R5362 T16933 T16927 nsubjpass siblings,intercrossed
R5363 T16934 T16927 auxpass were,intercrossed
R5364 T16935 T16936 aux to,generate
R5365 T16936 T16927 advcl generate,intercrossed
R5366 T16937 T16938 nmod C57BL,mice
R5367 T16938 T16936 dobj mice,generate
R5368 T16939 T16937 punct /,C57BL
R5369 T16940 T16937 nummod 6,C57BL
R5370 T16941 T16937 punct .,C57BL
R5371 T16942 T16937 appos 129,C57BL
R5372 T16943 T16944 punct (,D1Mit105
R5373 T16944 T16942 parataxis D1Mit105,129
R5374 T16945 T16946 punct –,223
R5375 T16946 T16944 prep 223,D1Mit105
R5376 T16947 T16944 punct ),D1Mit105
R5377 T16948 T16938 amod congenic,mice
R5378 T16949 T16938 amod homozygous,mice
R5379 T16950 T16949 prep for,homozygous
R5380 T16951 T16952 det the,interval
R5381 T16952 T16950 pobj interval,for
R5382 T16953 T16952 nummod 129,interval
R5383 T16954 T16952 nmod Chromosome,interval
R5384 T16955 T16954 nummod 1,Chromosome
R5385 T16956 T16927 punct .,intercrossed
R5386 T16958 T16959 amod Inside,markers
R5387 T16959 T16961 nsubjpass markers,used
R5388 T16960 T16959 nummod 129,markers
R5389 T16962 T16959 prep at,markers
R5390 T16963 T16964 nmod positions,cM
R5391 T16964 T16962 pobj cM,at
R5392 T16965 T16964 nummod 81.6,cM
R5393 T16966 T16967 punct (,D1Mit159
R5394 T16967 T16964 parataxis D1Mit159,cM
R5395 T16968 T16967 punct ),D1Mit159
R5396 T16969 T16964 cc and,cM
R5397 T16970 T16971 nummod 105,cM
R5398 T16971 T16964 conj cM,cM
R5399 T16972 T16973 punct (,D1Mit17
R5400 T16973 T16971 parataxis D1Mit17,cM
R5401 T16974 T16973 punct ),D1Mit17
R5402 T16975 T16964 punct ", ",cM
R5403 T16976 T16964 advmod respectively,cM
R5404 T16977 T16959 punct ", ",markers
R5405 T16978 T16959 cc and,markers
R5406 T16979 T16980 det an,marker
R5407 T16980 T16959 conj marker,markers
R5408 T16981 T16980 amod outside,marker
R5409 T16982 T16980 nmod C57BL,marker
R5410 T16983 T16982 punct /,C57BL
R5411 T16984 T16982 nummod 6,C57BL
R5412 T16985 T16980 prep at,marker
R5413 T16986 T16987 compound position,74.3cM
R5414 T16987 T16985 pobj 74.3cM,at
R5415 T16988 T16989 punct (,D1Mit159
R5416 T16989 T16987 parataxis D1Mit159,74.3cM
R5417 T16990 T16989 punct ),D1Mit159
R5418 T16991 T16961 auxpass were,used
R5419 T16992 T16993 aux to,define
R5420 T16993 T16961 advcl define,used
R5421 T16994 T16993 advmod further,define
R5422 T16995 T16996 det the,interval
R5423 T16996 T16993 dobj interval,define
R5424 T16997 T16961 punct .,used
R5425 T16999 T17000 prep In,mapped
R5426 T17001 T17002 det the,mice
R5427 T17002 T16999 pobj mice,In
R5428 T17003 T17002 nmod C57BL,mice
R5429 T17004 T17003 punct /,C57BL
R5430 T17005 T17003 nummod 6,C57BL
R5431 T17006 T17003 punct .,C57BL
R5432 T17007 T17003 appos Apcs,C57BL
R5433 T17008 T17007 punct −,Apcs
R5434 T17009 T17007 punct /,Apcs
R5435 T17010 T17007 punct −,Apcs
R5436 T17011 T17002 punct (,mice
R5437 T17012 T17002 acl backcrossed,mice
R5438 T17013 T17012 prep onto,backcrossed
R5439 T17014 T17013 pobj C57BL,onto
R5440 T17015 T17014 punct /,C57BL
R5441 T17016 T17014 nummod 6,C57BL
R5442 T17017 T17012 prep for,backcrossed
R5443 T17018 T17019 nummod ten,generations
R5444 T17019 T17017 pobj generations,for
R5445 T17020 T17002 punct ),mice
R5446 T17021 T17000 punct ", ",mapped
R5447 T17022 T17023 det the,genome
R5448 T17023 T17000 nsubjpass genome,mapped
R5449 T17024 T17023 nummod 129,genome
R5450 T17025 T17023 prep around,genome
R5451 T17026 T17027 det the,locus
R5452 T17027 T17025 pobj locus,around
R5453 T17028 T17027 compound Apcs,locus
R5454 T17029 T17000 auxpass was,mapped
R5455 T17030 T17000 prep as,mapped
R5456 T17031 T17032 det a,segment
R5457 T17032 T17030 pobj segment,as
R5458 T17033 T17032 prep from,segment
R5459 T17034 T17035 nummod 87.9,cM
R5460 T17035 T17033 pobj cM,from
R5461 T17036 T17037 punct (,D1Mit15
R5462 T17037 T17035 parataxis D1Mit15,cM
R5463 T17038 T17037 punct ),D1Mit15
R5464 T17039 T17033 prep to,from
R5465 T17040 T17041 nummod 105,cM
R5466 T17041 T17039 pobj cM,to
R5467 T17042 T17043 punct (,D1Mit17
R5468 T17043 T17041 parataxis D1Mit17,cM
R5469 T17044 T17043 punct ),D1Mit17
R5470 T17045 T17000 punct .,mapped
R5471 T17047 T17048 prep In,were
R5472 T17049 T17050 det this,analysis
R5473 T17050 T17047 pobj analysis,In
R5474 T17051 T17048 punct ", ",were
R5475 T17052 T17053 det the,markers
R5476 T17053 T17048 nsubj markers,were
R5477 T17054 T17053 amod inside,markers
R5478 T17055 T17053 nummod 129,markers
R5479 T17056 T17048 prep at,were
R5480 T17057 T17058 nmod positions,cM
R5481 T17058 T17056 pobj cM,at
R5482 T17059 T17058 nummod 93,cM
R5483 T17060 T17061 punct (,D1Mit36
R5484 T17061 T17058 parataxis D1Mit36,cM
R5485 T17062 T17061 punct ),D1Mit36
R5486 T17063 T17058 cc and,cM
R5487 T17064 T17065 nummod 99.7,cM
R5488 T17065 T17058 conj cM,cM
R5489 T17066 T17067 punct (,D1Mit115
R5490 T17067 T17065 parataxis D1Mit115,cM
R5491 T17068 T17067 punct ),D1Mit115
R5492 T17069 T17048 cc and,were
R5493 T17070 T17071 det the,markers
R5494 T17071 T17048 conj markers,were
R5495 T17072 T17071 amod outside,markers
R5496 T17073 T17071 nmod C57BL,markers
R5497 T17074 T17073 punct /,C57BL
R5498 T17075 T17073 nummod 6,C57BL
R5499 T17076 T17071 prep at,markers
R5500 T17077 T17078 nmod positions,cM
R5501 T17078 T17076 pobj cM,at
R5502 T17079 T17078 nummod 81.6,cM
R5503 T17080 T17081 punct (,D1Mit159
R5504 T17081 T17078 parataxis D1Mit159,cM
R5505 T17082 T17081 punct ),D1Mit159
R5506 T17083 T17078 cc and,cM
R5507 T17084 T17085 nummod 106,cM
R5508 T17085 T17078 conj cM,cM
R5509 T17086 T17087 punct (,D1Mit223
R5510 T17087 T17085 parataxis D1Mit223,cM
R5511 T17088 T17087 punct ),D1Mit223
R5512 T17089 T17071 punct .,markers
R5513 T17091 T17092 prep Along,followed
R5514 T17093 T17091 prep with,Along
R5515 T17094 T17095 nummod 28,mice
R5516 T17095 T17093 pobj mice,with
R5517 T17096 T17095 nmod C57BL,mice
R5518 T17097 T17096 punct /,C57BL
R5519 T17098 T17096 nummod 6,C57BL
R5520 T17099 T17096 punct .,C57BL
R5521 T17100 T17096 appos Apcs,C57BL
R5522 T17101 T17100 punct −,Apcs
R5523 T17102 T17100 punct /,Apcs
R5524 T17103 T17100 punct −,Apcs
R5525 T17104 T17095 cc and,mice
R5526 T17105 T17106 nummod 30,animals
R5527 T17106 T17095 conj animals,mice
R5528 T17107 T17106 nmod C57BL,animals
R5529 T17108 T17107 punct /,C57BL
R5530 T17109 T17107 nummod 6,C57BL
R5531 T17110 T17111 amod wild,type
R5532 T17111 T17106 compound type,animals
R5533 T17112 T17111 punct -,type
R5534 T17113 T17092 punct ", ",followed
R5535 T17114 T17115 nummod 26,mice
R5536 T17115 T17092 nsubjpass mice,followed
R5537 T17116 T17115 nmod C57BL,mice
R5538 T17117 T17116 punct /,C57BL
R5539 T17118 T17116 nummod 6,C57BL
R5540 T17119 T17116 punct .,C57BL
R5541 T17120 T17116 appos 129,C57BL
R5542 T17121 T17122 punct (,D1Mit105
R5543 T17122 T17120 parataxis D1Mit105,129
R5544 T17123 T17124 punct –,223
R5545 T17124 T17122 prep 223,D1Mit105
R5546 T17125 T17122 punct ),D1Mit105
R5547 T17126 T17115 amod female,mice
R5548 T17127 T17115 punct −,mice
R5549 T17128 T17115 punct /,mice
R5550 T17129 T17115 punct −,mice
R5551 T17130 T17092 auxpass were,followed
R5552 T17131 T17092 prep up,followed
R5553 T17132 T17131 prep to,up
R5554 T17133 T17134 nummod 1,y
R5555 T17134 T17132 pobj y,to
R5556 T17135 T17134 prep of,y
R5557 T17136 T17135 pobj age,of
R5558 T17137 T17092 punct .,followed
R5559 T17139 T17140 nsubjpass Animals,maintained
R5560 T17141 T17140 auxpass were,maintained
R5561 T17142 T17140 prep in,maintained
R5562 T17143 T17144 amod specific,conditions
R5563 T17144 T17142 pobj conditions,in
R5564 T17145 T17146 npadvmod pathogen,free
R5565 T17146 T17144 amod free,conditions
R5566 T17147 T17146 punct -,free
R5567 T17148 T17140 punct .,maintained
R5568 T17150 T17151 det All,procedures
R5569 T17151 T17153 nsubj procedures,were
R5570 T17152 T17151 compound animal,procedures
R5571 T17154 T17153 prep in,were
R5572 T17155 T17154 pobj accordance,in
R5573 T17156 T17155 prep with,accordance
R5574 T17157 T17158 amod institutional,guidelines
R5575 T17158 T17156 pobj guidelines,with
R5576 T17159 T17153 punct .,were
R5577 T17696 T17697 amod Serological,analyses
R5578 T17698 T17697 punct .,analyses
R5579 T17700 T17701 nsubjpass Sera,assayed
R5580 T17702 T17700 punct ", ",Sera
R5581 T17703 T17700 acl collected,Sera
R5582 T17704 T17703 prep at,collected
R5583 T17705 T17706 nummod 6,mo
R5584 T17706 T17704 pobj mo,at
R5585 T17707 T17705 cc and,6
R5586 T17708 T17705 conj 12,6
R5587 T17709 T17706 prep of,mo
R5588 T17710 T17709 pobj age,of
R5589 T17711 T17701 punct ", ",assayed
R5590 T17712 T17701 auxpass were,assayed
R5591 T17713 T17701 prep for,assayed
R5592 T17714 T17715 det the,presence
R5593 T17715 T17713 pobj presence,for
R5594 T17716 T17715 prep of,presence
R5595 T17717 T17716 pobj auto-Abs,of
R5596 T17718 T17701 punct .,assayed
R5597 T17720 T17721 nsubjpass Levels,sought
R5598 T17722 T17720 prep of,Levels
R5599 T17723 T17724 compound IgG,ANA
R5600 T17724 T17722 pobj ANA,of
R5601 T17725 T17721 auxpass were,sought
R5602 T17726 T17721 prep by,sought
R5603 T17727 T17728 amod indirect,immunofluorescence
R5604 T17728 T17726 pobj immunofluorescence,by
R5605 T17729 T17721 advcl using,sought
R5606 T17730 T17731 nmod Hep,cells
R5607 T17731 T17729 dobj cells,using
R5608 T17732 T17730 punct -,Hep
R5609 T17733 T17730 nummod 2,Hep
R5610 T17734 T17721 punct ", ",sought
R5611 T17735 T17721 cc and,sought
R5612 T17736 T17737 amod anti-dsDNA,Abs
R5613 T17737 T17738 nsubjpass Abs,detected
R5614 T17738 T17721 conj detected,sought
R5615 T17739 T17738 auxpass were,detected
R5616 T17740 T17738 prep by,detected
R5617 T17741 T17742 amod indirect,immunofluorescence
R5618 T17742 T17740 pobj immunofluorescence,by
R5619 T17743 T17742 prep on,immunofluorescence
R5620 T17744 T17745 compound Crithidia,luciliae
R5621 T17745 T17743 pobj luciliae,on
R5622 T17746 T17747 mark as,described
R5623 T17747 T17738 advcl described,detected
R5624 T17748 T17747 advmod previously,described
R5625 T17749 T17750 punct (,Mitchell
R5626 T17750 T17747 meta Mitchell,described
R5627 T17751 T17750 nmod et,Mitchell
R5628 T17752 T17750 nmod al.,Mitchell
R5629 T17753 T17750 nummod 2002,Mitchell
R5630 T17754 T17750 punct ),Mitchell
R5631 T17755 T17738 punct .,detected
R5632 T17757 T17758 compound Serum,samples
R5633 T17758 T17759 nsubjpass samples,screened
R5634 T17760 T17759 auxpass were,screened
R5635 T17761 T17759 prep at,screened
R5636 T17762 T17763 det a,dilution
R5637 T17763 T17761 pobj dilution,at
R5638 T17764 T17763 nummod 1,dilution
R5639 T17765 T17766 punct :,80
R5640 T17766 T17764 prep 80,1
R5641 T17767 T17768 punct (,ANA
R5642 T17768 T17764 parataxis ANA,1
R5643 T17769 T17768 punct ),ANA
R5644 T17770 T17764 cc or,1
R5645 T17771 T17764 conj 1,1
R5646 T17772 T17773 punct :,20
R5647 T17773 T17771 prep 20,1
