PMC:5026484 / 88-1093 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/5026484","sourcedb":"PMC","sourceid":"5026484","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5026484","text":"In their active GTP-bound form, Rab proteins interact with proteins termed effector molecules. In this study, we have thoroughly characterized a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in endosomal trafficking. Within our study, we show that these effectors display a preference for Rab8 family proteins (Rab8, 10, 13 and 15) and that some of the effector domains can bind two Rab proteins via separate binding sites. Structural analysis allowed us to explain the specificity towards Rab8 family members and the presence of two similar Rab binding sites that must have evolved via gene duplication. This study is the first to thoroughly characterize a Rab effector protein that contains two separate Rab binding sites within a single domain, allowing Micals and EHBPs to bind two Rabs simultaneously, thus suggesting previously unknown functions of these effector molecules in endosomal trafficking.\nDOI: http://dx.doi.org/10.7554/eLife.18675.001\n","tracks":[{"project":"Biotea","denotations":[{"id":"T2","span":{"begin":341,"end":345},"obj":"http://purl.obolibrary.org/obo/PR_P55258"},{"id":"T3","span":{"begin":363,"end":367},"obj":"http://purl.obolibrary.org/obo/PR_P55258"},{"id":"T4","span":{"begin":542,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_P55258"},{"id":"T6","span":{"begin":341,"end":345},"obj":"http://purl.obolibrary.org/obo/PR_000013642"},{"id":"T7","span":{"begin":363,"end":367},"obj":"http://purl.obolibrary.org/obo/PR_000013642"},{"id":"T8","span":{"begin":542,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_000013642"},{"id":"T10","span":{"begin":341,"end":345},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52547"},{"id":"T11","span":{"begin":363,"end":367},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52547"},{"id":"T12","span":{"begin":542,"end":546},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52547"},{"id":"T14","span":{"begin":341,"end":345},"obj":"http://purl.obolibrary.org/obo/PR_P35280"},{"id":"T15","span":{"begin":363,"end":367},"obj":"http://purl.obolibrary.org/obo/PR_P35280"},{"id":"T16","span":{"begin":542,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_P35280"},{"id":"T18","span":{"begin":341,"end":345},"obj":"http://purl.obolibrary.org/obo/PR_O24466"},{"id":"T19","span":{"begin":363,"end":367},"obj":"http://purl.obolibrary.org/obo/PR_O24466"},{"id":"T20","span":{"begin":542,"end":546},"obj":"http://purl.obolibrary.org/obo/PR_O24466"},{"id":"T22","span":{"begin":341,"end":345},"obj":"http://purl.bioontology.org/ontology/OMIM/165040"},{"id":"T23","span":{"begin":363,"end":367},"obj":"http://purl.bioontology.org/ontology/OMIM/165040"},{"id":"T24","span":{"begin":542,"end":546},"obj":"http://purl.bioontology.org/ontology/OMIM/165040"},{"id":"T26","span":{"begin":346,"end":352},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79273"},{"id":"T27","span":{"begin":547,"end":553},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79273"},{"id":"T29","span":{"begin":346,"end":352},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45290"},{"id":"T30","span":{"begin":547,"end":553},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45290"},{"id":"T32","span":{"begin":346,"end":352},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/35359004"},{"id":"T33","span":{"begin":547,"end":553},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/35359004"},{"id":"T35","span":{"begin":346,"end":352},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25173"},{"id":"T36","span":{"begin":547,"end":553},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25173"},{"id":"T38","span":{"begin":346,"end":352},"obj":"http://purl.bioontology.org/ontology/MESH/D005190"},{"id":"T39","span":{"begin":547,"end":561},"obj":"http://purl.bioontology.org/ontology/MESH/D005190"},{"id":"T40","span":{"begin":547,"end":553},"obj":"http://purl.bioontology.org/ontology/MESH/D005190"},{"id":"T43","span":{"begin":639,"end":655},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45582"},{"id":"T44","span":{"begin":644,"end":655},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45582"},{"id":"T46","span":{"begin":639,"end":655},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16607"},{"id":"T48","span":{"begin":639,"end":655},"obj":"http://purl.bioontology.org/ontology/MESH/D020440"},{"id":"T50","span":{"begin":639,"end":643},"obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"T52","span":{"begin":639,"end":643},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/67271001"},{"id":"T54","span":{"begin":639,"end":643},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45520"},{"id":"T56","span":{"begin":639,"end":643},"obj":"http://purl.obolibrary.org/obo/SO_0000704"},{"id":"T58","span":{"begin":639,"end":643},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612"},{"id":"T60","span":{"begin":644,"end":655},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/89049001"},{"id":"T61","span":{"begin":9,"end":15},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118408"},{"id":"T62","span":{"begin":9,"end":15},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C154405"},{"id":"T63","span":{"begin":9,"end":15},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45329"},{"id":"T64","span":{"begin":9,"end":15},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70747"},{"id":"T65","span":{"begin":9,"end":15},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49649"},{"id":"T66","span":{"begin":9,"end":15},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/55561003"},{"id":"T67","span":{"begin":16,"end":19},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000170846"},{"id":"T68","span":{"begin":16,"end":19},"obj":"http://purl.bioontology.org/ontology/MESH/D006160"},{"id":"T69","span":{"begin":16,"end":19},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C536"},{"id":"T70","span":{"begin":16,"end":19},"obj":"http://purl.obolibrary.org/obo/CHEBI_15996"},{"id":"T71","span":{"begin":16,"end":19},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/91262008"},{"id":"T72","span":{"begin":20,"end":25},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82888"},{"id":"T73","span":{"begin":426,"end":430},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82888"},{"id":"T74","span":{"begin":461,"end":468},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82888"},{"id":"T75","span":{"begin":598,"end":605},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82888"},{"id":"T76","span":{"begin":762,"end":769},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82888"},{"id":"T77","span":{"begin":829,"end":833},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82888"},{"id":"T78","span":{"begin":20,"end":25},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70987"},{"id":"T79","span":{"begin":20,"end":25},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80696"},{"id":"T80","span":{"begin":26,"end":30},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25513"},{"id":"T81","span":{"begin":26,"end":30},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19464"},{"id":"T82","span":{"begin":26,"end":30},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/246176004"},{"id":"T83","span":{"begin":32,"end":35},"obj":"http://purl.obolibrary.org/obo/PR_P17610"},{"id":"T84","span":{"begin":145,"end":148},"obj":"http://purl.obolibrary.org/obo/PR_P17610"},{"id":"T85","span":{"begin":435,"end":438},"obj":"http://purl.obolibrary.org/obo/PR_P17610"},{"id":"T86","span":{"begin":594,"end":597},"obj":"http://purl.obolibrary.org/obo/PR_P17610"},{"id":"T87","span":{"begin":710,"end":713},"obj":"http://purl.obolibrary.org/obo/PR_P17610"},{"id":"T88","span":{"begin":758,"end":761},"obj":"http://purl.obolibrary.org/obo/PR_P17610"},{"id":"T89","span":{"begin":32,"end":35},"obj":"http://purl.obolibrary.org/obo/PR_000003829"},{"id":"T90","span":{"begin":145,"end":148},"obj":"http://purl.obolibrary.org/obo/