R5648 T17774 T17775 punct (,anti-dsDNA
R5649 T17775 T17771 parataxis anti-dsDNA,1
R5650 T17776 T17775 punct ),anti-dsDNA
R5651 T17777 T17759 cc and,screened
R5652 T17778 T17779 det the,samples
R5653 T17779 T17781 nsubj samples,titrated
R5654 T17780 T17779 amod positive,samples
R5655 T17781 T17759 conj titrated,screened
R5656 T17782 T17781 prep to,titrated
R5657 T17783 T17782 pobj endpoint,to
R5658 T17784 T17781 punct .,titrated
R5659 T17786 T17787 nsubjpass Abs,measured
R5660 T17788 T17786 prep to,Abs
R5661 T17789 T17788 pobj ssDNA,to
R5662 T17790 T17789 cc and,ssDNA
R5663 T17791 T17789 conj anti-chromatin,ssDNA
R5664 T17792 T17787 auxpass were,measured
R5665 T17793 T17787 agent by,measured
R5666 T17794 T17793 pobj ELISA,by
R5667 T17795 T17787 punct ", ",measured
R5668 T17796 T17797 mark as,described
R5669 T17797 T17787 advcl described,measured
R5670 T17798 T17797 advmod previously,described
R5671 T17799 T17800 punct (,Mitchell
R5672 T17800 T17797 meta Mitchell,described
R5673 T17801 T17800 nmod et,Mitchell
R5674 T17802 T17800 nmod al.,Mitchell
R5675 T17803 T17800 nummod 2002,Mitchell
R5676 T17804 T17800 punct ),Mitchell
R5677 T17805 T17787 punct .,measured
R5678 T17807 T17808 nsubjpass Samples,screened
R5679 T17809 T17808 auxpass were,screened
R5680 T17810 T17808 prep at,screened
R5681 T17811 T17812 det a,dilution
R5682 T17812 T17810 pobj dilution,at
R5683 T17813 T17812 nummod 1,dilution
R5684 T17814 T17815 punct :,100
R5685 T17815 T17813 prep 100,1
R5686 T17816 T17808 punct ", ",screened
R5687 T17817 T17808 cc and,screened
R5688 T17818 T17819 det the,results
R5689 T17819 T17820 nsubjpass results,expressed
R5690 T17820 T17808 conj expressed,screened
R5691 T17821 T17820 auxpass were,expressed
R5692 T17822 T17820 prep in,expressed
R5693 T17823 T17824 amod arbitrary,units
R5694 T17824 T17822 pobj units,in
R5695 T17825 T17824 compound ELISA,units
R5696 T17826 T17824 punct (,units
R5697 T17827 T17824 appos AEUs,units
R5698 T17828 T17824 punct ),units
R5699 T17829 T17824 amod relative,units
R5700 T17830 T17829 prep to,relative
R5701 T17831 T17832 det a,sample
R5702 T17832 T17830 pobj sample,to
R5703 T17833 T17832 amod standard,sample
R5704 T17834 T17832 amod positive,sample
R5705 T17835 T17832 punct (,sample
R5706 T17836 T17832 acl derived,sample
R5707 T17837 T17836 prep from,derived
R5708 T17838 T17839 det an,mouse
R5709 T17839 T17837 pobj mouse,from
R5710 T17840 T17841 nmod MRL,Mp
R5711 T17841 T17839 nmod Mp,mouse
R5712 T17842 T17841 punct /,Mp
R5713 T17843 T17841 punct .,Mp
R5714 T17844 T17845 compound lpr,lpr
R5715 T17845 T17841 appos lpr,Mp
R5716 T17846 T17845 punct /,lpr
R5717 T17847 T17832 punct ),sample
R5718 T17848 T17832 punct ", ",sample
R5719 T17849 T17850 dep which,assigned
R5720 T17850 T17832 relcl assigned,sample
R5721 T17851 T17850 auxpass was,assigned
R5722 T17852 T17853 det a,value
R5723 T17853 T17850 dobj value,assigned
R5724 T17854 T17853 prep of,value
R5725 T17855 T17854 pobj 100,of
R5726 T17856 T17820 punct .,expressed
R5727 T17858 T17859 prep For,included
R5728 T17860 T17861 amod interplate,comparison
R5729 T17861 T17858 pobj comparison,For
R5730 T17862 T17859 punct ", ",included
R5731 T17863 T17864 amod serial,dilutions
R5732 T17864 T17859 nsubjpass dilutions,included
R5733 T17865 T17864 prep of,dilutions
R5734 T17866 T17867 det a,sample
R5735 T17867 T17865 pobj sample,of
R5736 T17868 T17867 amod positive,sample
R5737 T17869 T17867 compound control,sample
R5738 T17870 T17867 compound serum,sample
R5739 T17871 T17859 auxpass were,included
R5740 T17872 T17859 prep on,included
R5741 T17873 T17874 det each,plate
R5742 T17874 T17872 pobj plate,on
R5743 T17875 T17859 punct .,included
R5744 T17877 T17878 compound Apcs,levels
R5745 T17878 T17879 nsubjpass levels,assessed
R5746 T17880 T17879 auxpass were,assessed
R5747 T17881 T17879 prep by,assessed
R5748 T17882 T17881 pobj ELISA,by
R5749 T17883 T17879 advcl using,assessed
R5750 T17884 T17885 nmod sheep,Apcs
R5751 T17885 T17887 nmod Apcs,Abs
R5752 T17886 T17885 amod anti-mouse,Apcs
R5753 T17887 T17883 dobj Abs,using
R5754 T17888 T17885 cc and,Apcs
R5755 T17889 T17890 nmod rabbit,Apcs
R5756 T17890 T17885 conj Apcs,Apcs
R5757 T17891 T17890 amod anti-mouse,Apcs
R5758 T17892 T17893 punct (,Calbiochem
R5759 T17893 T17887 parataxis Calbiochem,Abs
R5760 T17894 T17893 punct ", ",Calbiochem
R5761 T17895 T17893 npadvmod Nottigham,Calbiochem
R5762 T17896 T17893 punct ", ",Calbiochem
R5763 T17897 T17898 compound United,Kingdom
R5764 T17898 T17893 npadvmod Kingdom,Calbiochem
R5765 T17899 T17893 punct ),Calbiochem
R5766 T17900 T17879 punct .,assessed
R5767 T17902 T17903 nsubjpass Samples,screened
R5768 T17904 T17903 auxpass were,screened
R5769 T17905 T17903 prep at,screened
R5770 T17906 T17907 det a,dilution
R5771 T17907 T17905 pobj dilution,at
R5772 T17908 T17907 nummod 1,dilution
R5773 T17909 T17910 punct :,"3,000"
R5774 T17910 T17908 prep "3,000",1
R5775 T17911 T17903 punct ", ",screened
R5776 T17912 T17903 cc and,screened
R5777 T17913 T17914 det the,results
R5778 T17914 T17915 nsubjpass results,expressed
R5779 T17915 T17903 conj expressed,screened
R5780 T17916 T17915 auxpass were,expressed
R5781 T17917 T17915 prep in,expressed
R5782 T17918 T17917 pobj milligrams,in
R5783 T17919 T17918 prep per,milligrams
R5784 T17920 T17919 pobj liters,per
R5785 T17921 T17915 punct ", ",expressed
R5786 T17922 T17915 advcl referring,expressed
R5787 T17923 T17922 prep to,referring
R5788 T17924 T17925 det a,curve
R5789 T17925 T17923 pobj curve,to
R5790 T17926 T17925 amod standard,curve
R5791 T17927 T17925 acl derived,curve
R5792 T17928 T17927 prep from,derived
R5793 T17929 T17930 det an,serum
R5794 T17930 T17928 pobj serum,from
R5795 T17931 T17932 amod acute,phase
R5796 T17932 T17930 compound phase,serum
R5797 T17933 T17932 punct -,phase
R5798 T17934 T17930 prep with,serum
R5799 T17935 T17936 det a,concentration
R5800 T17936 T17934 pobj concentration,with
R5801 T17937 T17936 amod known,concentration
R5802 T17938 T17936 prep of,concentration
R5803 T17939 T17938 pobj Apcs,of
R5804 T17940 T17941 punct (,Calbiochem
R5805 T17941 T17930 parataxis Calbiochem,serum
R5806 T17942 T17941 punct ),Calbiochem
R5807 T17943 T17915 punct .,expressed
R5808 T17945 T17946 nmod Apcs,serum
R5809 T17946 T17951 nsubjpass serum,included
R5810 T17947 T17945 punct −,Apcs
R5811 T17948 T17945 punct /,Apcs
R5812 T17949 T17945 punct −,Apcs
R5813 T17950 T17946 compound mouse,serum
R5814 T17952 T17951 auxpass was,included
R5815 T17953 T17951 prep as,included
R5816 T17954 T17955 det a,control
R5817 T17955 T17953 pobj control,as
R5818 T17956 T17955 amod negative,control
R5819 T17957 T17951 punct .,included
R5820 T18234 T18235 amod Histological,analysis
R5821 T18236 T18235 punct .,analysis
R5822 T18238 T18239 predet All,mice
R5823 T18239 T18241 nsubjpass mice,sacrificed
R5824 T18240 T18239 det the,mice
R5825 T18242 T18239 punct ", ",mice
R5826 T18243 T18239 prep except,mice
R5827 T18244 T18245 det the,few
R5828 T18245 T18243 pobj few,except
R5829 T18246 T18247 dep that,died
R5830 T18247 T18245 relcl died,few
R5831 T18248 T18247 prep before,died
R5832 T18249 T18250 det the,end
R5833 T18250 T18248 pobj end,before
R5834 T18251 T18250 prep of,end
R5835 T18252 T18253 det the,experiment
R5836 T18253 T18251 pobj experiment,of
R5837 T18254 T18241 punct ", ",sacrificed
R5838 T18255 T18241 auxpass were,sacrificed
R5839 T18256 T18241 prep at,sacrificed
R5840 T18257 T18258 nummod 1,y
R5841 T18258 T18256 pobj y,at
R5842 T18259 T18258 prep of,y
R5843 T18260 T18259 pobj age,of
R5844 T18261 T18241 punct ", ",sacrificed
R5845 T18262 T18241 cc and,sacrificed
R5846 T18263 T18264 compound kidney,portions
R5847 T18264 T18265 nsubjpass portions,fixed
R5848 T18265 T18241 conj fixed,sacrificed
R5849 T18266 T18265 auxpass were,fixed
R5850 T18267 T18265 prep in,fixed
R5851 T18268 T18269 poss Bouin,solution
R5852 T18269 T18267 pobj solution,in
R5853 T18270 T18268 case 's,Bouin
R5854 T18271 T18265 cc and,fixed
R5855 T18272 T18273 dep paraffin,embedded
R5856 T18273 T18265 conj embedded,fixed
R5857 T18274 T18265 punct ", ",fixed
R5858 T18275 T18265 cc and,fixed
R5859 T18276 T18277 nsubjpass sections,stained
R5860 T18277 T18265 conj stained,fixed
R5861 T18278 T18277 auxpass were,stained
R5862 T18279 T18277 prep with,stained
R5863 T18280 T18281 amod periodic,acid
R5864 T18281 T18279 pobj acid,with
R5865 T18282 T18281 punct –,acid
R5866 T18283 T18284 compound Schiff,reagent
R5867 T18284 T18281 appos reagent,acid
R5868 T18285 T18277 punct .,stained
R5869 T18287 T18288 amod Glomerular,histology
R5870 T18288 T18289 nsubjpass histology,graded
R5871 T18290 T18289 auxpass was,graded
R5872 T18291 T18289 prep in,graded
R5873 T18292 T18293 det a,fashion
R5874 T18293 T18291 pobj fashion,in
R5875 T18294 T18293 amod blinded,fashion
R5876 T18295 T18296 mark as,follows
R5877 T18296 T18289 advcl follows,graded
R5878 T18297 T18289 punct : ,graded
R5879 T18298 T18299 dep grade,hypercellularity
R5880 T18299 T18289 dep hypercellularity,graded
R5881 T18300 T18298 nummod 0,grade
R5882 T18301 T18298 punct ", ",grade
R5883 T18302 T18298 amod normal,grade
R5884 T18303 T18299 punct ;,hypercellularity
R5885 T18304 T18305 dep grade,hypercellularity
R5886 T18305 T18299 dep hypercellularity,hypercellularity
R5887 T18306 T18304 nummod 1,grade
R5888 T18307 T18305 punct ", ",hypercellularity
R5889 T18308 T18305 acl involving,hypercellularity
R5890 T18309 T18310 amod greater,50
R5891 T18310 T18312 nummod 50,%
R5892 T18311 T18310 quantmod than,50
R5893 T18312 T18308 dobj %,involving
R5894 T18313 T18312 prep of,%
R5895 T18314 T18315 det the,tuft
R5896 T18315 T18313 pobj tuft,of
R5897 T18316 T18315 amod glomerular,tuft
R5898 T18317 T18308 prep in,involving
R5899 T18318 T18319 nummod 25,%
R5900 T18319 T18317 pobj %,in
R5901 T18320 T18321 punct –,%
R5902 T18321 T18319 prep %,%
R5903 T18322 T18321 nummod 50,%
R5904 T18323 T18319 prep of,%
R5905 T18324 T18323 pobj glomeruli,of
R5906 T18325 T18299 punct ;,hypercellularity
R5907 T18326 T18327 dep grade,hypercellularity
R5908 T18327 T18299 dep hypercellularity,hypercellularity
R5909 T18328 T18326 nummod 2,grade
R5910 T18329 T18327 punct ", ",hypercellularity
R5911 T18330 T18327 acl involving,hypercellularity
R5912 T18331 T18332 amod greater,50
R5913 T18332 T18334 nummod 50,%
R5914 T18333 T18332 quantmod than,50
R5915 T18334 T18330 dobj %,involving
R5916 T18335 T18334 prep of,%
R5917 T18336 T18337 det the,tuft
R5918 T18337 T18335 pobj tuft,of
R5919 T18338 T18337 amod glomerular,tuft
R5920 T18339 T18337 prep in,tuft
R5921 T18340 T18341 nummod 50,%
R5922 T18341 T18339 pobj %,in
R5923 T18342 T18343 punct –,%
R5924 T18343 T18341 prep %,%
R5925 T18344 T18343 nummod 75,%
R5926 T18345 T18341 prep of,%
R5927 T18346 T18345 pobj glomeruli,of
R5928 T18347 T18299 punct ;,hypercellularity
R5929 T18348 T18299 dep grade,hypercellularity
R5930 T18349 T18348 nummod 3,grade
R5931 T18350 T18299 punct ", ",hypercellularity
R5932 T18351 T18299 amod glomerular,hypercellularity
R5933 T18352 T18299 prep in,hypercellularity
R5934 T18353 T18354 amod greater,75
R5935 T18354 T18356 nummod 75,%
R5936 T18355 T18354 quantmod than,75
R5937 T18356 T18352 pobj %,in
R5938 T18357 T18356 prep of,%
R5939 T18358 T18357 pobj glomeruli,of
R5940 T18359 T18358 cc or,glomeruli
R5941 T18360 T18358 conj crescents,glomeruli
R5942 T18361 T18299 prep in,hypercellularity
R5943 T18362 T18363 amod greater,25
R5944 T18363 T18365 nummod 25,%
R5945 T18364 T18363 quantmod than,25
R5946 T18365 T18361 pobj %,in
R5947 T18366 T18365 prep of,%
R5948 T18367 T18366 pobj glomeruli,of
R5949 T18368 T18289 punct .,graded
R5950 T18540 T18541 amod Statistical,analysis
R5951 T18543 T18544 amod Non-parametric,data
R5952 T18544 T18545 nsubjpass data,expressed
R5953 T18546 T18545 auxpass are,expressed
R5954 T18547 T18545 prep as,expressed
R5955 T18548 T18547 pobj median,as
R5956 T18549 T18550 mark with,range
R5957 T18550 T18545 advcl range,expressed
R5958 T18551 T18550 prep of,range
R5959 T18552 T18551 pobj values,of
R5960 T18553 T18550 prep in,range
R5961 T18554 T18553 pobj parentheses,in
R5962 T18555 T18545 punct .,expressed
R5963 T18557 T18558 det All,statistics
R5964 T18558 T18559 nsubjpass statistics,calculated
R5965 T18560 T18559 auxpass were,calculated
R5966 T18561 T18559 advcl using,calculated
R5967 T18562 T18563 compound GraphPad,PrismTM
R5968 T18563 T18561 dobj PrismTM,using
R5969 T18564 T18563 npadvmod version,PrismTM
R5970 T18565 T18564 nummod 3.0,version
R5971 T18566 T18563 prep for,PrismTM
R5972 T18567 T18566 pobj Windows,for
R5973 T18568 T18569 punct (,Software
R5974 T18569 T18563 parataxis Software,PrismTM
R5975 T18570 T18569 compound GraphPad,Software
R5976 T18571 T18569 punct ", ",Software
R5977 T18572 T18573 compound San,Diego
R5978 T18573 T18569 npadvmod Diego,Software
R5979 T18574 T18569 punct ", ",Software
R5980 T18575 T18569 npadvmod California,Software
R5981 T18576 T18569 punct ", ",Software
R5982 T18577 T18578 compound United,States
R5983 T18578 T18569 npadvmod States,Software
R5984 T18579 T18569 punct ),Software
R5985 T18580 T18559 punct .,calculated
R5986 T18582 T18583 amod Non-parametric,tests
R5987 T18583 T18584 nsubjpass tests,applied
R5988 T18585 T18584 auxpass were,applied
R5989 T18586 T18584 advmod throughout,applied
R5990 T18587 T18584 punct ", ",applied
R5991 T18588 T18584 prep with,applied
R5992 T18589 T18590 nsubjpass differences,considered
R5993 T18590 T18588 pcomp considered,with
R5994 T18591 T18590 auxpass being,considered
R5995 T18592 T18590 oprd significant,considered
R5996 T18593 T18592 prep for,significant
R5997 T18594 T18595 compound p,values
R5998 T18595 T18593 pobj values,for
R5999 T18596 T18597 punct <,0.05
R6000 T18597 T18595 amod 0.05,values
R6001 T18598 T18584 punct .,applied
R6002 T18600 T18601 det The,test
R6003 T18601 T18605 nsubjpass test,used
R6004 T18602 T18603 compound Mann,Whitney
R6005 T18603 T18601 compound Whitney,test
R6006 T18604 T18603 punct –,Whitney
R6007 T18606 T18605 auxpass was,used
R6008 T18607 T18605 prep for,used
R6009 T18608 T18607 pobj comparison,for
R6010 T18609 T18608 prep of,comparison
R6011 T18610 T18611 nummod two,groups
R6012 T18611 T18609 pobj groups,of
R6013 T18612 T18605 punct ", ",used
R6014 T18613 T18614 mark whilst,used
R6015 T18614 T18605 advcl used,used
R6016 T18615 T18614 prep for,used
R6017 T18616 T18615 pobj analysis,for
R6018 T18617 T18616 prep of,analysis
R6019 T18618 T18619 nummod three,groups
R6020 T18619 T18617 pobj groups,of
R6021 T18620 T18621 det the,test
R6022 T18621 T18614 nsubjpass test,used
R6023 T18622 T18623 compound Kruskal,Wallis
R6024 T18623 T18621 compound Wallis,test
R6025 T18624 T18623 punct –,Wallis
R6026 T18625 T18621 prep with,test
R6027 T18626 T18627 poss Dunn,test
R6028 T18627 T18625 pobj test,with
R6029 T18628 T18626 case 's,Dunn
R6030 T18629 T18630 amod multiple,comparison
R6031 T18630 T18627 compound comparison,test
R6032 T18631 T18614 auxpass was,used
R6033 T18632 T18605 punct .,used
R6034 T18821 T18822 amod Genotypic,analysis
R6035 T18824 T18825 nsubjpass Genotyping,carried
R6036 T18826 T18825 auxpass was,carried
R6037 T18827 T18825 prt out,carried
R6038 T18828 T18825 prep by,carried
R6039 T18829 T18828 pobj PCR,by
R6040 T18830 T18829 prep of,PCR
R6041 T18831 T18832 amod genomic,DNA
R6042 T18832 T18830 pobj DNA,of
R6043 T18833 T18825 advcl using,carried
R6044 T18834 T18835 nummod 143,markers
R6045 T18835 T18833 dobj markers,using
R6046 T18836 T18835 amod polymorphic,markers
R6047 T18837 T18838 punct (,available
R6048 T18838 T18835 parataxis available,markers
R6049 T18839 T18838 nsubj list,available
R6050 T18840 T18838 prep on,available
R6051 T18841 T18840 pobj request,on
R6052 T18842 T18838 punct ),available
R6053 T18843 T18835 acl distributed,markers
R6054 T18844 T18843 prep throughout,distributed
R6055 T18845 T18846 det all,autosomes
R6056 T18846 T18844 pobj autosomes,throughout
R6057 T18847 T18846 nummod 19,autosomes
R6058 T18848 T18825 punct .,carried
R6059 T18850 T18851 nsubjpass PCRs,performed
R6060 T18852 T18851 auxpass were,performed
R6061 T18853 T18851 advcl using,performed
R6062 T18854 T18855 amod standard,reagents
R6063 T18855 T18853 dobj reagents,using
R6064 T18856 T18855 acl containing,reagents
R6065 T18857 T18858 nummod 1.5,mM
R6066 T18858 T18859 compound mM,MgCl2
R6067 T18859 T18856 dobj MgCl2,containing
R6068 T18860 T18859 cc and,MgCl2
R6069 T18861 T18862 nummod 0.4,μM
R6070 T18862 T18863 compound μM,primers
R6071 T18863 T18859 conj primers,MgCl2
R6072 T18864 T18851 punct .,performed
R6073 T18866 T18867 compound Microsatellite,markers
R6074 T18867 T18868 nsubjpass markers,screened
R6075 T18869 T18868 auxpass were,screened
R6076 T18870 T18868 prep for,screened
R6077 T18871 T18872 compound size,polymorphisms
R6078 T18872 T18870 pobj polymorphisms,for
R6079 T18873 T18872 prep between,polymorphisms
R6080 T18874 T18875 nummod 129,mice
R6081 T18875 T18873 pobj mice,between
R6082 T18876 T18874 cc and,129
R6083 T18877 T18874 conj C57BL,129
R6084 T18878 T18877 punct /,C57BL
R6085 T18879 T18877 nummod 6,C57BL
R6086 T18880 T18868 punct .,screened
R6087 T18882 T18883 advmod Only,primers
R6088 T18883 T18884 nsubjpass primers,used
R6089 T18885 T18883 prep with,primers
R6090 T18886 T18885 pobj differences,with
R6091 T18887 T18886 amod detectable,differences
R6092 T18888 T18887 prep on,detectable
R6093 T18889 T18890 compound ethidium,bromide
R6094 T18890 T18891 npadvmod bromide,stained
R6095 T18891 T18893 amod stained,gels
R6096 T18892 T18891 punct -,stained
R6097 T18893 T18888 pobj gels,on
R6098 T18894 T18893 compound agarose,gels
R6099 T18895 T18888 cc or,on
R6100 T18896 T18888 conj on,on
R6101 T18897 T18898 compound SDS,polyacrylamide
R6102 T18898 T18900 compound polyacrylamide,gels
R6103 T18899 T18898 punct -,polyacrylamide
R6104 T18900 T18896 pobj gels,on
R6105 T18901 T18884 auxpass were,used
R6106 T18902 T18884 punct .,used
R6107 T19159 T19160 compound Linkage,analysis
R6108 T19162 T19163 det The,program
R6109 T19163 T19165 nsubjpass program,used
R6110 T19164 T19163 compound QTL,program
R6111 T19166 T19163 appos MAPMANAGER.QTL,program
R6112 T19167 T19168 punct (,ftp://mcbio.med.buffalo.edu/pub/MapMgr/
R6113 T19168 T19163 parataxis ftp://mcbio.med.buffalo.edu/pub/MapMgr/,program
R6114 T19169 T19168 punct ),ftp://mcbio.med.buffalo.edu/pub/MapMgr/
R6115 T19170 T19165 auxpass was,used
R6116 T19171 T19165 punct ", ",used
R6117 T19172 T19165 cc and,used
R6118 T19173 T19174 det the,groups
R6119 T19174 T19177 nsubjpass groups,examined
R6120 T19175 T19174 nummod two,groups
R6121 T19176 T19174 amod experimental,groups
R6122 T19177 T19165 conj examined,used
R6123 T19178 T19177 auxpass were,examined
R6124 T19179 T19177 advmod independently,examined
R6125 T19180 T19177 punct .,examined
R6126 T19182 T19183 advmod Only,data
R6127 T19183 T19184 nsubjpass data,analysed
R6128 T19185 T19183 prep from,data
R6129 T19186 T19185 pobj mice,from
R6130 T19187 T19186 prep at,mice
R6131 T19188 T19189 nummod 12,mo
R6132 T19189 T19187 pobj mo,at
R6133 T19190 T19189 prep of,mo
R6134 T19191 T19190 pobj age,of
R6135 T19192 T19184 auxpass were,analysed
R6136 T19193 T19184 punct .,analysed
R6137 T19195 T19196 compound Log,transformations
R6138 T19196 T19197 nsubj transformations,resulted
R6139 T19198 T19196 prep of,transformations
R6140 T19199 T19200 compound auto-Abs,levels
R6141 T19200 T19198 pobj levels,of
R6142 T19201 T19197 prep in,resulted
R6143 T19202 T19203 advmod more,normalised
R6144 T19203 T19204 amod normalised,distribution
R6145 T19204 T19201 pobj distribution,in
R6146 T19205 T19197 cc and,resulted
R6147 T19206 T19207 auxpass were,used
R6148 T19207 T19197 conj used,resulted
R6149 T19208 T19207 prep in,used
R6150 T19209 T19210 compound QTL,mapping
R6151 T19210 T19208 pobj mapping,in
R6152 T19211 T19197 punct .,resulted
R6153 T19213 T19214 compound LOD,thresholds
R6154 T19214 T19215 nsubjpass thresholds,determined
R6155 T19216 T19214 prep for,thresholds
R6156 T19217 T19218 amod suggestive,linkages
R6157 T19218 T19216 pobj linkages,for
R6158 T19219 T19217 cc and,suggestive
R6159 T19220 T19217 conj significant,suggestive
R6160 T19221 T19215 auxpass were,determined
R6161 T19222 T19215 prep by,determined
R6162 T19223 T19222 pcomp using,by
R6163 T19224 T19225 det a,test
R6164 T19225 T19223 dobj test,using
R6165 T19226 T19227 npadvmod cohort,specific
R6166 T19227 T19225 amod specific,test
R6167 T19228 T19226 punct -,cohort
R6168 T19229 T19226 cc and,cohort
R6169 T19230 T19226 conj trait,cohort
R6170 T19231 T19230 punct -,trait
R6171 T19232 T19225 compound permutation,test
R6172 T19233 T19234 punct (,permutations
R6173 T19234 T19225 parataxis permutations,test
R6174 T19235 T19234 nummod "1,000",permutations
R6175 T19236 T19234 punct ),permutations
R6176 T19237 T19215 punct .,determined
R6177 T19239 T19240 det The,threshold
R6178 T19240 T19242 nsubj threshold,were
R6179 T19241 T19240 amod average,threshold
R6180 T19243 T19240 prep for,threshold
R6181 T19244 T19245 amod suggestive,linkages
R6182 T19245 T19243 pobj linkages,for
R6183 T19246 T19244 punct ", ",suggestive
R6184 T19247 T19244 conj significant,suggestive
R6185 T19248 T19247 punct ", ",significant
R6186 T19249 T19247 cc and,significant
R6187 T19250 T19251 advmod highly,significant
R6188 T19251 T19247 conj significant,significant
R6189 T19252 T19242 attr LOD,were
R6190 T19253 T19254 punct ≥,2.1
R6191 T19254 T19252 amod 2.1,LOD
R6192 T19255 T19256 punct (,3
R6193 T19256 T19252 parataxis 3,LOD
R6194 T19257 T19256 nsubj p,3
R6195 T19258 T19256 punct ≤,3
R6196 T19259 T19256 quantmod 7.8,3
R6197 T19260 T19256 punct ×,3
R6198 T19261 T19256 quantmod 10,3
R6199 T19262 T19256 punct −,3
R6200 T19263 T19256 punct ),3
R6201 T19264 T19252 punct ", ",LOD
R6202 T19265 T19252 conj LOD,LOD
R6203 T19266 T19267 punct ≥,3.6
R6204 T19267 T19265 amod 3.6,LOD
R6205 T19268 T19269 punct (,4
R6206 T19269 T19265 parataxis 4,LOD
R6207 T19270 T19269 nsubj p,4
R6208 T19271 T19269 punct ≤,4
R6209 T19272 T19269 quantmod 2.4,4
R6210 T19273 T19269 punct ×,4
R6211 T19274 T19269 quantmod 10,4
R6212 T19275 T19269 punct −,4
R6213 T19276 T19269 punct ),4
R6214 T19277 T19265 punct ", ",LOD
R6215 T19278 T19265 cc and,LOD
R6216 T19279 T19265 conj LOD,LOD
R6217 T19280 T19281 punct ≥,5
R6218 T19281 T19279 amod 5,LOD
R6219 T19282 T19283 punct (,5
R6220 T19283 T19279 parataxis 5,LOD
R6221 T19284 T19283 nsubj p,5
R6222 T19285 T19283 punct ≤,5
R6223 T19286 T19283 quantmod 1,5
R6224 T19287 T19283 punct ×,5
R6225 T19288 T19283 quantmod 10,5
R6226 T19289 T19283 punct −,5
R6227 T19290 T19283 punct ),5
R6228 T19291 T19242 punct ", ",were
R6229 T19292 T19242 advmod respectively,were
R6230 T19293 T19294 punct (,Manly
R6231 T19294 T19242 meta Manly,were
R6232 T19295 T19294 cc and,Manly
R6233 T19296 T19294 conj Olson,Manly
R6234 T19297 T19296 nummod 1999,Olson
R6235 T19298 T19296 punct ),Olson
R6236 T19299 T19242 punct .,were
R4179 T14772 T14770 conj Butler,Pepys
R4430 T15035 T15036 det these,auto-Abs
R4433 T15038 T14990 punct .,failed
R4434 T15040 T15041 det These,findings
R4435 T15041 T15042 nsubj findings,indicated
R4601 T15218 T15219 mark that,reported
R4778 T15403 T15400 prep with,comparing
R4779 T15404 T15405 det the,Apcs
R4780 T15405 T15403 pobj Apcs,with
R17 T572 T574 amod Targeted,Mice
R21 T579 T581 nsubj erythematosus,is
R37 T596 T590 dobj role,play
R44 T605 T607 amod targeted,mice
R55 T616 T614 dobj genes,implicating
R82 T645 T647 amod targeted,mice
R92 T657 T654 nsubj background,influences
R96 T661 T654 dobj phenotype,influences
R102 T667 T669 amod targeted,mice
R108 T675 T673 dobj role,suggests
R117 T684 T686 advmod yet,uncharacterised
R119 T686 T688 amod uncharacterised,genes
R121 T688 T682 pobj genes,of
R132 T701 T703 amod wide,analysis
R134 T703 T698 dobj analysis,Using
R139 T708 T699 dobj loci,identified
R208 T779 T777 pobj gene,to
R214 T787 T785 dobj modifiers,demonstrate
R247 T822 T820 pobj traits,of
R1261 T4478 T4470 conj F2,F2
R2072 T7270 T7271 punct (,Pepys
R2193 T7399 T7396 prep between,region
R552 T3115 T3116 det these,loci
R911 T3490 T3491 aux to,develop
R912 T3491 T3489 xcomp develop,reported
R3192 T13733 T13711 meta Bickerstaff,is
R3372 T13923 T13921 nummod 6,C57BL
R3373 T13924 T13921 punct ", ",C57BL
R3472 T14029 T14030 npadvmod gene,targeted
R3731 T14302 T14303 amod multiple,loci
R4076 T14664 T14658 nmod et,Drake
R4077 T14665 T14658 nmod al.,Drake

2_test

Id Subject Object Predicate Lexical cue
15314659-8616887-84764671 2085-2089 8616887 denotes 1996
15314659-9914226-84764672 2105-2109 9914226 denotes 1998
15314659-10354363-84764673 2135-2139 10354363 denotes 1999
15314659-11567630-84764674 2157-2161 11567630 denotes 2001
15314659-3890479-84764675 2934-2938 3890479 denotes 1985
15314659-10354363-84764676 3709-3713 10354363 denotes 1999
15314659-11567630-84764677 3731-3735 11567630 denotes 2001
15314659-228283-84764678 4633-4637 228283 denotes 1979
15314659-9590289-84764679 4652-4656 9590289 denotes 1998
15314659-10371509-84764680 4677-4681 10371509 denotes 1999
15314659-11564828-84764681 4705-4709 11564828 denotes 2001
15314659-10981970-84764682 4836-4840 10981970 denotes 2000
15314659-11564828-84764683 4864-4868 11564828 denotes 2001
15314659-11859149-84764684 4886-4890 11859149 denotes 2002
15314659-10371509-84764685 5658-5662 10371509 denotes 1999
15314659-11172029-84764686 5892-5896 11172029 denotes 2001
15314659-7868910-84764687 5918-5922 7868910 denotes 1995
15314659-9164982-84764688 5936-5940 9164982 denotes 1997
15314659-9743333-84764689 5968-5972 9743333 denotes 1998
15314659-10693874-84764690 5989-5993 10693874 denotes 2000
15314659-9846493-84764691 6237-6241 9846493 denotes 1998
15314659-10981970-84764692 6263-6267 10981970 denotes 2000
15314659-12213736-84764693 6281-6285 12213736 denotes 2002
15314659-12133988-84764694 6297-6301 12133988 denotes 2002
15314659-9590289-84764695 7803-7807 9590289 denotes 1998
15314659-10371509-84764696 8075-8079 10371509 denotes 1999
15314659-423976-84764697 14709-14713 423976 denotes 1979
15314659-7389204-84764698 14728-14732 7389204 denotes 1980
15314659-8662234-84764699 15066-15070 8662234 denotes 1996
15314659-8013918-84764700 16837-16841 8013918 denotes 1994
15314659-10371509-84764701 19910-19914 10371509 denotes 1999
15314659-10371509-84764702 22829-22833 10371509 denotes 1999
15314659-10981970-84764703 23110-23114 10981970 denotes 2000
15314659-12213736-84764704 23128-23132 12213736 denotes 2002
15314659-12133988-84764705 23144-23148 12133988 denotes 2002
15314659-6609979-84764706 23873-23877 6609979 denotes 1984
15314659-3260184-84764707 24028-24032 3260184 denotes 1988
15314659-2599002-84764708 24048-24052 2599002 denotes 1989
15314659-3260184-84764709 24158-24162 3260184 denotes 1988
15314659-10981970-84764710 24328-24332 10981970 denotes 2000
15314659-11564828-84764711 24356-24360 11564828 denotes 2001
15314659-11859149-84764712 24378-24382 11859149 denotes 2002
15314659-228283-84764713 25388-25392 228283 denotes 1979
15314659-9590289-84764714 25407-25411 9590289 denotes 1998
15314659-10371509-84764715 25432-25436 10371509 denotes 1999
15314659-11564828-84764716 25460-25464 11564828 denotes 2001
15314659-10485648-84764717 26558-26562 10485648 denotes 1999
15314659-10693874-84764718 26579-26583 10693874 denotes 2000
15314659-9862363-84764719 26758-26762 9862363 denotes 1998
15314659-10485648-84764720 26777-26781 10485648 denotes 1999
15314659-12215897-84764721 26794-26798 12215897 denotes 2002
15314659-11172029-84764722 27528-27532 11172029 denotes 2001
15314659-7868910-84764723 27554-27558 7868910 denotes 1995
15314659-8986781-84764724 27573-27577 8986781 denotes 1996
15314659-9164982-84764725 27591-27595 9164982 denotes 1997
15314659-9743333-84764726 27623-27627 9743333 denotes 1998
15314659-9843982-84764727 27829-27833 9843982 denotes 1998
15314659-4545894-84764728 28045-28049 4545894 denotes 1974
15314659-3675579-84764729 28068-28072 3675579 denotes 1987
15314659-2358775-84764730 28088-28092 2358775 denotes 1990
15314659-2455001-84764731 28168-28172 2455001 denotes 1988
15314659-2794863-84764732 28192-28196 2794863 denotes 1989
15314659-11441067-84764733 28214-28218 11441067 denotes 2001
15314659-10371509-84764734 28405-28409 10371509 denotes 1999
15314659-10981970-84764735 30548-30552 10981970 denotes 2000
15314659-9846493-84764736 30600-30604 9846493 denotes 1998
15314659-12133988-84764737 30616-30620 12133988 denotes 2002
15314659-12213736-84764738 30673-30677 12213736 denotes 2002
15314659-8864124-84764739 31194-31198 8864124 denotes 1996
15314659-10209047-84764740 31200-31204 10209047 denotes 1999
15314659-12794828-84764741 31999-32003 12794828 denotes 2003
15314659-14645206-84764742 32165-32169 14645206 denotes 2004
15314659-9256275-84764743 33503-33507 9256275 denotes 1997
15314659-11859149-84764744 35427-35431 11859149 denotes 2002
15314659-11859149-84764745 35652-35656 11859149 denotes 2002
15314659-10087288-84764746 38721-38725 10087288 denotes 1999
T51357 2085-2089 8616887 denotes 1996
T55221 2105-2109 9914226 denotes 1998
T49097 2135-2139 10354363 denotes 1999
T98221 2157-2161 11567630 denotes 2001
T25847 2934-2938 3890479 denotes 1985
T75279 3709-3713 10354363 denotes 1999
T22076 3731-3735 11567630 denotes 2001
T56429 4633-4637 228283 denotes 1979
T44236 4652-4656 9590289 denotes 1998
T39801 4677-4681 10371509 denotes 1999
T41469 4705-4709 11564828 denotes 2001
T37367 4836-4840 10981970 denotes 2000
T41479 4864-4868 11564828 denotes 2001
T64213 4886-4890 11859149 denotes 2002
T2630 5658-5662 10371509 denotes 1999
T752 5892-5896 11172029 denotes 2001
T11642 5918-5922 7868910 denotes 1995
T68448 5936-5940 9164982 denotes 1997
T45450 5968-5972 9743333 denotes 1998
T26221 5989-5993 10693874 denotes 2000
T99718 6237-6241 9846493 denotes 1998
T34861 6263-6267 10981970 denotes 2000
T88346 6281-6285 12213736 denotes 2002
T95921 6297-6301 12133988 denotes 2002
T79019 7803-7807 9590289 denotes 1998
T95196 8075-8079 10371509 denotes 1999
T88647 14709-14713 423976 denotes 1979
T91165 14728-14732 7389204 denotes 1980
T82964 15066-15070 8662234 denotes 1996
T36122 16837-16841 8013918 denotes 1994
T27344 19910-19914 10371509 denotes 1999
T67827 22829-22833 10371509 denotes 1999
T47165 23110-23114 10981970 denotes 2000
T34317 23128-23132 12213736 denotes 2002
T17512 23144-23148 12133988 denotes 2002
T31912 23873-23877 6609979 denotes 1984
T4747 24028-24032 3260184 denotes 1988
T25272 24048-24052 2599002 denotes 1989
T35333 24158-24162 3260184 denotes 1988
T5249 24328-24332 10981970 denotes 2000
T80624 24356-24360 11564828 denotes 2001
T7856 24378-24382 11859149 denotes 2002
T41952 25388-25392 228283 denotes 1979
T63291 25407-25411 9590289 denotes 1998
T25457 25432-25436 10371509 denotes 1999
T44708 25460-25464 11564828 denotes 2001
T2371 26558-26562 10485648 denotes 1999
T4613 26579-26583 10693874 denotes 2000
T5848 26758-26762 9862363 denotes 1998
T27684 26777-26781 10485648 denotes 1999
T82375 26794-26798 12215897 denotes 2002
T54172 27528-27532 11172029 denotes 2001
T45771 27554-27558 7868910 denotes 1995
T66469 27573-27577 8986781 denotes 1996
T3269 27591-27595 9164982 denotes 1997
T13701 27623-27627 9743333 denotes 1998
T8055 27829-27833 9843982 denotes 1998
T47135 28045-28049 4545894 denotes 1974
T76573 28068-28072 3675579 denotes 1987
T34207 28088-28092 2358775 denotes 1990
T85985 28168-28172 2455001 denotes 1988
T30710 28192-28196 2794863 denotes 1989
T59226 28214-28218 11441067 denotes 2001
T92885 28405-28409 10371509 denotes 1999
T68658 30548-30552 10981970 denotes 2000
T27069 30600-30604 9846493 denotes 1998
T68023 30616-30620 12133988 denotes 2002
T24115 30673-30677 12213736 denotes 2002
T51797 31194-31198 8864124 denotes 1996
T70888 31200-31204 10209047 denotes 1999
T24476 31999-32003 12794828 denotes 2003
T82272 32165-32169 14645206 denotes 2004
T51496 33503-33507 9256275 denotes 1997
T85978 35427-35431 11859149 denotes 2002
T33622 35652-35656 11859149 denotes 2002
T2074 38721-38725 10087288 denotes 1999

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T18812 37835-37849 SO_EXT:microsatellite_unit_or_region denotes Microsatellite
T18810 37809-37814 CHEBI:6636 denotes MgCl2