PR_000003829"},{"id":"T91","span":{"begin":435,"end":438},"obj":"http://purl.obolibrary.org/obo/PR_000003829"},{"id":"T92","span":{"begin":594,"end":597},"obj":"http://purl.obolibrary.org/obo/PR_000003829"},{"id":"T93","span":{"begin":710,"end":713},"obj":"http://purl.obolibrary.org/obo/PR_000003829"},{"id":"T94","span":{"begin":758,"end":761},"obj":"http://purl.obolibrary.org/obo/PR_000003829"},{"id":"T95","span":{"begin":32,"end":35},"obj":"http://purl.bioontology.org/ontology/OMIM/600862"},{"id":"T96","span":{"begin":145,"end":148},"obj":"http://purl.bioontology.org/ontology/OMIM/600862"},{"id":"T97","span":{"begin":435,"end":438},"obj":"http://purl.bioontology.org/ontology/OMIM/600862"},{"id":"T98","span":{"begin":594,"end":597},"obj":"http://purl.bioontology.org/ontology/OMIM/600862"},{"id":"T99","span":{"begin":710,"end":713},"obj":"http://purl.bioontology.org/ontology/OMIM/600862"},{"id":"T100","span":{"begin":758,"end":761},"obj":"http://purl.bioontology.org/ontology/OMIM/600862"},{"id":"T101","span":{"begin":36,"end":44},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000005817"},{"id":"T102","span":{"begin":59,"end":67},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000005817"},{"id":"T103","span":{"begin":184,"end":192},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000005817"},{"id":"T104","span":{"begin":353,"end":361},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000005817"},{"id":"T105","span":{"begin":439,"end":447},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000005817"},{"id":"T106","span":{"begin":36,"end":44},"obj":"http://purl.bioontology.org/ontology/MESH/D011506"},{"id":"T107","span":{"begin":59,"end":67},"obj":"http://purl.bioontology.org/ontology/MESH/D011506"},{"id":"T108","span":{"begin":184,"end":192},"obj":"http://purl.bioontology.org/ontology/MESH/D011506"},{"id":"T109","span":{"begin":353,"end":361},"obj":"http://purl.bioontology.org/ontology/MESH/D011506"},{"id":"T110","span":{"begin":439,"end":447},"obj":"http://purl.bioontology.org/ontology/MESH/D011506"},{"id":"T111","span":{"begin":36,"end":44},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0033684"},{"id":"T112","span":{"begin":59,"end":67},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0033684"},{"id":"T113","span":{"begin":184,"end":192},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0033684"},{"id":"T114","span":{"begin":353,"end":361},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0033684"},{"id":"T115","span":{"begin":439,"end":447},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0033684"},{"id":"T116","span":{"begin":36,"end":44},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T117","span":{"begin":59,"end":67},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T118","span":{"begin":184,"end":192},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T119","span":{"begin":353,"end":361},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T120","span":{"begin":439,"end":447},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T121","span":{"begin":723,"end":730},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T122","span":{"begin":75,"end":83},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/734539000"},{"id":"T123","span":{"begin":149,"end":157},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/734539000"},{"id":"T124","span":{"begin":405,"end":413},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/734539000"},{"id":"T125","span":{"begin":714,"end":722},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/734539000"},{"id":"T126","span":{"begin":913,"end":921},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/734539000"},{"id":"T127","span":{"begin":103,"end":108},"obj":"http://purl.obolibrary.org/obo/OBI_0000073"},{"id":"T128","span":{"begin":280,"end":285},"obj":"http://purl.obolibrary.org/obo/OBI_0000073"},{"id":"T129","span":{"begin":662,"end":667},"obj":"http://purl.obolibrary.org/obo/OBI_0000073"},{"id":"T130","span":{"begin":103,"end":108},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/224699009"},{"id":"T131","span":{"begin":280,"end":285},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/224699009"},{"id":"T132","span":{"begin":662,"end":667},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/224699009"},{"id":"T133","span":{"begin":103,"end":108},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45319"},{"id":"T134","span":{"begin":280,"end":285},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45319"},{"id":"T135","span":{"begin":662,"end":667},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45319"},{"id":"T136","span":{"begin":103,"end":108},"obj":"http://purl.obolibrary.org/obo/OBI_0000066"},{"id":"T137","span":{"begin":280,"end":285},"obj":"http://purl.obolibrary.org/obo/OBI_0000066"},{"id":"T138","span":{"begin":662,"end":667},"obj":"http://purl.obolibrary.org/obo/OBI_0000066"},{"id":"T139","span":{"begin":103,"end":108},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63537"},{"id":"T140","span":{"begin":280,"end":285},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63537"},{"id":"T141","span":{"begin":662,"end":667},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63537"},{"id":"T142","span":{"begin":103,"end":108},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15206"},{"id":"T143","span":{"begin":280,"end":285},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15206"},{"id":"T144","span":{"begin":662,"end":667},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15206"},{"id":"T145","span":{"begin":103,"end":108},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63536"},{"id":"T146","span":{"begin":280,"end":285},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63536"},{"id":"T147","span":{"begin":662,"end":667},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63536"},{"id":"T148","span":{"begin":129,"end":142},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62606"},{"id":"T149","span":{"begin":158,"end":164},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13379"},{"id":"T150","span":{"begin":792,"end":798},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13379"},{"id":"T151","span":{"begin":158,"end":164},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49556"},{"id":"T152","span":{"begin":792,"end":798},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49556"},{"id":"T153","span":{"begin":158,"end":164},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62706"},{"id":"T154","span":{"begin":792,"end":798},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62706"},{"id":"T155","span":{"begin":158,"end":164},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62289"},{"id":"T156","span":{"begin":792,"end":798},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62289"},{"id":"T157","span":{"begin":158,"end":164},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/609431004"},{"id":"T158","span":{"begin":792,"end":798},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/609431004"},{"id":"T159","span":{"begin":158,"end":164},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66734"},{"id":"T160","span":{"begin":792,"end":798},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66734"},{"id":"T161","span":{"begin":200,"end":205},"obj":"http://purl.obolibrary.org/obo/PR_000010399"},{"id":"T162","span":{"begin":200,"end":205},"obj":"http://purl.obolibrary.org/obo/PR_Q8VDP3"},{"id":"T163","span":{"begin":316,"end":323},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49927"},{"id":"T164","span":{"begin":316,"end":323},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25485"},{"id":"T165","span":{"begin":326,"end":336},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41187"},{"id":"T166","span":{"begin":452,"end":460},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/263869007"},{"id":"T167","span":{"begin":749,"end":757},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/263869007"},{"id":"T168","span":{"begin":452,"end":460},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63803"},{"id":"T169","span":{"begin":749,"end":757},