T18809 37782-37790 CHEBI_EXT:33893 denotes reagents
T18808 37736-37745 GO:0030849 denotes autosomes
T18807 37670-37677 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T18806 37658-37669 SO_EXT:polymorphism denotes polymorphic
T18805 37644-37647 CHEBI_SO_EXT:DNA denotes DNA
T18804 37636-37647 SO_EXT:genomic_DNA denotes genomic DNA
T18803 37580-37589 SO_EXT:genotype_or_entity_with_genotype denotes Genotypic
T18233 37047-37056 UBERON:0000074 denotes glomeruli
T18232 37001-37010 UBERON:0000074 denotes glomeruli
T17683 36045-36049 PR_EXT:000004126 denotes Apcs
T17682 36039-36044 NCBITaxon:10088 denotes mouse
T17681 36028-36033 NCBITaxon:9940 denotes sheep
T17680 35987-35991 PR_EXT:000004126 denotes Apcs
T17679 35945-35950 UBERON:0001977 denotes serum
T17678 35836-35841 NCBITaxon:10088 denotes mouse
T17677 35577-35586 GO:0000785 denotes chromatin
T17676 35562-35567 CHEBI_SO_EXT:single_stranded_DNA denotes ssDNA
T17675 35555-35558 GO:0042571 denotes Abs
T17674 35492-35497 CHEBI_SO_EXT:double_stranded_DNA denotes dsDNA
T17673 35434-35439 UBERON:0001977 denotes Serum
T17672 35367-35385 NCBITaxon:46909 denotes Crithidia luciliae
T17671 35315-35318 GO:0042571 denotes Abs
T17670 35309-35314 CHEBI_SO_EXT:double_stranded_DNA denotes dsDNA
T17669 35293-35298 CL_GO_EXT:cell denotes cells
T17668 35230-35233 GO:0071735 denotes IgG
T17667 35215-35218 GO:0042571 denotes Abs
T17666 35138-35142 UBERON:0001977 denotes Sera
T17665 35116-35127 CHMO_UBERON_EXT:bodily_fluid_or_bodily_fluid_experimental_method denotes Serological
T16668 35047-35053 NCBITaxon:33208 denotes animal
T16667 34981-34988 NCBITaxon:33208 denotes Animals
T16666 34948-34949 SO_EXT:sequence_nullness_or_absence denotes −
T16665 34946-34947 SO_EXT:sequence_nullness_or_absence denotes −
T16664 34941-34945 NCBITaxon:10088 denotes mice
T16663 34934-34940 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T16662 34896-34903 NCBITaxon:33208 denotes animals
T16661 34886-34895 SO_EXT:wild_type_entity_or_quality denotes wild-type
T16660 34866-34870 NCBITaxon:10088 denotes mice
T16659 34865-34866 SO_EXT:sequence_nullness_or_absence denotes −
T16658 34863-34864 SO_EXT:sequence_nullness_or_absence denotes −
T16657 34858-34862 PR_EXT:000004126 denotes Apcs
T16656 34773-34780 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T16655 34684-34691 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T16654 34572-34576 PR_EXT:000004126 denotes Apcs
T16653 34554-34560 SO_EXT:0001026 denotes genome
T16652 34493-34497 NCBITaxon:10088 denotes mice
T16651 34491-34492 SO_EXT:sequence_nullness_or_absence denotes −
T16650 34489-34490 SO_EXT:sequence_nullness_or_absence denotes −
T16649 34484-34488 PR_EXT:000004126 denotes Apcs
T16648 34390-34396 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T16647 34291-34298 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T16646 34270-34278 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes interval
T16645 34257-34267 _FRAGMENT denotes Chromosome
T16644 34229-34233 NCBITaxon:10088 denotes mice
T16643 34096-34100 NCBITaxon:10088 denotes mice
T16642 34060-34071 SO_EXT:polymorphism denotes polymorphic
T16641 34052-34059 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T16640 34037-34051 SO_EXT:microsatellite_unit_or_region denotes microsatellite
T16639 33917-33932 SO_EXT:microsatellite_unit_or_region denotes microsatellites
T16638 33856-33860 NCBITaxon:10088 denotes mice
T16637 33811-33820 SO_EXT:wild_type_entity_or_quality denotes Wild-type
T16636 33769-33773 NCBITaxon:10088 denotes mice
T16635 33762-33768 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T16634 33760-33761 SO_EXT:sequence_nullness_or_absence denotes −
T16633 33758-33759 SO_EXT:sequence_nullness_or_absence denotes −
T16632 33753-33757 PR_EXT:000004126 denotes Apcs
T16631 33640-33647 NCBITaxon:33208 denotes animals
T16630 33638-33639 SO_EXT:sequence_nullness_or_absence denotes −
T16629 33636-33637 SO_EXT:sequence_nullness_or_absence denotes −
T16628 33631-33635 PR_EXT:000004126 denotes Apcs
T16627 33607-33614 SO_EXT:0000704 denotes genetic
T16626 33591-33595 NCBITaxon:10088 denotes mice
T16625 33589-33590 SO_EXT:sequence_nullness_or_absence denotes −
T16624 33587-33588 SO_EXT:sequence_nullness_or_absence denotes −
T16623 33582-33586 PR_EXT:000004126 denotes Apcs
T16622 33545-33549 NCBITaxon:10088 denotes mice
T16621 33543-33544 SO_EXT:sequence_nullness_or_absence denotes −
T16620 33541-33542 SO_EXT:sequence_nullness_or_absence denotes −
T16619 33536-33540 PR_EXT:000004126 denotes Apcs
T16618 33446-33450 NCBITaxon:10088 denotes mice
T16617 33445-33446 SO_EXT:sequence_nullness_or_absence denotes −
T16616 33443-33444 SO_EXT:sequence_nullness_or_absence denotes −
T16615 33438-33442 PR_EXT:000004126 denotes Apcs
T16614 33428-33432 NCBITaxon:10088 denotes mice
T16613 33397-33405 GO_EXT:breeding denotes breeding
T16612 33384-33388 NCBITaxon:10088 denotes mice
T16611 33344-33353 SO_EXT:wild_type_entity_or_quality denotes wild-type
T16610 33299-33303 NCBITaxon:10088 denotes mice
T16609 33215-33221 NCBITaxon:33208 denotes animal
T16608 33188-33192 GO_EXT:breeding denotes bred
T16607 33107-33116 SO_EXT:wild_type_entity_or_quality denotes Wild-type
T16606 33098-33105 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T16605 33088-33092 NCBITaxon:10088 denotes mice
T16604 33074-33078 NCBITaxon:10088 denotes Mice
T13535 32030-32042 SO_EXT:polymorphism denotes polymorphism
T13534 31971-31983 UBERON:0001225 denotes renal cortex
T13533 31954-31963 GO:0032991 denotes complexes
T13532 31947-31953 UBERON:0002405 denotes immune
T13531 31823-31827 PR_EXT:000004126 denotes Apcs
T13530 31796-31803 CHEBI_PR_EXT:protein denotes protein
T13529 31784-31795 GO:0006953 denotes acute-phase
T13528 31772-31779 CHEBI_PR_EXT:protein denotes protein
T13527 31761-31779 PR_EXT:000005897 denotes C-reactive protein
T13526 31755-31760 NCBITaxon:9606 denotes human
T13525 31737-31747 GO:0010467 denotes expression
T13524 31642-31646 PR_EXT:000004126 denotes Apcs
T13523 31576-31584 GO:0019882 denotes antigens
T13522 31558-31571 _FRAGMENT denotes processing of
T13521 31528-31532 PR_EXT:000004126 denotes Apcs
T13520 31481-31485 NCBITaxon:10088 denotes mice
T13519 31449-31453 NCBITaxon:10088 denotes mice
T13518 31447-31448 SO_EXT:sequence_nullness_or_absence denotes −
T13517 31445-31446 SO_EXT:sequence_nullness_or_absence denotes −
T13516 31441-31445 PR_EXT:000004126 denotes Apcs
T13515 31358-31362 NCBITaxon:10088 denotes mice
T13514 31305-31309 NCBITaxon:10088 denotes mice
T13513 31303-31304 SO_EXT:sequence_nullness_or_absence denotes −
T13512 31301-31302 SO_EXT:sequence_nullness_or_absence denotes −
T13511 31297-31301 PR_EXT:000004126 denotes Apcs
T13510 31230-31237 GO:0005634 denotes nuclear
T13509 31165-31175 GO_SO_EXT:chromosome denotes Chromosome
T13508 31155-31161 SO_EXT:0001023 denotes allele
T13507 31108-31113 SO_EXT:0000704 denotes genes
T13506 31095-31104 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T13505 31078-31085 NCBITaxon:33208 denotes animals
T13504 31064-31068 SO_EXT:0000704 denotes gene
T13503 31003-31007 SO_EXT:0000704 denotes gene
T13502 30998-31002 SO_EXT:sequence_nullness denotes null
T13501 30948-30954 NCBITaxon:39107 denotes murine
T13500 30857-30864 SO_EXT:0000704 denotes genetic
T13499 30804-30809 CL_GO_EXT:cell denotes cells
T13498 30789-30809 CL:0002322 denotes embryonic stem cells
T13497 30789-30798 UBERON:0000922 denotes embryonic
T13496 30759-30767 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T13495 30754-30758 SO_EXT:sequence_nullness denotes null
T13494 30736-30740 NCBITaxon:10088 denotes mice
T13493 30702-30708 UBERON:0002405 denotes immune
T13492 30654-30658 PR_EXT:000025662 denotes CD55
T13491 30627-30652 PR_EXT:000025662 denotes decay-accelerating factor
T13490 30577-30580 PR_EXT:000001337 denotes CR1
T13489 30555-30575 GO_EXT:0004875 denotes complement receptors
T13488 30519-30526 PR_EXT:000001479 denotes FcγRIIB
T13487 30506-30510 NCBITaxon:10088 denotes mice
T13486 30421-30428 SO_EXT:sequence_coding_function denotes encoded
T13485 30415-30420 SO_EXT:0000704 denotes genes
T13484 30402-30411 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T13483 30383-30387 NCBITaxon:10088 denotes mice
T13482 30323-30326 GO:0042571 denotes Abs
T13481 30323-30326 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Abs
T13480 30304-30317 _FRAGMENT denotes production of
T13479 30254-30272 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomal region
T13478 30233-30237 SO_EXT:0000704 denotes gene
T13477 30225-30232 SO_EXT:sequence_alteration_process denotes mutated
T13476 30155-30161 SO_EXT:0001026 denotes genome
T13475 30126-30137 GO_EXT:biological_movement_or_translocation_process denotes transferred
T13474 30107-30117 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes Chromosome
T13473 30088-30099 _FRAGMENT denotes interval on
T13472 30010-30014 SO_EXT:0000704 denotes gene
T13471 30005-30009 PR_EXT:000004126 denotes Apcs
T13470 29989-29996 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes segment
T13469 29976-29986 _FRAGMENT denotes Chromosome
T13468 29870-29875 SO_EXT:0000704 denotes genic
T13467 29852-29859 SO_EXT:0001023 denotes alleles
T13466 29684-29688 NCBITaxon:10088 denotes mice
T13465 29584-29591 SO_EXT:0001026 denotes genomic
T13464 29526-29556 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomeric region of Chromosome
T13463 29511-29516 SO_EXT:0000704 denotes genes
T13462 29499-29506 SO_EXT:sequence_alteration_process denotes altered
T13461 29451-29455 PR_EXT:000004126 denotes Apcs
T13460 29369-29372 GO:0042571 denotes Abs
T13459 29260-29271 SO_EXT:0000704 denotes genetically
T13458 29247-29257 GO_SO_EXT:chromosome denotes Chromosome
T13457 29238-29242 NCBITaxon:10088 denotes mice
T13456 29236-29237 SO_EXT:sequence_nullness_or_absence denotes −
T13455 29234-29235 SO_EXT:sequence_nullness_or_absence denotes −
T13454 29229-29233 PR_EXT:000004126 denotes Apcs
T13453 29128-29130 GO:0042571 denotes Ab
T13452 29118-29127 GO:0000785 denotes chromatin
T13451 29128-29130 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Ab
T13450 29090-29104 _FRAGMENT denotes development of
T13449 29047-29051 SO_EXT:0000704 denotes gene
T13448 29042-29046 PR_EXT:000004126 denotes Apcs
T13447 28984-28990 SO_EXT:0001026 denotes genome
T13446 28783-28787 NCBITaxon:10088 denotes mice
T13445 28781-28782 SO_EXT:sequence_nullness_or_absence denotes −
T13444 28779-28780 SO_EXT:sequence_nullness_or_absence denotes −
T13443 28774-28778 PR_EXT:000004126 denotes Apcs
T13442 28695-28699 NCBITaxon:10088 denotes mice
T13441 28693-28694 SO_EXT:sequence_nullness_or_absence denotes −
T13440 28691-28692 SO_EXT:sequence_nullness_or_absence denotes −
T13439 28686-28690 PR_EXT:000004126 denotes Apcs
T13438 28622-28624 GO:0042571 denotes Ab
T13437 28612-28621 GO:0000785 denotes chromatin
T13436 28506-28515 GO:0000785 denotes chromatin
T13435 28471-28475 PR_EXT:000004126 denotes Apcs
T13434 28358-28365 GO:0032991 denotes complex
T13433 28351-28357 UBERON:0002405 denotes immune
T13432 28279-28283 NCBITaxon:10088 denotes mice
T13431 28277-28278 SO_EXT:sequence_nullness_or_absence denotes −
T13430 28275-28276 SO_EXT:sequence_nullness_or_absence denotes −
T13429 28270-28274 PR_EXT:000004126 denotes Apcs
T13428 28138-28143 CL_GO_EXT:cell denotes cells
T13427 28128-28143 CL:0000445 denotes apoptotic cells
T13426 28128-28137 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T13425 28114-28123 GO:0000785 denotes chromatin
T13424 28004-28017 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T13423 27995-28000 CL_GO_EXT:cell denotes cells
T13422 27985-28000 CL:0000445 denotes apoptotic cells
T13421 27985-27994 GO_PATO_EXT:apoptotic_process_or_quality denotes apoptotic
T13420 27970-27979 GO:0000785 denotes chromatin
T13419 27965-27968 CHEBI_SO_EXT:DNA denotes DNA
T13418 27949-27954 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T13417 27929-27936 CHEBI:60425 denotes amyloid
T13416 27923-27948 PR_EXT:000004126 denotes serum amyloid P component
T13415 27923-27928 UBERON:0001977 denotes serum
T13414 27917-27922 NCBITaxon:9606 denotes human
T13413 27874-27879 SO_EXT:0000704 denotes genes
T13412 27845-27849 SO_EXT:0000704 denotes gene
T13411 27840-27844 PR_EXT:000004126 denotes Apcs
T13410 27805-27810 NCBITaxon:9606 denotes human
T13409 27745-27750 NCBITaxon:9606 denotes human
T13408 27751-27761 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes Chromosome
T13407 27735-27744 _FRAGMENT denotes region on
T13406 27718-27729 SO:0000858 denotes orthologous
T13405 27696-27701 NCBITaxon:10088 denotes mouse
T13404 27702-27712 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes Chromosome
T13403 27686-27695 _FRAGMENT denotes region of
T13402 27461-27468 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes segment
T13401 27438-27458 _FRAGMENT denotes telomeric Chromosome
T13400 27424-27430 SO_EXT:0001026 denotes genome
T13399 27418-27423 NCBITaxon:10088 denotes mouse
T13398 27399-27402 GO:0042611 denotes MHC
T13397 27291-27302 SO_EXT:0000704 denotes genetically
T13396 27278-27288 GO_SO_EXT:chromosome denotes Chromosome
T13395 27268-27272 NCBITaxon:10088 denotes mice
T13394 27266-27267 SO_EXT:sequence_nullness_or_absence denotes −
T13393 27264-27265 SO_EXT:sequence_nullness_or_absence denotes −
T13392 27259-27263 PR_EXT:000004126 denotes Apcs
T13391 27217-27224 NCBITaxon:33208 denotes animals
T13390 27203-27207 SO_EXT:0000704 denotes gene
T13389 27104-27108 NCBITaxon:10088 denotes mice
T13388 27058-27063 SO_EXT:0000704 denotes genes
T13387 27036-27041 NCBITaxon:10088 denotes mouse
T13386 26968-26974 SO_EXT:0001026 denotes genome
T13385 26904-26911 SO_EXT:0000704 denotes genetic
T13384 26720-26726 NCBITaxon:39107 denotes murine
T13383 26603-26623 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes region on Chromosome
T13382 26475-26496 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes portion of Chromosome
T13381 26403-26410 SO_EXT:0001023 denotes alleles
T13380 26352-26372 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes region on Chromosome
T13379 26250-26260 GO_SO_EXT:chromosome denotes Chromosome
T13378 26241-26246 SO_EXT:0000704 denotes genes
T13377 26184-26205 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes segment on Chromosome
T13376 26133-26138 SO_EXT:0000704 denotes genes
T13375 26083-26091 GO_EXT:reaction_or_response denotes response
T13374 26059-26067 CHEBI_EXT:59132 denotes antigens
T13373 26051-26058 GO:0005634 denotes nuclear
T13372 26039-26047 GO_EXT:reaction_or_response denotes response
T13371 26032-26038 UBERON:0002405 denotes immune
T13370 25952-25955 GO:0042571 denotes Abs
T13369 25933-25943 GO:0010467 denotes expression
T13368 25882-25903 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes segment of Chromosome
T13367 25841-25845 NCBITaxon:10088 denotes mice
T13366 25752-25759 SO_EXT:0000704 denotes genetic
T13365 25597-25604 SO_EXT:0001023 denotes alleles
T13364 25518-25522 NCBITaxon:10088 denotes mice
T13363 25176-25180 NCBITaxon:10088 denotes mice
T13362 25162-25166 SO_EXT:0000704 denotes gene
T13361 25140-25147 SO_EXT:0000704 denotes genetic
T13360 25049-25056 SO_EXT:0000704 denotes genetic
T13359 24804-24811 SO_EXT:0001023 denotes alleles
T13358 24611-24617 NCBITaxon:39107 denotes murine
T13357 24576-24582 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T13356 24561-24575 SO_EXT:microsatellite_unit_or_region denotes microsatellite
T13355 24479-24486 SO_EXT:0001023 denotes alleles
T13354 24302-24306 NCBITaxon:10088 denotes mice
T13353 24288-24292 SO_EXT:0000704 denotes gene
T13352 24208-24215 SO_EXT:0000704 denotes genetic
T13351 24128-24134 UBERON:0002405 denotes immune
T13350 24099-24103 SO_EXT:0000704 denotes gene
T13349 23988-23991 GO:0042571 denotes Abs
T13348 23988-23991 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Abs
T13347 23968-23982 _FRAGMENT denotes development of
T13346 23943-23948 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T13345 23919-23923 SO_EXT:0000704 denotes gene
T13344 23897-23907 GO_SO_EXT:chromosome denotes chromosome
T13343 23895-23907 GO:0000806 denotes Y-chromosome
T13342 23846-23859 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Ab production
T13341 23846-23848 GO:0042571 denotes Ab
T13340 23769-23773 SO_EXT:0000704 denotes gene
T13339 23654-23660 GO_EXT:fatality_or_lethality denotes lethal
T13338 23636-23649 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Ab production
T13337 23636-23638 GO:0042571 denotes Ab
T13336 23565-23569 SO_EXT:0000704 denotes gene
T13335 23535-23539 NCBITaxon:10088 denotes mice
T13334 23518-23523 SO_EXT:0000704 denotes genes
T13333 23422-23428 UBERON:0002405 denotes immune
T13332 23378-23383 SO_EXT:0000704 denotes genes
T13331 23344-23348 SO_EXT:0000704 denotes gene
T13330 23299-23308 GO:0010467 denotes expressed
T13329 23293-23298 SO_EXT:0000704 denotes genes
T13328 23267-23271 SO_EXT:0000704 denotes gene
T13327 23260-23266 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T13326 23246-23250 SO_EXT:0000704 denotes gene
T13325 23211-23218 GO:0005634 denotes nuclear
T13324 23070-23077 SO_EXT:0000704 denotes genetic
T13323 23031-23036 CL_GO_EXT:cell denotes cells
T13322 23016-23036 CL:0002322 denotes embryonic stem cells
T13321 23016-23025 UBERON:0000922 denotes embryonic
T13320 22994-22998 SO_EXT:0000704 denotes gene
T13554 33029-33036 SO_EXT:0000704 denotes genetic
T13553 33000-33006 UBERON:0002405 denotes immune
T13552 32926-32930 SO_EXT:0000704 denotes gene
T13551 32856-32863 SO_EXT:0001026 denotes genomes
T13550 32744-32749 UBERON:0002113 denotes renal
T13549 32716-32720 PR_EXT:000004126 denotes Apcs
T13548 32612-32617 SO_EXT:0000704 denotes genes
T13547 32551-32555 NCBITaxon:10088 denotes mice
T13546 32480-32485 UBERON:0000062 denotes organ
T13545 32439-32444 SO_EXT:0000704 denotes genes
T13544 32261-32282 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes regions on Chromosome
T13543 32218-32222 NCBITaxon:10088 denotes mice
T13542 32216-32217 SO_EXT:sequence_nullness_or_absence denotes −
T13541 32214-32215 SO_EXT:sequence_nullness_or_absence denotes −
T13540 32210-32214 PR_EXT:000004126 denotes Apcs
T13539 32197-32201 NCBITaxon:10088 denotes mice
T13538 32142-32148 NCBITaxon:9606 denotes humans
T13537 32093-32100 CHEBI_PR_EXT:protein denotes protein
T13536 32082-32100 PR_EXT:000005897 denotes C-reactive protein
T13319 22915-22921 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes region
T13318 22902-22912 _FRAGMENT denotes Chromosome
T13317 22876-22881 SO_EXT:0000704 denotes genes
T13316 22731-22738 GO:0005634 denotes nuclear
T13315 22601-22608 CHEBI:60425 denotes amyloid
T13314 22595-22620 PR_EXT:000004126 denotes serum amyloid P component
T13313 22595-22600 UBERON:0001977 denotes serum
T13312 22568-22572 SO_EXT:0000704 denotes gene
T13311 22563-22567 PR_EXT:000004126 denotes Apcs
T13310 22546-22550 NCBITaxon:10088 denotes mice
T13309 22495-22505 GO_SO_EXT:chromosome denotes Chromosome
T13308 22455-22462 GO:0005634 denotes nuclear
T13307 22407-22416 SO_EXT:wild_type_entity_or_quality denotes wild-type
T13306 22349-22359 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes Chromosome
T13305 22334-22344 _FRAGMENT denotes portion of
T13304 22311-22316 NCBITaxon:10088 denotes mouse
T13303 22271-22280 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T13302 22257-22261 SO_EXT:0000704 denotes gene
T13301 22226-22233 NCBITaxon:33208 denotes animals
T13300 22200-22206 UBERON:0002405 denotes immune
T13299 22147-22151 NCBITaxon:10088 denotes mice
T13298 22066-22070 SO_EXT:0000704 denotes gene
T13297 22035-22040 NCBITaxon:10088 denotes mouse
T13296 21916-21920 NCBITaxon:10088 denotes mice
T13295 21902-21906 SO_EXT:0000704 denotes gene
T13294 21848-21853 SO_EXT:0000704 denotes genes
T8757 20779-20784 UBERON:0002113 denotes renal
T8756 20733-20740 SO_EXT:0001023 denotes alleles
T8755 20679-20683 PR_EXT:000004126 denotes Apcs
T8754 20605-20606 SO_EXT:sequence_nullness_or_absence denotes −
T8753 20603-20604 SO_EXT:sequence_nullness_or_absence denotes −
T8752 20598-20602 PR_EXT:000004126 denotes Apcs
T8751 20518-20525 UBERON:0002113 denotes kidneys
T8750 20465-20476 CHMO_UBERON_EXT:bodily_fluid_or_bodily_fluid_experimental_method denotes serological
T8749 20415-20422 GO:0005634 denotes nuclear
T8748 20357-20362 SO_EXT:0000704 denotes genes
T8747 20324-20342 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes loci on Chromosome
T8746 20243-20247 SO_EXT:0000704 denotes gene
T8745 20238-20242 PR_EXT:000004126 denotes Apcs
T8744 20222-20230 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T8743 20217-20221 SO_EXT:sequence_nullness denotes null
T8742 20199-20203 NCBITaxon:10088 denotes mice
T8741 20114-20117 GO:0042571 denotes Abs
T8740 20084-20093 GO:0010467 denotes expressed
T8739 20071-20078 NCBITaxon:33208 denotes animals
T8738 20004-20013 SO_EXT:wild_type_entity_or_quality denotes wild-type
T8737 19986-19987 SO_EXT:sequence_nullness_or_absence denotes −
T8736 19984-19985 SO_EXT:sequence_nullness_or_absence denotes −
T8735 19979-19983 PR_EXT:000004126 denotes Apcs
T8734 19936-19939 GO:0042571 denotes Abs
T8733 19789-19794 UBERON:0002113 denotes renal
T8732 19767-19770 GO:0042571 denotes Abs
T8731 19746-19756 GO_EXT:killing denotes sacrificed
T8730 19733-19740 NCBITaxon:33208 denotes animals
T8729 19694-19698 NCBITaxon:10088 denotes mice