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63803"},{"id":"T170","span":{"begin":461,"end":474},"obj":"http://purl.bioontology.org/ontology/MESH/D001665"},{"id":"T171","span":{"begin":598,"end":611},"obj":"http://purl.bioontology.org/ontology/MESH/D001665"},{"id":"T172","span":{"begin":762,"end":775},"obj":"http://purl.bioontology.org/ontology/MESH/D001665"},{"id":"T173","span":{"begin":461,"end":468},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T174","span":{"begin":598,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T175","span":{"begin":762,"end":769},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T176","span":{"begin":461,"end":468},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/257768005"},{"id":"T177","span":{"begin":598,"end":605},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/257768005"},{"id":"T178","span":{"begin":762,"end":769},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/257768005"},{"id":"T179","span":{"begin":461,"end":468},"obj":"http://purl.obolibrary.org/obo/OBI_0001588"},{"id":"T180","span":{"begin":598,"end":605},"obj":"http://purl.obolibrary.org/obo/OBI_0001588"},{"id":"T181","span":{"begin":762,"end":769},"obj":"http://purl.obolibrary.org/obo/OBI_0001588"},{"id":"T182","span":{"begin":461,"end":468},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18219"},{"id":"T183","span":{"begin":598,"end":605},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18219"},{"id":"T184","span":{"begin":762,"end":769},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18219"},{"id":"T185","span":{"begin":469,"end":474},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37901"},{"id":"T186","span":{"begin":606,"end":611},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37901"},{"id":"T187","span":{"begin":770,"end":775},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C37901"},{"id":"T188","span":{"begin":476,"end":495},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/27482005"},{"id":"T189","span":{"begin":476,"end":486},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41186"},{"id":"T190","span":{"begin":487,"end":495},"obj":"http://purl.bioontology.org/ontology/MESH/Q000032"},{"id":"T191","span":{"begin":487,"end":495},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/272389005"},{"id":"T192","span":{"begin":487,"end":495},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25391"},{"id":"T193","span":{"begin":522,"end":533},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C134032"},{"id":"T194","span":{"begin":522,"end":533},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41395"},{"id":"T195","span":{"begin":522,"end":533},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41388"},{"id":"T196","span":{"begin":570,"end":581},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/52101004"},{"id":"T197","span":{"begin":570,"end":578},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/386397008"},{"id":"T198","span":{"begin":570,"end":578},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25626"},{"id":"T199","span":{"begin":570,"end":578},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/705057003"},{"id":"T200","span":{"begin":723,"end":730},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64858"},{"id":"T201","span":{"begin":723,"end":730},"obj":"http://purl.obolibrary.org/obo/GO_0003675"},{"id":"T202","span":{"begin":723,"end":730},"obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"T203","span":{"begin":723,"end":730},"obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"T204","span":{"begin":723,"end":730},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000148318"},{"id":"T205","span":{"begin":723,"end":730},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T206","span":{"begin":723,"end":730},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T207","span":{"begin":723,"end":730},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41172"},{"id":"T208","span":{"begin":723,"end":730},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/88878007"},{"id":"T209","span":{"begin":723,"end":730},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10036987"},{"id":"T210","span":{"begin":785,"end":791},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48440"},{"id":"T211","span":{"begin":785,"end":791},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150721"},{"id":"T212","span":{"begin":785,"end":791},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/125681006"},{"id":"T213","span":{"begin":886,"end":893},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/261665006"},{"id":"T214","span":{"begin":886,"end":893},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38311"},{"id":"T215","span":{"begin":886,"end":893},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150001"},{"id":"T216","span":{"begin":886,"end":893},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150002"},{"id":"T217","span":{"begin":886,"end":893},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C150003"},{"id":"T218","span":{"begin":886,"end":893},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123772"},{"id":"T219","span":{"begin":886,"end":893},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998"},{"id":"T220","span":{"begin":894,"end":903},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142468"},{"id":"T221","span":{"begin":958,"end":961},"obj":"http://purl.obolibrary.org/obo/OBI_0002110"},{"id":"T222","span":{"begin":973,"end":976},"obj":"http://purl.obolibrary.org/obo/OBI_0002110"},{"id":"T223","span":{"begin":958,"end":961},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C153902"},{"id":"T224","span":{"begin":973,"end":976},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C153902"},{"id":"T225","span":{"begin":958,"end":961},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71462"},{"id":"T226","span":{"begin":973,"end":976},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71462"},{"id":"T227","span":{"begin":963,"end":967},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142279"},{"id":"T228","span":{"begin":977,"end":980},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19711"},{"id":"T229","span":{"begin":977,"end":980},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19223"}],"namespaces":[{"prefix":"omim","uri":"http://purl.bioontology.org/ontology/OMIM/"},{"prefix":"pr","uri":"http://purl.obolibrary.org/obo/PR_"}],"attributes":[{"subj":"T2","pred":"source","obj":"Biotea"},{"subj":"T3","pred":"source","obj":"Biotea"},{"subj":"T4","pred":"source","obj":"Biotea"},{"subj":"T6","pred":"source","obj":"Biotea"},{"subj":"T7","pred":"source","obj":"Biotea"},{"subj":"T8","pred":"source","obj":"Biotea"},{"subj":"T10","pred":"source","obj":"Biotea"},{"subj":"T11","pred":"source","obj":"Biotea"},{"subj":"T12","pred":"source","obj":"Biotea"},{"subj":"T14","pred":"source","obj":"Biotea"},{"subj":"T15","pred":"source","obj":"Biotea"},{"subj":"T16","pred":"source","obj":"Biotea"},{"subj":"T18","pred":"source","obj":"Biotea"},{"subj":"T19","pred":"source","obj":"Biotea"},{"subj":"T20","pred":"source","obj":"Biotea"},{"subj":"T22","pred":"source","obj":"Biotea"},{"subj":"T23","pred":"source","obj":"Biotea"},{"subj":"T24","pred":"source","obj":"Biotea"},{"subj":"T26","pred":"source","obj":"Biotea"},{"subj":"T27","pred":"source","obj":"Biotea"},{"subj":"T29","pred":"source","obj":"Biotea"},{"subj":"T30","pred":"source","obj":"Biotea"},{"subj":"T32","pred":"source","obj":"Biotea"},{"subj":"T33","pred":"source","obj":"Biotea"},{"subj":"T35","pred":"source","obj":"Biotea"},{"subj":"T36","pred":"source","obj":"Biotea"},{"subj":"T38","pred":"source","obj":"Biotea"},{"subj":"T39","pred":"source","obj":"Biotea"},{"subj":"T40","pred":"source","obj":"Biotea"},{"subj":"T43","pred":"source","obj":"Biotea"},{"subj":"T44","pred":"source","obj":"Biotea"},{"subj":"T46","pred":"source","obj":"Biotea"},{"subj":"T48","pred":"source","obj":"Biotea"},{"subj":"T50","pred":"source","obj":"Biotea"},{"subj":"T52","pred":"source","obj":"Biotea"},{"subj":"T54","pred":"source","obj":"Biotea"},{"subj":"T56","pred":"source","obj":"Biotea"},{"subj":"T58","pred":"source","obj":"Biotea"},{"subj":"T60","pred":"source","obj":"Biotea"},{"subj":"T61","pred":"source","obj":"Biotea"},{"subj":"T62","pred":"source","obj":"Biotea"},{"subj":"T63","pred":"source","obj":"Biotea"},{"subj":"T64","pred":"source","obj":"Biotea"},{"subj":"T65","pred":"source","obj":"Biotea"},{"subj":"T66","pred":"source","obj":"Biotea"},{"subj":"T67","pred":"source","obj":"Biotea"},{"subj":"T68","pred":"source","obj":"Biotea"},{"subj":"T69","pred":"source","obj":"Biotea"},{"subj":"T70","pred":"source","obj":"Biotea"},{"subj":"T71","pred":"source","obj":"Biotea"},{"subj":"T72","pred":"source","obj":"Biotea"},{"subj":"T73","pred":"source","obj":"Biotea"},{"subj":"T74","pred":"source","obj":"Biotea"},{"subj":"T75","pred":"source","obj":"Biotea"},{"subj":"T76","pred":"source","obj":"Biotea"},{"subj":"T77","pred":"source","obj":"Biotea"},{"subj":"T78","pred":"source","obj":"Biotea"},{"subj":"T79","pred":"source","obj":"Biotea"},{"subj":"T80","pred":"source","obj":"Biotea"},{"subj":"T81","pred":"source","obj":"Biotea"},{"subj":"T82","pred":"source","obj":"Biotea"},{"subj":"T83","pred":"source","obj":"Biotea"},{"subj":"T84","pred":"source","obj":"Biotea"},{"subj":"T85","pred":"source","obj":"Biotea"},{"subj":"T86","pred":"source","obj":"Biotea"},{"subj":"T87","pred":"source","obj":"Biotea"},{"subj":"T88","pred":"source","obj":"Biotea"},{"subj":"T89","pred":"source","obj":"Biotea"},{"subj":"T90","pred":"source","obj":"Biotea"},{"subj":"T91","pred":"source","obj":"Biotea"},{"subj":"T92","pred":"source","obj":"Biotea"},{"subj":"T93","pred":"source","obj":"Biotea"},{"subj":"T94","pred":"source","obj":"Biotea"},{"subj":"T95","pred":"source","obj":"Biotea"},{"subj":"T96","pred":"source","obj":"Biotea"},{"subj":"T97","pred":"source","obj":"Biotea"},{"subj":"T98","pred":"source","obj":"Biotea"},{"subj":"T99","pred":"source","obj":"Biotea"},{"subj":"T100","pred":"source","obj":"Biotea"},{"subj":"T101","pred":"source","obj":"Biotea"},{"subj":"T102","pred":"source","obj":"Biotea"},{"subj":"T103","pred":"source","obj":"Biotea"},{"subj":"T104","pred":"source","obj":"Biotea"},{"subj":"T105","pred":"source","obj":"Biotea"},{"subj":"T106","pred":"source","obj":"Biotea"},{"subj":"T107","pred":"source","obj":"Biotea"},{"subj":"T108","pred":"source","obj":"Biotea"},{"subj":"T109","pred":"source","obj":"Biotea"},{"subj":"T110","pred":"source","obj":"Biotea"},{"subj":"T111","pred":"source","obj":"Biotea"},{"subj":"T112","pred":"source","obj":"Biotea"},{"subj":"T113","pred":"source","obj":"Biotea"},{"subj":"T114","pred":"source","obj":"Biotea"},{"subj":"T115","pred":"source","obj":"Biotea"},{"subj":"T116","pred":"source","obj":"Biotea"},{"subj":"T117","pred":"source","obj":"Biotea"},{"subj":"T118","pred":"source","obj":"Biotea"},{"subj":"T119","pred":"source","obj":"Biotea"},{"subj":"T120","pred":"source","obj":"Biotea"},{"subj":"T121","pred":"source","obj":"Biotea"},{"subj":"T122","pred":"source","obj":"Biotea"},{"subj":"T123","pred":"source","obj":"Biotea"},{"subj":"T124","pred":"source","obj":"Biotea"},{"subj":"T125","pred":"source","obj":"Biotea"},{"subj":"T126","pred":"source","obj":"Biotea"},{"subj":"T127","pred":"source","obj":"Biotea"},{"subj":"T128","pred":"source","obj":"Biotea"},{"subj":"T129","pred":"source","obj":"Biotea"},{"subj":"T130","pred":"source","obj":"Biotea"},{"subj":"T131","pred":"source","obj":"Biotea"},{"subj":"T132","pred":"source","obj":"Biotea"},{"subj":"T133","pred":"source","obj":"Biotea"},{"subj":"T134","pred":"source","obj":"Biotea"},{"subj":"T135","pred":"source","obj":"Biotea"},{"subj":"T136","pred":"source","obj":"Biotea"},{"subj":"T137","pred":"source","obj":"Biotea"},{"subj":"T138","pred":"source","obj":"Biotea"},{"subj":"T139","pred":"source","obj":"Biotea"},{"subj":"T140","pred":"source","obj":"Biotea"},{"subj":"T141","pred":"source","obj":"Biotea"},{"subj":"T142","pred":"source","obj":"Biotea"},{"subj":"T143","pred":"source","obj":"Biotea"},{"subj":"T144","pred":"source","obj":"Biotea"},{"subj":"T145","pred":"source","obj":"Biotea