T8728 19692-19693 SO_EXT:sequence_nullness_or_absence denotes −
T8727 19690-19691 SO_EXT:sequence_nullness_or_absence denotes −
T8726 19685-19689 PR_EXT:000004126 denotes Apcs
T8725 19472-19476 PR_EXT:000004126 denotes Apcs
T8709 19179-19183 NCBITaxon:10088 denotes mice
T8708 19026-19032 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T8707 19011-19025 SO_EXT:microsatellite_unit_or_region denotes microsatellite
T8706 18992-18996 NCBITaxon:10088 denotes mice
T8705 18967-18975 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes interval
T8704 18954-18964 _FRAGMENT denotes Chromosome
T8703 18889-18896 SO_EXT:0001026 denotes genomic
T8702 18834-18844 GO_SO_EXT:chromosome denotes chromosome
T8701 18822-18829 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T8700 18751-18758 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T8699 18736-18750 SO_EXT:microsatellite_unit_or_region denotes microsatellite
T8698 18699-18707 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes interval
T8697 18686-18696 _FRAGMENT denotes Chromosome
T8696 18553-18560 SO_EXT:0000704 denotes genetic
T8695 18467-18472 SO_EXT:0000704 denotes genic
T8694 18417-18422 NCBITaxon:10088 denotes mouse
T8693 18371-18401 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomeric region of Chromosome
T8692 18266-18276 GO_SO_EXT:chromosome denotes Chromosome
T6694 14785-14798 SO_EXT:coding_sequence denotes coding region
T6693 14780-14784 PR_EXT:000004126 denotes Apcs
T6692 14748-14756 SO_EXT:biological_sequence denotes sequence
T6691 14680-14684 PR_EXT:000004126 denotes Apcs
T6690 14650-14656 NCBITaxon:39107 denotes murine
T6689 14470-14474 NCBITaxon:10088 denotes mice
T6688 14424-14428 PR_EXT:000004126 denotes Apcs
T6687 14383-14387 NCBITaxon:10088 denotes mice
T6686 14323-14325 GO:0042571 denotes Ab
T6685 14313-14322 GO:0000785 denotes chromatin
T6684 14323-14325 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Ab
T6683 14286-14299 _FRAGMENT denotes production of
T6682 14263-14267 PR_EXT:000004126 denotes Apcs
T6681 13974-13989 SO_EXT:microsatellite_unit_or_region denotes microsatellites
T6680 13943-13963 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes region of Chromosome
T6679 13887-13891 NCBITaxon:10088 denotes mice
T6678 13877-13886 SO_EXT:wild_type_entity_or_quality denotes wild-type
T6677 13854-13858 NCBITaxon:10088 denotes mice
T6676 13852-13853 SO_EXT:sequence_nullness_or_absence denotes −
T6675 13850-13851 SO_EXT:sequence_nullness_or_absence denotes −
T6674 13845-13849 PR_EXT:000004126 denotes Apcs
T6673 13811-13814 GO:0042571 denotes Abs
T6672 13761-13765 SO_EXT:0000704 denotes gene
T6671 13756-13760 PR_EXT:000004126 denotes Apcs
T6670 13748-13755 SO_EXT:sequence_alteration_process denotes mutated
T6669 13716-13720 SO_EXT:0000704 denotes gene
T6668 13711-13715 PR_EXT:000004126 denotes Apcs
T6667 13703-13710 SO_EXT:sequence_alteration_process denotes mutated
T6666 13651-13658 SO_EXT:0000704 denotes gene(s)
T6665 13629-13633 NCBITaxon:10088 denotes mice
T6664 13627-13628 SO_EXT:sequence_nullness_or_absence denotes −
T6663 13625-13626 SO_EXT:sequence_nullness_or_absence denotes −
T6662 13620-13624 PR_EXT:000004126 denotes Apcs
T6661 13601-13603 GO:0042571 denotes Ab
T6660 13591-13600 GO:0000785 denotes chromatin
T6659 12500-12505 NCBITaxon:10088 denotes mouse
T6658 12466-12473 SO_EXT:0000704 denotes genetic
T6657 12414-12436 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes segments on Chromosome
T6656 12375-12388 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Ab production
T6655 12375-12377 GO:0042571 denotes Ab
T6654 12369-12374 CHEBI_SO_EXT:single_stranded_DNA denotes ssDNA
T6653 12355-12360 CHEBI_SO_EXT:double_stranded_DNA denotes dsDNA
T6652 12344-12348 SO_EXT:0000704 denotes gene
T6651 12339-12343 PR_EXT:000004126 denotes Apcs
T6650 12229-12259 GO_SO_EXT:telomere_or_telomeric_region_or_telomeric_orientation denotes telomeric region of Chromosome
T6649 12165-12167 GO:0042571 denotes Ab
T6648 12155-12164 GO:0000785 denotes chromatin
T6647 12075-12080 NCBITaxon:10088 denotes mouse
T6646 12018-12025 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6645 12006-12017 CHMO_UBERON_EXT:bodily_fluid_or_bodily_fluid_experimental_method denotes serological
T6644 11956-11979 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes intervals on Chromosome
T6643 11923-11926 SO_EXT:0000771 denotes QTL
T6642 11895-11921 SO_EXT:0000771 denotes quantitative trait linkage
T6731 18200-18203 SO_EXT:0000771 denotes QTL
T6730 18148-18152 NCBITaxon:10088 denotes mice
T6729 18040-18044 NCBITaxon:10088 denotes mice
T6728 18038-18039 SO_EXT:sequence_nullness_or_absence denotes −
T6727 18036-18037 SO_EXT:sequence_nullness_or_absence denotes −
T6726 18031-18035 PR_EXT:000004126 denotes Apcs
T6725 18017-18026 SO_EXT:wild_type_entity_or_quality denotes wild-type
T6724 17876-17886 GO_SO_EXT:chromosome denotes Chromosome
T6723 17744-17754 GO_SO_EXT:chromosome denotes Chromosome
T6722 17736-17740 NCBITaxon:10088 denotes mice
T6721 17726-17735 SO_EXT:wild_type_entity_or_quality denotes wild-type
T6720 17640-17643 SO_EXT:0000771 denotes QTL
T6719 17627-17634 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6718 17615-17626 CHMO_UBERON_EXT:bodily_fluid_or_bodily_fluid_experimental_method denotes serological
T6717 16940-16959 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes locus on Chromosome
T6716 16793-16803 GO_SO_EXT:chromosome denotes Chromosome
T6715 16727-16731 NCBITaxon:10088 denotes mice
T6714 16638-16643 SO_EXT:0000704 denotes genes
T6713 16555-16562 SO_EXT:0001023 denotes alleles
T6712 16402-16409 SO_EXT:0000704 denotes genetic
T6711 16355-16361 UBERON:0002405 denotes immune
T6710 16283-16292 GO:0000785 denotes chromatin
T6709 16268-16273 CHEBI_SO_EXT:single_stranded_DNA denotes ssDNA
T6708 16093-16100 SO_EXT:0001026 denotes genomic
T6707 16068-16087 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes locus on Chromosome
T6706 16024-16030 UBERON:0002405 denotes immune
T6705 15165-15171 NCBITaxon:39107 denotes murine
T6704 15158-15164 UBERON:0002405 denotes immune
T6703 15140-15146 UBERON:0002405 denotes immune
T6702 15092-15107 SO_EXT:coding_sequence denotes coding sequence
T6701 15087-15091 PR_EXT:000004126 denotes Apcs
T6700 14947-14954 CHEBI_PR_EXT:protein denotes protein
T6699 14932-14939 SO_EXT:sequence_variant_entity denotes variant
T6698 14880-14884 SO_EXT:0000704 denotes gene
T6697 14875-14879 PR_EXT:000004126 denotes Apcs
T6696 14854-14867 SO_EXT:polymorphism denotes polymorphisms
T6695 14838-14853 SO_EXT:coding_sequence denotes coding sequence
T523 44-48 NCBITaxon:10088 denotes Mice
T524 92-96 SO_EXT:0000704 denotes Gene
T525 106-110 NCBITaxon:10088 denotes Mice
T526 202-208 UBERON:0000467 denotes system
T527 213-219 UBERON:0002405 denotes immune
T528 246-253 SO_EXT:0000704 denotes genetic
T529 305-309 SO_EXT:0000704 denotes gene
T530 319-323 NCBITaxon:10088 denotes mice
T531 375-379 SO_EXT:sequence_nullness denotes null
T532 380-385 SO_EXT:0000704 denotes genes
T533 463-467 NCBITaxon:10088 denotes mice
T534 502-506 SO_EXT:0000704 denotes gene
T535 516-520 NCBITaxon:10088 denotes mice
T536 573-580 SO_EXT:0000704 denotes genetic
T537 620-626 UBERON:0002405 denotes immune
T538 647-651 SO_EXT:0000704 denotes gene
T539 661-665 NCBITaxon:10088 denotes mice
T540 706-716 GO:0010467 denotes expression
T541 770-775 SO_EXT:0000704 denotes genes
T542 808-813 NCBITaxon:10088 denotes mouse
T543 829-835 SO_EXT:0001026 denotes genome
T544 931-935 NCBITaxon:10088 denotes mice
T545 1054-1064 _FRAGMENT denotes Chromosome
T546 1067-1074 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes segment
T547 1159-1166 GO:0005634 denotes nuclear
T548 1167-1175 CHEBI_EXT:59132 denotes antigens
T549 1229-1233 SO_EXT:0000704 denotes gene
T550 1326-1331 NCBITaxon:10088 denotes mouse
T551 1356-1360 SO_EXT:0000704 denotes gene
T552 1389-1393 SO_EXT:0000704 denotes gene
T553 1451-1457 UBERON:0002405 denotes immune
T554 1483-1487 SO_EXT:0000704 denotes gene
T2682 1782-1788 UBERON:0002405 denotes immune
T2683 1818-1831 _FRAGMENT denotes production of
T2684 1836-1846 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes antibodies
T2685 1853-1856 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes Abs
T2686 1836-1846 GO:0042571 denotes antibodies
T2687 1853-1856 GO:0042571 denotes Abs
T2688 1890-1898 CHEBI_EXT:59132 denotes antigens
T2689 1912-1923 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T2690 1915-1923 CL_GO_EXT:cell denotes cellular
T2691 1953-1957 CL_GO_EXT:cell denotes cell
T2692 1953-1965 GO:0005634 denotes cell nucleus
T2693 1967-1974 SO_EXT:0000704 denotes Genetic
T2694 2051-2057 NCBITaxon:9606 denotes humans
T2695 2062-2069 NCBITaxon:33208 denotes animals
T2696 2164-2169 SO_EXT:0000704 denotes Genes
T2697 2279-2284 SO_EXT:0000704 denotes genes
T2698 2344-2351 SO_EXT:0000704 denotes genetic
T2699 2416-2422 NCBITaxon:39107 denotes murine
T2700 2491-2496 SO_EXT:0000704 denotes genes
T2701 2497-2507 GO:0065007 denotes modulating
T2702 2512-2525 UBERON:0002405 denotes immune system
T2703 2614-2618 NCBITaxon:10088 denotes mice
T2704 2787-2795 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2705 2803-2815 PR_EXT:000001962 denotes FAS receptor
T2706 2807-2815 GO_EXT:0004872 denotes receptor
T2707 2816-2820 SO_EXT:0000704 denotes gene
T2708 2861-2873 GO:0000806 denotes Y chromosome
T2709 2863-2873 GO_SO_EXT:chromosome denotes chromosome
T2710 2878-2884 UBERON:0002405 denotes immune
T2711 2903-2907 SO_EXT:0000704 denotes gene
T2712 2951-2958 SO_EXT:0000704 denotes genetic
T2713 3161-3168 SO_EXT:0000704 denotes genetic
T2714 3257-3262 SO_EXT:0000704 denotes genes
T2715 3374-3394 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosome locations
T2716 3569-3576 _FRAGMENT denotes loci on
T2717 3584-3594 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes Chromosome
T2718 3631-3636 SO_EXT:0000704 denotes genes
T2719 3799-3804 SO_EXT:0000704 denotes genes
T2720 3883-3891 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2721 3905-3912 SO_EXT:0000704 denotes genetic
T2722 3967-3973 NCBITaxon:39107 denotes murine
T2723 4022-4031 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T2724 4035-4042 CHEBI_PR_EXT:protein denotes protein
T2725 4065-4072 SO_EXT:0000704 denotes genetic
T2726 4097-4102 SO_EXT:0000704 denotes genes
T2727 4103-4111 SO_EXT:sequence_coding_function denotes encoding
T2728 4112-4120 CHEBI_PR_EXT:protein denotes proteins
T2729 4128-4141 UBERON:0002405 denotes immune system
T2730 4193-4199 UBERON:0002405 denotes immune
T2731 4200-4210 GO:0065007 denotes regulation
T2732 4318-4327 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2733 4361-4367 UBERON:0002405 denotes immune
T2734 4453-4457 NCBITaxon:10088 denotes mice
T2735 4492-4496 SO_EXT:0000704 denotes gene
T2736 4506-4510 NCBITaxon:10088 denotes mice
T2737 4729-4736 SO_EXT:0000704 denotes genetic
T2738 4776-4782 UBERON:0002405 denotes immune
T2739 4796-4800 SO_EXT:0000704 denotes gene
T2740 4810-4814 NCBITaxon:10088 denotes mice
T2741 4947-4953 UBERON:0002405 denotes immune
T2742 4982-4986 SO_EXT:0000704 denotes gene
T2743 4996-5000 NCBITaxon:10088 denotes mice
T2744 5077-5082 SO_EXT:0000704 denotes genes
T2745 5117-5121 NCBITaxon:10088 denotes mice
T2746 5159-5166 SO_EXT:sequence_alteration_process denotes mutated
T2747 5167-5173 SO_EXT:0001023 denotes allele
T2748 5204-5210 SO_EXT:0001026 denotes genome
T2749 5272-5276 NCBITaxon:10088 denotes mice
T2750 5301-5309 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2751 5317-5322 UBERON:0001977 denotes serum
T2752 5317-5342 PR_EXT:000004126 denotes serum amyloid P component
T2753 5323-5330 CHEBI:60425 denotes amyloid
T2754 5343-5347 SO_EXT:0000704 denotes gene
T2755 5349-5353 PR_EXT:000004126 denotes Apcs
T2756 5360-5364 PR_EXT:000004126 denotes Apcs
T2757 5375-5379 NCBITaxon:10088 denotes mice
T2758 5381-5385 PR_EXT:000004126 denotes Apcs
T2759 5386-5387 SO_EXT:sequence_nullness_or_absence denotes −
T2760 5388-5389 SO_EXT:sequence_nullness_or_absence denotes −
T2761 5422-5426 SO_EXT:0000704 denotes gene
T2762 5509-5516 SO_EXT:0000704 denotes genetic
T2763 5561-5565 PR_EXT:000004126 denotes Apcs
T2764 5566-5567 SO_EXT:sequence_nullness_or_absence denotes −
T2765 5568-5569 SO_EXT:sequence_nullness_or_absence denotes −
T2766 5570-5574 NCBITaxon:10088 denotes mice
T2767 5612-5619 SO_EXT:sequence_alteration_process denotes mutated
T2768 5620-5624 SO_EXT:0000704 denotes gene
T2769 5688-5692 SO_EXT:0000704 denotes gene
T2770 5726-5730 PR_EXT:000004126 denotes Apcs
T2771 5731-5735 SO_EXT:0000704 denotes gene
T2772 5750-5760 GO_SO_EXT:chromosome denotes Chromosome
T2773 5793-5803 GO_SO_EXT:centromere_or_centromeric_region_or_centromeric_orientation denotes centromere
T2774 6099-6104 SO_EXT:0000704 denotes genes
T2775 6122-6130 SO_EXT:sequence_coding_function denotes encoding
T2776 6131-6137 PR_EXT:000001479 denotes FcγRII
T2777 6143-6162 GO_EXT:0004875 denotes complement receptor
T2778 6163-6166 PR_EXT:000001337 denotes CR1
T2779 6170-6174 PR_EXT:000001337 denotes CD35
T2780 6175-6179 PR_EXT:000001338 denotes CD21
T2781 6216-6220 PR_EXT:000025662 denotes CD55
T2782 6380-6384 SO_EXT:0000704 denotes gene
T2783 6402-6411 UBERON:0000922 denotes embryonic
T2784 6402-6422 CL:0002322 denotes embryonic stem cells
T2785 6417-6422 CL_GO_EXT:cell denotes cells
T2786 6461-6468 SO_EXT:0000704 denotes genetic
T2787 6509-6513 NCBITaxon:10088 denotes mice
T2788 6572-6583 _FRAGMENT denotes interval on
T2789 6591-6601 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes Chromosome
T2790 6610-6621 GO_EXT:biological_movement_or_translocation_process denotes transferred
T2791 6639-6645 SO_EXT:0001026 denotes genome
T2792 6709-6713 SO_EXT:0000704 denotes gene
T2793 6747-6756 UBERON:0000922 denotes embryonic
T2794 6747-6767 CL:0002322 denotes embryonic stem cells
T2795 6762-6767 CL_GO_EXT:cell denotes cells
T2796 6868-6875 SO_EXT:sequence_alteration_process denotes mutated
T2797 6876-6880 PR_EXT:000004126 denotes Apcs
T2798 6881-6885 SO_EXT:0000704 denotes gene
T2799 6954-6959 SO_EXT:0000704 denotes genes
T2800 6981-6988 SO_EXT:0001026 denotes genomes
T2801 7075-7080 SO_EXT:0000704 denotes genes
T2802 7123-7129 UBERON:0002405 denotes immune
T2803 7166-7173 SO_EXT:0000704 denotes genetic
T4424 7255-7259 PR_EXT:000004126 denotes Apcs
T4425 7260-7261 SO_EXT:sequence_nullness_or_absence denotes −
T4426 7262-7263 SO_EXT:sequence_nullness_or_absence denotes −
T4427 7264-7268 NCBITaxon:10088 denotes Mice
T4428 7288-7295 SO_EXT:0000704 denotes genetic
T4429 7367-7371 NCBITaxon:10088 denotes mice
T4430 7425-7432 NCBITaxon:33208 denotes animals
T4431 7449-7457 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T4432 7465-7469 PR_EXT:000004126 denotes Apcs
T4433 7470-7474 SO_EXT:0000704 denotes gene
T4434 7551-7557 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T4435 7558-7562 NCBITaxon:10088 denotes mice
T4436 7666-7672 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T4437 7673-7677 NCBITaxon:10088 denotes mice
T4438 7814-7823 SO_EXT:wild_type_entity_or_quality denotes wild-type
T4439 7842-7846 NCBITaxon:10088 denotes mice
T4440 7899-7902 GO:0042571 denotes Abs
T4441 7977-7990 GO_PATO_EXT:cell_proliferation_or_proliferativity denotes proliferative
T4442 8101-8108 GO:0005634 denotes nuclear
T4443 8109-8112 GO:0042571 denotes Abs
T4444 8129-8138 GO:0000785 denotes chromatin
T4445 8139-8141 GO:0042571 denotes Ab
T4446 8193-8197 PR_EXT:000004126 denotes Apcs
T4447 8198-8199 SO_EXT:sequence_nullness_or_absence denotes −
T4448 8200-8201 SO_EXT:sequence_nullness_or_absence denotes −
T4449 8202-8206 NCBITaxon:10088 denotes mice
T4450 8333-8344 CHMO_UBERON_EXT:bodily_fluid_or_bodily_fluid_experimental_method denotes serological
T4451 8345-8352 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4452 8368-8387 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T4453 8389-8394 CHEBI_SO_EXT:single_stranded_DNA denotes ssDNA
T4454 8405-8424 CHEBI_SO_EXT:double_stranded_DNA denotes double-stranded DNA
T4455 8426-8431 CHEBI_SO_EXT:double_stranded_DNA denotes dsDNA
T4456 8433-8436 GO:0042571 denotes Abs
T4457 8462-8467 UBERON:0002113 denotes renal
T4458 8617-8625 SO:0000357 denotes flanking
T4459 8630-8637 SO_EXT:sequence_alteration_process denotes mutated
T4460 8638-8642 PR_EXT:000004126 denotes Apcs
T4461 8643-8647 SO_EXT:0000704 denotes gene
T4462 8660-8666 UBERON:0002405 denotes immune
T4463 8688-8694 SO_EXT:0001026 denotes genome
T6627 9520-9524 NCBITaxon:10088 denotes Mice
T6628 9549-9563 SO_EXT:microsatellite_unit_or_region denotes microsatellite
T6629 9564-9571 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T6630 9599-9608 GO:0030849 denotes autosomes
T6631 9630-9635 SO_EXT:0000704 denotes genes
T6632 9672-9678 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T6633 9697-9703 SO_EXT:0001026 denotes genome
T6634 9791-9807 SO_EXT:0000018 denotes areas of linkage
T6635 9975-9985 _FRAGMENT denotes Chromosome
T6636 9995-10002 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes segment
T6637 10077-10081 PR_EXT:000004126 denotes Apcs
T6638 10082-10083 SO_EXT:sequence_nullness_or_absence denotes −
T6639 10084-10085 SO_EXT:sequence_nullness_or_absence denotes −
T6640 10086-10090 NCBITaxon:10088 denotes mice
T6641 10131-10142 GO_SO_EXT:chromosome denotes Chromosomes
T8724 19454-19460 SO_EXT:0001026 denotes genome
T8723 19440-19444 NCBITaxon:10088 denotes mice
T8722 19438-19439 SO_EXT:sequence_nullness_or_absence denotes −
T8721 19436-19437 SO_EXT:sequence_nullness_or_absence denotes −
T8720 19431-19435 PR_EXT:000004126 denotes Apcs
T8719 19349-19350 SO_EXT:sequence_nullness_or_absence denotes −
T8718 19347-19348 SO_EXT:sequence_nullness_or_absence denotes −
T8717 19342-19346 PR_EXT:000004126 denotes Apcs
T8716 19283-19287 NCBITaxon:10088 denotes mice
T8715 19281-19282 SO_EXT:sequence_nullness_or_absence denotes −
T8714 19279-19280 SO_EXT:sequence_nullness_or_absence denotes −
T8713 19274-19278 PR_EXT:000004126 denotes Apcs
T8712 19214-19218 NCBITaxon:10088 denotes mice
T8711 19192-19202 GO_SO_EXT:chromosome denotes Chromosome
T8710 19185-19191 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes Female
T17695 36352-36357 UBERON:0001977 denotes serum
T17694 36346-36351 NCBITaxon:10088 denotes mouse
T17693 36344-36345 SO_EXT:sequence_nullness_or_absence denotes −
T17692 36342-36343 SO_EXT:sequence_nullness_or_absence denotes −
T17691 36337-36341 PR_EXT:000004126 denotes Apcs
T17690 36318-36322 PR_EXT:000004126 denotes Apcs
T17689 36282-36287 UBERON:0001977 denotes serum
T17688 36270-36281 GO:0006953 denotes acute-phase
T17687 36077-36080 GO:0042571 denotes Abs
T17686 36072-36076 PR_EXT:000004126 denotes Apcs
T17685 36066-36071 NCBITaxon:10088 denotes mouse
T17684 36054-36060 NCBITaxon:9986 denotes rabbit
T18231 36950-36960 UBERON:0000074 denotes glomerular
T18230 36930-36939 UBERON:0000074 denotes glomeruli
T18229 36900-36915 UBERON:0005749 denotes glomerular tuft
T18228 36829-36838 UBERON:0000074 denotes glomeruli
T18227 36799-36814 UBERON:0005749 denotes glomerular tuft
T18226 36648-36655 CHEBI_EXT:33893 denotes reagent
T18225 36627-36640 CHEBI:29149 denotes periodic acid
T18224 36564-36572 CHEBI:75958 denotes solution
T18223 36526-36532 UBERON:0002113 denotes kidney
T18222 36496-36506 GO_EXT:killing denotes sacrificed
T18221 36452-36456 GO:0016265 denotes died
T18220 36426-36430 NCBITaxon:10088 denotes mice
T18820 38017-38031 CHEBI_EXT:polyacrylamide denotes polyacrylamide
T18819 38013-38016 CHEBI:8984 denotes SDS
T18818 37994-38001 CHEBI:2511 denotes agarose
T18817 37969-37985 CHEBI:4883 denotes ethidium bromide
T18816 37930-37937 SO_EXT:0000112 denotes primers
T18815 37919-37923 NCBITaxon:10088 denotes mice
T18814 37881-37894 SO_EXT:polymorphism denotes polymorphisms
T18813 37850-37857 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T18811 37826-37833 SO_EXT:0000112 denotes primers
T19158 38358-38361 SO_EXT:0000771 denotes QTL
T19157 38289-38292 GO:0042571 denotes Abs
T19156 38225-38229 NCBITaxon:10088 denotes mice
T19155 38093-38096 SO_EXT:0000771 denotes QTL
T19154 38070-38073 SO_EXT:0000771 denotes QTL
R259 T2684 T2683 _lexicallyChainedTo antibodies,production of
R260 T2685 T2683 _lexicallyChainedTo Abs,production of
R261 T2717 T2716 _lexicallyChainedTo Chromosome,loci on
R262 T2789 T2788 _lexicallyChainedTo Chromosome,interval on
R1566 T6636 T6635 _lexicallyChainedTo segment,Chromosome
R1567 T6684 T6683 _lexicallyChainedTo Ab,production of
R2514 T8698 T8697 _lexicallyChainedTo interval,Chromosome
R2515 T8705 T8704 _lexicallyChainedTo interval,Chromosome
R3032 T13402 T13401 _lexicallyChainedTo segment,telomeric Chromosome
R3034 T13306 T13305 _lexicallyChainedTo Chromosome,portion of
R3035 T13404 T13403 _lexicallyChainedTo Chromosome,region of
R3036 T13319 T13318 _lexicallyChainedTo region,Chromosome
R3037 T13408 T13407 _lexicallyChainedTo Chromosome,region on
R3038 T13451 T13450 _lexicallyChainedTo Ab,development of
R3039 T13348 T13347 _lexicallyChainedTo Abs,development of
R3041 T13470 T13469 _lexicallyChainedTo segment,Chromosome
R3043 T13474 T13473 _lexicallyChainedTo Chromosome,interval on
R3047 T13481 T13480 _lexicallyChainedTo Abs,production of
R3065 T13523 T13522 _lexicallyChainedTo antigens,processing of
R5114 T16646 T16645 _lexicallyChainedTo interval,Chromosome
R1 T546 T545 _lexicallyChainedTo segment,Chromosome