"},{"subj":"T146","pred":"source","obj":"Biotea"},{"subj":"T147","pred":"source","obj":"Biotea"},{"subj":"T148","pred":"source","obj":"Biotea"},{"subj":"T149","pred":"source","obj":"Biotea"},{"subj":"T150","pred":"source","obj":"Biotea"},{"subj":"T151","pred":"source","obj":"Biotea"},{"subj":"T152","pred":"source","obj":"Biotea"},{"subj":"T153","pred":"source","obj":"Biotea"},{"subj":"T154","pred":"source","obj":"Biotea"},{"subj":"T155","pred":"source","obj":"Biotea"},{"subj":"T156","pred":"source","obj":"Biotea"},{"subj":"T157","pred":"source","obj":"Biotea"},{"subj":"T158","pred":"source","obj":"Biotea"},{"subj":"T159","pred":"source","obj":"Biotea"},{"subj":"T160","pred":"source","obj":"Biotea"},{"subj":"T161","pred":"source","obj":"Biotea"},{"subj":"T162","pred":"source","obj":"Biotea"},{"subj":"T163","pred":"source","obj":"Biotea"},{"subj":"T164","pred":"source","obj":"Biotea"},{"subj":"T165","pred":"source","obj":"Biotea"},{"subj":"T166","pred":"source","obj":"Biotea"},{"subj":"T167","pred":"source","obj":"Biotea"},{"subj":"T168","pred":"source","obj":"Biotea"},{"subj":"T169","pred":"source","obj":"Biotea"},{"subj":"T170","pred":"source","obj":"Biotea"},{"subj":"T171","pred":"source","obj":"Biotea"},{"subj":"T172","pred":"source","obj":"Biotea"},{"subj":"T173","pred":"source","obj":"Biotea"},{"subj":"T174","pred":"source","obj":"Biotea"},{"subj":"T175","pred":"source","obj":"Biotea"},{"subj":"T176","pred":"source","obj":"Biotea"},{"subj":"T177","pred":"source","obj":"Biotea"},{"subj":"T178","pred":"source","obj":"Biotea"},{"subj":"T179","pred":"source","obj":"Biotea"},{"subj":"T180","pred":"source","obj":"Biotea"},{"subj":"T181","pred":"source","obj":"Biotea"},{"subj":"T182","pred":"source","obj":"Biotea"},{"subj":"T183","pred":"source","obj":"Biotea"},{"subj":"T184","pred":"source","obj":"Biotea"},{"subj":"T185","pred":"source","obj":"Biotea"},{"subj":"T186","pred":"source","obj":"Biotea"},{"subj":"T187","pred":"source","obj":"Biotea"},{"subj":"T188","pred":"source","obj":"Biotea"},{"subj":"T189","pred":"source","obj":"Biotea"},{"subj":"T190","pred":"source","obj":"Biotea"},{"subj":"T191","pred":"source","obj":"Biotea"},{"subj":"T192","pred":"source","obj":"Biotea"},{"subj":"T193","pred":"source","obj":"Biotea"},{"subj":"T194","pred":"source","obj":"Biotea"},{"subj":"T195","pred":"source","obj":"Biotea"},{"subj":"T196","pred":"source","obj":"Biotea"},{"subj":"T197","pred":"source","obj":"Biotea"},{"subj":"T198","pred":"source","obj":"Biotea"},{"subj":"T199","pred":"source","obj":"Biotea"},{"subj":"T200","pred":"source","obj":"Biotea"},{"subj":"T201","pred":"source","obj":"Biotea"},{"subj":"T202","pred":"source","obj":"Biotea"},{"subj":"T203","pred":"source","obj":"Biotea"},{"subj":"T204","pred":"source","obj":"Biotea"},{"subj":"T205","pred":"source","obj":"Biotea"},{"subj":"T206","pred":"source","obj":"Biotea"},{"subj":"T207","pred":"source","obj":"Biotea"},{"subj":"T208","pred":"source","obj":"Biotea"},{"subj":"T209","pred":"source","obj":"Biotea"},{"subj":"T210","pred":"source","obj":"Biotea"},{"subj":"T211","pred":"source","obj":"Biotea"},{"subj":"T212","pred":"source","obj":"Biotea"},{"subj":"T213","pred":"source","obj":"Biotea"},{"subj":"T214","pred":"source","obj":"Biotea"},{"subj":"T215","pred":"source","obj":"Biotea"},{"subj":"T216","pred":"source","obj":"Biotea"},{"subj":"T217","pred":"source","obj":"Biotea"},{"subj":"T218","pred":"source","obj":"Biotea"},{"subj":"T219","pred":"source","obj":"Biotea"},{"subj":"T220","pred":"source","obj":"Biotea"},{"subj":"T221","pred":"source","obj":"Biotea"},{"subj":"T222","pred":"source","obj":"Biotea"},{"subj":"T223","pred":"source","obj":"Biotea"},{"subj":"T224","pred":"source","obj":"Biotea"},{"subj":"T225","pred":"source","obj":"Biotea"},{"subj":"T226","pred":"source","obj":"Biotea"},{"subj":"T227","pred":"source","obj":"Biotea"},{"subj":"T228","pred":"source","obj":"Biotea"},{"subj":"T229","pred":"source","obj":"Biotea"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Biotea","color":"#b4ec93","default":true}]}]}}